TOC1

Summary

Gene Symbol: TOC1
Description: CCT motif -containing response regulator protein
Alias: APRR1, AtTOC1, MFB13.13, MFB13_13, PRR1, PSEUDO-RESPONSE REGULATOR 1, TIMING OF CAB EXPRESSION 1
Species: thale cress

Top Publications

  1. ncbi Genetic linkages between circadian clock-associated components and phytochrome-dependent red light signal transduction in Arabidopsis thaliana
    Shogo Ito
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 48:971-83. 2007
  2. ncbi ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY
    Elise A Kikis
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant J 44:300-13. 2005
  3. doi Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins
    Sumire Fujiwara
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:23073-83. 2008
  4. pmc CUL1 regulates TOC1 protein stability in the Arabidopsis circadian clock
    Frank Harmon
    United States Department of Agriculture Agricultural Research Service, Plant Gene Expression Center, Albany, CA 94710, USA
    Plant J 55:568-79. 2008
  5. pmc PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock
    Alessia Para
    Department of Biochemistry, Scripps Research Institute, La Jolla, California 92037, USA
    Plant Cell 19:3462-73. 2007
  6. ncbi ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology Plant Biotechnology Center, Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, Ohio 43210, USA
    Nature 449:356-60. 2007
  7. pmc TOC1 functions as a molecular switch connecting the circadian clock with plant responses to drought
    Tommaso Legnaioli
    Department of Plant Molecular Genetics, Centre for Research in Agricultural Genomics CRAG, CSIC IRTA UAB, Barcelona, Spain
    EMBO J 28:3745-57. 2009
  8. pmc F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression
    Antoine Baudry
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Plant Cell 22:606-22. 2010
  9. pmc GIGANTEA acts in blue light signaling and has biochemically separable roles in circadian clock and flowering time regulation
    Ellen L Martin-Tryon
    Section of Plant Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Plant Physiol 143:473-86. 2007
  10. pmc Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE
    Eva Kevei
    Institute of Plant Biology, Biological Research Centre of the Hungarian Academy of Sciences, Szeged
    Plant Physiol 140:933-45. 2006

Scientific Experts

  • Shogo Ito
  • Takafumi Yamashino
  • Frank Harmon
  • David E Somers
  • Jose L Pruneda-Paz
  • Steve A Kay
  • Andrew J Millar
  • Paloma Mas
  • Benoit Farinas
  • Sumire Fujiwara
  • Zhaojun Ding
  • Woe Yeon Kim
  • Lei Wang
  • Takeshi Mizuno
  • Alessia Para
  • Judit Soy
  • Costas Delis
  • Seth J Davis
  • QiGuang Xie
  • Kanae Niinuma
  • Polly Yingshan Hsu
  • Alexandra Pokhilko
  • Hans Hemmes
  • W Huang
  • Joshua M Gendron
  • Hae Ryong Song
  • Nam Hai Chua
  • Rossana Henriques
  • C Robertson McClung
  • Mikael Johansson
  • Matthew A Jones
  • Peter H Quail
  • Antoine Baudry
  • Stacey L Harmer
  • Tommaso Legnaioli
  • Megan M Southern
  • Takato Imaizumi
  • Péter Gyula
  • Maria E Eriksson
  • Anthony Hall
  • Akinori Matsushika
  • Seiya Makino
  • Linqu Han
  • Sung Suk Suh
  • Ellen L Martin-Tryon
  • Elaine M Tobin
  • Yusuke Niwa
  • P Mas
  • Eva Kevei
  • Elise A Kikis
  • Masahiro Yasuhara
  • Simon C Thain
  • Toru Fujimori
  • Elena Monte
  • Daniela Tsikou
  • Kalliope K Papadopoulou
  • Guiomar Martín
  • Pablo Leivar
  • Nikolaos A A Balatsos
  • Georgios Stravodimos
  • Maria Sentandreu
  • Afrodite Krokida
  • Rafailia A A Beta
  • Céline Diaz
  • Bassem Al-Sady
  • Nahuel Gonzalez-Schain
  • Anastasia Tomatsidou
  • Julietta Moustaka
  • Demetres D Leonidas
  • Maria Tsioumpekou
  • Lingbao Wang
  • Masaya Kojima
  • Zhiliang Yue
  • Chenguang Zhang
  • Peng Wang
  • Xiaodong Xu
  • Li Yuan
  • Hongya Xing
  • Yue Li
  • Xian Liu
  • Liya Zhi
  • Chunsheng Zhao
  • Upendra K Devisetty
  • J L Riechmann
  • A J Millar
  • P Pérez-García
  • Andrew M Gross
  • Kieron D Edwards
  • Yoo Sun Noh
  • Aurora Piñas Fernández

Detail Information

Publications42

  1. ncbi Genetic linkages between circadian clock-associated components and phytochrome-dependent red light signal transduction in Arabidopsis thaliana
    Shogo Ito
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 48:971-83. 2007
    ..The originally described member of PRRs is TOC1 (or PRR1) (TIMING OF CAB EXPRESSION 1). Interestingly, seedlings of A. thaliana carrying a certain lesion (i.e...
  2. ncbi ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY
    Elise A Kikis
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant J 44:300-13. 2005
    ..loop formed by the genes CIRCADIAN CLOCK ASSOCIATED (CCA1), LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB (TOC1) constitutes the core of the central oscillator of the circadian clock in Arabidopsis...
  3. doi Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins
    Sumire Fujiwara
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:23073-83. 2008
    ..Peak expression of TOC1 (timing of cab expression 1)/PRR1, PRR3, PRR5, PRR7, and PRR9 are each phased differently over the course of the day and loss of any ..
  4. pmc CUL1 regulates TOC1 protein stability in the Arabidopsis circadian clock
    Frank Harmon
    United States Department of Agriculture Agricultural Research Service, Plant Gene Expression Center, Albany, CA 94710, USA
    Plant J 55:568-79. 2008
    ..In Arabidopsis thaliana, establishment of the circadian period relies on targeted degradation of TIMING OF CAB EXPRESSION 1 (TOC1) by the 26S proteasome...
  5. pmc PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock
    Alessia Para
    Department of Biochemistry, Scripps Research Institute, La Jolla, California 92037, USA
    Plant Cell 19:3462-73. 2007
    ..The founding member of the family, TIMING OF CAB EXPRESSION1 (TOC1), is an essential component of the transcriptional network that constitutes the core mechanism of the circadian ..
  6. ncbi ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology Plant Biotechnology Center, Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, Ohio 43210, USA
    Nature 449:356-60. 2007
    ..normal circadian period by controlling the proteasome-dependent degradation of a central clock protein, TIMING OF CAB EXPRESSION 1 (TOC1)...
  7. pmc TOC1 functions as a molecular switch connecting the circadian clock with plant responses to drought
    Tommaso Legnaioli
    Department of Plant Molecular Genetics, Centre for Research in Agricultural Genomics CRAG, CSIC IRTA UAB, Barcelona, Spain
    EMBO J 28:3745-57. 2009
    ..A key clock component (TOC1, timing of CAB expression 1) binds to the promoter of the ABA-related gene (ABAR/CHLH/GUN5) and controls its circadian expression...
  8. pmc F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression
    Antoine Baudry
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Plant Cell 22:606-22. 2010
    ..In addition, FKF1 and LKP2 also interacted with TIMING OF CAB EXPRESSION1 (TOC1) and PSEUDO-RESPONSE REGULATOR5 (PRR5), and both proteins were further stabilized in ztl fkf1 and ztl fkf1 lkp2 ..
  9. pmc GIGANTEA acts in blue light signaling and has biochemically separable roles in circadian clock and flowering time regulation
    Ellen L Martin-Tryon
    Section of Plant Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Plant Physiol 143:473-86. 2007
    ..Gene expression and epistasis analyses show that TIMING OF CHLOROPHYLL A/B BINDING PROTEIN1 (TOC1) expression is not solely dependent upon GI and that GI expression is only indirectly affected by TOC1, suggesting ..
  10. pmc Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE
    Eva Kevei
    Institute of Plant Biology, Biological Research Centre of the Hungarian Academy of Sciences, Szeged
    Plant Physiol 140:933-45. 2006
    ..interactions with previously described partner proteins Arabidopsis S-phase kinase-related protein 1, TIMING OF CAB EXPRESSION 1, and PHYB. Interaction with PHYB was unaffected by mutation of any ZTL domain...
  11. doi Functional implication of the MYB transcription factor RVE8/LCL5 in the circadian control of histone acetylation
    Benoit Farinas
    Centre for Research in Agricultural Genomics CRAG, Consortium CSIC IRTA UAB, C Jordi Girona 18 26, 08034 Barcelona, Spain
    Plant J 66:318-29. 2011
    ..Similar to CCA1, RVE8/LCL5 regulates the expression of the oscillator gene TOC1 (TIMING OF CAB EXPRESSION1) by associating with the TOC1 promoter and by modulating the pattern of histone 3 (H3) ..
  12. pmc Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor
    Joshua M Gendron
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0130, USA
    Proc Natl Acad Sci U S A 109:3167-72. 2012
    ..described feedback loop of the Arabidopsis circadian clock is based on reciprocal regulation between Timing of CAB Expression 1 (TOC1) and Circadian Clock-associated 1 (CCA1)/late elongated hypocotyl (LHY)...
  13. pmc The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
    Alexandra Pokhilko
    School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Syst Biol 8:574. 2012
    ..Pseudo-Response Regulator 9 was repressed by an evening gene, previously identified with Timing Of CAB Expression1 (TOC1)...
  14. doi Mapping the core of the Arabidopsis circadian clock defines the network structure of the oscillator
    W Huang
    Center for Research in Agricultural Genomics, Barcelona 08193, Spain
    Science 336:75-9. 2012
    ..In Arabidopsis, oscillator coupling relies on a core loop in which the evening oscillator component TIMING OF CAB EXPRESSION 1 (TOC1) was proposed to activate a subset of morning-expressed oscillator genes...
  15. ncbi Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana
    Paloma Mas
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 426:567-70. 2003
    ..we provide genetic and molecular evidence for a role of ZEITLUPE (ZTL) in the targeted degradation of TIMING OF CAB EXPRESSION 1 (TOC1) in Arabidopsis thaliana (thale cress)...
  16. ncbi Characterization of the APRR9 pseudo-response regulator belonging to the APRR1/TOC1 quintet in Arabidopsis thaliana
    Shogo Ito
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 44:1237-45. 2003
    ..TOC1 is a member of a small family of proteins, designated as ARABIDOPSIS PSEUDO-RESPONSE REGULATORS (APRR1/TOC1, APRR3, APRR5, APRR7, and APRR9)...
  17. ncbi The APRR1/TOC1 quintet implicated in circadian rhythms of Arabidopsis thaliana: I. Characterization with APRR1-overexpressing plants
    Seiya Makino
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 43:58-69. 2002
    ..the Myb-related CCA1 and LHY transcription factors and a member of the novel family of pseudo response regulators (APRR1/TOC1)...
  18. ncbi Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog
    C Strayer
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 289:768-71. 2000
    The toc1 mutation causes shortened circadian rhythms in light-grown Arabidopsis plants. Here, we report the same toc1 effect in the absence of light input to the clock...
  19. pmc A complex genetic interaction between Arabidopsis thaliana TOC1 and CCA1/LHY in driving the circadian clock and in output regulation
    Zhaojun Ding
    Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Genetics 176:1501-10. 2007
    ..been proposed that CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) together with TIMING OF CAB EXPRESSION 1 (TOC1) make up the central oscillator of the Arabidopsis thaliana circadian clock...
  20. pmc PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock
    Lei Wang
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, OH, USA
    EMBO J 29:1903-15. 2010
    ..b>TOC1/PRR1, a pseudoresponse regulator (PRR) protein, is a central element in one of the feedback loops of the ..
  21. pmc Molecular convergence of clock and photosensory pathways through PIF3-TOC1 interaction and co-occupancy of target promoters
    Judit Soy
    Center for Research in Agricultural Genomics, Consejo Superior de Investigaciones Científicas CRAG, CSIC, Bellaterra, 08193 Barcelona, Spain
    Proc Natl Acad Sci U S A 113:4870-5. 2016
    ..Here we show that the PIFs and the core clock component Timing of CAB expression 1 (TOC1) display coincident cobinding to the promoters of predawn-phased, growth-related genes under SD ..
  22. pmc Accurate timekeeping is controlled by a cycling activator in Arabidopsis
    Polly Yingshan Hsu
    Department of Plant Biology, University of California, Davis, Davis, United States
    elife 2:e00473. 2013
    ..Further, our work suggests that the plant clock consists of a highly interconnected, complex regulatory network rather than of coupled morning and evening feedback loops. DOI:http://dx.doi.org/10.7554/eLife.00473.001...
  23. pmc LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis circadian oscillator
    QiGuang Xie
    Hebei Key Laboratory of Molecular and Cellular Biology, Key Laboratory of Molecular and Cellular Biology of the Ministry of Education, College of Life Sciences, Hebei Normal University, Hebei Collaboration Innovation Center for Cell Signaling, Shijiazhuang, Hebei 050024, China
    Plant Cell 26:2843-57. 2014
    ..activators of central clock components, including PSEUDO-RESPONSE REGULATOR5 (PRR5) and TIMING OF CAB EXPRESSION1 (TOC1)...
  24. doi A genetic study of the Arabidopsis circadian clock with reference to the TIMING OF CAB EXPRESSION 1 (TOC1) gene
    Shogo Ito
    Nagoya University, Chikusa ku, Japan
    Plant Cell Physiol 50:290-303. 2009
    ..This tentative model consists of three interactive feedback loops, namely the core CCA1/LHY-TOC1/X loop, the morning CCA1/LHY-PRR9/PRR7 loop and the evening Y-TOC1 loop, in which the undefined Y gene might be GI...
  25. pmc AtHESPERIN: a novel regulator of circadian rhythms with poly(A)-degrading activity in plants
    Costas Delis
    a Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, 412 21, Greece
    RNA Biol 13:68-82. 2016
    ..overexpression of AtHESP in plant lines affects the expression and rhythmicity of the clock core oscillator genes TOC1 and CCA1...
  26. pmc Circadian clock regulates dynamic chromatin modifications associated with Arabidopsis CCA1/LHY and TOC1 transcriptional rhythms
    Hans Hemmes
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, NY 10065 6399, USA
    Plant Cell Physiol 53:2016-29. 2012
    ..CIRCADIAN CLOCK ASSOCIATED 1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB EXPRESSION 1 (TOC1) reciprocally repress genes encoding each other and are critical for the generation of circadian ..
  27. pmc Rhythmic oscillation of histone acetylation and methylation at the Arabidopsis central clock loci
    Hae Ryong Song
    School of Biological Sciences, Seoul National University, Seoul, 151 747, Korea
    Mol Cells 34:279-87. 2012
    ..Translated LHY and CCA1 proteins repress the expression of TIMING OF CAB EXPRESSION 1 (TOC1), which peaks in the evening...
  28. pmc Circadian rhythms of ethylene emission in Arabidopsis
    Simon C Thain
    Unit Plant Hormone Signaling and Bio Imaging, Department of Molecular Genetics, University of Ghent, Belgium
    Plant Physiol 136:3751-61. 2004
    ..In addition, ethylene production is controlled by the TIMING OF CAB EXPRESSION 1 and CIRCADIAN CLOCK ASSOCIATED 1 genes, which are critical for all circadian rhythms yet tested in ..
  29. ncbi Interactions of the developmental regulator ABI3 with proteins identified from developing Arabidopsis seeds
    S Kurup
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, UK
    Plant J 21:143-55. 2000
    ..All the AIPs show homology to existing transcription factors and therefore they may function with ABI3 within the network of transcriptional regulators that control embryo development in Arabidopsis...
  30. ncbi Circadian waves of expression of the APRR1/TOC1 family of pseudo-response regulators in Arabidopsis thaliana: insight into the plant circadian clock
    A Matsushika
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Japan
    Plant Cell Physiol 41:1002-12. 2000
    The Arabidopsis pseudo-response regulator, APRR1, has a unique structural design containing a pseudo-receiver domain and a C-terminal CONSTANS motif...
  31. ncbi The APRR1/TOC1 quintet implicated in circadian rhythms of Arabidopsis thaliana: II. Characterization with CCA1-overexpressing plants
    Akinori Matsushika
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 43:118-22. 2002
    ..a novel class of proteins, named pseudo-response regulators (APRRs) in Arabidopsis thaliana, each of which (APRR1, APRR3, APRR5, APRR7, and APRR9) has an intriguing structural design containing an N-terminal pseudo receiver ..
  32. ncbi A Link between circadian-controlled bHLH factors and the APRR1/TOC1 quintet in Arabidopsis thaliana
    Takafumi Yamashino
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 44:619-29. 2003
    APRR1 (ARABIDPSIS PSUEDO-RESPONSE REGULATOR 1) (or TOC1, TIMING OF CAB EXPRESSION 1) is believed to be a crucial component of biological clocks of Arabidopsis thaliana. Nevertheless, its molecular function remains to be fully elucidated...
  33. ncbi Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis
    Masahiro Yasuhara
    Gene Research Center, Kagawa University, 2393 Ikenobe, Miki cho Kita gun, Kagawa 761 0795, Japan
    J Exp Bot 55:2015-27. 2004
    ..The two-hybrid analysis also demonstrated that LKP2 interacted with TOC1, a clock component, but not with CCA1 or LHY, negative regulators of TOC1 gene expression...
  34. ncbi Circadian-controlled basic/helix-loop-helix factor, PIL6, implicated in light-signal transduction in Arabidopsis thaliana
    Toru Fujimori
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 45:1078-86. 2004
    ..circadian-controlled transcription factor was previously suggested to interact with the clock component, TIMING OF CAB EXPRESSION 1 (TOC1)...
  35. doi Insight into missing genetic links between two evening-expressed pseudo-response regulator genes TOC1 and PRR5 in the circadian clock-controlled circuitry in Arabidopsis thaliana
    Shogo Ito
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 49:201-13. 2008
    ..Among them, the evening-expressed TOC1 (TIMING OF CAB EXPRESSION 1) gene plays a role by forming a transcriptional feedback core loop together with the morning-expressed ..
  36. pmc Histone acetylation and the circadian clock: a role for the MYB transcription factor RVE8/LCL5
    Benoit Farinas
    Centre for Research in Agricultural Genomics, Plant Molecular Genetics, Barcelona, Spain
    Plant Signal Behav 6:541-3. 2011
    ..factor CIRCADIAN CLOCK-ASSOCIATED1 (CCA1), RVE8/LCL5 binds to the promoter of key clock component TOC1 (Timing of CAB expression 1) and regulates its circadian expression...
  37. pmc JMJD5 Functions in concert with TOC1 in the arabidopsis circadian system
    Matthew A Jones
    Department of Plant Biology, College of Biological Sciences, University of California, Davis, California, USA
    Plant Signal Behav 6:445-8. 2011
    ..recently identified a novel component of the Arabidopsis circadian clock, JMJD5, based on its coexpression with TOC1, an evening-phased component of the molecular oscillator...
  38. pmc Partners in time: EARLY BIRD associates with ZEITLUPE and regulates the speed of the Arabidopsis clock
    Mikael Johansson
    Department of Plant Physiology, Umea Plant Science Centre, Umea University, SE 901 87 Umea, Sweden
    Plant Physiol 155:2108-22. 2011
    ..This work highlights the importance of cross talk between the ubiquitination pathway and transcriptional control for regulation of the plant clock...
  39. ncbi Circadian rhythm of circumnutation in inflorescence stems of Arabidopsis
    Kanae Niinuma
    Plant Science Center, RIKEN, 1 7 22 Suehiro, Tsurumi, Yokohama, Kanagawa, 230 0045 Japan
    Plant Cell Physiol 46:1423-7. 2005
    ..b>toc1 appears to shorten the period and elf3 causes an arrhythmic phenotype in circumnutation speed in LL, suggesting ..
  40. pmc TIME FOR COFFEE encodes a nuclear regulator in the Arabidopsis thaliana circadian clock
    Zhaojun Ding
    Department of Plant Developmental Biology, Max Planck Institute for Plant Breeding Research, Cologne D 50829, Germany
    Plant Cell 19:1522-36. 2007
    ..Neither its abundance nor its cellular distribution was found to be clock regulated. We suggest that TIC encodes a nucleus-acting clock regulator working close to the central oscillator...
  41. ncbi Genetic linkages of the circadian clock-associated genes, TOC1, CCA1 and LHY, in the photoperiodic control of flowering time in Arabidopsis thaliana
    Yusuke Niwa
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 48:925-37. 2007
    ..Nevertheless, the genetic linkages between the major clock-associated TOC1, CCA1 and LHY genes and the canonical CO-FT flowering pathway are less clear...
  42. pmc A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock
    Jose L Pruneda-Paz
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Science 323:1481-5. 2009
    ..In Arabidopsis, a core loop is established between CCA1 and TOC1. Although CCA1 directly represses TOC1, the TOC1 protein has no DNA binding domains, which suggests that it cannot ..