apolipoprotein A I

Summary

Gene Symbol: apolipoprotein A I
Description: apolipoprotein A1
Alias: apoA-I, apolipoprotein A-I, apo-AI, apolipoprotein A-1, preproapolipoprotein A-I
Species: rat

Top Publications

  1. ncbi Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs
    F H Mahlberg
    Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129
    J Biol Chem 267:4541-50. 1992
  2. ncbi Repetitive elements in the third intron of murine apolipoprotein A-I gene
    A N Chiang
    Institute of Biochemistry, School of Life Science, National Yang Ming University, Taipei, Taiwan
    Biochem Mol Biol Int 43:989-96. 1997
  3. ncbi Apolipoprotein A-I increases association of cytosolic cholesterol and caveolin-1 with microtubule cytoskeletons in rat astrocytes
    Jin Ichi Ito
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Neurochem 97:1034-43. 2006
  4. ncbi Diversity of metabolic syndrome risk factors in obese children and adolescents
    G Bueno
    Departamento de Pediatria, Universidad de Zaragoza, C Domingo Miral s n, 50009 Zaragoza, Spain
    J Physiol Biochem 62:125-33. 2006
  5. ncbi Effect of complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone on protein biosynthesis in rat hepatocytes culture
    L E Panin
    Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk
    Bull Exp Biol Med 144:291-3. 2007
  6. pmc Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis
    Jennifer M P Woo
    Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Arthritis Res Ther 12:R93. 2010
  7. doi Apolipoprotein A-I attenuates renal ischemia/reperfusion injury in rats
    Ning Shi
    Department of Biochemistry, School of Pharmacy, Fudan University, PO Box 257, No 138 Yixueyuan Road, Shanghai 200032, China
    J Biomed Sci 15:577-83. 2008
  8. ncbi Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I
    J K Boyles
    Gladstone Foundation Laboratories for Cardiovascular Disease, Department of Pathology, University of California, San Francisco 94140 0608
    J Biol Chem 265:17805-15. 1990
  9. ncbi Apolipoprotein A-I induces translocation of cholesterol, phospholipid, and caveolin-1 to cytosol in rat astrocytes
    Jin Ichi Ito
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Biol Chem 277:7929-35. 2002
  10. doi Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression
    Lucia Carboni
    Neurosciences CEDD, GlaxoSmithKline, Verona, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 34:1037-48. 2010

Scientific Experts

  • Guangfu Chen
  • Sunita Dodani
  • Nosratola D Vaziri
  • A Lapolla
  • S Sethi
  • Kimiko Yamakawa-Kobayashi
  • Yuichi Inoue
  • Dolores Corella
  • N Vuilleumier
  • Iliya Lefterov
  • Alex E Roher
  • Sean G O'Neill
  • Jiwu Chang
  • D L Silver
  • Nora Morgado
  • Jin Ichi Ito
  • Geeta Datta
  • Zhenghao Zhang
  • X Wang
  • Shinji Yokoyama
  • Yuko Nagayasu
  • L E Panin
  • Juliana T Machado
  • Chiz Tzung Chang
  • Pierre Hibert
  • Mingyuan Tian
  • Ibrahim González-Marrero
  • Ho Jeong Lee
  • Sandra Ribeiro
  • Hongjie Li
  • Mary E Ziegler
  • Ashraf Mohamadkhani
  • Jennifer M P Woo
  • C Roger White
  • Bin Zhang
  • Lucia Carboni
  • Rui Lu
  • G M Anantharamaiah
  • E S Wang
  • Terry L Lewis
  • Tae Hoon Kim
  • Kyung Hyun Yoo
  • Ning Shi
  • Jonas Heilskov Graversen
  • Yue Li
  • Priscilla Jaichander
  • Man Ping Wu
  • Yunfeng Zhou
  • Michael Ehmann
  • Kuniko Mikuriya
  • Masahiko Iwaoka
  • Stephen J Peterson
  • G Bueno
  • R Ohashi
  • Simone C Sorkin
  • Koichi Kato
  • Daisy Sahoo
  • L M Polyakov
  • Rodrigo T Iborra
  • Fernanda B Fusco
  • Marisa Passarelli
  • Gabriela Castilho
  • Maria H Shimizu
  • Antonio C Seguro
  • Raphael S Pinto
  • Sergio Catanozi
  • Adriana Machado-Lima
  • Edna R Nakandakare
  • Yu Li
  • Chao Jung Chen
  • Chu Huang Chen
  • Emilia M Carmona-Calero
  • Agustín Castañeyra-Ruiz
  • Chao Yuh Yang
  • Delphine Prunier-Mirebeau
  • Olivia Beseme
  • Rafael Castro
  • Juan R Hernández-Fernaud
  • Alain Furber
  • Sophie Tamareille
  • Linhui Wang
  • Delphine Lamon
  • Maggy Chwastyniak
  • Leandro Castañeyra-Ruiz
  • Xiong Zhang
  • Chia Ying Chen
  • Hector de Paz-Carmona
  • Fabrice Prunier
  • Agustín Castañeyra-Perdomo
  • Florence Pinet

Detail Information

Publications76

  1. ncbi Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs
    F H Mahlberg
    Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129
    J Biol Chem 267:4541-50. 1992
    ..These results led us to propose a new model regarding the influence of multiple kinetic pools of cholesterol on the regulation of cholesterol desorption from the cell membrane...
  2. ncbi Repetitive elements in the third intron of murine apolipoprotein A-I gene
    A N Chiang
    Institute of Biochemistry, School of Life Science, National Yang Ming University, Taipei, Taiwan
    Biochem Mol Biol Int 43:989-96. 1997
    ..These repetitive motifs are very similar to the sequences flanking human Alu and rodent B1 repetitive elements, although no evidence for the existence of Alu or B1 was found near the peculiar repetitive DNA sequences in apoA-I gene...
  3. ncbi Apolipoprotein A-I increases association of cytosolic cholesterol and caveolin-1 with microtubule cytoskeletons in rat astrocytes
    Jin Ichi Ito
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Neurochem 97:1034-43. 2006
    ....
  4. ncbi Diversity of metabolic syndrome risk factors in obese children and adolescents
    G Bueno
    Departamento de Pediatria, Universidad de Zaragoza, C Domingo Miral s n, 50009 Zaragoza, Spain
    J Physiol Biochem 62:125-33. 2006
    ..05) and Apo Al decreased significantly (p < 0.05) in both sexes when MS was present. Adequate metabolic syndrome risk factors criteria, mainly cut-off values, need to be defined in the European paediatric population...
  5. ncbi Effect of complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone on protein biosynthesis in rat hepatocytes culture
    L E Panin
    Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk
    Bull Exp Biol Med 144:291-3. 2007
    ..Hence, the observed changes are not organ-specific for this steroid. Our results suggest that this mechanism of regulation play an important role in intracellular regeneration and proliferation...
  6. pmc Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis
    Jennifer M P Woo
    Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Arthritis Res Ther 12:R93. 2010
    ....
  7. doi Apolipoprotein A-I attenuates renal ischemia/reperfusion injury in rats
    Ning Shi
    Department of Biochemistry, School of Pharmacy, Fudan University, PO Box 257, No 138 Yixueyuan Road, Shanghai 200032, China
    J Biomed Sci 15:577-83. 2008
    ..It seems likely that ApoA-I protects kidney from I/R injury by inhibiting inflammatory cytokines release and neutrophil infiltration and activation...
  8. ncbi Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I
    J K Boyles
    Gladstone Foundation Laboratories for Cardiovascular Disease, Department of Pathology, University of California, San Francisco 94140 0608
    J Biol Chem 265:17805-15. 1990
    ..The results from this study provide evidence that several different apolipoproteins from various sources may play a role in lipid transport within neural tissues...
  9. ncbi Apolipoprotein A-I induces translocation of cholesterol, phospholipid, and caveolin-1 to cytosol in rat astrocytes
    Jin Ichi Ito
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Biol Chem 277:7929-35. 2002
    ....
  10. doi Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression
    Lucia Carboni
    Neurosciences CEDD, GlaxoSmithKline, Verona, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 34:1037-48. 2010
    ..An open-ended approach based on a proteomic analysis of serum was combined with the evaluation of depression-associated proteins...
  11. pmc Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin
    Priscilla Jaichander
    Division of Cardiothoracic Surgery, Ohio State University Medical Center, Columbus, OH, USA
    J Lipid Res 49:2142-8. 2008
    ....
  12. doi Anti-apolipoprotein A-1 IgG as an independent cardiovascular prognostic marker affecting basal heart rate in myocardial infarction
    Nicolas Vuilleumier
    Service of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Geneva 14, Switzerland
    Eur Heart J 31:815-23. 2010
    ..Anti-apoA-1 IgG have been reported in MI without autoimmune disease, but their clinical significance remains undetermined...
  13. pmc Apolipoprotein A1 and C-terminal fragment of α-1 antichymotrypsin are candidate plasma biomarkers associated with acute renal allograft rejection
    Mary E Ziegler
    Department of Pathology and Laboratory Medicine, UCLA School of Public Health, Los Angeles, CA 90095, USA
    Transplantation 92:388-95. 2011
    ..Needle biopsies are invasive and associated with patient morbidity. Thus, it is desirable to develop noninvasive tests to predict and diagnose rejection...
  14. pmc A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve
    J K Boyles
    Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140 0608
    J Clin Invest 83:1015-31. 1989
    ....
  15. doi N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1
    Juliana T Machado
    Lipids Laboratory LIM 10, Faculty of Medical Sciences, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil
    Atherosclerosis 237:343-52. 2014
    ..NAC may contribute to attenuate the deleterious effects of CKD-albumin on lipid accumulation in macrophages helping to prevent atherogenesis in CKD...
  16. doi Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes
    Jin Ichi Ito
    Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Biochim Biophys Acta 1841:1234-40. 2014
    ....
  17. pmc Apolipoprotein a-I is a potential mediator of remote ischemic preconditioning
    Pierre Hibert
    L UNAM Université, Angers, France Laboratoire Cardioprotection, Remodelage et Thrombose, Universite d Angers, Angers, France
    PLoS ONE 8:e77211. 2013
    ..Despite convincing evidence of the critical role played by circulating humoral mediators, their actual identities remain unknown. In this study, we aimed to identify RIPC-induced humoral mediators using a proteomic approach...
  18. doi Curcumin induces ABCA1 expression and apolipoprotein A-I-mediated cholesterol transmembrane in the chronic cerebral hypoperfusion aging rats
    Mingyuan Tian
    Department of Pathology, Chongqing Medical University, Chongqing 400016, China, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China, Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China
    Am J Chin Med 41:1027-42. 2013
    ....
  19. doi Antibodies to apolipoprotein A-I, high-density lipoprotein, and C-reactive protein are associated with disease activity in patients with systemic lupus erythematosus
    Sean G O'Neill
    University College London, London, UK
    Arthritis Rheum 62:845-54. 2010
    ..We undertook this study to examine whether levels of these antibodies rise in association with increased SLE disease activity...
  20. doi Oxidized ApoC1 on MALDI-TOF and glycated-ApoA1 band on gradient gel as potential diagnostic tools for atherosclerotic vascular disease
    Chiz Tzung Chang
    L5 Research Center, China Medical University Hospital, Taichung 40447, Taiwan
    Clin Chim Acta 420:69-75. 2013
    ....
  21. ncbi Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles
    Y Furukawa
    Department of Food Chemistry, Faculty of Agriculture, Tohoku University, Miyagi
    J Biochem 111:413-8. 1992
    ..This suggests that the mixture of rat enzyme, rat apo-A-I, and vesicles, which are the major components in the rat lecithin-cholesterol acyltransferase reaction, forms a stronger complex than do the components of the human reaction...
  22. doi Trimerization of apolipoprotein A-I retards plasma clearance and preserves antiatherosclerotic properties
    Jonas Heilskov Graversen
    ProteoPharma ApS and Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    J Cardiovasc Pharmacol 51:170-7. 2008
    ..Direct administration of recombinant high-mass apoA-I analogues with retarded clearance is therefore a potential novel therapeutic approach for atherosclerotic plaque stabilization...
  23. ncbi Nonenzymatically glycated lipoprotein ApoA-I in plasma of diabetic and nephropathic patients
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Universita di Padova, Padova, Italy
    Ann N Y Acad Sci 1126:295-9. 2008
    ....
  24. doi Human ApoA-I overexpression diminishes LPS-induced systemic inflammation and multiple organ damage in mice
    Yue Li
    Department of Biochemistry, School of Pharmacy, Fudan University, Shanghai 200032, China
    Eur J Pharmacol 590:417-22. 2008
    ..Such effect may attribute partly to the suppression of inflammatory cytokine release and reduction of CD14 expression...
  25. ncbi Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats
    Stephen J Peterson
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 322:514-20. 2007
    ....
  26. pmc Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats
    Yunfeng Zhou
    Department of Physiology and Pathophysiology, Peking University Health Science Center, 38 Xueyuan Rd, Beijing, China
    Am J Physiol Renal Physiol 295:F662-71. 2008
    ..Activation of SREBP-1 transcription factor may represent an underlying molecular mechanism of hyperlipidemia in NS...
  27. doi Repeated intravenous infusion of human apolipoprotein(a) kringle V is associated with reversible dose-dependent acute tubulointerstitial nephritis without affecting glomerular filtration function
    Ho Jeong Lee
    Cancer Biology Team, Mogam Biotechnology Research Institute, 341 Bojeong dong, Giheung gu, Yongin 446 799, Republic of Korea
    Toxicol Lett 212:298-306. 2012
    ....
  28. pmc Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats
    Zhenghao Zhang
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Heart Circ Physiol 297:H866-73. 2009
    ..Increased plasma HDL in 4F-treated CLP rats was associated with an improvement in CO and reduced mortality. It is proposed that protective effects of 4F are related to its ability to prevent the sepsis-induced reduction in plasma HDL...
  29. doi Identification of apolipoproteinA1 reduction in the polycystic kidney by proteomics analysis of the Mxi1-deficient mouse
    Kyung Hyun Yoo
    Department of Biological Science, Sookmyung Women s University, Seoul, Korea
    Proteomics 9:3824-32. 2009
    ..These results indicate that expression of proteins related with inflammation and renal fibrosis changes by Mxi1 inactivation in polycystic kidney...
  30. pmc High blood pressure effects on the blood to cerebrospinal fluid barrier and cerebrospinal fluid protein composition: a two-dimensional electrophoresis study in spontaneously hypertensive rats
    Ibrahim González-Marrero
    Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, Ofra s n, 38071 La Laguna, Tenerife, Spain
    Int J Hypertens 2013:164653. 2013
    ....
  31. doi Oxidized low-density lipoprotein and lipoprotein(a) levels in chronic kidney disease patients under hemodialysis: influence of adiponectin and of a polymorphism in the apolipoprotein(a) gene
    Sandra Ribeiro
    Faculdade Farmácia, Serviço de Bioquímica, Universidade do Porto, Porto, Portugal
    Hemodial Int 16:481-90. 2012
    ..Apo(a) alleles with a lower number of repetitions are more frequent in patients with higher Lp(a)...
  32. pmc HDL Mimetic Peptide Administration Improves Left Ventricular Filling and Cardiac output in Lipopolysaccharide-Treated Rats
    Geeta Datta
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Clin Exp Cardiolog 2:. 2011
    ..CONCLUSIONS: The ability of 4F to reduce inflammation and improve cardiac performance in LPS-treated rats may be due to its capacity to neutralize endotoxin and prevent adverse changes in HDL composition and function...
  33. pmc Laser microdissection and mass spectrometry-based proteomics aids the diagnosis and typing of renal amyloidosis
    Sanjeev Sethi
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Kidney Int 82:226-34. 2012
    ....
  34. pmc Amelioration of nephropathy with apoA-1 mimetic peptide in apoE-deficient mice
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 25:3525-34. 2010
    ..Given the central role of oxidative stress and inflammation in progression of renal disease, we hypothesized that apoA-1 mimetic peptide, D-4F, may attenuate renal lesions in apoE(-/-) mice...
  35. pmc Identification of Apo-A1 as a biomarker for early diagnosis of bladder transitional cell carcinoma
    Hongjie Li
    Research Laboratory for Tumor Immunity of Tianjin Urological Institute, Second Hospital of Tianjin Medical University, Tianjin, China
    Proteome Sci 9:21. 2011
    ..Availability of urinary tumor biomarkers represents a convenient alternative for early detection and disease surveillance because of its direct contact with the tumor and sample accessibility...
  36. pmc Comparison of serum apolipoprotein A-I between Chinese multiple sclerosis and other related autoimmune disease
    Bin Zhang
    Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang east Road, Guangzhou, 510260 Guangdong Province, China
    Lipids Health Dis 9:34. 2010
    ..However, the change of serum apoA-I levels in multiple sclerosis (MS) patients is unknown...
  37. doi Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson's disease
    E S Wang
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
    Acta Neurol Scand 122:350-9. 2010
    ..However, no reliable biomarker has been identified to date. This study is aimed to identify proteins that might serve as potential biomarkers for PD diagnosis or pathogenesis...
  38. pmc Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Biomarkers 14:493-501. 2009
    ..For the discrimination of AD from NADD subjects, measurement of Abeta1-42 alone was superior...
  39. doi Role of lung apolipoprotein A-I in idiopathic pulmonary fibrosis: antiinflammatory and antifibrotic effect on experimental lung injury and fibrosis
    Tae Hoon Kim
    Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University, Bucheon Hospital, 1174 Jung dong, Wonmi Ku, Bucheon, Kyeonggi Do, South Korea
    Am J Respir Crit Care Med 182:633-42. 2010
    ..Idiopathic pulmonary fibrosis (IPF) is caused by alterations in expression of proteins involved in multiple pathways, including matrix deposition, inflammation, injury, and repair...
  40. doi Characterization of apolipoprotein A-I as a potential biomarker for cholangiocarcinoma
    X Wang
    Key laboratory for Cell Proliferation and Regulation Biology Ministry of Education Universities Confederated Institute of Proteomics, Beijing, China
    Eur J Cancer Care (Engl) 18:625-35. 2009
    ..Therefore, it suggested that ApoA-I could be a potential useful biomarker for CC...
  41. doi Identification of differently expressed genes in chemical carcinogen-induced rat bladder cancers
    Guangfu Chen
    Department of Urology, the General Hospital of the Chinese People s Liberation Army, Beijing, 100853, China
    J Huazhong Univ Sci Technolog Med Sci 29:220-6. 2009
    ..The increased expressions of the identified genes may play an important role in the chemically induced bladder carcinogenesis...
  42. ncbi Association of low serum levels of apolipoprotein A-I with adverse outcomes in patients with nonischemic heart failure
    Masahiko Iwaoka
    Department of Internal Medicine II, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    J Card Fail 13:247-53. 2007
    ..This study examined whether apoA-I levels may also provide prognostic information in patients with nonischemic heart failure...
  43. doi ApoA-1 mimetic peptide reverses uremia-induced upregulation of pro-atherogenic pathways in the aorta
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Calif, USA ndvaziri uci edu
    Am J Nephrol 32:201-11. 2010
    ..We hypothesized that long-term administration of ApoA-1 mimetic peptide, L4F, may ameliorate inflammation and oxidative stress in the conduit arteries in experimental CKD...
  44. pmc Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice
    Iliya Lefterov
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 285:36945-57. 2010
    ..We conclude that lack of apoA-I aggravates the memory deficits in APP/PS1ΔE9 mice in parallel to significantly increased cerebral amyloid angiopathy...
  45. pmc Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease
    Terry L Lewis
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:36958-68. 2010
    ..These findings suggest that elevating plasma apoA-I/HDL levels may be an effective approach to preserve cognitive function in patients with AD...
  46. pmc Metabolic syndrome in South Asian immigrants: more than low HDL requiring aggressive management
    Sunita Dodani
    Center for Post Polio Rehabilitation, 2308 W 127 street, Leawood, KS 66209, USA
    Lipids Health Dis 10:45. 2011
    ..There is need to explore and understand non-traditional risk factors with special focus on Dys-HDL, knowing that SAIs have low HDL levels. Large prospective studies are needed to further strengthen current study results...
  47. doi Plasma myeloperoxidase activity and apolipoprotein A-1 expression in chronic hepatitis B patients
    Ashraf Mohamadkhani
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran
    Arch Iran Med 14:254-8. 2011
    ..This study aims to evaluate the level of plasma myeloperoxidase as well as the pattern of plasma proteins in patients with chronic hepatitis B...
  48. pmc Comparative analysis of repeated sequences in rat apolipoproteins A-I, A-IV, and E
    M S Boguski
    Proc Natl Acad Sci U S A 82:992-6. 1985
    ..Diversification of a duplicated ancestral sequence has resulted in three lipid-binding proteins with distinct and shared functions...
  49. ncbi Distribution of tocopherol and apolipoprotein A-I immunoreactivity in rat liver chromatin
    L E Panin
    Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia
    Membr Cell Biol 11:631-40. 1998
    ..A similar distribution pattern was observed for alpha-tocopherol. It is concluded that blood serum lipoproteins, primarily HDL, may transport tocopherol and other lipids into cell nuclei...
  50. ncbi Quantification of apolipoprotein AI-containing lipoprotein particles in non-insulin-dependent diabetes mellitus
    E Contiero
    Department of Biology, University of Padua, Italy
    Diabetes Res Clin Pract 39:201-9. 1998
    ..005, for both variables). On the contrary, levels of LpAI/AII (lipoprotein particles containing both apolipoprotein AI and AII) were significantly increased in diabetic patients (P < 0.005)...
  51. ncbi Predominance of large low density lipoprotein particles and lower fractional esterification rate of cholesterol in high density lipoprotein in children with insulin-dependent diabetes mellitus
    T Ohta
    Department of Paediatrics, Kumamoto University School of Medicine, Japan
    Eur J Pediatr 157:276-81. 1998
    ..FERHDL, which reflects the particle size distribution of HDL, was significantly lower in diabetic children than in controls, which suggests that diabetic children had larger HDL particles...
  52. ncbi A polymorphism in the human apolipoprotein AI promoter region: a study in hypertriglyceridaemic patients
    E W Needham
    Department of Human Metabolism and Genetics, St Bartholomew s Hospital, London, UK
    Hum Hered 44:94-9. 1994
    ..On the basis of these results, the G-75-->A mutation is unlikely to be aetiological in predisposing to hypertriglyceridaemia...
  53. ncbi Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids
    L Berthou
    INSERM U 325, Departement d Atherosclerose, Institut Pasteur, Lille, France
    Eur J Biochem 232:179-87. 1995
    ..In contrast, only fenofibric acid, but not the other fibrates or fatty acids tested, decrease apo A-II gene expression in vitro...
  54. ncbi The primary translation product of rat intestinal apolipoprotein A-I mRNA is an unusual preproprotein
    J I Gordon
    J Biol Chem 257:971-8. 1982
    ..However, post-translational proteolytic processing of proapolipoprotein A-I must be unique, and could play a role in the formation of nascent high density lipoprotein particles...
  55. ncbi Cloning and structure analysis of the rat apolipoprotein A-I cDNA
    J E Poncin
    Eur J Biochem 140:493-8. 1984
    ..Both mature protein amino-terminal regions are very homologous, suggesting that this particular domain could be involved in lipid/protein binding or lecithin-cholesterol acyltransferase activation...
  56. ncbi Influence of genetic variation at the apo A-I gene locus on lipid levels and response to diet in familial hypercholesterolemia
    R F Carmena-Ramon
    Department of Medicine, Hospital Clinico, University of Valencia, Spain
    Atherosclerosis 139:107-13. 1998
    We have examined the apo AI - 75 (G/A) and apo AI + 83(MspI +/-) polymorphisms at the APOA1 gene locus for associations with plasma lipid levels and response to an NCEP-I diet in 69 (44 women, 25 men) heterozygotes for familial ..
  57. ncbi Variant apolipoprotein AI as a major constituent of a human hereditary amyloid
    W C Nichols
    Department of Medical Genetics, Indiana University School of Medicine, Indianapolis
    Biochem Biophys Res Commun 156:762-8. 1988
    ..This is the first report of an apolipoprotein as a major amyloid constituent in a form of autosomal dominant hereditary amyloidosis in humans...
  58. ncbi Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes
    I A Haddad
    J Biol Chem 261:13268-77. 1986
    ..In addition, these results indicate that expression of the rat apoA-I, apoC-III, and apoA-IV genes is liver- and intestine-specific and regulated by fetal-, neonatal-, and aging-related factors...
  59. ncbi Leupeptin as a tool for the detection of the sites of catabolism of rat high-density lipoprotein apolipoproteins A-I and E
    F M van 't Hooft
    Biochim Biophys Acta 834:75-84. 1985
    ....
  60. ncbi Influence of development, estrogens, and food intake on apolipoprotein A-I, A-II, and E mRNA in rat liver and intestine
    B Staels
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    J Lipid Res 30:1137-45. 1989
    ..None of these treatments caused any change in liver apoE mRNA levels. Serum apoA-I levels increased upon OVX, while serum apoE did not change. EE provoked a dose-dependent decrease of both apolipoproteins in serum...
  61. ncbi [Serum apolipoprotein AI, B levels in patients with coronary diseases]
    Y He
    Fourth Military Medical University, Xian
    Zhonghua Xin Xue Guan Bing Za Zhi 18:217-9, 254. 1990
    ..g. total cholesterol, triglycerides, LDL-C and HDL-C) in estimating the degree of coronary artery stenosis and the differentiation of CAD from other diseases...
  62. ncbi Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states
    A Panduro
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461
    Biochemistry 29:8430-5. 1990
    ..These changes are similar in the three pathophysiologic states and seem to occur through a combination of transcriptional and posttranscriptional mechanisms...
  63. ncbi The compositional abnormalities of lipoproteins in diabetic renal failure
    P O Attman
    Department of Nephrology, Sahlgrenska University Hospital, University of Goteborg, Sweden
    Nephrol Dial Transplant 13:2833-41. 1998
    ..The aim of the study was to explore the specific compositional lipoprotein abnormalities in patients with insulin-dependent DN in comparison with diabetic patients without nephropathy and non-diabetic CRF patients...
  64. ncbi Frequent occurrence of hypoalphalipoproteinemia due to mutant apolipoprotein A-I gene in the population: a population-based survey
    K Yamakawa-Kobayashi
    Department of Medical Genetics, Institute of Basic Medical Sciences, Institute of Community Medicine and Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Hum Mol Genet 8:331-6. 1999
    ..4-14. 4%) in the subjects with low HDL cholesterol levels and 0.3% (95% CI: 0.1-0.8%) in the Japanese population. This suggests that familial hypoalphalipoproteinemia due to apo A-I gene mutations is relatively common...
  65. ncbi Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover
    D L Silver
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 274:4140-6. 1999
    ..The studies reveal a specific HDL particle catabolic pathway that is down-regulated in ob/ob mice and suggest that HDL apolipoprotein turnover may be regulated by obesity and/or leptin signaling...
  66. ncbi Inhibition of the acid lipase activity by apolipoprotein A-I in the presence of lysosomal proteases
    Y Inoue
    Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
    Biosci Biotechnol Biochem 63:937-9. 1999
    ..We demonstrated that apo A-I could effectively inhibit the acid lipase activity even in the presence of the lysosomal proteases using the hepatic lysosomal fraction...
  67. ncbi Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study
    F Kee
    Division of Epidemiology, Queen s University of Belfast, UK
    Atherosclerosis 145:187-95. 1999
    ..In conclusion, in the ECTIM study, the apo A-I, C-III, A-IV gene cluster polymorphism is associated with neither circulating plasma variables nor MI survival...
  68. ncbi [Study on plasma lipids, apolipoprotein A1, apolipoprotein B100 in simple obese children]
    H Zhu
    Faculty of Clinic Nutrition, School of Public Health, SUMS, Guangzhou 510089, China
    Wei Sheng Yan Jiu 29:104-5. 2000
    ..05). The results suggested that metabolic disorder of lipid and apolipoprotein took place in obese children. The disorder which may increase the risk of AS should be paid great attention...
  69. ncbi ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes
    Daisy Sahoo
    Departments of Pediatrics, CIHR Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada
    J Lipid Res 45:1122-31. 2004
    ..The results also suggest that diversion of hepatocyte cholesterol into the "reverse" cholesterol transport pathway diminishes cholesterol availability for apoB-containing lipoprotein secretion by the liver...
  70. ncbi SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 25:341-90. 2005
    ..In summary, there is need for both large population studies and well-standardized intervention studies...
  71. ncbi Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat
    Nora Morgado
    Laboratorio de Lípidos y Antioxidantes, INTA, Universidad de Chile, Santiago
    Ann Nutr Metab 49:397-406. 2005
    ..On the other hand, omega-3 PUFAs decrease plasma HDL levels compared to other fatty acids, which may suggest an effect on reverse cholesterol transport...
  72. ncbi Reverse cholesterol transport and cholesterol efflux in atherosclerosis
    R Ohashi
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston 77030, USA
    QJM 98:845-56. 2005
    ..Further research on new modifying factors for RCT and cholesterol efflux is warranted...
  73. ncbi APOA1 polymorphisms are associated with variations in serum triglyceride concentrations in hypercholesterolemic individuals
    Simone C Sorkin
    Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Clin Chem Lab Med 43:1339-45. 2005
    ..We have investigated whether APOA1 common variants are also associated with variations in basal triglyceride serum concentrations and response to atorvastatin in individuals with hypercholesterolemia...
  74. ncbi Identification of potential markers for the detection of pancreatic cancer through comparative serum protein expression profiling
    Michael Ehmann
    Department of General Surgery, University of Heidelberg, INF 110, D 69120 Heidelberg, Germany
    Pancreas 34:205-14. 2007
    ..Noninvasive tools for the diagnosis, prognosis, and monitoring of this disease are of urgent need. The purpose of this study was to identify and validate new biomarkers in PCa patient serum samples...
  75. ncbi Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry
    Kuniko Mikuriya
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Int J Oncol 30:849-55. 2007
    ..These glycolytic proteins and transgelin, were confirmed by Western blotting and immunohistochemistry...
  76. ncbi Differential regulation of hepatic apolipoprotein A-I and A-II gene expression by thyroid hormone in rat liver
    W Strobl
    Department of Pediatrics, Univ of Vienna, Austria
    Atherosclerosis 97:161-70. 1992
    ..We conclude that the apo A-I and apo A-II genes in rat liver respond differently to both acute and chronic hyperthyroidism and that their expression is regulated at transcriptional and posttranscriptional levels...

Research Grants2

  1. Therapeutic potential-LXR ligands in Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2005
    ..abstract_text> ..
  2. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..