LHY

Summary

Gene Symbol: LHY
Description: Homeodomain-like superfamily protein
Alias: LATE ELONGATED HYPOCOTYL, LATE ELONGATED HYPOCOTYL 1, LHY1, T25K16.6, T25K16_6
Species: thale cress

Top Publications

  1. ncbi LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis
    Tsuyoshi Mizoguchi
    John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Dev Cell 2:629-41. 2002
  2. ncbi ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY
    Elise A Kikis
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant J 44:300-13. 2005
  3. pmc A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock
    Jose L Pruneda-Paz
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Science 323:1481-5. 2009
  4. doi Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis
    Gang Li
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nat Cell Biol 13:616-22. 2011
  5. pmc A complex genetic interaction between Arabidopsis thaliana TOC1 and CCA1/LHY in driving the circadian clock and in output regulation
    Zhaojun Ding
    Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Genetics 176:1501-10. 2007
  6. pmc LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis circadian oscillator
    QiGuang Xie
    Hebei Key Laboratory of Molecular and Cellular Biology, Key Laboratory of Molecular and Cellular Biology of the Ministry of Education, College of Life Sciences, Hebei Normal University, Hebei Collaboration Innovation Center for Cell Signaling, Shijiazhuang, Hebei 050024, China
    Plant Cell 26:2843-57. 2014
  7. pmc Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis
    Malia A Dong
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 108:7241-6. 2011
  8. pmc A self-regulatory circuit of CIRCADIAN CLOCK-ASSOCIATED1 underlies the circadian clock regulation of temperature responses in Arabidopsis
    Pil Joon Seo
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    Plant Cell 24:2427-42. 2012
  9. pmc Suppression of late-flowering and semi-dwarf phenotypes in the Arabidopsis clock mutant lhy-12;cca1-101 by phyB under continuous light
    Kana Miyata
    Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Plant Signal Behav 6:1162-71. 2011
  10. pmc The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
    Alexandra Pokhilko
    School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Syst Biol 8:574. 2012

Scientific Experts

  • Tsuyoshi Mizoguchi
  • Kanae Niinuma
  • Hae Ryong Song
  • Kana Miyata
  • Sumire Fujiwara
  • Shogo Ito
  • Norihito Nakamichi
  • Zhaojun Ding
  • George Coupland
  • On Sun Lau
  • Gang Li
  • Riichiro Yoshida
  • Yusuke Niwa
  • Takafumi Yamashino
  • Takeshi Mizuno
  • QiGuang Xie
  • Isabelle A Carre
  • Pil Joon Seo
  • Hans Hemmes
  • Alexandra Pokhilko
  • C Robertson McClung
  • Xing Wang Deng
  • In Cheol Jang
  • Malia A Dong
  • Patrice A Salome
  • Bong Soo Park
  • Estelle Giraud
  • Andrew J Millar
  • Sheen X Lu
  • Jose L Pruneda-Paz
  • Mark Spensley
  • Kounosuke Hayashi
  • Mayu Nakagawa
  • Atsushi Oda
  • Yusuke Tomozoe
  • Masanori Kita
  • Seth J Davis
  • Elise A Kikis
  • Louisa Wright
  • Yue Li
  • Xiaodong Xu
  • Liya Zhi
  • Lingbao Wang
  • Hongya Xing
  • Peng Wang
  • Chenguang Zhang
  • Xian Liu
  • Zhiliang Yue
  • Li Yuan
  • Chunsheng Zhao
  • Nam Hai Chua
  • Yoo Sun Noh
  • Kieron D Edwards
  • Megan M Southern
  • Chung Mo Park
  • Aurora Piñas Fernández
  • Minyoung Lee
  • Karen J Halliday
  • Sang Gyu Kim
  • Mi Jeong Park
  • Ian T Baldwin
  • Rossana Henriques
  • Mi Hye Lim
  • Sanghee Kim
  • Xi Huang
  • Jae Hoon Lee
  • Jianmin Wan
  • Xiang Yuan Wan
  • Xinhao Ouyang
  • Jigang Li
  • Paul F Devlin
  • Michael F Thomashow
  • Martín Calviño
  • Rongcheng Lin
  • Eva M Farré
  • Yibo Teng
  • Jean Benoit Charron
  • Hamad Siddiqui
  • Haiyang Wang
  • Mingqiu Dai
  • Atsushi Oda Oda
  • Haruna Sugiyama
  • Hee Jeong Eo
  • A Harvey Millar
  • Chris Carrie
  • James Whelan
  • Hong Gu Kang
  • Hak Soo Seo
  • Detlef Weigel
  • Owen Duncan

Detail Information

Publications29

  1. ncbi LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis
    Tsuyoshi Mizoguchi
    John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Dev Cell 2:629-41. 2002
    ..b>LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved...
  2. ncbi ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY
    Elise A Kikis
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant J 44:300-13. 2005
    ..that a negative transcriptional feedback loop formed by the genes CIRCADIAN CLOCK ASSOCIATED (CCA1), LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB (TOC1) constitutes the core of the central oscillator of the circadian clock in ..
  3. pmc A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock
    Jose L Pruneda-Paz
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Science 323:1481-5. 2009
    ..CHE is a clock component partially redundant with LHY in the repression of CCA1...
  4. doi Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis
    Gang Li
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nat Cell Biol 13:616-22. 2011
    ..of the central oscillator, and activate its expression during the day, whereas the circadian-controlled CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn through physical interactions with these ..
  5. pmc A complex genetic interaction between Arabidopsis thaliana TOC1 and CCA1/LHY in driving the circadian clock and in output regulation
    Zhaojun Ding
    Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Genetics 176:1501-10. 2007
    It has been proposed that CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) together with TIMING OF CAB EXPRESSION 1 (TOC1) make up the central oscillator of the Arabidopsis thaliana circadian clock...
  6. pmc LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis circadian oscillator
    QiGuang Xie
    Hebei Key Laboratory of Molecular and Cellular Biology, Key Laboratory of Molecular and Cellular Biology of the Ministry of Education, College of Life Sciences, Hebei Normal University, Hebei Collaboration Innovation Center for Cell Signaling, Shijiazhuang, Hebei 050024, China
    Plant Cell 26:2843-57. 2014
    ..We conclude that LNK1 is a transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1 through recruitment to their promoters via interaction with bona fide DNA binding proteins such as RVE4 and RVE8...
  7. pmc Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis
    Malia A Dong
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 108:7241-6. 2011
    ..e., Circadian Clock-Associated 1 (CCA1) and Late Elongated Hypocotyl (LHY)...
  8. pmc A self-regulatory circuit of CIRCADIAN CLOCK-ASSOCIATED1 underlies the circadian clock regulation of temperature responses in Arabidopsis
    Pil Joon Seo
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    Plant Cell 24:2427-42. 2012
    ..CCA1β interferes with the formation of CCA1α-CCA1α and LATE ELONGATED HYPOCOTYL (LHY)-LHY homodimers, as well as CCA1α-LHY heterodimers, by forming nonfunctional heterodimers with ..
  9. pmc Suppression of late-flowering and semi-dwarf phenotypes in the Arabidopsis clock mutant lhy-12;cca1-101 by phyB under continuous light
    Kana Miyata
    Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Plant Signal Behav 6:1162-71. 2011
    ..Double mutations in LHY and CCA1 (lhy;cca1) accelerated flowering under short days, mainly by the GI-CO dependent pathway...
  10. pmc The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
    Alexandra Pokhilko
    School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Syst Biol 8:574. 2012
    ..Our computational analysis suggests that TOC1 is a repressor of the morning genes Late Elongated Hypocotyl and Circadian Clock Associated1 rather than an activator as first conceived...
  11. pmc Rhythmic oscillation of histone acetylation and methylation at the Arabidopsis central clock loci
    Hae Ryong Song
    School of Biological Sciences, Seoul National University, Seoul, 151 747, Korea
    Mol Cells 34:279-87. 2012
    Circadian clock genes are regulated by a transcriptional-translational feedback loop. In Arabidopsis, LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) transcripts are highly expressed in the morning...
  12. pmc Circadian clock regulates dynamic chromatin modifications associated with Arabidopsis CCA1/LHY and TOC1 transcriptional rhythms
    Hans Hemmes
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, NY 10065 6399, USA
    Plant Cell Physiol 53:2016-29. 2012
    ..CIRCADIAN CLOCK ASSOCIATED 1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB EXPRESSION 1 (TOC1) reciprocally repress genes encoding each other and are ..
  13. pmc Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock
    On Sun Lau
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Mol Cell 43:703-12. 2011
    ..repression activity and physically interacts with two closely related MYB transcription factors, CCA1 and LHY, which are core components of the plant circadian clock...
  14. doi Possible role of early flowering 3 (ELF3) in clock-dependent floral regulation by short vegetative phase (SVP) in Arabidopsis thaliana
    Riichiro Yoshida
    Gene Research Center, University of Tsukuba, Tennodai 1 1 1, Tsukuba, Ibaraki 305 8572, Japan
    New Phytol 182:838-50. 2009
    ..Double mutations in two clock genes, late elongated hypocotyl (LHY) and circadian clock associated 1 (CCA1), accelerated flowering under short days (SDs) but delayed ..
  15. pmc TCP transcription factors link the regulation of genes encoding mitochondrial proteins with the circadian clock in Arabidopsis thaliana
    Estelle Giraud
    Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia
    Plant Cell 22:3921-34. 2010
    ....
  16. pmc The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation
    Patrice A Salome
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Cell 22:3650-61. 2010
    ..apparently due to hyperactivation of the transcription factors CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY)...
  17. doi Ubiquitination of LHY by SINAT5 regulates flowering time and is inhibited by DET1
    Bong Soo Park
    Department of Plant Science, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151 921, Republic of Korea
    Biochem Biophys Res Commun 398:242-6. 2010
    ..ligase SINAT5, an Arabidopsis homologue of the Drosophila SINA RING-finger protein, interacts directly with LHY, a component of the circadian oscillator, and DET1, a negative regulator of light-regulated gene expression...
  18. pmc Evolutionarily conserved regulatory motifs in the promoter of the Arabidopsis clock gene LATE ELONGATED HYPOCOTYL
    Mark Spensley
    Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    Plant Cell 21:2606-23. 2009
    The transcriptional regulation of the LATE ELONGATED HYPOCOTYL (LHY) gene is key to the structure of the circadian oscillator, integrating information from multiple regulatory pathways...
  19. pmc CIRCADIAN CLOCK ASSOCIATED1 and LATE ELONGATED HYPOCOTYL function synergistically in the circadian clock of Arabidopsis
    Sheen X Lu
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095
    Plant Physiol 150:834-43. 2009
    ..CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) are Myb-related proteins that function in or close to the central oscillator in Arabidopsis (..
  20. pmc Circadian clock proteins LHY and CCA1 regulate SVP protein accumulation to control flowering in Arabidopsis
    Sumire Fujiwara
    Institute of Biological Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Plant Cell 20:2960-71. 2008
    ..Here, we demonstrate that the circadian clock proteins LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) not only repressed the floral transition under short-day and ..
  21. ncbi Genetic linkages of the circadian clock-associated genes, TOC1, CCA1 and LHY, in the photoperiodic control of flowering time in Arabidopsis thaliana
    Yusuke Niwa
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 48:925-37. 2007
    ..Nevertheless, the genetic linkages between the major clock-associated TOC1, CCA1 and LHY genes and the canonical CO-FT flowering pathway are less clear...
  22. ncbi Genetic linkages between circadian clock-associated components and phytochrome-dependent red light signal transduction in Arabidopsis thaliana
    Shogo Ito
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 48:971-83. 2007
    ..for Arabidopsis thaliana clock components are CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) and its homolog LHY (LATE ELONGATED HYPOCOTYL)...
  23. ncbi Arabidopsis clock-associated pseudo-response regulators PRR9, PRR7 and PRR5 coordinately and positively regulate flowering time through the canonical CONSTANS-dependent photoperiodic pathway
    Norihito Nakamichi
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, 464 8602 Japan
    Plant Cell Physiol 48:822-32. 2007
    ..Then, extensive genetic studies using CIRCADIAN CLOCK-ASSOCIATED1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) double mutants (cca1/lhy) and prr7/prr5 were conducted...
  24. pmc TIME FOR COFFEE encodes a nuclear regulator in the Arabidopsis thaliana circadian clock
    Zhaojun Ding
    Department of Plant Developmental Biology, Max Planck Institute for Plant Breeding Research, Cologne D 50829, Germany
    Plant Cell 19:1522-36. 2007
    ..With regard to morning-acting genes, we unexpectedly found that TIC has a closer relationship with LATE ELONGATED HYPOCOTYL (LHY) than with CIRCADIAN CLOCK ASSOCIATED1, as tic has a specific LHY expression level defect...
  25. pmc Distinct roles of GIGANTEA in promoting flowering and regulating circadian rhythms in Arabidopsis
    Tsuyoshi Mizoguchi
    Institute of Biological Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Plant Cell 17:2255-70. 2005
    ..We studied the relationship between the roles of GI in flowering and the circadian clock using late elongated hypocotyl circadian clock associated1 double mutants, which are impaired in circadian clock function, plants ..
  26. ncbi DET1 regulates the proteasomal degradation of LHY, a component of the Arabidopsis circadian clock
    Hae Ryong Song
    Dartmouth College, Hanover, New Hampshire 03755, USA
    Plant Mol Biol 57:761-71. 2005
    ..interaction between DE-ETIOLATED 1 (DET1), a negative regulator of light-regulated gene expression, and LATE ELONGATED HYPOCOTYL (LHY), one of the core components of the circadian oscillator...
  27. pmc The protein kinase CK2 is involved in regulation of circadian rhythms in Arabidopsis
    S Sugano
    Department of Molecular Biology, University of California, Los Angeles, CA 90095 1606, USA
    Proc Natl Acad Sci U S A 96:12362-6. 1999
    ..The circadian clock-associated 1 (CCA1) and the late elongated hypocotyl (LHY) proteins have been shown to be closely associated with clock function in Arabidopsis thaliana...
  28. ncbi The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering
    R Schaffer
    John Innes Centre, Norwich, United Kingdom
    Cell 93:1219-29. 1998
    The dominant late elongated hypocotyl (lhy) mutation of Arabidopsis disrupted circadian clock regulation of gene expression and leaf movements and caused flowering to occur independently of photoperiod...