RAD51

Summary

Gene Symbol: RAD51
Description: recombinase RAD51
Alias: MUT5
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth
    Parisha P Shah
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA
    Mol Cell 39:862-72. 2010
  2. ncbi DNA helicase Srs2 disrupts the Rad51 presynaptic filament
    Lumir Krejci
    Institute of Biotechnology and Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA
    Nature 423:305-9. 2003
  3. pmc Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination
    Rohit Prakash
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 23:67-79. 2009
  4. ncbi Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p
    Efterpi Papouli
    Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, United Kingdom
    Mol Cell 19:123-33. 2005
  5. pmc Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae
    Venkateswarlu Gangavarapu
    University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555 1061, USA
    Mol Cell Biol 27:7758-64. 2007
  6. pmc Deficient SUMO attachment to Flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 microm circle plasmid
    Ling Xiong
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Biol Cell 20:1241-51. 2009
  7. ncbi Further characterization of the yeast pso4-1 mutant: interaction with rad51 and rad52 mutants after photoinduced psoralen lesions
    M A de Morais
    Departamento de Biofisica e Centro de Biotecnologia, UFRGS, Av Bento Goncalves 9500, prédio 2A, B1 4, Campus do Vale, 91501 970 Porto Alegre, RS, Brasil
    Curr Genet 29:211-8. 1996
  8. doi INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination
    Toyoko Tsukuda
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine and Cancer Center, Albuquerque, NM 87131, United States
    DNA Repair (Amst) 8:360-9. 2009
  9. pmc Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells
    Maire K Kelly
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    DNA Repair (Amst) 10:556-66. 2011
  10. pmc Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex
    Catherine E Smith
    Columbia University College of Physicians and Surgeons, Department of Microbiology, New York, NY 10032 2704, USA
    Mol Cell Biol 29:1432-41. 2009

Research Grants

Patents

  1. Human monoclonal antibodies against human cytokines and methods of making and using such antibodies

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. pmc Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth
    Parisha P Shah
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA
    Mol Cell 39:862-72. 2010
    ..Here, we show that Rad51 complexes are dissociated by these translocases in mitotic cells...
  2. ncbi DNA helicase Srs2 disrupts the Rad51 presynaptic filament
    Lumir Krejci
    Institute of Biotechnology and Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA
    Nature 423:305-9. 2003
    ..role of SRS2 in recombination modulation by purifying its encoded product and examining its interactions with the Rad51 recombinase...
  3. pmc Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination
    Rohit Prakash
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 23:67-79. 2009
    ..Importantly, Mph1, but not a helicase-defective variant, dissociates Rad51-made D-loops...
  4. ncbi Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p
    Efterpi Papouli
    Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, United Kingdom
    Mol Cell 19:123-33. 2005
    ..Our findings suggest a mechanism by which SUMO and ubiquitin cooperatively control the choice of pathway for the processing of DNA lesions during replication...
  5. pmc Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae
    Venkateswarlu Gangavarapu
    University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555 1061, USA
    Mol Cell Biol 27:7758-64. 2007
    ..Here, we examine the contributions of the RAD51, RAD52, and RAD54 genes and of the RAD50 and XRS2 genes to the PRR of UV-damaged DNA...
  6. pmc Deficient SUMO attachment to Flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 microm circle plasmid
    Ling Xiong
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Biol Cell 20:1241-51. 2009
    ..This work also illustrates the importance of using cir(o) strains when studying mutants that affect the yeast SUMO pathway, to avoid confusing direct functions of the SUMO pathway with secondary effects of 2 microm amplification...
  7. ncbi Further characterization of the yeast pso4-1 mutant: interaction with rad51 and rad52 mutants after photoinduced psoralen lesions
    M A de Morais
    Departamento de Biofisica e Centro de Biotecnologia, UFRGS, Av Bento Goncalves 9500, prédio 2A, B1 4, Campus do Vale, 91501 970 Porto Alegre, RS, Brasil
    Curr Genet 29:211-8. 1996
    ..The mode of interaction between pso4-1 and rad51 and between pso4-1 and rad52 mutants indicated that the PSO4 gene belongs to the RAD52 epistasis group for strand-..
  8. doi INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination
    Toyoko Tsukuda
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine and Cancer Center, Albuquerque, NM 87131, United States
    DNA Repair (Amst) 8:360-9. 2009
    ..In the absence of homologous donor sequences, RPA recruitment to a DSB appeared normal in arp8Delta, but Rad51 recruitment was defective...
  9. pmc Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells
    Maire K Kelly
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    DNA Repair (Amst) 10:556-66. 2011
    ..We propose that the mechanism of ZRT1-mediated minisatellite instability during quiescence is relevant to human cells, and thus, human disease...
  10. pmc Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex
    Catherine E Smith
    Columbia University College of Physicians and Surgeons, Department of Microbiology, New York, NY 10032 2704, USA
    Mol Cell Biol 29:1432-41. 2009
    ..Thus, the BIR defect observed for rad51 mutants is due to strand invasion failure, whereas the Pol delta complex mutants are proficient for strand ..
  11. pmc Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability
    Kyungjae Myung
    Ludwig Institute for Cancer Research, Cancer Center and Department of Medicine, University of California at San Diego School of Medicine, La Jolla 92093, USA
    Proc Natl Acad Sci U S A 100:6640-5. 2003
    ..These results indicate that coupling of chromatin assembly to DNA replication and DNA repair is critical to maintaining genome stability...
  12. pmc Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis
    S L Gasior
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:8411-8. 2001
    ..Immuno-double-staining experiments in Saccharomyces cerevisiae suggest that Rad51, the eukaryotic recombinase, can assemble at or near sites containing ssb (replication protein A, RPA) during the ..
  13. pmc Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast
    Grzegorz Ira
    Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Cell 115:401-11. 2003
    ..Overexpressing SRS2 nearly eliminates crossovers, whereas overexpression of RAD51 in srs2Delta cells almost completely eliminates the noncrossover recombination pathway...
  14. pmc A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability
    Christine Soustelle
    Commissaritat à l Energy Atomique, UMR 217 CNRS CEA, DSV DRR, Fontenay aux Roses, France
    Mol Cell Biol 24:5130-43. 2004
    ..Genetic interactions between ulp1 and mutations that affect different repair pathways indicated that the RAD51-dependent homologous recombination mechanism, but not excision resynthesis, translesion synthesis, or ..
  15. ncbi Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA
    Peter Chi
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 281:26268-79. 2006
    ..Importantly, Rdh54 physically interacts with the Rad51 recombinase and promotes D-loop formation by the latter...
  16. pmc Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death
    Sandrine Ragu
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 2027, Institut Curie, Batiment 110, Centre Universitaire, 91405 Orsay, France
    Proc Natl Acad Sci U S A 104:9747-52. 2007
    ..growth reduced substantially GCR rates of WT and tsa1 mutants and restored the viability of tsa1 rad6, tsa1 rad51, and tsa1 mre11 double mutants...
  17. pmc Analysis of repair mechanism choice during homologous recombination
    Neta Agmon
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69978, Israel
    Nucleic Acids Res 37:5081-92. 2009
    ..In addition, we show that increasing the distance between two repeated sequences enhances the dependence on Rad51 for colony formation after DSB repair...
  18. ncbi Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
    A Shinohara
    Department of Biology, Faculty of Science, Osaka University, Japan
    Cell 69:457-70. 1992
    The RAD51 gene of S. cerevisiae is involved in mitotic recombination and repair of DNA damage and also in meiosis...
  19. pmc Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins
    S L Hays
    Department of Biochemistry, Stanford University School of Medicine, Stanford University, CA 94305, USA
    Proc Natl Acad Sci U S A 92:6925-9. 1995
    ..Here, we show that the x-ray sensitivity of rad55 and rad57 mutant strains is suppressible by overexpression of RAD51 or RAD52. Virtually complete suppression is provided by the simultaneous overexpression of RAD51 and RAD52...
  20. pmc Functional differences and interactions among the putative RecA homologs Rad51, Rad55, and Rad57
    R D Johnson
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell Biol 15:4843-50. 1995
    ..Three of these genes, RAD51, RAD55, and RAD57, have been identified as putative RecA homologs...
  21. pmc Multiple pathways for homologous recombination in Saccharomyces cerevisiae
    A J Rattray
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genetics 139:45-56. 1995
    ..The majority of recombination events are mediated by a RAD51-dependent pathway, where the RAD54, RAD55 and RAD57 genes function downstream of RAD51...
  22. ncbi Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein
    P Sung
    Sealy Center for Molecular Science, University of Texas Medical Branch at Galveston 77555 1061
    Science 265:1241-3. 1994
    The RAD51 gene of Saccharomyces cerevisiae is required for genetic recombination and DNA double-strand break repair...
  23. pmc Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA
    S L Hays
    Department of Biochemistry, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    Mol Cell Biol 18:4400-6. 1998
    ..Both of the mutant proteins are capable of self-interaction but are unable to interact with Rad51. The mutant proteins also lack the ability to interact with the large subunit of RPA, Rfa1...
  24. ncbi Functional interactions among yeast Rad51 recombinase, Rad52 mediator, and replication protein A in DNA strand exchange
    B Song
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245 3207, USA
    J Biol Chem 275:15895-904. 2000
    b>Rad51-catalyzed DNA strand exchange is greatly enhanced by the single-stranded (ss) DNA binding factor RPA if the latter is introduced after Rad51 has already nucleated onto the initiating ssDNA substrate...
  25. ncbi Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases
    S Gangloff
    CEA de Fontenay aux Roses, UMR 217 CNRS CEA DSV DRR LERA, 92265 Fontenay aux Roses, France
    Nat Genet 25:192-4. 2000
    ..Yeast SRS2 encodes another DNA helicase involved in the maintenance of genome integrity. Our data suggest that some defects observed in BS, WS or RTS are the consequence of unrestrained recombination...
  26. pmc Aberrant double-strand break repair in rad51 mutants of Saccharomyces cerevisiae
    L E Kang
    Department of Microbiology and Institute of Cancer Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell Biol 20:9162-72. 2000
    A number of studies of Saccharomyces cerevisiae have revealed RAD51-independent recombination events...
  27. ncbi Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
    L Wu
    Imperial Cancer Research Fund Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Biol Chem 276:19375-81. 2001
    ..In eukaryotes, a central step in homologous recombination is catalyzed by the RAD51 protein...
  28. ncbi Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae
    K Myung
    Ludwig Institute for Cancer Research, University of California San Diego, 92093, USA
    Nature 411:1073-6. 2001
    ..Mutations that inactivate these pathways cause high rates of GCRs and show synergistic interactions, indicating that the pathways that suppress GCRs all compete for the same DNA substrates...
  29. pmc Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions
    H L Klein
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Genetics 159:1501-9. 2001
    ..The mec1 checkpoint function mutant, defective in the yeast ATR homolog, results in increased recombination through a process that is distinct from that operative in wild-type cells...
  30. ncbi Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein
    Lumir Krejci
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 279:23193-9. 2004
    ..ss) DNA-dependent ATPase activity, a DNA helicase activity, and an ability to disassemble the Rad51-ssDNA nucleoprotein filament, which is the key catalytic intermediate in Rad51-mediated recombination reactions...
  31. ncbi Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad54
    Markus Raschle
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 5730, USA
    J Biol Chem 279:51973-80. 2004
    In eukaryotes, Rad51 and Rad54 functionally cooperate to mediate homologous recombination and the repair of damaged chromosomes by recombination...
  32. pmc RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex
    Michael Chang
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    EMBO J 24:2024-33. 2005
    ..In addition, rmi1Delta strains fail to fully activate Rad53 upon exposure to DNA-damaging agents, suggesting that Rmi1 is also an important part of the Rad53-dependent DNA damage response...
  33. pmc Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae
    Akira Motegi
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Building 49, Room 4A22, Bethesda, MD 20892, USA
    Mol Cell Biol 26:1424-33. 2006
    ..We propose a mechanism for how defects in these proteins could lead to diverse outcomes (proper repair or GCR formation) through different regulation of DNA repair machinery...
  34. pmc Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein
    Kristina H Schmidt
    Department of Biology, University of South Florida, 4202 E Fowler Avenue, SCA110, Tampa, FL 33620, USA
    Mol Cell Biol 26:5406-20. 2006
    ..The translocation structures observed suggest involvement of a dicentric intermediate and break-induced replication with multiple cycles of DNA template switching...
  35. pmc The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation
    Cindy W Fung
    Graduate Program in Cellular, Molecular and Biophysical Studies, Columbia University Medical Center, New York, NY 10032, USA
    Mol Cell Biol 26:9544-54. 2006
    The nucleoprotein filament formed by Rad51 polymerization on single-stranded DNA is essential for homologous pairing and strand exchange...
  36. ncbi Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks
    Dana Branzei
    FIRC Institute of Molecular Oncology Foundation and Department of Biomedical Sciences and Biotechnology, Universita degli Studi di Milano, Via Adamello 16, 20139 Milan, Italy
    Cell 127:509-22. 2006
    ..ubc9 cells maintain stalled-fork stability but exhibit a Rad51-dependent accumulation of cruciform structures during replication of damaged templates...
  37. pmc Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication
    Sanchita Krishna
    Department of Molecular Genetics and Microbiology and Cancer Research and Treatment Center, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States
    DNA Repair (Amst) 6:797-808. 2007
    ..Interestingly, yku70Delta suppressed BIR in mre11 mutants. BIR is also elevated in rad51 mutants, but yku70Delta did not suppress BIR in a rad51 background...
  38. pmc Human peroxiredoxin PrxI is an orthologue of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae
    Ismail Iraqui
    UMR2027 Centre National de la Recherche Scientifique, Institut Curie, Centre Universitaire, Orsay, France
    Cancer Res 68:1055-63. 2008
    ..a variety of defects including genome instability, the synthetic lethality observed in rad6 Delta tsa1Delta and rad51 Delta tsa1Delta double mutants, and mutagen sensitivity...
  39. pmc RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae
    Nicholas R Pannunzio
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA 91010 0269, United States
    DNA Repair (Amst) 7:788-800. 2008
    ..The high frequency of these events suggests that SSA may be an important mechanism of genome rearrangement following acute radiation exposure...
  40. pmc Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA
    Edwin Antony
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell 35:105-15. 2009
    b>Rad51 is a DNA recombinase functioning in the repair of DNA double-strand breaks and the generation of genetic diversity by homologous recombination (HR)...
  41. pmc Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediator and the Srs2 anti-recombinase
    Changhyun Seong
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 284:24363-71. 2009
    ..The Rad51 recombinase, a member of the RAD52 group of recombination proteins, catalyzes the homologous recombination ..
  42. pmc Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase
    R Chanet
    Institut Curie, Centre National de la Recherche Scientifique, Paris, France
    Mol Cell Biol 16:4782-9. 1996
    ..negative semidominant for radiation sensitivity; presumably the mutant proteins are coassembled with wild-type Rad51 and poison the resulting nucleofilaments or recombination complexes...
  43. pmc Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae
    E L Ivanov
    Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02254 9110, USA
    Genetics 142:693-704. 1996
    ..We show that RAD51, RAD54, RAD55, and RAD57 genes are not required for SSA irrespective of whether recombination occurred in plasmid ..
  44. pmc DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway
    M E Dresser
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Genetics 147:533-44. 1997
    ..Epistasis analysis suggests that DMC1 and RAD51 function in separate pathways responsible for meiotic recombination...
  45. pmc A novel allele of RAD52 that causes severe DNA repair and recombination deficiencies only in the absence of RAD51 or RAD59
    Y Bai
    Department of Microbiology and Institute of Cancer Research, Columbia University, New York, New York 10032, USA
    Genetics 153:1117-30. 1999
    ..we have shown that mitotic recombination is dependent on the RAD52 gene, but reduced only fivefold by mutation of RAD51. RAD59, a component of the RAD51-independent pathway, was identified previously by screening for mutations that ..
  46. pmc Molecular dissection of interactions between Rad51 and members of the recombination-repair group
    L Krejci
    Department of Analysis of Biologically Important Molecular Complexes, Masaryk University, 612 65 Brno, Czech Republic
    Mol Cell Biol 21:966-76. 2001
    ..In the yeast Saccharomyces cerevisiae, recombination requires products of the RAD52 epistasis group. The Rad51 protein associates with the Rad51, Rad52, Rad54, and Rad55 proteins to form a dynamic complex...
  47. pmc Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events
    Q Chen
    Department of Molecular Biology and Genetics, Graduate Program in Cell and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 21:1819-27. 2001
    ..RAD52 is essential for the generation of both types of survivors. Deletion of both RAD50 and RAD51 produces a phenotype similar to that produced by deletion of RAD52...
  48. pmc Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break
    L Signon
    Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02254 9110, USA
    Mol Cell Biol 21:2048-56. 2001
    ..absence of RAD52, repair is nearly absent and diploid cells lose the broken chromosome; however, in cells lacking RAD51, gene conversion is absent but cells can repair the DSB by BIR...
  49. pmc Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexes
    Gary S Fortin
    Institute of Cancer Research and Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    EMBO J 21:3160-70. 2002
    Yeast Rad51 promotes homologous pairing and strand exchange in vitro, but this activity is inefficient in the absence of the accessory proteins, RPA, Rad52, Rad54 and the Rad55-Rad57 heterodimer...
  50. ncbi Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase
    Moreshwar B Vaze
    Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Mol Cell 10:373-85. 2002
    ..Permanent preanaphase arrest of srs2Delta cells is reversed by the addition of caffeine after cells have arrested. Thus, in addition to its roles in recombination, Srs2p appears to be needed to turn off the DNA damage checkpoint...
  51. pmc Transcription and double-strand breaks induce similar mitotic recombination events in Saccharomyces cerevisiae
    Sergio González-Barrera
    Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, Spain
    Genetics 162:603-14. 2002
    ..Gene conversions and inversions were differently affected by rad1, rad51, rad52, and rad59 single and double mutations, consistent with the actual view that such events occur by different ..
  52. ncbi Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51-ssDNA nucleoprotein filament
    Andrei Alexeev
    Division of Biological Sciences, Center for Genetics and Development, University of California, Davis, California 95616 8665, USA
    Nat Struct Biol 10:182-6. 2003
    ..the Rad54 protein participates in the recombinational repair of double-strand DNA breaks together with the Rad51, Rad52, Rad55 and Rad57 proteins...
  53. pmc Multiple recombination pathways for sister chromatid exchange in Saccharomyces cerevisiae: role of RAD1 and the RAD52 epistasis group genes
    Zheng Dong
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208 3479, USA
    Nucleic Acids Res 31:2576-85. 2003
    ..In comparison with wild type, rates of spontaneous SCE are 10-fold lower in rad51 rad1 but not in either rad51 rad50 or rad51 rad59 double mutants...
  54. ncbi Crystal structure of a Rad51 filament
    Adam B Conway
    Department of Biochemistry and Molecular Biology, The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Nat Struct Mol Biol 11:791-6. 2004
    b>Rad51, the major eukaryotic homologous recombinase, is important for the repair of DNA damage and the maintenance of genomic diversity and stability...
  55. pmc DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
    Grzegorz Ira
    Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Nature 431:1011-7. 2004
    ..to 3' resection of DSB ends and for the recruitment of both the single-stranded DNA-binding complex, RPA, and the Rad51 recombination protein. In contrast, Mre11 protein, part of the MRX complex, accumulates at unresected DSB ends...
  56. ncbi Gly-103 in the N-terminal domain of Saccharomyces cerevisiae Rad51 protein is critical for DNA binding
    Xiao ping Zhang
    Section of Microbiology, University of California, Davis, California 95616 8665, USA
    J Biol Chem 280:26303-11. 2005
    b>Rad51 is a homolog of the bacterial RecA protein and is central for recombination in eukaryotes performing homology search and DNA strand exchange...
  57. pmc Roles of SGS1, MUS81, and RAD51 in the repair of lagging-strand replication defects in Saccharomyces cerevisiae
    Miki Ii
    Department of Molecular Biology and Biochemistry, Rutgers University, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Curr Genet 48:213-25. 2005
    ..and the MUS81 structure-specific endonuclease display a synthetic lethality that is suppressed by loss of the RAD51 recombinase...
  58. pmc Suppression of spontaneous genome rearrangements in yeast DNA helicase mutants
    Kristina H Schmidt
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:18196-201. 2006
    ..Moreover, helicase double mutants accumulate Rad51-dependent Ddc2 foci, indicating the presence of recombination intermediates that are sensed by checkpoints...
  59. pmc Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres
    Brietta L Pike
    St Vincent s Institute of Medical Research, 9 Princes Street, Fitzroy, VIC 3065, Australia
    Mol Cell Biol 27:6532-45. 2007
    ....
  60. pmc Rad51-independent interchromosomal double-strand break repair by gene conversion requires Rad52 but not Rad55, Rad57, or Dmc1
    Thomas J Pohl
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Mol Cell Biol 28:897-906. 2008
    ..In yeast, HR is catalyzed by the Rad51 strand transferase and its "mediators," including the Rad52 single-strand DNA-annealing protein, two Rad51 ..
  61. doi The Srs2 helicase activity is stimulated by Rad51 filaments on dsDNA: implications for crossover incidence during mitotic recombination
    Pauline Dupaigne
    Laboratorie de Microscopie Moléculaire et Cellulaire, UMR 8126, Interactions Moléculaires et Cancer CNRS Université Paris Sud Institut de Cancérologie Gustave Roussy, Villejuif, France
    Mol Cell 29:243-54. 2008
    Saccharomyces cerevisiae Srs2 helicase was shown to displace Rad51 in vitro upon translocation on single-stranded DNA...
  62. pmc Rad51 protein controls Rad52-mediated DNA annealing
    Yun Wu
    Sections of Microbiology and of Molecular and Cellular Biology, University of California, Davis, CA 95616 8665, USA
    J Biol Chem 283:14883-92. 2008
    ..Here we report that the S. cerevisiae DNA strand exchange protein, Rad51, prevents Rad52-mediated annealing of complementary ssDNA...
  63. pmc Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications
    Ji Young Hwang
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892 USA
    DNA Repair (Amst) 7:1426-36. 2008
    ....
  64. doi Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break
    Marian Kalocsay
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell 33:335-43. 2009
    ..DSB repair involves the sequential recruitment of repair factors to the DSBs, followed by Rad51-mediated homology probing, DNA synthesis, and ligation...
  65. doi The yeast Shu complex couples error-free post-replication repair to homologous recombination
    Lindsay G Ball
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5
    Mol Microbiol 73:89-102. 2009
    ..This mechanism appears to be conserved throughout eukaryotes...
  66. pmc Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption
    Sierra Colavito
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Nucleic Acids Res 37:6754-64. 2009
    ..Consistent with the genetic data, purified Srs2 strongly inhibits Rad51-mediated recombination reactions by disrupting the Rad51-ssDNA presynaptic filament...
  67. pmc Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation
    Hengyao Niu
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Mol Cell 36:393-404. 2009
    ..and the meiosis-specific kinase Mek1, which suppresses engagement of sister chromatids by the mitotic recombinase Rad51. Here, a combination of proteomic, biochemical, and genetic approaches has identified an additional role for Mek1 ..
  68. doi A postincision-deficient TFIIH causes replication fork breakage and uncovers alternative Rad51- or Pol32-mediated restart mechanisms
    María Moriel-Carretero
    Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla CSIC, Av Americo Vespucio s n, 41092 Sevilla, Spain
    Mol Cell 37:690-701. 2010
    ..are rescued by MRX-Rad52-Rfc1-dependent recombination via two types of replication restart mechanisms, one being Rad51 dependent and the other Pol32 dependent...
  69. pmc Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
    Eleni P Mimitou
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA
    EMBO J 29:3358-69. 2010
    ..Finally, we show that the presence of Ku exacerbates DNA end-processing defects established in the sae2Δ sgs1Δ mutant, leading to its lethality...
  70. doi Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair
    Clémentine Brocas
    CEA, DSV, IRCM, Bâtiment 05 BP6, Fontenay aux Roses, F 92265, France
    DNA Repair (Amst) 9:1098-111. 2010
    ..Taken together, our data highlight a stringent dependence on Pol δ complex stability in DNA repair...
  71. pmc The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase
    Kara A Bernstein
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Mol Biol Cell 22:1599-607. 2011
    The Shu complex, which contains RAD51 paralogues, is involved in the decision between homologous recombination and error-prone repair...
  72. pmc Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation
    Jie Liu
    Department of Microbiology, University of California, Davis, Davis, California 95616 8665, USA
    Nature 479:245-8. 2011
    ..The RecA/UvsX/RadA/Rad51 family of proteins catalyses the signature reactions of recombination, homology search and DNA strand invasion...
  73. doi Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection
    Kenichiro Matsuzaki
    Department of Integrated Protein Functions, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 17:473-93. 2012
    ..CDK-dependent modification of the NHEJ pathway might make DSB ends compatible for NHEJ and thus prevent competition between HR and NHEJ in hierarchy on the choice of DSB repair pathways...
  74. pmc The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation
    Vinay V Eapen
    Department of Biology, Rosenstiel Basic Medical Sciences Center, Brandeis University, Waltham, Massachusetts, USA
    Mol Cell Biol 32:4727-40. 2012
    ..Fun30 is not required for later steps in homologous recombination. Like its homolog Rdh54/Tid1, Fun30 is required to allow the adaptation of DNA damage checkpoint-arrested cells with an unrepaired DSB to resume cell cycle progression...
  75. pmc Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes
    Amaya Alzu
    The FIRC Institute of Molecular Oncology IFOM Foundation, Via Adamello 16, 20139 Milan, Italy
    Cell 151:835-46. 2012
    ....
  76. pmc Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating-type heterozygosity
    D Schild
    Life Sciences Division, Lawrence Berkeley Laboratory, California 94720, USA
    Genetics 140:115-27. 1995
    ..Because other researchers have shown that the RAD51 and RAD52 proteins interact, RAD51 on a high copy number plasmid was tested and found to suppress the rad52-20 ..
  77. pmc Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51
    G T Milne
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genetics 139:1189-99. 1995
    ..phenotypic null allele of SRS2 that suppressed multiple alleles of RAD52 (rad52B, rad52D, rad52-1 and KlRAD52) and RAD51 (KlRAD51) but failed to suppress either a rad52 delta or a rad51 delta...
  78. pmc Recombinational repair in yeast: functional interactions between Rad51 and Rad54 proteins
    B Clever
    Institute of General Microbiology, Bern, Switzerland
    EMBO J 16:2535-44. 1997
    ..Here we demonstrate by genetic, molecular and biochemical criteria that Rad51 and Rad54 proteins interact...
  79. ncbi Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase
    P Sung
    Department of Molecular Medicine and the Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    J Biol Chem 272:28194-7. 1997
    The RAD51 and RAD52 genes of Saccharomyces cerevisiae are key members of the RAD52 epistasis group required for genetic recombination and the repair of DNA double-stranded breaks...
  80. ncbi Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination
    A Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genes Cells 2:615-29. 1997
    b>Rad51 and Dmc1 are Saccharomyces cerevisiae homologues of the Escherichia coli recombination protein RecA...
  81. ncbi Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins
    G Petukhova
    Institute of Biotechnology and Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 78245, USA
    Nature 393:91-4. 1998
    The Saccharomyces cerevisiae RAD51 and RAD54 genes are both required for the occurrence of homologous recombination and for the repair of double-stranded DNA breaks...
  82. pmc Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1
    G Petukhova
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    Genes Dev 14:2206-15. 2000
    ..product, a Swi2/Snf2-like factor involved in recombination, is shown here to promote D-loop formation with Rad51 recombinase...
  83. pmc The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination
    M McVey
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 157:1531-42. 2001
    ..This arrest can be suppressed by mutations in RAD51, RAD52, and RAD57, suggesting that the cell cycle defect in sgs1 srs2 mutants results from inappropriate ..
  84. ncbi Interaction with Rad51 is indispensable for recombination mediator function of Rad52
    Lumir Krejci
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    J Biol Chem 277:40132-41. 2002
    ..Moreover, Rad52 physically interacts with the Rad51 recombinase and serves as a mediator in the Rad51-catalyzed DNA strand exchange reaction...
  85. pmc Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae
    Erika Shor
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032 2704, USA
    Genetics 162:647-62. 2002
    ..We found that slow growth and DNA damage sensitivity of top3 mutants are suppressed by mutations in RAD51, RAD54, RAD55, and RAD57...
  86. ncbi Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability
    Pamela Kanellis
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Curr Biol 13:1583-95. 2003
    ..Genome instability is a hallmark of cancer and plays a critical role in generating the myriad of phenotypes selected for during tumor progression. However, the mechanisms that prevent genome rearrangements remain poorly understood...
  87. ncbi The Rad52-Rad59 complex interacts with Rad51 and replication protein A
    Allison P Davis
    Department of Microbiology and Institute of Cancer Research, Columbia University College of Physicians and Surgeons, 701 W 168th St, New York, NY 10032, USA
    DNA Repair (Amst) 2:1127-34. 2003
    ..Rad52 forms complexes with Rad51, replication protein A (RPA) or Rad59 and its presence is essential for the formation of Rad51-Rad52-Rad59 and RPA-..
  88. pmc A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59
    Felipe Cortes-Ledesma
    Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, 41012, Spain
    Genetics 168:553-7. 2004
    ..These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52...
  89. pmc RAD51-dependent break-induced replication differs in kinetics and checkpoint responses from RAD51-mediated gene conversion
    Anna Malkova
    Rosenstiel Center, Brandeis University, 415 South St, Mail Stop 029, Waltham, MA 02454 9110, USA
    Mol Cell Biol 25:933-44. 2005
    ..Saccharomyces cells experiencing a double-strand break (DSB) on one homologous chromosome repair the break by RAD51-mediated gene conversion >98% of the time...
  90. ncbi SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase
    Boris Pfander
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nature 436:428-33. 2005
    ..SUMO-modified PCNA functionally cooperates with Srs2, a helicase that blocks recombinational repair by disrupting Rad51 nucleoprotein filaments...
  91. pmc Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast
    Jill M Henry
    The Stowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA
    Mol Cell Biol 26:2913-23. 2006
    ..Recombination in meiosis in Saccharomyces cerevisiae relies on two Escherichia coli recA homologs, Rad51 and Dmc1, as well as the more recently discovered heterodimer Mnd1/Hop2. Meiotic recombination in S...
  92. pmc Complex minisatellite rearrangements generated in the total or partial absence of Rad27/hFEN1 activity occur in a single generation and are Rad51 and Rad52 dependent
    Judith Lopes
    Recombinaison et Instabilité Génétique, Institut Curie Centre de Recherche, UMR7147 CNRS UPMC, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Mol Cell Biol 26:6675-89. 2006
    ..of the rad27Delta mutation by hFEN1 demonstrated that the production of novel CEB1 alleles is Rad52 and Rad51 dependent...
  93. ncbi The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast
    Karine Dubrana
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Cell Sci 120:4209-20. 2007
    ..Conversely, loss of Rad51 enhanced Mec1 focus formation independently of ssDNA formation, suggesting that Rad51 might compete for the ..
  94. pmc Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination
    Amy M Mozlin
    Department of Microbiology, Columbia University Medical Center, New York, New York 10032, USA
    Genetics 178:113-26. 2008
    b>Rad51 requires a number of other proteins, including the Rad51 paralogs, for efficient recombination in vivo...
  95. pmc Hed1 regulates Rad51-mediated recombination via a novel mechanism
    Valeria Busygina
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 22:786-95. 2008
    Two RecA orthologs, Rad51 and Dmc1, mediate homologous recombination in meiotic cells. During budding yeast meiosis, Hed1 coordinates the actions of Rad51 and Dmc1 by down-regulating Rad51 activity...
  96. pmc A Rad51 presynaptic filament is sufficient to capture nucleosomal homology during recombinational repair of a DNA double-strand break
    Manisha Sinha
    Program in Molecular Medicine, Interdisciplinary Graduate Program, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell 30:803-10. 2008
    ..Thus, contrary to popular belief, nucleosomes do not pose a potent barrier for successful recognition and capture of homology by an invading presynaptic filament...
  97. pmc Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity
    Iben Plate
    Center for Microbial Biotechnology, Technical University of Denmark, Lyng by 2800, Denmark
    J Biol Chem 283:29077-85. 2008
    ..HR is catalyzed by proteins encoded by genes of the RAD52 epistasis group, including the recombinase Rad51 and its mediator Rad52...
  98. pmc SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination
    Alix Kerrest
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR 927, 25 rue du Dr Roux, F 75015 Paris, France
    Nat Struct Mol Biol 16:159-67. 2009
    ..Deletion of RAD52 or RAD51 suppresses these phenotypes, suggesting that recombination triggers trinucleotide repeat instability in srs2Delta ..
  99. pmc Role of the Rad52 amino-terminal DNA binding activity in DNA strand capture in homologous recombination
    Idina Shi
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 284:33275-84. 2009
    Saccharomyces cerevisiae Rad52 protein promotes homologous recombination by nucleating the Rad51 recombinase onto replication protein A-coated single-stranded DNA strands and also by directly annealing such strands...
  100. pmc Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast
    Yi Hsuan Lin
    Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 4:e8224. 2009
    ..we also observed that when cells equipped with short telomeres, recruitments of homologous recombination proteins, Rad51 and Rad52, were reduced at an HO-endonuclease-catalyzed double-strand break (DSB), while their associations were ..
  101. pmc Rad52 SUMOylation affects the efficiency of the DNA repair
    Veronika Altmannova
    Department of Biology, Masaryk University, Brno, Czech Republic
    Nucleic Acids Res 38:4708-21. 2010
    ..Taken together, our results highlight the importance of Rad52 SUMOylation as part of a 'quality control' mechanism regulating the efficiency of recombination and DNA repair...

Research Grants7

  1. GENOME STABILITY IN RAD MUTANTS
    ADAM BAILIS; Fiscal Year: 2006
    ..This combination of genetic and physical methods will promote a more thorough understanding of several of the molecular interactions critical for SSR, and the maintenance of genome stability. ..
  2. RADIATION INDUCTION OF GENOMIC REARRANGEMENTS IN YEAST
    Michael Fasullo; Fiscal Year: 2004
    ..abstract_text> ..
  3. Genetic Recombination/Genomic Rearrangements Conference
    LORRAINE SYMINGTON; Fiscal Year: 2005
    ..abstract_text> ..
  4. Repair Pathways for Ionizing Radiation Damage Yeast
    John Game; Fiscal Year: 2006
    ..Recent and existing mutants will be studied in detail with this system to determine the molecular involvement of each gene in DSB repair, sister chromatid exchange and recombination between chromosomes. ..
  5. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Genetic Recombination and Chromosome Rearrangements
    LORRAINE SYMINGTON; Fiscal Year: 2007
    ..the product of the BRCA2 gene, which is mutated in a subset of hereditary breast cancers, interacts directly with Rad51 and is essential for homologous recombination...
  7. Mechanisms of Double-strand Break Repair in Yeast
    LORRAINE SYMINGTON; Fiscal Year: 2009
    ..Central to this process is the Rad51 complex with ssDNA, which is active in the homology search and strand exchange phases of the reaction...

Patents1

  1. Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
    Patent Number: EP0659766-A1; Date:1995-06-28