Genomes and Genes
Gene Symbol: Tb11.01.5940
Description: exportin 1
Species: Trypanosoma brucei TREU927
- Exportin 1 mediates nuclear export of the kinetoplastid spliced leader RNAGusti M Zeiner
Department of Microbiology, University of California at Los Angeles, Los Angeles, California 90095 1489, USA
Eukaryot Cell 2:222-30. 2003..This study demonstrates spatial and mechanistic similarities between the posttranscriptional trafficking of the kinetoplastid protozoan SL RNA and the metazoan cis-spliceosomal small nuclear RNAs...
- RNAi interference of XPO1 and Sm genes and their effect on the spliced leader RNA in Trypanosoma bruceiMoshe Biton
The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
Mol Biochem Parasitol 150:132-43. 2006..Only after massive nuclear accumulation is the 'defective' SL RNA exported to the cytoplasm to form SL RNP-C, which may be a route to dispose of SL RNA when its normal biogenesis is blocked...
- Trypanosoma brucei RNA binding proteins p34 and p37 mediate NOPP44/46 cellular localization via the exportin 1 nuclear export pathwayKristina Hellman
Department of Microbiology and Immunology and The Witebsky Center for Microbial Pathogenesis and Immunology, 253 Biomedical Research Building, University at Buffalo, Buffalo, New York 14214, USA
Eukaryot Cell 6:2206-13. 2007..Together, our results demonstrate that p34 and p37 regulate NOPP44/46 cellular localization by facilitating their association with exportin 1...