ZTL

Summary

Gene Symbol: ZTL
Description: Galactose oxidase/kelch repeat superfamily protein
Alias: ADAGIO 1, ADO1, FKF1-LIKE PROTEIN 2, FKL2, LKP1, LOV KELCH PROTEIN 1, MSF19.2, MSF19_2, ZEITLUPE
Species: thale cress

Top Publications

  1. ncbi ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology Plant Biotechnology Center, Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, Ohio 43210, USA
    Nature 449:356-60. 2007
  2. pmc Independent roles for EARLY FLOWERING 3 and ZEITLUPE in the control of circadian timing, hypocotyl length, and flowering time
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology, Plant Biotechnology Center, Ohio State University, Columbus, OH 43210, USA
    Plant Physiol 139:1557-69. 2005
  3. doi Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins
    Sumire Fujiwara
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:23073-83. 2008
  4. ncbi ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis
    D E Somers
    The Scripps Research Institute, Department of Cell Biology, La Jolla, California 92037, USA
    Cell 101:319-29. 2000
  5. ncbi Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana
    Paloma Mas
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 426:567-70. 2003
  6. pmc F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression
    Antoine Baudry
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Plant Cell 22:606-22. 2010
  7. pmc Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE
    Eva Kevei
    Institute of Plant Biology, Biological Research Centre of the Hungarian Academy of Sciences, Szeged
    Plant Physiol 140:933-45. 2006
  8. pmc GIGANTEA acts in blue light signaling and has biochemically separable roles in circadian clock and flowering time regulation
    Ellen L Martin-Tryon
    Section of Plant Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Plant Physiol 143:473-86. 2007
  9. pmc Targeted degradation of PSEUDO-RESPONSE REGULATOR5 by an SCFZTL complex regulates clock function and photomorphogenesis in Arabidopsis thaliana
    Takatoshi Kiba
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, New York 10065 6399, USA
    Plant Cell 19:2516-30. 2007
  10. pmc PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock
    Alessia Para
    Department of Biochemistry, Scripps Research Institute, La Jolla, California 92037, USA
    Plant Cell 19:3462-73. 2007

Detail Information

Publications27

  1. ncbi ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology Plant Biotechnology Center, Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, Ohio 43210, USA
    Nature 449:356-60. 2007
    ..Rhythmic expression of the Arabidopsis thaliana F-box protein ZEITLUPE (ZTL) is necessary to sustain a normal circadian period by controlling the proteasome-dependent degradation of a ..
  2. pmc Independent roles for EARLY FLOWERING 3 and ZEITLUPE in the control of circadian timing, hypocotyl length, and flowering time
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology, Plant Biotechnology Center, Ohio State University, Columbus, OH 43210, USA
    Plant Physiol 139:1557-69. 2005
    ..b>ZEITLUPE (ZTL) is a clock-related F-box protein, and altered ZTL expression causes fluence rate-dependent circadian period ..
  3. doi Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins
    Sumire Fujiwara
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:23073-83. 2008
    ..The more highly phosphorylated forms of PRR5 and TOC1 interact best with the F-box protein ZTL (ZEITLUPE), suggesting a mechanism to modulate their proteolysis...
  4. ncbi ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis
    D E Somers
    The Scripps Research Institute, Department of Cell Biology, La Jolla, California 92037, USA
    Cell 101:319-29. 2000
    ..This screen identified mutations at a locus, ZEITLUPE (ZTL), that lengthen the free-running period of clock-controlled gene transcription and cell expansion, and alter ..
  5. ncbi Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana
    Paloma Mas
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 426:567-70. 2003
    ..Here we provide genetic and molecular evidence for a role of ZEITLUPE (ZTL) in the targeted degradation of TIMING OF CAB EXPRESSION 1 (TOC1) in Arabidopsis thaliana (thale cress)...
  6. pmc F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression
    Antoine Baudry
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Plant Cell 22:606-22. 2010
    Regulation of protein turnover mediated by ZEITLUPE (ZTL) constitutes an important mechanism of the circadian clock in Arabidopsis thaliana...
  7. pmc Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE
    Eva Kevei
    Institute of Plant Biology, Biological Research Centre of the Hungarian Academy of Sciences, Szeged
    Plant Physiol 140:933-45. 2006
    ..of these loops remain to be identified; none of the known components is completely understood, including ZEITLUPE (ZTL), a gene implicated in regulated protein degradation...
  8. pmc GIGANTEA acts in blue light signaling and has biochemically separable roles in circadian clock and flowering time regulation
    Ellen L Martin-Tryon
    Section of Plant Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Plant Physiol 143:473-86. 2007
    ..Using a clock-regulated luciferase reporter, we isolated new alleles of ZEITLUPE, LATE ELONGATED HYPOCOTYL, and GIGANTEA (GI)...
  9. pmc Targeted degradation of PSEUDO-RESPONSE REGULATOR5 by an SCFZTL complex regulates clock function and photomorphogenesis in Arabidopsis thaliana
    Takatoshi Kiba
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, New York 10065 6399, USA
    Plant Cell 19:2516-30. 2007
    ..We demonstrated that the Pseudo-Receiver (PR) domain of PRR5 interacts directly with the F box protein ZEITLUPE (ZTL) in vitro and in vivo...
  10. pmc PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock
    Alessia Para
    Department of Biochemistry, Scripps Research Institute, La Jolla, California 92037, USA
    Plant Cell 19:3462-73. 2007
    ..PRR3 was able to bind to TOC1 in yeast and in plants and to perturb TOC1 interaction with ZEITLUPE (ZTL), which targets TOC1 for proteasome-dependent degradation...
  11. pmc Gene expression profile of zeitlupe/lov kelch protein1 T-DNA insertion mutants in Arabidopsis thaliana: Downregulation of auxin-inducible genes in hypocotyls
    Aya Saitoh
    a Department of Life Science Faculty of Science Gakushuin University Tokyo, Japan
    Plant Signal Behav 10:e1071752. 2015
    ..b>ZEITLUPE (ZTL) or LOV KELCH PROTEIN1 (LKP1) is a positive regulator of warmth-induced hypocotyl elongation under white ..
  12. pmc ZEITLUPE positively regulates hypocotyl elongation at warm temperature under light in Arabidopsis thaliana
    Yuji Miyazaki
    a Department of Life Science Faculty of Science Gakushuin University Tokyo, Japan
    Plant Signal Behav 10:e998540. 2015
    ..Proteins of the flavin-binding KELCH repeat F-box 1 / LOV KELCH protein 2 / ZEITLUPE family are positive regulators of hypocotyl elongation under red light in Arabidopsis...
  13. pmc Arabidopsis TOE proteins convey a photoperiodic signal to antagonize CONSTANS and regulate flowering time
    Bailong Zhang
    State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Institute of Plant Biology, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai 200438, China Ministry of Education Key Laboratory of Biodiversity and Ecological Engineering, Institute of Biodiversity Sciences, Fudan University, Shanghai 200438, China
    Genes Dev 29:975-87. 2015
    ..In addition, TOE1 interacts with the LOV domain of FKF1 and likely interferes with the FKF1-CO interaction, resulting in partial degradation of the CO protein in the afternoon to prevent premature flowering...
  14. pmc Distinct roles of FKF1, Gigantea, and Zeitlupe proteins in the regulation of Constans stability in Arabidopsis photoperiodic flowering
    Young Hun Song
    Departments of Biology and Department of Life Sciences, Ajou University, Suwon 443 749, Korea and
    Proc Natl Acad Sci U S A 111:17672-7. 2014
    ..Here we demonstrated that the FKF1-interacting proteins Gigantea (GI) and Zeitlupe (ZTL) are involved in CO stability regulation...
  15. pmc Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms
    Hongtao Liu
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China
    Proc Natl Acad Sci U S A 110:17582-7. 2013
    ..Instead, two of the three light-oxygen-voltage (LOV)-domain photoreceptors, ZEITLUPE and LOV KELCH PROTEIN 2, but not FLAVIN-BINDING KELCH REPEAT 1, are required for the function and blue-light ..
  16. doi Zeitlupe senses blue-light fluence to mediate circadian timing in Arabidopsis thaliana
    Ashutosh Pudasaini
    Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States
    Biochemistry 52:7150-8. 2013
    ..The Zeitlupe (ZTL), Flavin-Kelch-Fbox-1 (FKF1), and LOV-Kelch-Protein-2 (LKP2) proteins dictate measurement of the day length, ..
  17. ncbi A high-throughput system for two-hybrid screening based on growth curve analysis in microtiter plates
    Claudia Diaz-Camino
    Gene Expression Group, Plant Biotechnology Institute, National Research Council Canada, 110 Gymnasium Place, Saskatoon, SK, Canada S7N 0W9
    Anal Biochem 316:171-4. 2003
    ....
  18. ncbi LKP1 (LOV kelch protein 1): a factor involved in the regulation of flowering time in arabidopsis
    T Kiyosue
    Gene Research Center, Kagawa University, Miki cho, Kita gun, Kagawa 761 0795, Japan
    Plant J 23:807-15. 2000
    ..Here, we report a putative photo-regulatory factor sequence in LKP1 (LOV kelch protein 1)...
  19. pmc The F-box protein ZEITLUPE controls stability and nucleocytoplasmic partitioning of GIGANTEA
    Jeongsik Kim
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Development 140:4060-9. 2013
    ..Previous work has shown that the F-box protein ZEITLUPE (ZTL) and clock element GIGANTEA (GI) heterodimerize in the cytosol, thereby stabilizing ZTL...
  20. pmc PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock
    Lei Wang
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, OH, USA
    EMBO J 29:1903-15. 2010
    ..g. timeless/period and clock/cycle), suggesting evolutionary convergence of a conserved mechanism across kingdoms...
  21. pmc Partners in time: EARLY BIRD associates with ZEITLUPE and regulates the speed of the Arabidopsis clock
    Mikael Johansson
    Department of Plant Physiology, Umea Plant Science Centre, Umea University, SE 901 87 Umea, Sweden
    Plant Physiol 155:2108-22. 2011
    ..We show that EBI associates with ZEITLUPE (ZTL), known to act in the plant clock as a posttranslational mediator of protein degradation...
  22. doi LOV KELCH PROTEIN2 and ZEITLUPE repress Arabidopsis photoperiodic flowering under non-inductive conditions, dependent on FLAVIN-BINDING KELCH REPEAT F-BOX1
    Tomoyuki Takase
    Department of Life Science, Faculty of Science, Gakushuin University, 1 5 1 Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Plant J 67:608-21. 2011
    LOV KELCH PROTEIN2 (LKP2), ZEITLUPE (ZTL)/LOV KELCH PROTEIN1 (LKP1) and FLAVIN-BINDING KELCH REPEAT F-BOX1 (FKF1) constitute a family of Arabidopsis F-box proteins that regulate the circadian clock...
  23. pmc HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE
    Tae Sung Kim
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 108:16843-8. 2011
    ..Here we show that the Arabidopsis circadian clock-associated F-box protein ZEITLUPE (ZTL) is a unique client for cytoplasmic HSP90...
  24. ncbi Identification of LOV KELCH PROTEIN2 (LKP2)-interacting factors that can recruit LKP2 to nuclear bodies
    Yosuke Fukamatsu
    Division of Gene Research, Life Science Research Center, Kagawa University, 2393 Ikenobe, Miki cho Kita gun, Kagawa, 761 0795 Japan
    Plant Cell Physiol 46:1340-9. 2005
    ..COL1 and other CO/COL family proteins could also interact with LKP1/ZTL, LKP2 or FKF1. The LKP2-binding site in CO or COL1 was near the center of each protein...
  25. ncbi Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing
    Linqu Han
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, OH, USA
    Plant J 40:291-301. 2004
    ..In Arabidopsis a novel F-box protein, ZEITLUPE (ZTL), plays an important role in the control of the free-running period of the circadian clock...
  26. ncbi Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis
    Masahiro Yasuhara
    Gene Research Center, Kagawa University, 2393 Ikenobe, Miki cho Kita gun, Kagawa 761 0795, Japan
    J Exp Bot 55:2015-27. 2004
    ..LKP2 interacted not only with itself but also with other members of the family, LKP1 and FKF1...
  27. ncbi An Arabidopsis circadian clock component interacts with both CRY1 and phyB
    J A Jarillo
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    Nature 410:487-90. 2001
    ..Here we describe ADAGIO1 (ADO1), a gene of Arabidopsis thaliana that encodes a protein containing a PAS domain...