Apoc3

Summary

Gene Symbol: Apoc3
Description: apolipoprotein C3
Alias: ApoC-III, apo-CIII, apolipoprotein C-III, apolipoprotein C-3
Species: rat

Top Publications

  1. ncbi Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver
    E Windler
    J Lipid Res 26:556-65. 1985
  2. ncbi Alterations in rat serum lipids and apolipoproteins following clofibrate treatment
    N Dashti
    Atherosclerosis 49:255-66. 1983
  3. ncbi Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney and pancreas transplantation
    T A Hughes
    Department of Medicine, University of Tennessee, Memphis 38163
    Metabolism 43:333-47. 1994
  4. ncbi Association between the SstI polymorphism of the apolipoprotein C-III gene, glucose intolerance and cardiovascular risk in renal transplant recipients
    E Rodrigo
    Department of Nephrology, Hospital Valdecilla, Santander, Spain
    Transplant Proc 34:379. 2002
  5. ncbi Increased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population
    Hermes Florez
    University of Miami Miller School of Medicine, Miami, FL, USA
    Atherosclerosis 188:134-41. 2006
  6. pmc Amyloid triangles, squares, and loops of apolipoprotein C-III
    Michel de Messieres
    Laboratory of Molecular Biophysics and Protein Expression Facility, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, and Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States
    Biochemistry 53:3261-3. 2014
  7. doi Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma
    Toshihiro Inoue
    Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Invest Ophthalmol Vis Sci 54:5353-8. 2013
  8. doi Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans
    Mark J Graham
    Isis Pharmaceuticals, Carlsbad, CA 92010, USA
    Circ Res 112:1479-90. 2013
  9. ncbi Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome
    L Sedova
    Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Int J Obes Relat Metab Disord 28:719-25. 2004
  10. ncbi Effect of bile duct obstruction on the expression of intestinal mRNA related to cholesterol and bile acid metabolism in the rat
    Toshinori Kamisako
    Department of Hygiene, Kinki University School of Medicine, Osakasayama, Japan
    J Gastroenterol Hepatol 22:125-31. 2007

Research Grants

  1. MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMES
    Michael Miller; Fiscal Year: 2003
  2. NUTRITION ACADEMIC AWARD
    Michael Miller; Fiscal Year: 2004

Scientific Experts

  • Toshinori Kamisako
  • M J Graham
  • Naoki Ohtsu
  • G M Dallinga-Thie
  • Philip E Morgan
  • Petar Alaupovic
  • J Dallongeville
  • Yoshiji Yamada
  • John E Hokanson
  • Richard L Klein
  • Hermes Florez
  • M Miller
  • M C Jong
  • Michel de Messieres
  • Toshihiro Inoue
  • Jiaxiang Wang
  • Veronica Ceccarelli
  • Sandrine Caron
  • Per Ola Attman
  • Rebecka Holmberg
  • Aso Saeed
  • Elzbieta Nowakowska Fortuna
  • Diana M Lee
  • Esther M M Ooi
  • Jihoe Kim
  • Caren E Smith
  • Puneetpal Singh
  • M C Y Ng
  • He Kun Liu
  • Ilse Duivenvoorden
  • Louis M Havekes
  • Gery Gerritsen
  • Keiko Shimokata
  • L Sedova
  • J C Fruchart
  • Rick K Huang
  • Jennifer C Lee
  • Yi He
  • E Rodrigo
  • Takahiro Kawaji
  • Hidenobu Tanihara
  • Fuquan Yang
  • Da Zhang
  • Zhankui Jia
  • Lei Wang
  • Shu Zheng
  • Yuxia Fan
  • Pan Qin
  • Jiekai Yu
  • Bart Staels
  • Gunilla Olivecrona
  • Rita Roberti
  • Sven Francque
  • Ola Samuelsson
  • Folkert Kuipers
  • Luc Van Gaal
  • Anne Muhr-Tailleux
  • Joshua Wages
  • Nicholas Knowlton
  • Carolina Huaman Samanez
  • Hans Herlitz
  • Joel T Haas
  • Essam Refai
  • Emira Ayroldi
  • Doris T Chan
  • An Verrijken
  • Anders Höög
  • Giuseppe Nocentini
  • Alba Vecchini
  • Sudha B Biddinger
  • Gisele Mautino
  • Daniel Duran-Sandoval
  • Luciano Binaglia
  • Michael Centola
  • Ilse Mertens
  • P Hugh R Barrett
  • Dick C Chan
  • Carlo Riccardi
  • Paolo Di Nardo
  • Gregor Guron
  • Ashley B Irish
  • Lisa Juntti-Berggren
  • Gerald F Watts
  • Janne Prawitt
  • Theodore W K Ng
  • Marja Riitta Taskinen
  • Rosanne M Crooke
  • Gert Jensen
  • Kenneth W Jackson
  • Gursharan K Dogra

Detail Information

Publications52

  1. ncbi Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver
    E Windler
    J Lipid Res 26:556-65. 1985
    ..Preferential loss of apolipoprotein C-II during remnant formation may regulate the termination of triglyceride hydrolysis prior to complete removal of triglycerides from chylomicrons and VLDL...
  2. ncbi Alterations in rat serum lipids and apolipoproteins following clofibrate treatment
    N Dashti
    Atherosclerosis 49:255-66. 1983
    ..These observations suggest that the hypolipidemic effect of clofibrate in the normolipemic rat is caused mainly by diminished hepatic secretion, rather than by enhanced catabolism, of triglyceride-rich lipoproteins...
  3. ncbi Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney and pancreas transplantation
    T A Hughes
    Department of Medicine, University of Tennessee, Memphis 38163
    Metabolism 43:333-47. 1994
    ..The addition of a pancreas to a kidney transplant had no obvious impact on the lipoproteins.(ABSTRACT TRUNCATED AT 400 WORDS)..
  4. ncbi Association between the SstI polymorphism of the apolipoprotein C-III gene, glucose intolerance and cardiovascular risk in renal transplant recipients
    E Rodrigo
    Department of Nephrology, Hospital Valdecilla, Santander, Spain
    Transplant Proc 34:379. 2002
  5. ncbi Increased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population
    Hermes Florez
    University of Miami Miller School of Medicine, Miami, FL, USA
    Atherosclerosis 188:134-41. 2006
    ..52, P < 0.01). These results suggest that higher apo C-III may contribute to the increased cardiovascular risk in subjects with insulin resistance and type 2 diabetes through its effects on triglycerides and LDL particle size...
  6. pmc Amyloid triangles, squares, and loops of apolipoprotein C-III
    Michel de Messieres
    Laboratory of Molecular Biophysics and Protein Expression Facility, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, and Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States
    Biochemistry 53:3261-3. 2014
    ..Triangles and squares with a width of ~50 nm were also observed, which may be a novel form of amyloid or related to previously reported amyloid rings...
  7. doi Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma
    Toshihiro Inoue
    Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Invest Ophthalmol Vis Sci 54:5353-8. 2013
    ..To investigate levels of biomarkers of Alzheimer's disease in the aqueous humor in patients with open-angle glaucoma (OAG)...
  8. doi Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans
    Mark J Graham
    Isis Pharmaceuticals, Carlsbad, CA 92010, USA
    Circ Res 112:1479-90. 2013
    ..Furthermore, elevated apoC-III levels have been associated with metabolic syndrome and type 2 diabetes mellitus. To date, no selective apoC-III therapeutic agent has been evaluated in the clinic...
  9. ncbi Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome
    L Sedova
    Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Int J Obes Relat Metab Disord 28:719-25. 2004
    ....
  10. ncbi Effect of bile duct obstruction on the expression of intestinal mRNA related to cholesterol and bile acid metabolism in the rat
    Toshinori Kamisako
    Department of Hygiene, Kinki University School of Medicine, Osakasayama, Japan
    J Gastroenterol Hepatol 22:125-31. 2007
    ..The purpose of this study was to evaluate the effect of bile duct ligation (BDL) on the expression of intestinal and hepatic genes that are important for cholesterol and bile acid metabolism...
  11. ncbi Effects of apolipoproteins C on oxidative phosphorylation in rat liver mitochondria
    L E Panin
    Institute of Biochemistry, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk
    Bull Exp Biol Med 130:769-71. 2000
    ..ApoC-III completely blocked oxidative phosphorylation during oxidation of palmitoyl carnitine by mitochondria, while the respiration rate in metabolic state 4 remained unchanged...
  12. ncbi 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase
    K Schoonjans
    LBRE, U 325 INSERM, Institut Pasteur de Lille, France
    FEBS Lett 452:160-4. 1999
    ..These results suggest that the triglyceride-lowering effect of statins involves a stimulation of lipoprotein lipase-mediated clearance of triglyceride-rich lipoproteins...
  13. pmc Apolipoprotein C3 polymorphisms, cognitive function and diabetes in Caribbean origin Hispanics
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5465. 2009
    Apolipoprotein C3 (APOC3) modulates triglyceride metabolism through inhibition of lipoprotein lipase, but is itself regulated by insulin, so that APOC3 represents a potential mechanism by which glucose metabolism may affect lipid ..
  14. pmc Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes
    G M Dallinga-Thie
    Department of Medicine and Endocrinology, University Hospital, Utrecht, The Netherlands
    J Clin Invest 99:953-61. 1997
    ..XmnI, and MspI sites 5' of the apo AI gene and SstI site in the 3' untranslated region of exon 4 of the apo CIII gene in 18 FCH pedigrees, including 18 probands, 178 hyperlipidemic relatives, 210 normolipidemic relatives, and ..
  15. ncbi Severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to Hantaan virus infection
    Jihoe Kim
    School of Biotechnology, Yeungnam University, Gyeongsan 712 749, Seoul, Korea
    BMB Rep 43:535-40. 2010
    ..Low-density lipoprotein (LDL) particle size was smaller and the distribution was less homogeneous. Patients with HFRS in the oliguric phase had severely modified lipoproteins in composition and metabolism...
  16. pmc Plasma apolipoprotein C-III metabolism in patients with chronic kidney disease
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    J Lipid Res 52:794-800. 2011
    ..05 for all). Altered plasma apoC-III metabolism is a feature of dyslipidemia in moderate CKD. Modification of apoC-III catabolism may be an important therapeutic target for reducing cardiovascular disease risk in moderate CKD...
  17. pmc Lowering apolipoprotein CIII delays onset of type 1 diabetes
    Rebecka Holmberg
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 108:10685-9. 2011
    ..ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes...
  18. pmc Oxidative stress and inflammation in renal patients and healthy subjects
    Diana M Lee
    Lipid and Lipoprotein Studies, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e22360. 2011
    ..In conclusion, we have discovered a new inflammatory factor, TG48. It is characterized with TG rich in saturated fatty acids. Renal patients have increased TG48 than healthy controls...
  19. ncbi Haplotypes of the ApoA-I/C-III/A-IV gene cluster and familial combined hyperlipidemia
    E Tahvanainen
    Department of Biochemistry, National Public Health Institute, Helsinki Finland
    Arterioscler Thromb Vasc Biol 18:1810-7. 1998
    ..05) levels in spouses, which represent the general Finnish population. However, no evidence of direct involvement of any of these loci or their specific haplotypes in the expression of FCHL in the Finnish FCHL families was found...
  20. doi Lipoprotein abnormalities in patients with atherosclerotic renovascular disease
    Elzbieta Nowakowska Fortuna
    Department of Molecular and Clinical Medicine Nephrology, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Sweden
    Kidney Blood Press Res 34:311-9. 2011
    ..Patients with atherosclerotic renovascular disease (ARVD) have a high risk of cardiovascular death. The primary aim was to characterize abnormalities in apolipoprotein (Apo)-defined lipoprotein (Lp) subclasses in patients with ARVD...
  21. ncbi [Apolipoprotein C-II and C-III anomalies in normolipemic and hyperlipemic patients with chronic kidney failure]
    F Tornero
    Servicio de Nefrologia, Hospital General Virgen de la Luz, Cuenca
    Nefrologia 20:47-53. 2000
    ....
  22. doi Identification of potential serum biomarkers for Wilms tumor after excluding confounding effects of common systemic inflammatory factors
    Jiaxiang Wang
    Department of Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, Henan, People s Republic of China
    Mol Biol Rep 39:5095-104. 2012
    ..Taken together, these findings suggest that SAA1 and APO C-III are two potential biomarkers for Wilms tumor...
  23. ncbi Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis
    Philip E Morgan
    Free Radical Group, The Heart Research Institute, Camperdown, Sydeny, Australia
    Free Radic Res 41:1301-12. 2007
    ..Total apoCIII levels (assessed by ELISA) in lupus nephritis patients were significantly elevated compared to controls or non-renal SLE patients. Thus, levels of oxidized proteins and apoCIII may be useful biomarkers in SLE studies...
  24. pmc APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome
    Michael Miller
    University of Maryland Hospital and Veterans Affairs Medical Center, Baltimore, Maryland, USA
    Arch Med Res 38:444-51. 2007
    ..One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss ..
  25. ncbi ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
    Gery Gerritsen
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    J Lipid Res 46:1466-73. 2005
    ..Because apoC-III is a strong inhibitor of TG hydrolysis, we questioned whether Apoc3 deficiency might prevent the hyperlipidemia induced by apoE overexpression in vivo...
  26. ncbi Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men
    Jean Dallongeville
    Service d Epidémiologie et de Santé Publique INSERM U 508 and Departement d atherosclerose, lnstitut Pasteur de Lille, France
    Int J Cardiol 106:152-6. 2006
    ..The goal of the present study was to assess the impact of 4 single nucleotide polymorphisms (SNPs) of APOA5/A4/C3 gene cluster on lipid levels and coronary heart disease (CHD) risk in French men...
  27. ncbi Susceptibility to type 1 diabetes is associated with ApoCIII gene haplotypes
    John E Hokanson
    Department of Preventive Medicine and Biometrics, Box B119, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Diabetes 55:834-8. 2006
    ..00, 0.97, and 0.73, respectively; P = 0.03). This haplotype block contains an insulin response element. Screening for this haplotype may identify at-risk individuals, and this pathway may offer a target for prevention of type 1 diabetes...
  28. ncbi Association of lipoprotein lipase S447X, apolipoprotein E exon 4, and apoC3 -455T>C polymorphisms on the susceptibility to diabetic nephropathy
    M C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Genet 70:20-8. 2006
    ..The LPL S447X and apolipoprotein E (APOE) exon 4 polymorphisms affect TG levels, and the APOC3 -455T>C polymorphism affects LPL activity...
  29. doi Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia
    Sandrine Caron
    University Lille Nord de France, Lille, France
    Arterioscler Thromb Vasc Biol 31:513-9. 2011
    ..Apolipoprotein CIII (apoCIII), a regulator of hepatic and plasma triglyceride metabolism, is elevated in type 2 diabetes. In this study, we analyzed whether apoCIII is affected by altered glucose metabolism...
  30. ncbi The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype
    Puneetpal Singh
    Molecular Genetics Laboratory, Department of Human Biology, Punjabi University, Patiala 147002, Punjab, India
    Diab Vasc Dis Res 4:124-9. 2007
    ..45) even after adjustment for confounders. The findings in the present study suggest that each unit of P1-S2-X1 in diabetes increases the risk of CHD by a factor of 1.37+/-0.307 (beta + SE), which is manifest in its multiplicative mode...
  31. ncbi Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
    ..Genotyping of these polymorphisms may prove informative for assessment of the genetic risk for CAD in the absence or presence of type 2 diabetes...
  32. doi Effect of dietary saturated fatty acids on HNF-4α DNA binding activity and ApoCIII mRNA in sedentary rat liver
    Veronica Ceccarelli
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 3, 06122, Perugia, Italy
    Mol Cell Biochem 347:29-39. 2011
    ..In conclusion, we can speculate that dietary saturated fats, acting at apolipoprotein transcriptional level, may impact on the close relationship existing among high ApoCIII plasma level, dyslipidemia, and atherosclerosis...
  33. ncbi Role of thyroid hormone in the expression of apolipoprotein A-IV and C-III genes in rat liver
    Y C Lin-Lee
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030
    J Lipid Res 34:249-59. 1993
    ....
  34. ncbi Apolipoprotein A-I, A-II, B, C-II, and C-III in children with insulin-dependent diabetes mellitus
    N al Muhtaseb
    Department of Medicine, Faculty of Medicine, Kuwait
    Pediatrics 89:936-41. 1992
    ..We suggest that measurement of apo C-III level along with apo B and apo A-I in these patients may be a sensitive indicator to alterations in glycemic control...
  35. ncbi [Application of the box plot to evaluate serum lipid levels and apolipoprotein levels in patients with cerebral infarction and diabetes mellitus]
    G Konemori
    Department of Medicine, Futami Central Hospital, Hiroshima
    Nihon Ronen Igakkai Zasshi 27:22-7. 1990
    ..d. Compared to the control group, the ratio of LDL-C. to Apo B was lower (p less than 0.05) in the cerebral infarction group with diabetes mellitus and tended to be lower even in the diabetes mellitus-only group...
  36. ncbi Association of a DNA polymorphism in the apolipoprotein C-III gene with diverse hyperlipidaemic phenotypes
    H E Henderson
    Hum Genet 75:62-5. 1987
    ..These results suggest that the Sst-1 site is linked to a gene defect with a minor or subtle phenotypic effect which enhances the expression of a co-existent major monogenic defect of lipoprotein transport...
  37. ncbi Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes
    I A Haddad
    J Biol Chem 261:13268-77. 1986
    ..In addition, these results indicate that expression of the rat apoA-I, apoC-III, and apoA-IV genes is liver- and intestine-specific and regulated by fetal-, neonatal-, and aging-related factors...
  38. ncbi An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population
    Q Zeng
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Hum Genet 95:371-5. 1995
    ..The results suggest that S2-M2 chromosomes carry HTG susceptibility sequences that predate the separation of the Asian and Caucasian races...
  39. ncbi Vitamin A regulates the expression of apolipoprotein AI and CIII genes in the rat
    A Nagasaki
    Department of Agricultural Chemistry, Tokyo University of Agriculture, Japan
    Biochem Biophys Res Commun 205:1510-7. 1994
    ..Though the hepatic level of apo CIII mRNA was not affected by the vitamin A status, the intestinal level was positively regulated by vitamin A...
  40. ncbi Pattern of hyperlipoproteinemia in human nephrotic syndrome: influence of renal failure and diabetes mellitus
    J Joven
    Centre de Recerca Biomedica, Hospital de Sant Joan de Reus, Spain
    Nephron 64:565-9. 1993
    ....
  41. ncbi Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice
    Ilse Duivenvoorden
    TNO Prevention and Health, Gambius Laboratory, Leiden, Netherlands
    Diabetes 54:664-71. 2005
    ..b>Apoc3(-/-) mice and wild-type littermates were fed a high-fat (46 energy %) diet for 20 weeks...
  42. ncbi Alteration in rat apolipoprotein C-III gene expression and lipoprotein composition during inflammation
    P Shen
    Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia
    Inflammation 17:153-66. 1993
    ..A decrease in the concentration of apo A-I-containing HDL particles was also observed in these rats. The results indicate altered apolipoprotein gene expression associated with alterations in the size and composition of HDL particles...
  43. ncbi The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children
    H Takahashi
    Department of Pediatrics, Niigata University School of Medicine, Japan
    Acta Paediatr Jpn 38:634-9. 1996
    ..lipoprotein cholesterol (LDL-C), atherogenic index (AI), RLP-cholesterol (RLP-C), apoA1, apoA2, apoB, apoC2, apoC3, apoE and the ratio of apoB to apoA1 than non-overweight boys...
  44. ncbi Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation
    Y Andersson
    U325 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille et Faculté de Pharmacie, Universite de Lille II, Lille, France
    Arterioscler Thromb Vasc Biol 19:115-21. 1999
    ....
  45. ncbi Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 19:472-84. 1999
  46. ncbi Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study
    F Kee
    Division of Epidemiology, Queen s University of Belfast, UK
    Atherosclerosis 145:187-95. 1999
    ..In conclusion, in the ECTIM study, the apo A-I, C-III, A-IV gene cluster polymorphism is associated with neither circulating plasma variables nor MI survival...
  47. ncbi Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia
    Keiko Shimokata
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Atherosclerosis 172:167-73. 2004
    ..Genotyping of these three polymorphisms may prove informative for prediction of the genetic risk for CAD in men with nonfamilial hypercholesterolemia...
  48. ncbi [Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl)]
    S Tanaka
    Hiroshima Daigaku Shigaku Zasshi 8:168-75. 1975
  49. ncbi Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort
    Richard L Klein
    Department of Medicine, Division of Endocrinology, Metabolism, and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Diabetes Complications 19:18-25. 2005
    ..We investigated the associations of apolipoprotein C-III (apoCIII) protein and apoCIII gene variation with microvascular disease complications in Type 1 diabetes...
  50. ncbi Association of Sst I polymorphism in apolipoprotein C3 gene with hypertriglyceridaemia in coronary atherosclerotic heart disease and type II diabetes mellitus in Chinese population
    He Kun Liu
    Department of Medical Genetics, West China Hospital, Sichuan University, the State Key Laboratory of Biotherapy of Human Disease, Chengdu 610041, China
    Yi Chuan Xue Bao 32:11-8. 2005
    Several independent population studies have reported that the apolipoprotein C3 (APOC3) Sst I polymorphism in apolipoprotein (apo) A1 /C3/A4/A5 gene cluster is associated with Hypertriglyceridaemia (HTG)...

Research Grants2

  1. MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMES
    Michael Miller; Fiscal Year: 2003
    ..Further understanding of the molecular basis of isolated low HDL-C and its potential clinical sequelae (e.g., CAD), may therefore aid in the development of therapeutic strategies to effectively treat this disorder. ..
  2. NUTRITION ACADEMIC AWARD
    Michael Miller; Fiscal Year: 2004
    ..Compliance with ATP II and JNC VI recommendations will also be assessed. In addition, medical students' diets and blood lipid levels will be assessed and tracked. ..