interleukin 13

Summary

Gene Symbol: interleukin 13
Description: interleukin 13
Alias: interleukin-13, IL-13, T-cell activation protein P600
Species: rat

Top Publications

  1. ncbi Regulation of acute lung inflammatory injury by endogenous IL-13
    A B Lentsch
    Department of Surgery, University of Louisville School of Medicine, KY 40223, USA
    J Immunol 162:1071-6. 1999
  2. pmc Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema
    T Zheng
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 106:1081-93. 2000
  3. ncbi Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma
    Mariko Matsushita
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Int Arch Allergy Immunol 135:348-56. 2004
  4. ncbi Association of gene polymorphisms of tumour necrosis factor-alpha and interleukin-13 with chronic obstructive pulmonary disease in Han nationality in Beijing
    Ling Jiang
    Department of Pulmonary Disease, Peking University Third Hospital, Beijing 100083, China
    Chin Med J (Engl) 118:541-7. 2005
  5. ncbi IL-13 is essential to the late-phase response in allergic rhinitis
    Satoko Miyahara
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 118:1110-6. 2006
  6. doi IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death
    Shing Hwa Liu
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Mol Life Sci 67:1465-76. 2010
  7. ncbi Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis
    R U Pawankar
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Am J Respir Crit Care Med 152:2059-67. 1995
  8. ncbi Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis
    M Hasegawa
    Department of Dermatology, Kanazawa University School of Medicine, Japan
    J Rheumatol 24:328-32. 1997
  9. ncbi Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
    Nat Med 9:582-8. 2003
  10. ncbi A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis
    Min Wang
    Department of ENT, People s Hospital, Peking University, 11 Xi Zhi Men Nan Da Jie, 100044, Beijing, P R China
    Hum Genet 113:387-90. 2003

Scientific Experts

Detail Information

Publications107 found, 100 shown here

  1. ncbi Regulation of acute lung inflammatory injury by endogenous IL-13
    A B Lentsch
    Department of Surgery, University of Louisville School of Medicine, KY 40223, USA
    J Immunol 162:1071-6. 1999
    ..These data suggest that during lung inflammation endogenous IL-13 regulates NF-kappaB activation and related cytokine/chemokine generation, all of which determines the intensity of the lung inflammatory response...
  2. pmc Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema
    T Zheng
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 106:1081-93. 2000
    ..They also demonstrate that IL-13 causes emphysema via a MMP- and cathepsin-dependent mechanism(s) and highlight common mechanisms that may underlie COPD and asthma...
  3. ncbi Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma
    Mariko Matsushita
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Int Arch Allergy Immunol 135:348-56. 2004
    ..Previously, a murine model for scleroderma has been established by repeated local injections of bleomycin. This animal model enabled us to study local expression and production of IL-13 in skin lesions during disease progression...
  4. ncbi Association of gene polymorphisms of tumour necrosis factor-alpha and interleukin-13 with chronic obstructive pulmonary disease in Han nationality in Beijing
    Ling Jiang
    Department of Pulmonary Disease, Peking University Third Hospital, Beijing 100083, China
    Chin Med J (Engl) 118:541-7. 2005
    ....
  5. ncbi IL-13 is essential to the late-phase response in allergic rhinitis
    Satoko Miyahara
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 118:1110-6. 2006
    ..The pathophysiology of the early- and late-phase nasal response to allergen challenge is not completely defined. Recent technical advances enable direct monitoring of these responses in mice...
  6. doi IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death
    Shing Hwa Liu
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Mol Life Sci 67:1465-76. 2010
    b>Interleukin 13 (IL-13) has been shown to induce the death of activated microglia...
  7. ncbi Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis
    R U Pawankar
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Am J Respir Crit Care Med 152:2059-67. 1995
    ..b>Interleukin 13 (IL-13) is a novel T-cell-derived cytokine that shares several functional properties with IL-4 and has been ..
  8. ncbi Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis
    M Hasegawa
    Department of Dermatology, Kanazawa University School of Medicine, Japan
    J Rheumatol 24:328-32. 1997
    ..To determine whether serum interleukin 4 (IL-4), IL-10, and IL-13 levels in patients with systemic sclerosis (SSc) are elevated and whether they correlate with the clinical or serologic features of this disease...
  9. ncbi Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
    Nat Med 9:582-8. 2003
    ..Therapies that target V(alpha)14i NKT cells may be clinically effective in limiting the development of AHR and asthma...
  10. ncbi A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis
    Min Wang
    Department of ENT, People s Hospital, Peking University, 11 Xi Zhi Men Nan Da Jie, 100044, Beijing, P R China
    Hum Genet 113:387-90. 2003
    ..b>Interleukin 13 (IL-13) has been implicated in the pathogenesis and in the regulation of immunoglobulin E (IgE) production...
  11. ncbi Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma
    Hyo Bin Kim
    Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong Songpa gu, and Hangang Sacred Heart Hospital, Seoul, 138 736, Korea
    J Hum Genet 51:1055-62. 2006
    ..002, 0.010). These findings indicate that the IL-13 G+2044A is associated with asthma development and the IL-13 and IL-13Ralpha1 polymorphisms may interact to enhance IgE production...
  12. ncbi Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis
    Jeong Joong Kim
    Department of Anatomy, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea
    Eur Arch Otorhinolaryngol 264:395-9. 2007
    ..Our results suggest that the IL-13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans, whereas the IL-4Ralpha Gln551Arg polymorphism is not related to allergic rhinitis...
  13. ncbi IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome
    Michael P Keane
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 178:511-9. 2007
    ..This supports the notion that IL-13 biological axis plays an important role during the pathogenesis of BOS independent of the IL-4 biological axis...
  14. pmc Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood
    S H Arshad
    The David Hide Asthma and Allergy Research Centre, St Mary s Hospital, Newport, Isle of Wight and IIR Research Division, University of Southampton, Southampton, UK
    Br J Dermatol 158:1315-22. 2008
    Atopic eczema is characterized by Th2-dominant immunity with the cytokine interleukin 13 and the transcription factor GATA binding protein 3 playing a critical role.
  15. doi Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking
    Kristina Callis Duffin
    Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, Utah 84132, USA
    J Invest Dermatol 129:2777-83. 2009
    ..88, P=0.74, CC/non-smoker, prevalence 42% (reference), CC/smoker prevalence 47%, OR 1.21, P=0.47). This study suggests that IL13 polymorphisms associate most strongly with PsA and that smoking may modulate this effect...
  16. ncbi Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent
    Bibo Ke
    The Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Transplant 3:1076-82. 2003
    ..This study provides the rationale for novel approaches to maximize organ donor pool through the safer use of OLTs despite prolonged periods of cold ischemia...
  17. pmc Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function
    Sung Woo Park
    Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
    J Korean Med Sci 24:614-20. 2009
    ..IL-13 and its receptors may contribute to the pathogenesis of fibrosis in IIP and appear to be related to the severity of the disease...
  18. pmc Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension
    Romy B Christmann
    Boston University School of Medicine, E501 Arthritis Center, Boston, Massachusetts 02118 2526, USA
    Arthritis Rheum 63:1718-28. 2011
    ..To explore the relationship between biomarkers of pulmonary arterial hypertension (PAH), interferon (IFN)-regulated gene expression, and the alternative activation pathway in systemic sclerosis (SSc)...
  19. doi Potential role of IL-13 in neuroprotection and cortical excitability regulation in multiple sclerosis
    S Rossi
    Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mult Scler 17:1301-12. 2011
    ..Inflammation triggers secondary neurodegeneration in multiple sclerosis (MS)...
  20. doi Association between non-atopic hand eczema and interleukin-13 gene polymorphism in Taiwanese nursing population
    Yin Chun Chen
    Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Department of Dermatology, Center of Excellence of Environmental Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Dermatology, Kaohsiung Municipal Ta Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Exp Dermatol 21:972-4. 2012
    ..As non-atopic hand eczema made up significant portion of occupational skin diseases, further studies should be focused on this commonly encountered skin condition...
  21. ncbi Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats
    E Cash
    INSERM U 283, Cochin Hospital, Paris, France
    J Immunol 153:4258-67. 1994
    ....
  22. ncbi Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks
    J H Ruth
    Department of Pathology, Veterans Affairs Medical Center, Ann Arbor, MI 48105, USA
    Cytokine 12:432-44. 2000
    ..In fact, IL-13 down-regulated itself and other type-2 cytokines. In summary, IL-4 and IL-13 have common and disparate regulatory functions in types 1 and 2 responses...
  23. ncbi A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Clin Exp Allergy 31:1515-21. 2001
    ..Previous studies showed that polymorphisms in the IL-13 gene were associated with serum total IgE or allergic asthma. The relationship of this marker with sensitization to individual aeroallergens has not been evaluated...
  24. ncbi Interleukin-13 in autoimmune rheumatic diseases: relationship with the autoantibody profile
    A Spadaro
    Department of Medical Therapy, University of Rome La Sapienza, Italy
    Clin Exp Rheumatol 20:213-6. 2002
    ..We investigated the relationship between the serum concentration of this cytokine and circulating autoantibodies...
  25. ncbi IL-13 is sufficient for respiratory syncytial virus G glycoprotein-induced eosinophilia after respiratory syncytial virus challenge
    Teresa R Johnson
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive MSC 3017, Building 40, Bethesda, MD 20892, USA
    J Immunol 170:2037-45. 2003
    ....
  26. ncbi Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation
    Mark A Birrell
    Respiratory Pharmacology, Cardiothoracic Surgery, Imperial College of Science, Technology and Medicine, Faculty of Medicine, National Heart and Lung Institute, London, United Kingdom
    J Pharmacol Exp Ther 304:1285-91. 2003
    ....
  27. ncbi Ultrastructural and immunological features of experimental cutaneous leishmaniasis after treatment with intralesional hypertonic sodium chloride and CO2 laser rays
    Maha M Eissa
    Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt
    J Egypt Soc Parasitol 33:329-52. 2003
    ..It is concluded that CO2 laser then 7% NaCl are good modalities for CL treatment and is recommended wherever possible...
  28. ncbi Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Dermatology 207:141-7. 2003
    ..The enhanced production of some cytokines may be related to the pathogenesis of localized scleroderma (LSc)...
  29. ncbi P-selectin inhibition decreases post-thrombotic vein wall fibrosis in a rat model
    Porama Thanaporn
    Section of Vascular Surgery, Department of Surgery, Jobst Vascular Laboratory and Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Surgery 134:365-71. 2003
    ..This study tested the hypothesis that P-selectin inhibition would decrease post-thrombotic vein wall fibrosis and associated profibrotic mediators...
  30. ncbi The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism
    Raafat Elnaggar
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Eur J Immunol 35:1995-2005. 2005
    ..We conclude that IL-13-Ig ameliorates EAM and suppose that its effectiveness may be due to the influence on these immunologic molecules in CD11b(+) and NCNI cells...
  31. pmc Th2 cytokine genotypes are associated with a milder form of primary Sjogren's syndrome
    M Pertovaara
    Department of Internal Medicine, Section of Rheumatology, Tampere University Hospital, PO Box 2000, FIN 33521 Tampere, Finland
    Ann Rheum Dis 65:666-70. 2006
    ..Immunohistological studies on salivary and lacrimal glands have yielded conflicting results on the Th1/Th2 balance in primary Sjögren's syndrome (pSS)...
  32. ncbi Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma
    Cristina Antunez
    Research Unit for Allergic Diseases, Allergic Service, Carlos Haya Hospital, Malaga, Spain
    Pediatr Allergy Immunol 17:166-74. 2006
    ..Moreover, the subpopulations (CLA+ vs. CLA-) expressing these changes were different, indicating that the underlying mechanisms in the two diseases are not exactly the same...
  33. ncbi IL-13 prolongs allograft survival: association with inhibition of macrophage cytokine activation
    Cassandra Davidson
    Department of Medicine, University of New South Wales, Sydney, NSW, Australia
    Transpl Immunol 17:178-86. 2007
    ....
  34. ncbi Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma
    Hitoe Torisu-Itakura
    Department of Molecular Therapeutics, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Clin Cancer Res 13:3125-32. 2007
    ..We hypothesize that the nodal profile of immunoregulatory cytokines can confirm the identity of the first tumor-draining regional node, i.e., the sentinel node (SN) and indicate its tumor status...
  35. doi A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma
    T Sugawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi Abenoku, Osaka 545 8585, Japan
    Gut 57:575-81. 2008
    ..Several studies have shown a strong association between reflux oesophagitis (RO) and bronchial asthma (BA). The precise mechanisms of interaction between RO and BA are uncertain, possibly due to lack of animal models...
  36. doi Systemic gene therapy with interleukin-13 attenuates renal ischemia-reperfusion injury
    M Sandovici
    Department of Clinical Pharmacology, Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 73:1364-73. 2008
    ..These results suggest that the use of systemic IL-13 gene therapy may be useful in reducing renal tubulointerstitial damage and inflammation caused by ischemia-reperfusion...
  37. doi IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis
    Simona Eva Zitnik
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 20:551-5. 2009
    ..b>Interleukin 13 (IL13) variants have been consistently associated with total serum IgE levels in white populations with a ..
  38. pmc Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection
    Victoria E Anderson
    School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Virology 391:25-32. 2009
    ..Our data therefore suggest that MAV-1 pathogenesis is not affected directly or indirectly by the Th2 polarization associated with allergic airway disease...
  39. doi Protective effect of Ulinastatin against murine models of sepsis: inhibition of TNF-α and IL-6 and augmentation of IL-10 and IL-13
    Yi Zhan Cao
    Department of Emergency, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, PR China
    Exp Toxicol Pathol 64:543-7. 2012
    ..However, it is unknown if Ulinastatin treatment could result in protective effects for sepsis. The aim of this study was to investigate the role of Ulinastatin on septic rats...
  40. pmc Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases
    N Inoue
    Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Exp Immunol 163:318-23. 2011
    ..In conclusion, functional polymorphisms in the genes encoding Th2 cytokines are associated differently with the development and prognosis of AITD from each other...
  41. pmc Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts
    Kelly L Asquith
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    PLoS Pathog 7:e1001339. 2011
    ..Collectively our findings demonstrate that innate IL-13 release promotes infection that results in enhanced inflammation and have broad implications for the treatment of chlamydial infections and IL-13-associated diseases...
  42. pmc Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria
    E Ayimba
    Centre National de Transfusion Sanguine, Section Immunologie et Hématologie, Universite de Lome, Lome, Togo
    Clin Exp Immunol 166:218-26. 2011
    ..The observed cytokine and chemokine production profiles and their dynamics may prove useful in evaluating either the progression or the regression of malarial disease...
  43. pmc Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study
    Yoshihiro Miyake
    Department of Preventive Medicine and Public Health, Fukuoka University, Japan
    BMC Med Genet 12:143. 2011
    ..We investigated the associations between IL13 SNPs rs1800925 and rs20541 and the risk of rhinoconjunctivitis in Japanese women...
  44. doi Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression
    Jasper C A Broen
    Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    J Rheumatol 39:112-8. 2012
    Polymorphisms in the genes encoding interleukin 4 (IL4), interleukin 13 (IL13), and their corresponding receptors have been associated with multiple immune-mediated diseases...
  45. ncbi Interleukin 13 expression in the primary breast cancer tumour tissue
    Nahida Srabovici
    Department of Biochemistry, Faculty of Pharmacy, University of Tuzla, Tuzla, Bosnia and Herzegovina
    Biochem Med (Zagreb) 21:131-8. 2011
    The aim of this study was to investigate the presence and the expression levels of the interleukin 13 (I1-13) in the primary breast cancer tumour tissue in relation to the unchanged breast tissue in the same patients and to the breast ..
  46. doi Relationship between pro-and anti-inflammatory cytokines profiles and some haematological parameters in some Cameroonians infected with Onchocerca volvulus
    O P G Nmorsi
    Tropical Disease Research Unit, Department of Zoology, Ambrose Alli University, Ekpoma, Nigeria
    Asian Pac J Trop Med 5:713-7. 2012
    ..To investigate the relationship between white blood cells, lymphocytes, monocytes, and Interleukin(IL)-1 α, IL-6, IL-10 and IL-13 production in Cameroonians with Onchocerca volvulus (O. volvulus) infection...
  47. ncbi Interleukin 13 cloning from DA rats
    X Y He
    University of New South Wales, Liverpool Hospital, Australia
    Transplant Proc 31:1572-3. 1999
  48. ncbi Expression and contribution of endogenous IL-13 in an experimental model of sepsis
    A Matsukawa
    Departments ofPathology and Internal Medicine, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 164:2738-44. 2000
    ..Collectively, these results suggest that endogenous IL-13 protected mice from CLP-induced lethality by modulating inflammatory responses via suppression of overzealous production of inflammatory cytokines/chemokines in tissues...
  49. ncbi Expression of a functional IL-13Ralpha1 by rat B cells
    C Pierrot
    Unité INSERM 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof Calmette, 59019 Lille, France
    Biochem Biophys Res Commun 287:969-76. 2001
    ....
  50. ncbi Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population
    T D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Respir Cell Mol Biol 25:377-84. 2001
    ..Further investigation is required to determine which specific alleles or combination of alleles contribute to these phenotypes, and the possible downstream effects of the resulting change in IL-13 levels or activity...
  51. ncbi Endogenous regulation of the acute inflammatory response
    Peter A Ward
    Department of Pathology, University of Michigan, Ann Arbor 48109, USA
    Mol Cell Biochem 234:225-8. 2002
    ..These data indicate that endogenous IL-10, IL-13 and SLPI are important regulators of the inflammatory response by reducing gene activation with resultant generation of peptide mediators/cytokines and chemokines...
  52. ncbi Potent antitumor activity of IL-13 cytotoxin in human pancreatic tumors engineered to express IL-13 receptor alpha2 chain in vivo
    K Kawakami
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29, 29 Lincoln Drive, Bethesda, MD 20892 4555, USA
    Gene Ther 10:1116-28. 2003
    ..Therefore, this approach may be a new powerful tool for pancreatic cancer or other localized cancer therapy...
  53. ncbi Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitis
    D Miotto
    Dept of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Eur Respir J 22:602-8. 2003
    ..In conclusion, T-helper-2 and -1 protein expression is present in the central airways of smokers and interleukin-4 and -13 could contribute to mucus hypersecretion in chronic bronchitis...
  54. ncbi [Dynamic changes and the meanings of blood cytokines in severe acute respiratory syndrome]
    Chen Wang
    Beijing Chaoyang Hospital Affiliate of Capital University of Medical Sciences, Beijing Institute of Respiratory Medicine, Beijing 100020, China
    Zhonghua Jie He He Hu Xi Za Zhi 26:586-9. 2003
    ..To investigate the dynamic changes observed in serum levels of interleukins (ILs), tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) in severe acute respiratory syndrome (SARS)...
  55. ncbi Differential expression of interleukins IL-13 and IL-15 in normal ovarian tissue and ovarian carcinomas
    Daylene Ripley
    Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610 0294, USA
    Gynecol Oncol 92:761-8. 2004
    ..To determine the temporal and spatial expression of interleukins (IL)-13 and IL-15 in ovarian carcinoma compared to normal ovarian tissue...
  56. ncbi [Study on the correlation of interleukin-13 polymorphism and susceptibility to chronic obstructive pulmonary disease in Chinese Han population]
    Rui Cheng Hu
    Department of Respiratory Medicine, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:607-11. 2004
    ..To investigate the polymorphism of interleukin (IL)-13 gene in Chinese Han population, and to study the possible association of IL-13 polymorphism and the susceptibility to chronic obstructive pulmonary disease (COPD)...
  57. ncbi Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
    Pediatr Pulmonol 39:219-23. 2005
    ..These results were associated with improvement in sympathetic regulation and decrease in IL-13 production. Milrinone therapy may provide a useful therapeutic approach for this highly lethal disorder...
  58. ncbi Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans
    Ioannis Moissidis
    Allergy and Immunology Section, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Genet Med 7:406-10. 2005
    ..We studied these SNPs in African Americans with asthma and/or atopy...
  59. ncbi Interleukin-13-dependent bronchial hyper-responsiveness following isolated upper-airway allergen challenge in a murine model of allergic rhinitis and asthma
    Y Wang
    Montreal Children s Hospital Research Institute, Montreal, Canada
    Clin Exp Allergy 35:1104-11. 2005
    ..We have previously shown that isolated allergic sensitization and challenge of the upper airway results in lower-airway inflammation, which supports the concept of the united airways...
  60. ncbi Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust
    J Kim
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Exp Allergy 36:122-32. 2006
    ....
  61. ncbi Enhanced allergic inflammation and airway responsiveness in rats with chronic Cryptococcus neoformans infection: potential role for fungal pulmonary infection in the pathogenesis of asthma
    David L Goldman
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 193:1178-86. 2006
    ..neoformans infection to potentiate allergic responses and airway reactivity and suggest a potential role for subclinical pulmonary cryptococcosis in the pathogenesis of asthma...
  62. ncbi Effect of tea polyphenol on cytokine gene expression in rats with alcoholic liver disease
    Xing Guo Zhang
    Department of Pharmacology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 5:268-72. 2006
    ..Green tea polyphenols have both antioxidant and antiinflammatory properties. This study was designed to evaluate the effect of tea polyphenol (TP) on alcohol-induced liver injury in rats...
  63. ncbi Evaluation of interleukin 13 polymorphisms in systemic sclerosis
    Brigitte Granel
    Laboratoire d Immunologie et de Génétique des Maladies Parasitaires, UMR 399 INSERM, Universite de la Mediterranee, Faculte de Medecine, 13005, Marseille, France
    Immunogenetics 58:693-9. 2006
    ..Our result supports the suggestion that polymorphisms in IL13 are associated to SSc and skin fibrosis process. However, further studies on larger and independent population and functional analyses are needed to confirm these findings...
  64. pmc Protein kinase Czeta (PKCzeta) regulates ocular inflammation and apoptosis in endotoxin-induced uveitis (EIU): signaling molecules involved in EIU resolution by PKCzeta inhibitor and interleukin-13
    Yvonne de Kozak
    INSERM U598, Centre Biomédical des Cordeliers, 15, rue de l Ecole de Medecine 75270, Paris Cedex 06, France
    Am J Pathol 170:1241-57. 2007
    ..Treatment accelerated endotoxin-induced uveitis resolution through premature apoptosis of neutrophils related to high expression of toll-like receptor 4 and caspase 3...
  65. ncbi IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 180:2376-84. 2008
    ....
  66. pmc IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, 3710 S W U S Veterans Hospital Road, Portland, OR 97239, USA
    J Immunol 180:2679-85. 2008
    ....
  67. doi Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma
    Alex G Therien
    Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec, Canada
    Am J Respir Cell Mol Biol 39:26-35. 2008
    b>Interleukin 13 (IL-13) is considered to be a key driver of the development of airway allergic inflammation and remodeling leading to airway hyperresponsiveness (AHR)...
  68. pmc Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    Shironjit K Saha
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:685-91. 2008
    ..The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined...
  69. doi Combined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma
    H B Kim
    Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea
    Clin Exp Allergy 38:774-80. 2008
    ..TNF-alpha and IL-13, two pivotal pro-inflammatory cytokines, are increased in asthmatic airways and may be linked to asthma susceptibility and/or bronchial hyperresponsiveness (BHR)...
  70. ncbi Mechanical stretch and angiotensin II increase interleukin-13 production and interleukin-13 receptor alpha2 expression in rat neonatal cardiomyocytes
    Yuki Nishimura
    Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan
    Circ J 72:647-53. 2008
    ..Recently, IL-13Ralpha2 has been considered as a therapeutic target for fibrosis and tumor growth. However, the mechanism of IL-13Ralpha2 expression in cardiomyocytes is unclear...
  71. doi Increased expression of Interleukin-13 and connective tissue growth factor, and their potential roles during foreign body encapsulation of subcutaneous implants
    W Kenneth Ward
    Legacy Health System, 1225 NE 2nd Avenue, Portland, OR 97232, USA
    J Biomater Sci Polym Ed 19:1065-72. 2008
    ....
  72. doi Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer, and its expression correlates with a propensity for lymph node metastases
    Andrea Formentini
    Clinic of General, Visceral, and Transplantation Surgery, University of Ulm, Steinhoevelstrasse 9, 89075, Ulm, Germany
    Int J Colorectal Dis 24:57-67. 2009
    ..It is not known whether pancreatic cancer cells produce IL-13 or whether IL-13 can modulate pancreatic cancer cell growth and influence the frequency of lymph node metastases...
  73. pmc Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury
    J Cortijo
    Department of Pharmacology, University of Valencia, Spain
    Br J Pharmacol 156:534-44. 2009
    ..The effects of a phosphodiesterase 4 (PDE4) inhibitor, roflumilast, on bleomycin-induced lung injury were explored in 'preventive' and 'therapeutic' protocols and compared with glucocorticoids...
  74. ncbi [Correlation of IL-4 and IL-13 gene polymorphisms with asthma and total serum IgE levels]
    Xiu Hai Wang
    Department of Biology, Qingdao University Medical College, Qingdao 266021, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:161-4. 2009
    ....
  75. ncbi [Interleukin-4 and interleukin-13 concentrations in bronchoalveolar lavage fluid in neonates with respiratory distress syndrome and concurrent ventilator-associated pneumonia]
    Yao Fang Xia
    Department of Neonatology, Hebei Province Children s Hospital, Shijiazhuang, China
    Zhongguo Dang Dai Er Ke Za Zhi 11:645-8. 2009
    ..To study the concentrations of IL-4 and IL-13 in bronchoalveolar lavage fluid (BALF) in neonates with respiratory distress syndrome (RDS) and concurrent ventilator-associated pneumonia (VAP)...
  76. pmc Elastase- and LPS-exposed mice display altered responses to rhinovirus infection
    Umadevi Sajjan
    Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 W Medical Center Dr, Rm 3570, MSRBII, Box 5688, Ann Arbor, MI 48109 5688, USA
    Am J Physiol Lung Cell Mol Physiol 297:L931-44. 2009
    ..Similar mechanisms may be operative in COPD...
  77. pmc Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection
    Aditya V Jain
    Department of Veteran s Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
    Infect Immun 77:5389-99. 2009
    ..Taken together, the data show that C. neoformans can significantly affect airflow physiology, particularly in the context of a Th2 immune response with possible involvement of IgE as an important factor...
  78. doi IL-13-induced oxidative stress via microglial NADPH oxidase contributes to death of hippocampal neurons in vivo
    Keun W Park
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Project Center, School of Medicine Kyung Hee University, Seoul 130 701, South Korea
    J Immunol 183:4666-74. 2009
    ..To our knowledge, the present study is the first to show that IL-13 triggers microglial NADPH oxidase-derived oxidative stress, leading to the degeneration of hippocampal neurons in vivo, as occurs in cases of Alzheimer's disease...
  79. doi Involvement of IL-13 in tobacco smoke-induced changes in the structure and function of rat intrapulmonary airways
    Philip R Cooper
    Section of Airway Disease, National Heart and Lung Institute, London UK
    Am J Respir Cell Mol Biol 43:220-6. 2010
    ..Chronic TS exposure induces increased responsiveness in intrapulmonary airways of rats that may be mediated in part by an increase in IL-13...
  80. pmc Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin M S B 5 278, Houston, TX 77030, USA
    Arthritis Res Ther 11:R147. 2009
    ..The current report sought to determine whether plasma cytokine profiles differ in SSc patients grouped according to these SSc-associated autoantibody subsets...
  81. doi Il13 promoter (-1055) polymorphisms associated with chronic obstructive pulmonary disease in Taiwanese
    Shih Feng Liu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Exp Lung Res 35:807-16. 2009
    ..007), but not associated with serum IL-13. In conclusion, IL13 -1055 T allele is associated with the development and severity of COPD in Taiwanese smokers...
  82. pmc Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
    Jesus F Bermejo-Martin
    National Centre of Influenza, Hospital Clinico Universitario de Valladolid, Valladolid, Spain
    Crit Care 13:R201. 2009
    ..We utilize here systemic cytokine and antibody levels in evaluating differences in early immune response in both mild and severe patients infected with nvH1N1...
  83. pmc Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent
    Mark S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:535-52. 2010
    ..Together, these studies identify a critical role for IL-17A in fibrosis, illustrating the potential utility of targeting IL-17A in the treatment of drug and inflammation-induced fibrosis...
  84. pmc IL-13 Gene Polymorphisms are Associated With Rhinosinusitis and Eosinophilic Inflammation in Aspirin Intolerant Asthma
    Nami Shrestha Palikhe
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    Allergy Asthma Immunol Res 2:134-40. 2010
    ..IL-13 plays a crucial role in the development of allergic asthma by inducing airway eosinophilia and hyper-reactivity and it has been correlated with an increased eosinophil count...
  85. ncbi [Serum levels of IL-13 and TNF-alpha in children with Mycoplasma pneumoniae pneumonia]
    Yin Fang Li
    Department of Pediatrics, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China
    Zhongguo Dang Dai Er Ke Za Zhi 12:275-7. 2010
    ..To examine serum levels of interleukin-13 (IL-13) and tumor necrosis factor alpha (TNF-alpha) in children with Mycoplasma pneumoniae (MP) pneumonia...
  86. doi Direct effects of IL-4/IL-13 and the nematode Nippostrongylus brasiliensis on intestinal epithelial cells in vitro
    K Takeda
    Department of Medical Zoology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Parasite Immunol 32:420-9. 2010
    ..These results suggested that HS3ST1 gene expression is strictly regulated by IL-4/IL-13, while ST3GalIV and MUC2 gene expressions are regulated by redundant mechanisms...
  87. pmc IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway
    Li Zuo
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 185:660-9. 2010
    ..Notably, we identified a pathway that induces EE-like changes and is IL-13-driven, eosinophil-independent, and suppressed by IL-13Ralpha2...
  88. doi Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis
    Marylène Fortin
    Topigen Pharmaceuticals Inc Pharmaxis Ltd Group, 2901 East Rachel Street, Montreal, Quebec, Canada
    Cytokine 52:194-202. 2010
    ..This study was therefore aimed at characterizing the spatio-temporal expression pattern of βc and CCR3 using a rat model of AR...
  89. pmc Release of B cell-activating factor of the TNF family in bronchoalveolar lavage from Behçet's disease with pulmonary involvement
    Agnes Hamzaoui
    Abderrahmen Mami Hospital, Ariana, Tunisia
    Oxid Med Cell Longev 3:122-8. 2010
    ..659, P<0.001].The antigen-induced production of BAFF in the lung of active BD with pulmonary manifestations might contribute to immunoglobulin synthesis by B cells. The cells residing in the lung might affect each other through BAFF...
  90. doi Th2-biased immune responses are important in a murine model of chronic hypersensitivity pneumonitis
    Keiko Mitaka
    Department of Integrated Pulmonology, Tokyo Medical and Dental University, Tokyo, Japan
    Int Arch Allergy Immunol 154:264-74. 2011
    ..A study was undertaken to evaluate whether Th2-biased immune responses were crucial during the processes of lung fibrosis in a murine model of chronic HP...
  91. doi LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia
    Ferenc G Rick
    Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Miami, Florida 33125, USA
    Prostate 71:736-47. 2011
    ..We investigated the mechanism of action and effect of Cetrorelix in a rat model of BPH...
  92. doi IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-β-independent Smad signaling
    Yan Liu
    Molecular Hepatology Alcohol Associated Diseases, II Medical Clinic Faculty of Medicine at Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    J Immunol 187:2814-23. 2011
    ..These results provide an improved new insight into the molecular mechanisms of profibrotic IL-13 activities in the liver...
  93. pmc Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease
    Kei Takahashi
    Inflammation Program, Dept, of Immunology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, 260 8670, Japan
    Pediatr Rheumatol Online J 9:30. 2011
    ..In addition, IL-1α, TNF-α, IL-10, IL-13, and MIP-1α were suppressed by treatment in the IgG group...
  94. doi Analysis of proinflammatory and anti-inflammatory cytokine serum concentrations in patients with multiple sclerosis by using a multiplexed immunoassay
    Thomas B Martins
    ARUP Institute for Clinical and Experimental Pathology, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    Am J Clin Pathol 136:696-704. 2011
    ....
  95. pmc Interleukin-4 (IL-4) and IL-13 suppress excessive neutrophil infiltration and hepatocyte damage during acute murine schistosomiasis japonica
    Takenori Seki
    Section of Environmental Parasitology, Tokyo Medical and Dental University Graduate School of Medical and Dental Science, Tokyo, Japan
    Infect Immun 80:159-68. 2012
    ..However, neutrophil induction and the production of proinflammatory cytokines were not due solely to IL-17A...
  96. ncbi Cloning of rat interleukin-13 (IL-13) cDNA and analysis of IL-13 gene expression in experimental glomerulonephritis
    F G Lakkis
    Renal Division, Emory University School of Medicine, Atlanta, Georgia
    Biochem Biophys Res Commun 197:612-8. 1993
    ..The data suggest a role for IL-13 in the inflammatory response in vivo...
  97. ncbi Interleukin-4 and -13 promote basolateral secretion of H(+) and cathepsin L by glomerular epithelial cells
    José G Van Den Berg
    Department of Pathology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Renal Physiol 282:F26-33. 2002
    ..We speculate that IL-4 and IL-13 influence intracellular trafficking of proteins and promote proteolysis at the basolateral surface of GVEC, which may play a pathogenic role in altered glomerular permeability...
  98. ncbi Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo
    Won Ho Shin
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Glia 46:142-52. 2004
    ..Our data strongly suggest that IL-13 may control brain inflammation by inducing the death of activated microglia in vivo, resulting in an enhancement of neuronal survival...
  99. ncbi Interleukin-25 and interleukin-13 production by alveolar macrophages in response to particles
    Chun Mi Kang
    Division of Allergy and Respiratory Diseases, Department of Internal Medicine, Soonchunhyang University Hospital, 1174 Jung dong, Wonmi gu, Bucheon si, Gyeonggido 420 767, Republic of Korea
    Am J Respir Cell Mol Biol 33:290-6. 2005
    ..These findings indicate that alveolar macrophages play an important role in particle-induced lung inflammation via direct induction of IL-13 and IL-25 production...

Research Grants2

  1. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  2. Alcohol abuse exacerbates bronchiolitis obliterans
    Patrick Mitchell; Fiscal Year: 2007
    ..This proposal has three overall goals: (1) to determine the effect of donor ethanol ingestion on OB; (2) to investigate the role of GMCSF; and (3) to investigate the role of TGFbeta1 in the pathogenesis of experimental-induced OB. ..