Gria2

Summary

Gene Symbol: Gria2
Description: glutamate ionotropic receptor AMPA type subunit 2
Alias: GluA2, GluR-K2, GluR2, gluR-B, glutamate receptor 2, AMPA-selective glutamate receptor 2, glutamate receptor B, glutamate receptor, ionotropic, AMPA 2
Species: rat

Top Publications

  1. ncbi Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites
    Baosong Liu
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:5309-19. 2006
  2. doi Protein interacting with C kinase 1 (PICK1) and GluR2 are associated with presynaptic plasma membrane and vesicles in hippocampal excitatory synapses
    C Haglerød
    Institute of Basic Medical Sciences, Department of Anatomy, and Centre for Molecular Biology and Neuroscience, University of Oslo, P O Box 1105 Blindern, 0317 Oslo, Norway
    Neuroscience 158:242-52. 2009
  3. ncbi Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
    B Sommer
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, F R G
    Science 249:1580-5. 1990
  4. ncbi Control of kinetic properties of AMPA receptor channels by nuclear RNA editing
    H Lomeli
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Germany
    Science 266:1709-13. 1994
  5. ncbi GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
    H Dong
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 386:279-84. 1997
  6. ncbi Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements
    S J Myers
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 18:6723-39. 1998
  7. ncbi GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex
    B Ye
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 26:603-17. 2000
  8. ncbi Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
    S Shi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 105:331-43. 2001
  9. ncbi Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting
    Michael Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 34:39-52. 2002
  10. ncbi Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons
    Mako Narisawa-Saito
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 277:40901-10. 2002

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites
    Baosong Liu
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:5309-19. 2006
    ..Ischemic insults promote internalization of glutamate receptor subunit 2 (GluR2)-containing AMPARs from synaptic sites via clathrin-dependent endocytosis and facilitate delivery of GluR2-lacking ..
  2. doi Protein interacting with C kinase 1 (PICK1) and GluR2 are associated with presynaptic plasma membrane and vesicles in hippocampal excitatory synapses
    C Haglerød
    Institute of Basic Medical Sciences, Department of Anatomy, and Centre for Molecular Biology and Neuroscience, University of Oslo, P O Box 1105 Blindern, 0317 Oslo, Norway
    Neuroscience 158:242-52. 2009
    ..Subfractionation and high-resolution immunogold analyses of the rat hippocampus revealed that GluR2 and PICK1 are enriched postsynaptically, but also in presynaptic membrane compartments, including the active zone ..
  3. ncbi Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
    B Sommer
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, F R G
    Science 249:1580-5. 1990
    ..These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing...
  4. ncbi Control of kinetic properties of AMPA receptor channels by nuclear RNA editing
    H Lomeli
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Germany
    Science 266:1709-13. 1994
    ..The extent of editing at this site progresses with brain development in a manner specific for subunit and splice form, and edited channels possess faster recovery rates from desensitization...
  5. ncbi GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
    H Dong
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 386:279-84. 1997
    ..GRIP appears to serve as an adapter protein that links AMPA receptors to other proteins and may be critical for the clustering of AMPA receptors at excitatory synapses in the brain...
  6. ncbi Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements
    S J Myers
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 18:6723-39. 1998
    To understand how neurons control the expression of the AMPA receptor subunit GluR2, we cloned the 5' proximal region of the rat gene and investigated GluR2 promoter activity by transient transfection...
  7. ncbi GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex
    B Ye
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 26:603-17. 2000
    ..These results suggest that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity...
  8. ncbi Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
    S Shi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 105:331-43. 2001
    ..In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms...
  9. ncbi Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting
    Michael Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 34:39-52. 2002
    ..Thus, by mediating the targeting of liprin/GRIP-associated proteins, liprin-alpha is important for postsynaptic as well as presynaptic maturation...
  10. ncbi Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons
    Mako Narisawa-Saito
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 277:40901-10. 2002
    ..After the single transfection of GluR2 cDNA or GluR1 cDNA into HEK/TrkB cells, BDNF triggered the translocation of GluR2 but not that of GluR1...
  11. ncbi Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus
    Yunfei Huang
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 22:8422-8. 2002
    ..assay, we found that acetylation of histone H4 in rat hippocampal CA3 neurons was reduced at the glutamate receptor 2 (GluR2; GRIA2) glutamate receptor promoter but increased at brain-derived neurotrophic factor promoter P2 ..
  12. ncbi Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells
    Kenneth J Seidenman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 23:9220-8. 2003
    ..The glutamate receptor subunit 2 (GluR2) PDZ ligand domain can be phosphorylated at serine 880 (S880), and this disrupts interactions with GRIP/ABP (..
  13. pmc Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD
    Gholamreza Ahmadian
    National Research Center for Genetic Engineering and Biotechnology, Tehran, Iran
    EMBO J 23:1040-50. 2004
    ..In HEK293 cells transiently expressing GluR1 or GluR2 mutants containing domain deletions or point mutations in their intracellular carboxyl termini (CT), we found that ..
  14. ncbi LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses
    Anthone W Dunah
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 8:458-67. 2005
    ..Cadherin, beta-catenin and GluR2/3 are tyrosine phosphoproteins that coimmunoprecipitate with liprin-alpha and GRIP from rat brain extracts...
  15. ncbi PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
    Wei Lu
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:407-21. 2005
    PICK1 and ABP/GRIP bind to the AMPA receptor (AMPAR) GluR2 subunit C terminus. Transfer of the receptor from ABP/GRIP to PICK1, facilitated by GluR2 S880 phosphorylation, may initiate receptor trafficking...
  16. pmc Long-term potentiation of exogenous glutamate responses at single dendritic spines
    Ashish A Bagal
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 102:14434-9. 2005
    ..These changes are consistent with an increase in the proportion of GluR2-containing AMPARs in the spine head...
  17. ncbi Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation
    Hillel Adesnik
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:4598-602. 2007
    ..Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained...
  18. doi N-ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation
    Tayo Katano
    Department of Medical Chemistry, Kansai Medical University, Moriguchi 570 8506, Japan
    Eur J Neurosci 27:3161-70. 2008
    ..Concomitant with the decrease in NSF, GluR2 and GluR3 were decreased and GluR1 was conversely increased in the PSD fraction 24 h after CFA injection...
  19. pmc Numbers, densities, and colocalization of AMPA- and NMDA-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats
    Miklos Antal
    Department of Anatomy, Histology, and Embryology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, H 4012 Debrecen, Hungary
    J Neurosci 28:9692-701. 2008
    ..Virtually all (99%) glutamatergic postsynaptic membranes expressed GluR2, and most of them (87%) were also immunoreactive for GluR1...
  20. doi Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors
    Jochen Schwenk
    Institute of Physiology II, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany
    Science 323:1313-9. 2009
    ..These results demonstrate that cornichons are intrinsic auxiliary subunits of native AMPARs and provide previously unknown molecular determinants for glutamatergic neurotransmission in the central nervous system...
  21. pmc Crystal structure and association behaviour of the GluR2 amino-terminal domain
    Rongsheng Jin
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA, USA
    EMBO J 28:1812-23. 2009
    ..Here we show that AMPA receptor GluR1- and GluR2-ATDs form tightly associated dimers and, by the analysis of crystal structures of the GluR2-ATD, propose ..
  22. pmc X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
    Alexander I Sobolevsky
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nature 462:745-56. 2009
    ..structure of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive, homotetrameric, rat GluA2 receptor at 3.6 A resolution in complex with a competitive antagonist...
  23. ncbi Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
    J W Lin
    Howard Hughes Medical Institute, Massachusetts General Hospital Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 3:1282-90. 2000
    ..dependent on protein phosphatases and sequence determinants within the cytoplasmic tails of GluR1 and GluR2 subunits...
  24. ncbi Effects of single or repeated restraint stress on GluR1 and GluR2 flip and flop mRNA expression in the hippocampal formation
    Maria Luiza Nunes Mamede Rosa
    Department of Physiology, FORP University of São Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Brain Res Bull 59:117-24. 2002
    ..The GluR1 flip mRNA was slightly reduced in CA1 after chronic stress and the GluR2 flip mRNA was increased in the dentate gyrus (DG), CA4, and CA3 after acute stress...
  25. ncbi Inhibition of glutamate receptor 2 translation by a polymorphic repeat sequence in the 5'-untranslated leaders
    Scott J Myers
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 24:3489-99. 2004
    Previous studies have identified multiple transcription initiation sites for the glutamate receptor 2 (GluR2) gene, resulting in a heterogeneous population of GluR2 transcripts in vivo that differ in the length of their 5'-untranslated ..
  26. ncbi Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicity
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:36004-11. 2006
    ..Ca2+ permeability of AMPARs is inversely correlated with the abundance of the AMPAR subunit glutamate receptor 2 (GluR2)...
  27. ncbi LTP inhibits LTD in the hippocampus via regulation of GSK3beta
    Stephane Peineau
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
    Neuron 53:703-17. 2007
    ..We conclude that the regulation of GSK3beta activity provides a powerful mechanism to preserve information encoded during LTP from erasure by subsequent LTD, perhaps thereby permitting the initial consolidation of learnt information...
  28. pmc A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha
    Bryony A Dickinson
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Mol Brain 2:18. 2009
    ..However, we find a distinct mechanism of LTD involving GRIP and liprin-alpha...
  29. doi The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells
    Francesca Beretta
    DTI Dulbecco Telethon Institute, Via Vanvitelli 32, Milan 20129, Italy
    Eur J Neurosci 30:25-34. 2009
    ..We found that GluR2 is absent in fast-growing GBM-derived tumour stem cells and high-grade glioma specimens, but is expressed in slow-..
  30. doi PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma
    J D Bell
    Cara Phelan Centre for Trauma Research and Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada M5B1W8
    Cell Death Differ 16:1665-80. 2009
    Constitutive and activity-dependent regulation of the AMPA receptor GluR2 content is recognized as an important mediator of both neuronal plasticity and vulnerability to excitotoxic neuron death...
  31. pmc On the mechanisms of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor binding to glutamate and kainate
    Michael K Fenwick
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 285:12334-43. 2010
    ..binding of glutamate and kainate (full and partial agonists, respectively) to a soluble ligand-binding domain of GluR2. Our results provide a structural basis for sequential state models of agonist binding and the free energy changes ..
  32. pmc Perisynaptic GluR2-lacking AMPA receptors control the reversibility of synaptic and spines modifications
    Yunlei Yang
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:11999-2004. 2010
    ..Here, we report that perisynaptic AMPARs are GluR2-lacking and they translocate to synapses in a protein kinase C (PKC)-dependent manner...
  33. doi Interaction between N-ethylmaleimide-sensitive factor and GluR2 is essential for fear memory formation in lateral amygdala
    Gil Joels
    Department of Neurobiology and Ethology and Biology, University of Haifa, Haifa, Israel
    J Neurosci 30:15981-6. 2010
    ..that GluR1-containing AMPA receptors are inserted into synapses following stimuli leading to plasticity and that GluR2/GluR3-containing receptors replace existing synaptic AMPA receptors continuously and may act to maintain synaptic ..
  34. pmc Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability
    Fadi F Hamdan
    Centre of Excellence in Neuromics of Université de Montréal, Sainte Justine Hospital Research Centre, Montreal, Canada
    Am J Hum Genet 88:306-16. 2011
    ..None of these mutations or any other DNMs were identified in these genes in 285 healthy controls. This study highlights the importance of the glutamate receptor complexes in NSID and further supports the role of DNMs in this disorder...
  35. doi Molecular dynamics simulations for glutamate-binding and cleft-closing processes of the ligand-binding domain of GluR2
    Okimasa Okada
    ZoeGene Corporation, Yokohama, Kanagawa, Japan
    Biophys Chem 162:35-44. 2012
    ..channel of ionotropic glutamate receptors is controlled by the structural change of the ligand-binding domain of GluR2. We examined the roles of residues in the glutamate-binding and cleft-closing mechanisms by molecular dynamics (MD)..
  36. pmc The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2
    Ahmed H Ahmed
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 287:41007-13. 2012
    ..The structure of kaitocephalin bound to the ligand binding domain of the AMPA receptor subtype, GluA2, is reported here...
  37. pmc Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain
    Andrew C Penn
    Neurobiology Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Neuron 76:503-10. 2012
    ..AMPAR mRNA indeed exhibited reprogramming of the flip/flop exons for GluA1 and GluA2 subunits in response to activity, selectively in the CA1 subfield...
  38. doi Hypoxia-induced retinal ganglion cell damage through activation of AMPA receptors and the neuroprotective effects of DNQX
    V Sivakumar
    Department of Anatomy, Yong Loo Lin School of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore 117597, Singapore
    Exp Eye Res 109:83-97. 2013
    ..The involvement of AMPA receptors in damaging the RGCs is evidenced by suppression of intracellular Ca(2+) influx by DNQX which also decreased ROS generation and cell death by 50%...
  39. ncbi Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death
    Keishi Ishida
    Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
    J Toxicol Sci 38:513-21. 2013
    Lead is known to induce neurotoxicity, particularly in young children, and GluR2, an AMPA-type glutamate receptor subunit, plays an important role in neuronal cell survival...
  40. pmc Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms
    Shao Rui Chen
    Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas S R C, H Y Z, H S B, H L P Graduate Program in Neuroscience, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas H L P
    J Pharmacol Exp Ther 347:765-72. 2013
    ..AMPARs lacking the GluA2 subunit are permeable to Ca(2+), and their currents show unique inward rectification...
  41. pmc O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses
    Erica W Taylor
    Department of Cell, Developmental and Integrative Biology, Department of Neurology, Department of Psychiatry and Behavioral Neurobiology, and Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Neurosci 34:10-21. 2014
    Serine phosphorylation of AMPA receptor (AMPAR) subunits GluA1 and GluA2 modulates AMPAR trafficking during long-term changes in strength of hippocampal excitatory transmission required for normal learning and memory...
  42. doi Dorsal hippocampal brain receptor complexes linked to the protein synthesis-dependent late phase (LTP) in the rat
    Lin Li
    Department of Pediatrics, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Brain Struct Funct 220:1051-62. 2015
    ..gel electrophoresis and immunoprecipitation followed by mass spectrometrical identification of the NR1-GluA1-GluA2 complex was used to provide evidence for complex formation...
  43. doi L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain
    Christian Krintel
    Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    FEBS J 281:2422-30. 2014
    In purification of the ionotropic glutamate receptor A2 (GluA2) ligand-binding domain (LBD), L-Glu-supplemented buffers have previously been used for protein stabilization during the procedure...
  44. pmc Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states
    Katharina L Dürr
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Cell 158:778-92. 2014
    ..Here, we elucidate the structures of the intact GluA2 AMPA receptor in an apo resting/closed state, in an activated/pre-open state bound with partial agonists and a ..
  45. ncbi The structure and function of glutamate receptor ion channels
    Dean R Madden
    Ion Channel Structure Research Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nat Rev Neurosci 3:91-101. 2002
    ....
  46. ncbi Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:6578-89. 2004
    ....
  47. ncbi Differential regulation of AMPA receptor trafficking by neurabin-targeted synaptic protein phosphatase-1 in synaptic transmission and long-term depression in hippocampus
    Xiao Dong Hu
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 27:4674-86. 2007
    ..which is correlated with the reduction in surface expression of AMPA subtype glutamate receptor (GluR) 1 and GluR2 subunits...
  48. ncbi [The expressions and distribution characters of glutamate receptor subunits NR1 and GluR2 in the hippocampal formation of adult rats]
    Li Zhang
    Department of Physiology and Pathophysiology, Medical School of Xi an Jiaotong University, Xi an 710061, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 39:15-8. 2008
    To investigate the expressions and distributions of N-methyl-D-aspartic acid NMDA/ NR1 and alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid AMPA/GluR2 subunits in the hippocampal formation.
  49. pmc Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits
    Andrew J Todd
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Eur J Neurosci 29:718-26. 2009
    ..All AMPAr-positive synapses in spinal cord are thought to contain GluR2, while the other subunits have specific laminar distributions...
  50. doi Subunit-selective palmitoylation regulates the intracellular trafficking of AMPA receptor
    Guang Yang
    Graduate Program of Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada
    Eur J Neurosci 30:35-46. 2009
    The AMPA receptor (AMPAR) subunits GluR1 and GluR2 show different properties in central neurons and affect AMPAR trafficking via distinct mechanisms...
  51. doi Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization
    Xin Shao
    Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of Medicine, 388 Yu Hang Tang Road, Hangzhou, Zhejiang 310058, China
    Neurochem Int 56:962-70. 2010
    ..co-immunoprecipitation experiments to confirm that T82 was indeed critical for the interaction between PICK1 and GluR2. In addition, T82E mutation mimicking the phosphorylation of PICK1 dispersed the colocalization of PICK1 and GluR2 ..
  52. pmc Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons
    Reuben Saba
    Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universitat Heidelberg, and Institut für Neuroanatomie, Universitatsklinikum, Heidelberg, Heidelberg, Germany
    Mol Cell Biol 32:619-32. 2012
    ..Using bioinformatics tools, we detected a highly conserved miR-181a binding site within the mRNA encoding the GluA2 subunit of AMPA-Rs...
  53. pmc Calcium-permeable AMPA receptors provide a common mechanism for LTP in glutamatergic synapses of distinct hippocampal interneuron types
    Andras Szabo
    Department of Pharmacology, Oxford University, Oxford OX1 3QT, United Kingdom
    J Neurosci 32:6511-6. 2012
    ..The strong inward rectification and calcium permeability of AMPARs is explained by a low level of GluA2 subunit mRNA expression...
  54. pmc Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L
    Natalie F Shanks
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Rep 1:590-8. 2012
    ..GSG1L extends the functional variety of AMPA-R complexes, and further investigation of other candidates may reveal additional complexity of ionotropic glutamate receptor function...
  55. pmc Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission
    Marc P Lussier
    Receptor Biology Section and Biochemistry Section Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:19426-31. 2012
    ..Therefore, our study identifies RNF167 as a selective regulator of AMPAR-mediated neurotransmission and expands our understanding of how ubiquitination dynamically regulates excitatory synapses...
  56. pmc SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons
    Nadia Jaafari
    School of Biochemistry, University of Bristol, Bristol, United Kingdom
    PLoS ONE 8:e52345. 2013
    ..Taken together these data demonstrate that SUMOylation of synaptic protein(s) involved in AMPA receptor trafficking is necessary for activity-dependent increases in AMPAR surface expression...
  57. pmc Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression
    Hussam Jourdi
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 8:e57124. 2013
    ..Our results show that acute BDNF treatment upregulates the interactions between AMPAr subunits (GluR1 and GluR2) with their scaffold proteins SAP97 and GRIP1, respectively, leading to prolonged increased accumulation of both ..
  58. pmc A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties
    N Nakanishi
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Neuron 5:569-81. 1990
    ..These observations indicate that the kainate/quisqualate receptors are encoded by a family of genes and are likely to be composed of hetero-oligomers of at least two distinct subunits...
  59. ncbi A family of AMPA-selective glutamate receptors
    K Keinanen
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, F R G
    Science 249:556-60. 1990
    ....
  60. ncbi Molecular cloning and functional expression of glutamate receptor subunit genes
    J Boulter
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138
    Science 249:1033-7. 1990
    Three closely related genes, GluR1, GluR2, and GluR3, encode receptor subunits for the excitatory neurotransmitter glutamate...
  61. ncbi The organization of the gene for the functionally dominant alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluR-B
    M Kohler
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Federal Republic of Germany
    J Biol Chem 269:17367-70. 1994
    ..The major GluR-B mRNAs in murine brain, 4 and 6 kilobase differ in the length of their 3'-untranslated region...
  62. ncbi Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP
    S Srivastava
    Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical Center, New York 10016, USA
    Neuron 21:581-91. 1998
    ..related to glutamate receptor-interacting protein (GRIP) with two sets of three PDZ domains, which binds the GluR2/3 AMPA receptor subunits. ABP exhibits widespread CNS expression and is found at the postsynaptic membrane...
  63. ncbi Structure of a glutamate-receptor ligand-binding core in complex with kainate
    N Armstrong
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nature 395:913-7. 1998
    ..The structure indicates mechanisms for allosteric effector action and for ligand-induced channel gating. The information provided by this structure will be essential in designing new ligands...
  64. ncbi rDLG6: a novel homolog of Drosophila DLG expressed in rat brain
    H Inagaki
    Department of Chemistry, National Industrial Research Institute of Nagoya, 1 1 Hirate cho, Kita ku, Nagoya, 462 8510, Japan
    Biochem Biophys Res Commun 265:462-8. 1999
    ..GST pull-down assays showed that the PDZ domain of rDLG6 protein binds to the C-terminus of the AMPA (alpha-Amino-3-hydroxy-5-Methyl-isoxazole-4-Propionic Acid) receptor GluR2 subunit.
  65. pmc A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing
    P J Aruscavage
    Department of Biochemistry Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA
    RNA 6:257-69. 2000
    ..The approximately 600-nt intron 13 of gluR-C was particularly remarkable, showing >94% nucleotide identity between human and chicken, organisms estimated to have diverged 310 million years ago...
  66. ncbi The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway
    Tomoyuki Nishizaki
    Department of Physiology, Hyogo College of Medicine, 1 1 Mukogawa cho, 663 8501, Nishinomiya, Japan
    Brain Res Mol Brain Res 98:130-4. 2002
    ..acid (AMPA) receptors, heteromerically formed of GluR1,2 (GluR1 and GluR2), GluR1,3 (GluR1 and GluR3), and GluR1,2,3 (GluR1, GluR2, and GluR3), expressed in Xenopus oocytes...
  67. ncbi Co-localization of AMPA receptor subunits in the nucleus of the solitary tract in the rat
    Sue A Aicher
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Brain Res 958:454-8. 2002
    ..b>GluR2/3 was found at pre- and postsynaptic sites, and in astrocytic glia; while GluR1 was found primarily in small ..
  68. ncbi Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour
    Michael A Sutton
    Division of Molecular Psychiatry and the Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 421:70-5. 2003
    ..during withdrawal from chronic cocaine self-administration induces experience-dependent increases in the GluR1 and GluR2/3 subunits of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) glutamate receptors in the nucleus ..
  69. pmc Characterization of the intracellular transport of GluR1 and GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons
    Pavel V Perestenko
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:43525-32. 2003
    ..Here, using virally expressed green fluorescent protein (GFP)-GluR1 and GFP-GluR2 and confocal photobleach techniques we show near real-time movement of these subunits in living cultured ..
  70. ncbi Ischemia-induced alterations of AMPA-type glutamate receptor subunit. Expression patterns in the rat retina--an immunocytochemical study
    Frederike Dijk
    Glaucoma Research Group, Netherlands Ophthalmic Research Institute KNAW, Graduate School for the Neurosciences Amsterdam, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Brain Res 997:207-21. 2004
    ..In ischemia-vulnerable hippocampal neurons, a subunit-specific downregulation of GluR2 precedes the actual neurodegeneration...
  71. ncbi A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1
    Kogo Takamiya
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 36:172-7. 2004
    ..Our data indicate that GRIP1 is required for normal cell-matrix interactions during early embryonic development and that inactivation of Grip1 causes Fraser syndrome-like defects in mice...
  72. ncbi Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons
    Sang Hyoung Lee
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 43:221-36. 2004
    ..The intracellular accumulation of GluR2 and GluR3 but not GluR1 is enhanced by AMPA, NMDA, or synaptic activity...
  73. ncbi Predominant expression of GluR2 among the AMPA receptor subunits in neuronal progenitor cells of the rat hippocampus
    Norikazu Hagimura
    Department of Neurophysiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi 371 8511, Japan
    Brain Res Dev Brain Res 152:213-23. 2004
    ..of the AMPA-induced current was slightly outwardly rectifying, suggesting that the AMPA receptors contained the GluR2 subunit in their oligomeric assemblies...
  74. ncbi S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors
    Yunfei Huang
    Department of Neuroscience, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Neuron 46:533-40. 2005
    ..S-nitrosylation of NSF augments its binding to the AMPAR GluR2 subunit...
  75. pmc Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2
    Pascal Steiner
    Brain Mind Institute, Faculté des Sciences de la Vie, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    EMBO J 24:2873-84. 2005
    ..for receptor recycling including AMPAR, is associated with the scaffolding protein GRIP1 and the AMPAR subunit GluR2. Moreover, the interaction between NEEP21 and GRIP1 is regulated by neuronal activity...
  76. ncbi A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study
    Mai Marie Holm
    Department of Molecular Biology, C F Møllers Allé Bldg 130, University of Aarhus, DK 8000 Aarhus, Denmark
    J Biol Chem 280:35469-76. 2005
    ..The AMPA receptor GluR2, with mutations in Tyr-450, were expressed in Xenopus laevis oocytes and characterized in a two-electrode voltage ..
  77. ncbi The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209
    Christina Kasper
    Biostructural Research Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Mol Biol 357:1184-201. 2006
    ..We present here the first X-ray structure of a mixed GluR2 ligand-binding core dimer, with the high-affinity antagonist (S)-8-methyl-5-(4-(N,N-dimethylsulfamoyl)phenyl)-6,7,..
  78. pmc Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines
    Jason J Radley
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1134:87-94. 2007
    ..a quantitative analysis for alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits GluR2 and GluR3 and N-methyl-D-aspartate (NMDA) receptor subunits NR1 and NR2B by combining anterograde labeling of ..
  79. pmc NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2
    Jonathan G Hanley
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    J Neurochem 101:1644-50. 2007
    ..NSF binds AMPAR subunit glutamate receptor subunit 2 (GluR2) and functions to maintain receptors at the synapse...
  80. pmc Differential localization of the GluR1 and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats
    Y P Deng
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Chem Neuroanat 33:167-92. 2007
    ..We therefore used immunolabeling to assess the frequency and abundance of GluR1 and GluR2, the most common AMPA subunits in striatum, in the main striatal neuron types...
  81. ncbi Early music exposure modifies GluR2 protein expression in rat auditory cortex and anterior cingulate cortex
    Feng Xu
    College of Life Sciences, Institute of Cognitive Neuroscience, East China Normal University, Shanghai 200062, China
    Neurosci Lett 420:179-83. 2007
    b>GluR2, a major subunit in AMPA receptor, plays an important role in brain functional activity...
  82. pmc Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
    ..The Ca(2+) permeability of AMPA receptors is largely determined by the glutamate receptor 2 (GluR2) subunit, receptors lacking GluR2 being permeable to Ca(2+) ions...
  83. pmc Surface mobility of postsynaptic AMPARs tunes synaptic transmission
    Martin Heine
    CNRS, UMR 5091, Universite Bordeaux, Bordeaux, France
    Science 320:201-5. 2008
    ..Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses...
  84. doi Colocalisation of serotonin2A receptors with the glutamate receptor subunits NR1 and GluR2 in the dentate gyrus: an ultrastructural study of a modulatory role
    C J Peddie
    Department of Life Sciences, The Open University, Milton Keynes, MK7 6AA, UK
    Exp Neurol 211:561-73. 2008
    ..NMDA) and amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor subunits NR1 and GluR2 in the hippocampal dentate gyrus (DG) in order to investigate whether 5-HT(2A)R location is compatible with a ..
  85. pmc AMPA and NMDA glutamate receptors are found in both peptidergic and non-peptidergic primary afferent neurons in the rat
    Helen Willcockson
    Department of Cell and Developmental Biology, University of North Carolina, CB 7090, Chapel Hill, NC 27599, USA
    Cell Tissue Res 334:17-23. 2008
    ..the NR1 subunit of the NMDA receptor (40%) was significantly higher than that of DRG neurons immunostained for the GluR2/3 (27%) or the GluR4 (34%) subunits of the AMPA receptor...
  86. doi A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory
    B Altinbilek
    Department of Experimental Neurophysiology, Medical Faculty, Ruhr University Bochum, Universitaetsstrasse 150, FNO 01 116, 44780 Bochum, Germany
    Neuroscience 158:149-58. 2009
    ..These findings support the importance of group II mGluRs for spatial memory formation and offer a further link between LTD and the encoding of spatial information in the hippocampus...
  87. pmc Energetics of the cleft closing transition and the role of electrostatic interactions in conformational rearrangements of the glutamate receptor ligand binding domain
    Tatyana Mamonova
    Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Biochemistry 47:11077-85. 2008
    ..The free energy of the GluR2 S1S2 ligand binding domain (S1S2) closure transition was computed using a combination of thermodynamic integration ..
  88. pmc Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats
    Binbin Yan
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Parkway, Orlando, FL 32816, USA
    Am J Physiol Regul Integr Comp Physiol 296:R299-308. 2009
    ..CIH -238 +/- 27 beats/min, P < 0.05); and 3) the number of NMDAR1, AMPA GluR1, and AMPA GluR2/3-immunoreactive cells in the NA was reduced (P < 0.05)...
  89. pmc Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit
    Julia Brill
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 28:13918-28. 2008
    Many principal neurons undergo an early developmental switch from GluR2-lacking to GluR2-containing synaptic glutamate receptors. We tested the generality and timing of the GluR2 switch in excitatory neurons of rat somatosensory cortex...
  90. doi Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status
    M Majdi
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Room 1325, Montreal, Quebec, Canada H3G 1Y6
    Neuroscience 159:896-907. 2009
    ..was observed in the parietal cortex of AI animals, whereas a significant decrease in AMPA receptor subunit glutamate receptor 2 expression was found in the prefrontal cortex of AI animals...
  91. ncbi [The changes of AMPA receptors subunit GluR2 and mEPSCs in visual cortex of monocular deprivation rats]
    Rui Hao
    Tianjin Medical University, Tianjin Eye Hospital, Tianjin 300020, China
    Zhonghua Yan Ke Za Zhi 44:976-80. 2008
    To observe the change of expression in quantity of AMPA receptor subunit GluR2 and mEPSCs from monocular derivated rats...
  92. pmc Translational regulation of GluR2 mRNAs in rat hippocampus by alternative 3' untranslated regions
    Hasan A Irier
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurochem 109:584-94. 2009
    The glutamate receptor 2 (GluR2) subunit determines many of the functional properties of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate subtype of glutamate receptor...
  93. pmc PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons
    Rebecca M Dixon
    Medical Research Council MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 284:14230-5. 2009
    ..and glucose deprivation (OGD) induces delayed cell death in hippocampal CA1 neurons via Ca(2+)/Zn(2+)-permeable, GluR2-lacking AMPA receptors (AMPARs)...
  94. doi Increased expression of GluR2-flip in the hippocampus of the Wistar audiogenic rat strain after acute and kindled seizures
    Daniel Leite Goes Gitaí
    Department of Cellular and Molecular Biology, Ribeirao Preto School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Hippocampus 20:125-33. 2010
    ..The most represented gene among the 133 clones sequenced was the ionotropic glutamate receptor subunit II (GluR2), a member of the alpha-amino-3-hydroxy-5-methyl-4-isoxazoleopropionic acid (AMPA) receptor...
  95. pmc AMPA receptor ligand binding domain mobility revealed by functional cross linking
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Neurosci 29:11912-23. 2009
    ..Crystallographic, biochemical, and functional studies suggest that GluR2 Cys mutants which form intermolecular disulfide cross-links between the lower D2 lobes of the ligand binding cores ..
  96. doi Alterations in GluR2 AMPA receptor phosphorylation at serine 880 following group I metabotropic glutamate receptor stimulation in the rat dorsal striatum
    Sung Min Ahn
    Department of Biological Sciences, Pusan National University, Pusan, Korea
    J Neurosci Res 88:992-9. 2010
    ..of the group I mGluR agonist, (RS)-3,5-dihydroxyphenylglycine (DHPG, 250 nmol), enhanced the sensitivity of GluR2 subunit in its phosphorylation at serine 880 (S880) in the dorsal striatum...
  97. pmc Hydrophobic side chain dynamics of a glutamate receptor ligand binding domain
    Alexander S Maltsev
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 285:10154-62. 2010
    ..The extracellular ligand binding core (S1S2) of the GluR2 subtype of ionotropic glutamate receptors can be produced as a soluble protein with properties essentially ..
  98. pmc Energy transfer ligands of the GluR2 ligand binding core
    Amy F Petrik
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, Maryland 20892, USA
    Biochemistry 49:2051-7. 2010
    ..We have used an isolated ligand binding domain, GluR2-S1S2J (GluR2), as a model system to study the protein-ligand complex by steady-state and time-resolved intrinsic ..
  99. doi AMPA receptor downregulation induced by ischaemia/reperfusion is attenuated by age and blocked by meloxicam
    S Montori
    Area de Biología Celular, Instituto de Biomedicina Universidad de León, 24071 Leon, Spain
    Neuropathol Appl Neurobiol 36:436-47. 2010
    ..how age and treatment with an anti-inflammatory agent (meloxicam) modify the levels of AMPAR subunits GluR1 and GluR2, as well as the mRNA levels of the GluR2-editing enzyme, ADAR2, in a global brain ischaemia/reperfusion (I/R) model...
  100. doi Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex
    E Ampuero
    Laboratorio de Neurociencias, Universidad de Los Andes, Santiago, Chile
    Neuroscience 169:98-108. 2010
    ..alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit levels (NR1, NR2A, NR2B, GluR1 and GluR2) were analysed in the forebrain by both western blot of homogenates and immunohistochemistry...
  101. pmc Plasma membrane insertion of the AMPA receptor GluA2 subunit is regulated by NSF binding and Q/R editing of the ion pore
    Yoichi Araki
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:11080-5. 2010
    ..To directly visualize fusion events of transport vesicles containing the AMPA receptor GluA2 subunit with the plasma membrane we used pHluorin-tagged GluA2 subunits and total internal reflection fluorescence ..

Research Grants6

  1. Novel pharmacotherapies for treatment of ADHD
    FRANK TARAZI; Fiscal Year: 2003
    ..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
  2. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  3. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
  4. ANATOMICAL STUDIES OF BRAINSTEM CARDIOVASCULAR SYSTEMS
    Sue Aicher; Fiscal Year: 2007
    ..This collaborative project provides a unique opportunity to directly address structural and physiological questions regarding NTS neuronal function in both the normal and hypertensive states. [unreadable] [unreadable]..
  5. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2010
    ..electrophysiologically tagged recombinant AMPA-R-mediated currents, measuring synaptic responses in GluRl and GluR2 knockout mice, as well as quantifying phosphorylated or active endogenous signaling molecules and glutamate ..