Ppargc1a

Summary

Gene Symbol: Ppargc1a
Description: PPARG coactivator 1 alpha
Alias: Ppargc1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1-alpha, PGC-1alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, peroxisome proliferative activated receptor gamma coactivator 1, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Species: rat

Top Publications

  1. ncbi Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism
    Andries J Gilde
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Circ Res 92:518-24. 2003
  2. pmc PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice
    Mei Tran
    Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Invest 121:4003-14. 2011
  3. ncbi Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha)
    Yi Zhang
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 279:53963-71. 2004
  4. pmc Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue
    Lindsey N Sutherland
    Alberta Diabetes Institute, University of Alberta, Edmonton, Canada
    J Physiol 587:1607-17. 2009
  5. pmc Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice
    Heiko Bugger
    Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 58:1986-97. 2009
  6. pmc Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain
    Obinna I Ndubuizu
    Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue BRB 501A, Cleveland, OH 44106 4930, USA
    Brain Res 1366:101-9. 2010
  7. ncbi SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
    Shino Nemoto
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 280:16456-60. 2005
  8. pmc Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha)
    Ramy R Attia
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 285:2375-85. 2010
  9. doi Activation of calcium/calmodulin-dependent protein kinase IV and peroxisome proliferator-activated receptor γ coactivator-1α signaling pathway protects against neuronal injury and promotes mitochondrial biogenesis in the hippocampal CA1 subfield after tra
    Shang Der Chen
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Neurosci Res 88:3144-54. 2010
  10. pmc Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training
    Frederic Derbré
    Laboratory Movement Sport and Health Sciences, University Rennes, France
    Age (Dordr) 34:669-79. 2012

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. ncbi Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism
    Andries J Gilde
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Circ Res 92:518-24. 2003
    ....
  2. pmc PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice
    Mei Tran
    Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Invest 121:4003-14. 2011
    ....
  3. ncbi Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha)
    Yi Zhang
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 279:53963-71. 2004
    ..Our data demonstrate that PGC-1 alpha participates in the stimulation of CPT-I alpha gene expression by thyroid hormone and suggest that PGC-1 alpha is a coactivator for thyroid hormone...
  4. pmc Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue
    Lindsey N Sutherland
    Alberta Diabetes Institute, University of Alberta, Edmonton, Canada
    J Physiol 587:1607-17. 2009
    ..Furthermore it would appear that increases in circulating catecholamine levels may be one potential mechanism mediating exercise induced increases in PGC-1alpha mRNA expression in rat abdominal adipose tissue...
  5. pmc Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice
    Heiko Bugger
    Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 58:1986-97. 2009
    ..To elucidate the molecular basis for mitochondrial dysfunction, which has been implicated in the pathogenesis of diabetes complications...
  6. pmc Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain
    Obinna I Ndubuizu
    Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue BRB 501A, Cleveland, OH 44106 4930, USA
    Brain Res 1366:101-9. 2010
    ..Overall, our results suggest a compensatory HIF-1-independent preservation of hypoxic-induced microvascular angiogenesis in the aged rat brain...
  7. ncbi SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
    Shino Nemoto
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 280:16456-60. 2005
    ..These results provide a direct link between the sirtuins, a family of proteins linked to lifespan determination and PGC-1alpha, a coactivator that regulates cellular metabolism...
  8. pmc Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha)
    Ramy R Attia
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 285:2375-85. 2010
    ..Our results indicate that T(3) regulates PGC-1 alpha abundance and association with hepatic genes, and in turn PGC-1 alpha is an important participant in the T(3) induction of selected genes...
  9. doi Activation of calcium/calmodulin-dependent protein kinase IV and peroxisome proliferator-activated receptor γ coactivator-1α signaling pathway protects against neuronal injury and promotes mitochondrial biogenesis in the hippocampal CA1 subfield after tra
    Shang Der Chen
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Neurosci Res 88:3144-54. 2010
    ..This study provides correlative evidence for the neuroprotective cascade of CaMKIV/PGC-1α which implicates at least in part the mitochondrial antioxidants UCP2 and SOD2 as well as mitochondrial biogenesis in ischemic brain injury...
  10. pmc Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training
    Frederic Derbré
    Laboratory Movement Sport and Health Sciences, University Rennes, France
    Age (Dordr) 34:669-79. 2012
    ....
  11. pmc Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist
    Marcin Buler
    Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, POB 5000 Aapistie 5B, 90014 Oulu, Finland
    J Biol Chem 287:1847-60. 2012
    ..Induction of IL1Rn by PGC-1α and AMPK may be involved in the beneficial effects of exercise and caloric restriction and putative anti-inflammatory effects of metformin...
  12. pmc Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function
    C Ciron
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Hum Mol Genet 21:1861-76. 2012
    ..These results highlight the central role of PGC-1α in the function and survival of dopaminergic neurons and the critical need for maintaining physiological levels of PGC-1α activity...
  13. pmc Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone
    Shalini Thakran
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 288:807-18. 2013
    ..Our results indicate that SIRT1 contributes to the T(3) regulation of hepatic genes...
  14. pmc PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy
    Shiqin Xiong
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:2474-87. 2010
    ..We provide novel mechanistic insights by which Ang II may mediate its ROS-dependent pathophysiologic effects on multiple cardiometabolic diseases...
  15. doi PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1
    Takashi Yazawa
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Shimoaizuki 23 3, Matsuoka, Eiheiji cho, Fukui 910 1193, Japan
    Mol Endocrinol 24:485-96. 2010
    ..These results indicate that PGC-1alpha is involved in progesterone production in ovarian granulosa cells by potentiating transcriptional activities of the NR5A family proteins...
  16. doi PGC-1 alpha accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes
    Min Chen
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China
    Biochem Biophys Res Commun 396:894-900. 2010
    ..Unraveling the PGC-1 alpha-calcium handling pathway sheds new light on the role of PGC-1 alpha in the therapy of cardiac diseases...
  17. ncbi PGC-1α and FOXO1 mRNA levels and fiber characteristics of the soleus and plantaris muscles in rats after hindlimb unloading
    Fumiko Nagatomo
    Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Histol Histopathol 26:1545-53. 2011
    ..We conclude that decreased oxidative capacity and fiber atrophy in unloaded skeletal muscles are associated with decreased PGC-1α and increased FOXO1 mRNA levels...
  18. doi High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα-FoxO3a-PGC-1α pathway
    Hyun Wha Chung
    Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Nephrol Dial Transplant 27:2213-25. 2012
    ..We evaluated whether PPARα-FoxOs-PGC-1α signaling in overfed spontaneously hypertensive rats (SHR) has a protective role in the kidney...
  19. doi Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes
    Yanfang Chen
    Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Mol Cell Endocrinol 362:11-8. 2012
    ..We conclude that RIP140 and PGC-1α exert antagonistic role in regulating cardiac energy state and mitochondrial biogenesis...
  20. doi ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats
    Ghorbangol Ashabi
    Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Behav Brain Res 232:165-73. 2012
    ..Surprisingly, these factors were returned to vehicle level, 20 days after Aβ-injection. Our findings reinforce the potential neuroprotective effect of these inhibitors against the Aβ toxicity...
  21. doi Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor-γ coactivators PGC-1α/PGC-1β-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver
    Vito Pesce
    Department of Biochemistry and Molecular Biology E Quagliariello, University of Bari, Bari, Italy
    Rejuvenation Res 15:136-9. 2012
    ..Furthermore, a remarkable decline of Drp1 and of Mfn2 proteins is reported here for the first time, suggesting a reduced mitochondrial dynamics in aging liver with no effect of ALCAR treatment...
  22. pmc Diammonium glycyrrhizinate upregulates PGC-1α and protects against Aβ1-42-induced neurotoxicity
    Xiaolei Zhu
    Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, People s Republic of China
    PLoS ONE 7:e35823. 2012
    ....
  23. pmc Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice
    Li Na Zhang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    Diabetes 62:1297-307. 2013
    ..Our results demonstrated that a novel small molecule selectively elevated the expression of PGC-1α in myotubes and skeletal muscle and exerted promising therapeutic effects for treating type 2 diabetes...
  24. pmc Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses
    Francesc X Soriano
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    Antioxid Redox Signal 14:1425-36. 2011
    ..Thus, PGC-1α and SMRT are antagonistic regulators of neuronal vulnerability to oxidative stress. Further, this coactivator-corepressor antagonism is regulated by the activity status of the cell, with implications for neuronal viability...
  25. ncbi cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats
    M Goto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
    Biochem Biophys Res Commun 274:350-4. 2000
    ..These results demonstrate that expression of the PGC-1 gene in Epi muscle is induced not only by cold exposure but also by prolonged low-intensity physical exercise...
  26. ncbi Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression
    T Kakuma
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Endocrinology 141:4576-82. 2000
    ..We conclude that leptin action is required for normal basal and cold-stimulated PGC-1 expression in BAT in rodents and that hyperleptinemia rapidly up-regulates its expression, at least in part, by direct action...
  27. ncbi Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells
    Anna Planavila
    Unidad de Farmacologia, Departamento de Farmacologia y Quimica Terapeutica, Facultad de Farmacia, Universidad de Barcelona, Spain
    Biochim Biophys Acta 1736:120-7. 2005
    ....
  28. pmc Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms
    Prabodh Sadana
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Mol Cell Endocrinol 267:6-16. 2007
    ..Overall, our results demonstrate that PGC-1beta is a coactivator in the T3 induction of CPT-Ialpha and that PGC-1beta has similarities and differences with the PGC-1alpha isoform...
  29. ncbi The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)
    Jean Francois Louet
    Institut Cochin, Departement d Endocrinologie, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 277:37991-8000. 2002
    ..In addition to the key role that PGC-1 plays in glucose homeostasis, it may also be critical for lipid homeostasis. Taken together these observations suggest that PGC-1 acts to coordinate the process of metabolic adaptation in the liver...
  30. ncbi Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle
    Shin Terada
    Laboratory of Exercise Physiology, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku City, Tokyo, Japan
    Biochem Biophys Res Commun 296:350-4. 2002
    ..These results may suggest that an acute bout of low-intensity prolonged swimming exercise directly enhances the PGC-1 mRNA expression in the activated muscle during exercise, possibly through, at least in part, an AMPK-related mechanism...
  31. ncbi A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Diabetes 52:895-8. 2003
    ..These data indicate that the Gly482Ser missense polymorphism in PGC-1 has metabolic consequences on lipid metabolism that could influence insulin secretion...
  32. ncbi PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations
    Isabella Irrcher
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 284:C1669-77. 2003
    ....
  33. ncbi Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
    Laurie K Russell
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 94:525-33. 2004
    ....
  34. ncbi Free fatty acids increase PGC-1alpha expression in isolated rat islets
    Peixiang Zhang
    Institute of Mecular Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu 210093, PR China
    FEBS Lett 579:1446-52. 2005
    ..These data suggest that hyperlipidemia and hyperglycemia regulate PGC-1alpha expression in islets differently, and elevated PGC-1alpha by FFA plays an important role in chronic hyperlipidemia-induced beta-cell dysfunction...
  35. ncbi LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training
    Apiradee Sriwijitkamol
    Diabetes Division, University of Texas Health Science Center at San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 290:E925-32. 2006
    ..54, P = 0.02), and PGC-1alpha protein content (r = 0.81, P < 0.001). In summary, obese insulin-resistant rodents have abnormalities in the LKB1-AMPK-PGC-1 pathway in muscle, and these abnormalities can be restored by training...
  36. ncbi Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    Libin Cui
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129 USA
    Cell 127:59-69. 2006
    ..These studies suggest a key role for PGC-1alpha in the control of energy metabolism in the early stages of HD pathogenesis...
  37. pmc PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes 57:809-16. 2008
    ..We sought to link peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PPARGC1A), a master transcriptional regulator of mitochondrial oxidative phosphorylation and cellular energy metabolism, ..
  38. pmc Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
    C Ling
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, CRC, 205 02 Malmo, Sweden
    Diabetologia 51:615-22. 2008
    ..coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1alpha; gene PPARGC1A) is a master regulator of mitochondrial genes and its expression is decreased and related to impaired oxidative ..
  39. pmc The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease
    Patrick Weydt
    Department of Neurology, University of Ulm P, W, G, B, L, Ulm, Germany
    Mol Neurodegener 4:3. 2009
    ..for modifier genes of HD age-of-onset had suggested linkage at chromosomal region 4p16-4p15, near the locus of PPARGC1A, the gene coding for PGC-1alpha...
  40. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
    ....
  41. pmc PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons
    Przemyslaw Wareski
    Department of Pharmacology, University of Tartu, Ravila 19, 51014 Tartu, Estonia
    J Biol Chem 284:21379-85. 2009
    ....
  42. pmc Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease
    Hong Van B Che
    Department of Medical Genetics, University of Tuebingen, Calwerstr, 7, 72074 Tuebingen, Germany
    Mol Neurodegener 6:1. 2011
    ..Until now, among others, the gene encoding PCG-1α (PPARGC1A) was shown to modify the AAO in two independent, however small, populations...
  43. pmc PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
    Joo Ho Shin
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 144:689-702. 2011
    ..The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation...
  44. pmc PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease
    Elahe Taherzadeh-Fard
    Department of Human Genetics, Ruhr University Bochum, Germany
    Mol Neurodegener 6:32. 2011
    ..for involvement of PGC-1alpha in HD pathogenesis was generated by the findings that sequence variations in the PPARGC1A gene encoding PGC-1alpha exert modifying effects on the AO in HD...
  45. doi PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model
    Huiyun Liang
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Muscle Nerve 44:947-56. 2011
    ..Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. We sought to determine whether peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) would have a beneficial effect on this disease...
  46. doi Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity
    Emilia Amengual-Cladera
    Grup Metabolisme Energètic i Nutrició, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d Investigacio en Ciencies de la Salut IUNICS, Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
    Metabolism 61:1108-17. 2012
    ..This sexual dimorphism suggests that there are different strategies for retroperitoneal WAT to maintain the energetic and metabolic homeostasis in response to HFD feeding...
  47. doi A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset
    Selma M Soyal
    Department of Laboratory Medicine, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria
    Hum Mol Genet 21:3461-73. 2012
    ..Several single-nucleotide polymorphisms (SNPs) located in two separate haplotype blocks of PPARGC1A have shown associations with Huntington's disease (HD) and Parkinson's disease, but causative SNPs have not been ..
  48. pmc DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways
    John Paul SanGiovanni
    Clinical Trials Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e53155. 2013
    ..We postulated that DNA sequence variation in PPAR gamma (PPARG) co-activator 1 alpha (PPARGC1A), a gene encoding a co-activator of the LCPUFA-sensing PPARG-retinoid X receptor (RXR) transcription complex, may ..
  49. ncbi Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificity
    Hannes Oberkofler
    Department of Laboratory Medicine, Landeskliniken Salzburg, A 5020 Austria
    J Biol Chem 277:16750-7. 2002
    ..These data support a model whereby PPAR subtype specificity is regulated by recruitment of PGC-1...
  50. ncbi Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance
    Robert H Lane
    UCLA School of Medicine, Department of Pediatrics, Mattel Children s Hospital at UCLA, 90095 1752, USA
    Endocrinology 143:2486-90. 2002
    ..These data suggest that increased PGC-1 expression and subsequent hepatic glucose production contribute to the insulin resistance observed in the IUGR juvenile rat...
  51. ncbi Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain
    Rita Marie Cowell
    Department of Psychiatry, University of Alabama, Birmingham, Alabama 35294, USA
    J Comp Neurol 502:1-18. 2007
    ....
  52. pmc PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
    Kathleen A O'Hagan
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 106:2188-93. 2009
    ....
  53. ncbi Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain
    Nicholas A Tritos
    Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    Brain Res 961:255-60. 2003
    ..Hence, PGC-1alpha is widely expressed in the rodent brain, but is not regulated by states of caloric deficiency, leptin, obesity or cold exposure. Its functional role in the brain requires further study...
  54. ncbi Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion
    C T De Souza
    Department of Internal Medicine, State University of Campinas, UNICAMP, Campinas, SP, Brazil
    Diabetologia 46:1522-31. 2003
    ..High adrenergic tonus generated by exposure of homeothermic animals to cold reduces insulin secretion. In this study we evaluate the participation of UCP-2 in cold-induced regulation of insulin secretion...
  55. ncbi Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
    P J Atherton
    School of Life Sciences, University of Dundee, UK
    FASEB J 19:786-8. 2005
    ..We term this behavior the "AMPK-PKB switch." We hypothesize that the AMPK-PKB switch is a mechanism that partially mediates specific adaptations to endurance and resistance training, respectively...
  56. doi NO modulates the molecular basis of rat interscapular brown adipose tissue thermogenesis
    Vesna Petrovic
    University of Belgrade, Institute for Biological Research Sinisa Stankovic, Department of Physiology, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia
    Comp Biochem Physiol C Toxicol Pharmacol 152:147-59. 2010
    ....
  57. pmc Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity
    Scott P Naples
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Appl Physiol Nutr Metab 35:151-62. 2010
    ....
  58. doi AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha and nuclear respiratory factor 1 expression in rat visual cortical neurons
    L Yu
    Department of Pathology, Xi Jing Hospital, 4th Military Medical University, Xi an, Shaanxi 710032, PR China
    Neuroscience 169:23-38. 2010
    ..These results strongly indicate that AMPK is an essential upstream mediator that couples neuronal activity to mitochondrial energy metabolism by regulation of PGC-1alpha-NRF-1 pathway in neurons...
  59. pmc Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease
    Tyisha Hathorn
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Neurobiol Dis 41:43-50. 2011
    ....
  60. pmc Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter
    Elodie Martin
    Laboratoire de Physiopathologie des Maladies du Système Nerveux Central, UMR CNRS 7224 et UMRS INSERM952, Universite Pierre et Marie Curie Paris 6, Paris, France
    Hum Mol Genet 20:2422-34. 2011
    ..Strategies aimed at restoring MSK-1 expression in the striatum might offer a new therapeutic approach to HD...
  61. doi Interactions of the mineralocorticoid receptor--within and without
    Jun Yang
    Department of Medicine, Prince Henry s Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Mol Cell Endocrinol 350:196-205. 2012
    ..This review will discuss the current understanding of interactions involving the MR and highlight their relevance to ligand- or tissue-specificity as well as their suitability as therapeutic targets...
  62. pmc Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H)
    Jagannath Misra
    Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Science and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 286:41972-84. 2011
    ..Overall, for the first time we suggest a novel phenomenon that the curcumin/LKB1/AMPK/SMILE/PGC1α pathway differentially regulates ER stress-mediated gene transcription...
  63. doi The role of PGC-1 and Apoε4 in insomnia
    Chien Chuan Wang
    Department of Psychiatry, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan
    Psychiatr Genet 22:82-7. 2012
    ..The aim of this study was to investigate the role of PGC-1α in insomnia among different mental disorder groups under the control of Apoε4 and other psychosocial factors...
  64. pmc PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity
    Clare Puddifoot
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 32:6995-7000. 2012
    ..The link between mHtt, PGC-1α, and NMDAR activity was also confirmed in rat striatal neurons. Thus, targeting levels of PGC-1α expression may help reduce aberrant NMDAR(EX) activity in disorders where PGC-1α is underexpressed...
  65. pmc p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice
    Christelle Villeneuve
    INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France
    Antioxid Redox Signal 18:5-18. 2013
    ..In the present study, we evaluated the consequences of cardiac MAO-A augmentation on chronic oxidative damage, cardiomyocyte survival, and heart function, and identified the intracellular pathways involved...
  66. pmc Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats
    Laura Paternain
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, C Irunlarrea 1, 31008, Pamplona, Spain
    Dis Model Mech 5:691-7. 2012
    ..in the mRNA levels of leptin (Lep) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (Ppargc1a)...
  67. pmc Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism
    Mi Young Lee
    Department of Internal Medicine, Korea Institute of Lifestyle Medicine Yonsei University Wonju College of Medicine Wonju 220 701, Korea
    Exp Mol Med 44:578-85. 2012
    ..The PPAR-δ agonist may attenuate hepatic fat accumulation through anti-inflammatory mechanism, reducing hepatic PGC-1α gene expression, and improvement of insulin signaling...
  68. pmc Transcutaneous application of carbon dioxide (CO2) induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo
    Yasuo Onishi
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki cho, Kobe, Japan
    PLoS ONE 7:e49189. 2012
    ..These data indicate that transcutaneous application of CO(2) may represent a novel therapeutic tool in the treatment of human MFH...
  69. pmc The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance
    Mingming Gao
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA
    AAPS J 15:258-66. 2013
    ..T0901317 treatment induced reversible aggregation of lipids in the liver. These results suggest that liver X receptor could be a potential target for prevention of obesity and obesity-associated insulin resistance...
  70. doi Training-induced alterations of skeletal muscle mitochondrial biogenesis proteins in non-insulin-dependent type 2 diabetic men
    Nana Chung
    Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany
    Can J Physiol Pharmacol 90:1634-41. 2012
    ..Physical training, as performed in our study, did not reverse the down-regulation of mitochondrial signaling molecules--at least not after 3 months. [corrected]...
  71. doi Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha
    Julie Karsenty
    Aix Marseille Universite, NORT, 13005, Marseille, France
    Eur J Nutr 52:1865-74. 2013
    ..To study, in high-fructose-fed rats, the effect of a dietary enrichment in omega-3 polyunsaturated fatty acids (n-3 PUFA) on the expression of genes involved in lipid metabolism and cardiovascular function...
  72. doi SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats
    Yong Ru Chen
    Intensive Care Unit ICU, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
    Mol Biol Rep 40:3373-80. 2013
    ..PPARγ was elevated in the HFa group, but dropped in the CR and HFr groups. These data suggest that SIRT1 and its regulators are involved in the development of insulin resistance...
  73. pmc AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle
    Brennan K Smith
    Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, N1G 2W1, Canada
    J Physiol 591:1551-61. 2013
    ..These data suggest that exercise causes translocation of PGC-1α preferentially to SS mitochondria in an AMPK-dependent manner...
  74. doi Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training
    G D Wadley
    Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
    Am J Physiol Endocrinol Metab 304:E853-62. 2013
    ..Allopurinol also has little effect on increases in mitochondrial proteins following endurance training...
  75. doi Cyclosporin A attenuates weight gain and improves glucose tolerance in diet-induced obese mice
    Man Jiang
    Model Animal Research Center, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, China
    Mol Cell Endocrinol 370:96-102. 2013
    ..These results suggest that CsA treatment might play beneficial effects against obesity and obesity related hyperglycemia...
  76. doi Roles of histone deacetylation and AMP kinase in regulation of cardiomyocyte PGC-1α gene expression in hypoxia
    Angela Ramjiawan
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Physiol Cell Physiol 304:C1064-72. 2013
    ....
  77. pmc QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats
    Dong Xin Tang
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Integrated Traditional Chinese and Western Medicine, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing 100142, China Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China Department of Oncology, The First Affiliated Hospital of Guiyang College of TCM, Guiyang, Guizhou 550002, China
    Evid Based Complement Alternat Med 2013:480597. 2013
    ....
  78. doi Regulatory role of PGC-1α/PPAR signaling in skeletal muscle metabolic recruitment during cold acclimation
    Ana Stancic
    University of Belgrade, Department of Physiology, Institute for Biological Research Sinisa Stankovic, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia
    J Exp Biol 216:4233-41. 2013
    ..Our results suggest that nitric oxide has a role in maintaining the skeletal muscle oxidative phenotype in late cold acclimation but question its role early in cold acclimation. ..
  79. doi Brain testosterone deficiency leads to down-regulation of mitochondrial gene expression in rat hippocampus accompanied by a decline in peroxisome proliferator-activated receptor-γ coactivator 1α expression
    Takeshi Hioki
    CNS Drug Discovery Unit, Takeda Pharmaceutical Company Limited, 26 1, Muraoka higashi 2, Fujisawa, Kanagawa, 251 8555, Japan
    J Mol Neurosci 52:531-7. 2014
    ..These findings indicate that androgen plays an important role in mitochondrial gene expression in the hippocampus. ..
  80. doi Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
    Luís Rato
    CICS UBI Health Sciences Research Centre, University of Beira Interior, 6201 506 Covilhã, Portugal CNC Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Biochim Biophys Acta 1837:335-44. 2014
    ..This study gives new insights into overall testicular bioenergetics at this prodromal stage of disease. ..
  81. pmc A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort
    Patrick Weydt
    Neurology, Ulm University, 89081 Ulm, Germany
    BMC Neurol 14:1. 2014
    ..The metabolic master regulator PGC-1α, coded by the PPARGC1A gene, coordinates cellular respiration and was shown to play a role in neurodegenerative diseases, including HD.
  82. doi Acetylcholine promotes ROS detoxification against hypoxia/reoxygenation-induced oxidative stress through FoxO3a/PGC-1α dependent superoxide dismutase
    Lei Sun
    Department of Pharmacology, Xi an Jiaotong University Health Science Center, Xi an, Shaanxi, P R China
    Cell Physiol Biochem 34:1614-25. 2014
    ..However, there is little information about its regulation on ROS clearance. Here we investigate the beneficial effects of ACh on superoxide dismutase (SOD) as key ROS-detoxifying enzyme system in cultured rat cardiomyoblasts...
  83. doi BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1α contributes to cardiomyopathy in male rats
    Ying Jiang
    Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Toxicology 329:21-31. 2015
    ..Overall, long-term BPA exposure induces cardiomyopathy in male rats, and the underlying mechanism may involve the impairment of cardiac mitochondrial function and the disturbance of methylation of PGC-1α...
  84. pmc PGC-1α limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species
    Qingbin Zhao
    Department of Geratology, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, Shanxi 710061, China
    Biosci Rep 35:. 2015
    ..Our data support a critical role for PGC-1α in the regulation of proliferation and migration of VSMCs, and provide a useful strategy to protect vessels against atherosclerosis...
  85. pmc Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1α Expression Levels in Rats of Different Age
    Chi Chang Huang
    1 Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan
    Int J Med Sci 13:260-70. 2016
    ..Our result suggests that swimming training can regulate the SIRT1/PGC-1α, AMPK and FOXO3a proteins expression of the soleus muscles in aged rats. ..
  86. pmc Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats
    Soo Jin Yang
    Diabetes Research Institute, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea
    PLoS ONE 6:e17057. 2011
    ..The aim of this study was to address the potential role of Sirt6 in the protective effects of rosiglitazone (RGZ) on hepatic steatosis...
  87. doi Status epilepticus stimulates peroxisome proliferator-activated receptor γ coactivator 1-α/mitochondrial antioxidant system pathway by a nitric oxide-dependent mechanism
    Y X Han
    Department of Neurology, Qilu Hospital, Shandong University, Jinan, China
    Neuroscience 186:128-34. 2011
    ..Furthermore, NO may positively regulate the mitochondrial antioxidant system by inducing PGC-1α in pilocarpine-induced SE...
  88. pmc Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease
    Gaurav Patki
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA
    Neurosci Lett 505:268-72. 2011
    ....
  89. doi Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver
    Shabnam Pooya
    Inserm U954, Medical Faculty and CHU of Nancy, Nancy University, Nancy, France
    J Hepatol 57:344-51. 2012
    ..Methyl donor deficiency produces liver steatosis and predisposes to metabolic syndrome. Whether impaired fatty acid oxidation contributes to this steatosis remains unknown...
  90. doi Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A
    Adriana Laura Burgueño
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires 1427, Argentina
    J Nutr Biochem 24:6-13. 2013
    ..the hypothesis that maternal diet during pregnancy has an impact on fetal metabolic programming through changes in liver mitochondrial DNA (mtDNA) content and transcriptional activity of Ppargc1a and that these effects are sex specific.
  91. doi Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway
    Lei Sun
    Department of Pharmacology, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, P R China
    J Cell Physiol 228:1238-48. 2013
    ....
  92. doi Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system
    Takahiro Yoshizawa
    Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Asahi 3 1 1, Matsumoto, Nagano, 390 8621, Japan
    Hypertension 61:341-51. 2013
    ..These data demonstrate that the AM-RAMP2 system is essential for cardiac metabolism and homeostasis. The AM-RAMP2 system is a promising therapeutic target of heart failure...
  93. pmc Modified high-sucrose diet-induced abdominally obese and normal-weight rats developed high plasma free fatty acid and insulin resistance
    Li Cao
    Division of Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China
    Oxid Med Cell Longev 2012:374346. 2012
    ..Animal models of MONW individuals are lacking. We aimed to develop an abdominally obese and normal-weight (AONW) rat model...
  94. pmc PGC1α plays a critical role in TWEAK-induced cardiac dysfunction
    Jianru Shi
    Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e54054. 2013
    ..The molecular mechanisms underlying TWEAK-induced cardiac pathology, however, remain unknown...
  95. doi Relationship of PGC-1α gene polymorphism with insulin resistance syndrome in Korean children
    Chang Duk Ha
    Sungkyunkwan University, Suwon, Republic of Korea
    Asia Pac J Public Health 27:NP544-51. 2015
    ..The findings of the study suggest that the genetic effects of the PGC-1α genotypes on parameters of insulin resistance might be modulated by lifestyle factors, including PA and body fatness. ..
  96. ncbi The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation
    Coralie Fontaine
    UR545 INSERM, Departement d Atherosclerose, 1, rue Calmette, Institut Pasteur de Lille, 59019 Lille, France
    J Biol Chem 278:37672-80. 2003
    ..These results identify Rev-Erbalpha as a target gene of PPARgamma in adipose tissue and demonstrate a role for this nuclear receptor as a promoter of adipocyte differentiation...
  97. ncbi Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle
    Shin Terada
    Division of Health Promotion and Exercise, National Institute of Health and Nutrition, Shinjuku City, Tokyo 162 8636, Japan
    Am J Physiol Endocrinol Metab 286:E208-16. 2004
    ..The number of factors involved (both AMPK and Ca2+, or Ca2+ only) in exercise-induced PGC-1alpha expression may differ among muscles...
  98. ncbi Peroxisome proliferator-activated receptor gamma coactivator-1alpha, as a transcription amplifier, is not essential for basal and hormone-induced phosphoenolpyruvate carboxykinase gene expression
    Birger Herzog
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 707 Light Hall, Nashville, TN 37232 0615, USA
    Mol Endocrinol 18:807-19. 2004
    ..Taken together, these data suggest that, under chronic fasting conditions, i.e. when high levels of cAMP and glucocorticoids induce PGC-1alpha expression, this coactivator markedly amplifies PEPCK gene expression and gluconeogenesis...
  99. ncbi Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway
    Rachel L G S Oliveira
    Department of Internal Medicine, State University of Campinas, SP 13083 970, Brazil
    Am J Physiol Endocrinol Metab 287:E686-95. 2004
    ....
  100. ncbi Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator
    Ke Ma
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, 38163, USA
    J Biol Chem 280:29525-32. 2005
    ..Our data suggest that by inducing PDK genes PGC-1alpha will direct pyruvate away from metabolism into acetyl-CoA and toward the formation of oxaloacetate and into the gluconeogenic pathway...
  101. ncbi Endurance training increases skeletal muscle LKB1 and PGC-1alpha protein abundance: effects of time and intensity
    Eric B Taylor
    Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 289:E960-8. 2005
    ..The increase in LKB1 and PGC-1alpha with endurance and interval training may function to maintain the training-induced increases in mitochondrial mass...