FCA

Summary

Gene Symbol: FCA
Description: flowering time control protein FCA
Alias: BETA, DELTA AND GAMMA, DL4180C, FCAALL.331, FLOWERING TIME CONTROL PROTEIN FCA ALPHA
Species: thale cress

Top Publications

  1. doi FCA does not bind abscisic acid
    Joanna M Risk
    Biochemistry Department, University of Otago, Dunedin 9054, New Zealand
    Nature 456:E5-6. 2008
  2. ncbi FCA, a gene controlling flowering time in Arabidopsis, encodes a protein containing RNA-binding domains
    R Macknight
    Department of Molecular Genetics, John Innes Centre, Norwich Research Park, Colney, United Kingdom
    Cell 89:737-45. 1997
  3. pmc Analysis of flowering time control in Arabidopsis by comparison of double and triple mutants
    P H Reeves
    John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Plant Physiol 126:1085-91. 2001
  4. doi FCA mediates thermal adaptation of stem growth by attenuating auxin action in Arabidopsis
    Hyo Jun Lee
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    Nat Commun 5:5473. 2014
  5. doi The Arabidopsis thaliana RNA-binding protein FCA regulates thermotolerance by modulating the detoxification of reactive oxygen species
    Sangmin Lee
    Department of Chemistry, Seoul National University, Seoul, 151 742, Korea
    New Phytol 205:555-69. 2015
  6. ncbi The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC
    Fuquan Liu
    Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Mol Cell 28:398-407. 2007
  7. pmc Arabidopsis RNA-binding protein FCA regulates microRNA172 processing in thermosensory flowering
    Jae Hoon Jung
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 287:16007-16. 2012
  8. ncbi Widespread role for the flowering-time regulators FCA and FPA in RNA-mediated chromatin silencing
    Isabel Bäurle
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Science 318:109-12. 2007
  9. pmc RNA 3' processing functions of Arabidopsis FCA and FPA limit intergenic transcription
    Cagla Sonmez
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 108:8508-13. 2011
  10. pmc Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA
    Gordon G Simpson
    Department of Cell and Developmental Biology, John Ines Centre, Norfolk NR4 7UH, United Kingdom
    Plant Cell 22:3764-77. 2010

Scientific Experts

  • M Koornneef
  • Isabel Bäurle
  • Catherine L Day
  • Matteo Sugliani
  • Cagla Sonmez
  • Jae Hoon Jung
  • Gordon G Simpson
  • Sangmin Lee
  • Hyo Jun Lee
  • Chung Mo Park
  • Caroline Dean
  • Tomasz J Sarnowski
  • Victor Quesada
  • Fuquan Liu
  • Szymon Swiezewski
  • Richard C Macknight
  • Joanna M Risk
  • Yun Hee Jang
  • Paul P Dijkwel
  • S Marquardt
  • Fawzi A Razem
  • Ian R Henderson
  • Szymon Kaczanowski
  • Katarzyna Pawlikowska
  • Andrzej Jerzmanowski
  • Lucas Cortés Llorca
  • Sang Gyu Kim
  • Ian T Baldwin
  • C Dean
  • Pil Joon Seo
  • Ji Hoon Ahn
  • P H Reeves
  • Rebecca E Laurie
  • Peter A Stockwell
  • Jeong Kook Kim
  • W J Soppe
  • Jeong Hwan Lee
  • Pedro Crevillen
  • Robert D Hill
  • Ashraf El-Kereamy
  • J Hadfield
  • Suzanne R Abrams
  • P K Boss
  • Sinead Drea
  • Jan Jasik
  • Yong Li
  • Csaba Koncz
  • Gabino Rios
  • Piotr Koźbiał
  • Aleksandra Kwiatkowska
  • Marta Koźbiał
  • R Macknight
  • Ian Henderson
  • G Coupland
  • L Bentsink
  • R Schmidt
  • L Westphal
  • C Lister
  • S Sherson
  • I Bancroft
  • G Murphy
  • K Love
  • C Cobbett
  • T Page

Detail Information

Publications19

  1. doi FCA does not bind abscisic acid
    Joanna M Risk
    Biochemistry Department, University of Otago, Dunedin 9054, New Zealand
    Nature 456:E5-6. 2008
    The RNA-binding protein FCA promotes flowering in Arabidopsis. Razem et al. reported that FCA is also a receptor for the phytohormone abscisic acid (ABA)...
  2. ncbi FCA, a gene controlling flowering time in Arabidopsis, encodes a protein containing RNA-binding domains
    R Macknight
    Department of Molecular Genetics, John Innes Centre, Norwich Research Park, Colney, United Kingdom
    Cell 89:737-45. 1997
    A strong promoter of the transition to flowering in Arabidopsis is encoded by FCA. FCA has been cloned and shown to encode a protein containing two RNA-binding domains and a WW protein interaction domain...
  3. pmc Analysis of flowering time control in Arabidopsis by comparison of double and triple mutants
    P H Reeves
    John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Plant Physiol 126:1085-91. 2001
    ..These pathways are represented by the genes CO, FCA, and GA1, which act in the long-day, autonomous, and gibberellin pathways, respectively...
  4. doi FCA mediates thermal adaptation of stem growth by attenuating auxin action in Arabidopsis
    Hyo Jun Lee
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    Nat Commun 5:5473. 2014
    ..Here we demonstrate that the RNA-binding protein FCA attenuates PIF4 activity by inducing its dissociation from the YUC8 promoter at high temperature...
  5. doi The Arabidopsis thaliana RNA-binding protein FCA regulates thermotolerance by modulating the detoxification of reactive oxygen species
    Sangmin Lee
    Department of Chemistry, Seoul National University, Seoul, 151 742, Korea
    New Phytol 205:555-69. 2015
    ..Here, we demonstrate that the RNA-binding protein FCA, a key component of flowering pathways in Arabidopsis thaliana, is required for the acquisition of thermotolerance...
  6. ncbi The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC
    Fuquan Liu
    Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Mol Cell 28:398-407. 2007
    A repressor of the transition to flowering in Arabidopsis is the MADS box protein FLOWERING LOCUS C (FLC). FCA, an RNA-binding protein, and FY, a homolog of the yeast RNA 3' processing factor Pfs2p, downregulate FLC expression and ..
  7. pmc Arabidopsis RNA-binding protein FCA regulates microRNA172 processing in thermosensory flowering
    Jae Hoon Jung
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 287:16007-16. 2012
    ..Here, we show that Arabidopsis RNA-binding protein FCA promotes the processing of primary microRNA172 transcripts (pri-miR172) in response to changes in ambient ..
  8. ncbi Widespread role for the flowering-time regulators FCA and FPA in RNA-mediated chromatin silencing
    Isabel Bäurle
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Science 318:109-12. 2007
    The RRM-domain proteins FCA and FPA have previously been characterized as flowering-time regulators in Arabidopsis. We show that they are required for RNA-mediated chromatin silencing of a range of loci in the genome...
  9. pmc RNA 3' processing functions of Arabidopsis FCA and FPA limit intergenic transcription
    Cagla Sonmez
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 108:8508-13. 2011
    The RNA-binding proteins FCA and FPA were identified based on their repression of the flowering time regulator FLC but have since been shown to have widespread roles in the Arabidopsis thaliana genome...
  10. pmc Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA
    Gordon G Simpson
    Department of Cell and Developmental Biology, John Ines Centre, Norfolk NR4 7UH, United Kingdom
    Plant Cell 22:3764-77. 2010
    The RNA binding protein FCA regulates the floral transition and is required for silencing RNAs corresponding to specific noncoding sequences in the Arabidopsis thaliana genome...
  11. pmc The conserved splicing factor SUA controls alternative splicing of the developmental regulator ABI3 in Arabidopsis
    Matteo Sugliani
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany
    Plant Cell 22:1936-46. 2010
    ..We detected two ABI3 transcripts, ABI3-alpha and ABI3-beta, which encode full-length and truncated proteins, respectively...
  12. doi Abscisic acid does not disrupt either the Arabidopsis FCA-FY interaction or its rice counterpart in vitro
    Yun Hee Jang
    Plant Signaling Network Research Center, School of Life Sciences and Biotechnology, Korea University, Seoul, 136 701, Korea
    Plant Cell Physiol 49:1898-901. 2008
    We examined the effect of (+)-ABA on the in vitro interaction of rice FCA and FY homologs, OsFCA and OsFY. From this analysis, we found no disruption of the OsFCA-OsFY complexes by ABA treatment...
  13. ncbi Additional targets of the Arabidopsis autonomous pathway members, FCA and FY
    S Marquardt
    Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    J Exp Bot 57:3379-86. 2006
    ..One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK...
  14. pmc SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play distinct roles during Arabidopsis development
    Tomasz J Sarnowski
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02 106 Warsaw, Poland
    Plant Cell 17:2454-72. 2005
    ..and ATSWI3B form homodimers and heterodimers and interact with BSH/SNF5, ATSWI3C, and the flowering regulator FCA, ATSWI3D can only bind ATSWI3B in yeast two-hybrid assays...
  15. ncbi An allelic series reveals essential roles for FY in plant development in addition to flowering-time control
    Ian R Henderson
    Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, UK
    Development 132:3597-607. 2005
    ..Within this pathway FCA is a plant-specific, nuclear RNA-binding protein, which interacts with FY, a highly conserved eukaryotic ..
  16. ncbi FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition
    Gordon G Simpson
    Department of Cell and Developmental Biology, John Innes Centre, Norwich, United Kingdom
    Cell 113:777-87. 2003
    The nuclear RNA binding protein, FCA, promotes Arabidopsis reproductive development. FCA contains a WW protein interaction domain that is essential for FCA function. We have identified FY as a protein partner for this domain...
  17. pmc AtSWI3B, an Arabidopsis homolog of SWI3, a core subunit of yeast Swi/Snf chromatin remodeling complex, interacts with FCA, a regulator of flowering time
    Tomasz J Sarnowski
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw University, Pawinskiego 5A, 02 106 Warsaw, Poland
    Nucleic Acids Res 30:3412-21. 2002
    ..using recombinant protein, confirmed by direct yeast two-hybrid analyses, indicate that AtSWI3B interacts with FCA, a regulator of flowering time in Arabidopsis...
  18. ncbi The early-flowering mutant efs is involved in the autonomous promotion pathway of Arabidopsis thaliana
    W J Soppe
    Laboratory of Genetics, Wageningen University, Dreijenlaan 2, Wageningen, The Netherlands
    Development 126:4763-70. 1999
    ..Double mutant analysis with several late-flowering mutants from the autonomous promotion (fca and fve) and the photoperiod promotion (co, fwa and gi) pathways of flowering showed that efs reduces the flowering ..
  19. ncbi The RNA-binding protein FCA is an abscisic acid receptor
    Fawzi A Razem
    Department of Plant Science, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Nature 439:290-4. 2006
    ..Here we show that FCA, an RNA-binding protein involved in flowering, binds ABA with high affinity in an interaction that is ..