Gja4

Summary

Gene Symbol: Gja4
Description: gap junction protein, alpha 4
Alias: CXN37, gap junction alpha-4 protein, Gap junction membrane channel, protein alpha 4 (connexin 37), connexin-37, cx37, gap junction membrane channel protein alpha 4
Species: rat

Top Publications

  1. pmc Structural determinants and proliferative consequences of connexin 37 hemichannel function in insulinoma cells
    Miranda E Good
    From the Department of Physiology, University of Arizona, Tucson, Arizona 85724 5051
    J Biol Chem 289:30379-86. 2014
  2. pmc Impact of 7,12-dimethylbenz[a]anthracene exposure on connexin gap junction proteins in cultured rat ovaries
    Shanthi Ganesan
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA Electronic address
    Toxicol Appl Pharmacol 274:209-14. 2014
  3. pmc Carboxy terminus and pore-forming domain properties specific to Cx37 are necessary for Cx37-mediated suppression of insulinoma cell proliferation
    Tasha K Nelson
    Department of Physiology, University of Arizona, Tucson, Arizona and
    Am J Physiol Cell Physiol 305:C1246-56. 2013
  4. ncbi Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium
    H I Yeh
    Departments of Internal Medicine and Medical Research, Mackay Memorial Hospital, Taipei Medical College, Taipei, Taiwan
    J Histochem Cytochem 48:1377-89. 2000
  5. ncbi Expression of connexins in the normal and obstructed developing kidney
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Pediatr Nephrol 18:216-24. 2003
  6. ncbi Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries
    Scott Earley
    Dept of Cell Biology and Physiology, MSC08 4750, 1 Univ of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Heart Circ Physiol 287:H2677-86. 2004
  7. pmc Differential endothelial gap junction expression in venous vessels exposed to different hemodynamics
    Chi Jen Chang
    The First Cardiovascular Division, Chang Gung Memorial Hospital, 5 Fu Hsing St, Kuei Shan, Tao Yuan, Taiwan
    J Histochem Cytochem 58:1083-92. 2010
  8. doi Connexin 37 is localized in renal epithelia and responds to changes in dietary salt intake
    Adelina Stoessel
    Institute of Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Physiol Renal Physiol 298:F216-23. 2010
  9. doi Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat
    A Trovato-Salinaro
    Dept of Experimental Medicine, Section of Human Physiology, Univ of Palermo, Corso Tukory 129, 90134 Palermo, Italy
    Am J Physiol Cell Physiol 296:C593-606. 2009
  10. ncbi Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical College, Iruma Saitama, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R1-11. 2008

Scientific Experts

  • Shanthi Ganesan
  • Yoshiji Yamada
  • D M Silverstein
  • Nicole M Rummery
  • H I Yeh
  • Miranda E Good
  • Janis M Burt
  • Tasha K Nelson
  • Chi Jen Chang
  • Adelina Stoessel
  • A Trovato-Salinaro
  • Tsuneo Takenaka
  • Florinda Listi
  • Scott Earley
  • Xavier F Figueroa
  • N J Severs
  • Yasuo Kansui
  • Jose F Ek-Vitorin
  • S H Lin
  • Paul L Sorgen
  • Gwo Jyh Chang
  • Sebastian Bachmann
  • Chin Fen Chen
  • Yu Shien Ko
  • Nina Himmerkus
  • C H Tsai
  • Markus Bleich
  • Lung An Hsu
  • Franziska Theilig
  • H M Chang
  • Lung Sheng Wu
  • Hung I Yeh
  • Y S Ko
  • G Mudo
  • J von Maltzahn
  • N Belluardo
  • K Willecke
  • D F Condorelli
  • M Frinchi
  • Hiromichi Suzuki
  • Hirokazu Okada
  • Yoshihiko Kanno
  • Caryl E Hill
  • Tsutomu Inoue
  • Domenico Lio
  • Marco Caruso
  • Mariangela Russo
  • Giuseppina Colonna-Romano
  • Calogero Caruso
  • Enrico Hoffmann
  • Giuseppina Candore
  • Hideyuki Oniki
  • Mitsuo Iida
  • Brian R Duling
  • Thomas C Resta
  • Keiichiro Nakamura
  • Kenichi Goto
  • Brant E Isakson
  • Koji Fujii
  • Isao Abe
  • Benjimen R Walker
  • Yosaburo Shibata
  • F D Vrionis
  • P C Wu
  • R Muhammad
  • F C Lin
  • L C Yang
  • W Y Chou
  • C Y Lu
  • C R Lin
  • Y N Lee
  • Y J Lai
  • W W Lu
  • S Rothery
  • E Dupont
  • S R Coppen
  • J K Wu
  • V Cherington
  • P Qi
  • D C Spray
  • M Waltzman
  • J A Haefliger
  • R Bruzzone
  • N G Copeland
  • N A Jenkins
  • D J Gilbert
  • D L Paul

Detail Information

Publications20

  1. pmc Structural determinants and proliferative consequences of connexin 37 hemichannel function in insulinoma cells
    Miranda E Good
    From the Department of Physiology, University of Arizona, Tucson, Arizona 85724 5051
    J Biol Chem 289:30379-86. 2014
    ..The C terminus and a channel able to function are necessary, and neither by itself is sufficient, for Cx37 to mediate growth suppression...
  2. pmc Impact of 7,12-dimethylbenz[a]anthracene exposure on connexin gap junction proteins in cultured rat ovaries
    Shanthi Ganesan
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA Electronic address
    Toxicol Appl Pharmacol 274:209-14. 2014
    ..5nM or 75nM) and cultured for 4 or 8days. RT-PCR was performed to quantify Cx37, Cx43, p53 and Bax mRNA level...
  3. pmc Carboxy terminus and pore-forming domain properties specific to Cx37 are necessary for Cx37-mediated suppression of insulinoma cell proliferation
    Tasha K Nelson
    Department of Physiology, University of Arizona, Tucson, Arizona and
    Am J Physiol Cell Physiol 305:C1246-56. 2013
    b>Connexin 37 (Cx37) suppresses cell proliferation when expressed in rat insulinoma (Rin) cells, an effect also manifest in vivo during vascular development and in response to tissue injury...
  4. ncbi Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium
    H I Yeh
    Departments of Internal Medicine and Medical Research, Mackay Memorial Hospital, Taipei Medical College, Taipei, Taiwan
    J Histochem Cytochem 48:1377-89. 2000
    We investigated endothelial gap junctions and their three component connexins, connexin37 (Cx37), Cx40, and Cx43, during growth and senescence in rat aorta by en face immunoconfocal microscopy and electron microscopy...
  5. ncbi Expression of connexins in the normal and obstructed developing kidney
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Pediatr Nephrol 18:216-24. 2003
    ..Our reverse transcription-polymerase chain reaction (RT-PCR) studies demonstrate that Cx30, Cx36, Cx37, Cx40, Cx45, Cx46, and Cx50 are expressed in the kidney...
  6. ncbi Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries
    Scott Earley
    Dept of Cell Biology and Physiology, MSC08 4750, 1 Univ of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Heart Circ Physiol 287:H2677-86. 2004
    ..Immunohistochemical experiments revealed positive staining for connexin 37 (Cx37) in both endothelium and smooth muscle of rat mesenteric arterioles, whereas connexin 43 (Cx43) ..
  7. pmc Differential endothelial gap junction expression in venous vessels exposed to different hemodynamics
    Chi Jen Chang
    The First Cardiovascular Division, Chang Gung Memorial Hospital, 5 Fu Hsing St, Kuei Shan, Tao Yuan, Taiwan
    J Histochem Cytochem 58:1083-92. 2010
    ..and the total gap-junctional areas (TGJAs) of Cx40 and Cx43 were lower than those of the thoracic aorta and that Cx37 was hardly detectable...
  8. doi Connexin 37 is localized in renal epithelia and responds to changes in dietary salt intake
    Adelina Stoessel
    Institute of Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Physiol Renal Physiol 298:F216-23. 2010
    ..Renal vascular expression and hemodynamic impacts have so far been shown for Cx37, Cx40, and Cx43. Additionally, Cx30, Cx30...
  9. doi Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat
    A Trovato-Salinaro
    Dept of Experimental Medicine, Section of Human Physiology, Univ of Palermo, Corso Tukory 129, 90134 Palermo, Italy
    Am J Physiol Cell Physiol 296:C593-606. 2009
    ..Within 24 h from injury, Cx37 expression was upregulated in the endothelial cells of blood vessels, and, 5 days after injury, Cx37-expressing ..
  10. ncbi Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical College, Iruma Saitama, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R1-11. 2008
    ..Intrarenal infusion of (Cx37,43)GAP27 increased autoregulatory index of renal plasma flow (0.06 +/- 0.05 to 0.47 +/- 0.06, n = 6, P < 0...
  11. ncbi Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily
    Florinda Listi
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Int J Cardiol 102:269-71. 2005
    ..The component protein subunits of these channels, called connexin (Cx), belong to a multigene family. Cx37 is involved in growth, regeneration after injury and ageing of the endothelial cells, suggesting its role in ..
  12. ncbi Connexins: gaps in our knowledge of vascular function
    Xavier F Figueroa
    Department of Molecular Physiology and Biological Physics, Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Physiology (Bethesda) 19:277-84. 2004
    ....
  13. ncbi Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
    ..005) associated with CAD: the 1019C -->T of the connexin 37 gene for men with type 2 diabetes; the 2445G -->A in the fatty acid-binding protein 2 gene for women with ..
  14. ncbi Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats
    Yasuo Kansui
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
    Am J Physiol Heart Circ Physiol 287:H216-24. 2004
    ..Confocal laser scanning microscopy after immunofluorescent labeling with antibodies against Cx37, Cx40, and Cx43 revealed that the expression of Cx37 and Cx40 in endothelial cells of the mesenteric artery was ..
  15. ncbi Connexin37 is the major connexin expressed in the media of caudal artery
    Nicole M Rummery
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Arterioscler Thromb Vasc Biol 22:1427-32. 2002
    ..the connexins (Cxs) involved in intercellular coupling within vascular muscle, the present study has quantified mRNA and protein expression for Cx37, Cx40, Cx43, and Cx45 in the caudal artery (CA) and thoracic aorta (ThA) of the rat.
  16. ncbi Induction of connexin 37 expression in a rat model of neuropathic pain
    S H Lin
    Anesthesiology Research Laboratory, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, Kaohsiung Hsien 833, Taiwan
    Brain Res Mol Brain Res 99:134-40. 2002
    ..Changes in connexin 37 mRNA expression following nerve injury have not been previously documented...
  17. ncbi Multiple connexin expression in regenerating arterial endothelial gap junctions
    H I Yeh
    Mackay Memorial Hospital, Taipei Medical College, Department of Internal Medicine, Chang Gung Memorial Hospital, Taiwan
    Arterioscler Thromb Vasc Biol 20:1753-62. 2000
    ....
  18. ncbi Individual gap junction plaques contain multiple connexins in arterial endothelium
    H I Yeh
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, England, UK
    Circ Res 83:1248-63. 1998
    ..Up to 3 connexin types, connexin40 (Cx40), Cx37, and Cx43 may be expressed in vascular endothelium according to vascular site, species, and physiological ..
  19. ncbi The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions
    F D Vrionis
    Department of Neurosurgery, Tufts University School of Medicine, Boston, MA, USA
    Gene Ther 4:577-85. 1997
    ..In conclusion, these results indicate that in several cellular environments the bystander effect is dependent on connexin expression and gap junctional communication between HSVtk-positive and HSVtk-negative cells...
  20. ncbi Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping
    J A Haefliger
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 267:2057-64. 1992
    ..On the basis of their predicted molecular mass, these proteins have been designated connexin (Cx) 40 (Cx40), Cx37, Cx33, and Cx31.1...