CBL2

Summary

Gene Symbol: CBL2
Description: calcineurin B-like protein 2
Alias: ATCBL2, MDA7.3, MDA7_3, SCaBP1, SOS3-LIKE CALCIUM BINDING PROTEIN 1, calcineurin B-like protein 2
Species: thale cress

Top Publications

  1. doi PKS5, a SNF1-related kinase, interacts with and phosphorylates NPR1, and modulates expression of WRKY38 and WRKY62
    Changgen Xie
    College of Life Sciences, Peking University, Beijing, China
    J Genet Genomics 37:359-69. 2010
  2. doi Calcineurin B-like 3 calcium sensor associates with and inhibits 5'-methylthioadenosine nucleosidase 2 in Arabidopsis
    Sung Han Ok
    Department of Molecular Biology, PERI, Sejong University, Seoul 143 747, Republic of Korea
    Plant Sci 238:228-40. 2015
  3. pmc Calcineurin B-Like Protein-Interacting Protein Kinase CIPK21 Regulates Osmotic and Salt Stress Responses in Arabidopsis
    Girdhar K Pandey
    Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India G K P, P K, A s, A P, A K Y, I T, S K S Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universitat Munster, 48149 Muenster, Germany L S, J K Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560 500, Korea B G K Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 B G K, S C L, Y H C, S L Department of Life Science, Chung Ang University, Heukseok Dong, Dongjak Gu, Seoul 156 756, Korea S C L andDepartment of Bio Environmental Science, Sunchon National University, Suncheon, Jeonnam 540 742, Korea Y H C
    Plant Physiol 169:780-92. 2015
  4. doi Vacuolar CBL-CIPK12 Ca(2+)-sensor-kinase complexes are required for polarized pollen tube growth
    Leonie Steinhorst
    Institut für Biologie und Biotechnologie der Pflanzen, Westfalische Wilhelms Universitat, 48149 Munster, Germany
    Curr Biol 25:1475-82. 2015
  5. pmc Tonoplast CBL-CIPK calcium signaling network regulates magnesium homeostasis in Arabidopsis
    Ren Jie Tang
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720
    Proc Natl Acad Sci U S A 112:3134-9. 2015
  6. doi Arabidopsis CIPK14 positively regulates glucose response
    Jingli Yan
    State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau and, College of Life Sciences, Northwest A and F University, Yangling, Shaanxi 712100, China Electronic address
    Biochem Biophys Res Commun 450:1679-83. 2014
  7. pmc A calcium-independent activation of the Arabidopsis SOS2-like protein kinase24 by its interacting SOS3-like calcium binding protein1
    Huixin Lin
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China
    Plant Physiol 164:2197-206. 2014
  8. doi The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana
    Christian Eckert
    Institut für Biologie und Biotechnologie der Pflanzen, Universitat Munster, Schlossplatz 4, 48149, Munster, Germany
    Plant J 78:146-56. 2014
  9. ncbi Variable interactions between sucrose non-fermented 1-related protein kinases and regulatory proteins in higher plants
    Akira Nozawa
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Japan
    Biosci Biotechnol Biochem 67:2533-40. 2003
  10. pmc A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis
    Li li Liu
    State Key Laboratory of Plant Physiology and Biochemistry, National Plant Gene Research Centre, College of Biological Sciences, China Agricultural University, Beijing 100193, China
    Plant Physiol 161:266-77. 2013

Scientific Experts

  • Girdhar K Pandey
  • Changgen Xie
  • Sheng Luan
  • Jorg Kudla
  • Oliver Batistic
  • Leonie Steinhorst
  • Huixin Lin
  • Stefanie Schültke
  • Wenming Du
  • Yan Guo
  • Wen Zhi Lan
  • Anja T Fuglsang
  • Sung Chul Lee
  • Ren Jie Tang
  • Sung Han Ok
  • Ingo Heilmann
  • Chunxia Zhang
  • Jingli Yan
  • Christian Eckert
  • Li li Liu
  • Yuan Qing Jiang
  • Karen S Schumaker
  • Liming Zhou
  • Michael G Palmgren
  • Mayuko Akaboshi
  • V Albrecht
  • Nozomu Koizumi
  • Akira Nozawa
  • Fu Geng Zhao
  • Joo Hyuk Cho
  • Mi Na Choi
  • Hong Xia Zhang
  • Jae Yeon Ma
  • Xinxin Zhang
  • Thomas J Kleist
  • Sibylle Arendt
  • Lei Yang
  • Till Ischebeck
  • Anette Mähs
  • Veder J Garcia
  • Seung Ick Oh
  • Kyung Nam Kim
  • Jeong Sheop Shin
  • Bo Yang
  • Stefan Hillmer
  • Yongqing Yang
  • Tobias Heinz
  • Karin Schumacher
  • Wenzhi Lan
  • Ralph Bock
  • Hanfeng Zhang
  • Yufen Che
  • Jan Niklas Offenborn
  • Boya Wang
  • Wu Zhen Liu
  • Mareike Heilmann
  • Tegan Armarego-Marriott
  • Fangfang Niu
  • Li Qing Chen
  • Yi Wang
  • Hui Min Ren
  • Wei Hua Wu
  • Y Guo
  • A Nozawa
  • Yu Fen Che
  • She Chen
  • Weihua Wu
  • Jun Zhang
  • Yisheng Wu
  • O Ritz
  • Rainer Waadt
  • J Kudla
  • K Harter
  • Katrin Held
  • Ying Fu
  • Zhenbiao Yang
  • Hanako Ishida
  • Toshiyuki Shimizu
  • Mamoru Sato
  • Shaul Yalovsky
  • Shinya Saijo
  • Nadav Sorek
  • J Shi
  • Hiroshi Hashimoto
  • Jian Kang Zhu
  • Sergey Shabala
  • Kim A Kristiansen
  • Guihua Lu
  • Beom Gi Kim
  • Legong Li

Detail Information

Publications22

  1. doi PKS5, a SNF1-related kinase, interacts with and phosphorylates NPR1, and modulates expression of WRKY38 and WRKY62
    Changgen Xie
    College of Life Sciences, Peking University, Beijing, China
    J Genet Genomics 37:359-69. 2010
    ..Our results suggest that PKS5 functions at the upstream of NPR1 and might mediate expression of WRKY38 and WRKY62 possibly by interacting with and phosphorylating NPR1...
  2. doi Calcineurin B-like 3 calcium sensor associates with and inhibits 5'-methylthioadenosine nucleosidase 2 in Arabidopsis
    Sung Han Ok
    Department of Molecular Biology, PERI, Sejong University, Seoul 143 747, Republic of Korea
    Plant Sci 238:228-40. 2015
    ..In the yeast two-hybrid system, AtMTAN1 interacted with multiple CBL members such as CBL2, CBL3 and CBL6, whereas AtMTAN2 associated exclusively with CBL3...
  3. pmc Calcineurin B-Like Protein-Interacting Protein Kinase CIPK21 Regulates Osmotic and Salt Stress Responses in Arabidopsis
    Girdhar K Pandey
    Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India G K P, P K, A s, A P, A K Y, I T, S K S Molekulargenetik und Zellbiologie der Pflanzen Institut für Biologie und Biotechnologie der Pflanzen, Universitat Munster, 48149 Muenster, Germany L S, J K Department of Molecular Breeding, National Academy of Agricultural Science, Jeonju 560 500, Korea B G K Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 B G K, S C L, Y H C, S L Department of Life Science, Chung Ang University, Heukseok Dong, Dongjak Gu, Seoul 156 756, Korea S C L andDepartment of Bio Environmental Science, Sunchon National University, Suncheon, Jeonnam 540 742, Korea Y H C
    Plant Physiol 169:780-92. 2015
    ..The calcium sensors CBL2 and CBL3 were found to physically interact with CIPK21 and target this kinase to the tonoplast...
  4. doi Vacuolar CBL-CIPK12 Ca(2+)-sensor-kinase complexes are required for polarized pollen tube growth
    Leonie Steinhorst
    Institut für Biologie und Biotechnologie der Pflanzen, Westfalische Wilhelms Universitat, 48149 Munster, Germany
    Curr Biol 25:1475-82. 2015
    ..Here we identified the two closely related tonoplast-localized Ca(2+)-sensor proteins CBL2 and CBL3 as crucial regulators of vacuolar dynamics and polarized pollen tube growth...
  5. pmc Tonoplast CBL-CIPK calcium signaling network regulates magnesium homeostasis in Arabidopsis
    Ren Jie Tang
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720
    Proc Natl Acad Sci U S A 112:3134-9. 2015
    ..In this study, we identified two calcineurin B-like (CBL) proteins, CBL2 and CBL3, as key regulators for plant growth under high-Mg conditions...
  6. doi Arabidopsis CIPK14 positively regulates glucose response
    Jingli Yan
    State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau and, College of Life Sciences, Northwest A and F University, Yangling, Shaanxi 712100, China Electronic address
    Biochem Biophys Res Commun 450:1679-83. 2014
    ..1 and SnRK1.2 implicated in glucose signaling. This is the first report to demonstrate that CIPK also plays a role in glucose signaling. ..
  7. pmc A calcium-independent activation of the Arabidopsis SOS2-like protein kinase24 by its interacting SOS3-like calcium binding protein1
    Huixin Lin
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China
    Plant Physiol 164:2197-206. 2014
    ..Here, we report the calcium-independent activation of PKS24 by SCaBP1 and show that activation is dependent on interaction of PKS24 with the C-terminal tail of SCaBP1...
  8. doi The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana
    Christian Eckert
    Institut für Biologie und Biotechnologie der Pflanzen, Universitat Munster, Schlossplatz 4, 48149, Munster, Germany
    Plant J 78:146-56. 2014
    ..In this study, we analyzed single and double mutants of the closely related tonoplast-localized calcium sensors CBL2 and CBL3, which show either reduction of function (rf) or complete loss of function (lf)...
  9. ncbi Variable interactions between sucrose non-fermented 1-related protein kinases and regulatory proteins in higher plants
    Akira Nozawa
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Japan
    Biosci Biotechnol Biochem 67:2533-40. 2003
    ..This was also the case for AtWL1 and AtWL2, showing an efficient interaction with AtCBL2. In contrast, WPK4 interacted with none of the CBLs...
  10. pmc A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis
    Li li Liu
    State Key Laboratory of Plant Physiology and Biochemistry, National Plant Gene Research Centre, College of Biological Sciences, China Agricultural University, Beijing 100193, China
    Plant Physiol 161:266-77. 2013
    ..Furthermore, CBL2 and CBL3 were identified as upstream regulators of CIPK9...
  11. pmc A protein phosphorylation/dephosphorylation network regulates a plant potassium channel
    Sung Chul Lee
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:15959-64. 2007
    ....
  12. pmc Dual fatty acyl modification determines the localization and plasma membrane targeting of CBL/CIPK Ca2+ signaling complexes in Arabidopsis
    Oliver Batistic
    Institut fur Botanik, Universitat Munster, 48149 Munster, Germany
    Plant Cell 20:1346-62. 2008
    ..Our findings demonstrate the importance of S-acylation for regulating the spatial accuracy of Ca2+-decoding proteins and suggest a novel mechanism that enables the functional specificity of calcium sensor/kinase complexes...
  13. doi A genome-wide functional characterization of Arabidopsis regulatory calcium sensors in pollen tubes
    Liming Zhou
    State Key Laboratory of Plant Physiology and Biochemistry, Department of Plant Sciences, College of Biological Sciences, China Agricultural University, Beijing, China
    J Integr Plant Biol 51:751-61. 2009
    ..CDPK32-GFP caused severe growth depolarization. CBL2-GFP and CBL3-GFP exhibited dynamic patterns of subcellular localization, including several endomembrane ..
  14. doi CBL-mediated targeting of CIPKs facilitates the decoding of calcium signals emanating from distinct cellular stores
    Oliver Batistic
    Institut fur Botanik, Universitat Munster, Schlossplatz 4, 48149 Munster, Germany
    Plant J 61:211-22. 2010
    ....
  15. pmc Novel protein kinases associated with calcineurin B-like calcium sensors in Arabidopsis
    J Shi
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 11:2393-405. 1999
    ..These findings link a new type of Ca(2)+ sensors to a group of novel protein kinases, providing the molecular basis for a unique Ca(2)+ signaling machinery in plant cells...
  16. doi Mechanistic analysis of AKT1 regulation by the CBL-CIPK-PP2CA interactions
    Wen Zhi Lan
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Mol Plant 4:527-36. 2011
    ..These findings provide further insights into the signaling network consisting of CBL-CIPK-PP2C interactions in the activation of the AKT1 channel...
  17. pmc Phosphorylation of SOS3-like calcium-binding proteins by their interacting SOS2-like protein kinases is a common regulatory mechanism in Arabidopsis
    Wenming Du
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China
    Plant Physiol 156:2235-43. 2011
    ..The phosphorylation site serine-216 at the C terminus of SCaBP1 by PKS24 was identified by liquid chromatography-quadrupole mass spectrometry analysis...
  18. doi The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14
    Mayuko Akaboshi
    International Graduate School of Arts and Sciences, Yokohama City University, 1 7 29 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Mol Biol 377:246-57. 2008
    ..To better understand the functional role of the CBL-CIPK system, we determined the crystal structure of AtCBL2 in complex with the regulatory domain of AtCIPK14 at 1.2 A resolution...
  19. pmc Arabidopsis protein kinase PKS5 inhibits the plasma membrane H+ -ATPase by preventing interaction with 14-3-3 protein
    Anja T Fuglsang
    Department of Plant Biology, University of Copenhagen, DK 1871 Frederiksberg C, Denmark
    Plant Cell 19:1617-34. 2007
    ..We show that PKS5 interacts with the calcium binding protein SCaBP1 and that high external pH can trigger an increase in the concentration of cytosolic-free calcium...
  20. ncbi An Arabidopsis SNF1-related protein kinase, AtSR1, interacts with a calcium-binding protein, AtCBL2, of which transcripts respond to light
    A Nozawa
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara, 630 0101 Japan
    Plant Cell Physiol 42:976-81. 2001
    ..and six calcineurin B like proteins of Arabidopsis and found that AtSR1 prominently interacts with one of them, AtCBL2, by yeast two-hybrid assay...
  21. pmc Molecular characterization of functional domains in the protein kinase SOS2 that is required for plant salt tolerance
    Y Guo
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Plant Cell 13:1383-400. 2001
    ..Combining the Thr(168)-to-Asp mutation with the autoinhibitory domain deletion created a superactive SOS2 kinase. These results provide insights into regulation of the kinase activities of SOS2 and the SOS2 family of protein kinases...
  22. pmc The NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases
    V Albrecht
    Universitat Ulm, Molekulare Botanik, Albert Einstein Allee 11, D 89069 Ulm, Germany
    EMBO J 20:1051-63. 2001
    ..Mutation of conserved residues either abolished or significantly diminished the affinity of AtCIPK1 for AtCBL2. Comprehensive two-hybrid screens with various AtCBLs identified 15 CIPKs as potential targets of CBL proteins...