Kcnma1

Summary

Gene Symbol: Kcnma1
Description: potassium calcium-activated channel subfamily M alpha 1
Alias: BKCa, KCNMA1b, KCNMA1c, Kcnma, Slo, cbv1, calcium-activated potassium channel subunit alpha-1, BK channel, BKCA alpha, KCa1.1, calcium-activated potassium channel alpha subunit, calcium-activated potassium channel, subfamily M subunit alpha-1, k(VCA)alpha, maxi K channel, maxiK, potassium channel, calcium activated large conductance subfamily M alpha, member 1, potassium large conductance calcium-activated channel, subfamily M, alpha member 1, slo homolog, slo-alpha, slo1, slowpoke homolog
Species: rat

Top Publications

  1. ncbi Decreased expression of voltage- and Ca(2+)-activated K(+) channels in coronary smooth muscle during aging
    J Marijic
    Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA 90095 7115, USA
    Circ Res 88:210-6. 2001
  2. pmc Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy
    Boris S Ermolinsky
    Department of Biological Sciences, University of Texas at Brownsville Texas Southmost College, Brownsville, TX 78520, USA
    Neurosci Res 69:73-80. 2011
  3. doi Role of large-conductance Ca²+-activated K+ channels in adenosine A₁ receptor-mediated pharmacological postconditioning in H9c2 cells
    Laurice Fretwell
    Nottingham Trent University, Nottingham, UK
    Can J Physiol Pharmacol 89:24-30. 2011
  4. ncbi Control of alternative splicing of potassium channels by stress hormones
    J Xie
    Section of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    Science 280:443-6. 1998
  5. ncbi Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues
    T S Ha
    Department of Life Science, Kwangju Institute of Science and Technology, Korea
    Eur J Biochem 267:910-8. 2000
  6. ncbi Slo1 caveolin-binding motif, a mechanism of caveolin-1-Slo1 interaction regulating Slo1 surface expression
    Abderrahmane Alioua
    Department of Anesthesiology, Brain Research Institute, Cardiovascular Research Laboratories, UCLA, Los Angeles, CA 90095 1778, USA
    J Biol Chem 283:4808-17. 2008
  7. ncbi A novel MaxiK splice variant exhibits dominant-negative properties for surface expression
    M M Zarei
    Departments of Anesthesiology, Physiology, and Molecular and Medical Pharmacology and the Brain Research Institute, UCLA, Los Angeles, California 90095 7115, USA
    J Biol Chem 276:16232-9. 2001
  8. ncbi Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea
    Patricia Langer
    Institute of Physiology II, University of Tubingen, D 72076 Tubingen, Germany
    J Comp Neurol 455:198-209. 2003
  9. ncbi Beta1 (KCNMB1) subunits mediate lithocholate activation of large-conductance Ca2+-activated K+ channels and dilation in small, resistance-size arteries
    Anna N Bukiya
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Ave Memphis, TN 38163, USA
    Mol Pharmacol 72:359-69. 2007
  10. pmc Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels
    Jonathan H Jaggar
    Department of Physiology, University of Tennessee Health Science Center, Memphis 38139, USA
    Circ Res 97:805-12. 2005

Research Grants

  1. Regulation of Slo Splicing in the Urogenital Systme
    Kelvin Davies; Fiscal Year: 2006
  2. Solamere QLC100 Nipkow Spinning Disk Confocal Unit
    JONATHAN JAGGAR; Fiscal Year: 2007
  3. Vcsa1 (hSMR3A) as a Marker for Diabetes
    Kelvin Davies; Fiscal Year: 2008
  4. PKC Signaling in cAMP-Induced Pulmonary Vasodilation
    SCOTT BARMAN; Fiscal Year: 2010
  5. The Role of Vsca1 in Erectile Function
    Kelvin P Davies; Fiscal Year: 2010

Scientific Experts

  • Lijun Shi
  • Josef Zicha
  • Anna N Bukiya
  • Yan Wang
  • SCOTT BARMAN
  • Jonathan H Jaggar
  • Kelvin Paul Davies
  • Ru xing Wang
  • D D Denson
  • Sheng Nan Wu
  • Abderrahmane Alioua
  • Melissa A Riddle
  • Chul Seung Park
  • Lina Sun
  • Xiaoran Wang
  • Enrico Stefani
  • Ligia Toro
  • Benjimen R Walker
  • Jennifer M Hughes
  • Asser Nyander Poulsen
  • Guey Jen Lai
  • Meihua Chen
  • Hongya Hei
  • Ling Yu
  • Xue Jiao Wan
  • Jianxi Liu
  • Shanshan Zhou
  • Tingting Zhao
  • Liming Zhang
  • Guichun Yu
  • Zhanna V Vysotskaya
  • Jian Dong Ren
  • Zhencheng Li
  • Sulgi Kim
  • Sooyeon Jo
  • Fangmiao Jing
  • Harpreet Singh
  • Zhi Hu
  • D Iozzi
  • Bing Shen
  • Douglas C Eaton
  • Li Chen
  • Guodong Liu
  • E Coppi
  • Bjørn Olav Hald
  • Satish K Singh
  • Maria Maddalena Dinardo
  • Byoung Cheol Lee
  • Rong Lu
  • Boris S Ermolinsky
  • Laurice Fretwell
  • Soo Mi Park
  • Bai Yan Li
  • L C Burns
  • Guoxia Liu
  • Mansoureh Eghbali
  • Min Li
  • Juan Li
  • Guiling Zhao
  • Fang Sun
  • Eric Wersinger
  • Xiang Dong Tang
  • Jes Olesen
  • Dan Arne Klaerke
  • Inger Jansen-Olesen
  • Yu Wen Yang
  • Hiu Yee Kwan
  • Ju Ho Lee
  • Thomas J Bell
  • Thirumalini Vaithianathan
  • Jiusheng Yan
  • Helle Wulf
  • James S Trimmer
  • Kirk W Beisel
  • Bernd Fakler
  • Christina Kaldany Isacson
  • Richard W Aldrich
  • Christiana Dimitropoulou
  • Maria Asuncion-Chin
  • Uwe Schulte
  • Hyunyoung Kim
  • Wolfgang Bildl
  • Henrike Berkefeld
  • Hiroaki Misonou
  • Ning Zhu
  • Tal Soo Ha
  • Steven O Marx
  • Sandile E J Williams
  • Luxiang Cao
  • S F Mahmoud

Detail Information

Publications82

  1. ncbi Decreased expression of voltage- and Ca(2+)-activated K(+) channels in coronary smooth muscle during aging
    J Marijic
    Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA 90095 7115, USA
    Circ Res 88:210-6. 2001
    ..Because large-conductance voltage- and Ca(2+)-activated K(+) channels (MaxiK) are key regulators of vascular tone, we explored the possibility that this class of channels is diminished with ..
  2. pmc Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy
    Boris S Ermolinsky
    Department of Biological Sciences, University of Texas at Brownsville Texas Southmost College, Brownsville, TX 78520, USA
    Neurosci Res 69:73-80. 2011
    ..large conductance Ca(2+) activated potassium (BK) channels are determined by complex alternative splicing of the Kcnma1 gene encoding the alpha pore-forming subunit...
  3. doi Role of large-conductance Ca²+-activated K+ channels in adenosine A₁ receptor-mediated pharmacological postconditioning in H9c2 cells
    Laurice Fretwell
    Nottingham Trent University, Nottingham, UK
    Can J Physiol Pharmacol 89:24-30. 2011
    ..These results have shown for the first time that BK(Ca) channels are involved in adenosine A₁ receptor-induced pharmacological postconditioning in a cell model system...
  4. ncbi Control of alternative splicing of potassium channels by stress hormones
    J Xie
    Section of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    Science 280:443-6. 1998
    ..Expression of alternative splice variants of Slo, a gene encoding calcium- and voltage-activated potassium channels, was measured in rat adrenal chromaffin tissue ..
  5. ncbi Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues
    T S Ha
    Department of Life Science, Kwangju Institute of Science and Technology, Korea
    Eur J Biochem 267:910-8. 2000
    ..Ca2+-activated and voltage-activated K+ currents characteristic of neuronal large-conductance Ca2+-activated K+ (BKCa) channels...
  6. ncbi Slo1 caveolin-binding motif, a mechanism of caveolin-1-Slo1 interaction regulating Slo1 surface expression
    Abderrahmane Alioua
    Department of Anesthesiology, Brain Research Institute, Cardiovascular Research Laboratories, UCLA, Los Angeles, CA 90095 1778, USA
    J Biol Chem 283:4808-17. 2008
    The large conductance, voltage- and Ca2+-activated potassium (MaxiK, BK) channel and caveolin-1 play important roles in regulating vascular contractility...
  7. ncbi A novel MaxiK splice variant exhibits dominant-negative properties for surface expression
    M M Zarei
    Departments of Anesthesiology, Physiology, and Molecular and Medical Pharmacology and the Brain Research Institute, UCLA, Los Angeles, California 90095 7115, USA
    J Biol Chem 276:16232-9. 2001
    We identified a novel MaxiK alpha subunit splice variant (SV1) from rat myometrium that is also present in brain...
  8. ncbi Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea
    Patricia Langer
    Institute of Physiology II, University of Tubingen, D 72076 Tubingen, Germany
    J Comp Neurol 455:198-209. 2003
    ..Extensive splicing of BK channel transcripts, however, does not seem to be used in mammalian hair cells as is done in lower vertebrates.
  9. ncbi Beta1 (KCNMB1) subunits mediate lithocholate activation of large-conductance Ca2+-activated K+ channels and dilation in small, resistance-size arteries
    Anna N Bukiya
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Ave Memphis, TN 38163, USA
    Mol Pharmacol 72:359-69. 2007
    ..This study pinpoints the BK beta1 subunit as the molecule that senses LC, which results in myocyte BK channel activation and, thus, endothelial-independent relaxation of small, resistance-size arteries.
  10. pmc Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels
    Jonathan H Jaggar
    Department of Physiology, University of Tennessee Health Science Center, Memphis 38139, USA
    Circ Res 97:805-12. 2005
    ....
  11. doi Effects of age on expression of BKca channel in vascular smooth muscle cells from mesenteric arteries of spontaneously hypertensive rats
    Zhi Hu
    Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi an Jiaotong University Key Laboratory of Environmental and Gene Related Diseases Xi an Jiaotong University, Chinese Ministry of Education, No 277 West Yanta Road, Xi an, Shaanxi, 710061, China
    J Physiol Biochem 69:945-55. 2013
    ..However, changes in large conductance calcium-activated potassium (BKca) channel current density and channel protein composition during aging are not fully understood and are currently ..
  12. pmc BK Knockout by TALEN-Mediated Gene Targeting in Osteoblasts: KCNMA1 Determines the Proliferation and Differentiation of Osteoblasts
    Hongya Hei
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China
    Mol Cells 39:530-5. 2016
    ....
  13. pmc Orai1 forms a signal complex with BKCa channel in mesenteric artery smooth muscle cells
    Meihua Chen
    Department of Physiology, Anhui Medical University, Hefei, Anhui, China
    Physiol Rep 4:. 2016
    ....
  14. ncbi Myelin basic protein as a binding partner and calmodulin adaptor for the BKCa channel
    Hyunyoung Kim
    Department Life Science, Gwangju Institute of Science and Technology GIST, Gwangju, Korea
    Proteomics 7:2591-602. 2007
    The activity and localization of large-conductance Ca2+ -activated K+ (BKCa) channels are known to be modulated by several different proteins...
  15. pmc Unoprostone activation of BK (KCa1.1) channel splice variants
    Ling Yu
    College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China
    Biochim Biophys Acta 1848:2859-67. 2015
    ..We used HEK293 cells stably transfected with two BK channel splice variants, one sensitive to unoprostone and the other insensitive...
  16. pmc Protein-protein interaction between cPLA2 and splice variants of alpha-subunit of BK channels
    Juan Li
    Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 298:C251-62. 2010
    ....
  17. pmc Replication study of genome-wide associated SNPs with late-onset Alzheimer's disease
    L C Burns
    Department of Human Genetics, University of Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 156:507-12. 2011
    ..Significant associations were observed between AAO and ZNF224/rs3746319 (P = 0.002) and KCNMA1/rs16934131 (P = 0.0066)...
  18. pmc A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels
    Guodong Liu
    Department of Physiology, Faculty of Medicine, University of Manitoba, 745 Bannatyne Ave, Winnipeg, MB R3E 0J9, Canada
    J Biol Chem 287:22709-16. 2012
    ..Here we show that the regulation of the stress axis-regulated exon of the Slo1 potassium channel transcripts by membrane depolarization requires a highly conserved CaMKIV target serine (Ser-513) ..
  19. doi Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels
    D Iozzi
    Dipartimento di Scienze della Vita, Universita degli Studi di Siena, Siena, Italy
    Acta Physiol (Oxf) 208:329-39. 2013
    ..1) channels. Thus, the aim of the present investigation was to address the hypothesis that quercetin-induced vasorelaxation is caused by a PKG-mediated stimulation of KCa 1.1 currents...
  20. doi Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa
    Fangmiao Jing
    Department of Physiology, Shandong University School of Medicine, Jinan, China
    J Pharm Pharmacol 65:847-54. 2013
    ..This study investigated the effects of bitter compounds on the spontaneous contraction of longitudinal smooth muscle strips of rat ileum...
  21. doi A combination of genistein and magnesium enhances the vasodilatory effect via an eNOS pathway and BK(Ca) current amplification
    Lina Sun
    Department of Neurology, The First Affiliated Hospital of Harbin Medical University, 23 Post Street, Harbin, Heilongjiang 150001, P R China
    Can J Physiol Pharmacol 93:215-21. 2015
    ..Our data suggest that GST plus magnesium provides enhanced vasodilatory effects in rat mesenteric arteries compared with that observed when either is used separately, which was related to an eNOS pathway and BK(Ca) current amplification...
  22. doi Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of α- and β1-subunit expression
    Lijun Shi
    Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China Electronic address
    Mech Ageing Dev 134:416-25. 2013
    ..Large-conductance Ca(2+)-activated K(+)(MaxiK) channel, with pore-forming α-subunit and modulatory β1-subunit, is a key regulator of vascular tone...
  23. doi Effects of palmitoylation on the diffusional movement of BKCa channels in live cells
    Sulgi Kim
    School of Life Sciences, Gwangju Institute of Science and Technology GIST, Gwangju, Republic of Korea
    FEBS Lett 588:713-9. 2014
    b>BKCa channels are palmitoylated at a cluster of cysteine residues within the cytosolic linker connecting the 1st and 2nd transmembrane domains, and this lipid modification affects their surface expression...
  24. doi Mg²⁺-dependent modulation of BKCa channels by genistein in rat arteriolar smooth muscle cells
    Xiaoran Wang
    Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, PR China
    J Cell Physiol 229:1981-9. 2014
    ..The mechanism of this biphasic effects involves PTK-independent amplification and [Mg(2+)]i -PTK-dependent inhibition...
  25. doi Exercise training reverses alterations in Kv and BKCa channel molecular expression in thoracic aorta smooth muscle cells from spontaneously hypertensive rats
    Zhencheng Li
    Department of Exercise Physiology, Beijing Sport University, Beijing, China
    J Vasc Res 51:447-57. 2014
    ..alterations in voltage-gated potassium channels (Kv) and large-conductance, calcium-activated potassium channels (BKCa) in thoracic aorta smooth muscle cells from spontaneously hypertensive rats (SHRs)...
  26. doi Pharmacological blockade of the MaxiK channel attenuates experimental acute pancreatitis and associated lung injury in rats
    Jian Dong Ren
    Department of Pharmacy, Chengdu Military General Hospital, Chengdu, China Electronic address
    Int Immunopharmacol 21:220-4. 2014
    ..Our previous work has provided a valuable clue that a large-conductance K(+) channel (MaxiK) was involved in the HS-stimulated activation of murine macrophages...
  27. doi Modulation of BK channel activities by calcium-sensing receptor in rat bronchopulmonary sensory neurons
    Zhanna V Vysotskaya
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
    Respir Physiol Neurobiol 203:35-44. 2014
    ..of large-conductance Ca(2+)-activated potassium (BK) channels and to explore the possible modulation of BK channel activities by calcium-sensing receptors (CaSR) in rat bronchopulmonary sensory neurons...
  28. pmc Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4
    Anna N Bukiya
    From the Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163 and
    J Biol Chem 289:35314-25. 2014
    ..b>BK channel regulation by direct interaction between lipid and channel protein sites has received increasing attention...
  29. doi Involvement of BK channel in differentiation of vascular smooth muscle cells induced by mechanical stretch
    Xue Jiao Wan
    Institute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    Int J Biochem Cell Biol 59:21-9. 2015
    ..was significantly increased by 15% stretch and was accompanied by an increased alternative splicing of BK channel α-subunit at the stress axis-regulated exons (STREX)...
  30. pmc MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location
    Harpreet Singh
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 110:10836-41. 2013
    The large-conductance Ca(2+)- and voltage-activated K(+) channel (BK(Ca), MaxiK), which is encoded by the Kcnma1 gene, is generally expressed at the plasma membrane of excitable and nonexcitable cells...
  31. pmc Role of caveolin-1 in endothelial BKCa channel regulation of vasoreactivity
    Melissa A Riddle
    Vascular Physiology Group, Dept of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Cell Physiol 301:C1404-14. 2011
    ..We conclude that CH unmasks EC BK(Ca) channel activity by removing an inhibitory action of the Cav-1 scaffolding domain that may depend on cellular cholesterol levels...
  32. doi BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles
    Bjørn Olav Hald
    Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Pflugers Arch 463:279-95. 2012
    ..This finding is potentially relevant to understanding the compromised microcirculatory blood flow in systemic vascular diseases such as diabetes mellitus and hypertension...
  33. ncbi [Changes of BKCa during aging and its correlation with blood pressure]
    Yu Wen Yang
    Department of Cardiology of Yijishan Hospital, Wannan Medical College, Wuhu 241001, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 25:511-5. 2009
    To investigate the changes of large-conductance calcium-activated potassium channels (BKCa, MaxiK) during aging and relations between the changes and blood pressure.
  34. pmc P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices
    E Coppi
    Research Department of Neuroscience, Physiology and Pharmacology, University College London, United Kingdom
    J Neurophysiol 107:1009-21. 2012
    ..Therefore, P2Y(1) signaling leading to activation of I(K(Ca)) may be important in regulating the activity of medium-sized neurons in the striatum...
  35. pmc Aldosterone induces active K⁺ secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon
    Satish K Singh
    Department of Medicine, Boston University School of Medicine and Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    Am J Physiol Cell Physiol 302:C1353-60. 2012
    Although both Kcnn4c and Kcnma1 channels are present on colonic mucosal membranes, only Kcnma1 has been suggested to mediate K(+) secretion in the colon...
  36. doi Effect of exercise training volume on arterial contractility and BK(Ca) channel activity in rat thoracic aorta smooth muscle cells
    Lijun Shi
    Department of Exercise Physiology, Beijing Sport University, Beijing 100084, People s Republic of China
    Eur J Appl Physiol 112:3667-78. 2012
    ..These data suggest that there is a dose effect for exercise training volume for the activation of BK(Ca) channels in vascular SMCs, which contributes to improvement of the arterial function in thoracic aortas...
  37. pmc Regulation of endothelial BK channels by heme oxygenase-derived carbon monoxide and caveolin-1
    Melissa A Riddle
    Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, USA
    Am J Physiol Cell Physiol 303:C92-C101. 2012
    ..We conclude that EC BK channel activity is HO dependent in the absence of the inhibitory effect of the Cav-1 scaffolding domain.
  38. doi Contribution of BK(Ca) channels of neurons in rostral ventrolateral medulla to CO-mediated central regulation of respiratory rhythm in medullary slices of neonatal rats
    Li Chen
    Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, PR China
    Respir Physiol Neurobiol 182:93-9. 2012
    ..Altogether, these data indicate that BK(Ca) channels of the neurons in neonatal rostral ventrolateral medulla could be activated by CO and involved in CO-mediated central regulation of respiratory rhythm in medullary slices...
  39. pmc Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells
    Guiling Zhao
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Gen Physiol 136:283-91. 2010
    ..In summary, data indicate that IP(3)R1 activation elevates BK(Ca) channel apparent Ca(2+) sensitivity through local molecular coupling in arterial smooth muscle cells...
  40. pmc Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle
    Maria Maddalena Dinardo
    Departments of Pharmacobiology, Faculty of Pharmacy, University of Bari, Bari, Italy
    PLoS ONE 7:e40235. 2012
    ..Patch-clamp experiments combined with transcript scanning of the Kcnma1 gene encoding the alpha subunit of the BK channel were performed in rat slow-twitch soleus (Sol) and fast-twitch flexor digitorum brevis (FDB) skeletal muscles...
  41. ncbi Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2⁺-activated K⁺ channel impairment
    Ru xing Wang
    Department of Cardiology, Wuxi People s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, China
    Chin Med J (Engl) 125:2548-55. 2012
    ..The purpose of this study is to determine the role of vascular large conductance Ca(2+)-activated K(+) (BK) channel activities in coronary dysfunction in streptozotocin-induced diabetic rats...
  42. pmc Steady-state and closed-state inactivation properties of inactivating BK channels
    Jiu Ping Ding
    Washington University School of Medicine, Department of Anesthesiology, St Louis, Missouri 63110, USA
    Biophys J 82:2448-65. 2002
    ..voltage-dependent K+ channels in chromaffin cells exhibit an inactivation that probably arises from coassembly of Slo1 alpha subunits with auxiliary beta subunits...
  43. ncbi Increased expression of Ca2+-sensitive K+ channels in aorta of hypertensive rats
    Y Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 30:1403-9. 1997
    ....
  44. ncbi Identification and localization of Ca(2+)-activated K+ channels in rat sciatic nerve
    H Mi
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, California 94305, USA
    Glia 26:166-75. 1999
    ..In the present study, we examined the slo family of Ca(2+)-activated K+ channels, a class of channel that had not previously been identified in myelinated ..
  45. ncbi Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release
    H Hu
    Institute of Physiology, University of Oslo, Blindern, N 0317 Oslo, Norway
    J Neurosci 21:9585-97. 2001
    ..Double-labeling immunogold analysis with BK channel and glutamate receptor antibodies indicated that BK channels are targeted to the presynaptic membrane facing the ..
  46. ncbi Properties of large conductance calcium-activated potassium channels in pyramidal neurons from the hippocampal CA1 region of adult rats
    L W Gong
    Department of Physiology, The First Military Medical University, Guangzhou, 510515, China
    Jpn J Physiol 51:725-31. 2001
    ....
  47. ncbi Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels
    Lynne J Shanley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Nat Neurosci 5:299-300. 2002
  48. ncbi Nitric oxide enhances Ca(2+)-dependent K(+) channel activity in rat carotid body cells
    Jeane M Silva
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 2300, USA
    Pflugers Arch 443:671-5. 2002
    ....
  49. pmc Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor
    Guoxia Liu
    Division of Cardiology and Center for Molecular Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    EMBO J 23:2196-205. 2004
    Large-conductance voltage and Ca2+-activated potassium channels (BKCa) play a critical role in modulating contractile tone of smooth muscle, and neuronal processes...
  50. ncbi Diminished surface clustering and increased perinuclear accumulation of large conductance Ca2+-activated K+ channel in mouse myometrium with pregnancy
    Mansoureh Eghbali
    Department of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1778, USA
    J Biol Chem 278:45311-7. 2003
    ..However, in rats, the main mechanism for the reduced channel expression at the cell surface is a diminished transcription, whereas in mice, it is an altered traffic to the surface...
  51. pmc Opposing actions of adrenal androgens and glucocorticoids on alternative splicing of Slo potassium channels in bovine chromaffin cells
    Guey Jen Lai
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 99:7722-7. 2002
    ..a precipitous change in the relative abundance of two alternative splice variants of the "BK"- or "Maxi K"-encoding Slo gene in adrenal chromaffin cells...
  52. ncbi cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase
    Scott A Barman
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1004-11. 2003
    ....
  53. pmc Stimulatory action of internal protons on Slo1 BK channels
    Vladimir Avdonin
    Department of Pharmacology, College of Medicine, The University of Iowa, Iowa City 52242, USA
    Biophys J 84:2969-80. 2003
    ..These results indicate that the acid-sensitivity of the Slo BK channel may involve the channel domain implicated in the divalent-dependent activation.
  54. pmc Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel
    Tal Soo Ha
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju, 500 712, Korea
    Biophys J 86:2871-82. 2004
    ..To understand the physiological roles of the beta4-subunit on the BK(Ca) channel alpha-subunit (Slo), we isolated a full-length complementary DNA of rat beta4-subunit (rbeta4), expressed heterolgously in Xenopus ..
  55. ncbi Regulation of Slo potassium channel alternative splicing in the pituitary by gonadal testosterone
    S F Mahmoud
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    J Neuroendocrinol 16:237-43. 2004
    b>Slo gene-encoded BK potassium channels are prominent in both adrenomedullary and pituitary tissues. At one alternative splicing site, both tissues express variants with and without the optional 'STREX' exon...
  56. pmc KCa1.1 channel contributes to cell excitability in unmyelinated but not myelinated rat vagal afferents
    Bai Yan Li
    Dept of Biomedical Engineering, Indiana University Purdue University, 723 W Michigan St, Indianapolis, IN 46202, USA
    Am J Physiol Cell Physiol 300:C1393-403. 2011
    ....
  57. ncbi Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels
    Xiang Dong Tang
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 425:531-5. 2003
    ..This direct regulation of the BK channel identifies a previously unknown role of haem as an acute signalling molecule.
  58. pmc Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity
    Jiusheng Yan
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, California 95616, USA
    Mol Cell Proteomics 7:2188-98. 2008
    ....
  59. ncbi Regulation of alternative splicing of Slo K+ channels in adrenal and pituitary during the stress-hyporesponsive period of rat development
    Guey Jen Lai
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    Endocrinology 147:3961-7. 2006
    ..Previous evidence indicates that pituitary and steroid hormones regulate alternative splicing of the Slo gene at the stress axis-regulated exon (STREX), with functional implications for the calcium-activated K+ channels ..
  60. ncbi Co-localization of the alpha-subunit of BK-channels and c-PLA2 in GH3 cells
    D D Denson
    Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 350:39-49. 2006
    ..of the BK-channel was strongly co-immunoprecipitated by c-PLA2 antibodies, suggesting that most of the BK channel alpha-subunits are associated with c-PLA2...
  61. ncbi BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling
    Henrike Berkefeld
    Institute of Physiology, University of Freiburg, Hermann Herder Strasse 7, 79104 Freiburg, Germany
    Science 314:615-20. 2006
    Large-conductance calcium- and voltage-activated potassium channels (BKCa) are dually activated by membrane depolarization and elevation of cytosolic calcium ions (Ca2+)...
  62. ncbi Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells
    Kirk W Beisel
    Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Gene 386:11-23. 2007
    ..These channels are thought to play a role in the tonotopic gradient observed in the mammalian cochlea. Mouse Kcnma1 transcripts, 5' and 3' ESTs, and genomic sequences were examined for the utilization of alternative splicing in ..
  63. pmc Diabetes-induced changes in the alternative splicing of the slo gene in corporal tissue
    Kelvin P Davies
    Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Eur Urol 52:1229-37. 2007
    Erectile dysfunction is a common diabetic complication. Preclinical studies have documented that the Slo gene (encoding the BK or Maxi-K channel alpha-subunit) plays a critical role in erectile function...
  64. ncbi RACK1 is a BKCa channel binding protein
    Christina Kaldany Isacson
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Physiol Cell Physiol 292:C1459-66. 2007
    ..Thus RACK1 binds to the BK(Ca) channel and it may form part of a BK(Ca)-channel regulatory complex in vascular smooth muscle...
  65. ncbi Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation
    Christiana Dimitropoulou
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, USA
    Prostaglandins Other Lipid Mediat 83:50-61. 2007
    ..These findings provide initial evidence that PP2A activity contributes to 11,12-EET and 11,12-EET analog activation of mesenteric resistant artery BK(Ca) channels and vasorelaxation...
  66. pmc CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels
    Jianxi Liu
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, Tennessee 38163, USA
    Nat Neurosci 9:41-9. 2006
    ..We identified Thr107 of bovine slo (bslo) in this loop as a critical residue that determines BK channel responses to alcohol...
  67. ncbi Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy
    Ning Zhu
    Department of Anesthesiology, Division of Molecular Medicine, University of California Los Angeles, Los Angeles, CA 90095 7115, USA
    FEBS Lett 579:4856-60. 2005
    STREX alternative-exon adds to Slo channel a phosphorylation sequence that can invert protein kinase A (PKA) regulation from excitatory to inhibitory...
  68. ncbi Stimulatory actions of di-8-butyl-amino-naphthyl-ethylene-pyridinium-propyl-sulfonate (di-8-ANEPPS), voltage-sensitive dye, on the BKCa channel in pituitary tumor (GH3) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1, University Road, Tainan 70101 Taiwan, Republic of China
    Pflugers Arch 455:687-99. 2008
    ..Taken together, this study suggests that during the exposure to di-8-ANEPPS, the stimulatory effects on BK(Ca) channels could be one of potential mechanisms through which it may affect cell excitability...
  69. ncbi Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain
    Sooyeon Jo
    Department of Life Science, Gwangju Institute Science and Technology GIST, Gwangju, Republic of Korea
    J Neurochem 94:1212-24. 2005
    ..the direct interaction of cereblon (CRBN) with the cytosolic carboxy-terminus of the BK(Ca) channel alpha subunit (Slo)...
  70. pmc Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons
    Thomas J Bell
    Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:1901-6. 2008
    ..These data suggest a new regulatory mechanism for modulating the membrane properties and ion channel gradients of hippocampal neurons...
  71. pmc Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway
    Thirumalini Vaithianathan
    Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Gen Physiol 132:13-28. 2008
    ..C (PLC)-generated PIP(2) metabolites that target Ca(2+) stores and protein kinase C and, eventually, the BK channel. Here, we report that PIP(2) activates BK channels independently of PIP(2) metabolites...
  72. ncbi Direct interaction between BKCa potassium channel and microtubule-associated protein 1A
    Soo Mi Park
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    FEBS Lett 570:143-8. 2004
    The BKCa channel, a potassium channel that is allosterically activated by voltage and calcium, is expressed in both excitable and non-excitable cells. The channel plays an important role in regulating membrane excitability...
  73. doi Molecular studies of BKCa channels in intracranial arteries: presence and localization
    Helle Wulf
    Department of Neurology and Danish Headache Centre, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 69, 2600, Glostrup, Denmark
    Cell Tissue Res 334:359-69. 2008
    ..The data thus suggest the presence and localization of both mRNA and protein expression of the BK(Ca) channel in the smooth muscle cell layer in rat basilar, middle cerebral, and middle meningeal arteries...
  74. doi TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells
    Hiu Yee Kwan
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and Department of Physiology, The Chinese University of Hong Kong, Hong Kong, China
    Circ Res 104:670-8. 2009
    ..The hyperpolarizing effect of TRPC1-BK(Ca) coupling could serve to reduce agonist-induced membrane depolarization, thereby preventing excessive contraction of VSMCs to contractile agonists...
  75. pmc Modulation of the conductance-voltage relationship of the BK(Ca) channel by shortening the cytosolic loop connecting two RCK domains
    Ju Ho Lee
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea
    Biophys J 97:730-7. 2009
    ..Thus, the functional activity of the BK(Ca) channel can be modulated by altering the tension of this loop region...
  76. ncbi Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel
    Sandile E J Williams
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Science 306:2093-7. 2004
    ..We demonstrate that hemoxygenase-2 (HO-2) is part of the BK channel complex and enhances channel activity in normoxia...
  77. pmc Novel role of endothelial BKCa channels in altered vasoreactivity following hypoxia
    Jennifer M Hughes
    Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Am J Physiol Heart Circ Physiol 299:H1439-50. 2010
    ..IBTX was without effect on K(+) current in controls. We conclude that hypobaric CH induces increased endothelial BK(Ca) channel activity that contributes to reduced myogenic responsiveness and EC and VSM cell hyperpolarization...
  78. doi The role of the large-conductance voltage-dependent and calcium-activated potassium (BK(Ca)) channels in the regulation of rat ductus arteriosus tone
    Fang Sun
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Heart Vessels 25:556-64. 2010
    ..Activation of BK(Ca) channels led to vasodilatation in the preconstricted DA induced by O₂, possibly suggesting a way to maintain the patency of DA after birth...
  79. doi Neuronal fast activating and meningeal silent modulatory BK channel splice variants cloned from rat
    Asser Nyander Poulsen
    Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 7, Frederiksberg C, Denmark
    Pflugers Arch 461:65-75. 2011
    ..X1 variant may be important for a subpopulation of BK channels in the brain, while the "silent" truncated variants X2(92) and X2(188) may play a role as modulators of other BK channel variants in a way similar to well known beta subunits.
  80. pmc Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation
    Min Li
    Department of Anesthesiology, and Brain Research Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:19096-101. 2010
    Large conductance voltage- and calcium-activated potassium channels (MaxiK, BK(Ca)) are well known for sustaining cerebral and coronary arterial tone and for their linkage to vasodilator β-adrenergic receptors...
  81. pmc BK channels mediate cholinergic inhibition of high frequency cochlear hair cells
    Eric Wersinger
    Department of Otolaryngology Head and Neck Surgery, Center for Hearing and Balance, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e13836. 2010
    ..The objectives of this study were to investigate the tonotopic contribution of BK channels to voltage- and ligand-gated currents in mature outer hair cells from the rat cochlea...
  82. pmc Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, University of California, Davis, 95616, USA
    J Comp Neurol 496:289-302. 2006
    Ca(2+)-activated voltage-dependent K(+) channels (Slo1, KCa1.1, Maxi-K, or BK channel) play a crucial role in controlling neuronal signaling by coupling channel activity to both membrane depolarization and intracellular Ca(2+) signaling...

Research Grants5

  1. Regulation of Slo Splicing in the Urogenital Systme
    Kelvin Davies; Fiscal Year: 2006
    ..in urogenital physiology this research project will investigate the effect of hormones on splicing of the Slo gene in urogenital smooth muscle tissue in vivo and in vitro...
  2. Solamere QLC100 Nipkow Spinning Disk Confocal Unit
    JONATHAN JAGGAR; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Vcsa1 (hSMR3A) as a Marker for Diabetes
    Kelvin Davies; Fiscal Year: 2008
    ..The final aim will be to determine expression levels of hSMR3A protein from diabetic and non-diabetic patients (in saliva, blood and corporal samples) as an indicator of vascular health. [unreadable] [unreadable] [unreadable]..
  4. PKC Signaling in cAMP-Induced Pulmonary Vasodilation
    SCOTT BARMAN; Fiscal Year: 2010
    ..Activation of large-conductance, calcium- and voltage-activated potassium (BKCa) channels is important in the regulation of pulmonary arterial pressure and inhibition of BKCa channels has been ..
  5. The Role of Vsca1 in Erectile Function
    Kelvin P Davies; Fiscal Year: 2010
    ..Vcsal/hSMR3A expression might also be used as a non-subjective marker of erectile function. ..