PFT1

Summary

Gene Symbol: PFT1
Description: phytochrome and flowering time regulatory protein (PFT1)
Alias: F2J7.4, F2J7_4, MED25, PHYTOCHROME AND FLOWERING TIME 1, mediator 25
Species: thale cress

Top Publications

  1. pmc Acceleration of flowering during shade avoidance in Arabidopsis alters the balance between FLOWERING LOCUS C-mediated repression and photoperiodic induction of flowering
    Amanda C Wollenberg
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Plant Physiol 148:1681-94. 2008
  2. ncbi Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit
    Stefan Bäckström
    Department of Medical Biochemistry and Biophysics, KBC, Umea University, SE 901 87 Umea, Sweden
    Mol Cell 26:717-29. 2007
  3. ncbi Regulation of flowering time by light quality
    Pablo D Cerdán
    Howard Hughes Medical Institute and Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 423:881-5. 2003
  4. pmc The mediator complex subunit PFT1 is a key regulator of jasmonate-dependent defense in Arabidopsis
    Brendan N Kidd
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland 4067, Australia
    Plant Cell 21:2237-52. 2009
  5. pmc The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development
    Nils Elfving
    Department of Medical Biochemistry and Biophysics, Umea Plant Science Center, Umea University, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 108:8245-50. 2011
  6. pmc Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes
    Jeanette Blomberg
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Nucleic Acids Res 40:5938-50. 2012
  7. pmc The Mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana
    Mathilde Séguéla-Arnaud
    Cell and Developmental Biology Department, John Innes Centre, Colney Lane, Norwich, NR4 7UH, UK
    BMC Plant Biol 15:215. 2015
  8. pmc Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling
    Feng Zhang
    Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Nature 525:269-73. 2015
  9. pmc CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis
    Yingfang Zhu
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907
    Plant Cell 26:4149-70. 2014
  10. doi VP16 fusion induces the multiple-knockout phenotype of redundant transcriptional repressors partly by Med25-independent mechanisms in Arabidopsis
    Sumire Fujiwara
    Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan Electronic address
    FEBS Lett 588:3665-72. 2014

Scientific Experts

  • Sumire Fujiwara
  • Kalaipandian Sundaravelpandian
  • Jeanette Blomberg
  • Sabrina Iñigo
  • Pablo D Cerdán
  • Stefan Bjorklund
  • Ximena Aguilar
  • Yan Yang
  • Kristoffer Brannstrom
  • Bin Ou
  • Brendan N Kidd
  • Nils Elfving
  • Feng Zhang
  • Mathilde Séguéla-Arnaud
  • Yingfang Zhu
  • Anna Koprivova
  • Pauline Rival
  • Li Zhang
  • Anders Olofsson
  • Wolfgang Schmidt
  • Li Jia Qu
  • Volkan Cevik
  • Rong Chen
  • Cornelia Klose
  • Ran Xu
  • John M Manners
  • Peer M Schenk
  • Kemal Kazan
  • Barbara Strasser
  • Gunnar Wingsle
  • Amanda C Wollenberg
  • Joanne Chory
  • Stefan Bäckström
  • Xiaojun Kang
  • Sheng Yang He
  • Xiu Fang Xin
  • Marcos Castellanos Uribe
  • Patrick R Griffin
  • Caroline Smith
  • X Edward Zhou
  • Harry Fischl
  • H Eric Xu
  • Mingguo Zhou
  • Vinh Q Lam
  • Sean May
  • Jian Chen
  • Neil McKenzie
  • Jian Yao
  • Michael W Bevan
  • Karsten Melcher
  • Jiyuan Ke
  • Joseph Brunzelle
  • Jian Kang Zhu
  • Alexander Calderwood
  • Hongya Gu
  • Jacob Bale
  • Dae Jin Yun
  • Stanislav Kopriva
  • JURGEN SCHLEUCHER
  • Wen Si
  • Soledad F Undurraga
  • Jinzhe Zhang
  • Tesfaye Mengiste
  • Pengcheng Wang
  • Maximilian O Press
  • Christine Queitsch
  • Bok Rye Lee
  • Fuyou Fu
  • Craig M Schluttenhoffer
  • Genji Qin
  • Sang Yeol Lee
  • Tanya Grancharova
  • Jyothi Thimmapuram
  • Nulu Chandrika
  • Yi Hsiu Tsai
  • Nulu Naga Prafulla Chandrika
  • Qingzhe Zhai
  • Linn Rautio
  • Lin Li
  • Claire Hill
  • Jiaqiang Sun
  • Hongmei Li
  • Katherine J Denby
  • Claudia Buche
  • Thomas Kretsch
  • Peijun Zhang
  • Mariano J Alvarez
  • Andrea Califano
  • Hongling Jiang
  • Chuanyou Li

Detail Information

Publications24

  1. pmc Acceleration of flowering during shade avoidance in Arabidopsis alters the balance between FLOWERING LOCUS C-mediated repression and photoperiodic induction of flowering
    Amanda C Wollenberg
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Plant Physiol 148:1681-94. 2008
    ..Finally, our analysis of the contribution of PHYTOCHROME AND FLOWERING TIME1 (PFT1) to shade-mediated rapid flowering has led us to suggest a new model for the involvement of PFT1 in light signaling.
  2. ncbi Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit
    Stefan Bäckström
    Department of Medical Biochemistry and Biophysics, KBC, Umea University, SE 901 87 Umea, Sweden
    Mol Cell 26:717-29. 2007
    ..Most notably, we identify the A. thaliana proteins STRUWWELPETER (SWP) and PHYTOCHROME AND FLOWERING TIME 1 (PFT1) as the Med14 and Med25 subunits, respectively...
  3. ncbi Regulation of flowering time by light quality
    Pablo D Cerdán
    Howard Hughes Medical Institute and Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 423:881-5. 2003
    ..Here we identify PFT1 (PHYTOCHROME AND FLOWERING TIME 1), a nuclear protein that acts in a phyB pathway and induces flowering in response to suboptimal light ..
  4. pmc The mediator complex subunit PFT1 is a key regulator of jasmonate-dependent defense in Arabidopsis
    Brendan N Kidd
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland 4067, Australia
    Plant Cell 21:2237-52. 2009
    ..We report that the PHYTOCHROME AND FLOWERING TIME1 (PFT1) gene, which encodes the MEDIATOR25 subunit of Mediator, is required for jasmonate-dependent defense gene ..
  5. pmc The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development
    Nils Elfving
    Department of Medical Biochemistry and Biophysics, Umea Plant Science Center, Umea University, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 108:8245-50. 2011
    ..We here show that a linear 130-amino-acids-long sequence in the Med25 subunit of the Arabidopsis thaliana Mediator is a common target for the drought response element binding protein ..
  6. pmc Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes
    Jeanette Blomberg
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Nucleic Acids Res 40:5938-50. 2012
    ..By using purified transcription factor Dreb2a, mediator subunit Med25 from Arabidopsis thaliana, and a combination of biochemical and biophysical methods, we show that binding of ..
  7. pmc The Mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana
    Mathilde Séguéla-Arnaud
    Cell and Developmental Biology Department, John Innes Centre, Colney Lane, Norwich, NR4 7UH, UK
    BMC Plant Biol 15:215. 2015
    ..To balance rigidity and extensibility, the composition and integrity of cell wall components need to be tightly regulated, for example during cell elongation...
  8. pmc Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling
    Feng Zhang
    Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Nature 525:269-73. 2015
    ..In this position, the Jas helix competitively inhibits MYC3 interaction with the MED25 subunit of the transcriptional Mediator complex...
  9. pmc CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis
    Yingfang Zhu
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907
    Plant Cell 26:4149-70. 2014
    ..2 and its interaction with MEDIATOR COMPLEX SUBUNIT25 (MED25) implicate CDK8 in jasmonate-mediated defense...
  10. doi VP16 fusion induces the multiple-knockout phenotype of redundant transcriptional repressors partly by Med25-independent mechanisms in Arabidopsis
    Sumire Fujiwara
    Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan Electronic address
    FEBS Lett 588:3665-72. 2014
    ..Loss-of-function of transcriptional coactivator Mediator25 did not affect VP16 activity despite their in vivo interaction, suggesting the existence of other key mechanism(s) in plants. ..
  11. pmc The conserved PFT1 tandem repeat is crucial for proper flowering in Arabidopsis thaliana
    Pauline Rival
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195
    Genetics 198:747-54. 2014
    ..One such STR occurs in the Arabidopsis thaliana gene PFT1 (MED25), where it encodes an interrupted polyglutamine tract...
  12. pmc Interaction studies of the human and Arabidopsis thaliana Med25-ACID proteins with the herpes simplex virus VP16- and plant-specific Dreb2a transcription factors
    Ximena Aguilar
    Department of Chemistry, Umea University, Umea, Sweden
    PLoS ONE 9:e98575. 2014
    ..The Arabidopsis thaliana Med25 (aMed25) ACtivation Interaction Domain (ACID) interacts with the Dreb2a activator which is involved in plant ..
  13. doi Do PFT1 and HY5 interact in regulation of sulfate assimilation by light in Arabidopsis?
    Anna Koprivova
    Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    FEBS Lett 588:1116-21. 2014
    ..Here we show evidence that PHYTOCHROME AND FLOWERING TIME 1 (PFT1) may be another component of the sulfate assimilation regulatory circuit...
  14. doi The Arabidopsis Mediator subunit MED16 regulates iron homeostasis by associating with EIN3/EIL1 through subunit MED25
    Yan Yang
    State Key Laboratory of Protein and Plant Gene Research, Peking Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing, 100871, China
    Plant J 77:838-51. 2014
    ..We demonstrated that YID1/MED16 interacted with another subunit, MED25. MED25 played an important role in regulation of iron homeostasis by interacting with EIN3 and EIL1, two ..
  15. pmc PFT1-controlled ROS balance is critical for multiple stages of root hair development in Arabidopsis
    Kalaipandian Sundaravelpandian
    Institute of Plant and Microbial Biology Academia Sinica Taipei, Taiwan Molecular and Biological Agricultural Sciences Taiwan International Graduate Program National Chung Hsing University Academia Sinica Taipei, Taiwan Graduate Institute of Biotechnology National Chung Hsing University Taichung, Taiwan
    Plant Signal Behav 8:e24066. 2013
    ..Mutations in the Mediator subunit MED25/PFT1 result in compromised root hair development, due to altered expression of a suite of H₂O₂-producing class ..
  16. doi PFT1, the MED25 subunit of the plant Mediator complex, promotes flowering through CONSTANS dependent and independent mechanisms in Arabidopsis
    Sabrina Iñigo
    Fundacion Instituto Leloir, IIBBA CONICET, Buenos Aires, Argentina
    Plant J 69:601-12. 2012
    ..Other phytochromes like phyD and phyE seem to have redundant roles with phyB. PFT1, the MED25 subunit of the plant Mediator complex, has been proposed to act in the light-quality pathway that regulates ..
  17. doi PFT1, a transcriptional Mediator complex subunit, controls root hair differentiation through reactive oxygen species (ROS) distribution in Arabidopsis
    Kalaipandian Sundaravelpandian
    Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan
    New Phytol 197:151-61. 2013
    ..Genetic evidence indicates that the Mediator subunits PFT1/MED25 and MED8 are critical for root hair differentiation, but act via separate mechanisms...
  18. pmc Proteasome-mediated turnover of Arabidopsis MED25 is coupled to the activation of FLOWERING LOCUS T transcription
    Sabrina Iñigo
    Fundacion Instituto Leloir, IIBBA Consejo Nacional de Investigaciones Científicas y Técnicas, C1405BWE Buenos Aires, Argentina
    Plant Physiol 160:1662-73. 2012
    ..Here, we show that, in Arabidopsis (Arabidopsis thaliana), PHYTOCHROME AND FLOWERING TIME1 (PFT1), the MEDIATOR25 (MED25) subunit of the plant Mediator complex, is degraded by the proteasome and that proteasome-mediated PFT1 turnover ..
  19. pmc MEDIATOR25 acts as an integrative hub for the regulation of jasmonate-responsive gene expression in Arabidopsis
    Volkan Cevik
    School of Life Sciences, University of Warwick, Wellesbourne, Warwick CV35 9EF, United Kingdom
    Plant Physiol 160:541-55. 2012
    The PHYTOCHROME AND FLOWERING TIME1 gene encoding the MEDIATOR25 (MED25) subunit of the eukaryotic Mediator complex is a positive regulator of jasmonate (JA)-responsive gene expression in Arabidopsis (Arabidopsis thaliana)...
  20. pmc The Arabidopsis mediator subunit MED25 differentially regulates jasmonate and abscisic acid signaling through interacting with the MYC2 and ABI5 transcription factors
    Rong Chen
    State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research Beijing, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Cell 24:2898-916. 2012
    ..Here, we report the action mechanisms of the MEDIATOR25 (MED25) subunit of the Arabidopsis thaliana Mediator in regulating jasmonate- and abscisic acid (ABA)-triggered gene ..
  21. pmc The mediator complex subunit PFT1 interferes with COP1 and HY5 in the regulation of Arabidopsis light signaling
    Cornelia Klose
    Albert Ludwigs Universitat Freiburg, Faculty of Biology, Institut für Biologie 2, Botanik, 79104 Freiburg, Germany
    Plant Physiol 160:289-307. 2012
    ..The dominant eid3 mutant carries a missense mutation in a conserved domain of PHYTOCHROME AND FLOWERING TIME1 (PFT1), an important component of the plant mediator coactivator complex, which links promoter-bound transcriptional ..
  22. doi Control of final organ size by Mediator complex subunit 25 in Arabidopsis thaliana
    Ran Xu
    State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Development 138:4545-54. 2011
    ..The eod8-1 mutation was identified, using a map-based cloning approach, in Mediator complex subunit 25 (MED25; also known as PFT1), which is involved in the transcriptional regulation of gene expression...
  23. doi A high-throughput screening system for Arabidopsis transcription factors and its application to Med25-dependent transcriptional regulation
    Bin Ou
    National Laboratory for Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, People s Republic of China
    Mol Plant 4:546-55. 2011
    ..We used this system to identify eight TFs that interact with a Mediator subunit, Med25, a key regulator in JA signaling...
  24. ncbi HYPERSENSITIVE TO RED AND BLUE 1 and its C-terminal regulatory function control FLOWERING LOCUS T expression
    Xiaojun Kang
    Department of Plant Biology, University of Minnesota, St Paul, MN 55108, USA
    Plant J 52:937-48. 2007
    ..Overexpression of HRB1 did not affect the expression of the central clock oscillators, TOC1 and CCA1. HRB1 therefore represents a signaling step that regulates FT expression downstream of red and blue light perception...