COP1

Summary

Gene Symbol: COP1
Description: Transducin/WD40 repeat-like superfamily protein
Alias: ARABIDOPSIS THALIANA CONSTITUTIVE PHOTOMORPHOGENIC 1, ATCOP1, CONSTITUTIVE PHOTOMORPHOGENIC 1, DEETIOLATED MUTANT 340, DET340, EMB168, EMBRYO DEFECTIVE 168, FUS1, FUSCA 1, T21L14.11, T21L14_11
Species: thale cress

Top Publications

  1. pmc Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome A in balancing light signaling
    Yusuke Saijo
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mol Cell 31:607-13. 2008
  2. pmc Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis
    Jean Jacques Favory
    Faculty of Biology, Institute of Biology II, University of Freiburg, Freiburg, Germany
    EMBO J 28:591-601. 2009
  3. doi CRY1 inhibits COP1-mediated degradation of BIT1, a MYB transcription factor, to activate blue light-dependent gene expression in Arabidopsis
    Sung Hyun Hong
    Division of Molecular and Life Science, POSTECH, Pohang, 790 784, Republic of Korea
    Plant J 55:361-71. 2008
  4. ncbi The degradation of HFR1, a putative bHLH class transcription factor involved in light signaling, is regulated by phosphorylation and requires COP1
    Paula D Duek
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Curr Biol 14:2296-301. 2004
  5. pmc HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling
    In Cheol Jang
    Laboratory of Plant Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:593-602. 2005
  6. doi Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells
    Remco P Crefcoeur
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, CH 1205 Geneva, Switzerland
    Nat Commun 4:1779. 2013
  7. pmc From The Cover: A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening
    Jian Mao
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Proc Natl Acad Sci U S A 102:12270-5. 2005
  8. pmc Arabidopsis CONSTANS-LIKE3 is a positive regulator of red light signaling and root growth
    Sourav Datta
    Department of Cell and Molecular Biology, Gothenburg University, Sweden
    Plant Cell 18:70-84. 2006
  9. doi COP1 re-accumulates in the nucleus under shade
    Manuel Pacín
    IFEVA, Facultad de Agronomia, Universidad de Buenos Aires and CONICET, 1417, Buenos Aires, Argentina
    Plant J 75:631-41. 2013
  10. pmc CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis
    Attila Oravecz
    Institute of Biology II Botany, University of Freiburg, D 79104 Freiburg, Germany
    Plant Cell 18:1975-90. 2006

Scientific Experts

  • Ute Hoecker
  • Xiping Wang
  • QiGuang Xie
  • Eri Adams
  • Andrea Schrader
  • Xing Wang Deng
  • Xi Huang
  • Roman Ulm
  • Haiyang Wang
  • Jianping Yang
  • Magnus Holm
  • Jigang Li
  • Marc Heijde
  • In Cheol Jang
  • X W Deng
  • Dongqing Xu
  • Eberhard Schafer
  • Yusuke Saijo
  • Haodong Chen
  • Ferenc Nagy
  • Hak Soo Seo
  • Vicente Rubio
  • Nam Hai Chua
  • Hong Li Lian
  • Danmeng Zhu
  • Hong Quan Yang
  • Alexander Maier
  • Sourav Datta
  • Chamari Hettiarachchi
  • Yunping Shen
  • Andrew O'Hara
  • On Sun Lau
  • Gareth I Jenkins
  • Zecheng Zuo
  • Bin Liu
  • Catherine Cloix
  • Aparna Singh
  • Seonghoe Jang
  • Yuki Yanagawa
  • Chitra Subramanian
  • Andras Viczian
  • Jae Hoon Lee
  • Stefan Kircher
  • Kishore C S Panigrahi
  • Yan Chun Zhang
  • Yu Zhang
  • Eva Adam
  • Attila Oravecz
  • Liron Sarid-Krebs
  • Christian Tellgren-Roth
  • Junjie Ling
  • Yan Jiang
  • Fang Lin
  • M T Osterlund
  • Rajnish Khanna
  • Xiaosa Xu
  • Ning Wei
  • Jian Mao
  • Ruohe Yin
  • Xu Zheng
  • Manuel Pacín
  • Ashwin L Ganpudi
  • Remco P Crefcoeur
  • Dimitry Debrieux
  • Enamul Huq
  • Panyu Yang
  • Jun Yi Yang
  • James A Sullivan
  • Xinhao Ouyang
  • Ling Zhu
  • Cornelia Klose
  • Xi Ying Fan
  • Melanie Binkert
  • Xiaolei Liang
  • Sebastian Rolauffs
  • Sascha Laubinger
  • Federico Valverde
  • George Coupland
  • Chentao Lin
  • Hongtao Liu
  • Jhy Gong Wang
  • Huili Yan
  • Gang Li
  • Luca Rizzini
  • Xuanming Liu
  • Balazs Feher
  • Julia Dyachok
  • C S Hardtke
  • Rae Dong Jeong
  • Hathi Ram

Detail Information

Publications90

  1. pmc Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome A in balancing light signaling
    Yusuke Saijo
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mol Cell 31:607-13. 2008
    ..continuous far-red light and is rapidly destabilized upon red light irradiation by E3 ubiquitin ligases, including COP1. Here we provide evidence that the light signaling repressors SPA proteins contribute to COP1-mediated phyA ..
  2. pmc Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis
    Jean Jacques Favory
    Faculty of Biology, Institute of Biology II, University of Freiburg, Freiburg, Germany
    EMBO J 28:591-601. 2009
    ..UV RESPONSE LOCUS 8 (UVR8) and the multifunctional E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) are key regulators of the UV-B response...
  3. doi CRY1 inhibits COP1-mediated degradation of BIT1, a MYB transcription factor, to activate blue light-dependent gene expression in Arabidopsis
    Sung Hyun Hong
    Division of Molecular and Life Science, POSTECH, Pohang, 790 784, Republic of Korea
    Plant J 55:361-71. 2008
    ..In contrast, COP1 binds to BIT1 and mediates its degradation...
  4. ncbi The degradation of HFR1, a putative bHLH class transcription factor involved in light signaling, is regulated by phosphorylation and requires COP1
    Paula D Duek
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Curr Biol 14:2296-301. 2004
    ..Light-regulated protein stability is a major control point of photomorphogenesis. The ubiquitin E3 ligase COP1 (constitutively photomorphogenic 1) regulates the stability of several light-signaling components...
  5. pmc HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling
    In Cheol Jang
    Laboratory of Plant Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:593-602. 2005
    ..The COP1 E3 ligase represses photomorphogenesis in part by targeting transcription activators such as LAF1 and HY5 for ..
  6. doi Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells
    Remco P Crefcoeur
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, CH 1205 Geneva, Switzerland
    Nat Commun 4:1779. 2013
    ..system based on the ultraviolet-B-dependent interaction of the Arabidopsis ultraviolet-B photoreceptor UVR8 with COP1 that can be performed in visible light background...
  7. pmc From The Cover: A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening
    Jian Mao
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Proc Natl Acad Sci U S A 102:12270-5. 2005
    ..Here, we report a previously uncharacterized role for Arabidopsis CRY and COP1 in the regulation of stomatal opening...
  8. pmc Arabidopsis CONSTANS-LIKE3 is a positive regulator of red light signaling and root growth
    Sourav Datta
    Department of Cell and Molecular Biology, Gothenburg University, Sweden
    Plant Cell 18:70-84. 2006
    CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) is an E3 ubiquitin ligase that represses photomorphogenesis in the dark. Therefore, proteins interacting with COP1 could be important regulators of light-dependent development...
  9. doi COP1 re-accumulates in the nucleus under shade
    Manuel Pacín
    IFEVA, Facultad de Agronomia, Universidad de Buenos Aires and CONICET, 1417, Buenos Aires, Argentina
    Plant J 75:631-41. 2013
    ..CONSTITTUTIVE PHOTOMORPHOGENESIS 1 (COP1) is an E3 ligase involved in the ubiquitin labelling of proteins targeted for degradation...
  10. pmc CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis
    Attila Oravecz
    Institute of Biology II Botany, University of Freiburg, D 79104 Freiburg, Germany
    Plant Cell 18:1975-90. 2006
    CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) is a negative regulator of photomorphogenesis in Arabidopsis thaliana. COP1 functions as an E3 ubiquitin ligase, targeting select proteins for proteasomal degradation in plants as well as in mammals...
  11. pmc Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development
    Haodong Chen
    Peking Yale Joint Center of Plant Molecular Genetics and Agrobiotechnology, College of Life Sciences, Peking University, Beijing 100871, China
    Plant Cell 18:1991-2004. 2006
    Repression of photomorphogenesis in Arabidopsis thaliana requires activity of the COP9 signalosome (CSN), CDD, and COP1 complexes, but how these three complexes work in concert to accomplish this important developmental switch has ..
  12. ncbi HY5 is a point of convergence between cryptochrome and cytokinin signalling pathways in Arabidopsis thaliana
    Filip Vandenbussche
    Department of Molecular Genetics, Unit Plant Hormone Signalling and Bio imaging, Ghent University, Ledeganckstraat 35, B 9000 Gent, Belgium
    Plant J 49:428-41. 2007
    ..increase levels of HY5 protein accumulation, suggesting that cytokinins may function by reducing HY5 degradation by COP1 (constitutively photomorphogenic 1)...
  13. pmc Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state
    Marc Heijde
    Department of Botany and Plant Biology, Sciences III, University of Geneva, CH 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 110:1113-8. 2013
    ..configuration, which leads to interaction with the key signaling protein constitutively photomorphogenic 1 (COP1) and induction of UV-B-protective responses...
  14. pmc Arabidopsis FHY3 and HY5 positively mediate induction of COP1 transcription in response to photomorphogenic UV-B light
    Xi Huang
    College of Life Sciences, Beijing Normal University, Beijing 100875, China
    Plant Cell 24:4590-606. 2012
    ..Here, we report that the multifunctional E3 ubiquitin ligase, CONSTITUTIVE PHOTOMORPHOGENESIS1 (COP1), a known key player in UV-B photomorphogenic responses, is also a UV-B-inducible gene...
  15. pmc COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis
    Li Jun Liu
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Plant Cell 20:292-306. 2008
    ..proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase...
  16. pmc Arabidopsis COP1 shapes the temporal pattern of CO accumulation conferring a photoperiodic flowering response
    Seonghoe Jang
    Department of Plant Developmental Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany
    EMBO J 27:1277-88. 2008
    ..We show that mutations in CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), a component of a ubiquitin ligase, cause extreme early flowering under SDs, and that this is ..
  17. pmc Light regulates COP1-mediated degradation of HFR1, a transcription factor essential for light signaling in Arabidopsis
    Jianping Yang
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853, USA
    Plant Cell 17:804-21. 2005
    ..We demonstrate that HFR1 physically interacts with Constitutive Photomorphogenesis 1 (COP1) and that COP1 exhibits ubiquitin ligase activity toward HFR1 in vitro...
  18. pmc In vivo function of tryptophans in the Arabidopsis UV-B photoreceptor UVR8
    Andrew O'Hara
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Bower Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Plant Cell 24:3755-66. 2012
    ..of UVR8 from dimer to monomer, accumulation in the nucleus, and interaction with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1), which functions with UVR8 in UV-B responses...
  19. pmc C-terminal region of the UV-B photoreceptor UVR8 initiates signaling through interaction with the COP1 protein
    Catherine Cloix
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Proc Natl Acad Sci U S A 109:16366-70. 2012
    ..in the nucleus, where it binds to chromatin, and induces interaction of UVR8 with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1), which functions with UVR8 to control photomorphogenic UV-B responses...
  20. pmc LZF1/SALT TOLERANCE HOMOLOG3, an Arabidopsis B-box protein involved in light-dependent development and gene expression, undergoes COP1-mediated ubiquitination
    Sourav Datta
    Department of Cell and Molecular Biology, Gothenburg University, 405 30 Gothenburg, Sweden
    Plant Cell 20:2324-38. 2008
    ..with two key regulators of light signaling, ELONGATED HYPOCOTYL5 (HY5) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1)...
  21. doi Involvement of COP1 in ethylene- and light-regulated hypocotyl elongation
    Xiaolei Liang
    School of Life Sciences, Lanzhou University, Lanzhou, 730000, People s Republic of China
    Planta 236:1791-802. 2012
    ..CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) is an important downstream component of light signaling...
  22. pmc COP1 and ELF3 control circadian function and photoperiodic flowering by regulating GI stability
    Jae Woong Yu
    Department of Plant Science and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151 921, Korea
    Mol Cell 32:617-30. 2008
    ..Blue-light-sensing cryptochromes, the E3 ubiquitin-ligase COP1, and clock-associated proteins ELF3 and GI regulate this process, although the regulatory link between them is ..
  23. doi Regulation of COP1 nuclear localization by the COP9 signalosome via direct interaction with CSN1
    Xiping Wang
    Beijing Normal University, China
    Plant J 58:655-67. 2009
    b>COP1 and COP9 signalosome (CSN) are key regulators of plant light responses and development. Deficiency in either COP1 or CSN causes a constitutive photomorphogenic phenotype...
  24. pmc Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time
    Haodong Chen
    Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Plant Cell 22:108-23. 2010
    CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) possesses E3 ligase activity and promotes degradation of key factors involved in the light regulation of plant development...
  25. pmc Arabidopsis PHYTOCHROME INTERACTING FACTOR proteins promote phytochrome B polyubiquitination by COP1 E3 ligase in the nucleus
    In Cheol Jang
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, New York 10065, USA
    Plant Cell 22:2370-83. 2010
    ..Nuclear phyB degradation is mediated by COP1 E3 ligase, which preferentially interacts with the PhyB N-terminal region (PhyB-N)...
  26. pmc Blue light-dependent interaction of CRY2 with SPA1 regulates COP1 activity and floral initiation in Arabidopsis
    Zecheng Zuo
    College of Life Sciences, Hunan University, Changsha 410082, China
    Curr Biol 21:841-7. 2011
    ..It has been reported that cryptochromes suppress activity of the multifunctional E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) to regulate gene expression in response to blue light...
  27. pmc Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light
    Bin Liu
    Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China
    Genes Dev 25:1029-34. 2011
    Plant photoreceptors mediate light suppression of the E3 ubiquitin ligase COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1) to affect gene expression and photomorphogenesis...
  28. doi Functional interaction of the circadian clock and UV RESISTANCE LOCUS 8-controlled UV-B signaling pathways in Arabidopsis thaliana
    Balazs Feher
    Institute of Plant Biology, Biological Research Centre of the Hungarian Academy of Sciences, H 6726 Szeged, Hungary
    Plant J 67:37-48. 2011
    ..UV RESISTANCE LOCUS 8 (UVR8) and CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) are required, but ELONGATED HYPOCOTYL 5 (HY5) and HY5 HOMOLOG (HYH) are dispensable for this process...
  29. pmc Constitutive photomorphogenesis 1 and multiple photoreceptors control degradation of phytochrome interacting factor 3, a transcription factor required for light signaling in Arabidopsis
    Diana Bauer
    Biologie II Institut für Botanik, University of Freiburg, Freiburg, Germany D 79104
    Plant Cell 16:1433-45. 2004
    ..We demonstrate that accumulation of PIF3 in the nucleus in dark requires constitutive photomorphogenesis 1 (COP1), a negative regulator of photomorphogenesis, and show that red (R) and far-red light (FR) induce rapid degradation ..
  30. ncbi Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development
    L H Ang
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Mol Cell 1:213-22. 1998
    Arabidopsis COP1 acts as a light-inactivable repressor of photomorphogenic development, but its molecular mode of action remains unclear...
  31. pmc Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development
    K U Torii
    Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208104, 165 Prospect Street, OML 301, New Haven, CT 06520 8104, USA
    EMBO J 17:5577-87. 1998
    Arabidopsis COP1 acts as a repressor of photomorphogenesis in darkness, and light stimuli abrogate the repressive ability and nuclear abundance of COP1...
  32. ncbi The role of COP1 in repression of Arabidopsis photomorphogenic development
    M T Osterlund
    Dept of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Trends Cell Biol 9:113-8. 1999
    Photomorphogenic development in Arabidopsis is regulated by the key repressor COP1, which interacts with specific transcription factors in the nucleus to modulate their activities...
  33. ncbi Targeted destabilization of HY5 during light-regulated development of Arabidopsis
    M T Osterlund
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    Nature 405:462-6. 2000
    ..Two key downstream components, COP1 and HY5, act antagonistically in regulating seedling development...
  34. pmc Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localization signal in planta
    M G Stacey
    Department of Botany, The University of Tennessee, Knoxville, Tennessee 37996 1100, USA
    Plant Physiol 124:979-90. 2000
    The Arabidopsis COP1 protein functions as a developmental regulator, in part by repressing photomorphogenesis in darkness...
  35. pmc Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1
    M Holm
    Department of Molecular, Cellular and Developmental Biology, Yale University, OML 354, Yale University, PO Box 20 8104, 165 Prospect Street, New Haven, CT 06520 8104, USA
    EMBO J 20:118-27. 2001
    Arabidopsis COP1 is a photomorphogenesis repressor capable of directly interacting with the photomorphogenesis-promoting factor HY5. This interaction between HY5 and COP1 results in targeted deg radation of HY5 by the 26S proteasome...
  36. pmc Constitutively active UVR8 photoreceptor variant in Arabidopsis
    Marc Heijde
    Department of Botany and Plant Biology, Sciences III, University of Geneva, CH 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 110:20326-31. 2013
    ..results in its instantaneous monomerization followed by interaction with CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1), a major factor in UV-B signaling...
  37. ncbi Direct interaction of Arabidopsis cryptochromes with COP1 in light control development
    H Wang
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 294:154-8. 2001
    Arabidopsis seedling photomorphogenesis involves two antagonistically acting components, COP1 and HY5. COP1 specifically targets HY5 for degradation via the 26S proteasome in the dark through their direct physical interaction...
  38. pmc The signaling mechanism of Arabidopsis CRY1 involves direct interaction with COP1
    H Q Yang
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    Plant Cell 13:2573-87. 2001
    ..The phenotypic properties mediated by CCT are remarkably similar to those of the constitutive photomorphogenic1 (cop1) mutants...
  39. pmc Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B
    Xi Huang
    Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 110:16669-74. 2013
    The evolutionarily conserved constitutive photomorphogenesis 1 (COP1) is a RING and WD40 protein that functions as a substrate receptor of CULLIN4-damaged DNA binding protein 1 (CUL4-DDB1)-based E3 ubiquitin ligases in both plants and ..
  40. ncbi LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1
    Hak Soo Seo
    Laboratory of Plant Molecular Biology, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 423:995-9. 2003
    ..The RING motif protein COP1 is also important because cop1 mutants exhibit constitutive photomorphogenesis in darkness...
  41. ncbi The SPA1-like proteins SPA3 and SPA4 repress photomorphogenesis in the light
    Sascha Laubinger
    Department of Plant Developmental and Molecular Biology, University of Dusseldorf, Geb 26 03 02, D 40225 Dusseldorf, Germany
    Plant J 35:373-85. 2003
    ..further show that SPA3 as well as SPA4 can physically interact with the constitutive repressor of light signaling COP1. Deletion analyses suggest that SPA3 and SPA4, like SPA1, bind to the coiled-coil domain of COP1...
  42. pmc Photoreceptor ubiquitination by COP1 E3 ligase desensitizes phytochrome A signaling
    Hak Soo Seo
    Laboratory of Plant Molecular Biology, Rockefeller University, New York, NY 10021, USA
    Genes Dev 18:617-22. 2004
    ..The phyA PAS domain interacts with the COP1 WD40 domain...
  43. pmc The Arabidopsis repressor of light signaling, COP1, is regulated by nuclear exclusion: mutational analysis by bioluminescence resonance energy transfer
    Chitra Subramanian
    Department of Botany, University of Tennessee, Knoxville, TN 37996 1100, USA
    Proc Natl Acad Sci U S A 101:6798-802. 2004
    ..on protein-protein interactions in live plant cells by using the Arabidopsis Constitutive photomorphogenesis 1 (COP1) protein as a model system...
  44. pmc Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis
    Magnus Holm
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    Genes Dev 16:1247-59. 2002
    Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light...
  45. pmc Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes
    Yuki Yanagawa
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    Genes Dev 18:2172-81. 2004
    COP10 is a ubiquitin-conjugating enzyme variant (UEV), which is thought to act together with COP1, DET1, and the COP9 signalosome (CSN) in Arabidopsis to repress photomorphogenesis...
  46. pmc Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains
    T W McNellis
    Department of Biology, Yale University, New Haven, Connecticut 06520 8104
    Plant Cell 6:487-500. 1994
    The Arabidopsis protein COP1, encoded by the constitutive photomorphogenic locus 1, is an essential regulatory molecule that plays a role in the repression of photomorphogenic development in darkness and in the ability of light-grown ..
  47. ncbi The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis
    U Hoecker
    Institut für Entwicklungs und Molekularbiologie der Pflanzen, University of Dusseldorf, Building 26 03 02, D 40225 Dusseldorf, Germany
    J Biol Chem 276:38173-8. 2001
    ..that shows high sequence similarity to the WD-repeat region of the constitutive repressor of light signaling, COP1. Here, using yeast two-hybrid and in vitro interaction assays, we show that SPA1 strongly and selectively binds to ..
  48. pmc The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity
    Yusuke Saijo
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 17:2642-7. 2003
    Arabidopsis COP1 is a constitutive repressor of photomorphogenesis that interacts with photomorphogenesis-promoting factors such as HY5 to promote their proteasome-mediated degradation...
  49. ncbi Flowering of Arabidopsis cop1 mutants in darkness
    Mayu Nakagawa
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, N10 W8, Sapporo, 060 0810 Japan
    Plant Cell Physiol 45:398-406. 2004
    To elucidate the role of the COP1 gene in flowering, we analyzed flowering of cop1 mutant lines in darkness. When grown in the presence of 1% (w/v) sucrose, the cop1-6 mutant flowered in darkness, but cop1-1 and cop1-4 did not...
  50. pmc The mediator complex subunit PFT1 interferes with COP1 and HY5 in the regulation of Arabidopsis light signaling
    Cornelia Klose
    Albert Ludwigs Universitat Freiburg, Faculty of Biology, Institut für Biologie 2, Botanik, 79104 Freiburg, Germany
    Plant Physiol 160:289-307. 2012
    ..Our data further indicate that PFT1 regulates the floral transition downstream of phyA. The PFT1 missense mutation seems to create a constitutively active transcription factor by mimicking an early step in light signaling...
  51. doi Phosphorylation of CONSTANS and its COP1-dependent degradation during photoperiodic flowering of Arabidopsis
    Liron Sarid-Krebs
    Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, Cologne, D 50829, Germany
    Plant J 84:451-63. 2015
    ..in short days is due to instability of CO, which is efficiently ubiquitinated in the dark by the CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase complex. Here we show that CO is also phosphorylated...
  52. pmc Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a dynamic signaling mechanism
    Hong Li Lian
    Plant Science Institute, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, China
    Genes Dev 25:1023-8. 2011
    ..The signaling mechanism by which CRYs regulate light responses involves their physical interactions with COP1. Here, we report that CRY1 interacts physically with SPA1 in a blue-light-dependent manner...
  53. pmc COP1/SPA ubiquitin ligase complexes repress anthocyanin accumulation under low light and high light conditions
    Alexander Maier
    a Botanical Institute and Cluster of Excellence on Plant Sciences CEPLAS University of Cologne Cologne, Germany
    Plant Signal Behav 10:e970440. 2015
    ..Here, we show that mutations in the key repressor of light signaling, the COP1/SPA complex, cause a strong hyperaccumulation of anthocyanins not only under normal light but also under excess, ..
  54. pmc Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association
    Dongqing Xu
    State Key Laboratory of Protein and Plant Gene Research, Peking Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences and School of Life Sciences, Peking University, Beijing, China
    PLoS Genet 11:e1005747. 2015
    b>CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) functions as an E3 ubiquitin ligase and mediates a variety of developmental processes in Arabidopsis by targeting a number of key regulators for ubiquitination and degradation...
  55. pmc BZS1, a B-box protein, promotes photomorphogenesis downstream of both brassinosteroid and light signaling pathways
    Xi Ying Fan
    Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
    Mol Plant 5:591-600. 2012
    ..of function of BZS1 reduces plant sensitivity to light and partly suppresses the constitutive photomorphogenesis 1 (cop1) mutant in the dark, suggesting a positive role in light response...
  56. pmc COP1 jointly modulates cytoskeletal processes and electrophysiological responses required for stomatal closure
    Rajnish Khanna
    Department of Plant Biology, Carnegie Institution for Science, 260 Panama Street, Stanford, CA 94305, USA
    Mol Plant 7:1441-54. 2014
    ..Here, we investigate how environmental and hormonal signals cause these rearrangements and find that COP1, a RING-finger-type ubiquitin E3 ligase, is required for degradation of tubulin, likely by the 26S proteasome...
  57. pmc PHYTOCHROME INTERACTING FACTOR1 Enhances the E3 Ligase Activity of CONSTITUTIVE PHOTOMORPHOGENIC1 to Synergistically Repress Photomorphogenesis in Arabidopsis
    Xiaosa Xu
    Department of Molecular Biosciences and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712
    Plant Cell 26:1992-2006. 2014
    CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) is a RING/WD40 repeat-containing ubiquitin E3 ligase that is conserved from plants to humans...
  58. pmc The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings
    Dongqing Xu
    Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, State Key Laboratory of Protein and Plant Gene Research, Peking Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China Department of Biological and Environmental Sciences, Gothenburg University, SE 405 30 Gothenburg, Sweden
    Plant Cell 26:1981-1991. 2014
    CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) functions as an E3 ubiquitin ligase in both plants and animals...
  59. pmc MIDGET cooperates with COP1 and SPA1 to repress flowering in Arabidopsis thaliana
    Andrea Schrader
    University of Cologne Botanical Institute III Koeln, Germany
    Plant Signal Behav 8:. 2013
    ..When environmental conditions are unsuitable, both processes are actively repressed by the action of COP1/SPA protein complexes which participate in ubiquitylation and subsequent degradation of transcription factors...
  60. pmc Arabidopsis phytochrome B promotes SPA1 nuclear accumulation to repress photomorphogenesis under far-red light
    Xu Zheng
    Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    Plant Cell 25:115-33. 2013
    ..SUPPRESSOR OF PHYA-105 (SPA1) forms an E3 ubiquitin ligase complex with CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1), which is responsible for the degradation of various photomorphogenesis-promoting factors, resulting in ..
  61. pmc Conditional involvement of constitutive photomorphogenic1 in the degradation of phytochrome A
    Dimitry Debrieux
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Plant Physiol 161:2136-45. 2013
    ..Cullin1 and the ubiquitin E3 ligase constitutive photomorphogenic1 (COP1) have been implicated in this process...
  62. doi MIDGET connects COP1-dependent development with endoreduplication in Arabidopsis thaliana
    Andrea Schrader
    University of Cologne, Botanical Institute III, Zuelpicher Str 47b, 50674, Koeln, Germany
    Plant J 75:67-79. 2013
    In Arabidopsis thaliana, loss of CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) function leads to constitutive photomorphogenesis in the dark associated with inhibition of endoreduplication in the hypocotyl, and a post-germination growth arrest...
  63. pmc Genetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1
    Ashwin L Ganpudi
    Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada R3T 2N2
    G3 (Bethesda) 3:493-503. 2013
    ..a viable partial loss of function allele of DDB1B, ddb1b-2, to examine genetic interactions with DDB1A, DET1 and COP1. Although the ddb1b-2 ddb1a double mutant is lethal, ddb1a ddb1b-2/+ and ddb1b-2 ddb1a/+ heterozygotes exhibit few ..
  64. pmc Arabidopsis COP1 and SPA genes are essential for plant elongation but not for acceleration of flowering time in response to a low red light to far-red light ratio
    Sebastian Rolauffs
    Center of Excellence on Plant Sciences, Botanical Institute, Biocenter, University of Cologne, 50674 Cologne, Germany
    Plant Physiol 160:2015-27. 2012
    ..The repressor of light signaling, CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1), has been shown previously to be essential for the shade-avoidance response in seedlings...
  65. doi A short amino-terminal part of Arabidopsis phytochrome A induces constitutive photomorphogenic response
    Andras Viczian
    Institute of Plant Biology, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari krt 62, H 6726 Szeged, Hungary
    Mol Plant 5:629-41. 2012
    ..We demonstrate that in vitro and in vivo PHYA406 Pfr and Pr bind COP1, a general repressor of photomorphogenesis, and co-localize with it in nuclear bodies...
  66. pmc Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana
    Aparna Singh
    National Institute of Plant Genome Research, Aruna Asaf Ali Marg, 10067 New Delhi, India
    J Biol Chem 287:25995-6009. 2012
    ..Whereas the bZIP proteins, HY5 (elongated hypocotyl 5) and HYH (HY5 homologue), are degraded by COP1-mediated proteasomal pathways, GBF1 is degraded by a proteasomal pathway independent of COP1...
  67. pmc Cip4, a new COP1 target, is a nucleus-localized positive regulator of Arabidopsis photomorphogenesis
    Y Y Yamamoto
    Plant Function Exploration Team, Plant Functional Genomics Research Group, Genomic Sciences Center, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Plant Cell 13:399-411. 2001
    Arabidopsis COP1 acts within the nucleus to repress photomorphogenesis, and its nuclear abundance is negatively regulated by light. Here, we report the identification of a COP1-interactive partner, CIP4...
  68. ncbi The central coiled-coil domain and carboxyl-terminal WD-repeat domain of Arabidopsis SPA1 are responsible for mediating repression of light signaling
    Jianping Yang
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853, USA
    Plant J 47:564-76. 2006
    Arabidopsis constitutive photomorphogenic 1 (COP1) is an E3 ubiquitin ligase that directly binds and targets for degradation a number of photomorphogenesis-promoting transcription factors, including HY5 and HFR1, to desensitize light ..
  69. ncbi Repression of light signaling by Arabidopsis SPA1 involves post-translational regulation of HFR1 protein accumulation
    Jianping Yang
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853, USA
    Plant J 43:131-41. 2005
    ..Arabidopsis COP1 represses light signaling by acting as an E3 ubiquitin ligase in the nucleus, and is responsible for targeted ..
  70. ncbi Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8)
    Christian S Hardtke
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Plant J 30:385-94. 2002
    Arabidopsis COP1 is a negative regulator of photomorphogenesis, which targets HY5, a positive regulator of photomorphogenesis, for degradation via the proteasome pathway in the absence of light...
  71. pmc Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis
    Genki Suzuki
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 16:554-9. 2002
    ..Among them, COP1 and the COP9 signalosome have been hypothesized to fulfill the roles as an ubiquitin ligase (E3) and an essential ..
  72. pmc Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling
    In Cheol Jang
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 21:2100-11. 2007
    ..Polyubiquitinations of LAF1 and HFR1 by the COP1 E3 ligase in vitro are inhibited by LAF1/HFR1 association...
  73. pmc HY5 stability and activity in arabidopsis is regulated by phosphorylation in its COP1 binding domain
    C S Hardtke
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    EMBO J 19:4997-5006. 2000
    Arabidopsis HY5 is a bZIP transcription factor that promotes photomorphogenesis. Previous studies suggested that COP1, a negative regulator of photomorphogenesis, directly interacts with nuclear HY5 and targets it for proteasome-mediated ..
  74. ncbi The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein
    K U Torii
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    J Biol Chem 274:27674-81. 1999
    The constitutive photomorphogenic 1 (COP1) protein of Arabidopsis functions as a molecular switch for the seedling developmental fates: photomorphogenesis under light conditions and skotomorphogenesis in darkness...
  75. ncbi A novel motif mediates the targeting of the Arabidopsis COP1 protein to subnuclear foci
    M G Stacey
    Department of Botany, The University of Tennessee, Knoxville, Tennessee 37996 1100, USA
    J Biol Chem 274:27231-6. 1999
    The constitutive photomorphogenesis 1 (COP1) protein of Arabidopsis thaliana accumulates in discrete subnuclear foci...
  76. pmc Role of a COP1 interactive protein in mediating light-regulated gene expression in arabidopsis
    Y Y Yamamoto
    Department of Molecular, Cellular, and Developmental Biology, Yale University, 165 Prospect Street, New Haven, Connecticut 06520 8104, USA
    Plant Cell 10:1083-94. 1998
    ..An Arabidopsis nuclear protein, CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1), acts to repress photomorphogenesis in the absence of light...
  77. pmc Expression of an N-terminal fragment of COP1 confers a dominant-negative effect on light-regulated seedling development in Arabidopsis
    T W McNellis
    Department of Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    Plant Cell 8:1491-503. 1996
    CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) is an essential regulatory gene that plays a role in light control of seedling development in Arabidopsis...
  78. pmc Arabidopsis COP1 protein specifically interacts in vitro with a cytoskeleton-associated protein, CIP1
    M Matsui
    Department of Biology, Yale University, New Haven, CT 06520 8104, USA
    Proc Natl Acad Sci U S A 92:4239-43. 1995
    Arabidopsis COP1 acts inside the nucleus to suppress photomorphogenic cellular development, and light inactivation of COP1 may involve a specific control of its nuclear activity in hypocotyls and cotyledons, but not in roots, of ..
  79. ncbi A suite of tools and application notes for in vivo protein interaction assays using bioluminescence resonance energy transfer (BRET)
    Chitra Subramanian
    Department of Biochemistry, Cellular and Molecular Biology, The University of Tennessee, Knoxville, TN 37996 0840, USA
    Plant J 48:138-52. 2006
    ..then detected BRET between three pairs of candidate interaction partners: dimerization of the E3 ubiquitin ligase COP1, interaction between COP1 and the B-box protein STH, and interaction between the light regulatory bZip ..
  80. pmc Arabidopsis transcription factor ELONGATED HYPOCOTYL5 plays a role in the feedback regulation of phytochrome A signaling
    Jigang Li
    Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Plant Cell 22:3634-49. 2010
    ..Together, our data show that HY5 plays a role in negative feedback regulation of phyA signaling by attenuating FHY3/FAR1-activated FHY1/FHL expression, providing a mechanism for fine-tuning phyA signaling homeostasis...
  81. pmc An inositol polyphosphate 5-phosphatase functions in PHOTOTROPIN1 signaling in Arabidopis by altering cytosolic Ca2+
    Xu Chen
    Shanghai Institutes for Biological Science University of California Berkeley Center of Molecular Life Sciences, Chinese Academy of Sciences, 20032 Shanghai, China
    Plant Cell 20:353-66. 2008
    ....
  82. doi The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability
    Esther M N Dohmann
    Tubingen University, Center for Plant Molecular Biology, Department of Developmental Genetics, Auf der Morgenstelle 3 5, 72076 Tubingen, Germany
    Development 135:2013-22. 2008
    ..is also apparent in mutants of the NEDD8 conjugation pathway and in mutants of the E3 ligase subunits CULLIN4, COP1 and DET1, which share phenotypes with csn mutants...
  83. pmc Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development
    Danmeng Zhu
    Peking Yale Joint Center of Plant Molecular Genetics and Agrobiotechnology, College of Life Sciences, Peking University, Beijing 100871, China
    Plant Cell 20:2307-23. 2008
    b>COP1 (for CONSTITUTIVELY PHOTOMORPHOGENIC1) and the four partially redundant SPA (for SUPPRESSOR OF PHYA) proteins work in concert to repress photomorphogenesis in Arabidopsis thaliana by targeting key transcription factors and ..
  84. doi GBF1, a transcription factor of blue light signaling in Arabidopsis, is degraded in the dark by a proteasome-mediated pathway independent of COP1 and SPA1
    Chandrashekara Mallappa
    National Institute for Plant Genome Research, Laboratory 101, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Biol Chem 283:35772-82. 2008
    ..the genetic and molecular interrelation of GBF1 with two well characterized negative regulators of light signaling, COP1 and SPA1, in photomorphogenic growth and light-regulated gene expression...
  85. pmc Cryptochromes, phytochromes, and COP1 regulate light-controlled stomatal development in Arabidopsis
    Chun Ying Kang
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Plant Cell 21:2624-41. 2009
    ..b>COP1, a RING motif-containing E3 ubiquitin ligase, acts as a key repressor of photomorphogenesis...
  86. pmc SCAR mediates light-induced root elongation in Arabidopsis through photoreceptors and proteasomes
    Julia Dyachok
    Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Cell 23:3610-26. 2011
    ..SCAR1 degradation in dark-grown wild-type roots by constitutive photomorphogenic 1 (COP1) E3 ligase and 26S proteasome accompanied the loss of longitudinal F-actin and reduced root ..
  87. pmc Nuclear localization and interaction with COP1 are required for STO/BBX24 function during photomorphogenesis
    Huili Yan
    Faculty of Biology, Cell Biology, University of Freiburg, D 79104 Freiburg, Germany
    Plant Physiol 156:1772-82. 2011
    ..signal transduction that localizes to the nucleus of plant cells and interacts with CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) in the yeast (Saccharomyces cerevisiae) two-hybrid system...
  88. pmc FAR-RED INSENSITIVE219 modulates CONSTITUTIVE PHOTOMORPHOGENIC1 activity via physical interaction to regulate hypocotyl elongation in Arabidopsis
    Jhy Gong Wang
    Institute of Plant Biology, College of Life Science, National Taiwan University, Taipei 106, Taiwan
    Plant Physiol 156:631-46. 2011
    ..Previous genetic studies revealed that FIN219 acts as an extragenic suppressor of CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1). However, the molecular mechanism underlying the suppression of COP1 remains unknown...
  89. pmc Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligase
    Rae Dong Jeong
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Proc Natl Acad Sci U S A 107:13538-43. 2010
    ..not directly associate with either CRY2 or PHOT2 but does bind the CRY2-/PHOT2-interacting E3 ubiquitin ligase, COP1. Application of the proteasome inhibitor, MG132, prevents blue-light-dependent degradation of HRT, consequently ..
  90. doi AtBBX21 and COP1 genetically interact in the regulation of shade avoidance
    Carlos D Crocco
    Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura, Facultad de Agronomia, Universidad de Buenos Aires CONICET, Buenos Aires, Argentina
    Plant J 64:551-62. 2010
    ..Mutations in the photomorphogenic repressor COP1 suppress the SAS, but how COP1 modulates these responses is uncertain...