Grin2b

Summary

Gene Symbol: Grin2b
Description: glutamate ionotropic receptor NMDA type subunit 2B
Alias: GluN2B, glutamate receptor ionotropic, NMDA 2B, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, glutamate [NMDA] receptor subunit epsilon-2, glutamate receptor, ionotropic, N-methyl D-aspartate 2B, glutamate receptor, ionotropic, NMDA2B
Species: rat

Top Publications

  1. ncbi Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor
    Yasunobu Murata
    Department of Biophysics, Graduate School of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 327:183-91. 2005
  2. pmc Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat
    Kristina S Vikman
    Pain Management Research Institute, Kolling Institute, The University of Sydney at Royal North Shore Hospital, St Leonards NSW 2065, Australia
    J Physiol 586:515-27. 2008
  3. ncbi NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis
    Agata Habas
    Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    J Neurochem 96:335-48. 2006
  4. ncbi Heteromeric NMDA receptors: molecular and functional distinction of subtypes
    H Monyer
    Center for Molecular Biology, University of Heidelberg, Germany
    Science 256:1217-21. 1992
  5. ncbi Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
    H C Kornau
    Center for Molecular Biology ZMBH, University of Heidelberg, Germany
    Science 269:1737-40. 1995
  6. ncbi Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    R V Omkumar
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 271:31670-8. 1996
  7. ncbi Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture
    J H Luo
    Department of Physiology and Biophysics, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, USA
    Neuropharmacology 42:306-18. 2002
  8. pmc NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
    Proc Natl Acad Sci U S A 99:5710-5. 2002
  9. ncbi The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1
    Grigory Krapivinsky
    Howard Hughes Medical Institute, Children s Hospital, 1309 Enders Building, 320 Longwood Avenue, Boston, MA 02115, USA
    Neuron 40:775-84. 2003
  10. ncbi Selective activation induced cleavage of the NR2B subunit by calpain
    Kelly L Simpkins
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4306, USA
    J Neurosci 23:11322-31. 2003

Research Grants

  1. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
  2. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
  3. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
  4. Cell-permeable inibitors specific for CaMKII
    K Ulrich Bayer; Fiscal Year: 2006
  5. CaMKII signaling in insulin secretion and response
    K Ulrich Bayer; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications143 found, 100 shown here

  1. ncbi Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor
    Yasunobu Murata
    Department of Biophysics, Graduate School of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 327:183-91. 2005
    ..In addition, the NMDA receptor subunits, NR1 and NR2B, specifically co-immunoprecipitated with PRR7...
  2. pmc Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat
    Kristina S Vikman
    Pain Management Research Institute, Kolling Institute, The University of Sydney at Royal North Shore Hospital, St Leonards NSW 2065, Australia
    J Physiol 586:515-27. 2008
    ..Furthermore the reduced effectiveness of the NR2B-specific antagonist CP-101,606 on NMDAR-mediated eEPSCs together with a decrease in Mg2+ sensitivity suggests a ..
  3. ncbi NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis
    Agata Habas
    Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    J Neurochem 96:335-48. 2006
    ..b>NR2B-specific NMDAR blockers antagonized anti-apoptotic effects of NMDA, indicating a critical role of NR2B NMDARs in ..
  4. ncbi Heteromeric NMDA receptors: molecular and functional distinction of subtypes
    H Monyer
    Center for Molecular Biology, University of Heidelberg, Germany
    Science 256:1217-21. 1992
    ..cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% identical in sequence...
  5. ncbi Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
    H C Kornau
    Center for Molecular Biology ZMBH, University of Heidelberg, Germany
    Science 269:1737-40. 1995
    ..Transcripts encoding PSD-95 are expressed in a pattern similar to that of NMDA receptors, and the NR2B subunit co-localizes with PSD-95 in cultured rat hippocampal neurons...
  6. ncbi Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    R V Omkumar
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 271:31670-8. 1996
    ..L., and MacDonald, J. F. (1994) Nature 369, 230-232). Here we identify a major phosphorylation site on subunit NR2B that is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (CaM kinase II), an abundant protein kinase ..
  7. ncbi Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture
    J H Luo
    Department of Physiology and Biophysics, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, USA
    Neuropharmacology 42:306-18. 2002
    We generated expression vectors for N-terminally green fluorescent protein -tagged NR2A and NR2B subunits (GFP-NR2A and GFP-NR2B)...
  8. pmc NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
    Proc Natl Acad Sci U S A 99:5710-5. 2002
    ..We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein tyrosine kinase, Fyn...
  9. ncbi The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1
    Grigory Krapivinsky
    Howard Hughes Medical Institute, Children s Hospital, 1309 Enders Building, 320 Longwood Avenue, Boston, MA 02115, USA
    Neuron 40:775-84. 2003
    ..Here we show that NR2B, but not NR2A or NR1 subunits of the NMDAR, interacts in vivo and in vitro with RasGRF1, a Ca(2+)/calmodulin-..
  10. ncbi Selective activation induced cleavage of the NR2B subunit by calpain
    Kelly L Simpkins
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4306, USA
    J Neurosci 23:11322-31. 2003
    ..Subtype-specific antibodies demonstrated that the NR2B subunit was cleaved in these primary cultures, but the NR2A subunit was not...
  11. ncbi Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
    Lidong Liu
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 304:1021-4. 2004
    ..Using hippocampal slice preparations, we showed that selectively blocking NMDARs that contain the NR2B subunit abolishes the induction of LTD but not LTP...
  12. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression
    Peter V Massey
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:7821-8. 2004
    ..We also find that de novo LTD requires the activation of NR2B-containing NMDAR, whereas LTP requires activation of NR2A-containing NMDARs...
  13. ncbi Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    Wei Guo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:9161-73. 2004
    Hindpaw inflammation induces tyrosine phosphorylation (tyr-P) of the NMDA receptor (NMDAR) 2B (NR2B) subunit in the rat spinal dorsal horn that is closely related to the initiation and development of hyperalgesia...
  14. ncbi Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand
    Hee Jung Chung
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:10248-59. 2004
    ..casein kinase II (CK2) phosphorylates the serine residue (Ser1480) within the C-terminal PDZ ligand (IESDV) of the NR2B subunit of NMDAR in vitro and in vivo...
  15. ncbi Synaptic distribution of the NR1, NR2A and NR2B subunits of the N-methyl-d-aspartate receptor in the rat lumbar spinal cord revealed with an antigen-unmasking technique
    Gergely G Nagy
    Spinal Cord Group, West Medical Building, Institute of Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
    Eur J Neurosci 20:3301-12. 2004
    ..We have used an antigen-unmasking method involving pepsin treatment to reveal NR1, NR2A and NR2B subunits and have compared their distribution with that of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic ..
  16. ncbi Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons
    Hai Yan Wu
    Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    J Biol Chem 280:21588-93. 2005
    ..Immunoblotting analysis showed that the NR2A and NR2B subunits of NMDARs were markedly degraded in cultured cortical neurons treated with glutamate, and the degradation ..
  17. ncbi Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking
    Myung Jong Kim
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neuron 46:745-60. 2005
    ..In mature cultured neurons, NR2A-NMDARs promote, whereas NR2B-NMDARs inhibit, the surface expression of GluR1, primarily by regulating its surface insertion...
  18. ncbi N-methyl-D-aspartate receptor subtype mediated bidirectional control of p38 mitogen-activated protein kinase
    Elisa A Waxman
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Biol Chem 280:29322-33. 2005
    ..dephosphorylation of p38 in a manner involving both NR1/2A/2B receptor activation and tyrosine phosphorylation of NR2B. The ability of NMDAR subtype-specific mechanisms to regulate p38 has implications for NMDAR-mediated synaptic ..
  19. ncbi Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory
    Ming Gao Zhao
    Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, 220 Han Dan Road, Shanghai 200433, China
    Neuron 47:859-72. 2005
    ..In particular, it has been suggested that NR2A-containing NMDA receptors are involved in LTP induction, whereas NR2B-containing receptors are involved in LTD induction in the hippocampus...
  20. ncbi Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors
    MiOu Zhou
    Neuroscience Program, University of Southern California, Los Angeles, California 90089 2520, USA
    J Neurosci 26:2956-63. 2006
    ..5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate (MK-801) and by the antagonists of NR2B receptor ifenprodil and R-(R, S)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propranol and ..
  21. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    Thomas E Bartlett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Neuropharmacology 52:60-70. 2007
    ..Against recombinant receptors in HEK293 cells NVP-AAM077 (NVP) was approximately 14-fold selective for NR2A vs NR2B receptors, whilst Ro 25-6981 (Ro) was highly selective for NR2B receptors...
  22. pmc NMDA receptor surface mobility depends on NR2A-2B subunits
    Laurent Groc
    Physiologie Cellulaire de la Synapse, Unité Mixte de Recherche UMR 5091, Centre National de la Recherche Scientifique CNRS, Universite Bordeaux 2, 33077 Bordeaux, France
    Proc Natl Acad Sci U S A 103:18769-74. 2006
    ..In particular, synaptic NMDAR switch from containing mostly NR2B subunit to a mixture of NR2B and NR2A subunits...
  23. ncbi A three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit
    Wei Yang
    Department of Neurobiology, Institute for Neuroscience, Zhejiang University School of Medicine, Hangzhou 3100058, China
    J Biol Chem 282:9269-78. 2007
    ....
  24. pmc In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    M A Martel
    Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuroscience 158:334-43. 2009
    It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of ..
  25. pmc Dopamine receptors regulate NMDA receptor surface expression in prefrontal cortex neurons
    Can Gao
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurochem 106:2489-501. 2008
    ..Immunocytochemical analysis demonstrated that surface expression (synaptic and non-synaptic) of NR1 and NR2B on PFC pyramidal neurons was increased by the D1 receptor agonist SKF 81297 (1 microM, 5 min)...
  26. pmc Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats
    Xue Han Zhang
    Institutes of Brain Science, Fudan University, Shanghai, PR China
    Mol Brain 1:9. 2008
    ..Studies using genetic and pharmacological approaches have reported inconsistent results of the requirement of NR2B-containing NMDARs in LTP in the CA1 region...
  27. doi Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation
    Szu Han Wang
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 12:905-12. 2009
    ..At the molecular level, we demonstrate that NR2B NMDA-receptor subunits which are critical for the induction of reconsolidation of auditory memories in the amygdala,..
  28. pmc Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit
    Erkan Karakas
    WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    EMBO J 28:3910-20. 2009
    ..Here, we report the crystal structures of ATD from the NR2B NMDA receptor subunit in the zinc-free and zinc-bound states...
  29. pmc Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation
    Kelly A Foster
    Department of Basic Science, The Commonwealth Medical College, Scranton, Pennsylvania 18510, USA
    J Neurosci 30:2676-85. 2010
    ..are critical mediators of activity-dependent synaptic plasticity, but the differential roles of NR2A- versus NR2B-containing NMDARs have been controversial...
  30. doi Neuroprotective effects of hydroxysafflor yellow A against excitotoxic neuronal death partially through down-regulation of NR2B-containing NMDA receptors
    Q Yang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    Neurochem Res 35:1353-60. 2010
    ..In addition, HSYA significantly reversed up-regulation of NR2B-containing NMDA receptors by exposure to NMDA, while it did not affect the expression of NR2A-containing NMDA ..
  31. pmc NMDA receptor subunit composition controls synaptogenesis and synapse stabilization
    Abigail C Gambrill
    Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195 7290, USA
    Proc Natl Acad Sci U S A 108:5855-60. 2011
    ..synaptogenesis occurs in parallel with a developmental switch in the subunit composition of NMDA receptors from NR2B to NR2A...
  32. pmc Differential role of NR2A and NR2B subunits in N-methyl-D-aspartate receptor antagonist-induced aberrant cortical gamma oscillations
    Bernat Kocsis
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts MA02215, USA
    Biol Psychiatry 71:987-95. 2012
    ..These neurons are critical for gamma oscillations, indicating that pathological changes in gamma activity may depend on subunit-specific NMDA-R deficit. The present study tested this hypothesis...
  33. pmc Mechanisms of CaMKII action in long-term potentiation
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 13:169-82. 2012
    ..These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse...
  34. pmc Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95
    Sarah L Cousins
    University College London School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    J Biol Chem 287:13465-76. 2012
    ..challenged this dogma to demonstrate a second non-ES(E/D)V PSD-95-binding site in both NMDA receptor NR2A and NR2B subunits...
  35. ncbi Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices
    Andrew P Mallon
    Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, West Medical Building, University of Glasgow, Glasgow
    Exp Brain Res 162:374-83. 2005
    ..Here, we have examined the effects of selective antagonists of NR2A and NR2B subunits (NVP-AAM07 and Ro25-6981 respectively) on the effects of NMDA in the CA1 field of rat hippocampal slices...
  36. ncbi Effect of cigarette smoke on lipid peroxidation, antioxidant enzymes and NMDA receptor subunits 2A and 2B concentration in rat hippocampus
    Namik Delibas
    Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine, University of Suleyman Demirel, Turkey
    Cell Biochem Funct 21:69-73. 2003
    ....
  37. ncbi Alterations of NR2B and PSD-95 expression after early-life epileptiform discharges in developing neurons
    Qian Jiang
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Int J Dev Neurosci 25:165-70. 2007
    ..We found a decrease in expression of NR2B NMDAR subunit and PSD-95 (P<0...
  38. doi Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B
    Hsien Yu Peng
    Department of Physiology, College of Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan
    Am J Physiol Renal Physiol 298:F109-17. 2010
    ..test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between ..
  39. doi Effects of NR2A and NR2B-containing N-methyl-D-aspartate receptors on neuronal-firing properties
    Meimei Shi
    College of Life Sciences, Shaanxi Normal University, Xi an, Shaanxi, P R China
    Neuroreport 22:762-6. 2011
    ..activation of NR2A-containing NMDARs mediated the enhancement of spike adaptation, whereas selective activation of NR2B-containing NMDARs increased the intrinsic excitability, suggesting that NR2A-containing and NR2B-containing NMDARs ..
  40. ncbi Expression of N-methyl-D-aspartate (R)(GluN2B) - subunits in the brain structures of rats selected for low and high anxiety
    M Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    J Physiol Pharmacol 62:473-82. 2011
    In this paper, we studied differences in the density of N-methyl-D-aspartate (NMDA) receptor GluN2B subunits in the brains of low (LR) and high (HR) anxiety rats subjected to extinction trials and re-learning of a conditioned fear ..
  41. doi Mass spectrometrical identification of hippocampal NMDA receptor subunits NR1, NR2A-D and five novel phosphorylation sites on NR2A and NR2B
    Maryam Ghafari
    Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18 1090 Vienna, Austria
    J Proteome Res 11:1891-6. 2012
    ..On NR2A, a novel phosphorylation site was observed at S511, and on NR2B, four novel phosphorylation sites were revealed at S886, S917, S1303, and S1323 by mass spectrometry and verified ..
  42. doi Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease
    Adrien Quintana
    Institut National de la Sante et de la Recherche Medicale, Unite 836, Grenoble Institut des Neurosciences, Dynamique et Physiopathologie des Ganglions de la Base, Grenoble F 38043, France
    Neurobiol Dis 48:379-90. 2012
    ..Here, we investigated the possible association between L-DOPA- and STN-HFS-induced dyskinesia and regulation of the NR2B subunit of NMDA receptors in the rodent model of PD...
  43. pmc Delay-dependent impairment of spatial working memory with inhibition of NR2B-containing NMDA receptors in hippocampal CA1 region of rats
    Xue Han Zhang
    Institute of Neurobiology, and State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, China
    Mol Brain 6:13. 2013
    ..Although evidence from genetic manipulation mice suggests an important role of hippocampal NMDAR NR2B subunits (NR2B-NMDARs) in spatial working memory, it remains unclear whether or not the requirement of hippocampal ..
  44. doi Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 [corrected]
    Toshinori Yoshioka
    Department of Biochemistry, Faculty of Medicine Graduate School of Medicine, University of Yamanashi, Japan
    FEBS Lett 587:1453-9. 2013
    ..Furthermore, the C-terminal PDZ-binding motif of Vangl2 is required for localization to dendritic spines. These results suggest that Vangl2 is a new component of the PSD that forms a complex with PSD-95 in the adult brain...
  45. pmc Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats
    Wei Hua Lee
    Department of Medical Genetics, University of Wisconsin, Madison, WI, USA
    Neurobiol Aging 35:1459-68. 2014
    ..The results suggest that overexpression of neuronal SOD1 and CAT in middle age may provide a model for examining the role of oxidative stress in senescent physiology and the progression of age-related neurodegenerative diseases...
  46. pmc Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses
    Julien P Dupuis
    Interdisciplinary Institute for Neuroscience University de Bordeaux UMR 5297, Bordeaux, France
    EMBO J 33:842-61. 2014
    ..of synaptic NMDAR can be rapidly modified, as in neonatal hippocampal synapses where a switch from predominant GluN2B- to GluN2A-containing receptors is observed after the induction of long-term potentiation (LTP)...
  47. pmc PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors
    Fernando J Bustos
    Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago, Chile Faculty of Biological Science, Universidad de Concepcion, Concepcion, Chile FONDAP Center for Genome Regulation, Santiago, Chile
    PLoS ONE 9:e94037. 2014
    Considerable evidence indicates that the NMDA receptor (NMDAR) subunits NR2A and NR2B are critical mediators of synaptic plasticity and dendritogenesis; however, how they differentially regulate these processes is unclear...
  48. pmc Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus
    Jinhua Ma
    Department of Biological Sciences, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701, Republic of Korea
    Mol Brain 7:33. 2014
    ..Therefore, it is suggested that chronic inflammation may alter expression levels of GluN2A and GluN2B subunits of NMDA receptors and associated intracellular signalling...
  49. doi Hippocampal NR2B-containing NMDA receptors enhance long-term potentiation in rats with chronic visceral pain
    Yu Chen
    Fujian Medical University, Department of Physiology and Pathophysiology, Laboratory of Pain Research, Key Laboratory of Brain Aging and Neurodegenerative Diseases, Neuroscience Research Center, Fuzhou City, Fujian Province 350108, PR China
    Brain Res 1570:43-53. 2014
    ..Activation of the N-methyl-D-aspartic acid receptors 2B subunits (NR2B-NMDAs) is responsible for the hippocampal LTP in memory formation...
  50. pmc FRET-FLIM investigation of PSD95-NMDA receptor interaction in dendritic spines; control by calpain, CaMKII and Src family kinase
    Kim Doré
    Institut universitaire en santé mentale de Québec, Universite Laval, Quebec, QC, Canada
    PLoS ONE 9:e112170. 2014
    ..roles for CaMKII, SFK and calpain activity in regulating activity-dependent separation of PSD95 from GluN2A or GluN2B. Finally, we found that calpain inhibition reduced spine growth that was caused by NMDAR activity, supporting the ..
  51. doi Anxious phenotypes plus environmental stressors are related to brain DNA damage and changes in NMDA receptor subunits and glutamate uptake
    Gislaine Z Réus
    Laboratorio de Neurociencias, Programa de Pos Graduacao em Ciencias da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston, Houston, TX, USA Electronic address
    Mutat Res 772:30-7. 2015
    ..NMDRA2A in the NAc was increased after stress, and decreased in the CLF. NMDAR2B were increased in the hippocampus of CLF and CHF...
  52. doi Identification of a Novel Rat NR2B Subunit Gene Promoter Region Variant and Its Association with Microwave-Induced Neuron Impairment
    Li Feng Wang
    Laboratory of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China
    Mol Neurobiol 53:2100-11. 2016
    ..In this study, single nucleotide polymorphism (SNP) sites in the rat GRIN2B promoter region were screened...
  53. pmc Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 29:15551-63. 2009
    ..Furthermore, high dose of dopamine failed to affect NMDA receptor-mediated currents after blockade of NR2B subunits but triggered a dynamin-dependent endocytosis of NMDA receptors...
  54. pmc CaMKII regulation in information processing and storage
    Steven J Coultrap
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Trends Neurosci 35:607-18. 2012
    ..Recent findings also implicate CaMKII in long-term depression (LTD), as well as functional roles at inhibitory synapses, lending renewed emphasis on better understanding the spatiotemporal control of CaMKII regulation...
  55. pmc Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors
    Kevin She
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    J Biol Chem 287:27432-45. 2012
    ..We expressed a panel of GluN2B ligand binding mutants in heterologous cells with GluN1 or in rat cultured neurons and found that surface ..
  56. doi Effects of metabotropic glutamate mGlu5 receptor antagonist on tyrosine phosphorylation of NMDA receptor subunits and cell death in the hippocampus after brain ischemia in rats
    Norio Takagi
    Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Neurosci Lett 530:91-6. 2012
    ..Tyrosine phosphorylation of the NR2A subunit, but not that of the NR2B one, was inhibited by the mGlu5 receptor antagonist...
  57. pmc Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression
    Helmut W Kessels
    Center for Neural Circuits and Behavior, Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:4033-8. 2013
    ..Aβ activates this metabotropic NMDAR function on GluN2B-containing NMDARs but not on those containing GluN2A...
  58. pmc N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit
    Pallab Singh
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:4348-59. 2012
    ..of specific subtypes and demonstrate that the mechanosensitive property is uniquely governed by the NR2B subunit...
  59. ncbi The effects of exercise intensity on p-NR2B expression in cerebral ischemic rats
    Anjing Zhang
    Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China
    Can J Neurol Sci 39:613-8. 2012
    The current study explored the effects of treadmill exercise intensity on functional recovery and hippocampal phospho-NR2B (p-NR2B) expression in cerebral ischemic rats, induced by permanent middle cerebral artery occlusion (MCAO) surgery.
  60. doi Ex vivo depotentiation of conditioning-induced potentiation at thalamic input synapses onto the lateral amygdala requires GluN2B-containing NMDA receptors
    Sungmo Park
    School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 742, South Korea
    Neurosci Lett 530:121-6. 2012
    ..Surprisingly, as shown in our and other previous studies, ifenprodil, an antagonist of GluN2B-containing NMDA receptors, fails to inhibit depotentiation(ex vivo) at a saturating concentration (10μM), ..
  61. ncbi Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence
    D I Peregud
    Laboratory of Biochemistry, National Research Center of Narcology, Russian Ministry of Health and Social Development, Moscow, Russia
    Bull Exp Biol Med 153:835-8. 2012
    ..By contrast, the expression of mRNA for the Grin2b subunit in the striatum decreased in animals with mild abstinence...
  62. ncbi Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor
    J M Sullivan
    Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037
    Neuron 13:929-36. 1994
    ..residue in the NMDAR1 (NR1) subunit and each conserved NMDAR2 (NR2) cysteine residue in a prototypical subunit (NR2B) was tested for its role in redox modulation...
  63. ncbi An NMDA receptor signaling complex with protein phosphatase 2A
    S F Chan
    Department of Biology and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region, China
    J Neurosci 21:7985-92. 2001
    ....
  64. ncbi Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum
    David E Chapman
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City 84112, USA
    J Neurophysiol 89:69-80. 2003
    ..NR2 subunits confer different pharmacological and biophysical properties to NMDARs. Although NR2B subunit expression is uniform throughout striatum, NR2A subunit expression is greater laterally...
  65. ncbi Long-term regulation of N-methyl-D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity
    J M Williams
    Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, P O Box 913, Dunedin, New Zealand
    Neuroscience 118:1003-13. 2003
    ..stimulation that produced a mild synaptic depression resulted in a decrease in the NMDA receptor subunits NR1 and NR2B 48 h following stimulation...
  66. ncbi Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release
    Nils Ole Dalby
    Department of Neurology, The David Geffen School of Medicine at UCLA, 90095 1769, USA
    J Neurophysiol 90:786-97. 2003
    ..8 +/- 3.0 pA, thus identifying a tonic conductance mediated by NMDA receptors. The NR2B antagonist ifenprodil (10 microM) significantly reduced the frequency of spontaneous events but had no effect on ..
  67. ncbi Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits
    Catrin Wernicke
    Department of Clinical Neurobiology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Biol Psychiatry 54:922-8. 2003
    ..This study examined the hypothesis that allelic variants of the ionotropic glutamatergic N-methyl-D-aspartate receptor (NMDAR) are associated with vulnerability to alcoholism and some related traits...
  68. pmc Upregulation of glutamate receptors in rat cerebral cortex with neuronal migration disorders
    Min Cheol Lee
    Department of Pathology, Chonnam National University Medical School, Gwangju, Korea
    J Korean Med Sci 19:419-25. 2004
    ..The results of the present study indicate that epileptogenesis of NMD might be caused by upregulation of glutamate receptor expression in dysplastic neurons of the rat cerebral cortex with NMDs...
  69. ncbi Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors
    Ezekiel P Carpenter-Hyland
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 24:7859-68. 2004
    ..Similar effects were observed with NR2B clustering after chronic ethanol exposure...
  70. pmc Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles
    Kevin Erreger
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, GA 30322 3090, USA
    J Physiol 563:345-58. 2005
    NR2A and NR2B are the predominant NR2 NMDA receptor subunits expressed in cortex and hippocampus...
  71. ncbi Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 32:377-87. 2007
    ..changes were associated with parallel alterations in expression levels and/or phosphorylation changes in the NR2B and GluR1 subunits of the respective NMDA and AMPA receptors...
  72. ncbi Learning in the absence of experience-dependent regulation of NMDAR composition
    David Lebel
    Department of Orthopedic Surgery, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, 84105 Israel
    Learn Mem 13:566-70. 2006
    ..function of NMDARs at synapses in the piriform cortex, resulting in a high level of the NR2a subunit relative to NR2b. Here we show that the learning-induced changes in NMDAR composition in the adult piriform cortex are due to a ..
  73. ncbi Modulation of D2R-NR2B interactions in response to cocaine
    Xian Yu Liu
    Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri 64108, USA
    Neuron 52:897-909. 2006
    ..by cocaine enhances a heteroreceptor complex formation between dopamine D2 receptors (D2R) and NMDA receptor NR2B subunits in the neostriatum in vivo...
  74. ncbi Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: a HuGE review and meta-analysis
    Dawei Li
    Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Genet Med 9:4-8. 2007
    ..Association studies have implicated the N-methyl-D-aspartate receptor 2B subunit gene (GRIN2B) as a candidate for schizophrenia...
  75. ncbi Contribution of NMDA receptor NR2B subunit to synaptic plasticity during associative learning in behaving rats
    Mauricio Valenzuela-Harrington
    Division de Neurociencias, Universidad Pablo de Olavide, Ctra de Utrera, km 1, 41013 Sevilla, Spain
    Eur J Neurosci 25:830-6. 2007
    ..Here, we show that Ro 25-6981, a high-affinity and selective blocker of NMDA receptors containing NR2B subunits, is able to block the acquisition of a trace conditioning paradigm in adult rats, a task that requires the ..
  76. ncbi Nandrolone-induced hippocampal phosphorylation of NMDA receptor subunits and ERKs
    Uwe L W Rossbach
    Department of Pharmaceutical Bioscience, Division of Biological Research on Drug Dependence, Uppsala University, BMC, Box 591, S 751 24 Uppsala, Sweden
    Biochem Biophys Res Commun 357:1028-33. 2007
    ..analysis revealed that a single injection of AAS increased phosphorylation of the NMDA receptor subunits NR2A and NR2B and ERK1/2, while the levels of phosphorylated CaMKIIalpha were unaltered...
  77. pmc Expression of the N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunit subtypes in the rat colon
    A Y Del Valle-Pinero
    Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Neuroscience 147:164-73. 2007
    ..The NR2B and NR2D subunits were also found in the rat colon...
  78. ncbi [Developmental changes in synaptic and extrasynaptic N-methyl-D-aspartate receptors in cultured rat hippocampal neurons]
    Ying hong Tian
    Department of Physiology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:634-7. 2007
    ..To investigate changes in synaptic and extrasynaptic N-methyl-D-aspartate receptors (NMDAR) during the development of cultured rat hippocampal neurons...
  79. doi The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene
    Jonathan M Levenson
    Galenea, Corp, Cambridge, MA 02139, USA
    Biochim Biophys Acta 1779:422-31. 2008
    ....
  80. doi The magnitude of hippocampal long term depression depends on the synaptic location of activated NR2-containing N-methyl-D-aspartate receptors
    M Kollen
    Faculte de Medecine, Centre de Psychiatrie et de Neuroscience U894 INSERM, Universite Paris Descartes, Paris, France
    Neuroscience 154:1308-17. 2008
    ..almost exclusively of NR1 and NR2 subunits with NR1 subunits being mainly associated with either NR2A and/or NR2B subunits. The role played by the different subunits in synaptic plasticity is still controversial...
  81. pmc Exposure to cyclic intermittent hypoxia increases expression of functional NMDA receptors in the rat carotid body
    Yuzhen Liu
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 106:259-67. 2009
    ..56 +/- 9.12%). We conclude that 3-wk CIH exposure increases expression of NMDA functional receptors in rats, suggesting glutamate and its receptors may play a role in hypoxic acclimatization to CIH...
  82. doi SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression
    Derek J C Tai
    Graduate Institute of Life Sciences, National Defense Medical Center, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 284:4073-89. 2009
    ..SGK1 enhanced nuclear factor kappaB (NF-kappaB) activity and up-regulated N-methyl-d-aspartate receptor NR2A and NR2B expression through activation of IKKalpha at Thr-23 and Ser-180, and these two residues play an equally important ..
  83. pmc Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:8054-63. 2009
    ..hippocampus, the majority of NMDA receptors are heteromeric; most are composed of 2 NR1 subunits and 2 NR2A or 2 NR2B subunits...
  84. pmc Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures
    Xavier d'Anglemont de Tassigny
    INSERM, Jean Pierre Aubert Research Centre, Unit 837, Development and Plasticity of the Postnatal Brain, Place de Verdun, Lille Cedex, France
    J Neurochem 109:214-24. 2009
    ..coupling of the calcium-activated neuronal NO synthase (nNOS) to glutamate NMDA receptor channels harboring NR2B subunits by the scaffolding protein post-synaptic density-95 (PSD-95), and that estrogens promote the formation of ..
  85. doi NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins
    Catherine Croft Swanwick
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS Lett 583:1226-30. 2009
    ..Here we demonstrate interactions between the NR2A and NR2B subunits of NMDARs with flotillin-1 (flot-1), a lipid raft-associated protein...
  86. doi Decline of long-term potentiation (LTP) in the rat auditory cortex in vivo during postnatal life: involvement of NR2B subunits
    Jennifer L Hogsden
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Brain Res 1283:25-33. 2009
    ..Application of an antagonist of NMDA receptor NR2B subunits (Ro 25-6981, 10 mM) in A1 reduced LTP in PD 30-35 rats to levels similar to those in adults without ..
  87. doi Estrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats
    Hsien Yu Peng
    Department of Physiology, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan
    Am J Physiol Endocrinol Metab 297:E416-26. 2009
    ..100 nM, 10 microl it), ERK inhibitor (U-0126; 100 microM, 10 microl it) and N-methyl-D-aspartate (NMDA) NR2B subunit antagonist (Co-101244; 100 nM, 10 microl it)...
  88. doi Metaplastic regulation of long-term potentiation/long-term depression threshold by activity-dependent changes of NR2A/NR2B ratio
    Zhuo Xu
    Department of Neurobiology, Key Laboratory for Neurodegenerative Disease of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu Province 210029, People s Republic of China
    J Neurosci 29:8764-73. 2009
    ..stimulations (PSs) across a wide range of frequencies (1-100 Hz) could induce bidirectional changes in the NR2A/NR2B ratio, which governs the threshold for subsequent long-term potentiation/long-term depression (LTP/LTD)...
  89. doi Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate
    Yusuke Nakatsu
    Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Toxicol Appl Pharmacol 240:292-8. 2009
    ..to 20 nM TBT decreased the mRNA expression of glutamate receptors NR1, NR2A, GluR1 and GluR2, and increased that of NR2B, GluR3 and GluR4. GluR2 protein was also reduced by long-term exposure to TBT...
  90. doi Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons
    Bin Xu
    Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001, People s Republic of China
    Neurotoxicology 30:941-9. 2009
    ..subunits in neuron and expression of NR2A mRNA and protein were much more sensitive to Mn than those of NR1 and NR2B. In conclusion, the present results showed that Mn-induced neuronal damage by increasing [Ca(2+)](i) and altering ..
  91. doi NR2B subunit-dependent long-term potentiation enhancement in the rat cortical auditory system in vivo following masking of patterned auditory input by white noise exposure during early postnatal life
    Jennifer L Hogsden
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Eur J Neurosci 30:376-84. 2009
    ..We explored the mechanisms mediating white noise-induced plasticity enhancements by local NR2B subunit antagonist application in A1...
  92. pmc Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats
    Ilona Obara
    Department of Psychology, University of California, Santa Barbara, CA, USA
    Alcohol Clin Exp Res 33:1924-34. 2009
    ....
  93. doi Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices
    S Dos-Anjos
    Area de Biología Celular, Instituto de Biomedicina, Universidad de Leon, 24071, Leon, Spain
    Neuroscience 164:1119-26. 2009
    ..Here we report short-term changes in the mRNA levels of the major hippocampal NMDAR subunits (NR1, NR2A and NR2B), as well as c-fos, in an ex vivo ischemia model using hippocampal slices...
  94. doi Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors
    A Stamatakis
    Biology Biochemistry Lab, Faculty of Nursing, University of Athens, 11527 Athens, Greece
    Neuroscience 164:1457-67. 2009
    ..of two obligatory, channel forming NR1 subunits and two regulatory subunits, usually a combination of NR2A and NR2B. Since the subunit composition of the NMDA receptor affects brain plasticity, in the present study we investigated ..
  95. doi Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats
    Fuzhou Wang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Jiangsu, China
    Pain 148:275-83. 2010
    ..Mechanistic studies revealed that MIF upregulated the expression of the spinal NMDA receptor subunit NR2B via the MAPK signaling pathway...
  96. pmc Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor
    X K Wee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore
    Br J Pharmacol 159:449-61. 2010
    ..5-substituted benzimidazole derivatives [N-{2-[(4-benzylpiperidin-1-yl)methyl]benzimidazol-5-yl}methanesulphonamide (XK1) and N-[2-(4-phenoxybenzyl)benzimidazol-5-yl]methanesulphonamide (XK2)] on the GluN2B subunit of the NMDA receptor.
  97. doi Chronic unpredictable stress before pregnancy reduce the expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor in hippocampus of offspring rats associated with impairment of memory
    Yuejun Huang
    The Department of Pediatrics, The Second Affiliated Hospital of Medical College of Shantou University, North Dongxia Road, 515041, Shantou, Guangdong Province, China
    Neurochem Res 35:1038-49. 2010
    ..well as the expression of brain-derived neurotrophic factor (BDNF), N-methyl-D-aspartate (NMDA) 2A (NR2A) and 2B (NR2B) receptors in the hippocampus of the offspring rats when they were 2 months postnatally...
  98. doi Induced tolerance to glutamate neurotoxicity through down-regulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons
    Yuki Kambe
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan
    J Neurosci Res 88:2177-87. 2010
    ..However, calpain inhibitor-I significantly prevented the decreased NR2B and NR2C protein levels in striatal neurons cultured with NMDA...
  99. ncbi [Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]
    Pu Huang
    Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi an Jiaotong University Coolege of Medicine, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:708-11. 2010
    To study the effect of behavioral training on the learning and memory abilities and changes of NR2B and GluR1 expressions in the hippocampus of offspring rats with fetal growth retardation (FGR).
  100. ncbi Effects of electroconvulsive therapy and propofol on spatial memory and glutamatergic system in hippocampus of depressed rats
    Jun Dong
    Department of Anesthesiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    J ECT 26:126-30. 2010
    ..This animal study tested the spatial learning memory of "depressed" rats undergoing electroconvulsive therapy (ECT) or ECT combined with propofol and aimed to reveal the glutamatergic mechanisms in the hippocampus...
  101. doi N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95
    Jing Fan
    Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada
    J Neurochem 115:1045-56. 2010
    ..effects of Tat-NR2B9c, a membrane-permeant peptide that disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95...

Research Grants5

  1. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
    ....
  2. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  3. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  4. Cell-permeable inibitors specific for CaMKII
    K Ulrich Bayer; Fiscal Year: 2006
    ..modes of CaMKII activity (calcium/calmodulin-stimulated, autonomous by autophosphorylation, and autonomous by NR2B binding)...
  5. CaMKII signaling in insulin secretion and response
    K Ulrich Bayer; Fiscal Year: 2007
    ..3) Test feasibility of methods to study function of specific CaMKII isoforms in beta cells and islets. [unreadable] [unreadable]..