Social, Genetic Determinants of Blood Pressure in Underserved African Americans

Summary

Principal Investigator: SANDRA MARIE COULON
Abstract: DESCRIPTION (provided by applicant): High blood pressure (BP) is present in up to 78% of older adults in the United States, is more prevalent in African Americans than other ethnic groups, and is a leading cause of cardiovascular disease mortality. Social- environmental stress and social support factors, such as individual socioeconomic status (SES), have been linked to high BP, as have related physiological mechanisms such as hypothalamic-pituitary-adrenal (HPA) secretion of glucocorticoid stress hormones (e.g. cortisol), and genetic factors such as polymorphisms in glucocorticoid receptor (GR) genes. However, few studies have integrated these factors in African Americans, and social-environmental factors have often been measured at the individual- but not at the community-level, giving little insight into community factors (e.g. community SES) relevant to population-level efforts to understand BP regulatory mechanisms and health disparities. Investigating how these factors interact to influence BP outcomes may afford a better understanding of BP etiology and contribute to successful prevention efforts. Additionally, ecological, psychosocial, and biological theories of health may guide such an integrated investigation. Thus, the aim of the proposed study is to examine how community-level social- environmental factors interact with GR polymorphisms to predict cortisol and high BP, and whether cortisol mediates the association of social-environmental factors with BP as an underlying physiologic mechanism, as has been well established in clinical and experimental models. Data for each variable will be collected within an existing sample of older adult African Americans (N=434;Mage=51.2 years) nested within three communities as part of the on-going NIH-funded PATH trial. The PI of the trial, Dr. Dawn Wilson, is the primary sponsor of this application. Participants will attend health screenings during which data for target variables will be collected. Social-environmental variables will include census-derived community-level SES, community crime rates, and community connectedness measured via questionnaire. Saliva samples will allow measurement of morning and afternoon cortisol as a marker of basal HPA functioning and stress. Genomic DNA for three single nucleotide polymorphisms (SNPs) previously linked to social-environmental and physiologic mechanisms of high BP (Bcl1, rs 41423247;FKBP5, rs1360780;92, rs6198) will be extracted from buccal swab samples and assayed via polymerase chain reaction, under the guidance of Dr. Matthew Kostek, a co-sponsor of this application. Structural equation modeling and regression will be applied to test stated study aims and hypotheses, with relevant covariates such as BP medication status, age, and sex included in statistical models. Potential clustering by community will be controlled by examining intra-class correlation coefficients. Thus, through the integrated study of social-environmental, physiologic, and genetic factors, this investigation will contribute to a comprehensive conceptualization of high BP and disparity in underserved African American populations, and has the potential to inform innovative prevention approaches and public policy.
Funding Period: 2011-08-16 - 2014-10-15
more information: NIH RePORT

Top Publications

  1. pmc Formative process evaluation for implementing a social marketing intervention to increase walking among African Americans in the Positive Action for Today's Health trial
    Sandra M Coulon
    Department of Psychology, Barnwell College, University of South Carolina, Columbia, SC 29208, USA
    Am J Public Health 102:2315-21. 2012
  2. pmc Imputational modeling of spatial context and social environmental predictors of walking in an underserved community: the PATH trial
    Dawn K Wilson
    University of South Carolina, Psychology Department, Barnwell College, Columbia, SC 29208, United States
    Spat Spatiotemporal Epidemiol 4:15-23. 2013
  3. pmc Qualitative developmental research among low income African American adults to inform a social marketing campaign for walking
    Dawn K Wilson
    Department of Psychology, University of South Carolina, Columbia, SC 29208, USA
    Int J Behav Nutr Phys Act 10:33. 2013
  4. pmc Associations among environmental supports, physical activity, and blood pressure in African-American adults in the PATH trial
    Sandra M Coulon
    Department of Psychology, University of South Carolina, Barnwell College, Columbia, SC 29208, USA
    Soc Sci Med 87:108-15. 2013
  5. pmc Physical activity as a mediator linking neighborhood environmental supports and obesity in African Americans in the path trial
    E Rebekah Siceloff
    Department of Psychology, University of South Carolina
    Health Psychol 33:481-9. 2014

Research Grants

  1. The Shelf Live Evaluation of Investigational Dosage Forms
    Jonathan White; Fiscal Year: 2013
  2. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
  3. Psychosocial Factors in Reproductive Aging
    Maria E Bleil; Fiscal Year: 2013
  4. Molecular and Epidemiologic Basis of UTI in Women
    Scott J Hultgren; Fiscal Year: 2013
  5. Models For Tobacco Product Evaluation
    Peter G Shields; Fiscal Year: 2013
  6. Center for Stroke Disaparities Solution
    Olajide Williams; Fiscal Year: 2013
  7. Boston Puerto Rican Health Study - CVD Risk Factors
    Katherine L Tucker; Fiscal Year: 2013
  8. Caloric Restricted Rodent Colony
    RICK MORIN; Fiscal Year: 2013
  9. An Implementation and Biobehavioral Study of TMJMD
    ROBERT JOSEPH GATCHEL; Fiscal Year: 2013
  10. Establishing a Center of Excellence on Health Disparities in Rural Populations
    Jacob C Warren; Fiscal Year: 2013

Detail Information

Publications5

  1. pmc Formative process evaluation for implementing a social marketing intervention to increase walking among African Americans in the Positive Action for Today's Health trial
    Sandra M Coulon
    Department of Psychology, Barnwell College, University of South Carolina, Columbia, SC 29208, USA
    Am J Public Health 102:2315-21. 2012
    ..We report formative process evaluation methods and implementation dose, fidelity, and reach in the Positive Action for Today's Health trial...
  2. pmc Imputational modeling of spatial context and social environmental predictors of walking in an underserved community: the PATH trial
    Dawn K Wilson
    University of South Carolina, Psychology Department, Barnwell College, Columbia, SC 29208, United States
    Spat Spatiotemporal Epidemiol 4:15-23. 2013
    ..This study examined imputational modeling effects of spatial proximity and social factors of walking in African American adults...
  3. pmc Qualitative developmental research among low income African American adults to inform a social marketing campaign for walking
    Dawn K Wilson
    Department of Psychology, University of South Carolina, Columbia, SC 29208, USA
    Int J Behav Nutr Phys Act 10:33. 2013
    ..This study describes the development of a social marketing campaign for increasing walking in a low income, high crime community as part of the Positive Action for Today's Health (PATH) trial...
  4. pmc Associations among environmental supports, physical activity, and blood pressure in African-American adults in the PATH trial
    Sandra M Coulon
    Department of Psychology, University of South Carolina, Barnwell College, Columbia, SC 29208, USA
    Soc Sci Med 87:108-15. 2013
    ....
  5. pmc Physical activity as a mediator linking neighborhood environmental supports and obesity in African Americans in the path trial
    E Rebekah Siceloff
    Department of Psychology, University of South Carolina
    Health Psychol 33:481-9. 2014
    ..Social and environmental supports for PA may be important to increase PA. This study hypothesized that PA would mediate the effects of neighborhood and social supports for PA on body mass index (BMI)...

Research Grants30

  1. The Shelf Live Evaluation of Investigational Dosage Forms
    Jonathan White; Fiscal Year: 2013
    ..This contract is essential for continued assurance of the quality of drugs undergoing clinical investigation for different types of cancer by Cancer Therapeutics Evaluation Program. ..
  2. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..abstract_text> ..
  3. Psychosocial Factors in Reproductive Aging
    Maria E Bleil; Fiscal Year: 2013
    ..Results will elucidate possible modifiable risk factors for accelerated ovarian aging underlying earlier onset menopause. ..
  4. Molecular and Epidemiologic Basis of UTI in Women
    Scott J Hultgren; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Not provided ..
  5. Models For Tobacco Product Evaluation
    Peter G Shields; Fiscal Year: 2013
    ..e., sex, age, race/ethnicity) affects uptake and use and resulting toxicant exposure. ..
  6. Center for Stroke Disaparities Solution
    Olajide Williams; Fiscal Year: 2013
    ....
  7. Boston Puerto Rican Health Study - CVD Risk Factors
    Katherine L Tucker; Fiscal Year: 2013
    ..abstract_text> ..
  8. Caloric Restricted Rodent Colony
    RICK MORIN; Fiscal Year: 2013
    ..The purpose of this project is to develop, maintain and distribute a standing colony ofaged, calorically restricted rodents ofdefined strains for use by investigators in studies of aging. ..
  9. An Implementation and Biobehavioral Study of TMJMD
    ROBERT JOSEPH GATCHEL; Fiscal Year: 2013
    ..Results from this component of the project will greatly aid in stimulating future research leading to the better understanding of TMJMD, as well as better tailoring of prescribed treatment regimens. ..
  10. Establishing a Center of Excellence on Health Disparities in Rural Populations
    Jacob C Warren; Fiscal Year: 2013
    ..The proposed activities of the Center of Excellence will collaboratively work to eliminate disparities among one of the largest health disparity populations in the United States. ..
  11. Risk for Dysfunctional Romantic Relationships for Adults
    Deborah M Capaldi; Fiscal Year: 2013
    ....
  12. HEALTHY AGING AND SENILE DEMENTIA
    John Morris; Fiscal Year: 2013
    ..Together, these projects and their supporting cores will focus on preclinical DAT in comparison with healthy brain aging and address the issue of detecting preclinical disease. ..
  13. Stress and Drug Use Vulnerability in the African American Community
    Ezemenari M Obasi; Fiscal Year: 2013
    ..Findings from this study will identify causal mechanisms of drug addictions that will advance theory, research, prevention, and treatments aimed at addressing this growing public health problem. ..
  14. Linking Biological and Social Pathways to Adolescent Health and Well-Being
    Jodi Ford; Fiscal Year: 2013
    ..In addition, these data will inform the design of future population research studies to reduce adolescent health risk and disparities, with potential health benefits over the life course. ..
  15. Stress, Gene-Environment Interaction and Cardiovascular Disease
    Belinda L Needham; Fiscal Year: 2013
    ..This approach is necessary to better understand the importance of stress and to develop preventative interventions. ..
  16. VCU NIMHD Comprehensive Center of Excellence
    Jerome F Strauss; Fiscal Year: 2013
    ..abstract_text> ..
  17. A Follow-up Study for Causes of Illness in Black Women
    Lynn Rosenberg; Fiscal Year: 2013
    ..Better understanding of the causes of the increased risks among U.S. black women should lead to more effective preventive measures and reductions in health disparities. ..
  18. BIOLOGY OF NEUROENDOCRINE PEPTIDES
    Marc R Montminy; Fiscal Year: 2013
    ..Specifying the contributions of the CRF family of ligands and receptors to the maintenance of homeostasis and to stress-linked allostasis may improve our ability to manage diseases, including mood and metabolic disorders ..
  19. Dissemination of Evidence-Based Health Disparity Interventions
    Ashwini Sehgal; Fiscal Year: 2013
    ..abstract_text> ..
  20. Novel Mechanisms of NSAID Action in Alzheimer's Disease
    Edward H Koo; Fiscal Year: 2013
    ..By providing additional preclinical and clinical information on GAMs, such studies should contribute significantly to the further development of GSMs as Alzheimer's therapeutics. ..