CENTER FOR BIOMEDICAL RESEARCH

Summary

Principal Investigator: Timothy Turner
Abstract: Overall Summary: The TU Center for Biomedical Research (CBR) is designed to strengthen the University's research infrastructure particularly in the areas of biomedical and molecular sciences as well as in bioinformatics and computational biology. Our goals are to: 1) Continue to strengthen the newly established PhD program in Integrative Biosciences (IBS) through acquisition of state-of-the-art molecular biology instrumentation and bioinformatics and computer modeling resources;2) to promote health disparity studies in the underserved rural communities of the black belt counties (BBC) of Alabama. The specific aims are: A) To strengthen and provide oversight for infrastructure development composed of Core 1: State-of-the-art Molecular Biology Shareable Laboratory Resources, Core 2;Bioinformatics and Computational Modeling Resources. B) To support IBS PhD students, and provide the infrastructure needed to create a first rate biomedical research environment. C) Based on our current areas of scientific expertise, to initiate four pilot research projects to study prostate cancer, HIV/AIDS and lupus by a team of about 12 junior and senior scientists. D) To develop and implement a Mentoring/Evaluation Program for junior faculty, staff and students led and managed by the PD, and the Advisory Committees, E) To implement an Evaluation Program to assess the productivity and accountability of the CBR over a period of five years by using both formative and summative outcomes. The proposed research relies upon innovative methods to include in-vitro (pilot #1, #2), in-vivo (pilot #2, #4) and computational dynamic modeling (pilot #3). The outcome is to increase the number of R01 or comparable research grant submissions by at least 50% from the current level of submissions and increasing publications in peer reviewed journals by at least 25% with an approved enforceable protocol that focuses on junior faculty development and productivity. The availability of advanced research equipment, coupled with the new knowledge generated via TU PhD students, scientists and collaborators will contribute to the reduction of selected health disparities in the BBC of Alabama.
Funding Period: 1997-07-07 - 2015-06-30
more information: NIH RePORT

Top Publications

  1. pmc Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival
    Khalda Fadlalla
    Department of Pathobiology, Center for Cancer Research, Tuskegee, AL 36088, USA
    Anticancer Res 31:233-41. 2011
  2. ncbi Customizable PCR-microplate array for differential identification of multiple pathogens
    Abdela Woubit
    Department of Pathobiology, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, Alabama 36088, USA
    J Food Prot 76:1948-57. 2013
  3. pmc Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas
    Kamel F Khazal
    Department of Biomedical Sciences, School of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Anticancer Res 33:1519-23. 2013
  4. pmc Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells
    Jacqueline Jones
    Department of Biology, Center for Cancer Research, Tuskegee University, Alabama, USA
    Am J Pathol 181:1836-46. 2012
  5. pmc A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and migration
    Prasanthi Karna
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Carcinogenesis 33:1769-81. 2012
  6. pmc Molecular cycloencapsulation augments solubility and improves therapeutic index of brominated noscapine in prostate cancer cells
    Jitender Madan
    Departments of Biology, Georgia State University, Atlanta, Georgia 30303, United States
    Mol Pharm 9:1470-80. 2012
  7. pmc Immunohistochemical evaluation of AKT protein activation in canine mast cell tumours
    S Rodriguez
    Department of Pathobiology, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA
    J Comp Pathol 147:171-6. 2012
  8. pmc Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas
    Venkat R Katkoori
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e30020. 2012
  9. pmc Clinical and biological significance of KISS1 expression in prostate cancer
    Honghe Wang
    Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, Alabama 36088, USA
    Am J Pathol 180:1170-8. 2012
  10. pmc Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells
    Temesgen Samuel
    Department of Pathobiology, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA
    Anticancer Res 32:61-71. 2012

Research Grants

  1. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth H Cowan; Fiscal Year: 2013

Detail Information

Publications17

  1. pmc Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival
    Khalda Fadlalla
    Department of Pathobiology, Center for Cancer Research, Tuskegee, AL 36088, USA
    Anticancer Res 31:233-41. 2011
    ..Ruta graveolens is a medicinal herb that has been used for centuries against various ailments. This study examined the anticancer properties of the herb using cancer cell lines...
  2. ncbi Customizable PCR-microplate array for differential identification of multiple pathogens
    Abdela Woubit
    Department of Pathobiology, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, Alabama 36088, USA
    J Food Prot 76:1948-57. 2013
    ..Such microplate arrays could be valuable tools for initial identification or secondary confirmation of contamination by these pathogens. ..
  3. pmc Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas
    Kamel F Khazal
    Department of Biomedical Sciences, School of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Anticancer Res 33:1519-23. 2013
    ..These results indicate that the root extract significantly reduced the rate of cell division in the mammary tumors...
  4. pmc Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells
    Jacqueline Jones
    Department of Biology, Center for Cancer Research, Tuskegee University, Alabama, USA
    Am J Pathol 181:1836-46. 2012
    ..Our findings establish a defined oncogenic role of Kaiso in promoting the progression of prostate cancer...
  5. pmc A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and migration
    Prasanthi Karna
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Carcinogenesis 33:1769-81. 2012
    ..This is the first report to describe a previously unrecognized, antiangiogenic property of a noscapinoid, EM011, and provides evidence for novel anticancer strategies recruited by microtubule-modulating drugs...
  6. pmc Molecular cycloencapsulation augments solubility and improves therapeutic index of brominated noscapine in prostate cancer cells
    Jitender Madan
    Departments of Biology, Georgia State University, Atlanta, Georgia 30303, United States
    Mol Pharm 9:1470-80. 2012
    ..This is the first report to demonstrate the novel construction of cylcodextrin-based nanosupramolecular vehicles for enhanced delivery of EM011 that warrants in vivo evaluation for the superior management of prostate cancer...
  7. pmc Immunohistochemical evaluation of AKT protein activation in canine mast cell tumours
    S Rodriguez
    Department of Pathobiology, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA
    J Comp Pathol 147:171-6. 2012
    ..This study suggests that canine MCT cells have activated AKT and indicates the need for further research on the role of the AKT protein and the possibility of targeting the AKT signalling pathway in MCTs...
  8. pmc Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas
    Venkat R Katkoori
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e30020. 2012
    ..p53 mutations are associated with poor survival of patients with Stage III MSS CRCs and p53-mutant and wild-type phenotypes have distinct gene expression profiles that might be helpful in identifying aggressive subsets...
  9. pmc Clinical and biological significance of KISS1 expression in prostate cancer
    Honghe Wang
    Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, Alabama 36088, USA
    Am J Pathol 180:1170-8. 2012
    ..Collectively, our data suggest that KISS1 functions as a metastasis suppressor in PCas and may serve as a useful biomarker as well as a therapeutic target for aggressive PCas...
  10. pmc Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells
    Temesgen Samuel
    Department of Pathobiology, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA
    Anticancer Res 32:61-71. 2012
    ..DNA-damaging drugs constitute standard chemotherapy regimen for advanced colorectal cancer. Here, the interactions between quercetin and 5-fluorouracil (5-FU), etoposide, and camptothecin were examined in cancer cells...
  11. pmc Detecting gene-gene interactions in prostate disease in African American men
    R Renee Reams
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, Florida, USA
    Infect Agent Cancer 6:S1. 2011
    ....
  12. pmc Side population rather than CD133(+) cells distinguishes enriched tumorigenicity in hTERT-immortalized primary prostate cancer cells
    Jianjun Zhou
    Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA
    Mol Cancer 10:112. 2011
    ..Therefore the aim of this work was to determine, in prostate cancer cell lines, the frequency and tumorigenic potential of SP and CD133+ cells...
  13. pmc A quantitative risk assessment of multiple factors influencing HIV/AIDS transmission through unprotected sex among HIV-seropositive men
    Gemechu B Gerbi
    Center for Computational Epidemiology, Bioinformatics and Risk Analysis, Tuskegee University, USA
    AIDS Care 24:331-9. 2012
    ..23 × 10(-8) and 3.58 × 10(-8), respectively. The findings suggest that HIV/AIDS research and intervention programs must be focused on behavior, and the broader setting within which individual risky behaviors occur...
  14. ncbi The stomach and/or upper duodenum contain sites of action that control meal size and intermeal interval length by exogenous rat gastrin releasing peptide
    Martha C Washington
    Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, United States
    Peptides 55:41-6. 2014
    ..These results support an upper gastrointestinal site of action for MS and IMI length by GRP-27 and GRP-29, which is most likely the stomach and/or the duodenum...

Research Grants30

  1. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth H Cowan; Fiscal Year: 2013
    ....