Panx1

Summary

Gene Symbol: Panx1
Description: Pannexin 1
Alias: px1, pannexin-1
Species: rat

Top Publications

  1. pmc Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    Pablo Pelegrin
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    EMBO J 25:5071-82. 2006
  2. doi ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors
    M Alexandrina Timóteo
    Laboratório de Farmacologia e Neurobiologia UMIB, Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto ICBAS UP, Porto, Portugal
    Biochem Pharmacol 87:371-9. 2014
  3. pmc The pannexin 1 channel activates the inflammasome in neurons and astrocytes
    William R Silverman
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 284:18143-51. 2009
  4. pmc Pannexin 1 constitutes the large conductance cation channel of cardiac myocytes
    Marie Cecile Kienitz
    Department of Cellular Physiology, Ruhr University Bochum, 44780 Bochum, Germany
    J Biol Chem 286:290-8. 2011
  5. pmc P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP
    Min Zhang
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario L8S 4K1, Canada
    J Physiol 590:4335-50. 2012
  6. pmc Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels
    Shuo Li
    Section on Cellular Signaling, Program in Developmental Neuroscience, NICHD, National Institutes of Health, Bethesda, MD 20892 4510, USA
    Gen Comp Endocrinol 174:202-10. 2011
  7. doi The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF
    Irma Lemaire
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Immunol 187:3878-87. 2011
  8. doi P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 301:H881-7. 2011
  9. pmc Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain
    Jonathan M Beckel
    Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Glia 62:1486-501. 2014
  10. pmc Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling
    Hiromitsu Negoro
    Department of Urology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 9:e106269. 2014

Scientific Experts

  • Donald A Vessey
  • Roger J Thompson
  • Shuo Li
  • Irma Lemaire
  • Daniela Boassa
  • Marie Cecile Kienitz
  • Jonathan M Beckel
  • Nicholas L Weilinger
  • Dale W Laird
  • Julie Dufresne
  • Silvia Penuela
  • Qing Shao
  • Gerhard Dahl
  • Yuhao Zhang
  • James A Angus
  • Abraham Cisneros-Mejorado
  • Claire H Mitchell
  • Hiromitsu Negoro
  • M Alexandrina Timóteo
  • Daniel G Cyr
  • Feng Xiao
  • Eliana Scemes
  • Alan R Burns
  • Min Zhang
  • Patrick Turmel
  • Sadahiro Iwabuchi
  • Ruchi Gehi
  • Cinzia Ambrosi
  • Valery I Shestopalov
  • Masahito Kawamura
  • Steven J Celetti
  • Ruchi Bhalla-Gehi
  • Xiao Hui Wang
  • Stefanie Bunse
  • Silviu Locovei
  • Feng Qiu
  • William R Silverman
  • Galina Dvoriantchikova
  • Pablo Pelegrin
  • Travis Rilea
  • Brooke D Rakai
  • Nathan T Ikuta
  • Ian R Winship
  • Mischa V Bandet
  • Roberto Bruzzone
  • Jennifer Bialecki
  • Alexander W Lohman
  • G Campbell Teskey
  • Lucas Scott
  • Michael A Colicos
  • Evelyn M M Ma
  • Valentyna Maslieieva
  • Christine E Wright
  • Hui Lin Pan
  • Tim Magnus
  • Alberto Pérez-Samartín
  • Walter N Hittelman
  • William C de Groat
  • Lori A Birder
  • Amanda S Wolf-Johnston
  • Pradeep Tyagi
  • Carlos Matute
  • Fabio Cavaliere
  • Geoffroy Laumet
  • Miroslav Gottlieb
  • Ashenafi H Betrie
  • Friederich Koch-Nolte
  • Stephanie L Daugherty
  • Shao Rui Chen
  • Inês Carneiro
  • Edward J Macarak
  • Mia M Thi
  • Louis S Liou
  • Paulo Correia-de-Sá
  • Miguel Silva-Ramos
  • Arthur J Argall
  • Jason C Lim
  • Nicholas A Delamere
  • Marcia Urban-Maldonado
  • Val C Sheffield
  • José Bernardo Noronha-Matos
  • Alan M Laties
  • Sylvia O Suadicani
  • David C Spray
  • Isabel Silva
  • Jingsheng Xia
  • Fatima Ferreirinha
  • Erin E Coffey
  • Mohammed Shahidullah
  • Wennan Lu

Detail Information

Publications36

  1. pmc Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    Pablo Pelegrin
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    EMBO J 25:5071-82. 2006
    ....
  2. doi ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors
    M Alexandrina Timóteo
    Laboratório de Farmacologia e Neurobiologia UMIB, Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto ICBAS UP, Porto, Portugal
    Biochem Pharmacol 87:371-9. 2014
    ..Data indicate that activation of P2Y6 receptors causes bladder overactivity in the anaesthetized rat indirectly by releasing ATP from the urothelium via pannexin-1 hemichannels. ..
  3. pmc The pannexin 1 channel activates the inflammasome in neurons and astrocytes
    William R Silverman
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 284:18143-51. 2009
    ..In primary macrophages, potassium ion flux and the membrane channel pannexin 1 have been suggested to play roles in inflammasome activation...
  4. pmc Pannexin 1 constitutes the large conductance cation channel of cardiac myocytes
    Marie Cecile Kienitz
    Department of Cellular Physiology, Ruhr University Bochum, 44780 Bochum, Germany
    J Biol Chem 286:290-8. 2011
    ..A potential candidate for this channel is pannexin 1 (Panx1), which has been shown to form large ion channels when expressed in Xenopus oocytes and mammalian cells...
  5. pmc P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP
    Min Zhang
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario L8S 4K1, Canada
    J Physiol 590:4335-50. 2012
    ..We propose that CB type II cells may function as ATP amplifiers during chemotransduction via paracrine activation of P2Y2Rs and Panx-1 channels...
  6. pmc Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels
    Shuo Li
    Section on Cellular Signaling, Program in Developmental Neuroscience, NICHD, National Institutes of Health, Bethesda, MD 20892 4510, USA
    Gen Comp Endocrinol 174:202-10. 2011
    Our previous studies have showed that Pannexin 1 (Panx1), a member of a recently discovered family of gap junction proteins, is expressed in the pituitary gland...
  7. doi The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF
    Irma Lemaire
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Immunol 187:3878-87. 2011
    ..These data demonstrate that both P2X(7) and Panx-1 are required for GM-CSF promotion of MA fusion but likely act independently through different signaling pathway(s)...
  8. doi P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 301:H881-7. 2011
    ..The data point out for the first time the potential of P2X(7) agonists as cardioprotectants...
  9. pmc Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain
    Jonathan M Beckel
    Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Glia 62:1486-501. 2014
    ..genes for panx1, panx2, and panx3 were increased, whereas immunohistochemistry confirmed increased expression of pannexin 1 protein...
  10. pmc Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling
    Hiromitsu Negoro
    Department of Urology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 9:e106269. 2014
    ..In other cell types, pannexin 1 (Panx1) channels provide a pathway for mechanically-induced ATP efflux and for ATP-induced ATP release through ..
  11. doi Ischemic preconditioning requires opening of pannexin-1/P2X(7) channels not only during preconditioning but again after index ischemia at full reperfusion
    Donald A Vessey
    Department of Veterans Affairs Medical Center, Liver Study Unit 151 K, 4150 Clement St, San Francisco, CA 94121, USA
    Mol Cell Biochem 351:77-84. 2011
    ..This correlates with an inability to generate phospho-Akt at reperfusion. IPC prevents this loss and thereby primes the cell for response to cardioprotectants released at full reperfusion...
  12. doi Functional significance of the negative-feedback regulation of ATP release via pannexin-1 hemichannels under ischemic stress in astrocytes
    Sadahiro Iwabuchi
    Laboratory of Cellular Cybernetics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo 060 0814, Japan
    Neurochem Int 58:376-84. 2011
    The opening of pannexin-1 (Px1) hemichannels is regulated by the activity of P2X(7) receptors (P2X(7)Rs)...
  13. doi Regulation of the pannexin-1 promoter in the rat epididymis
    Julie Dufresne
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada
    Biol Reprod 91:143. 2014
    ..b>PANX1 and PANX3 are expressed in the male rat reproductive tract and their levels are regulated by androgens in the ..
  14. doi Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation
    Steven J Celetti
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    J Cell Sci 123:1363-72. 2010
    ..In this study, Panx1 and Panx3 were detected in the epidermis of 13.5 day embryonic mice...
  15. pmc Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage
    Abraham Cisneros-Mejorado
    Achucarro Basque Center for Neuroscience, Departamento de Neurociencias and CIBERNED, Universidad del Pais Vasco UPV EHU, Leioa, Spain
    J Cereb Blood Flow Metab 35:843-50. 2015
    ..reduced with P2X7 and pannexin-1 blockers as well as in organotypic cultures derived from mice lacking P2X7 and pannexin 1. Subsequently, we used transient middle cerebral artery occlusion to monitor the neuroprotective effect of those ..
  16. pmc Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder
    Jonathan M Beckel
    Department of Anaesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, 19104, USA
    J Physiol 593:1857-71. 2015
    ..v. administration did not. Intravesical instillation of small interfering RNA-containing liposomes decreased pannexin 1 expression in the rat urothelium in vivo and increased bladder capacity...
  17. doi Pannexin-1 channels do not regulate α1-adrenoceptor-mediated vasoconstriction in resistance arteries
    James A Angus
    Cardiovascular Therapeutics Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia Electronic address
    Eur J Pharmacol 750:43-51. 2015
    ..that in small resistance arteries α1D-adrenoceptor-mediated contraction is intimately linked to pannexin-1 (Px1) hemichannels that open to allow the release of ATP, from the smooth muscle effector cell, that acts back on P2Y ..
  18. doi The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials
    Stefanie Bunse
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University, Bochum, Germany
    FEBS J 276:6258-70. 2009
    b>Pannexin 1 (Panx1), a member of the second gap junction protein family identified in vertebrates, appears to preferentially form non-junctional membrane channels...
  19. doi Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 322:1555-9. 2008
    Pannexin-1 (Px1) is expressed at postsynaptic sites in pyramidal neurons, suggesting that these hemichannels contribute to dendritic signals associated with synaptic function...
  20. pmc Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development
    Yuhao Zhang
    From the Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine and
    J Biol Chem 290:14647-55. 2015
    Pannexin-1 (Panx1) is a large-pore membrane channel involved in the release of ATP and other signaling mediators...
  21. pmc Trafficking dynamics of glycosylated pannexin 1 proteins
    Daniela Boassa
    National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego, La Jolla, California 92093 0608, USA
    Cell Commun Adhes 15:119-32. 2008
    ..Rat pannexin 1 is glycosylated at N254 and this residue is important for plasma membrane targeting...
  22. doi Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity
    Nicholas L Weilinger
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Neurosci 19:432-42. 2016
    ..NMDARs, Src kinase and Panx1 form a signaling complex, and activation of Panx1 required phosphorylation at Y308...
  23. pmc Pannexin protein expression in the rat middle cerebral artery
    Alan R Burns
    College of Optometry, University of Houston, Houston, Tex, USA
    J Vasc Res 49:101-10. 2012
    ..Pannexins are a recently discovered family of proteins that could potentially be involved in cell-to-cell communication. Herein, we sought to determine whether pannexins are expressed in rat middle cerebral artery (MCA)...
  24. doi Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases
    Nicholas L Weilinger
    Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 32:12579-88. 2012
    ..Pannexin-1 (Panx1) channels can be activated both by ischemia and NMDA receptors (NMDARs), but the mechanisms of Panx1 activation ..
  25. pmc Pannexin1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated free fatty acids in liver cells
    Feng Xiao
    Deptartment of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9151, USA
    Am J Physiol Cell Physiol 303:C1034-44. 2012
    ..Recent studies have shown that apoptosis in nonhepatic cells stimulates ATP release via activation of pannexin1 (panx1), and extracellular ATP functions as a proinflammatory signal for recruitment and activation of the inflammatory ..
  26. pmc Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain
    Ruchi Gehi
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 286:27639-53. 2011
    Pannexin1 (Panx1) is an integral membrane protein comprised of three species as follows: an unglycosylated core-Gly0, a high mannose-Gly1, and a complex glycosylated Gly2 species...
  27. pmc Pannexins, a family of gap junction proteins expressed in brain
    Roberto Bruzzone
    Department of Clinical Neurobiology, Interdisciplinary Center for Neurosciences, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:13644-9. 2003
    ..Here, we show that two of these genes, pannexin 1 (Px1) and Px2, are abundantly expressed in the CNS...
  28. pmc Expression and roles of pannexins in ATP release in the pituitary gland
    Shuo Li
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892 4510, USA
    Endocrinology 152:2342-52. 2011
    ..b>Pannexin 1 was more abundantly expressed in the anterior lobe, whereas pannexin 2 was more abundantly expressed in the ..
  29. doi Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat
    Patrick Turmel
    INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada
    Mol Reprod Dev 78:124-38. 2011
    ..To evaluate the role of Panxs in the male reproductive tract, we investigated the distribution and regulation of Panx1 and 3 in the testis, efferent ducts (ED), and epididymis of adult rats...
  30. pmc Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other
    Cinzia Ambrosi
    National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, California 92093 0608, USA
    J Biol Chem 285:24420-31. 2010
    ..Protein gel and Western blot analysis confirmed Pannexin1 (Panx1) or Pannexin2 (Panx2) as the channel-forming proteins...
  31. pmc Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors, and KATP channels
    Masahito Kawamura
    Department of Pharmacology, Jikei University School of Medicine, Minato ku, Tokyo 105 8461, Japan
    J Neurosci 30:3886-95. 2010
    ....
  32. doi Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    J Cardiovasc Pharmacol Ther 15:190-5. 2010
    ..Inhibitors of other P2X receptors, P2Y receptors, or connexins did not affect IPC. We conclude that a pannexin-1/P2X(7) channel is responsible for the release of cardioprotectants induced by ischemic pre- and postconditioning...
  33. pmc Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions
    Ruchi Bhalla-Gehi
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 285:9147-60. 2010
    ..In this study, we utilized Cx43-positive BICR-M1R(k) cells to stably express Panx1, Panx3, or Panx1-green fluorescent protein (GFP) to assess their trafficking, cell surface dynamics, and interplay ..
  34. pmc Identification and characterization of pannexin expression in the mammalian cochlea
    Xiao Hui Wang
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Comp Neurol 512:336-46. 2009
    ..To date, three pannexin isoforms (Panx1, 2, and 3) have been cloned from mouse and human genomes...
  35. ncbi Expression of pannexin family of proteins in the retina
    Galina Dvoriantchikova
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    FEBS Lett 580:2178-82. 2006
    Expression of the Panx1 and Panx2 members of the pannexin family of gap junction proteins was studied in the retina by in situ hybridization and qRT-PCR...