Bdkrb2

Summary

Gene Symbol: Bdkrb2
Description: bradykinin receptor B2
Alias: B2BKR, B2BRA, B2 bradykinin receptor, B2R, BK-2 receptor, bradykinin receptor, beta 2
Species: rat

Top Publications

  1. ncbi International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences
    L M Fredrik Leeb-Lundberg
    Division of Cellular and Molecular Pharmacology, Department of Experimental Medical Science, Lund University, BMC, A12, SE 22184 Lund, Sweden
    Pharmacol Rev 57:27-77. 2005
  2. doi Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats
    Hongfei Sang
    Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China
    Eur J Neurosci 43:53-65. 2016
  3. doi Up-regulation of the kinin B2 receptor pathway modulates the TGF-β/Smad signaling cascade to reduce renal fibrosis induced by albumin
    Areli Cárdenas
    Department of Nephrology, Universidad Austral de Chile, Valdivia, Chile
    Peptides 73:7-19. 2015
  4. doi Bradykinin B2 receptor in the adrenal medulla of male rats and mice: glucocorticoid-dependent increase with immobilization stress
    Regina Nostramo
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595
    Endocrinology 154:3729-38. 2013
  5. pmc Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor
    Xin Jin
    Faculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Sci Signal 6:ra73. 2013
  6. pmc Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage
    W Torres-Rivera
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00956, USA
    Neuroscience 247:273-9. 2013
  7. doi Change in central kinin B2 receptor density after exercise training in rats
    Ariadiny Lima Caetano
    Department of Physiological Sciences, Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil
    Auton Neurosci 158:71-8. 2010
  8. doi Age-related changes in kallikreins-kinins system in rat corpus cavernosum
    T Wang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Int J Androl 34:33-40. 2011
  9. doi A novel bioassay for detecting GPCR heterodimerization: transactivation of beta 2 adrenergic receptor by bradykinin receptor
    Karla K V Haack
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA
    J Biomol Screen 15:251-60. 2010
  10. pmc Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors
    M Abdouh
    Guy Bernier Research Centre, Maisonneuve Rosemont Hospital, Montreal, Canada
    Br J Pharmacol 154:136-43. 2008

Scientific Experts

  • F Qadri
  • Thomas K Monsees
  • Esther L Sabban
  • Masao Kakoki
  • Laura Nurmi
  • Hélène C Seegers
  • S Zausinger
  • John S Smeda
  • K Yayama
  • Nikolaus Plesnila
  • Hendrik Freise
  • L M Fredrik Leeb-Lundberg
  • Magdalena Bujalska
  • N S Hopkinson
  • Kumi Moriyama
  • N N Atanassova
  • Johan Duchene
  • Yan Tan
  • Cleber A Trujillo
  • Jérôme Côté
  • Martin Savard
  • Brice Ongali
  • Hongfei Sang
  • Joao B Pesquero
  • Inka Liesmaa
  • Areli Cárdenas
  • Arvi Duka
  • Xin Jin
  • Regina Nostramo
  • W Torres-Rivera
  • Jian Lu
  • Ling Liu
  • Seul Ki Lim
  • Stefânia Forner
  • S Mukae
  • Jihong Dai
  • Carlos D Figueroa
  • Maria Martha Campos
  • Antonio Grilo
  • Dongdong Sun
  • T Wang
  • Gisela Segond von Banchet
  • Karla K V Haack
  • Ariadiny Lima Caetano
  • Fiona A Russell
  • Telma T Schwindt
  • Henning Ulrich
  • Réjean Couture
  • Qingmin Chen
  • Joost P Schanstra
  • Jean Loup Bascands
  • Jean Pierre Girolami
  • Christiane Pecher
  • Cornelia M Bertram
  • Chien Ting Chen
  • Jakob L Hansen
  • Fernand Gobeil
  • Min Tang
  • Veronica Bovenzi
  • S W Woo
  • M Abdouh
  • M Petcu
  • Antonio H Martins
  • Viviani Milan Ferreira Rastelli
  • Sema Hayriye Sivritas
  • R Couture
  • Jozefa Dabek
  • Samir S El-Dahr
  • Jorma O Kokkonen
  • Heikki Ruskoaho
  • Hanna K Leskinen
  • Ken A Lindstedt
  • Petri T Kovanen
  • Peter M Abadir
  • Haralambos Gavras
  • Thomas Walther
  • Ayad A Jaffa
  • Irene Gavras
  • Laimute Taraseviciene-Stewart
  • Ekaterina Kintsurashvili
  • Chiharu Imai
  • Bikramjit Chopra
  • Koh Ichi Yuhki
  • Gaétan Thibault
  • R Gama Landgraf
  • K M Ellis
  • I M Sainz
  • Jean Pierre Esteve
  • Shuhong Yu
  • Ruibing Guo

Detail Information

Publications90

  1. ncbi International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences
    L M Fredrik Leeb-Lundberg
    Division of Cellular and Molecular Pharmacology, Department of Experimental Medical Science, Lund University, BMC, A12, SE 22184 Lund, Sweden
    Pharmacol Rev 57:27-77. 2005
    ..This review is a comprehensive presentation of our current understanding of these receptors in terms of molecular and cell biology, physiology, pharmacology, and involvement in human disease and drug development...
  2. doi Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats
    Hongfei Sang
    Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China
    Eur J Neurosci 43:53-65. 2016
    ..In this study, we hypothesized that bradykinin 1 receptor (B1R) and bradykinin 2 receptor (B2R) would be upregulated and participate in the regulation of diabetic ischaemic stroke...
  3. doi Up-regulation of the kinin B2 receptor pathway modulates the TGF-β/Smad signaling cascade to reduce renal fibrosis induced by albumin
    Areli Cárdenas
    Department of Nephrology, Universidad Austral de Chile, Valdivia, Chile
    Peptides 73:7-19. 2015
    ..Since bradykinin and the kinin B2 receptor (B2R) belong to a renoprotective system with mechanisms still unclarified, we investigated its anti-fibrotic role in the ..
  4. doi Bradykinin B2 receptor in the adrenal medulla of male rats and mice: glucocorticoid-dependent increase with immobilization stress
    Regina Nostramo
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595
    Endocrinology 154:3729-38. 2013
    Bradykinin, acting via the bradykinin B2 receptor (B2R), is a potent stimulator of adrenomedullary catecholamine biosynthesis and release and likely plays an important role in the adrenomedullary stress response...
  5. pmc Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor
    Xin Jin
    Faculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Sci Signal 6:ra73. 2013
    ..The junctional signaling complex enabled ANO1-mediated excitation in response to specific Ca(2+)signals rather than to global changes in intracellular Ca(2+). ..
  6. pmc Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage
    W Torres-Rivera
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00956, USA
    Neuroscience 247:273-9. 2013
    The kinin-B2 receptor (B2BKR) activated by its endogenous ligand bradykinin participates in various metabolic processes including the control of arterial pressure and inflammation...
  7. doi Change in central kinin B2 receptor density after exercise training in rats
    Ariadiny Lima Caetano
    Department of Physiological Sciences, Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil
    Auton Neurosci 158:71-8. 2010
    ..In the lamina 2, B2 receptor might be involved in the exercise-induced hypotension...
  8. doi Age-related changes in kallikreins-kinins system in rat corpus cavernosum
    T Wang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Int J Androl 34:33-40. 2011
    ..Tissue kallikrein-I (KLKI) and kinin B2 receptor (B2R) mRNA in CC and thoracic aorta were detected by real-time polymerase chain reaction (PCR)...
  9. doi A novel bioassay for detecting GPCR heterodimerization: transactivation of beta 2 adrenergic receptor by bradykinin receptor
    Karla K V Haack
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA
    J Biomol Screen 15:251-60. 2010
    ..This is the first evidence of Bk2R/beta(2)AR physical interaction, forming a functional heterodimer. The oocyte system may prove highly useful for exploration of GPCR heterodimerization and the functional consequences thereof...
  10. pmc Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors
    M Abdouh
    Guy Bernier Research Centre, Maisonneuve Rosemont Hospital, Montreal, Canada
    Br J Pharmacol 154:136-43. 2008
    ..We investigated whether or not kinin receptors play a role in diabetic blood-retinal barrier breakdown, which is a leading cause of vision loss...
  11. ncbi Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X
    Jozefa Dabek
    Department of Cardiology, Medical University of Silesia, Ziolowa 47, 40 635 Katowice, Poland
    Scand Cardiovasc J 41:391-6. 2007
    ..Their effects are mediated by two receptors: B1 and B2. The aim of the study was to assess gene expression of kinin receptors in peripheral blood mononuclear cells (PBMC) from patients with CSX...
  12. ncbi +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Road, London SW3 6NP, United Kingdom
    Am J Clin Nutr 83:912-7. 2006
    ....
  13. ncbi Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists
    R Gama Landgraf
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1730, 05508 900 Sao Paulo, Brazil
    Inflamm Res 53:78-83. 2004
    ..The effect of bradykinin (B(1) or B(2)) receptor antagonists was studied in allergic and immune-complex-induced lung inflammation...
  14. ncbi Combined effect of bradykinin B2 and neurokinin-1 receptor activation on endothelial cell proliferation in acute synovitis
    Hélène C Seegers
    Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
    FASEB J 18:762-4. 2004
    ..These findings demonstrate that substance P and bradykinin can act on NK1 and B2 receptors, respectively, to promote endothelial cell proliferation in acute synovitis...
  15. ncbi Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats
    K M Ellis
    Research Department, Novartis Institute for Biomedical Research, 4002 Basel, Switzerland
    Naunyn Schmiedebergs Arch Pharmacol 369:166-78. 2004
    ....
  16. ncbi Polymorphisms in the bradykinin B2 receptor gene and childhood asthma
    B Kusser
    Department of Clinical Chemistry and Pulmonary Disease, University Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Biol Chem 382:885-9. 2001
    ..Polymorphisms with a potential functional relevance have been described in the B2 bradykinin receptor gene. Study of these polymorphisms in 77 children with asthma and 73 controls revealed no association...
  17. ncbi Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen
    P Turner
    Department of Pharmacology, University College London, London, United Kingdom
    J Allergy Clin Immunol 107:105-13. 2001
    ....
  18. doi Downregulation of Bradykinin type 2 receptor expression in cardiac endothelial cells during senescence
    Laura Nurmi
    Wihuri Research Institute, University of Helsinki, Finland
    J Vasc Res 49:13-23. 2012
    ..Since endothelial aging is an independent risk factor for cardiovascular disease, we aimed to clarify the role of kinin receptors in age-related endothelial senescence...
  19. pmc Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis
    Jihong Dai
    Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 64:3574-82. 2012
    ..To examine whether activation of the plasma kallikrein-kinin system (KKS) mediates synovial recruitment of endothelial progenitor cells (EPCs) in arthritis...
  20. pmc Effects of kinin B(1) and B(2) receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats
    Stefânia Forner
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Br J Pharmacol 167:1737-52. 2012
    ..Kinin B(1) and B(2) receptors have been implicated in physiological and pathological conditions of the urinary bladder. However, their role in overactive urinary bladder (OAB) syndrome following spinal cord injury (SCI) remains elusive...
  21. doi The high glucose-induced stimulation of B1R and B2R expression via CB(1)R activation is involved in rat podocyte apoptosis
    Seul Ki Lim
    Bio therapy Human Resources Center, Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Republic of Korea
    Life Sci 91:895-906. 2012
    ..We examined renal kallikrein-kinin system (KKS) apoptosis and its related signaling pathway in rat podocytes. In addition, we studied the relationship of cannabinoid receptor 1 (CB(1)R) with high glucose and BK receptors...
  22. pmc Kinin-B2 receptor activity determines the differentiation fate of neural stem cells
    Cleber A Trujillo
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil 05508 000
    J Biol Chem 287:44046-61. 2012
    ..Here we describe novel functions for bradykinin and the kinin-B2 receptor (B2BkR) in differentiation of neural stem cells...
  23. pmc Bradykinin B2 receptor contributes to the exaggerated muscle mechanoreflex in rats with femoral artery occlusion
    Jian Lu
    Penn State Heart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Heart Circ Physiol 304:H1166-74. 2013
    ..Accordingly, results obtained from this study support our hypothesis that heightened kinin B2 receptor expression in the sensory nerves contributes to the exaggerated muscle mechanoreflex in rats with femoral artery occlusion...
  24. ncbi Hypotension in transgenic mice overexpressing human bradykinin B2 receptor
    D Z Wang
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425, USA
    Hypertension 29:488-93. 1997
    ..They also suggest that the B2 receptor-mediated signal transduction pathway plays a role in blood pressure regulation...
  25. doi Kinin-B2 receptor expression and activity during differentiation of embryonic rat neurospheres
    Antonio H Martins
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 73:361-8. 2008
    ..Functional kinin-B2 receptors and BK secretion indicate an autocrine loop during neurosphere differentiation to neurons, astrocytes, and oligodendrocytes, reflecting events occurring during early brain development...
  26. doi Expression of endogenous nuclear bradykinin B2 receptors mediating signaling in immediate early gene activation
    Martin Savard
    Department of Pharmacology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Cell Physiol 216:234-44. 2008
    ..Some evidence has suggested, however, the existence of an intracellular/nuclear B2R population. Whether these receptors are functional and contribute to BK signaling remains to be determined...
  27. ncbi Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma
    A M Akbary
    Hoecht Roussel Pharmaceuticals Inc, Somerville, NJ, USA
    Immunopharmacology 33:238-42. 1996
    ..No acute bronchodilator effect was found. In conclusion, Icatibant showed a profile expected for an anti-inflammatory asthma drug...
  28. pmc Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy
    M Majima
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Br J Pharmacol 121:723-30. 1997
    ..v.) and methysergide (3 mg kg-1, i.v.). 7. These results indicate that FR173657 is an orally active, promising anti-inflammatory agent for kinin-dependent inflammation...
  29. pmc Blockade of renal medullary bradykinin B2 receptors increases tubular sodium reabsorption in rats fed a normal-salt diet
    Sema Hayriye Sivritas
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 295:F811-7. 2008
    ..We conclude that in rats fed a normal-salt diet, kinins act tonically via medullary BKB(2) receptors to increase Na(+) excretion independent of changes in inner medullary blood flow...
  30. doi Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: how common is the AT1R/B2R heterodimer?
    Jakob L Hansen
    Laboratory for Molecular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Heart Centre, Copenhagen University Hospital, Copenhagen, Denmark
    J Biol Chem 284:1831-9. 2009
    ..2000) Nature 407, 94-98 ) that the angiotensin II type 1 receptor (AT1R) and the bradykinin B2 receptor (B2R) form constitutive heterodimers...
  31. doi The bradykinin B2 receptor mediates hypoxia/reoxygenation induced neuronal cell apoptosis through the ERK1/2 pathway
    Min Tang
    Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Neurosci Lett 450:40-4. 2009
    The bradykinin B2 receptor (B2R) mediates many physiological processes such as hypotension, inflammation and blood-vessel permeability. Hypoxia/reoxygenation (H/R) induces neuronal cell apoptosis...
  32. doi Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects
    Cornelia M Bertram
    Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, Australia
    J Leukoc Biol 85:544-52. 2009
    ..Importantly, anti-inflammatory corticosteroids down-regulated the expression of the kinin B(1)R...
  33. ncbi Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model
    Magdalena Bujalska
    Department of Pharmacodynamics, Medical University of Warsaw, Warsaw, Poland
    Neuro Endocrinol Lett 30:144-52. 2009
    ....
  34. pmc Receptor mediation and nociceptin inhibition of bradykinin-induced plasma extravasation in the knee joint of the rat
    Kumi Moriyama
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94143, USA
    Inflamm Res 58:873-80. 2009
    ..The aim was to investigate the signaling mechanisms and regulation of bradykinin (BK)-induced inflammation in rat knee joint...
  35. doi Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis
    Inka Liesmaa
    Wihuri Research Institute, Helsinki, Finland
    J Cell Physiol 221:359-66. 2009
    ..Our present results show that mild hypoxia triggers a temporal expression of functional BK-2Rs in human and rat endothelial cells and support a role for BK-2Rs in hypoxia-induced angiogenesis...
  36. doi Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans
    S W Woo
    Department of Pharmacological Research, National Institute of Toxicological Research, Seoul, Korea
    J Clin Pharm Ther 34:561-7. 2009
    ..It is documented that Asians are more liable to coughing than Europeans. The aim of this study was to investigate genetic polymorphism involved in ACE inhibitor-induced coughing...
  37. doi Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism
    Fiona A Russell
    Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada
    J Neurophysiol 103:155-63. 2010
    ..This PAR(4)-induced sensitization is TRPV1-independent but involves B(2) receptor activation, suggesting a role for kinins in this process...
  38. ncbi Splanchnic hyposensitivity to glypressin in a hemorrhage-transfused common bile duct-ligated rat model of portal hypertension: role of nitric oxide and bradykinin
    Chien Ting Chen
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taiwan
    Hepatogastroenterology 56:1261-7. 2009
    ..This study investigated the relative contribution of nitric oxide synthase isoforms and the role of bradykinin in the pathogenesis of splanchnic hyposensitivity in rats with cirrhosis induced by common bile duct-ligation (BDL)...
  39. doi Protease-activated receptor 2 and bradykinin-mediated vasodilation in the cerebral arteries of stroke-prone rats
    John S Smeda
    Division of Biomedical Sciences, Memorial University, St John s, Newfoundland, Canada
    Peptides 31:227-37. 2010
    ..Despite the presence of vascular injury, edema, inflammation and the loss of endothelium-dependent bradykinin vasodilation we found no evidence that PAR(2) expression or vascular function was altered in MCA after stroke...
  40. doi Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study
    Jérôme Côté
    Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Neuropeptides 44:177-85. 2010
    ..One approach for transporting drugs across the BBB involves the activation of bradykinin-B2 receptors (BK-B2R)...
  41. ncbi Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy
    Yan Tan
    Department of Medicine, Division of Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 293:F1026-35. 2007
    ..These findings provide the first evidence that targeted deletion of B2KR protects against the development of DN...
  42. ncbi Structure of the bradykinin B2 receptors' amino terminus
    S Abdalla
    Institute of Physiological Chemistry and Pathobiochemistry, University at Mainz, Germany
    Biochemistry 35:7514-9. 1996
    ..Antibodies raised against a peptide of the initial 27 amino acids of the human B2 receptor stained B2 receptors on intact cells. This finding excludes the existence of a signal sequence for this receptor...
  43. doi Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist
    Qingmin Chen
    Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Pancreas 39:1220-5. 2010
    ..Recently, we showed that spinal dynorphin was pronociceptive through direct or indirect BK receptor activation. Here, we explored the potential role of BK receptors in pain associated with persistent pancreatitis in rats...
  44. ncbi Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity
    P McIntyre
    Sandoz Institute for Medical Research, London, United Kingdom
    Mol Pharmacol 44:346-55. 1993
    ....
  45. doi Molecular effects of interleukin-1β on dorsal root ganglion neurons: prevention of ligand-induced internalization of the bradykinin 2 receptor and downregulation of G protein-coupled receptor kinase 2
    Gisela Segond von Banchet
    Jena University Hospital Friedrich Schiller University Jena, Institute of Physiology Ι, Teichgraben 8, D 07743 Jena, Germany
    Mol Cell Neurosci 46:262-71. 2011
    ....
  46. doi Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough
    Antonio Grilo
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz S N bNeocodex, Avda, Charles Darwin, Acc A Seville, Spain
    Pharmacogenet Genomics 21:10-7. 2011
    ..However, relatively little is known about the genetic susceptibility to ACEi-induced cough in hypertensive patients...
  47. pmc Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy
    Dongdong Sun
    Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, 710032, China
    Cardiovasc Diabetol 10:4. 2011
    ..The present study was to investigate the role of kinin B2 receptor-Akt-glycogen synthase kinase (GSK)-3β signalling pathway in mediating the protective effects of tanshinone IIA (TSN) on diabetic cardiomyopathy...
  48. ncbi Molecular cloning and sequence analysis of rat bradykinin B2 receptor gene
    D Z Wang
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425 2211
    Biochim Biophys Acta 1219:171-4. 1994
    ..A variant TATA box sequence, an IL-6 response element and a cAMP response element were identified in the 5' flanking region of the rat bradykinin B2 receptor gene...
  49. ncbi Molecular structure and expression of rat bradykinin B2 receptor gene. Evidence for alternative splicing
    J B Pesquero
    Department of Biophysics, Escola Paulista de Medicina, Sao Paulo, Brazil
    J Biol Chem 269:26920-5. 1994
    ....
  50. ncbi Effects of the bradykinin B2 receptor antagonist S 16118 (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) in different in vivo animal models of inflammation
    M Feletou
    Division de Pneumologie, Institut de Recherches Servier, Suresnes, France
    J Pharmacol Exp Ther 273:1078-84. 1995
    ..p. LPS (25 mg/kg) administration induced over 90% mortality in 96 hr. S 16118 (1 mg/kg x 4), given 30 min before LPS injection and 4, 8 and 24 hr after LPS injection, did not influence the mortality rate.(ABSTRACT TRUNCATED AT 250 WORDS)..
  51. pmc Comparative nasal effects of bradykinin, kallidin and [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers
    K Rajakulasingam
    Medicine 1, Centre Block, Southampton General Hospital
    J Physiol 437:577-87. 1991
    ..05). 3. These findings identify that the nasal effects of kinins are mediated through B2 receptors and the advent of B2 receptor antagonists will permit a further evaluation of the role of kinins in rhinitis...
  52. pmc Expression cloning of a rat B2 bradykinin receptor
    A E McEachern
    Howard Hughes Medical Institute, Stanford University, CA 94305
    Proc Natl Acad Sci U S A 88:7724-8. 1991
    ..As bradykinin is a key mediator of pain, knowledge of the primary structure of this receptor will allow a molecular understanding of the receptor and aid the design of antagonists for pain relief...
  53. ncbi Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy
    Frank Spillmann
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12220 Berlin, Germany
    Int Immunopharmacol 2:1823-32. 2002
    ..We have therefore investigated the bradykinin B1-receptor (B1R) and B2-receptor (B2R) mRNA expression in rat models of MI, LVH and diabetes mellitus (DM)...
  54. ncbi Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization
    Peter M Abadir
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Hypertension 48:316-22. 2006
    Angiotensin II type 2 (AT2R) or bradykinin B2 (B2R) receptor activation enhances NO production. Recently, we demonstrated enhancement of NO production when AT2R and B2R are simultaneously activated in vivo...
  55. ncbi Two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter
    Jessica Marks
    Department of Pediatrics, Section of Pediatric Nephrology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 278:34158-66. 2003
    ..The interplay of P1 and P2 may be important in the regulation of bradykinin B2 receptor gene expression in response to inflammatory stress and during development...
  56. ncbi Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy
    Brice Ongali
    Department of Physiology, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    J Comp Neurol 461:506-19. 2003
    ..An altered balance between B(1) and B(2) receptor populations may play a pivotal role in the onset and/or maintenance of epilepsy...
  57. ncbi Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells
    Yi Zhao
    Institute of Pharmacology, Christian Albrechts University of Kiel, Kiel, Germany
    J Neurochem 85:759-67. 2003
    ..The effects of angiotensin II on cell differentiation and cyclic GMP production were mediated via the AT2 receptor and further enhanced by bradykinin B2 receptor blockade...
  58. ncbi Kinin B2 receptor localization and expression in the hypothalamo-pituitary-adrenal axis of spontaneously hypertensive rats
    Fatimunnisa Qadri
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic of Lübeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Int Immunopharmacol 3:285-92. 2003
    ..Furthermore, compared to normotensive Wistar-Kyoto (WKY) rats, SHR show hypersensitivity to bradykinin (BK)-induced pressor responses which may be caused by an upregulation of B(2) receptor expression in the brain...
  59. ncbi Down-regulation of bradykinin B2-receptor mRNA in the heart in pressure-overload cardiac hypertrophy in the rat
    Katsutoshi Yayama
    Department of Pharmacology, Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Ikawadani cho, Nishi ku, Kobe 651 2180, Japan
    Biochem Pharmacol 65:1017-25. 2003
    ....
  60. ncbi Tissue kallikrein and bradykinin B2 receptors in the reproductive tract of the male rat
    T K Monsees
    Centre of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
    Andrologia 35:24-31. 2003
    ..tKKS) within the reproductive organs of the male rat was investigated by analysing bradykinin subtype 2 receptor (B2R) gene expression and cellular distribution of B2R protein and the kinin-liberating protease tissue kallikrein (tK)...
  61. ncbi Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough
    S Mukae
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Hum Hypertens 16:857-63. 2002
    ....
  62. ncbi Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough
    S Mukae
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Hypertension 36:127-31. 2000
    ..A genetic variant of the bradykinin receptor is involved in the elicitation of ACE inhibitor-related cough. It may be possible to predict the side effects of ACE inhibitors in advance...
  63. ncbi Expression and location of the bradykinin B2 receptor in rat testis
    Thomas K Monsees
    Center for Dermatology and Andrology, Justus Liebig University, D 35385 Giessen, Germany
    Biol Reprod 67:1832-9. 2002
    ..The results point to a possible function of the tissue kallikrein-kinin system in the local regulation of spermatogenesis...
  64. ncbi Transcriptional regulation of the rat bradykinin B2 receptor gene: identification of a silencer element
    Heloisa A Baptista
    Center for Development of Experimental Models in Medicine and Biology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Mol Pharmacol 62:1344-55. 2002
    ..In summary, these data highlight the cell-specific regulation of the BKB2 receptor and the importance of a silencer element present in the regulatory region of the gene...
  65. ncbi A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation
    Johan Duchene
    INSERM U388, Institut Louis Bugnard, Institute Fédératif de Recherche 31, Centre Hospitalier Universitaire Rangueil, 1 avenue J Poulhes, 31403 Toulouse Cedex, France
    J Biol Chem 277:40375-83. 2002
    ..These observations demonstrate that bradykinin inhibits cell proliferation by a novel mechanism involving a direct protein-protein interaction between a GPCR (the B2 receptor) and SHP-2...
  66. ncbi B2 receptor activation reduces Erk1 and Erk2 phosphorylation induced by insulin-like growth factor-1, platelet-derived growth factor-BB, and high glucose in rat isolated glomeruli
    Eric Cellier
    INSERM U388, IFR 31, Institut Louis Bugnard, CHU Rangueil, Toulouse, France
    Can J Physiol Pharmacol 80:341-5. 2002
    ..of the mitogen-activated protein kinases Erk1 and Erk2 by bradykinin (BK), an agonist of the kinin B2 receptor (B2R). In contrast, other reports showed an inhibitory modulation of mitogenesis by BK...
  67. ncbi Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats
    F Qadri
    Institute for Experimental and Clinical Pharmacology and Toxicology, University Clinic of Lübeck, Germany
    Can J Physiol Pharmacol 80:258-63. 2002
    ....
  68. pmc Pharmacologic and autoradiographic evidence for an up-regulation of kinin B(2) receptors in the spinal cord of spontaneously hypertensive rats
    Frank Cloutier
    Department of Physiology, Faculty of Medicine, Universite de Montreal C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada, H3C 3J7
    Br J Pharmacol 135:1641-54. 2002
    ....
  69. ncbi Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus
    Y J Lee
    Department of Clinical Research, Ping Tung Christian Hospital, Ping Tung, Taiwan, Republic of China
    Metabolism 50:1346-50. 2001
    ..In conclusion, our results indicate that Chinese diabetic female subjects are susceptible to ACEI-related cough, and this susceptibility may be genetically predetermined...
  70. ncbi Role of bradykinin B2 receptors in the formation of vasogenic brain edema in rats
    N Plesnila
    Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Neurotrauma 18:1049-58. 2001
    ..Our findings further clarify the role of bradykinin in the pathophysiology of brain edema formation and confirm the therapeutic potency of bradykinin B2 receptor inhibition...
  71. ncbi Mechanisms of angiotensin II-induced expression of B2 kinin receptors
    Yan Tan
    Dept of Medicine, Endocrinology Diabetes Medical Genetics, Medical Univ of South Carolina, 114 Doughty St, PO Box 250776, Charleston, SC 29425, USA
    Am J Physiol Heart Circ Physiol 286:H926-32. 2004
    ..These findings demonstrate that ANG II regulates expression of B2KR in VSMC and provide a rationale for studying the interaction between ANG II and bradykinin in the pathogenesis of vascular dysfunction...
  72. ncbi Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells
    V Soskic
    Institute of Molecular Biotechnology e V, 07745 Jena, Germany
    J Biol Chem 274:8539-45. 1999
    ....
  73. ncbi Inhibition of angiotensin-converting enzyme reduces rat liver reperfusion injury via bradykinin-2-receptor
    Hendrik Freise
    Department of General Surgery, Surgical Research, University Hospital Muenster, Muenster, Germany
    J Surg Res 134:231-7. 2006
    ..On the other hand, B-2-inhibition has been shown to reduce liver reperfusion injury. This study was designed to investigate the role of Bradykinin in hepatic reperfusion injury...
  74. ncbi Role of bradykinin B1 and B2 receptors in normal blood pressure regulation
    Arvi Duka
    Hypertension and Atherosclerosis Section, Department of Medicine, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 291:E268-74. 2006
    With inhibition or absence of the bradykinin B2 receptor (B2R), B1R is upregulated and assumes some of the hemodynamic properties of B2R, indicating that both participate in the maintenance of normal vasoregulation or to development of ..
  75. ncbi Autoradiographic distribution and alterations of kinin B(2) receptors in the brain and spinal cord of streptozotocin-diabetic rats
    Maria Martha Campos
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Synapse 58:184-92. 2005
    ..This contrasts with the early induction and over-expression of B(1) receptors reported in the brain and spinal cord of STZ-diabetic rats...
  76. ncbi Treatment of severe pulmonary hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy
    Laimute Taraseviciene-Stewart
    Pulmonary Hypertension Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Peptides 26:1292-300. 2005
    ....
  77. pmc Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia
    S Poole
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Br J Pharmacol 126:649-56. 1999
    ....
  78. pmc Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium
    Bikramjit Chopra
    A1207 Scaife Hall, Department of Medicine Renal Division, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Physiol 562:859-71. 2005
    ..Our findings indicate that the bradykinin 2 receptor (B2R) but not the bradykinin 1 receptor (B1R) is expressed in control bladder urothelium...
  79. ncbi Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy
    Koh Ichi Yuhki
    Department of Pharmacology, Asahikawa Medical College, Japan
    J Pharmacol Exp Ther 311:1218-24. 2004
    ..These results demonstrate participation of EP2 and EP3 along with IP in pleural exudate formation but not in leukocyte migration in carrageenin-induced mouse pleurisy...
  80. pmc Bradykinin down-regulates LPS-induced eosinophil accumulation in the pleural cavity of mice through type 2-kinin receptor activation: a role for prostaglandins
    A R Silva
    Departamento de Fisiologia e Farmacodinamica, IOC, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    Br J Pharmacol 127:569-75. 1999
    ..25 nmol cavity(-1)) injected mice. 6. In conclusion, endogenously generated bradykinin seems to modulate, through activation of B2 receptors, eosinphil accumulation induced by LPS via a mechanism dependent on prostanoid synthesis...
  81. ncbi Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis
    I M Sainz
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    FASEB J 18:887-9. 2004
    ..These effects are mediated by bradykinin-1 (B1R) and-2 (B2R) receptors...
  82. ncbi Cyclooxygenase inhibitors attenuate bradykinin-induced vasoconstriction in septic isolated rat lungs
    L G Fischer
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Westfalische Wilhelms Universitat Munster, Germany
    Anesth Analg 90:625-31. 2000
    ..This study suggests that nonselective COX inhibition, and possibly inhibition of the inducible isoform COX-2, may attenuate sepsis-induced, receptor-mediated vasoconstriction in rats...
  83. ncbi Therapeutical efficacy of a novel non-peptide bradykinin B2 receptor antagonist on brain edema formation and ischemic tissue damage in focal cerebral ischemia
    S Zausinger
    Department of Neurosurgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Acta Neurochir Suppl 86:205-7. 2003
    ..We currently studied neuroprotective properties of a bradykinin B2 receptor antagonist (LF16-0687 Ms) in transitory focal cerebral ischemia to assess infarct formation and the development of brain edema...
  84. ncbi Direct protein-protein interaction between PLCgamma1 and the bradykinin B2 receptor--importance of growth conditions
    Johan Duchene
    INSERM U388, IFR 31, Hopital Rangueil, TSA 50032, 31059 Toulouse Cedex 9, France
    Biochem Biophys Res Commun 326:894-900. 2005
    ..Mutation of the key ITIM residue abolished this interaction with and activation of PLCgamma1. Finally we also identified bradykinin-induced PLCgamma1 recruitment and activation in primary culture renal mesangial cells...
  85. ncbi B2 bradykinin receptor mediates the stimulatory effect of bradykinin on rat germ cell proliferation in vitro
    N N Atanassova
    Institute of Experimental Morphology and Anthropology, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Andrologia 35:13-6. 2003
    ....
  86. ncbi Age-related changes of bradykinin B1 and B2 receptors in rat heart
    Ekaterina Kintsurashvili
    Hypertension and Atherosclerosis Section, Boston Univ School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Physiol Heart Circ Physiol 289:H202-5. 2005
    ..This study aims to investigate whether changes in B1R and B2R gene and protein expression in rat heart are associated with the age-related alterations of cardiac structure and ..
  87. ncbi Interleukin-1beta enhanced action of kinins on extracellular matrix of spontaneous hypertensive rat cardiac fibroblasts
    Chiharu Imai
    Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    Clin Exp Hypertens 27:59-69. 2005
    ....
  88. doi Enalapril treatment corrects the reduced response to bradykinin in diabetes increasing the B2 protein expression
    Viviani Milan Ferreira Rastelli
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Cidade Universitaria, Sao Paulo, Brazil
    Peptides 29:404-11. 2008
    ..From our data, we conclude that in diabetes enalapril corrects the impaired BK response probably by increasing the expression of B2 receptors. The lack of potentiation of BK by Ang-(1-7) is not corrected by this agent...
  89. doi Role of kinin B1 and B2 receptors in a rat model of neuropathic pain
    M Petcu
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Int Immunopharmacol 8:188-96. 2008
    ..This study measured the densities of B1R and B2R binding sites in the spinal cord and dorsal root ganglia (DRG) by quantitative autoradiography, and evaluated the ..
  90. ncbi Expression of bradykinin receptors in the left ventricles of rats with pressure overload hypertrophy and heart failure
    Antti Kuoppala
    Wihuri Research Institute, Helsinki, Finland
    J Hypertens 21:1729-36. 2003
    ..Thus, the presence of a cardioprotective BK-2R signaling system may be critical in the prevention of pressure overload-induced heart failure...