Gjd2

Summary

Gene Symbol: Gjd2
Description: gap junction protein, delta 2
Alias: Cx36, Gja9, gap junction delta-2 protein, connexin-36, gap junction alpha-9 protein, gap junction membrane channel protein alpha 9
Species: rat

Top Publications

  1. ncbi Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36
    M R Deans
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 31:477-85. 2001
  2. pmc The role of Cx36 and Cx43 in 4-aminopyridine-induced rhythmic activity in the spinal nociceptive dorsal horn: an electrophysiological study in vitro
    Christopher W P Kay
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
    Physiol Rep 4:. 2016
  3. pmc Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus
    Medina Ceja Laura
    Laboratory of Neurophysiology and Neurochemistry, Department of Cellular and Molecular Biology, CUCBA, University of Guadalajara, camino Ing R Padilla Sánchez 2100, Las Agujas, Nextipac, Zapopan, Jalisco, Mexico
    J Biomed Sci 22:69. 2015
  4. pmc Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses
    M E Rubio
    Departments of Otolaryngology and Neurobiology, University of Pittsburgh Medical School, Pittsburgh, USA
    Neuroscience 303:604-29. 2015
  5. doi Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation
    L P Voytenko
    Department of Cytology, Bogomoletz Institute of Physiology, Kiev, Ukraine Electronic address
    Brain Res 1616:134-45. 2015
  6. doi Developmental changes in the expression level of connexin36 in the rat retina
    Tamás Kovács-Öller
    Department of Experimental Zoology and Neurobiology, University of Pecs, Pecs, Ifjusag Street 6, Hungary
    Cell Tissue Res 358:289-302. 2014
  7. pmc Gap junction proteins in the light-damaged albino rat
    Cindy X Guo
    Department of Optometry and Vision Science, University of Auckland, Auckland, New Zealand New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand
    Mol Vis 20:670-82. 2014
  8. doi Inhibition of connexin 36 hemichannels by glucose contributes to the stimulation of insulin secretion
    Javier Pizarro-Delgado
    Biochemistry Department, Medical School, Complutense University, Madrid, Spain
    Am J Physiol Endocrinol Metab 306:E1354-66. 2014
  9. pmc Connexin36 in gap junctions forming electrical synapses between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse
    W Bautista
    Department of Physiology, Faculty of Medicine, University of Manitoba, 745 Bannatyne Ave, Winnipeg, MB, R3E 0J9, Canada
    Eur J Neurosci 39:771-87. 2014
  10. pmc Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity
    F Allagnat
    Department of Medicine, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne Switzerland
    Cell Death Differ 20:1742-52. 2013

Scientific Experts

  • JOHN RASH
  • Medina Ceja Laura
  • J I Nagy
  • Javier Franco-Pérez
  • Soh Hidaka
  • Nephtali Marina
  • W Wade Kothmann
  • D G Margineanu
  • Jacques Antoine Haefliger
  • Florent Allagnat
  • David Martin
  • Gerard Waeber
  • P Meda
  • Daniele F Condorelli
  • Christopher W P Kay
  • M E Rubio
  • L P Voytenko
  • Tamás Kovács-Öller
  • W Bautista
  • Cindy X Guo
  • Javier Pizarro-Delgado
  • F Allagnat
  • Elizabeth M Hartfield
  • Michele P Zeinieh
  • Siamak Beheshti
  • C P F Carvalho
  • Christiane Köster-Patzlaff
  • Sarah C Schock
  • Dorothee Caille
  • Paolo Meda
  • Agnes Baude
  • J A Haefliger
  • C Ciolofan
  • Amar Abderrahmani
  • Clinton B McCracken
  • G Sohl
  • Sabine Le Gurun
  • Emanuele Sher
  • Anne E King
  • Daniel Ursu
  • O Yu Lykhmus
  • M A Patseva
  • I V Lushnikova
  • E V Isaeva
  • A V Savotchenko
  • G G Skibo
  • M V Skok
  • Monica L Acosta
  • Ana Temperán
  • József Orbán
  • Paloma Alonso-Magdalena
  • Carles Solsona
  • Angel Nadal
  • Henry Tran
  • Elisabet Estil'les
  • Rafael Martín-Del-Río
  • Colin R Green
  • Miklos Nyitrai
  • Anna Nualart-Marti
  • Luis Carlos Barrio
  • Eduard Montanya
  • Bela Volgyi
  • Ilaria Fasciani
  • Helen V Danesh-Meyer
  • Katalin Raics
  • Maria Romero
  • David L Paul
  • Daniel González-Nieto
  • J Tamarit-Rodriguez
  • P Klee
  • Francoise Rohner-Jeanrenaud
  • A K Cardozo
  • Anne Charollais
  • M R Deans
  • A Calabrese
  • Federica Rinaldi
  • Maeve A Caldwell
  • James B Uney
  • Colin P Glover
  • Liang Fong Wong
  • Hoori Sepehri
  • Behrouz Vaziri
  • Jalal Babaie
  • A C Boschero
  • Mohamad A Mikati
  • J C R Santos-Silva
  • A Britan
  • C B Collares-Buzato
  • Mohammad Sayyah
  • Marwan E El-Sabban

Detail Information

Publications36

  1. ncbi Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36
    M R Deans
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 31:477-85. 2001
    ..in such activity, we constructed mice expressing histochemical reporters in place of the gap junction protein Cx36. Localization of the reporter with somatostatin and parvalbumin suggested that Cx36 was expressed largely by ..
  2. pmc The role of Cx36 and Cx43 in 4-aminopyridine-induced rhythmic activity in the spinal nociceptive dorsal horn: an electrophysiological study in vitro
    Christopher W P Kay
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
    Physiol Rep 4:. 2016
    ..RT-qPCR) was used to profile developmental expression of two specific Cx proteins, namely glial Cx43 and neuronal Cx36, in postnatal lumbar spinal cord aged 4, 7, and 14 days...
  3. pmc Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus
    Medina Ceja Laura
    Laboratory of Neurophysiology and Neurochemistry, Department of Cellular and Molecular Biology, CUCBA, University of Guadalajara, camino Ing R Padilla Sánchez 2100, Las Agujas, Nextipac, Zapopan, Jalisco, Mexico
    J Biomed Sci 22:69. 2015
    ..In these animals, convulsive behavior and EEG signals were analyzed...
  4. pmc Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses
    M E Rubio
    Departments of Otolaryngology and Neurobiology, University of Pittsburgh Medical School, Pittsburgh, USA
    Neuroscience 303:604-29. 2015
    Electrical synapses formed by gap junctions composed of connexin36 (Cx36) are widely distributed in the mammalian central nervous system (CNS)...
  5. doi Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation
    L P Voytenko
    Department of Cytology, Bogomoletz Institute of Physiology, Kiev, Ukraine Electronic address
    Brain Res 1616:134-45. 2015
    ..GABAergic signaling, nicotinic receptors expressing α7-subunit (α7nAChRs(+)) and connexin-36 (Cx36(+), electrotonic gapjunctions protein) contradictory modulate post-ischemic environment...
  6. doi Developmental changes in the expression level of connexin36 in the rat retina
    Tamás Kovács-Öller
    Department of Experimental Zoology and Neurobiology, University of Pecs, Pecs, Ifjusag Street 6, Hungary
    Cell Tissue Res 358:289-302. 2014
    Connexin36 (Cx36) is the major gap junction forming protein in the brain and the retina; thus, alterations in its expression indicate changes in the corresponding circuitry...
  7. pmc Gap junction proteins in the light-damaged albino rat
    Cindy X Guo
    Department of Optometry and Vision Science, University of Auckland, Auckland, New Zealand New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand
    Mol Vis 20:670-82. 2014
    ..We hypothesized that gap junctions are important mediators in tissue dysfunction and injury processes in the retina, and therefore, we investigated the pattern of connexin protein expression in the light-damaged albino rat eye...
  8. doi Inhibition of connexin 36 hemichannels by glucose contributes to the stimulation of insulin secretion
    Javier Pizarro-Delgado
    Biochemistry Department, Medical School, Complutense University, Madrid, Spain
    Am J Physiol Endocrinol Metab 306:E1354-66. 2014
    The existence of functional connexin36 (Cx36) hemichannels in β-cells was investigated in pancreatic islets of rat and wild-type (Cx36(+/+)), monoallelic (Cx36(+/-)), and biallelic (Cx36(-/-)) knockout mice...
  9. pmc Connexin36 in gap junctions forming electrical synapses between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse
    W Bautista
    Department of Physiology, Faculty of Medicine, University of Manitoba, 745 Bannatyne Ave, Winnipeg, MB, R3E 0J9, Canada
    Eur J Neurosci 39:771-87. 2014
    ..linked by gap junctions, we examined immunofluorescence labeling for the gap junction-forming protein connexin36 (Cx36) in male and female mice and rats...
  10. pmc Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity
    F Allagnat
    Department of Medicine, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne Switzerland
    Cell Death Differ 20:1742-52. 2013
    Cell-to-cell communication mediated by gap junctions made of Connexin36 (Cx36) contributes to pancreatic β-cell function. We have recently demonstrated that Cx36 also supports β-cell survival by a still unclear mechanism...
  11. doi Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ
    Jacques Antoine Haefliger
    Service of Internal Medicine, Department of Physiology, University Hospital Lausanne, Lausanne, Switzerland
    J Mol Endocrinol 51:49-58. 2013
    ..continuous glucose infusion in adult rats, we showed that prolonged (24-48 h) hyperglycemia reduced the Cx36 gene Gjd2 mRNA levels in pancreatic islets...
  12. pmc High-resolution proteomic mapping in the vertebrate central nervous system: close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1)
    J E Rash
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA
    J Neurocytol 33:131-51. 2004
    ..1-0.3 microm) to neuronal gap junctions labeled for Cx35, which is the fish ortholog of connexin36 (Cx36) found at neuronal gap junctions in mammals...
  13. pmc Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina
    C Ciolofan
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 3J7
    Neuroscience 140:433-51. 2006
    ....
  14. doi Differential expression of hippocampal connexins after acute hypoxia in the developing brain
    Michele P Zeinieh
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Brain Dev 32:810-7. 2010
    ..b>Cx36 protein levels transiently decreased at P11 after acute hypoxia then returned to control levels...
  15. pmc Evidence for connexin36 localization at hippocampal mossy fiber terminals suggesting mixed chemical/electrical transmission by granule cells
    James I Nagy
    Department of Physiology, Faculty of Medicine, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E 0J9
    Brain Res 1487:107-22. 2012
    ..between dendrites of parvalbumin-positive interneurons, a high density of fine, punctate immunolabeling for Cx36, non-overlapping with parvalbumin, was found in subregions of the stratum lucidum in the ventral hippocampus of rat ..
  16. doi Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain
    Javier Franco-Pérez
    Department of Neurophysiology, National Institute of Neurology and Neurosurgery, National Autonomous University of Mexico, Mexico DF, Mexico
    Neuroreport 23:103-7. 2012
    ....
  17. pmc Connexin 36 expression regulates neuronal differentiation from neural progenitor cells
    Elizabeth M Hartfield
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e14746. 2011
    ..b>Connexin 36 (Cx36) is expressed extensively in the developing brain, with levels peaking at P14 after which its levels fall ..
  18. ncbi The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development
    G Sohl
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Germany
    FEBS Lett 428:27-31. 1998
    ..Connexin36 mRNA (2.9 kb) is highly expressed in adult retina and less abundant in brain where it gradually increased during fetal development until day 7 post partum, and decreased thereafter...
  19. pmc Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord
    J E Rash
    Department of Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    Cell Commun Adhes 8:315-20. 2001
    We have identified cells expressing Cx26, Cx30, Cx32, Cx36 and Cx43 in gap junctions of rat central nervous system (CNS) using confocal light microscopic immunocytochemistry and freeze-fracture replica immunogold labeling (FRIL)...
  20. ncbi Cx36 and the function of endocrine pancreas
    A Calabrese
    Department of Morphology, University of Geneva, Geneve, Switzerland
    Cell Commun Adhes 8:387-91. 2001
    ..The insulin-producing beta-cells, which form the bulk of endocrine pancreatic islets, express predominantly Cx36. To assess the function of this connexin, we have first studied its expression in rats, during sequential changes ..
  21. ncbi Connexin-36 contributes to control function of insulin-producing cells
    Sabine Le Gurun
    Department of Internal Medicine, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Biol Chem 278:37690-7. 2003
    Connexin-36 (Cx36) is a gap junction protein expressed by the insulin-producing beta-cells...
  22. ncbi Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines
    David Martin
    Department of Internal Medicine, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Biol Chem 278:53082-9. 2003
    Connexin36 (Cx36) is specifically expressed in neurons and in pancreatic beta-cells. Cx36 functions as a critical regulator of insulin secretion and content in beta-cells...
  23. ncbi Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells
    Daniele F Condorelli
    Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, University of Catania, Catania, Italy
    Eur J Neurosci 18:1807-27. 2003
    ..immunohistochemical detection for neuronal markers, we provide evidence that, among cerebral connexins (Cx26, Cx32, Cx36, Cx37, Cx40, Cx43, Cx45 and Cx47), only Cx45 and Cx36 mRNAs are localized in neuronal cells in both developing and ..
  24. ncbi Expression of gap junction connexin36 in adult rat retinal ganglion cells
    Soh Hidaka
    Department of Physiology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192 Japan
    J Integr Neurosci 1:3-22. 2002
    ..A member of gap junction channel subunit connexin36 (Cx36), is probed for the location of cell-to-cell communication in the mammalian retina, where gap junction networks of ..
  25. ncbi Extended cocaine self-administration and deprivation produces region-specific and time-dependent changes in connexin36 expression in rat brain
    Clinton B McCracken
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 58:141-50. 2005
    ..These results suggest that changes in neuronal gap junction expression may be one mechanism by which cocaine self-administration produces enduring changes in behavior...
  26. ncbi Glucose represses connexin36 in insulin-secreting cells
    Florent Allagnat
    Department of Internal Medicine, Laboratory of Molecular Biology 19 135S, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Cell Sci 118:5335-44. 2005
    The gap-junction protein connexin36 (Cx36) contributes to control the functions of insulin-producing cells. In this study, we investigated whether the expression of Cx36 is regulated by glucose in insulin-producing cells...
  27. doi Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets
    C P F Carvalho
    Department of Histology and Embryology, Institute of Biology, University of Campinas UNICAMP, Campinas, Sao Paulo, CEP 13083 970, Brazil
    Diabetologia 53:1428-37. 2010
    ..We investigated the cellular production and localisation of CX36 and CX43, and gap junction-mediated beta cell coupling in pancreatic islets from rats of different ages, displaying ..
  28. doi Changes in hippocampal connexin 36 mRNA and protein levels during epileptogenesis in the kindling model of epilepsy
    Siamak Beheshti
    Department of Animal Biology, School of Biology, University College of Science, Tehran University, Tehran, Iran
    Prog Neuropsychopharmacol Biol Psychiatry 34:510-5. 2010
    ..One of the main brain regions involved in epileptogenesis is the hippocampus in which there is a network of gap junctional communication between different cell types...
  29. pmc Dopamine-stimulated dephosphorylation of connexin 36 mediates AII amacrine cell uncoupling
    W Wade Kothmann
    Richard S Ruiz Department of Ophthalmology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Neurosci 29:14903-11. 2009
    ..These electrical synapses are widespread in the CNS and serve a variety of important functions. In the retina, connexin 36 (Cx36) gap junctions couple AII amacrine cells and are a requisite component of the high-sensitivity rod ..
  30. doi Loss of connexin36 in rat hippocampus and cerebellar cortex in persistent Borna disease virus infection
    Christiane Köster-Patzlaff
    Center of Anatomy, University of Gottingen, Kreuzbergring 36, 37075 Gottingen, Germany
    J Chem Neuroanat 37:118-27. 2009
    ..of electrical synapses, and we, therefore, analysed expression of the neuronal gap junction protein connexin36 (Cx36) in the Lewis rat hippocampal formation, and cerebellar cortex, 4 and 8 weeks after neonatal infection...
  31. pmc Immunohistochemical detection of connexin36 in sympathetic preganglionic and somatic motoneurons in the adult rat
    Nephtali Marina
    Department of Physiology, University College London, London, WC1 E6BT, UK
    Auton Neurosci 139:15-23. 2008
    ..Gap junctions in the adult spinal cord are constituted principally by connexin36 (Cx36). However, the distribution of Cx36 in specific neuronal populations of the spinal cord is unknown...
  32. doi ATP release by way of connexin 36 hemichannels mediates ischemic tolerance in vitro
    Sarah C Schock
    Department of Cellular and Molecular Medicine, University of Ottawa, Ont, Canada
    Biochem Biophys Res Commun 368:138-44. 2008
    ..Knockdown of connexin 36 expression by siRNA greatly reduces the amount of ATP released during depolarization and the subsequent degree ..
  33. ncbi ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells
    Florent Allagnat
    Department of Medicine, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Biol Chem 283:5226-34. 2008
    Channels formed by the gap junction protein connexin36 (Cx36) contribute to the proper control of insulin secretion. We investigated the impact of chronic hyperlipidemia on Cx36 expression in pancreatic beta-cells...
  34. pmc Identification of connexin36 in gap junctions between neurons in rodent locus coeruleus
    J E Rash
    Department of Biomedical Sciences, Colorado State University, Campus Delivery 1617, Fort Collins, CO 80523, USA
    Neuroscience 147:938-56. 2007
    ..In early postnatal development, connexin36 (Cx36) and connexin43 (Cx43) immunofluorescent puncta were densely distributed in the locus coeruleus, whereas Cx32 and ..
  35. ncbi Immunoreactivity for the GABAA receptor alpha1 subunit, somatostatin and Connexin36 distinguishes axoaxonic, basket, and bistratified interneurons of the rat hippocampus
    Agnes Baude
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, UK
    Cereb Cortex 17:2094-107. 2007
    ..The differential expression of signaling molecules and the relative frequency of cells reflect the specialized temporal contribution of the 3 types of PV-positive interneurons to GABA release in the network...
  36. ncbi The connexin 36 blockers quinine, quinidine and mefloquine inhibit cortical spreading depression in a rat neocortical slice model in vitro
    Doru Georg Margineanu
    UCB S A, CNS Research, B 1420 Braine l Alleud, Belgium
    Brain Res Bull 71:23-8. 2006
    ..to settle whether SD inhibition in vitro by quinine, quinidine and mefloquine reflects an involvement of neuronal Cx36 channels in SD generation/propagation, these results bear potential drug-discovery relevance for the migraine with ..

Research Grants4

  1. Zeiss LSM 510 Laser Scanning Microscope
    JOHN RASH; Fiscal Year: 2002
    ..The DIC Board of Directors will meet bi-monthly to insure continued efficient scheduling and operation of the replacement confocal microscope, to consider future upgrades, and to establish or change DIC access policies. ..
  2. Gap Junctions and Connexins in Developing CNS
    JOHN RASH; Fiscal Year: 2005
    ....
  3. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    JOHN RASH; Fiscal Year: 2007
    ..abstract_text> ..