EDS1

Summary

Gene Symbol: EDS1
Description: alpha/beta-Hydrolases superfamily protein
Alias: ATEDS1, EDS1 PROTEIN, enhanced disease susceptibility 1, alpha/beta-Hydrolases superfamily protein
Species: thale cress
Products:     EDS1

Top Publications

  1. Falk A, Feys B, Frost L, Jones J, Daniels M, Parker J. EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Proc Natl Acad Sci U S A. 1999;96:3292-7 pubmed
    ..In Arabidopsis thaliana, EDS1 is indispensable for the function of these R genes...
  2. Wiermer M, Feys B, Parker J. Plant immunity: the EDS1 regulatory node. Curr Opin Plant Biol. 2005;8:383-9 pubmed
    b>ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner, PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal resistance to invasive biotrophic and hemi-biotrophic pathogens...
  3. Feys B, Wiermer M, Bhat R, Moisan L, Medina Escobar N, Neu C, et al. Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity. Plant Cell. 2005;17:2601-13 pubmed
    ..invasive biotrophic pathogens depends on the intracellular defense regulator ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)...
  4. Venugopal S, Jeong R, Mandal M, Zhu S, Chandra Shekara A, Xia Y, et al. Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. PLoS Genet. 2009;5:e1000545 pubmed publisher
    ..Salicylic acid (SA) and its associated proteinaceous signaling components, including enhanced disease susceptibility 1 (EDS1), non-race-specific disease resistance 1 (NDR1), phytoalexin deficient 4 (PAD4), senescence ..
  5. Bhattacharjee S, Halane M, Kim S, Gassmann W. Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators. Science. 2011;334:1405-8 pubmed publisher
    ..We show that Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), a positive regulator of basal resistance and of effector-triggered immunity specifically mediated by Toll-..
  6. Heidrich K, Wirthmueller L, Tasset C, Pouzet C, Deslandes L, Parker J. Arabidopsis EDS1 connects pathogen effector recognition to cell compartment-specific immune responses. Science. 2011;334:1401-4 pubmed publisher
    ..Nucleo-cytoplasmic basal resistance regulator EDS1 (ENHANCED DISEASE SUSCEPTIBILITY1) is indispensible for immunity mediated by TIR (Toll-interleukin-1 receptor)-NB-..
  7. Kim T, Kunz H, Bhattacharjee S, Hauser F, Park J, Engineer C, et al. Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis. Plant Cell. 2012;24:5177-92 pubmed publisher
    ..of early abscisic acid signal transduction via PHYTOALEXIN DEFICIENT4 (PAD4)- and ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)-dependent immune signaling mechanisms...
  8. Mühlenbock P, Szechynska Hebda M, Plaszczyca M, Baudo M, Mateo A, Mullineaux P, et al. Chloroplast signaling and LESION SIMULATING DISEASE1 regulate crosstalk between light acclimation and immunity in Arabidopsis. Plant Cell. 2008;20:2339-56 pubmed publisher
    ..of EEE-induced programmed cell death depends on the plant defense regulators ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) and PHYTOALEXIN DEFICIENT4 (PAD4)...
  9. Zhu S, Jeong R, Venugopal S, Lapchyk L, Navarre D, Kachroo A, et al. SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus. PLoS Pathog. 2011;7:e1002318 pubmed publisher
    b>EDS1, PAD4, and SAG101 are common regulators of plant immunity against many pathogens...
  10. Straus M, Rietz S, Ver Loren van Themaat E, Bartsch M, Parker J. Salicylic acid antagonism of EDS1-driven cell death is important for immune and oxidative stress responses in Arabidopsis. Plant J. 2010;62:628-40 pubmed publisher
    ..Arabidopsis Enhanced Disease Susceptibility1 (EDS1) regulates defense and cell death against biotrophic pathogens and controls cell death propagation in response to ..

Detail Information

Publications38

  1. Falk A, Feys B, Frost L, Jones J, Daniels M, Parker J. EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Proc Natl Acad Sci U S A. 1999;96:3292-7 pubmed
    ..In Arabidopsis thaliana, EDS1 is indispensable for the function of these R genes...
  2. Wiermer M, Feys B, Parker J. Plant immunity: the EDS1 regulatory node. Curr Opin Plant Biol. 2005;8:383-9 pubmed
    b>ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner, PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal resistance to invasive biotrophic and hemi-biotrophic pathogens...
  3. Feys B, Wiermer M, Bhat R, Moisan L, Medina Escobar N, Neu C, et al. Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity. Plant Cell. 2005;17:2601-13 pubmed
    ..invasive biotrophic pathogens depends on the intracellular defense regulator ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)...
  4. Venugopal S, Jeong R, Mandal M, Zhu S, Chandra Shekara A, Xia Y, et al. Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. PLoS Genet. 2009;5:e1000545 pubmed publisher
    ..Salicylic acid (SA) and its associated proteinaceous signaling components, including enhanced disease susceptibility 1 (EDS1), non-race-specific disease resistance 1 (NDR1), phytoalexin deficient 4 (PAD4), senescence ..
  5. Bhattacharjee S, Halane M, Kim S, Gassmann W. Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators. Science. 2011;334:1405-8 pubmed publisher
    ..We show that Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), a positive regulator of basal resistance and of effector-triggered immunity specifically mediated by Toll-..
  6. Heidrich K, Wirthmueller L, Tasset C, Pouzet C, Deslandes L, Parker J. Arabidopsis EDS1 connects pathogen effector recognition to cell compartment-specific immune responses. Science. 2011;334:1401-4 pubmed publisher
    ..Nucleo-cytoplasmic basal resistance regulator EDS1 (ENHANCED DISEASE SUSCEPTIBILITY1) is indispensible for immunity mediated by TIR (Toll-interleukin-1 receptor)-NB-..
  7. Kim T, Kunz H, Bhattacharjee S, Hauser F, Park J, Engineer C, et al. Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis. Plant Cell. 2012;24:5177-92 pubmed publisher
    ..of early abscisic acid signal transduction via PHYTOALEXIN DEFICIENT4 (PAD4)- and ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)-dependent immune signaling mechanisms...
  8. Mühlenbock P, Szechynska Hebda M, Plaszczyca M, Baudo M, Mateo A, Mullineaux P, et al. Chloroplast signaling and LESION SIMULATING DISEASE1 regulate crosstalk between light acclimation and immunity in Arabidopsis. Plant Cell. 2008;20:2339-56 pubmed publisher
    ..of EEE-induced programmed cell death depends on the plant defense regulators ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) and PHYTOALEXIN DEFICIENT4 (PAD4)...
  9. Zhu S, Jeong R, Venugopal S, Lapchyk L, Navarre D, Kachroo A, et al. SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus. PLoS Pathog. 2011;7:e1002318 pubmed publisher
    b>EDS1, PAD4, and SAG101 are common regulators of plant immunity against many pathogens...
  10. Straus M, Rietz S, Ver Loren van Themaat E, Bartsch M, Parker J. Salicylic acid antagonism of EDS1-driven cell death is important for immune and oxidative stress responses in Arabidopsis. Plant J. 2010;62:628-40 pubmed publisher
    ..Arabidopsis Enhanced Disease Susceptibility1 (EDS1) regulates defense and cell death against biotrophic pathogens and controls cell death propagation in response to ..
  11. Bartsch M, Gobbato E, Bednarek P, Debey S, Schultze J, Bautor J, et al. Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7. Plant Cell. 2006;18:1038-51 pubmed
    Arabidopsis thaliana ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) controls defense activation and programmed cell death conditioned by intracellular Toll-related immune receptors that recognize specific pathogen effectors...
  12. Wagner S, Stuttmann J, Rietz S, Guerois R, Brunstein E, Bautor J, et al. Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity. Cell Host Microbe. 2013;14:619-30 pubmed publisher
    ..pathogens encounter a postinfection basal resistance layer controlled by the lipase-like protein enhanced disease susceptibility 1 (EDS1) and its sequence-related interaction partners, senescence-associated gene 101 (SAG101) and ..
  13. Mishina T, Zeier J. Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis. Plant J. 2007;50:500-13 pubmed
    ..Our data indicate that PAMPs significantly contribute to SAR initiation in Arabidopsis and that tissue necroses at inoculation sites are dispensable for SAR activation. ..
  14. Ochsenbein C, Przybyla D, Danon A, Landgraf F, Gobel C, Imboden A, et al. The role of EDS1 (enhanced disease susceptibility) during singlet oxygen-mediated stress responses of Arabidopsis. Plant J. 2006;47:445-56 pubmed
    ..One of the genes that is rapidly upregulated is EDS1 (enhanced disease susceptibility). The EDS1 protein has been shown to be required for the resistance to biotrophic pathogens and the accumulation of salicylic acid ..
  15. Rietz S, Stamm A, Malonek S, Wagner S, Becker D, Medina Escobar N, et al. Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity. New Phytol. 2011;191:107-19 pubmed publisher
    Enhanced Disease Susceptibility1 (EDS1) is an important regulator of plant basal and receptor-triggered immunity...
  16. Wituszynska W, Slesak I, Vanderauwera S, Szechynska Hebda M, Kornas A, Van Der Kelen K, et al. Lesion simulating disease1, enhanced disease susceptibility1, and phytoalexin deficient4 conditionally regulate cellular signaling homeostasis, photosynthesis, water use efficiency, and seed yield in Arabidopsis. Plant Physiol. 2013;161:1795-805 pubmed publisher
    ..In this study, we examined the role of lesion simulating disease1 (LSD1), enhanced disease susceptibility1 (EDS1), and phytoalexin deficient4 (PAD4) in the regulation of photosynthesis, water use efficiency, reactive oxygen ..
  17. Feys B, Moisan L, Newman M, Parker J. Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4. EMBO J. 2001;20:5400-11 pubmed
    The Arabidopsis EDS1 and PAD4 genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance...
  18. Cheng Y, Germain H, Wiermer M, Bi D, Xu F, García A, et al. Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis. Plant Cell. 2009;21:2503-16 pubmed publisher
    ..Our analysis shows that nuclear accumulation of snc1 and the defense signaling components Enhanced Disease Susceptibility 1 and Nonexpresser of PR genes 1 is significantly reduced in mos7-1 plants, while nuclear retention of ..
  19. Schön M, Töller A, Diezel C, Roth C, Westphal L, Wiermer M, et al. Analyses of wrky18 wrky40 plants reveal critical roles of SA/EDS1 signaling and indole-glucosinolate biosynthesis for Golovinomyces orontii resistance and a loss-of resistance towards Pseudomonas syringae pv. tomato AvrRPS4. Mol Plant Microbe Interact. 2013;26:758-67 pubmed publisher
    ..imbalance in salicylic acid (SA) and jasmonic acid (JA) signaling, altered ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) expression, and accumulation of the phytoalexin camalexin...
  20. Wang Y, Zhang Y, Wang Z, Zhang X, Yang S. A missense mutation in CHS1, a TIR-NB protein, induces chilling sensitivity in Arabidopsis. Plant J. 2013;75:553-65 pubmed publisher
    ..The chilling sensitivity of chs1 was fully rescued by pad4 and eds1, but not by ndr1. The overexpression of the TIR and NB domains can suppress the chs1-conferred phenotypes...
  21. Mühlenbock P, Plaszczyca M, Plaszczyca M, Mellerowicz E, Karpinski S. Lysigenous aerenchyma formation in Arabidopsis is controlled by LESION SIMULATING DISEASE1. Plant Cell. 2007;19:3819-30 pubmed
    ..depends on the plant defense regulators LESION SIMULATING DISEASE1 (LSD1), ENHANCED DISEASE SUSCEPIBILITY1 (EDS1), and PHYTOALEXIN DEFICIENT4 (PAD4) that operate upstream of ethylene and reactive oxygen species production...
  22. Carstens M, McCrindle T, Adams N, Diener A, Guzha D, Murray S, et al. Increased resistance to biotrophic pathogens in the Arabidopsis constitutive induced resistance 1 mutant is EDS1 and PAD4-dependent and modulated by environmental temperature. PLoS ONE. 2014;9:e109853 pubmed publisher
    ..with two key components of the SA-signalling branch of the defence network, ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) and PHYTOALEXIN DEFICIENT4 (PAD4)...
  23. Kohorn B, Kohorn S, Saba N, Martinez V. Requirement for pectin methyl esterase and preference for fragmented over native pectins for wall-associated kinase-activated, EDS1/PAD4-dependent stress response in Arabidopsis. J Biol Chem. 2014;289:18978-86 pubmed publisher
    ..allele of WAK2 constitutively activates the stress response, and we show here that the effect is dependent upon EDS1 and PAD4, transcriptional activators involved in the pathogen response...
  24. Cui H, Gobbato E, Kracher B, Qiu J, Bautor J, Parker J. A core function of EDS1 with PAD4 is to protect the salicylic acid defense sector in Arabidopsis immunity. New Phytol. 2017;213:1802-1817 pubmed publisher
    ..SA accumulation is promoted by Enhanced Disease Susceptibility1 with its co-regulator Phytoalexin Deficient4 (EDS1/PAD4). Current models position EDS1/PAD4 upstream of SA but their functional relationship remains unclear...
  25. Wittek F, Hoffmann T, Kanawati B, Bichlmeier M, Knappe C, Wenig M, et al. Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid. J Exp Bot. 2014;65:5919-31 pubmed publisher
    ..disease resistance that depends on salicylic acid and its upstream regulator ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)...
  26. Brodersen P, Petersen M, Bjørn Nielsen H, Zhu S, Newman M, Shokat K, et al. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. Plant J. 2006;47:532-46 pubmed
    ..SA-repressing and ET/JA-(co)activating functions depend on MPK4 kinase activity and involve the defense regulators EDS1 and PAD4, as mutations in these genes suppress de-repression of the SA pathway and suppress the block of the ET/JA ..
  27. Lee M, Jelenska J, Greenberg J. Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1. Plant J. 2008;54:452-65 pubmed publisher
    ..Several known genes important for SA production or signaling are also partially (EDS1, NIM1/NPR1, ACD6 and ALD1) or strongly (PAD4) required for the robust resistance induced by HopW1-1, suggesting a ..
  28. Wang J, Shine M, Gao Q, Navarre D, Jiang W, Liu C, et al. Enhanced Disease Susceptibility1 Mediates Pathogen Resistance and Virulence Function of a Bacterial Effector in Soybean. Plant Physiol. 2014;165:1269-1284 pubmed
    Enhanced disease susceptibility1 (EDS1) and phytoalexin deficient4 (PAD4) are well-known regulators of both basal and resistance (R) protein-mediated plant defense...
  29. Gao M, Wang X, Wang D, Xu F, Ding X, Zhang Z, et al. Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host Microbe. 2009;6:34-44 pubmed publisher
    ..Our data suggest that BIR1 negatively regulates multiple plant resistance signaling pathways, one of which is the SOBIR1-dependent pathway identified here. ..
  30. Gao F, Shu X, Ali M, Howard S, Li N, Winterhagen P, et al. A functional EDS1 ortholog is differentially regulated in powdery mildew resistant and susceptible grapevines and complements an Arabidopsis eds1 mutant. Planta. 2010;231:1037-47 pubmed publisher
    ..Arabidopsis eds1-1 mutant showed that the EDS1-like gene with highest predicted amino acid sequence similarity to AtEDS1 from either grapevine varieties is a functional ortholog of AtEDS1...
  31. Pegadaraju V, Louis J, Singh V, Reese J, Bautor J, Feys B, et al. Phloem-based resistance to green peach aphid is controlled by Arabidopsis PHYTOALEXIN DEFICIENT4 without its signaling partner ENHANCED DISEASE SUSCEPTIBILITY1. Plant J. 2007;52:332-41 pubmed
    ..In Arabidopsis defense against pathogens, all known PAD4 functions require its signaling and stabilizing partner EDS1 (ENHANCED DISEASE SUSCEPTIBILITY1)...
  32. Szechynska Hebda M, Czarnocka W, Hebda M, Bernacki M, Karpiński S. PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties. Plant Cell Rep. 2016;35:527-39 pubmed publisher
    ..of proteins encoded by PHYTOALEXIN DEFICIENT 4 (PAD4), LESION SIMULATING DISEASE 1 (LSD1) and ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) genes to explain their role in drought tolerance and biomass production in two different ..
  33. Wang X, Sager R, Cui W, Zhang C, Lu H, Lee J. Salicylic acid regulates Plasmodesmata closure during innate immune responses in Arabidopsis. Plant Cell. 2013;25:2315-29 pubmed publisher
    ..We discuss a model wherein the SA signaling pathway and plasmodesmata-mediated cell-to-cell communication converge under an intricate regulatory loop...
  34. Gao F, Dai R, Pike S, Qiu W, Gassmann W. Functions of EDS1-like and PAD4 genes in grapevine defenses against powdery mildew. Plant Mol Biol. 2014;86:381-93 pubmed publisher
    ..examined the functions of defense genes associated with the salicylic acid (SA) pathway, including ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), EDS1-LIKE 2 (EDL2), EDL5 and PHYTOALEXIN DEFICIENT 4 (PAD4) of two grapevine species, Vitis ..
  35. Wirthmueller L, Zhang Y, Jones J, Parker J. Nuclear accumulation of the Arabidopsis immune receptor RPS4 is necessary for triggering EDS1-dependent defense. Curr Biol. 2007;17:2023-9 pubmed
    ..conserved feature of TIR-NB-LRR receptors is their recruitment of the nucleocytoplasmic basal-defense regulator EDS1 in resistance to diverse pathogens...
  36. Moreau M, Degrave A, Vedel R, Bitton F, Patrit O, Renou J, et al. EDS1 contributes to nonhost resistance of Arabidopsis thaliana against Erwinia amylovora. Mol Plant Microbe Interact. 2012;25:421-30 pubmed publisher
    ..amylovora infection are related to defense and signaling. Analysis of mutants affected in NDR1 and EDS1, two main components of the defense-gene activation observed, revealed that E...
  37. Wagner S, Rietz S, Parker J, Niefind K. Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:245-8 pubmed publisher
    In plants, the nucleocytoplasmic protein EDS1 (Enhanced disease susceptibility1) is an important regulator of innate immunity, coordinating host-cell defence and cell-death programs in response to pathogen attack...
  38. Wituszynska W, Szechynska Hebda M, Sobczak M, Rusaczonek A, Kozłowska Makulska A, Witoń D, et al. Lesion simulating disease 1 and enhanced disease susceptibility 1 differentially regulate UV-C-induced photooxidative stress signalling and programmed cell death in Arabidopsis thaliana. Plant Cell Environ. 2015;38:315-30 pubmed publisher
    ..In the present study, we show that lesion simulating disease 1 (LSD1) and enhanced disease susceptibility 1 (EDS1) are antagonistic regulators of UV-C-induced programmed cell death (PCD) in Arabidopsis ..