Ppara

Summary

Gene Symbol: Ppara
Description: peroxisome proliferator activated receptor alpha
Alias: PPAR, peroxisome proliferator-activated receptor alpha, PPAR-alpha, nuclear receptor subfamily 1 group C member 1
Species: rat

Top Publications

  1. doi Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle, Germany
    Biochim Biophys Acta 1780:899-904. 2008
  2. ncbi Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle
    Melissa A Stavinoha
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 W Holcombe Blvd, IBT 1011B, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 287:E888-95. 2004
  3. doi Effects of ovariectomy on PPAR alpha, SREBP-1c, and SCD-1 gene expression in the rat liver
    Amélie Paquette
    Département de Kinésiologie, Universite de Montreal, Montreal, Quebec, Canada
    Menopause 15:1169-75. 2008
  4. ncbi Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals
    Iwona Zak
    Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
    Clin Chim Acta 362:110-8. 2005
  5. ncbi Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor
    Adam J Belanger
    Genzyme Corporation, 49 New York Avenue, Framingham, MA 01701, USA
    Biochem Biophys Res Commun 364:567-72. 2007
  6. pmc Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
    M Gottlicher
    Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Proc Natl Acad Sci U S A 89:4653-7. 1992
  7. ncbi Molecular scanning of the human PPARa gene: association of the L162v mutation with hyperapobetalipoproteinemia
    M C Vohl
    Montreal Genome Centre, McGill University Health Centre, Montreal, Canada
    J Lipid Res 41:945-52. 2000
  8. ncbi Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism
    Andries J Gilde
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Circ Res 92:518-24. 2003
  9. ncbi Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats
    Nicholas D Oakes
    AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Am J Physiol Regul Integr Comp Physiol 289:R938-46. 2005
  10. ncbi Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation
    Kim Ravnskjaer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    J Mol Endocrinol 36:289-99. 2006

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. doi Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle, Germany
    Biochim Biophys Acta 1780:899-904. 2008
    Peroxisome proliferator-activated receptor (PPAR)-alpha mediates an adaptive response to fasting by up-regulation of genes involved in fatty acid oxidation and ketone body synthesis...
  2. ncbi Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle
    Melissa A Stavinoha
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 W Holcombe Blvd, IBT 1011B, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 287:E888-95. 2004
    ..We previously showed that ucp3 is a peroxisome proliferator-activated receptor-alpha (PPAR alpha)-regulated gene, allowing induction when FA availability increases...
  3. doi Effects of ovariectomy on PPAR alpha, SREBP-1c, and SCD-1 gene expression in the rat liver
    Amélie Paquette
    Département de Kinésiologie, Universite de Montreal, Montreal, Quebec, Canada
    Menopause 15:1169-75. 2008
    To investigate whether estrogen deficiency modifies the expression of important genes involved in hepatic lipid regulation, PPAR alpha, SREBP-1c, and SCD-1, in association with fat accumulation in the liver of ovariectomized rats.
  4. ncbi Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals
    Iwona Zak
    Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
    Clin Chim Acta 362:110-8. 2005
    ..The aim of our study was to assess the polymorphic variants frequencies of ICAM1, APOE, PPARA and PAI-1 genes in CAD patients and healthy blood donors and to find specific arrangement of polymorphic variants ..
  5. ncbi Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor
    Adam J Belanger
    Genzyme Corporation, 49 New York Avenue, Framingham, MA 01701, USA
    Biochem Biophys Res Commun 364:567-72. 2007
    ..These results suggest that HIF-1 may be involved in hypoxia-induced suppression of fatty acid metabolism in cardiomyocytes by reducing the DNA binding activity of PPARalpha/RXR...
  6. pmc Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
    M Gottlicher
    Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Proc Natl Acad Sci U S A 89:4653-7. 1992
    Peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643 have been shown to activate PPAR (peroxisome proliferator-activated receptor), a member of the steroid nuclear receptor superfamily...
  7. ncbi Molecular scanning of the human PPARa gene: association of the L162v mutation with hyperapobetalipoproteinemia
    M C Vohl
    Montreal Genome Centre, McGill University Health Centre, Montreal, Canada
    J Lipid Res 41:945-52. 2000
    ..02). These results suggest an association between the PPARalpha V162 allele and the atherogenic/hyperapolipoprotein B dyslipidemia...
  8. ncbi Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism
    Andries J Gilde
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Circ Res 92:518-24. 2003
    ..To explore the involvement of each of the PPAR isoforms, neonatal rat cardiomyocytes were exposed to FA or to ligands specific for either PPARalpha (Wy-14,643), ..
  9. ncbi Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats
    Nicholas D Oakes
    AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Am J Physiol Regul Integr Comp Physiol 289:R938-46. 2005
    ..The present work demonstrates that tesaglitazar ameliorates these abnormalities and enhances insulin sensitivity in this animal model...
  10. ncbi Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation
    Kim Ravnskjaer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    J Mol Endocrinol 36:289-99. 2006
    ..The peroxisome proliferator activated receptor alpha (PPARalpha) is a key activator of genes involved in beta-cell fatty acid oxidation, and ..
  11. ncbi Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate
    Ying Sun
    Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China
    Endocrinology 149:662-71. 2008
    ..Our findings have potential clinical implications for the use of PPARalpha agonists in the treatment of type 2 diabetes...
  12. pmc Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:365-74. 2009
    ..We determined here whether peroxisome proliferator-activated receptor (PPAR) activators accelerate postnatal SC acidification...
  13. doi PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway
    Aliaksandr A Bulhak
    Division of Cardiology, Department of Medicine, The Rolf Luft Center for Diabetes Research, Karolinska University Hospital, Solna, S 171 76 Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 296:H719-27. 2009
    ..The ligands of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) reduce ischemia-reperfusion injury in nondiabetic animals...
  14. ncbi PPAR alpha stimulates the rat gastrin-producing cell
    Ingunn Bakke
    Department of Intra abdominal Diseases, Norwegian University of Science and Technology NTNU, NO 7489, Trondheim, Norway
    Mol Cell Endocrinol 195:89-97. 2002
    ..Ciprofibrate is a specific ligand for the nuclear peroxisome proliferator-activated receptor alpha (PPAR alpha)...
  15. ncbi Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells
    Orsolya Mezei
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Nutr 133:1238-43. 2003
    ..Peroxisome-proliferator activated receptors (PPAR) are promiscuous nuclear receptors that regulate the transcription of genes involved in lipid and glucose ..
  16. ncbi Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac deve
    Michael Steinmetz
    Department of Pediatric Cardiology and Intensive Care Medicine, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Basic Res Cardiol 100:263-9. 2005
    ..The aim of this study was to investigate the changes in mRNA expression levels of genes involved in the control of cardiac fatty acid metabolism in the transition from neonatal to adult life...
  17. pmc ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells
    Michael Boergesen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark
    J Biol Chem 286:13214-25. 2011
    ..The transcription factor peroxisome proliferator-activated receptor α (PPARα) is an important regulator of genes involved in fatty acid metabolism and has been shown to protect against lipid-..
  18. pmc Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin
    Emma S Garratt
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 8:e67483. 2013
    ..Both human and mouse peroxisome proliferator activated receptor (PPAR) α genes have multiple promoters, although their function is unknown...
  19. pmc PPARα activation induces N(ε)-Lys-acetylation of rat liver peroxisomal multifunctional enzyme type 1
    Miguel A Contreras
    Department of Pediatrics, The Darby Children s Research Institute, Medical University of South Carolina, Charleston, SC, 29425, USA
    Lipids 49:119-31. 2014
    ..Organelle protein samples isolated by density gradient centrifugation from PPARα-agonist treated rat liver screened with an anti-N(ε)-acetyl lysine antibody revealed a single protein band of 75 ..
  20. doi PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats
    Yan Zhang
    Department of Pharmacology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, PR China Department of Gynecology and Obstetrics, Wuxi Maternal and Child Health Hospital, the Affiliated Hospital of Nanjing Medical University, Wuxi 214002, Jiangsu Province, PR China
    Cytokine 75:127-35. 2015
    Peroxisome proliferator-activated receptor (PPAR) α/γ may control lipid metabolism and inflammatory response by regulating the downstream target genes, and play a crucial role in the process of non-alcoholic steatohepatitis (NASH) ..
  21. ncbi Modulation of PPAR in aging, inflammation, and calorie restriction
    Bokyung Sung
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Korea
    J Gerontol A Biol Sci Med Sci 59:997-1006. 2004
    ..Based on these findings, we conclude that the altered expression of PPARs may be due to increased oxidative stress with age, and that CR prevents these decreases through its antioxidative action...
  22. ncbi Differential expression of stress response genes in the H-Tx rat model of congenital hydrocephalus
    Frances W Morgan
    Wade s Center for Hydrocephalus, Health Research Institute, Orlando Regional Healthcare System, Inc, Orlando, FL 32806, USA
    Brain Res Mol Brain Res 138:273-90. 2005
    ..07) and peroxisome proliferator-activated receptor-alpha (PPAR-alpha, 0.04). Five (3.73%) of the 134 detected transcripts were elevated and 20 (17...
  23. ncbi Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise
    Katja Kannisto
    Department of Medicine, Karolinska Instituet, Stockholm, Sweden
    Int J Mol Med 17:45-52. 2006
    ..Little is known about PPAR activation in vivo and the existence of overlapping functions between PPARalpha, -delta and -gamma...
  24. ncbi Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats
    Nuria Roglans
    Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, University of Barcelona and IBUB Institute of Biomedicine University of Barcelona, Barcelona, Spain
    Hepatology 45:778-88. 2007
    ....
  25. pmc Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
    Daniel A Enquobahrie
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:1683-8. 2008
    ..cholesterol ester transfer protein (CETP), interleukin-8 (IL8), peroxisome proliferator activator receptor-alpha (PPARA), and Toll-like receptor 4 (TLR4) genes with incident nonfatal myocardial infarction (MI) or ischemic stroke...
  26. doi Differential transcriptional expression of PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages and T-cell subsets of non-obese diabetic mice
    Nik Soriani Yaacob
    School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia
    J Clin Immunol 29:595-602. 2009
    ....
  27. doi Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-α
    Marco Koch
    Dr Senckenbergische Anatomie, Institut für Anatomie II, Goethe Universitat, Frankfurt am Main, Germany
    Neurotox Res 19:330-40. 2011
    ..Here we show that PEA (0.001-1 μM) and the synthetic peroxisome proliferator-activated receptor (PPAR)-alpha agonist 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (Wy-14,643; 0...
  28. pmc Peroxisome proliferator-activated receptors-alpha modulate dopamine cell activity through nicotinic receptors
    Miriam Melis
    B B Brodie Department of Neuroscience, University of Cagliari, Monserrato, Italy
    Biol Psychiatry 68:256-64. 2010
    ..Among these, endogenous ligands to the nuclear receptor-transcription factor peroxisome proliferator-activated receptors type-alpha (PPARalpha) have been recently found to suppress nicotine-induced responses of dopamine neurons...
  29. doi [Expression of FXR mRNA, PPAR alpha mRNA and bile acid metabolism related genes in intrahepatic cholestasis of pregnant rats]
    Qing yun Shi
    Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Beijing 100038, China
    Zhonghua Gan Zang Bing Za Zhi 18:927-30. 2010
    To study the expressions of FXR, PPARa and Bile acid metabolism related genes in intrahepatic cholestasis of pregnant rats.
  30. doi Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α
    G Mattace Raso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Neuroendocrinol 23:591-600. 2011
    ..In the present study, we report that PEA, acting as a ligand of peroxisome-proliferator activated receptor (PPAR)-α, might regulate neurosteroidogenesis in astrocytes, which, similar to other glial cells and neurones, have the ..
  31. doi Exercise improved rat metabolism by raising PPAR-α
    S Zhang
    Fudan University, Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai, China
    Int J Sports Med 32:568-73. 2011
    ..the aim of this study was to determine whether the expression of peroxisome proliferator-activated receptor (PPAR)-α, γ and adiponectin receptor 2 in OLETF rat liver were altered in conjunction with improved metabolism with ..
  32. pmc Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis
    Yutaka Hatano
    Department of Dermatology, Faculty of Medicine, Oita University, Yufu Shi, Oita, Japan
    J Invest Dermatol 131:1845-52. 2011
    ..In contrast, topical applications of ligands of peroxisome proliferator-activated receptor-α (PPARα) not only reduce inflammation but also improve cutaneous barrier homeostasis...
  33. pmc PPARα activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4
    Kang Le
    Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Arch Biochem Biophys 518:71-8. 2012
    Peroxisome proliferator-activated receptor alpha (PPARα) has been implicated in the pathogenesis of cardiac hypertrophy, although its mechanism of action remains largely unknown...
  34. doi Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes
    Fabrizio Damiano
    Laboratory of Biochemistry and Molecular Biology, Department of Biological and Environmental Science and Technologies, University of Salento, via prov le Lecce Monteroni, Lecce 73100, Italy
    Int J Biochem Cell Biol 44:659-68. 2012
    ..we provide evidences demonstrating that CiC expression is regulated by peroxisome proliferator-activated receptor (PPAR) alpha and gamma in hepatocytes and adipocytes, respectively...
  35. ncbi Physiological role of peroxisome proliferator-activated receptors type α on dopamine systems
    Miriam Melis
    Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato CA, Italy
    CNS Neurol Disord Drug Targets 12:70-7. 2013
    ..PEA), acting as endogenous ligands of alpha-type peroxisome proliferator-activated receptors (PPARα), block nicotine-induced excitation of dopamine neurons revealed their role as important endogenous negative ..
  36. doi Spinal cord injury induced changes of nuclear receptors PPARα and LXRβ and modulation with oleic acid/albumin treatment
    Daniel Fandel
    Laboratorio Regeneración Nerviosa, Hospital Nacional de Paraplejicos, Servicio de Salud de Castilla La Mancha, Toledo, Spain
    Brain Res 1535:89-105. 2013
    ..models of spinal cord injury (SCI) pharmacological activation of peroxisome proliferator activated receptors (PPAR) and liver X receptors (LXR) were used to reduce tissue damage and promote behavioral recovery in animal models...
  37. ncbi Reactivity of the immune system and activities of PPARα and PPARγ in the liver under conditions of LPS-induced acute inflammatory response in hypertensive ISIAH rats
    A V Shurligina
    Institute of Physiology, Siberian Branch of Russian Academy of Medical Sciences Institute of Clinical and Experimental Lymphology, Siberian Division of Russian Academy of Medical Sciences Institute of Therapy, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
    Bull Exp Biol Med 155:421-4. 2013
    The effects of LPS from E. coli on DNA-binding activities of PPARα and PPARγ in the liver and immune system parameters of were studied in hypertensive ISIAH rats and normotensive WAG rats...
  38. pmc Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice
    Min Hi Park
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea Laboratory of Biochemistry, Pusan National University, Busan, Korea
    PLoS ONE 8:e78815. 2013
    Peroxisome proliferator-activated receptor (PPAR) α/γ dual agonists have been developed to alleviate metabolic disorders and have the potential to be used as therapeutic agents for the treatment of type 2 diabetes...
  39. doi Protective effect of peroxisome proliferator activator receptor (PPAR)-α and -γ ligands against methotrexate-induced nephrotoxicity
    Mohamed A Ibrahim
    Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt
    Immunopharmacol Immunotoxicol 36:130-7. 2014
    ..The anticancer drug methotrexate (MTX) may cause multi-organ toxicities, including nephrotoxicity...
  40. pmc Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion
    Frits Mattijssen
    From the Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Biol Chem 289:19279-93. 2014
    ..Oral dosing with Wy14643 similarly induced Hilpda mRNA levels in livers of wild-type mice but not Ppara(-/-) mice...
  41. doi Involvement of hepatic peroxisome proliferator-activated receptor α/γ in the therapeutic effect of osthole on high-fat and high-sucrose-induced steatohepatitis in rats
    Xi Zhao
    Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, China Department of Pharmaceutical Laboratory, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu Province, China
    Int Immunopharmacol 22:176-81. 2014
    ..Our previous studies have indicated that osthole may be a dual agonist of peroxisome proliferator-activated receptor (PPAR) α/γ and decrease the hepatic lipid accumulation...
  42. doi Overproduction of altered VLDL in an insulin-resistance rat model: Influence of SREBP-1c and PPAR-α
    Diego Lucero
    Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, Buenos Aires, Argentina Electronic address
    Clin Investig Arterioscler 27:167-74. 2015
    ..of sterol regulatory element binding protein 1c (SREBP-1c) and of peroxisome proliferator-activated receptor-α (PPAR-α), with the features of composition and size of VLDL in an insulin-resistance rat model induced by a sucrose rich ..
  43. doi Ursolic acid prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPARα
    Yanan Zhang
    Department of Anesthesiology, Jining First People s Hospital, Jining, Shandong 272011, P R China
    Mol Med Rep 13:5309-16. 2016
    ..Evidence suggests that obesity causes the downregulation of peroxisome proliferator‑activated receptor (PPAR)α in the spinal cord, contributing to augmented peripheral edema and inflammatory hyperalgesia...
  44. ncbi Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV
    Hongmei Qiu
    a Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P R China
    Pharm Biol 55:227-232. 2017
    ..Berberine has been demonstrated to possess extensive medicine activity, yet relatively little is known about its effect on VSMCs proliferation. Many studies showed that PPARα and NO participated in the process of VSMCs proliferation.
  45. ncbi Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity
    Wasana K Sumanasekera
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 42:10726-35. 2003
    ..Thus, we describe the chaperone complex as being a regulator of PPARalpha and PPARbeta activity and have identified a novel, subtype-specific, inhibitory role for Hsp90...
  46. pmc Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors
    Paola Mascia
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Medications Discovery Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 69:633-41. 2011
    ..OEA) and palmitoylethanolamide, which are ligands for alpha-type peroxisome proliferator-activated nuclear receptors (PPAR-α). Here, we evaluated whether directly acting PPAR-α agonists can modulate reward-related effects of nicotine.
  47. doi Effects of soy protein on alcoholic liver disease in rats undergoing ethanol withdrawal
    Hsin Yi Yang
    Department of Medical Nutrition, I Shou University, Kaohsiung 824, Taiwan
    J Nutr Biochem 23:679-84. 2012
    ..This investigation attempted to clarify the effects of soy protein on alcoholic liver disease (ALD) in rats undergoing ethanol withdrawal...
  48. pmc Peroxisome proliferator-activated receptor-γ regulates inflammation and renin-angiotensin system activity in the hypothalamic paraventricular nucleus and ameliorates peripheral manifestations of heart failure
    Yang Yu
    Department of Internal Medicine, Veterans Affairs Medical Center, Iowa City, IA, USA
    Hypertension 59:477-84. 2012
    Activation of peroxisome proliferator-activated receptor (PPAR)-γ, a nuclear transcription factor, has been shown to inhibit the production of proinflammatory cytokines and, in peripheral tissues, to downregulate the renin-angiotensin ..
  49. doi Treatment with pharmacological PPARα agonists stimulates the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents
    Robert Ringseis
    Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University, Giessen, Germany
    Biochim Biophys Acta 1830:2105-17. 2013
    Treatment of hyperlipidemic patients with fibrates, agonists of peroxisome proliferator-activated receptor α (PPARα), provokes muscle atrophy as a side effect. The molecular mechanism underlying this phenomenon is still unknown...
  50. pmc Effect of NDP-α-MSH on PPAR-γ and -β expression and anti-inflammatory cytokine release in rat astrocytes and microglia
    Lila Carniglia
    Instituto de Investigaciones Biomedicas, School of Medicine, University of Buenos Aires CONICET, Buenos Aires, Argentina
    PLoS ONE 8:e57313. 2013
    ..of inflammation, we investigated the effect of an α-MSH analog, [Nle(4), D-Phe(7)]-α-MSH (NDP-α-MSH), on PPAR-β and PPAR-γ gene and protein expression in rat primary astrocytes and microglia...
  51. ncbi The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin
    A Shalev
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Endocrinology 137:4499-502. 1996
    ..The observations that PPAR alpha is a regulator of hepatic lipid metabolism and that the insulin-sensitizing thiazolidinediones are ligands for ..
  52. ncbi A regulatory role for RIP140 in nuclear receptor activation
    E Treuter
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Mol Endocrinol 12:864-81. 1998
    ..Using peroxisome proliferator-activated receptor-alpha (PPAR alpha) as bait in a yeast two-hybrid screening, we have isolated nuclear factor RIP140 whose function in receptor ..
  53. ncbi Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48
    Daniel Lindén
    Department of Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
    J Biol Chem 277:23044-53. 2002
    ..The PPAR alpha agonist induced a significant increase in the accumulation of pulse-labeled apoB-100 even after a short pulse (2-..
  54. pmc Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism
    Mark J Holness
    Department of Diabetes and Metabolic Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Medical Sciences Building, Queen Mary, University of London, London E1 4NS, UK
    Biochem J 364:687-94. 2002
    ....
  55. ncbi Peroxisome proliferator-activated receptor agonists inhibit inflammatory edema and hyperalgesia
    Bradley K Taylor
    Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 64108, USA
    Inflammation 26:121-7. 2002
    ..We conclude that systemic administration of potent PPARalpha and PPARgamma agonists exert anti-hyperalgesic and/or antiinflammatory actions in vivo, possibly by interfering with the initiation of inflammation...
  56. pmc Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator
    Sailesh Surapureddi
    Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 99:11836-41. 2002
    Peroxisome proliferator-activated receptor alpha (PPAR alpha) plays a central role in the cell-specific pleiotropic responses induced by structurally diverse synthetic chemicals designated as peroxisome proliferators...
  57. ncbi Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha
    Christine Chao
    University of Missouri Kansas City, 2411 Holmes Street, M3 115, Kansas City, MO 64108 2792, USA
    Mech Ageing Dev 123:1469-76. 2002
    ..to hepatocarcinogenicity produced by agonists of peroxisome proliferator-activated receptor alpha (PPAR alpha). Mechanisms involved in these effects are not well understood...
  58. ncbi 17beta-estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle
    S E Campbell
    Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Mol Endocrinol 31:37-45. 2003
    ..05) by E(2) treatment, although protein content remained unaltered. These data demonstrate the novel regulation of E(2) on PPARalpha and genes encoding key proteins that are pivotal in regulating skeletal muscle lipid oxidative flux...
  59. ncbi Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease
    S Brune
    Department of Psychiatry, University of Bonn, Germany
    J Neural Transm (Vienna) 110:1041-50. 2003
    The peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a member of the steroid hormone super family of ligand-inducible transcription factors, involved in glucose and lipid metabolism...
  60. ncbi PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats
    Quy N Diep
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Que, Canada H2W 1R7
    J Mol Cell Cardiol 36:295-304. 2004
    Peroxisome proliferator-activated receptor (PPAR)alpha is highly expressed in the heart. PPAR alpha may play a role in cardiac hypertrophy, but effects on cardiac function, inflammation, and fibrosis are unknown...
  61. ncbi Expression of peroxisome proliferator-activated receptor isoform proteins in the rat kidney
    Kazunori Sato
    Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 27:417-25. 2004
    ..Among the 3 isoforms, PPAR- alpha is involved in lipid metabolism in the liver, while PPAR-gamma(-gamma1 and -gamma2) is involved in adipocyte ..
  62. ncbi Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
    Tamie Nakajima
    Department of Hygiene and Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 40:972-80. 2004
    ..Humans may be more susceptible to liver toxicity induced by ethanol as PPARalpha expression in human liver is considerably lower compared to that of rodents...
  63. ncbi Down regulation of hepatic PPARalpha function by AhR ligand
    Zein Shaban
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
    J Vet Med Sci 66:1377-86. 2004
    ..b>Peroxisome proliferator activated receptor alpha (PPARalpha) is a nuclear receptor involved in the maintenance of lipid and glucose ..
  64. ncbi Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection
    Sebastien Dharancy
    Equipe Mixte INSERM 0114, Centre Hospitalier Universitaire, Lille, France
    Gastroenterology 128:334-42. 2005
    ....
  65. ncbi Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade
    Jan Michael Williams
    Department of Physiology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 46:366-71. 2005
    ..Clofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, increases protein expression of cytochrome P450 4A (CYP4A), which is responsible for 20-HETE ..
  66. ncbi PPAR-alpha expression inversely correlates with inflammatory cytokines IL-1beta and TNF-alpha in aging rats
    David S Gelinas
    Centre for Research in Neurodegenerative Diseases and Department of Laboratory Medicine and Pathobiology, University of Toronto, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario, M5S3H2, Canada
    Neurochem Res 30:1369-75. 2005
    ..Cultured cell studies showed that DHEAS may mediate its action by counteracting aging-associated inflammation via PPAR-alpha activation...
  67. ncbi Absence of peroxisome proliferators-activated receptors (PPAR)alpha enhanced the multiple organ failure induced by zymosan
    Rosanna Di Paola
    Dipartimento Clinico Sperimentale di Medicina e Farmacologia, Facolta di Medicina e Chirurgia, Universita di Messina, Via C Valeria, Gazzi, 98100 Messina, Italy
    Shock 26:477-84. 2006
    The peroxisome proliferator-activated receptor (PPAR) alpha is a member of the nuclear receptor superfamily of ligand-dependent transcription factors related to retinoid, steroid, and thyroid hormone receptors...
  68. ncbi PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy
    Mark J Holness
    Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Am J Physiol Endocrinol Metab 292:E1087-94. 2007
    ....
  69. ncbi Relationship between lipoprotein lipase and peroxisome proliferator-activated receptor-alpha expression in rat liver during development
    M Panadero
    Facultad de Farmacia, Universidad San Pablo CEU, E 28668 Boadilla del Monte, Madrid, Spain
    J Physiol Biochem 62:189-98. 2006
    ..study was addressed to determine whether the high expression of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in rat liver during the perinatal stage plays a role in the induction of liver lipoprotein lipase (LPL) ..
  70. ncbi Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD
    A H Remels
    Department of Respiratory Medicine, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 30:245-52. 2007
    ..Recent evidence suggests involvement of the peroxisome proliferator-activated receptors (PPARs) and PPAR-gamma coactivator (PGC)-1alpha in regulation of skeletal muscle morphology and metabolism, and mitochondrial ..
  71. ncbi Activation of peroxisome proliferator-activated receptor-alpha prevents glycogen synthase 3beta phosphorylation and inhibits cardiac hypertrophy
    Ruifang Li
    Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, PR China
    FEBS Lett 581:3311-6. 2007
    Activation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) has been recently reported to inhibit vascular inflammatory response and prevent cardiac hypertrophy...
  72. ncbi Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury
    Xiao Ru Chen
    Laboratoire de Pharmacologie de la Circulation Cérébrale, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    J Neurotrauma 24:1119-31. 2007
    ..Our data suggest that PPARalpha activation could mediate pleiotropic effects and strengthen that it could be a promising therapeutic strategy for TBI...
  73. ncbi Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 56:175-83. 2007
    ..Furthermore, the present results also indicate that an increased carnitine biosynthesis also contributes to the clofibrate-induced increase in hepatic carnitine concentration...
  74. pmc WY14,643, a PPARalpha ligand, attenuates expression of anti-glomerular basement membrane disease
    D C Archer
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA, USA
    Clin Exp Immunol 150:386-96. 2007
    ..These studies suggest that PPARalpha ligands may be a novel treatment for inflammatory renal disease...
  75. ncbi Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity
    Karine Hellemans
    Diabetes Research Center DRC, Brussels Free University VUB, Belgium
    FEBS J 274:6094-105. 2007
    ..These observations indicate that PPARalpha and RXR regulate beta-cell susceptibility to long-chain fatty acid toxicity by increasing the rates of beta-oxidation and by involving peroxisomes in fatty acid metabolism...
  76. pmc Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures
    Manjeet K Paintlia
    Department of Pediatrics, Medical University of South Carolina and Ralph H Johnson VA Medical Center, Charleston, South Carolina 29425, USA
    J Neurochem 105:956-70. 2008
    ..Both NAC and WY14643, a peroxisome proliferator-activated receptor (PPAR)-alpha agonist attenuated these LCM-induced effects in OL-progenitors...
  77. doi Effects of IL-15 on rat brown adipose tissue: uncoupling proteins and PPARs
    Vanessa Almendro
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
    Obesity (Silver Spring) 16:285-9. 2008
    ..The aim of this study was to investigate the effects of IL-15 on brown adipose tissue (BAT), and in particular on genes related to lipid metabolism in this tissue...
  78. doi Suppression of cardiac myocyte hypertrophy by conjugated linoleic acid: role of peroxisome proliferator-activated receptors alpha and gamma
    Caroline P Alibin
    Faculty of Pharmacy, University of Manitoba and the Canadian Centre for Agri Food Research in Health and Medicine, St Boniface General Hospital Research Centre, Winnipeg, Manitoba R2H 2A6, Canada
    J Biol Chem 283:10707-15. 2008
    ..CLA stimulated PPAR activity in cardiomyocytes, and the anti-hypertrophic effects of CLA were blocked by genetic and pharmacological ..
  79. doi Involvement of ZIP/p62 in the regulation of PPARalpha transcriptional activity by p38-MAPK
    Claire Diradourian
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique, UMR 8104, 24 rue du Faubourg Saint Jacques, Paris, France
    Biochim Biophys Acta 1781:239-44. 2008
    ..In conclusion, we showed that p38 activation induced PPARalpha phosphorylation and inhibition of its transcriptional activity through a trimeric interaction between p38-MAPK, ZIP/p62 and PPARalpha...
  80. doi Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury
    Xiao Ru Chen
    Equipe de recherche Pharmacologie de la Circulation Cérébrale EA 2510, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
    J Pharmacol Exp Ther 326:966-74. 2008
    We and others have demonstrated that fibrates [peroxisome proliferator-activated receptor (PPAR)alpha agonists] and statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) exerted neuroprotective and pleiotropic effects in ..
  81. doi Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy
    Ling Jing
    Department of Cardiology, First Clinical College of Harbin Medical University, Harbin, Heilongjiang, China
    Alcohol Clin Exp Res 32:1999-2007. 2008
    ....
  82. doi The peroxisome proliferator activator receptor alpha/delta agonists linoleic acid and bezafibrate upregulate osteoblast differentiation and induce periosteal bone formation in vivo
    Karen Still
    Academic Unit of Child Health, University of Sheffield Sheffield Children s Hospital, Sheffield, S10 2TH, UK
    Calcif Tissue Int 83:285-92. 2008
    ..The aims of this study were to determine the effects of PPARalpha/delta agonists on bone in vitro and in vivo. PPAR agonists were examined in vitro using the fibroblastic colony-forming unit (CFU-f) assay...
  83. pmc Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity
    Jessica M Sapiro
    Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA
    J Lipid Res 50:1621-9. 2009
    ..Enhancing TAG hydrolysis through ADRP knockdown or ATGL overexpression increased PPARalpha activity. These results indicate that TAG hydrolysis and the consequential release of fatty acids regulate PPARalpha activity...
  84. pmc Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice
    Sunhyo Jeong
    Department of Life Sciences, Mokwon University, Daejeon 302 729, Korea
    Exp Mol Med 41:397-405. 2009
    ..These results suggest that fenofibrate-induced fatty acid beta-oxidation in visceral adipose tissue may be one of the major factors leading to decreased adipocyte size and improved insulin sensitivity...
  85. doi Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells
    María Martínez de Ubago
    Department of Medical Biochemistry and Molecular Biology, Virgen Macarena University Hospital, Seville, Spain
    Biochim Biophys Acta 1791:740-5. 2009
    ..OEA is a PPAR-alpha agonist, and recently it has been found that OEA is an endogenous ligand of an orphan receptor...
  86. doi Differential effects of chronic, in vivo, PPAR's stimulation on the myocardial subcellular redistribution of FAT/CD36 and FABPpm
    Agnieszka Kalinowska
    Department of Physiology, Medical University of Białystok, Białystok, Poland
    FEBS Lett 583:2527-34. 2009
    ..Observed effects of chronic PPAR stimulation were not related to either AMPK or ERK1/2 activation.
  87. doi Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-alpha signaling pathway
    Rong Sen Meng
    Department of Cardiology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, PR China
    Eur J Pharmacol 620:63-70. 2009
    ..Luciferase activity assay suggested that AICAR elevates PPARalpha transcriptional activity. These results indicate that AMPK plays an important role in the inhibition of cardiac hypertrophy by activating the PPARalpha signaling pathway...
  88. ncbi Skeletal muscle characteristics of rats with obesity, diabetes, hypertension, and hyperlipidemia
    Fumiko Nagatomo
    Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Japan
    J Atheroscler Thromb 16:576-85. 2009
    ..We investigated mRNA expression levels and fiber profiles in the skeletal muscles of rats with obesity, diabetes, hypertension, and/or hyperlipidemia...
  89. doi Dietary naringenin increases hepatic peroxisome proliferators-activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats
    Kae Won Cho
    Department of Nutrition, University of Massachusetts, Amherst, MA 10003, USA
    Eur J Nutr 50:81-8. 2011
    ..However, the lipid-lowering potential of naringenin at the concentrations in the dietary range and its underlying mechanisms have yet to be fully elucidated...
  90. pmc AMPK enhances the expression of pancreatic duodenal homeobox-1 via PPARalpha, but not PPARgamma, in rat insulinoma cell line INS-1
    Hua Guo
    Central Laboratory, Provincial Hospital affiliated to Shandong University, Ji Nan, China
    Acta Pharmacol Sin 31:963-9. 2010
    ....
  91. doi PPARα contributes to colonic protection in mice with DSS-induced colitis
    Yasu Taka Azuma
    Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Izumisano, Osaka 598 8531, Japan
    Int Immunopharmacol 10:1261-7. 2010
    ..complementary model of colonic inflammation to examine the roles of peroxisome proliferator-activated receptor α (PPARα) in colonic inflammation and thus its possible role in IBD...
  92. doi Peroxisome proliferator-activated receptor {alpha} agonism prevents renal damage and the oxidative stress and inflammatory processes affecting the brains of stroke-prone rats
    Paolo Gelosa
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Pharmacol Exp Ther 335:324-31. 2010
    ..The aim of this study was to examine the effects of peroxisome proliferator-activated receptor (PPAR) agonists on the tissue damage affecting salt-loaded spontaneously hypertensive stroke-prone rats ( SHRSPs), an ..
  93. doi Effect of phase delay lighting rotation schedule on daily expression of per2, bmal1, rev-erbα, pparα, and pdk4 genes in the heart and liver of Wistar rats
    Kristína Szántóová
    Department of Animal Physiology and Ethology, Comenius University Bratislava, Bratislava, Slovak Republic
    Mol Cell Biochem 348:53-60. 2011
    ..Nuclear receptor PPARα is supposed to be a functional interface between circadian clock and metabolism, and its interconnection with rev-..
  94. ncbi [Statin reduced triglyceride level via activating peroxisome proliferator activated receptor α and upregulating apolipoprotein A5 in hypertriglyceridemic rats]
    Xian sheng Huang
    Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Xin Xue Guan Bing Za Zhi 38:809-13. 2010
    ..to explore the potential role of apolipoprotein A5 (apoA5) on the hypertriglyceridemia (HTG)-lowering effects of statin...
  95. pmc WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis
    Enrico Briguglio
    Istituto Policattedra di Odontostomatologia, Universita degli Studi di Messina, 98100 Messina, Italy
    PPAR Res 2010:193019. 2010
    We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis...
  96. pmc Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress
    Seong Ho Yoo
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Toxicol Lett 202:23-9. 2011
    ..Using age-matched Ppara-null and wild-type (WT) mice, we demonstrate that the deletion of PPARα aggravates LPS-mediated liver injury ..
  97. doi Effect of preischemic treatment with fenofibrate, a peroxisome proliferator-activated receptor-α ligand, on hepatic ischemia-reperfusion injury in rats
    Vivian Boshra
    Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    J Mol Histol 42:113-22. 2011
    ..Preischemic treatment with fenofibrate at a dose of 50 mg/kg significantly attenuated the biochemical and structural alterations of I/R-induced liver injury...
  98. pmc Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha)
    Ana Fernández-Alvarez
    Instituto de Biomedicina de Valencia, IBV CSIC, Jaime Roig 11, 46010 Valencia, Spain
    J Biol Chem 286:21466-77. 2011
    ..We discovered that peroxisome proliferation-activated receptor alpha (PPARα) agonists enhance the activity of the SREBP1c promoter; a DR1 element, at -453 in the human promoter was involved ..
  99. pmc Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsis
    Stephen W Standage
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Shock 37:164-9. 2012
    The peroxisome proliferator-activated receptor α (PPAR-α) is a member of the nuclear receptor family with many important physiologic roles related to metabolism and inflammation...
  100. ncbi Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha
    R Chu
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 271:27670-6. 1996
    ..Protein(s) interacting with PPAR isoforms (alpha, delta, and gamma) may modulate the PPAR-mediated transcriptional activation...
  101. ncbi Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension
    Yalda Jamshidi
    Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK
    Circulation 105:950-5. 2002
    ....