Pdpn

Summary

Gene Symbol: Pdpn
Description: podoplanin
Alias: E11, Gp38, OTS-8, RTI40, T1-alpha, podoplanin, E11 antigen epitope, RTI140, T1A, epithelial cell surface transmembrane protein antigen, glycoprotein 38, pulmonary type I alveolar epithelial cell transmembrane differentiation marker, type I cell 40 kDa protein
Species: rat

Top Publications

  1. pmc Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model
    Ichiro Hirahara
    Department of Nephrology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Biomed Res Int 2015:289751. 2015
  2. pmc Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Am J Pathol 166:913-21. 2005
  3. doi Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model
    Genshiro Esumi
    Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Pediatr Surg Int 27:187-92. 2011
  4. pmc Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
    Klaas Koop
    Department of Pathology, Leiden University Medical Center, Building 1, L1 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 173:315-26. 2008
  5. doi Intratumoral lymphatics and lymphatic invasion are associated with tumor aggressiveness and poor prognosis in renal cell carcinoma
    Akio Horiguchi
    Department of Urology, National Defense Medical College, Tokorozawa City, Saitama, Japan
    Urology 71:928-32. 2008
  6. doi Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich-Wistar-Frömter rats
    D H T Ijpelaar
    Leiden Univ Medical Center, Dept of Pathology Bldg 1, L1Q, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Physiol Renal Physiol 294:F758-67. 2008
  7. doi Detection of lymphovascular invasion in early breast cancer by D2-40 (podoplanin): a clinically useful predictor for axillary lymph node metastases
    Michael Braun
    Department of Obstetrics and Gynecology, University of Bonn, Bonn, Germany
    Breast Cancer Res Treat 112:503-11. 2008
  8. ncbi Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms
    Hongbo Yu
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 128:767-75. 2007
  9. ncbi Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain
    Yukinari Kato
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Biochem Biophys Res Commun 349:1301-7. 2006
  10. ncbi Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours
    Si Brask Sonne
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 449:200-6. 2006

Scientific Experts

  • Klaas Koop
  • James A Frank
  • Joseph A Kitterman
  • J N Vanderbilt
  • Yukinari Kato
  • D H T Ijpelaar
  • Genshiro Esumi
  • Michael Braun
  • Vivien Schacht
  • Ichiro Hirahara
  • Akio Horiguchi
  • Hongbo Yu
  • Kimberly L Dumoff
  • Si Brask Sonne
  • Kazuhiko Mishima
  • Gareth R Clegg
  • Young Kwon Hong
  • Michael Detmar
  • Telugu A Narasaraju
  • Katsuyuki Matsui
  • Shigeaki Muto
  • Toshimi Imai
  • Yoshiyuki Morishita
  • Eiji Kusano
  • Daisuke Nagata
  • Hideki Sato
  • Akira Onishi
  • Makoto Sumitomo
  • A Wetterwald
  • Tomohiko Asano
  • L G Dobbs
  • Fumihiro Kimura
  • Keiichi Ito
  • Masamichi Hayakawa
  • M C Williams
  • Jason L Hornick
  • Geraldine S Pinkus
  • Youya Nakazawa
  • Alexander Marks
  • Henrik Leffers
  • Mika K Kaneko
  • David Holtz
  • Eleanor E Harris
  • Akiko Kunita
  • Naoya Fujita
  • Takanori Hirose
  • Kristian Almstrup
  • Geza Acs
  • Niels E Skakkebaek
  • Takashi Tsuruo
  • Ewa Rajpert-De Meyts
  • Amy S Herlihy
  • R F Gonzalez
  • John E Nielsen
  • Ryo Nishikawa
  • A K Rishi
  • Paul J Zhang
  • Masao Matsutani
  • Christina E Hoei-Hansen
  • Xiaowei Xu
  • Christina S Chu
  • Christine Tyrrell
  • Mary C McElroy
  • Michael F Beers
  • Louise A Johnson
  • Soheil S Dadras
  • David G Jackson
  • Stuart R McKechnie
  • David Harrison
  • S Breiteneder-Geleff
  • Harold F Dvorak
  • Dontscho Kerjaschki
  • Zhongming Chen
  • Maria I Ramirez
  • Silvana Geleff
  • Dian Feng
  • Deming Gou
  • Natasha Harvey
  • Richard J Johnson
  • Ann M Dvorak
  • Lin Liu
  • Sigurd Krieger
  • Guillermo Oliver
  • Nili Jin
  • Duk Hee Kang
  • Pirjo Laakkonen
  • Satoshi Hirakawa
  • Mary Williams
  • Karl Mechtler
  • Chintagari R Narendranath

Detail Information

Publications26

  1. pmc Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model
    Ichiro Hirahara
    Department of Nephrology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Biomed Res Int 2015:289751. 2015
    ..In rats treated with MGO, peritoneal fibrous thickening with the appearance of basophilic spindle cells with podoplanin, cytokeratin, and α-smooth muscle actin at the surface of the peritoneum was observed...
  2. pmc Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Am J Pathol 166:913-21. 2005
    The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and ..
  3. doi Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model
    Genshiro Esumi
    Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Pediatr Surg Int 27:187-92. 2011
    ..The aim of this study was to investigate the effect of IGF-1 and IGF-2 on tissue cultures of fetal hypoplastic lungs obtained from nitrofen-induced CDH model rats...
  4. pmc Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
    Klaas Koop
    Department of Pathology, Leiden University Medical Center, Building 1, L1 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 173:315-26. 2008
    ..expression and distribution of the podocyte proteins was similar between the two strains, except for the protein podoplanin. At 4 weeks, podoplanin began decreasing in the glomeruli of Dahl SS rats in a focal and segmental fashion...
  5. doi Intratumoral lymphatics and lymphatic invasion are associated with tumor aggressiveness and poor prognosis in renal cell carcinoma
    Akio Horiguchi
    Department of Urology, National Defense Medical College, Tokorozawa City, Saitama, Japan
    Urology 71:928-32. 2008
    ..Because lymphangiogenesis and lymphatic invasion are key steps to nodal involvement in various types of cancer, we examined the clinicopathologic significance of lymphangiogenesis and lymphatic invasion in renal cell carcinoma...
  6. doi Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich-Wistar-Frömter rats
    D H T Ijpelaar
    Leiden Univ Medical Center, Dept of Pathology Bldg 1, L1Q, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Physiol Renal Physiol 294:F758-67. 2008
    ..Albuminuria developed starting at 6 wk of age and coincided with focal and segmental loss of podoplanin, increased expression of desmin, entrapment of albumin in affected podocytes, and focal and segmental foot ..
  7. doi Detection of lymphovascular invasion in early breast cancer by D2-40 (podoplanin): a clinically useful predictor for axillary lymph node metastases
    Michael Braun
    Department of Obstetrics and Gynecology, University of Bonn, Bonn, Germany
    Breast Cancer Res Treat 112:503-11. 2008
    ..LVI is associated with axillary lymph node metastases (ALNM) and a long-term prognostic factor. A precise identification of LVI would have a strong clinical impact for breast cancer patients...
  8. ncbi Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms
    Hongbo Yu
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 128:767-75. 2007
    b>Podoplanin has been shown to be expressed in primary germ cell tumors (GCTs), with conflicting results regarding its specificity...
  9. ncbi Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain
    Yukinari Kato
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Biochem Biophys Res Commun 349:1301-7. 2006
    The mucin-type sialoglycoprotein, podoplanin (aggrus), is a platelet-aggregating factor on cancer cells. We previously described up-regulated expression of podoplanin in malignant astrocytic tumors including glioblastoma...
  10. ncbi Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours
    Si Brask Sonne
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 449:200-6. 2006
    ..PDPN encodes podoplanin (Aggrus, human gp36, T1A-2), a transmembrane glycoprotein expressed in lymphatic endothelium and various solid ..
  11. ncbi Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma
    Kazuhiko Mishima
    Department of Neurosurgery, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, 350 0495, Saitama, Japan
    Acta Neuropathol 111:563-8. 2006
    b>Podoplanin, a mucin-like transmembrane sialoglycoprotein, promotes platelet aggregation and may be involved in cancer cell migration, invasion, metastasis, and malignant progression...
  12. ncbi Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation
    Kimberly L Dumoff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Mod Pathol 19:708-16. 2006
    ..We have recently found that low podoplanin immunoreactivity in cervix carcinoma correlated with the presence of lymphatic invasion and nodal metastasis...
  13. ncbi Coexpression of RTI40 with alveolar epithelial type II cell proteins in lungs following injury: identification of alveolar intermediate cell types
    Gareth R Clegg
    Edinburgh Medical Research Council Centre for Inflammation Research, University of Edinburgh, Scotland, UK
    Am J Physiol Lung Cell Mol Physiol 289:L382-90. 2005
    ..These data also suggest that the coexpression of RTI(40) with ATII cell proteins may be used to identify and investigate ATII cell transdifferentiation to ATI cells following injury...
  14. ncbi Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives
    A K Rishi
    Pulmonary Center, Boston University School of Medicine, Massachusetts 02118
    Dev Biol 167:294-306. 1995
    We report here the identification and characterization of a novel gene, T1 alpha, expressed in high abundance in adult rat lung, fetal lung, and early fetal brain...
  15. ncbi Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors
    Yukinari Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 278:51599-605. 2003
    ..These results suggest that Aggrus/T1alpha is a newly identified, platelet aggregation-inducing factor expressed in colorectal tumors...
  16. ncbi Protein nitration in rat lungs during hyperoxia exposure: a possible role of myeloperoxidase
    Telugu A Narasaraju
    Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1037-45. 2003
    ..These studies suggest that protein nitration during hyperoxia may be mediated in part by MPO generated from activated phagocytic cells, and such protein modifications may contribute to hyperoxia-mediated lung injury...
  17. ncbi Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels
    Katsuyuki Matsui
    Institute of Clinical Pathology, University of Vienna, Allgemeines Krankenhaus, Vienna, Austria
    J Am Soc Nephrol 14:1981-9. 2003
    ..e., the membrane mucoprotein podoplanin with specificity for lymphatic endothelia, and the glycosyl-phosphatidylinositol (GPI)-anchored membrane enzyme ..
  18. pmc T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 22:3546-56. 2003
    Within the vascular system, the mucin-type transmembrane glycoprotein T1alpha/podoplanin is predominantly expressed by lymphatic endothelium, and recent studies have shown that it is regulated by the lymphatic-specific homeobox gene Prox1...
  19. ncbi Effects of oligohydramnios on lung growth and maturation in the fetal rat
    Joseph A Kitterman
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, California 94143, USA
    Am J Physiol Lung Cell Mol Physiol 282:L431-9. 2002
    ..01). We conclude that OH, which retards lung growth, has little effect on surfactant and impedes formation of type I cells relative to type II cells...
  20. ncbi Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs
    James A Frank
    Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, San Francisco, California 94143 0130, USA
    Am J Respir Crit Care Med 165:242-9. 2002
    ..Plasma RTI40, a marker of type I epithelial cell injury, decreased 46% when tidal volume was reduced from 12 to 6 ml/kg and ..
  21. ncbi Purification and analysis of RTI40, a type I alveolar epithelial cell apical membrane protein
    R F Gonzalez
    Cardiovascular Research Institute, University of California, San Francisco 94143, USA
    Biochim Biophys Acta 1429:208-16. 1998
    b>RTI40 is a 40-42 kDa protein that, within the lung, is specific to the apical plasma membrane of the rat alveolar type I cell. Type I cells cover greater than 95% of the internal surface area of the lung...
  22. ncbi Characterization of the gene and promoter for RTI40, a differentiation marker of type I alveolar epithelial cells
    J N Vanderbilt
    Cardiovascular Research Institute, and Departments of Medicine and Pediatrics, University of California San Francisco, California, USA
    Am J Respir Cell Mol Biol 19:662-71. 1998
    ..the differentiated state of the alveolar epithelium, we have analyzed the gene for rat type I cell 40 kD protein (RTI40), an apical integral plasma membrane protein expressed in type I but not type II alveolar epithelial cells...
  23. pmc Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis
    S Breiteneder-Geleff
    Department of Clinical Pathology, University of Vienna, Austria
    Am J Pathol 151:1141-52. 1997
    ..To indicate that this protein could be associated with transformation of arborized foot processes to flat feet (Latin, pes planus) we have called it podoplanin.
  24. ncbi Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes
    A Wetterwald
    Department of Pathophysiology, University of Berne, Switzerland
    Bone 18:125-32. 1996
    ..8 cells, using a eukaryotic expression system. The E11 cDNA sequence revealed homology with the murine OTS-8/gp38 sequence...
  25. ncbi T1 alpha protein is developmentally regulated and expressed by alveolar type I cells, choroid plexus, and ciliary epithelia of adult rats
    M C Williams
    Department of Medicine, Boston University School of Medicine, Massachusetts, USA
    Am J Respir Cell Mol Biol 14:577-85. 1996
    b>T1 alpha is the first marker gene known to be expressed in the adult lung solely by the alveolar type I epithelial cell...
  26. ncbi A type I cell-specific protein is a biochemical marker of epithelial injury in a rat model of pneumonia
    M C McElroy
    Department of Anesthesia, University of California, San Francisco 94143
    Am J Physiol 268:L181-6. 1995
    In this study we determined whether the alveolar fluid content of a specific epithelial type I cell protein, rTI40, can be used as a biochemical marker for lung injury...