CCA1

Summary

Gene Symbol: CCA1
Description: circadian clock associated 1
Alias: AtCCA1, F19D11.11, MYB-RELATED DNA BINDING PROTEIN, circadian clock associated 1
Species: thale cress

Top Publications

  1. ncbi Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression
    Z Y Wang
    Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, California 90095 1606, USA
    Cell 93:1207-17. 1998
  2. pmc The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
    Alexandra Pokhilko
    School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Syst Biol 8:574. 2012
  3. doi Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis
    Gang Li
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nat Cell Biol 13:616-22. 2011
  4. pmc The functional interplay between protein kinase CK2 and CCA1 transcriptional activity is essential for clock temperature compensation in Arabidopsis
    Sergi Portolés
    Consortium CSIC IRTA UAB, Centre for Research in Agricultural Genomics, Department of Plant Molecular Genetics, Barcelona, Spain
    PLoS Genet 6:e1001201. 2010
  5. pmc Posttranslational regulation of CIRCADIAN CLOCK ASSOCIATED1 in the circadian oscillator of Arabidopsis
    Esther Yakir
    Department of Plant and Environmental Sciences, The Silberman Institute for Life Sciences, The Hebrew University, Givat Ram, Jerusalem 91904, Israel
    Plant Physiol 150:844-57. 2009
  6. ncbi ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY
    Elise A Kikis
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant J 44:300-13. 2005
  7. ncbi Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock
    Eva M Farré
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 15:47-54. 2005
  8. pmc CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis
    Xavier Daniel
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095 1606, USA
    Proc Natl Acad Sci U S A 101:3292-7. 2004
  9. pmc The protein kinase CK2 is involved in regulation of circadian rhythms in Arabidopsis
    S Sugano
    Department of Molecular Biology, University of California, Los Angeles, CA 90095 1606, USA
    Proc Natl Acad Sci U S A 96:12362-6. 1999
  10. ncbi Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock
    D Alabadi
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 293:880-3. 2001

Scientific Experts

  • Haitao Shi
  • Shunhong Dai
  • Norihito Nakamichi
  • Tsuyoshi Mizoguchi
  • Takafumi Yamashino
  • Takeshi Mizuno
  • Pil Joon Seo
  • Kanae Niinuma
  • Elaine M Tobin
  • Shogo Ito
  • Sheen X Lu
  • Kana Miyata
  • Mari Kamioka
  • Esther Yakir
  • Zhaojun Ding
  • Mi Jeong Park
  • Gang Li
  • On Sun Lau
  • Steve A Kay
  • C Robertson McClung
  • Stephen M Knowles
  • Riichiro Yoshida
  • Hae Ryong Song
  • Christos Andronis
  • Sumire Fujiwara
  • Andrew J Millar
  • Costas Delis
  • Eva M Farré
  • Yusuke Niwa
  • Dawn H Nagel
  • Hong Gil Lee
  • George Coupland
  • QiGuang Xie
  • Colleen J Doherty
  • Polly Yingshan Hsu
  • Chung Mo Park
  • Hans Hemmes
  • Hanayo Ueoka-Nakanishi
  • Alexandra Pokhilko
  • Alvina Grace Lai
  • Juan de Dios Barajas-López
  • Xing Wang Deng
  • Xiaodong Xu
  • Malia A Dong
  • Wei Wang
  • Alona Ovadia
  • Eri Ogiso
  • Sergi Portolés
  • Patrice A Salome
  • Estelle Giraud
  • Z Y Wang
  • Stacey L Harmer
  • Mayu Nakagawa
  • Kounosuke Hayashi
  • Yusuke Tomozoe
  • Atsushi Oda
  • Rodrigo A Gutierrez
  • Masakazu Kawamura
  • Miriam Hassidim
  • Dror Hilman
  • Rachel M Green
  • Seth J Davis
  • S Sugano
  • Masanori Kita
  • Shoji Sugano
  • E M Tobin
  • Toru Fujimori
  • Elise A Kikis
  • Xavier Daniel
  • Simon C Thain
  • Kyomi Taki
  • Rafailia A A Beta
  • Saori Takao
  • Takamasa Suzuki
  • Afrodite Krokida
  • Kalliope K Papadopoulou
  • Anastasia Tomatsidou
  • Nikolaos A A Balatsos
  • Daniela Tsikou
  • Demetres D Leonidas
  • Georgios Stravodimos
  • Maria Tsioumpekou
  • Toshinori Kinoshita
  • Tetsuya Higashiyama
  • Julietta Moustaka
  • Kyounghee Lee
  • Joseph R Ecker
  • Robert J Schmitz
  • Jose L Pruneda-Paz
  • Kiyoung Jang

Detail Information

Publications52

  1. ncbi Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression
    Z Y Wang
    Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, California 90095 1606, USA
    Cell 93:1207-17. 1998
    The CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene encodes a MYB-related transcription factor involved in the phytochrome induction of a light-harvesting chlorophyll a/b-protein (Lhcb) gene...
  2. pmc The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
    Alexandra Pokhilko
    School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Syst Biol 8:574. 2012
    ..As well as matching timeseries and phase-response data, the model provides a new conceptual framework for the plant clock that includes a three-component repressilator circuit in its complex structure...
  3. doi Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis
    Gang Li
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nat Cell Biol 13:616-22. 2011
    ..component of the central oscillator, and activate its expression during the day, whereas the circadian-controlled CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn through physical interactions with these ..
  4. pmc The functional interplay between protein kinase CK2 and CCA1 transcriptional activity is essential for clock temperature compensation in Arabidopsis
    Sergi Portolés
    Consortium CSIC IRTA UAB, Centre for Research in Agricultural Genomics, Department of Plant Molecular Genetics, Barcelona, Spain
    PLoS Genet 6:e1001201. 2010
    ..a previously unpredicted mechanism for CK2 antagonizing the key clock regulator CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1)...
  5. pmc Posttranslational regulation of CIRCADIAN CLOCK ASSOCIATED1 in the circadian oscillator of Arabidopsis
    Esther Yakir
    Department of Plant and Environmental Sciences, The Silberman Institute for Life Sciences, The Hebrew University, Givat Ram, Jerusalem 91904, Israel
    Plant Physiol 150:844-57. 2009
    ..CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYLS (LHY) are closely related single myb transcription factors that have been identified ..
  6. ncbi ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY
    Elise A Kikis
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant J 44:300-13. 2005
    ..has been presented that a negative transcriptional feedback loop formed by the genes CIRCADIAN CLOCK ASSOCIATED (CCA1), LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB (TOC1) constitutes the core of the central oscillator of the ..
  7. ncbi Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock
    Eva M Farré
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 15:47-54. 2005
    ..In plants, the first suggested regulatory loop involves the transcription factors CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) and the pseudo-response regulator TIMING OF CAB EXPRESSION 1 (TOC1/PRR1)...
  8. pmc CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis
    Xavier Daniel
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095 1606, USA
    Proc Natl Acad Sci U S A 101:3292-7. 2004
    ..shown that in Arabidopsis, the protein kinase CK2 can phosphorylate the clock-associated protein CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) in vitro...
  9. pmc The protein kinase CK2 is involved in regulation of circadian rhythms in Arabidopsis
    S Sugano
    Department of Molecular Biology, University of California, Los Angeles, CA 90095 1606, USA
    Proc Natl Acad Sci U S A 96:12362-6. 1999
    ..The circadian clock-associated 1 (CCA1) and the late elongated hypocotyl (LHY) proteins have been shown to be closely associated with clock function in ..
  10. ncbi Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock
    D Alabadi
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 293:880-3. 2001
    ..Here, we show interactions between the Arabidopsis clock genes LATE ELONGATED HYPOCOTYL (LHY), CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), and TIMING OF CAB EXPRESSION 1 (TOC1)...
  11. pmc Protein kinase CK2 interacts with and phosphorylates the Arabidopsis circadian clock-associated 1 protein
    S Sugano
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095 1606, USA
    Proc Natl Acad Sci U S A 95:11020-5. 1998
    The circadian clock-associated 1 (CCA1) gene encodes a Myb-related transcription factor that has been shown to be involved in the phytochrome regulation of Lhcb1*3 gene expression and in the function of the circadian oscillator in ..
  12. pmc A Myb-related transcription factor is involved in the phytochrome regulation of an Arabidopsis Lhcb gene
    Z Y Wang
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles 90095 1606, USA
    Plant Cell 9:491-507. 1997
    We have isolated the gene for a protein designated CCA1. This protein can bind to a region of the promoter of an Arabidopsis light-harvesting chlorophyll a/b protein gene, Lhcb1*3, which is necessary for its regulation by phytochrome...
  13. ncbi LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis
    Tsuyoshi Mizoguchi
    John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Dev Cell 2:629-41. 2002
    ..LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved...
  14. pmc A complex genetic interaction between Arabidopsis thaliana TOC1 and CCA1/LHY in driving the circadian clock and in output regulation
    Zhaojun Ding
    Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Genetics 176:1501-10. 2007
    It has been proposed that CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) together with TIMING OF CAB EXPRESSION 1 (TOC1) make up the central oscillator of the Arabidopsis thaliana circadian clock...
  15. pmc AtHESPERIN: a novel regulator of circadian rhythms with poly(A)-degrading activity in plants
    Costas Delis
    a Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, 412 21, Greece
    RNA Biol 13:68-82. 2016
    ..of AtHESP in plant lines affects the expression and rhythmicity of the clock core oscillator genes TOC1 and CCA1. This study demonstrates an evolutionary conserved poly(A)-degrading activity in plants and suggests deadenylation ..
  16. pmc Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis
    Dawn H Nagel
    Molecular and Computational Biology Section, University of Southern California, Los Angeles, CA 90089
    Proc Natl Acad Sci U S A 112:E4802-10. 2015
    ..As a key component of the clock, the Myb-like transcription factor CIRCADIAN CLOCK ASSOCIATED1 (CCA1) is able to initiate and set the phase of clock-controlled rhythms and has been shown to regulate gene expression ..
  17. doi Circadian expression profiles of chromatin remodeling factor genes in Arabidopsis
    Hong Gil Lee
    Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University, Jeonju, 561 756, Korea
    J Plant Res 128:187-99. 2015
    ....
  18. pmc LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis circadian oscillator
    QiGuang Xie
    Hebei Key Laboratory of Molecular and Cellular Biology, Key Laboratory of Molecular and Cellular Biology of the Ministry of Education, College of Life Sciences, Hebei Normal University, Hebei Collaboration Innovation Center for Cell Signaling, Shijiazhuang, Hebei 050024, China
    Plant Cell 26:2843-57. 2014
    ..We conclude that LNK1 is a transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1 through recruitment to their promoters via interaction with bona fide DNA binding proteins such as RVE4 and RVE8...
  19. pmc Accurate timekeeping is controlled by a cycling activator in Arabidopsis
    Polly Yingshan Hsu
    Department of Plant Biology, University of California, Davis, Davis, United States
    elife 2:e00473. 2013
    ..Further, our work suggests that the plant clock consists of a highly interconnected, complex regulatory network rather than of coupled morning and evening feedback loops. DOI:http://dx.doi.org/10.7554/eLife.00473.001...
  20. pmc CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses
    Alvina Grace Lai
    Institute of Molecular Biosciences, Massey University, Palmerston North 4442, New Zealand
    Proc Natl Acad Sci U S A 109:17129-34. 2012
    ..Mutations in the core-clock regulator, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), affect the transcriptional regulation of ROS-responsive genes, ROS homeostasis, and tolerance ..
  21. doi Melatonin-induced CBF/DREB1s are essential for diurnal change of disease resistance and CCA1 expression in Arabidopsis
    Haitao Shi
    Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Agriculture, Hainan University, Haikou 570228, China Electronic address
    Plant Physiol Biochem 100:150-5. 2016
    ..Notably, the diurnal changes of endogenous melatonin may regulate corresponding changes of AtCBF/DREB1s expression and their underlying diurnal cycle of plant immunity and AtCCA1.
  22. pmc Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis
    Malia A Dong
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 108:7241-6. 2011
    ..e., Circadian Clock-Associated 1 (CCA1) and Late Elongated Hypocotyl (LHY)...
  23. pmc Direct Repression of Evening Genes by CIRCADIAN CLOCK-ASSOCIATED1 in the Arabidopsis Circadian Clock
    Mari Kamioka
    School of Agriculture, Nagoya University, Furo cho, Chikusa, Nagoya 464 8601, Japan
    Plant Cell 28:696-711. 2016
    ..Here, we demonstrate that direct regulation of PRR5 by CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) determines the repression state of PRR5 in the morning...
  24. doi The clock protein CCA1 and the bZIP transcription factor HY5 physically interact to regulate gene expression in Arabidopsis
    Christos Andronis
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095 1606, USA
    Mol Plant 1:58-67. 2008
    ..of these Arabidopsis genes--Lhcb1*1 and Lhcb1*3--and identified a sequence that binds the clock protein CIRCADIAN CLOCK ASSOCIATED 1 (CCA1)...
  25. ncbi The function of the clock-associated transcriptional regulator CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) in Arabidopsis thaliana
    Masakazu Kawamura
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Biosci Biotechnol Biochem 72:1307-16. 2008
    In the model higher plant Arabidopsis thaliana, the CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) gene plays important circadian clock-associated roles. The CCA1 protein is a member of a small subfamily of single MYB-related transcription factors...
  26. pmc The role of casein kinase II in flowering time regulation has diversified during evolution
    Eri Ogiso
    University of Tsukuba, Tsukuba, Japan 305 8577
    Plant Physiol 152:808-20. 2010
    ..The circadian clock component CIRCADIAN CLOCK ASSOCIATED1 (CCA1) is a CK2 target in Arabidopsis, where it influences photoperiodic flowering...
  27. pmc Suppression of late-flowering and semi-dwarf phenotypes in the Arabidopsis clock mutant lhy-12;cca1-101 by phyB under continuous light
    Kana Miyata
    Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Plant Signal Behav 6:1162-71. 2011
    ..Double mutations in LHY and CCA1 (lhy;cca1) accelerated flowering under short days, mainly by the GI-CO dependent pathway...
  28. ncbi Molecular mechanisms of circadian rhythm in Lotus japonicus and Arabidopsis thaliana are sufficiently compatible to regulate heterologous core clock genes robustly
    Hanayo Ueoka-Nakanishi
    Laboratory of Molecular and Functional Genomics, School of Agriculture, Nagoya University, Nagoya, Japan
    Biosci Biotechnol Biochem 76:2332-4. 2012
    ..thaliana core clock genes CCA1 and PRR5 in heterologous L. japonicus cells and found that the molecular mechanism of circadian rhythm in L...
  29. pmc CCA1 and ELF3 Interact in the control of hypocotyl length and flowering time in Arabidopsis
    Sheen X Lu
    University of California, Department of Molecular, Cell, and Developmental Biology, Los Angeles, California 90095, USA
    Plant Physiol 158:1079-88. 2012
    ..CIRCADIAN CLOCK ASSOCIATED1 (CCA1) is a central clock component, and CCA1 overexpression causes circadian dysfunction, elongated hypocotyls, and late ..
  30. pmc Circadian clock regulates dynamic chromatin modifications associated with Arabidopsis CCA1/LHY and TOC1 transcriptional rhythms
    Hans Hemmes
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, NY 10065 6399, USA
    Plant Cell Physiol 53:2016-29. 2012
    ..The Arabidopsis central oscillator contains three genes encoding core clock components. CIRCADIAN CLOCK ASSOCIATED 1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB EXPRESSION 1 (TOC1) reciprocally repress genes ..
  31. pmc A self-regulatory circuit of CIRCADIAN CLOCK-ASSOCIATED1 underlies the circadian clock regulation of temperature responses in Arabidopsis
    Pil Joon Seo
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    Plant Cell 24:2427-42. 2012
    ..Clock components, including CIRCADIAN CLOCK-ASSOCIATED1 (CCA1), are also associated with cold acclimation...
  32. pmc Rhythmic oscillation of histone acetylation and methylation at the Arabidopsis central clock loci
    Hae Ryong Song
    School of Biological Sciences, Seoul National University, Seoul, 151 747, Korea
    Mol Cells 34:279-87. 2012
    ..In Arabidopsis, LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) transcripts are highly expressed in the morning...
  33. pmc CCA1 alternative splicing as a way of linking the circadian clock to temperature response in Arabidopsis
    Mi Jeong Park
    Department of Chemistry, Seoul National University, Seoul, Korea
    Plant Signal Behav 7:1194-6. 2012
    ..CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) is one of the core clock components in Arabidopsis. Notably, it is also associated with cold acclimation...
  34. ncbi PRR5 (PSEUDO-RESPONSE REGULATOR 5) plays antagonistic roles to CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) in Arabidopsis thaliana
    Toru Fujimori
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Japan
    Biosci Biotechnol Biochem 69:426-30. 2005
    ..In the model higher plant Arabidopsis thaliana, the best candidates for clock components are CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) and LHY (LATE ELONGATED HYPOCOTYL), which are homologous Myb-related transcription ..
  35. pmc TIME FOR COFFEE encodes a nuclear regulator in the Arabidopsis thaliana circadian clock
    Zhaojun Ding
    Department of Plant Developmental Biology, Max Planck Institute for Plant Breeding Research, Cologne D 50829, Germany
    Plant Cell 19:1522-36. 2007
    ..Neither its abundance nor its cellular distribution was found to be clock regulated. We suggest that TIC encodes a nucleus-acting clock regulator working close to the central oscillator...
  36. ncbi Arabidopsis clock-associated pseudo-response regulators PRR9, PRR7 and PRR5 coordinately and positively regulate flowering time through the canonical CONSTANS-dependent photoperiodic pathway
    Norihito Nakamichi
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, 464 8602 Japan
    Plant Cell Physiol 48:822-32. 2007
    ..Then, extensive genetic studies using CIRCADIAN CLOCK-ASSOCIATED1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) double mutants (cca1/lhy) and prr7/prr5 were conducted...
  37. ncbi Genetic linkages between circadian clock-associated components and phytochrome-dependent red light signal transduction in Arabidopsis thaliana
    Shogo Ito
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 48:971-83. 2007
    The current best candidates for Arabidopsis thaliana clock components are CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) and its homolog LHY (LATE ELONGATED HYPOCOTYL)...
  38. ncbi Genetic linkages of the circadian clock-associated genes, TOC1, CCA1 and LHY, in the photoperiodic control of flowering time in Arabidopsis thaliana
    Yusuke Niwa
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 48:925-37. 2007
    ..Nevertheless, the genetic linkages between the major clock-associated TOC1, CCA1 and LHY genes and the canonical CO-FT flowering pathway are less clear...
  39. pmc CIRCADIAN CLOCK ASSOCIATED1 transcript stability and the entrainment of the circadian clock in Arabidopsis
    Esther Yakir
    Department of Plant and Environmental Sciences, Institute for Life Sciences, Hebrew University, Givat Ram, Jerusalem 91904, Israel
    Plant Physiol 145:925-32. 2007
    ..is the light-mediated regulation of expression of one of the oscillator genes, CIRCADIAN CLOCK ASSOCIATED1 (CCA1)...
  40. pmc Systems approach identifies an organic nitrogen-responsive gene network that is regulated by the master clock control gene CCA1
    Rodrigo A Gutierrez
    Department of Biology, New York University, 100 Washington Square East, 1009 Main Building, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 105:4939-44. 2008
    ..integrated network model of molecular interactions, we uncovered a subnetwork regulated by organic N that included CCA1 and target genes involved in N-assimilation...
  41. pmc Circadian rhythms of ethylene emission in Arabidopsis
    Simon C Thain
    Unit Plant Hormone Signaling and Bio Imaging, Department of Molecular Genetics, University of Ghent, Belgium
    Plant Physiol 136:3751-61. 2004
    ..In addition, ethylene production is controlled by the TIMING OF CAB EXPRESSION 1 and CIRCADIAN CLOCK ASSOCIATED 1 genes, which are critical for all circadian rhythms yet tested in Arabidopsis...
  42. pmc Circadian clock proteins LHY and CCA1 regulate SVP protein accumulation to control flowering in Arabidopsis
    Sumire Fujiwara
    Institute of Biological Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Plant Cell 20:2960-71. 2008
    ..we demonstrate that the circadian clock proteins LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) not only repressed the floral transition under short-day and long-day conditions but also accelerated flowering ..
  43. pmc Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock
    On Sun Lau
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Mol Cell 43:703-12. 2011
    ..transcriptional repression activity and physically interacts with two closely related MYB transcription factors, CCA1 and LHY, which are core components of the plant circadian clock...
  44. pmc CIRCADIAN CLOCK ASSOCIATED1 and LATE ELONGATED HYPOCOTYL function synergistically in the circadian clock of Arabidopsis
    Sheen X Lu
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095
    Plant Physiol 150:834-43. 2009
    ..CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) are Myb-related proteins that function in or close to the central oscillator in ..
  45. doi Possible role of early flowering 3 (ELF3) in clock-dependent floral regulation by short vegetative phase (SVP) in Arabidopsis thaliana
    Riichiro Yoshida
    Gene Research Center, University of Tsukuba, Tennodai 1 1 1, Tsukuba, Ibaraki 305 8572, Japan
    New Phytol 182:838-50. 2009
    ..Double mutations in two clock genes, late elongated hypocotyl (LHY) and circadian clock associated 1 (CCA1), accelerated flowering under short days (SDs) but delayed flowering under continuous light (LL) ..
  46. pmc BROTHER OF LUX ARRHYTHMO is a component of the Arabidopsis circadian clock
    Shunhong Dai
    Donald Danforth Plant Science Center, St Louis, Missouri 63132, USA
    Plant Cell 23:961-72. 2011
    ..Arabidopsis circadian clock protein CIRCADIAN CLOCK ASSOCIATED1 (CCA1) binds to the evening element of the BOA promoter and negatively regulates its expression...
  47. doi Timing of plant immune responses by a central circadian regulator
    Wei Wang
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Nature 470:110-4. 2011
    ..downy mildew in Arabidopsis and their regulatory control by the circadian regulator, CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1)...
  48. pmc Circadian regulation of chloroplastic f and m thioredoxins through control of the CCA1 transcription factor
    Juan de Dios Barajas-López
    Estacion Experimental del Zaidin, CSIC, Profesor Albareda 1, 18008 Granada, Spain
    J Exp Bot 62:2039-51. 2011
    ..Binding shift assays indicate that this control probably involves the interaction of the CCA1 transcription factor and an evening element (EE) located in the PsTRX f and PsTRX m1 promoters...
  49. pmc TCP transcription factors link the regulation of genes encoding mitochondrial proteins with the circadian clock in Arabidopsis thaliana
    Estelle Giraud
    Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia
    Plant Cell 22:3921-34. 2010
    ....
  50. pmc The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation
    Patrice A Salome
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Cell 22:3650-61. 2010
    ..are overcompensated, apparently due to hyperactivation of the transcription factors CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY)...
  51. doi The 5'UTR of CCA1 includes an autoregulatory cis element that segregates between light and circadian regulation of CCA1 and LHY
    Alona Ovadia
    Department of Postharvest Science of Fresh Produce, Agricultural Research Organization, The Volcani Center, P O Box 6, 50250, Bet Dagan, Israel
    Plant Mol Biol 72:659-71. 2010
    The transcription factor CCA1 (CIRCADIAN CLOCK ASSOCIATED 1) participates in both light and circadian clock regulation in Arabidopsis. Two sets of transgenic plants in which GFP was fused to the CCA1 promoter with (1...