fibroblast growth factor receptor 2

Summary

Gene Symbol: fibroblast growth factor receptor 2
Description: fibroblast growth factor receptor 2
Alias: fibroblast growth factor receptor 2
Species: rat

Top Publications

  1. pmc Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells
    P Savagner
    Laboratoire de Physiopathologie du Developpement, Centre National de la Recherche Scientifique Ecole Normale Supérieure, Paris, France
    Mol Biol Cell 5:851-62. 1994
  2. ncbi Ethanol exposure during embryogenesis decreases the radial glial progenitorpool and affects the generation of neurons and astrocytes
    Gemma Rubert
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurosci Res 84:483-96. 2006
  3. doi Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP
    Jun Tao Jiang
    Department of Urology, Shanghai First People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Toxicology 338:77-85. 2015
  4. doi Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes
    Roopa Purushothaman
    Department of Oral Biology, University of Washington, Seattle, USA
    Birth Defects Res A Clin Mol Teratol 91:603-9. 2011
  5. pmc Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation
    Peter F Nichol
    University of Wisconsin School of Medicine and Public Health Department of Surgery, Madison, WI 53792, USA
    J Pediatr Surg 46:90-6. 2011
  6. doi Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China
    Xiao Hui Chen
    Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Hexi District, Tianjin, 300060, China
    Breast Cancer Res Treat 125:575-82. 2011
  7. doi Endotoxin alters early fetal lung morphogenesis
    Christopher S Muratore
    Department of Surgery, Pediatric Surgery, Hasbro Children s Hospital, Brown University, Providence, Rhode Island 02095, USA
    J Surg Res 155:225-30. 2009
  8. ncbi Fibroblast growth factor expression in the postnatal growth plate
    Jacob E Lazarus
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Bone 40:577-86. 2007
  9. pmc Analysis of phenotypic features and FGFR2 mutations in Apert syndrome
    W J Park
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Am J Hum Genet 57:321-8. 1995
  10. pmc Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation
    Kenneth E White
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Hum Genet 76:361-7. 2005

Research Grants

Scientific Experts

  • T Kanda
  • Christopher S Muratore
  • Peter F Nichol
  • R Bansal
  • Ann E Drummond
  • Monica McGrath
  • Zhen Zhen Zhao
  • P M Pollock
  • M Manavi
  • Eleftherios Vairaktaris
  • P Claus
  • Emma McCann
  • Alex Agrotis
  • DAVID JOHN HUNTER
  • Chengliu Jin
  • Mariano A Garcia-Blanco
  • Wallace L McKeehan
  • Fen Wang
  • Jun Tao Jiang
  • Ana Lonic
  • Florian Friedmacher
  • Eric J Wagner
  • Roopa Purushothaman
  • Daniela Q C M Barge-Schaapveld
  • Xiao Hui Chen
  • Andrew P Baraniak
  • Chaofeng Yang
  • M R Bryant
  • Jiyoung Y Cha
  • Yongde Luo
  • Mami Tsuchioka
  • Cecile Rouzier
  • Renata Fonseca
  • Annika C Schuller
  • Amit Dutt
  • Fuminori Taniguchi
  • H Y Leung
  • Douglas F Easton
  • Jacob E Lazarus
  • Gemma Rubert
  • Sebastian Oltean
  • Andreas Andreou
  • Tamuna Chadashvili
  • W L McKeehan
  • Kenneth E White
  • HanJoon M Song
  • Ruben H Hovhannisyan
  • Ayca Cinaroglu
  • Clotilde Billottet
  • Nicole D Robson-Dixon
  • Troy L Spilde
  • P Mehta
  • Munehiko Onda
  • Phillip J Albrecht
  • Quan Yuan
  • Zhi Hong Liu
  • Wei Zhao
  • Shu Jie Xia
  • Kristofer Wood
  • Dong liang Xu
  • Yi Ping Zhu
  • En Hui Li
  • Hong Li Xu
  • Wen lan Sun
  • Benyoussef Naimi
  • Zhi Sheng Jiang
  • Lynda Elghazi
  • Nhan Truong
  • Daniel Thomas
  • Yang Kong
  • Jessica K Holien
  • Jason A Powell
  • Michael W Parker
  • Mark A Guthridge
  • R B Jones
  • Balazs Kutasy
  • Naho Fujiwara
  • Takashi Doi
  • Prem Puri
  • Jan Hendrik Gosemann
  • I A Steele
  • Xiao Qing Li
  • A Murat Maga
  • Rosalinda van Spaendonk
  • Xiaochong Wu
  • Michael L Cunningham
  • Ying Chen
  • Alice S Brooks
  • R Jeroen Vermeulen
  • Timothy C Cox

Detail Information

Publications65

  1. pmc Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells
    P Savagner
    Laboratoire de Physiopathologie du Developpement, Centre National de la Recherche Scientifique Ecole Normale Supérieure, Paris, France
    Mol Biol Cell 5:851-62. 1994
    ..Such transfected cells could bind bFGF as well as aFGF. Therefore, EMT can be induced through different FGF receptors, but EMT may also regulate FGF receptor expression itself...
  2. ncbi Ethanol exposure during embryogenesis decreases the radial glial progenitorpool and affects the generation of neurons and astrocytes
    Gemma Rubert
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurosci Res 84:483-96. 2006
    ..Moreover, levels of activated Notch1 and fibroblast growth factor receptor 2, which regulate the maintenance of the progenitor state of RG, are decreased by prenatal ethanol ..
  3. doi Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP
    Jun Tao Jiang
    Department of Urology, Shanghai First People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Toxicology 338:77-85. 2015
    ..Our findings suggest the potential involvement of altered Fgf10/Fgfr2 signaling and AR in pathogenesis of local and systemic development defects in ARMs male rats induce by DBP...
  4. doi Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes
    Roopa Purushothaman
    Department of Oral Biology, University of Washington, Seattle, USA
    Birth Defects Res A Clin Mol Teratol 91:603-9. 2011
    ..Our results indicate that midfacial hypoplasia is not secondary to premature cranial base ossification but rather primary synostosis of facial sutures. Birth Defects Research (Part A), 2011...
  5. pmc Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation
    Peter F Nichol
    University of Wisconsin School of Medicine and Public Health Department of Surgery, Madison, WI 53792, USA
    J Pediatr Surg 46:90-6. 2011
    ..We observed that fibroblast growth factor receptors 1 and 2 (Fgfr1, Fgfr2) are expressed during abdominal wall development in mice and hypothesized that conditional mutation of these genes would result in abdominal wall defects...
  6. doi Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China
    Xiao Hui Chen
    Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Hexi District, Tianjin, 300060, China
    Breast Cancer Res Treat 125:575-82. 2011
    ..SNP rs1982073 (Leu10Pro) in transforming growth factor-beta 1 (TGFB1) gene and the SNP rs1219648 in fibroblast growth factor receptor 2 (FGFR2) gene with the risk and aggressiveness of breast cancer among women of Han nationality in ..
  7. doi Endotoxin alters early fetal lung morphogenesis
    Christopher S Muratore
    Department of Surgery, Pediatric Surgery, Hasbro Children s Hospital, Brown University, Providence, Rhode Island 02095, USA
    J Surg Res 155:225-30. 2009
    ....
  8. ncbi Fibroblast growth factor expression in the postnatal growth plate
    Jacob E Lazarus
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Bone 40:577-86. 2007
    ..We also found temporal changes in FGF and FGFR expression which may contribute to growth plate senescence and thus help determine the size of the adult skeleton...
  9. pmc Analysis of phenotypic features and FGFR2 mutations in Apert syndrome
    W J Park
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Am J Hum Genet 57:321-8. 1995
    ..These results are not unexpected, because the two common mutations for Apert syndrome alter FGFR2 at adjacent amino acids that are likely to have similar biological, and therefore phenotypic, consequences...
  10. pmc Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation
    Kenneth E White
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Hum Genet 76:361-7. 2005
    ....
  11. ncbi High-dose retinoic acid modulates rat calvarial osteoblast biology
    HanJoon M Song
    The Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
    J Cell Physiol 202:255-62. 2005
    ..both mRNA and protein analysis of FGF receptor isoforms demonstrated a switch in predominance from fibroblast growth factor receptor 2 (fgfr2) to fgfr1. Analysis of PCNA protein confirmed inhibition of proliferation by retinoic acid...
  12. pmc Targets of fibroblast growth factor 1 (FGF-1) and FGF-2 signaling involved in the invasive and tumorigenic behavior of carcinoma cells
    Clotilde Billottet
    Laboratory of Cell Morphogenesis and Tumor Progression, UMR 144 CNRS, Institut Curie, Section de Recherche, 75248 Paris Cedex 05, France
    Mol Biol Cell 15:4725-34. 2004
    ..These molecular analyses show that the potential of these two growth factors in tumor progression is highly dependent on specific FGFR signaling and highlights its importance as a target for antitumor therapy...
  13. ncbi Evidence for fibroblast growth factor receptors in myofibroblasts during palatal mucoperiosteal repair
    T Kanda
    Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Japan
    Arch Oral Biol 48:213-21. 2003
    ..These findings suggest that FGFR1 and FGFR2 in myofibroblasts may be responsible for the signal transduction of FGF during the wound healing process...
  14. ncbi FGF-2 converts mature oligodendrocytes to a novel phenotype
    R Bansal
    Department of Pharmacology, University of Connecticut Medical School, Farmington 06030 3205, USA
    J Neurosci Res 50:215-28. 1997
    ..In particular, on the basis of these data we predict the appearance of cells in and around multiple sclerosis plaques with the phenotype O4+, NG2-, A2B5-, O1-, MBP-...
  15. doi Upregulation of fibroblast growth factor receptor 2 and 3 in the late stages of fetal lung development in the nitrofen rat model
    Florian Friedmacher
    National Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 28:195-9. 2012
    ..We designed this study to test the hypothesis that FGFR gene expression is upregulated in the late stages of lung development in the nitrofen CDH model...
  16. pmc Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation
    Ana Lonic
    Cell Growth and Differentiation Laboratory, Division of Human Immunology, South Australian Pathology, Adelaide, South Australia 5000, Australia
    J Biol Chem 288:14874-85. 2013
    ..Our findings show that in addition to FGFR tyrosine phosphorylation, the phosphorylation of a conserved serine residue, Ser(779), can quantitatively control Ras/MAPK signaling to promote specific cellular responses...
  17. ncbi Novel phenotype of craniosynostosis and ocular anterior chamber dysgenesis with a fibroblast growth factor receptor 2 mutation
    Emma McCann
    Department of Clinical Genetics, Royal Liverpool Children s Hospital, Liverpool, UK
    Am J Med Genet A 138:278-81. 2005
    b>Fibroblast growth factor receptor 2 (FGFR2) mutations are associated with syndromic and non-syndromic craniosynostoses...
  18. doi Beare-Stevenson syndrome: two Dutch patients with cerebral abnormalities
    Daniela Q C M Barge-Schaapveld
    Department of Paediatric Genetics, Academic Medical Centre, Amsterdam, The Netherlands
    Pediatr Neurol 44:303-7. 2011
    ..In 1996, two mutations in the fibroblast growth factor receptor 2 gene were found to cause this syndrome, thereby including BSS in the fibroblast growth factor ..
  19. doi Second case of Beare-Stevenson syndrome with an FGFR2 Ser372Cys mutation
    Renata Fonseca
    ECLAMC Estudo Colaborativo Latino Americano de Malformações Congênitas at Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Am J Med Genet A 146:658-60. 2008
    ..Reported causes are an FGFR2 Tyr375Cys mutation in nine cases and an FGFR2 Ser372Cys mutation in one case. Here, we report on a second patient with the FGFR2 Ser372Cys mutation...
  20. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci...
  21. doi Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells
    Mami Tsuchioka
    Division of Psychiatry and Neuroscience, Institute of Clinical Research, National Hospital Organization NHO, Kure Medical Center and Chugoku Cancer Center, Kure, Japan
    J Neurochem 106:244-57. 2008
    ..In conclusion, our findings suggest that 5-HT induces GDNF mRNA expression via 5-HT(2)R-mediated FGFR2 transactivation in C6 cells...
  22. pmc Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, QLD 4029, Australia
    Hum Reprod 23:1661-8. 2008
    ..Epidemiological data support a link between endometriosis and cancers of the reproductive tract. Fibroblast growth factor receptor 2 (FGFR2) has recently been implicated in both endometrial and breast cancer...
  23. ncbi Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation
    Annika C Schuller
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 410:205-11. 2008
    ..gain-of-function point mutations (S252W and P253R) in the extracellular region of the FGFR2 (fibroblast growth factor receptor 2) increase the binding affinity for the growth factor...
  24. ncbi Diabetes does not influence oral oncogenesis through fibroblast growth factor receptors
    Eleftherios Vairaktaris
    Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens, Greece
    In Vivo 21:623-8. 2007
    ..The expression of FGFR-2 and FGFR-3 investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) rats...
  25. pmc Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes
    M R Bryant
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    Glia 57:935-46. 2009
    ....
  26. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  27. pmc Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
    P M Pollock
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA
    Oncogene 26:7158-62. 2007
    ..The discovery of activating FGFR2 mutations in endometrial carcinoma raises the possibility of employing anti-FGFR molecularly targeted therapies in patients with advanced or recurrent endometrial carcinoma...
  28. ncbi Fibroblast growth factor-9, a local regulator of ovarian function
    Ann E Drummond
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Endocrinology 148:3711-21. 2007
    ..In summary, the data are consistent with a paracrine role for FGF9 in the ovary...
  29. pmc Drug-sensitive FGFR2 mutations in endometrial carcinoma
    Amit Dutt
    Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8713-7. 2008
    ..Here, we show that somatic mutations of the fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase gene, FGFR2, are present in 12% of endometrial carcinomas, with additional ..
  30. pmc Novel breast cancer risk alleles and endometrial cancer risk
    Monica McGrath
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, MA 02115, USA
    Int J Cancer 123:2961-4. 2008
    ..The molecular mechanisms underlying these differences remain to be defined...
  31. ncbi Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma
    Mahmood Manavi
    Department of Gynecology and Obstetrics, Division of Special Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gynecol Oncol 105:418-26. 2007
    ....
  32. pmc Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform
    Jiyoung Y Cha
    Lineberger Comprehensive Cancer Center, Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 284:6227-40. 2009
    Alternative splice variants of fibroblast growth factor receptor 2 (FGFR2) IIIb, designated C1, C2, and C3, possess progressive reduction in their cytoplasmic carboxyl termini (822, 788, and 769 residues, respectively), with preferential ..
  33. pmc Novel phosphotyrosine targets of FGFR2IIIb signaling
    Yongde Luo
    IBT Proteomics and Nanotechnology Laboratory, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas 77030 3303, USA
    Cell Signal 21:1370-8. 2009
    ..Our findings provide specific downstream targets for dissection of causal relationships underlying the distinct role of FGF7/FGFR2IIIb signaling in epithelial cell homeostasis...
  34. ncbi Keratinocyte growth factor expression in hormone insensitive prostate cancer
    H Y Leung
    Department of Surgery, The Medical School, University of Newcastle upon Tyne, UK
    Oncogene 15:1115-20. 1997
    ..Functional assessment of recombinant KGF in a proliferation assay demonstrated a mitogenic effect of up to 100% on cultured prostatic epithelial cells...
  35. ncbi Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas
    S G Diez de Medina
    UMR 144, CNRS Institut Curie, Paris, France
    Oncogene 14:323-30. 1997
    Growth factors and growth factor receptors are involved in tumor progression. The fibroblast growth factor receptor 2 gene encodes distinct isoforms...
  36. ncbi Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs
    A Miyake
    Department of Genetic Biochemistry, Kyoto University Faculty of Pharmaceutical Sciences, Japan
    J Neurosci Res 45:534-41. 1996
    ..The expression of FGFR-2 IIIc and FGFR-3 IIIc with different ligand specificities might play important roles in the various effects of FGFs on oligodendrocytes and astrocytes...
  37. ncbi Exon skipping causes alteration of the COOH-terminus and deletion of the phospholipase C gamma 1 interaction site in the FGF receptor 2 kinase in normal prostate epithelial cells
    G Yan
    W Alton Jones Cell Science Center, Inc, Lake Placid, NY 12946
    Biochem Biophys Res Commun 194:512-8. 1993
    ..When combined with the same FGFR2 extracellular domain, co-expression of the two COOH-terminal variants may mediate effect of the same FGF ligand on different signal transduction pathways...
  38. pmc FGFR3-expressing smooth muscle-like stromal cells differentiate in response to FGFR2IIIb-expressing prostate tumor cells and delay tumor progression
    Chengliu Jin
    Center for Cancer and Stem Cell Biology, Texas A and M Health Science Center, Institute of Biosciences and Technology, 2121 W Holcombe Blvd, Houston, TX 77030 3303, USA
    In Vitro Cell Dev Biol Anim 47:500-5. 2011
    ..These results highlight the importance of the two-way communication back and forth between stroma and epithelium that is mediated by signaling within the FGFR family during progression to malignancy...
  39. ncbi Proliferation of neointimal smooth muscle cells after arterial injury. Dependence on interactions between fibroblast growth factor receptor-2 and fibroblast growth factor-9
    Alex Agrotis
    Cell Biology Laboratory, Baker Heart Research Institute, St Kilda Road Central, P O Box 6492, Melbourne 8008, Victoria, Australia
    J Biol Chem 279:42221-9. 2004
    ..These studies demonstrate that, although multiple FGFRs are induced in neointimal SMCs following arterial injury, specific interactions between distinctly spliced FGFR-2 isoforms and FGF-9 contribute to the proliferation of these SMCs...
  40. ncbi Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C
    Zhi Sheng Jiang
    Department of Human Anatomy, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R2H 2A6
    Am J Physiol Heart Circ Physiol 282:H1071-80. 2002
    ....
  41. pmc Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation
    Lynda Elghazi
    Institut National de la Santé et de la Recherche Médicale U457, Hospital R Debre, 48, boulevard Serurier, 75019 Paris, France
    Proc Natl Acad Sci U S A 99:3884-9. 2002
    ..Thus, efficient propagation of pancreatic progenitor cells can be achieved in vitro by exposure to FGF7, which does not affect their ability to differentiate en masse into endocrine cells on FGF7 removal...
  42. ncbi Down-regulation of (IIIb) and (IIIc) isoforms of fibroblast growth factor receptor 2 (FGFR2) is associated with malignant progression in human prostate
    Benyoussef Naimi
    UroGene, Genopole, Evry, France
    Prostate 52:245-52. 2002
    ..Imbalance in expression of these factors is associated with malignancy in several cancers...
  43. ncbi Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein
    Peter Claus
    Department of Neuroanatomy, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 278:479-85. 2003
    ..Patients with spinal muscular atrophy suffer from fatal degeneration of motoneurons because of mutations and deletions of the gene for the SMN protein...
  44. ncbi Expression of keratinocyte growth factor receptor (KGFR/FGFR2 IIIb) in vascular smooth muscle cells
    Munehiko Onda
    Department of Pathology, Nippon Medical School and Division of Surgical Pathology, Nippon Medical School Hospital, Tokyo, Japan
    Pathol Int 53:127-32. 2003
    ..Recombinant FGF-7 and/or FGF-10 proteins stimulated the growth of cultured rat VSMC. These findings indicate that KGFR localized in VSMC may contribute to the proliferation of VSMC in normal and atherosclerotic arteries...
  45. ncbi Fibroblast growth factor receptor-2 mutation analysis in human prostate cancer
    P Mehta
    School of Surgical Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    BJU Int 86:681-5. 2000
    ..The human prostate cell lines, LNCaP, PC3, DU145, PNT1A and PNT1B were also examined. In addition, 10 foci of invasive cancer from three patients who underwent radical prostatectomy were also assessed...
  46. ncbi Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production
    Phillip J Albrecht
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Neurobiol Dis 13:89-101. 2003
    ..Altogether, these results strongly implicate CNTF as an important cytokine in demyelinating disease and as an upstream regulator of FGF-2 production in astrocytes during early remyelination...
  47. pmc A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements
    Andrew P Baraniak
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 23:9327-37. 2003
    Alternative splicing of fibroblast growth factor receptor 2 (FGFR2) occurs in a cell-type-specific manner with the mutually exclusive use of exon IIIb or exon IIIc...
  48. ncbi Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate
    Chengliu Jin
    Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030 3303, USA
    Cancer Res 63:8784-90. 2003
    ..The bigenic mice provide a model with cooperative aberrations in the fibroblast growth factor signaling axis for evaluation of tumor-initiating events in prostate tumorigenesis...
  49. ncbi Aberrant fibroblast growth factor receptor 2 signalling in esophageal atresia with tracheoesophageal fistula
    Troy L Spilde
    Children s Mercy Hospital Laboratory for Surgical Organogenesis, Kansas City, MO 64108, USA
    J Pediatr Surg 39:537-9. 2004
    ..To characterize FGF signaling in the developing EA/TEF, the authors analyzed levels of FGF2R splice variants in experimental EA/TEF...
  50. ncbi MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb
    Nicole D Robson-Dixon
    Departments of Molecular Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:29075-84. 2004
    The fibroblast growth factor receptor 2 (FGFR2) gene exons IIIb and IIIc are alternatively spliced in a mutually exclusive and cell type-specific manner. FGFR2 exon choice depends on both activation and silencing...
  51. ncbi The nonsense-mediated decay pathway and mutually exclusive expression of alternatively spliced FGFR2IIIb and -IIIc mRNAs
    R B Jones
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 276:4158-67. 2001
    ..The nonsense-mediated mRNA decay pathway and cell type-dependent rates of inclusion of exons IIIb and IIIc result in the mutually exclusive expression of FGFR2IIIb and IIIc...
  52. ncbi Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma
    Fuminori Taniguchi
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Fertil Steril 89:478-80. 2008
    ....
  53. ncbi Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer
    D Ricol
    UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Oncogene 18:7234-43. 1999
    ..Altogether, these results show that FGFR2-IIIb has tumour growth suppressive properties in bladder carcinomas and suggest possible mechanisms of FGFR2 gene inactivation...
  54. pmc A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence
    Ruben H Hovhannisyan
    University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
    Mol Cell Biol 25:250-63. 2005
    Mutually exclusive splicing of fibroblast growth factor receptor 2 (FGFR2) exons IIIb and IIIc yields two receptor isoforms, FGFR2-IIIb and -IIIc, with distinctly different ligand binding properties...
  55. ncbi Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina
    Ayca Cinaroglu
    Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey
    J Neurosci Res 79:329-39. 2005
    ..These data suggest a role for FGF9 in retinal differentiation and maturation, possibly representing a neuronally derived factor acting upon glial (and other) cells...
  56. ncbi Inhibition of growth of malignant rat prostate tumor cells by restoration of fibroblast growth factor receptor 2
    A Matsubara
    Center for Cancer Biology and Nutrition, Albert B Alkek Institute of Biosciences and Technology, and Department of Biochemistry and Biophysics, Texas A and M University, Houston 77030 3303, USA
    Cancer Res 58:1509-14. 1998
    ..Restoration of the FGFR2 kinase to malignant tumors that are refractory to treatment may present a new avenue for gene therapy...
  57. ncbi Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb
    Eric J Wagner
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:14017-27. 2005
    ..Our data defined elements of function within the ISSs flanking exon IIIb and suggested that silencing of this exon is mediated by multiple trans-acting factors...
  58. pmc An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing
    R P Carstens
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 18:2205-17. 1998
    Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) is an example of highly regulated alternative splicing in which exons IIIb and IIIc are utilized in a mutually exclusive manner in different cell types...
  59. ncbi Cytoarchitecture of fibroblast growth factor receptor 2 (FGFR-2) immunoreactivity in astrocytes of neurogenic and non-neurogenic regions of the young adult and aged rat brain
    Tamuna Chadashvili
    Neural Repair and Neurogenesis Laboratory, Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, Chicago, Illinois 60064, USA
    J Comp Neurol 498:1-15. 2006
    ..Thus, FGF-2 biological effects on astrocytes appear to be mediated through FGFR-2-dependent mechanisms, and this may provide an indirect route by which FGF-2 acts on neuronal populations...
  60. pmc Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity
    Sebastian Oltean
    Department of Molecular Genetics and Microbiology, Center for RNA Biology, and University Program in Genetics and Genomics, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:14116-21. 2006
    In epithelial cells, alternative splicing of fibroblast growth factor receptor 2 (FGFR2) transcripts leads to the expression of the FGFR2(IIIb) isoform, whereas in mesenchymal cells, the same process results in the synthesis of FGFR2(..
  61. ncbi Early-onset low-grade papillary carcinoma of the bladder associated with Apert syndrome and a germline FGFR2 mutation (Pro253Arg)
    Andreas Andreou
    Department of Urology, Rouen University Hospital, Rouen, France
    Am J Med Genet A 140:2245-7. 2006
  62. ncbi Ovarian dysgerminoma and Apert syndrome
    Cecile Rouzier
    Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Faculty of Medicine, Nice, France
    Pediatr Blood Cancer 50:696-8. 2008
    ..This is the second report of the association of Apert syndrome with cancer. Our observation raises the hypothesis of a role for FGFR2 mutations in tumorigenesis...
  63. ncbi Induction of FGF receptor 2-IIIb expression and response to its ligands in epithelial ovarian cancer
    I A Steele
    Department of Surgery, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Oncogene 20:5878-87. 2001
    ..b>Fibroblast Growth Factor Receptor 2 isoform IIIb (FGF receptor 2-IIIb) is a spliced variant of FGF receptor 2 that binds the ligands ..

Research Grants2

  1. COHORT STUDY OF GENETIC MARKERS IN COLON CANCER
    David Hunter; Fiscal Year: 2005
    ..They conclude that confirmation of risk genotypes would also be useful in identifying persons at high risk of colon cancer and assist in focusing screening efforts. ..
  2. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    DAVID JOHN HUNTER; Fiscal Year: 2010
    ..Understanding the causes of the age-related shortening of telomeres may offer modifiable means of reducing breast cancer risk. ..