Cacna1c

Summary

Gene Symbol: Cacna1c
Description: calcium voltage-gated channel subunit alpha1 C
Alias: RATIVS302, voltage-dependent L-type calcium channel subunit alpha-1C, L-type calcium channel alpha-1 subunit, RBC, brain class C, calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, calcium channel, voltage-dependent, L type, alpha 1C subunit, calcium channel, voltage-dependent, alpha 1C subunit, voltage-gated calcium channel subunit alpha Cav1.2
Species: rat

Top Publications

  1. ncbi L-type voltage-gated calcium channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia
    Yong Liu
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Jiangsu 221002, Xuzhou, China
    Brain Res 972:142-8. 2003
  2. ncbi Spontaneous regenerative activity in mammalian retinal bipolar cells: roles of multiple subtypes of voltage-dependent Ca2+ channels
    Yu Ping Ma
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Vis Neurosci 20:131-9. 2003
  3. ncbi Calbindin-D28k decreases L-type calcium channel activity and modulates intracellular calcium homeostasis in response to K+ depolarization in a rat beta cell line RINr1046-38
    David Lee
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    Cell Calcium 39:475-485. 2006
  4. pmc Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain
    Joanne T Hulme
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, 98195 7280, USA
    J Physiol 576:87-102. 2006
  5. pmc The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscle
    Dusan M Jeftinija
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Muscle Nerve 36:482-90. 2007
  6. pmc Spatial association of the Cav1.2 calcium channel with α5β1-integrin
    Jun Tzu Chao
    Dept of Medical Pharmacology and Physiology, M451 Med Sci Bldg, Univ of Missouri, Columbia, 1 Hospital Dr, Columbia, MO 65211, USA
    Am J Physiol Cell Physiol 300:C477-89. 2011
  7. pmc A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons
    Katherine E Brandao
    Program in Neuroscience, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA
    J Comp Neurol 520:81-99. 2012
  8. ncbi Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel alpha 1 subunit
    J W Hell
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 268:19451-7. 1993
  9. ncbi Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade
    Michelle Day
    Department of Physiology Northwestern University Institute for Neuroscience, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurophysiol 87:2490-504. 2002
  10. ncbi Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation
    Hannelore Haase
    Max Delbrück Center for Molecular Medicine MDC, D 13092 Berlin, Germany
    FASEB J 19:1969-77. 2005

Scientific Experts

Detail Information

Publications106 found, 100 shown here

  1. ncbi L-type voltage-gated calcium channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia
    Yong Liu
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Jiangsu 221002, Xuzhou, China
    Brain Res 972:142-8. 2003
    ..Src and Pyk2 interacting with NR2A might also be involved in this regulation of the tyrosine phosphorylation of NR2A induced by I/R...
  2. ncbi Spontaneous regenerative activity in mammalian retinal bipolar cells: roles of multiple subtypes of voltage-dependent Ca2+ channels
    Yu Ping Ma
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Vis Neurosci 20:131-9. 2003
    ..However, T-type Ca2+ channels appear to be essential for the initiation of the spontaneous activity in mammalian bipolar cells...
  3. ncbi Calbindin-D28k decreases L-type calcium channel activity and modulates intracellular calcium homeostasis in response to K+ depolarization in a rat beta cell line RINr1046-38
    David Lee
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    Cell Calcium 39:475-485. 2006
    ..We thus conclude that calbindin-D(28k) can regulate calcium influx via L-type calcium channels. Our findings suggest a role for calbindin-D(28k) in the beta cell in modulating Ca(2+) influx via L-type voltage-dependent calcium channels...
  4. pmc Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain
    Joanne T Hulme
    Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, 98195 7280, USA
    J Physiol 576:87-102. 2006
    ..2 channel function...
  5. pmc The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscle
    Dusan M Jeftinija
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Muscle Nerve 36:482-90. 2007
    ..2 and type IIa-positive fibers. Taken together, these data suggest that the Ca(V) 1.2 Ca(2+) channel is expressed in adult skeletal muscle in a fiber type-specific manner, which may help to maintain oxidative muscle phenotype...
  6. pmc Spatial association of the Cav1.2 calcium channel with α5β1-integrin
    Jun Tzu Chao
    Dept of Medical Pharmacology and Physiology, M451 Med Sci Bldg, Univ of Missouri, Columbia, 1 Hospital Dr, Columbia, MO 65211, USA
    Am J Physiol Cell Physiol 300:C477-89. 2011
    ..These findings provide new evidence for how interactions between α(5)β(1)-integrin and FN can modulate Ca(L) entry and consequently alter the physiological function of multiple types of excitable cells...
  7. pmc A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons
    Katherine E Brandao
    Program in Neuroscience, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA
    J Comp Neurol 520:81-99. 2012
    ..Thus AKAP150 is expressed in small, nociceptive DRG neurons, where it is targeted to membrane regions and where it may play a role in the modulation of ion channel phosphorylation states required for hyperalgesia...
  8. ncbi Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel alpha 1 subunit
    J W Hell
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 268:19451-7. 1993
    ....
  9. ncbi Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade
    Michelle Day
    Department of Physiology Northwestern University Institute for Neuroscience, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurophysiol 87:2490-504. 2002
    ..2 L-type Ca(2+) currents. This modulation and its blockade by atypical neuroleptics could have wide-ranging effects on synaptic integration and long-term gene expression in deep-layer prefrontal pyramidal neurons...
  10. ncbi Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation
    Hannelore Haase
    Max Delbrück Center for Molecular Medicine MDC, D 13092 Berlin, Germany
    FASEB J 19:1969-77. 2005
    ..This genetic ahnak variant might cause individual differences in I(CaL) regulation upon physiological challenges or therapeutic interventions...
  11. ncbi Caldendrin, a neuron-specific modulator of Cav/1.2 (L-type) Ca2+ channels
    Alyssa L Tippens
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:8464-73. 2007
    ..Our findings reveal functional diversity within related Ca2+-binding proteins, which may enhance the specificity of Ca2+ signaling by Cav1.2 channels in different cellular contexts...
  12. pmc beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway
    Rachele Lipsky
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 283:17221-6. 2008
    ....
  13. doi CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells
    Marloes Dekker Nitert
    Molecular Metabolism Islet Cell Exocytosis, Department of Clinical Science, Clinical Research Center, SE 205 02 Malmo, Sweden Lund University Diabetes Center, Malmo, Sweden
    J Mol Endocrinol 41:1-11. 2008
    ..2 expression in transfected cells since knock-down of Ca(V)1.3 did not affect glucose-stimulated insulin secretion. In summary, our results suggest that Ca(V)1.2 is critical for insulin secretion in INS-1 832/13 cells...
  14. pmc Sequence differences in the IQ motifs of CaV1.1 and CaV1.2 strongly impact calmodulin binding and calcium-dependent inactivation
    Joshua Ohrtman
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Biol Chem 283:29301-11. 2008
    ..Thus, our results reveal that a conserved difference between the IQ motifs of Ca(V)1.2 and Ca(V)1.1 has a profound effect on both CaM binding and calcium-dependent inactivation...
  15. ncbi Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS
    T P Snutch
    Biotechnology Laboratory, Department of Neuroscience, University of British Columbia, Vancouver, Canada
    Neuron 7:45-57. 1991
    ..Two rat brain Ca2+ channel alpha 1 subunits (rbC-I and rbC-II) have been isolated by molecular cloning and shown to be highly related (95%) to the cardiac ..
  16. pmc Increased phosphorylation of the neuronal L-type Ca(2+) channel Ca(v)1.2 during aging
    Monika A Davare
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706 1532, USA
    Proc Natl Acad Sci U S A 100:16018-23. 2003
    ..2 by cAMP-dependent protein kinase strongly enhances its activity. Therefore, increased Cav1.2 phosphorylation may account for a substantial portion of the age-related rise in neuronal Ca2+ influx and its neuropathological consequences...
  17. ncbi The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology L1 03, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Endocr Rev 27:621-76. 2006
    ..This review summarizes current knowledge of CaV channels in beta-cell physiology and pathophysiology...
  18. pmc Silencing of Cav1.2 gene in neonatal cardiomyocytes by lentiviral delivered shRNA
    Eddy Karnabi
    VA New York Harbor Healthcare System, New York, NY, USA
    Biochem Biophys Res Commun 384:409-14. 2009
    ..This novel approach allows for the assessments of the roles of alpha1C and alpha1D Ca channels in native myocytes and could be used to examine their roles in physiological and pathological settings...
  19. doi The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels
    Christophe Altier
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Neurosci 14:173-80. 2011
    ..Thus, Cavββ regulates the ubiquitination and stability of the calcium channel complex...
  20. pmc The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels
    Brett A Simms
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    Mol Brain 5:9. 2012
    ..2 (A39V) has been shown to elicit disease a phenotype because of a loss of surface trafficking of the channel. This lack of cell membrane expression could not be rescued by the trafficking chaperone Cavβ...
  21. ncbi Essential Ca(V)beta modulatory properties are AID-independent
    Janet M Maltez
    Department of Pharmacology, Columbia University, New York, New York 10032, USA
    Nat Struct Mol Biol 12:372-7. 2005
    ....
  22. pmc Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart
    R J Diebold
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267 0575
    Proc Natl Acad Sci U S A 89:1497-501. 1992
    ..The results demonstrate the existence of an important developmentally regulated switch mediated by alternatively spliced exons in cardiac tissue at a time when major changes in excitation occur...
  23. pmc Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes
    D R Scriven
    Department of Physiology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Biophys J 79:2682-91. 2000
    ..We conclude that if either the slip mode conductance of the Na(+) channel or the reverse mode of the Na(+)/Ca(2+) exchanger are to contribute to the contractile force, the fuzzy space must extend outside of the dyad...
  24. ncbi Skeletal and cardiac ryanodine receptors bind to the Ca(2+)-sensor region of dihydropyridine receptor alpha(1C) subunit
    J Mouton
    Laboratoire de Neurobiologie Cellulaire, CNRS FRE 2180, Strasbourg, France
    FEBS Lett 505:441-4. 2001
    ..The interaction is restricted to the CB and IQ motifs involved in the calmodulin-mediated Ca(2+)-dependent inactivation of the DHPR, suggesting functional interactions between the two channels...
  25. ncbi A new promoter for alpha1C subunit of human L-type cardiac calcium channel Ca(V)1.2
    Bosong Dai
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555 0641, USA
    Biochem Biophys Res Commun 296:429-33. 2002
    ..The putative promoter exhibits 69% homology to its rat counterpart and displays functional promoter activity when transfected into heart cells in culture in luciferase-expressing constructs...
  26. ncbi Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels
    Hong Zhou
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 24:4698-708. 2004
    ..2 with these same voltage protocols. Our findings reveal how Ca2+-binding proteins, such as CaM and CaBP1, differentially adjust Ca2+ influx through Ca(v)1.2 channels, which may specify diverse modes of Ca2+ signaling in neurons...
  27. pmc A novel Ca(V)1.2 N terminus expressed in smooth muscle cells of resistance size arteries modifies channel regulation by auxiliary subunits
    Xiaoyang Cheng
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 282:29211-21. 2007
    ..contain a novel, cysteine rich N terminus that is derived from exon 1 (termed "exon 1c"), which is located within CACNA1C, the Ca(V)1.2 gene...
  28. pmc Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel
    Andrés D Maturana
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Osaka 567 0047, Japan
    Cardiovasc Res 78:458-65. 2008
    ....
  29. pmc Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel
    Samvit Tandan
    Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390 8573, USA
    Circ Res 105:51-60. 2009
    ..Furthermore, they demonstrate that calcineurin induces robust increases in I(Ca,L) and highlight calcineurin as a key modulator of pathological electrical remodeling in cardiac hypertrophy...
  30. pmc Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture
    Conor P Walsh
    Cardiovascular Medicine, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    J Biol Chem 284:22310-21. 2009
    ..2 binding and for the first time identifies the size and organization of the alpha2delta polypeptides...
  31. pmc Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy
    Susan D Kraner
    Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1384-91. 2011
    ..There was also selective degradation of myosin heavy chain relative to actin in CIM muscle. Taken together, our findings suggest that increased Ca(2+) release from the sarcoplasmic reticulum may contribute to pathology in CIM...
  32. doi Splice variant specific modulation of CaV1.2 calcium channel by galectin-1 regulates arterial constriction
    Juejin Wang
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Circ Res 109:1250-8. 2011
    ..We have identified Gal-1 multiple times in yeast 2-hybrid assays using the Ca(V)1.2 I-II loop as bait...
  33. pmc Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development
    Rasha R Abd El-Rahman
    Hotchkiss Brain and Libin Cardiovascular Research Institute and Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada
    Am J Physiol Heart Circ Physiol 304:H58-71. 2013
    ..Both conductances contribute to myogenic tone, although their overall contribution is unequal...
  34. doi Distribution of voltage-dependent and intracellular Ca2+ channels in submucosal neurons from rat distal colon
    Matthias Rehn
    Institute for Veterinary Physiology and Biochemistry, Justus Liebig University, Giessen, Germany
    Cell Tissue Res 353:355-66. 2013
    ..Thus, rat submucosal neurons are equipped with various types of high-voltage activated Ca(v) channels and with IP3 receptors for intracellular Ca2+ signaling...
  35. doi Reduced DHPRα1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis
    Guang Yu Jiao
    Respiratory Department and Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang, Postal Code, 110004, People s Republic of China
    Muscle Nerve 48:745-51. 2013
    ..However, their expression in diaphragm during sepsis have not been explored...
  36. doi A novel calmodulin site in the Cav1.2 N-terminus regulates calcium-dependent inactivation
    Brett A Simms
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Dr NW, Calgary, T2N 4N1, Canada
    Pflugers Arch 466:1793-803. 2014
    ..Thus, our data indicate that calcium regulation of Cav1.2 channels is more complex than previously thought, and involves more than one region within the channel's N-terminal domain. ..
  37. pmc Uncoupling of Cav1.2 from Ca(2+)-induced Ca(2+) release and SK channel regulation in pancreatic β-cells
    Yuchen Wang
    Purdue University Life Sciences Graduate Program R E J, E P S P, A M L and Department of Medicinal Chemistry and Molecular Pharmacology Y W, M L G, A E S, I M S, G H H, Purdue University, West Lafayette, Indiana 47907 2091
    Mol Endocrinol 28:458-76. 2014
    ..2/II-III loop-expressing cells. We propose the II-III loop of Cav1.2 as a key molecular determinant that couples the channel to Ca(2+)-induced Ca(2+) release and activation of SK channels in pancreatic β-cells. ..
  38. doi Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress
    Li Li Ji
    Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P R China
    Mol Med Rep 9:1165-70. 2014
    ..These results indicated that VDR may be involved in the pathogenesis of SPS rats, thereby providing an alternative preparation to search for optimal therapeutic strategies for PTSD...
  39. pmc Alcohol Withdrawal-Induced Seizure Susceptibility is Associated with an Upregulation of CaV1.3 Channels in the Rat Inferior Colliculus
    PROSPER N'GOUEMO
    Georgetown University Medical Center, Department of Pediatrics, Washington DC Drs N Gouemo and Akinfiesoye Howard University College of Medicine, Department of Physiology and Biophysics, Washington DC Dr Allard Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD Dr Lovinger
    Int J Neuropsychopharmacol 18:pyu123. 2015
    ..However, the molecular correlate of this increased CaV1 current is currently unknown...
  40. pmc Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia
    Ran Li
    Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, 10 You An Men, Beijing, 100069, People s Republic of China
    Cell Stress Chaperones 20:507-16. 2015
    ..2 gene, but not that of the Cav1.3 gene. These data indicated that Cav1.2 might be regulated by HIF-1α as one of its downstream target genes and involved in regulation of PC12 cells death under hypoxia. ..
  41. doi Ca(V)1.2 and Ca(V)1.3 L-type calcium channels regulate the resting membrane potential but not the expression of calcium transporters in differentiated PC12 cells
    Lucia Lichvárová
    Institute of Molecular Physiology and Genetics, Centre of Excellence for Cardiovascular Research, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Gen Physiol Biophys 34:157-65. 2015
    ..of LTCC subtypes was downregulated by transfection of NGF-differentiated PC12 cells with siRNA for either CACNA1C or CACNA1D gene. Efficiency of gene silencing was verified by RT-PCR and by functional essay...
  42. doi Different effects of lysophosphatidic acid on L-type calcium current in neonatal rat ventricular myocytes with and without H2O2 treatment
    Renren Sun
    Department of Physiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China
    Prostaglandins Other Lipid Mediat 118:1-10. 2015
    ..In conclusion, LPA increases the I(Ca-L) in normal ventricular myocytes by increasing the single-channel open probability of L-type calcium channels, and LPA decreases I(Ca-L) in H2O2-treated cardiomyocytes via the CaN-NFAT pathway...
  43. pmc Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability
    Zully Pedrozo
    From Division of Cardiology, Department of Internal Medicine Z P, A C, P K B, C R M, N J, X L, B A R, T G G, S L, J A H and Department of Molecular Biology B A R, J A H, UT Southwestern Medical Center, Dallas, TX Advanced Center for Chronic Diseases and Centro de Estudios Moleculares de la Célula, Facultad de Medicina and Facultad de Ciencias Químicas y Farmacéuticas, Santiago, Chile Z P, A C F, C F, S L Instituto de Ciencias Biomédicas, Facultad de Medicina Z P, S L and Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología A C, Universidad de Chile, Santiago and Departments of Cellular and Molecular Physiology M J C, Internal Medicine S S, and Genetics S S, Yale University School of Medicine, New Haven, CT
    Circulation 131:2131-42. 2015
    ..Polycystin-1 (PC-1) is a G protein-coupled receptor-like protein that functions as a mechanosensor in a variety of cell types and is present in cardiomyocytes...
  44. doi Alterations of Ca(v)1.2 and 5-hydroxytryptamine in rat hearts after positional asphyxia
    X F Li
    a Library of Dali University, Dali, Yunnan Province, China
    Biotech Histochem 90:615-9. 2015
    ..Our findings indicate that Ca(v)1.2 and 5-HT alterations could cause abnormal cardiac function, and the proteins investigated here may be useful for investigating the mechanisms underlying positional asphyxia. ..
  45. pmc Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation
    Meng Hua Zhou
    From the Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030
    J Biol Chem 290:30616-23. 2015
    ..S-Nitrosylation mediates the feedback regulation of N-type channels by NO...
  46. ncbi Thiamine Deficiency Increases Ca2+ Current and CaV1.2 L-type Ca2+ Channel Levels in Cerebellum Granular Neurons
    Daniel C Moreira-Lobo
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, 6627, Bloco K4, Sala 167, Belo Horizonte, MG, CEP 31270 901, Brazil
    Cell Mol Neurobiol . 2016
    ..2 expression. These results indicate a link between alterations in glycolytic metabolism and changes to Ca2+ dynamics, two factors that have been implicated in neurodegeneration...
  47. pmc Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations
    Igor Splawski
    Howard Hughes Medical Institute, Department of Cardiology, and Genomics Program and Division of Genetics, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:8089-96; discussion 8086-8. 2005
    ..These data indicate that gain-of-function mutations of CaV1.2 exons 8 and 8A cause distinct forms of TS...
  48. pmc Voltage-gated calcium channels
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    Cold Spring Harb Perspect Biol 3:a003947. 2011
    ..This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties...
  49. doi Mechanism of osthole inhibition of vascular Ca(v)1.2 current
    Fabio Fusi
    Dipartimento di Neuroscienze, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Eur J Pharmacol 680:22-7. 2012
    ..This mechanism may account for the systolic blood pressure reduction induced by the drug in animal models of hypertension and points to osthole as a lead for the development of novel antihypertensive agents...
  50. doi Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain
    Chia Yi Huang
    Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan 112
    J Comp Neurol 520:3650-72. 2012
    ..These data suggest that Kv3.4 and Cav1.2, two high-voltage-activated ion channels, may act together to control Ca²⁺ -dependent electrical activity of pioneer axons and play important roles during axon pathfinding...
  51. pmc Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid
    Aihua Qian
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Mol Pain 9:15. 2013
    ..We investigated the molecular mechanisms and the role for voltage gated calcium channel (VGCC) in the pathogenesis in a rat model of 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced visceral inflammatory hypersensitivity...
  52. pmc Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels and CaMKII functions regulating protein turnover in the hippocampus
    Weber Cláudio da Silva
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul, RS90610 000 Porto Alegre, Brazil
    Proc Natl Acad Sci U S A 110:6566-70. 2013
    ....
  53. pmc Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone
    E L Barry
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755 3835, USA
    Proc Natl Acad Sci U S A 92:10914-8. 1995
    ..The present results provide evidence for the expression of three distinct calcium channel alpha 1-subunit isoforms in an osteoblast-like cell line. We conclude that the alpha 1D isoform is selectively activated by parathyroid hormone...
  54. ncbi Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Czech Republic
    J Am Soc Nephrol 11:1261-5. 2000
    ....
  55. ncbi Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin
    T Coppola
    Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, 1005 Lausanne, Switzerland
    J Biol Chem 276:32756-62. 2001
    ..We propose that the Rab3 effector RIM is a scaffold protein that participates through its multiple binding partners in the docking and fusion of secretory vesicles at the release sites...
  56. ncbi Cloning of a functional splice variant of L-type calcium channel beta 2 subunit from rat heart
    Y Yamada
    Department of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Biol Chem 276:47163-70. 2001
    ..Taken together, these observations suggest that the beta(2c) subunit is a functional beta(2) subunit expressed in heart and that the short N-terminal region plays a major role in modifying inactivation kinetics...
  57. ncbi Norepinephrine regulates the in vivo expression of the L-type calcium channel
    Kish L Golden
    Department of Physiology and Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Mol Cell Biochem 236:107-14. 2002
    ..01). We conclude norepinephrine treatment alters DHPr mRNA and protein levels, and augments excitation-contraction coupling, and thus may be important for modulating cardiac calcium homeostasis in vivo...
  58. ncbi A 27 bp cis-acting sequence is essential for L-type calcium channel alpha(1C) subunit expression in vascular smooth muscle cells
    Q Ivy Fan
    Program in Molecular and Cellular Cardiology, Department of Internal Medicine, Wayne State University School of Medicine, 421 E Canfield Avenue, Detroit, MI 48201, USA
    Biochim Biophys Acta 1577:401-11. 2002
    ..We conclude that there is a 27 bp region in the promoter of the Ca(v)1.2 gene to which nuclear proteins from VSMC bind and strongly regulate the basal promoter activity...
  59. ncbi Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes
    Isabelle Latour
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada
    Glia 41:347-53. 2003
    ..Overall, our data indicate that astrocytes express multiple types of voltage-gated Ca(2+) channels, hinting at a complex regulation of Ca(2+) homeostasis in glial cells...
  60. ncbi Voltage-gated calcium channels in adult rat inferior colliculus neurons
    P N'GOUEMO
    Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
    Neuroscience 120:815-26. 2003
    ..We conclude that IC neurons express functionally all members of HVA Ca(2+) channels, but only a subset of these neurons appear to have developed functional LVA channels...
  61. pmc Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 100:13093-8. 2003
    ....
  62. ncbi Leukemia inhibitory factor activates cardiac L-Type Ca2+ channels via phosphorylation of serine 1829 in the rabbit Cav1.2 subunit
    Eiichi Takahashi
    Institute for Advanced Cardiac Therapeutics, Shinanomachi Research Park, Keio University School of Medicine, Tokyo, Japan
    Circ Res 94:1242-8. 2004
    ..2 subunit via the actions of extracellular signal-regulated kinase and that this phosphorylation increases I(CaL) in cardiomyocytes...
  63. ncbi The L-type calcium channel alpha 1C subunit gene undergoes extensive, uncoordinated alternative splicing
    Q Ivy Fan
    Molecular and Cellular Cardiology, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Mol Cell Biochem 269:153-63. 2005
    ..Alternative splicing is not tissue-specific in most regions...
  64. pmc Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors
    David R L Scriven
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Biophys J 89:1893-901. 2005
    ..Because of their location, the signaling molecules contained within these caveolae may have preferred access to the neighboring nondyadic ryanodine receptors...
  65. ncbi CSN5/Jab1 inhibits cardiac L-type Ca2+ channel activity through protein-protein interactions
    Kazutoshi Kameda
    Department of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Mol Cell Cardiol 40:562-9. 2006
    ..These data indicate that CSN5 is a protein that plays a newly defined functional role in association with the cardiac L-type Ca(2+) channel...
  66. ncbi Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation
    Duane D Hall
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Biochemistry 45:3448-59. 2006
    ..2 is required for effective reversal of PKA-mediated channel phosphorylation. Accordingly, PKA as well as PP2A are constitutively associated with Ca(v)1.2 for its proper regulation by phosphorylation and dephosphorylation of serine 1928...
  67. ncbi Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts
    Seiji Hatano
    The Cardiovascular Institute, Tokyo, Japan
    Circ J 70:610-4. 2006
    ..Many pathological conditions induce electrical remodeling, possibly through intracellular Ca2+ overload, but the currently available L-type Ca2+ channel blockers may be detrimental because of their global negative inotropic effects...
  68. ncbi Decreasing expression of alpha1C calcium L-type channel subunit mRNA in rat ventricular myocytes upon manganese exposure
    Huijuan Yang
    Department of Biomedical Engineering, Zhejiang University Yuquan Campus, Hangzhou 310027, People s Republic of China
    J Biochem Mol Toxicol 20:159-66. 2006
    ..2, and thus causing long-lasting molecular changes of L-type calcium channel which have probably been triggered by overloading of calcium in myocytes...
  69. ncbi Signature combinatorial splicing profiles of rat cardiac- and smooth-muscle Cav1.2 channels with distinct biophysical properties
    Zhen Zhi Tang
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Blk MD9, 2 Medical Drive, Singapore 117597, Singapore
    Cell Calcium 41:417-28. 2007
    ..The unique sequences in these tissue-specific splice variants may provide the potential targets for drug design and screening...
  70. ncbi Transforming growth factor-beta1 decreases cardiac muscle L-type Ca2+ current and charge movement by acting on the Cav1.2 mRNA
    Guillermo Avila
    G Avila, Dept of Biochemistry, CINVESTAV, Mexico DF 007000, Mexico
    Am J Physiol Heart Circ Physiol 292:H622-31. 2007
    ..Instead, we found that TGF-beta1 decreases the expression levels of atrial Ca(V)1.2 mRNA (70%). Thus TGF-beta1 downregulates atrial L-channel expression and may be therefore contributing to the in vivo cardiac electrical remodeling...
  71. ncbi BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling
    Henrike Berkefeld
    Institute of Physiology, University of Freiburg, Hermann Herder Strasse 7, 79104 Freiburg, Germany
    Science 314:615-20. 2006
    ..Complex formation with distinct Cav channels enables BKCa-mediated membrane hyperpolarization that controls neuronal firing pattern and release of hormones and transmitters in the central nervous system...
  72. ncbi Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits
    Lin Yang
    Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circ Res 101:465-74. 2007
    ..2 current was significantly reduced by coexpression of an alanine-substituted Ca(v)1.2 beta(2a) subunit (Ser(496)). Our results identify a molecular mechanism by which cGMP-PKG regulates Ca(v)1.2 phosphorylation and function...
  73. pmc Molecular determinant for specific Ca/Ba selectivity profiles of low and high threshold Ca2+ channels
    Thierry Cens
    Centre de Recherche de Biochimie Macromoleculaire, UMR 5237 Centre National de la Recherche Scientifique, 34293 Montpellier, France
    J Gen Physiol 130:415-25. 2007
    ..These data therefore attribute to the DCS a unique role in the specific shaping of the Ca(2+) influx between the different HVA channels...
  74. ncbi Ultrastructural evidence for pre- and postsynaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampus
    Alyssa L Tippens
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 506:569-83. 2008
    ..These findings provide the first detailed ultrastructural analysis of Ca(v)1.2 localization in the brain and support functionally diverse roles of these channels in the hippocampal formation...
  75. ncbi Differential splicing patterns of L-type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats
    Zhen Zhi Tang
    Department of Physiology, National University of Singapore, Singapore 117597
    Biochim Biophys Acta 1783:118-30. 2008
    ..2 transcripts identified in SHR hearts provide a different and new perspective in understanding the possible role of molecular remodeling of Cav1.2 channels in cardiac hypertrophy as a consequence of hypertension...
  76. doi Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases
    Jérôme Leroy
    INSERM U 769, Universite Paris Sud 11, Faculte de Pharmacie, 5, rue J B Clement, F 92296 Chatenay Malabry Cedex, France
    Circ Res 102:1091-100. 2008
    ..These results reveal temporally distinct beta-adrenergic receptor cAMP compartments in ARVMs and shed new light on the intricate roles of PDE3 and PDE4...
  77. doi The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells
    Laurentius J A Rampaart
    Department of Neurophysiology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Anesth Analg 106:1778-83. 2008
    ..We have investigated whether Cav1.2/L-type calcium channels may be a target of this butamben action...
  78. pmc L-type calcium channel current up-regulation by chronic stress is associated with increased alpha(1c) subunit expression in rat ventricular myocytes
    Yun Zhao
    Laboratory of Stress Medicine, Institute of Health and Environmental Medicine, Da li Road 1, Tianjin 300050, China
    Cell Stress Chaperones 14:33-41. 2009
    ..Thus, it would provide a new insight into the mechanism of cardiomyocyte injury induced by stress...
  79. pmc Carbon monoxide inhibits L-type Ca2+ channels via redox modulation of key cysteine residues by mitochondrial reactive oxygen species
    Jason L Scragg
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, Level 10, Worsley Bldg, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 283:24412-9. 2008
    ..This in turn leads to redox modulation of any or all of three critical cysteine residues in the channel's cytoplasmic C-terminal tail, resulting in channel inhibition...
  80. doi The role of L- and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles
    Thomas Hartig Braunstein
    Division of Renal and Vascular Research, Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    J Vasc Res 46:138-51. 2009
    ..The roles of intercellular communication and T-type versus L-type voltage-dependent Ca(2+) channels (VDCCs) in conducted vasoconstriction to local KCl-induced depolarization were investigated in mesenteric arterioles...
  81. pmc Angiotensin II causes endothelial-dependent increase in expression of Ca(V)1.2 protein in cultured arteries
    Wen Ze Wang
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205 USA
    Eur J Pharmacol 599:117-20. 2008
    ..2 message. The increase in Ca(V)1.2 protein expression by angiotensin II was abrogated by damaging the endothelium. Thus, the endothelium is involved in regulating Ca(V)1.2 expression in the vascular wall...
  82. pmc Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties
    Xiaoyang Cheng
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Heart Circ Physiol 297:H680-8. 2009
    ..The predominance of exon 1c and 9* in smooth muscle cell Ca(V)1.2 channels causes a hyperpolarizing shift in the voltage sensitivity of currents toward the physiological arterial voltage range...
  83. ncbi lipopolysaccharide induces atrial arrhythmogenesis via down-regulation of L-type Ca2+ channel genes in rats
    Reiko Okazaki
    Department of Internal Medicine, Division of Cardiology, Hepatology, Geriatrics and Integrated Medicine, Nippon Medical School, Tokyo, Japan
    Int Heart J 50:353-63. 2009
    ..LPS induced the down-regulation of L-type calcium channel gene expression and ERP shortening, which might be a mechanism underlying sepsis-induced AF...
  84. ncbi [Altered expression of L-type calcium channel alpha1C and alpha1D subunits in colon of rats with diarrhea-predominant irritable bowel syndrome]
    Jie Zhu
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Zhonghua Yi Xue Za Zhi 89:2713-7. 2009
    ..To investigate the molecular identities of L-type calcium channel alpha1C subunit (Cav1.2) and alpha1D subunit (Cav1.3) responsible for motor dysfunction of diarrhea-predominant irritable bowel syndrome (D-IBS)...
  85. pmc Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries
    Damodaran Narayanan
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis TN 38163, USA
    Circ Res 107:631-41. 2010
    ..Mitochondria can uptake calcium (Ca(2+)), but intracellular Ca(2+) signals that regulate mitochondrial Ca(2+) concentration ([Ca(2+)](mito)) and physiological functions of changes in [Ca(2+)](mito) in arterial myocytes are unclear...
  86. pmc Angiotensin II upregulates Ca(V)1.2 protein expression in cultured arteries via endothelial H(2)O(2) production
    Wenze Wang
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Ark 72205, USA wwang uams edu
    J Vasc Res 48:67-78. 2011
    ..We previously reported that angiotensin II caused an endothelial-dependent increase in L-type voltage-dependent Ca(2+) channel (Ca(V)1.2) in cultured arteries, but the signaling pathways are not clear...
  87. doi The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels
    Chan Young Park
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 330:101-5. 2010
    ..This establishes a previously unknown function for STIM1 and provides a molecular mechanism to explain the reciprocal regulation of these two channels in cells...
  88. pmc The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels
    Youjun Wang
    Department of Biochemistry and Cardiovascular Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Science 330:105-9. 2010
    ..Such coordinated control of the widely expressed Ca(V)1.2 and Orai channels has major implications for Ca(2+) signal generation in excitable and nonexcitable cells...
  89. pmc Analysis of Cav1.2 and ryanodine receptor clusters in rat ventricular myocytes
    David R L Scriven
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Biophys J 99:3923-9. 2010
    ..2 showed no preferential localization and were broadly distributed. These results provide a wealth of morphometric data that are essential for understanding intracellular Ca2+ regulation and modeling Ca2+ dynamics...
  90. pmc The effects of vitamin D receptor silencing on the expression of LVSCC-A1C and LVSCC-A1D and the release of NGF in cortical neurons
    Duygu Gezen-Ak
    Istanbul University, Cerrahpasa Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
    PLoS ONE 6:e17553. 2011
    ..The aim of this study is to investigate LVSCC-A1C, LVSCC-A1D expression levels and NGF release in VDR-silenced primary cortical neurons prepared from Sprague-Dawley rat embryos...
  91. pmc Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation
    Jarkko J Ronkainen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, Neulaniementie 2, FI 70211 Kuopio, Finland
    J Physiol 589:2669-86. 2011
    ..The effect of CaMKII on the α1C-subunit gene (Cacna1c) promoter was abolished by deletion of the downstream regulatory element (DRE), which binds transcriptional ..
  92. pmc Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain
    Alexandre Favereaux
    CNRS, IINS, UMR Central Mechanisms of Pain Sensitization, Bordeaux, France
    EMBO J 30:3830-41. 2011
    ..Moreover, we demonstrate that miR-103 is down-regulated in neuropathic animals and that miR-103 intrathecal applications successfully relieve pain, identifying miR-103 as a novel possible therapeutic target in neuropathic chronic pain...
  93. pmc Rat brain expresses a heterogeneous family of calcium channels
    T P Snutch
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Proc Natl Acad Sci U S A 87:3391-5. 1990
    ..In the regions sequenced, the rat brain class C and D gene products share approximately 75% amino acid identity with the rabbit skeletal muscle Ca channel...
  94. ncbi cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms
    W J Koch
    Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Ohio 45267 0575
    J Biol Chem 265:17786-91. 1990
    ..6- and 12.0-kb mRNA species but not the 6.5-kb species. Southern analysis of rat genomic DNA reveals a low copy number of the gene encoding this type of calcium channel...
  95. ncbi Changes in transcripts encoding calcium channel subunits of rat myometrium during pregnancy
    N Tezuka
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77555, USA
    Am J Physiol 269:C1008-17. 1995
    ..Progesterone withdrawal or blockade appears to be responsible for regulating levels of mRNA for VDCC in the myometrium in preparation for labor...
  96. ncbi Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat
    D L Wendell
    Department of Biochemistry, University of Wisconsin Madison 53706 1569, USA
    Mamm Genome 8:823-9. 1997
    ..We also find evidence for interaction (epistasis) between Edpm3 and Edpm9 and between Edpm5 and the suggested QTL on Chr 14...
  97. pmc Modulation of Ca2+ signalling in rat atrial myocytes: possible role of the alpha1C carboxyl terminal
    Sun Hee Woo
    Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20057, USA
    J Physiol 552:437-47. 2003
    ....
  98. ncbi Functional stoichiometry and local enrichment of calmodulin interacting with Ca2+ channels
    Masayuki X Mori
    Ca2 Signals Laboratory, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Science 304:432-5. 2004
    ..This estimate indicates marked enrichment of local CaM, as if a "school" of nearby CaMs were poised to enhance the transduction of local Ca2+ entry into diverse signaling pathways...
  99. ncbi A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C
    Dongjun Li
    Department of Physiology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Neurosci 25:1914-23. 2005
    ..Thus, the PP2calpha-Ca2+ channel complex is responsible for rapid dephosphorylation of Ca2+ channels and may contribute to regulation of synaptic transmission in neurons...
  100. ncbi Expression of multiple CaV1.2 transcripts in rat tissues mediated by different promoters
    Nehad I Saada
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 0641, USA
    Cell Calcium 37:301-9. 2005
    ..Evidence in favor of still another promoter upstream of exon 2 has been uncovered...