The Center for Native and Pacific Health Disparities Research
Principal Investigator: MARJORIE K LEIMOMI MALA MAU
Abstract: DESCRIPTION (provided by applicant): This Competitive renewal application for the Center for Native and Pacific Health Disparities Research (CNPHDR or Center;P20 MD 000173) seeks 5 years of additional funding to develop a new paradigm for advancing the science of health disparities research using community engagement and empowerment to eliminate health disparities and the promotion of health equity. Our scientific theme will remain cardiometabolic health disparities among our priority populations of Native (Alaska Native, Native Hawaiians, New Zealand Maori) and Pacific Peoples (Pacific Islanders, Micronesians, Filipinos). The major focus of research investigation will include clinical, health services, interventional and translational research designs. The Center consists of 4 Cores (Research, Training and Education, Community Engagement and Administrative) and 2 Research Subprojects. Sub-project #1: Aims to examine racial/ethnic differences in the prevalence and cost of preventable hospitalizations due to heart disease and diabetes and to use this health administrative data to pilot test a hospital-based intervention to prevent re-hospitalization. Sub-Project #2: Aims to characterize the prevalence of intracerebral hemorrhage (ICH) and associated risk factors in the largest stroke center in the State. Initial results will then be used to inform a randomized contro trial to test a patient navigator program to improve prognosis and health related quality of life and post-stroke depression. The success of the overall CNPHDR hinges on the success of the individual cores to meet the OVERALL AIMS as follows: Aim#1: Design and implement health and health care disparities research studies of high impact to our priority populations. Aim#2: Build and train a diverse scientific workforce to actively participate in the health disparities research enterprise. Aim#3: Advance community engagement research approaches to strengthen participation of diverse communities in the research process and to empower communities to take action towards meaningful improvement in their own health and wellness. Aim#4: Integrate and centralize Native and Pacific Peoples health disparities research for the purpose of developing a new interdisciplinary science aimed at the elimination of health disparities and the promotion of health equity. The Center's proposal has many strengths: 1) It's organizational infrastructure is innovative in its approach to embrace community empowerment and engagement as the means to engender community participation in the research process and to build trust. 2) It's unique contribution to understanding cardiometabolic health disparities in 3 Native populations in the Pacific region. 3) Its commitment to build and train a diverse scientific workforce. 4) Its focus to synergize resources to stimulate a new paradigm of interdisciplinary health disparities science. 5) To prepare and empower our diverse Native and Pacific People communities to take ownership of their own health and wellness.
Funding Period: 2002-09-30 - 2017-10-31
more information: NIH RePORT
- Disparities among Asians and native Hawaiians and Pacific Islanders with ischemic strokeKazuma Nakagawa
Queen s Medical Center, Honolulu, HI, USA
Neurology 80:839-43. 2013..To evaluate disparities in cardiovascular risk factors among Asians and Native Hawaiians and other Pacific Islanders (NHPI) in Hawaii who are hospitalized with ischemic stroke...
- Changes in fat mitochondrial DNA and function in subjects randomized to abacavir-lamivudine or tenofovir DF-emtricitabine with atazanavir-ritonavir or efavirenz: AIDS Clinical Trials Group study A5224s, substudy of A5202Grace A McComsey
Case Western Reserve University, Cleveland, Ohio 44106, USA
J Infect Dis 207:604-11. 2013..The effect of nonthymidine nucleoside reverse-transcriptase inhibitors (NRTIs) on fat mitochondrial DNA (mtDNA) content and function is unclear...
- Rapid growth from 12 to 23 months of life predicts obesity in a population of Pacific Island childrenMay Okihiro
Department of Pediatrics, University of Hawaii John A Burns School of Medicine, 1319 Punahou St, Suite 720, Honolulu, Hawaii 96826, USA
Ethn Dis 22:439-44. 2012..Rapid growth (RG) in early childhood has been associated with increased risk of obesity. The specific intervals when risk is highest have not been well examined and may help identify modifiable risk factors...
- Phyllostachys edulis compounds inhibit palmitic acid-induced monocyte chemoattractant protein 1 (MCP-1) productionJason K Higa
Department of Cell and Molecular Biology, University of Hawaii John A Burns School of Medicine, Honolulu, Hawaii, USA
PLoS ONE 7:e45082. 2012..This study examines the effect of P. edulis extract on cellular production of MCP-1 and on the NF-κB and AP-1 pathways in response to treatment with palmitic acid (PA), a FFA...
- Factors associated with poor glycemic control or wide glycemic variability among diabetes patients in Hawaii, 2006-2009Deborah Taira Juarez
College of Pharmacy, University of Hawaii, 677 Ala Moana Blvd, Ste 1025, Honolulu, HI 96813, USA
Prev Chronic Dis 9:120065. 2012..The objective of this study was to identify factors associated with sustained poor glycemic control, some glycemic variability, and wide glycemic variability among diabetes patients over 3 years...
- Developing a culturally based cardiac rehabilitation program: the HELA studyMele A Look
University of Hawai i, School of Medicine, USA
Prog Community Health Partnersh 6:103-10. 2012..The utilization of cultural practices in health interventions can improve outcomes and increase enrollment and retention, but requires sensitivity and understanding...
- Effects of a high-fat diet and bamboo extract supplement on anxiety- and depression-like neurobehaviours in miceAdeline Del Rosario
Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, 1955 East West Road, Honolulu, HI 96822, USA
Br J Nutr 108:1143-9. 2012....
- Regulation of glucose metabolism via hepatic forkhead transcription factor 1 (FoxO1) by Morinda citrifolia (noni) in high-fat diet-induced obese micePratibha V Nerurkar
Department of Molecular Biosciences and Bioengineering MBBE, College of Tropical Agriculture and Human Resources CTAHR, University of Hawaii at Manoa, Honolulu, HI 96822, USA
Br J Nutr 108:218-28. 2012..HepG2 cells demonstrated more than 80 % inhibition of PEPCK and G6P mRNA expression in cells treated with FoxO1 siRNA and fNJ. These data suggest that fNJ improves glucose metabolism via FoxO1 regulation in HFD-fed mice...
- Depression and type 2 diabetes among Alaska Native primary care patientsDenise A Dillard
Research Department, Southcentral Foundation, Anchorage, Alaska 99508, USA
Ethn Dis 23:56-64. 2013..To assess whether type 2 diabetes mellitus (DM2) and DM2 complications are associated with presence and severity of depression among Alaska Native and American Indian people (AN/Als)...
- Implementing the obesity care model at a community health center in Hawaii to address childhood obesityMay Okihiro
Department of Pediatrics, University of Hawaii John A Burns School of Medicine, 1319 Punahou St, Honolulu, HI 96826, USA
J Health Care Poor Underserved 24:1-11. 2013..We anticipate that these efforts will contribute to the long-term goal of reducing the prevalence of obesity and obesity associated morbidity in the community...
- Interventions to increase medication adherence in African-American and Latino populations: a literature reviewDaniel Hu
University of Hawai i at Hilo Hilo, HI DH, DTJ
Hawaii J Med Public Health 73:11-8. 2014..There was a lack of congruence among studies in the way adherence was measured and reported. No single intervention has been seen to be universally successful, particularly for patients from ethnic minority backgrounds. ..
- Adjustments to diabetes medications in response to increases in hemoglobin a1c: an epidemiologic studyJames Davis
John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
Ann Pharmacother 48:41-7. 2014..A secondary objective was to measure the effect of adjustments on subsequent HbA1c levels...
- Metabolic equivalent determination in the cultural dance of hulaT Usagawa
Department of Native Hawaiian Health, University of Hawaii, Honolulu, United States
Int J Sports Med 35:399-402. 2014..This study demonstrates that the energy expenditure of both low- and high-intensity hula met the recommended guidelines for moderate and vigorous intensity exercise, respectively, and that hula can be utilized as a prescribed PA. ..
- The role of HIV and monocytes/macrophages in adipose tissue biologyCecilia M Shikuma
Departments of Medicine, Cell and Molecular Biology, Tropical Medicine, Medical Microbiology, and Pharmacology, University of Hawaii, Honolulu, HI
J Acquir Immune Defic Syndr 65:151-9. 2014..To assess the role of HIV and monocytes/macrophages in adipose tissue dysregulation...
- Using quantile regression to assess disparities in medication adherenceDeborah T Juarez
College of Pharmacy, University of Hawaii, Hilo, HI, USA
Am J Health Behav 38:53-62. 2014..To examine racial/ethnic disparities in medication adherence between Asian and Pacific Islander Americans and Whites...
- Sex differences in the use of early do-not-resuscitate orders after intracerebral hemorrhageKazuma Nakagawa
From The Queen s Medical Center, Honolulu, HI K N, M A V, T B S, M A K, S M A, C W J C Departments of Medicine K N, T B S, M A K, C W J C, Native Hawaiian Health T B S, and Surgery C W J C, John A Burns School of Medicine, University of Hawaii, Honolulu, HI and the Department of Neurology and Neurosurgery, University of California, San Francisco, CA J C H
Stroke 44:3229-31. 2013..However, the sex differences in the use of DNR orders after acute intracerebral hemorrhage (ICH) have not been described...
- Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiationTodd Hulgan
1 Vanderbilt University School of Medicine, Nashville, Tennessee
AIDS Res Hum Retroviruses 29:1293-9. 2013..These preliminary findings support the hypothesis that mtDNA variation influences metabolic ART effects. Validation studies in larger populations and in different racial/ethnic groups that include m.10398G carriers are needed...
- Comparison of potentially preventable hospitalizations related to diabetes among Native Hawaiian, Chinese, Filipino, and Japanese elderly compared with whites, Hawai'i, December 2006-December 2010Tetine L Sentell
Office of Public Health Studies, University of Hawai i at Manoa, John A Burns School of Medicine, Honolulu, HI 96822, USA
Prev Chronic Dis 10:E123. 2013..We examined racial/ethnic differences in diabetes-related potentially preventable hospitalizations (DRPH) among people aged 65 years or older for Japanese, Chinese, Filipinos, Native Hawaiians, and whites...
- Characteristics of patients with type 2 diabetes mellitus in two rural, medically underserved communitiesJocelyn Ko
University of Hawai i, Center for Native and Pacific Health Disparities Research, Department of Native Hawaiian Health, John A Burns School of Medicine, Honolulu, HI, USA
Hawaii J Med Public Health 72:191-6. 2013....
- Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): a vegetable commonly used for diabetes managementLaura S Snee
Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering MBBE, CTAHR, University of Hawaii, Honolulu, USA
Nutr J 10:78. 2011..The aim of this study was to develop bitter melon-containing recipes and test their palatability and acceptability in healthy individuals for future clinical studies...
- Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fatJason K Higa
Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street BSB 222, Honolulu, HI 96813, USA
Br J Nutr 106:1810-3. 2011..The present study suggests that the BEX supplement in the high-fat diet ameliorates elevated MCP-1 concentrations in the blood, and whether this is related to modulated endocrine properties of the visceral fat is to be studied...
- Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammationPratibha V Nerurkar
Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, HI 96822, USA
J Neuroinflammation 8:64. 2011..The objective of our study was to investigate the neuroprotective effects of Momordica charantia (bitter melon) on high-fat diet (HFD)-associated BBB disruption, stress and neuroinflammatory cytokines...
- Depletion of SK1 channel subunits leads to constitutive insulin secretionMarilou A Andres
Pacific Biosciences Research Center, University of Hawaii, 1993 East West Road, Honolulu, HI 96822, United States
FEBS Lett 583:369-76. 2009..Together, these results implicate SK1 subunits as key regulators of excitability and endocrine function in beta cells...
- Environmental factors of obesity in communities with native HawaiiansMarjorie K Mau
Department of Native Hawaiian Health, John A Bums School of Medicine, University of Hawai i, Honolulu, HI, USA
Hawaii Med J 67:233-6. 2008..To compare the fast food outlets and exercise resources across 3 communities with varying percentages of Native Hawaiians (NH) and to correlate these findings with obesity prevalence...
- Native and Pacific health disparities researchJoseph Keawe aimoku Kaholokula
Department of Native Hawaiian Health, John A Burns School of Medicine, USA
Hawaii Med J 67:218-9, 222. 2008
- Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy statusCecilia M Shikuma
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
AIDS Res Hum Retroviruses 24:1255-62. 2008..We conclude that CI and CIV levels in PBMCs correlate to their respective levels in fat and may have utility as surrogate markers of mitochondrial dysfunction in lipoatrophy...
- Making diabetes self-management education culturally relevant for Filipino Americans in HawaiiMelissa L Finucane
Center for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii, USA
Diabetes Educ 34:841-53. 2008....
- Diabetes training of community health workers serving native Hawaiians and Pacific peopleMele A Look
Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawaii, 651 Ilalo Street, MEB 307H, Honolulu, HI 96813, USA
Diabetes Educ 34:834-40. 2008..Training of community health workers (CHWs) serving Native Hawaiian and Pacific People about diabetes prevention, control, and management was identified as a priority in a needs assessment of health agencies in Hawaii...
- Endothelial function in human immunodeficiency virus-infected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152sFrancesca J Torriani
Infection Prevention and Clinical Epidemiology Unit, University of California San Diego, 200 West Arbor Drive, MC 8951, San Diego, California 92103, USA
J Am Coll Cardiol 52:569-76. 2008..This study evaluated the effects of 3 class-sparing antiretroviral therapy (ART) regimens on endothelial function in human immunodeficiency virus (HIV)-infected subjects participating in a randomized trial...
- Computing differential sample size for case-control studies of gene-environment interactionJimmy Thomas Efird
Biostatistics and Data Management Facility, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
Ethn Dis 18:S2-25-9. 2008..Sample size increases proportionately with genotype frequency for a given environment exposure odds ratio...
- A method to model season of birth as a surrogate environmental risk factor for diseaseJimmy Thomas Efird
Cancer Research Center of Hawaii, John A Burns School of Medicine, 651 Ilalo Street, Biosciences Bldg 320 B, Honolulu, HI 96813, USA
Int J Environ Res Public Health 5:49-53. 2008..Advantages of this derivative-free method include ease of use, increased statistical power to detect associations, and the ability to avoid potentially arbitrary, subjective demarcation of seasons...
- Hawai'i's role to increase public participation in health researchMarjorie K Mau
Hawaii Med J 67:4-6. 2008
- Tobacco use among Native Hawaiian middle school students: its prevalence, correlates and implicationsKaren Glanz
Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Ethn Health 12:227-44. 2007..This study also explored whether social influence, psychosocial and cultural factors are associated with cigarette use in this sample...
- Epidemiologic and clinical factors associated with chronic kidney disease among Asian Americans and Native HawaiiansMarjorie K Mau
Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai i at Manoa, Honolulu, HI 96813, USA
Ethn Health 12:111-27. 2007....
- Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infectionV Valcour
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
HIV Med 10:103-10. 2009..We present an open-label single-arm pilot study to evaluate changes in intra-epidermal nerve fibre (IENF) density and mitochondrial DNA (mtDNA) copies/cell among subjects treated with 3000 mg ALC daily...
- Diabetes prevalence and body mass index differ by ethnicity: the Multiethnic CohortGertraud Maskarinec
Cancer Research Center of Hawaii, 1236 Lauhala St, Honolulu, HI 96813, USA
Ethn Dis 19:49-55. 2009..The objectives of this study were to estimate the prevalence of diabetes among participants of the Multiethnic Cohort (MEC) and to examine the association of body mass index (BMI) with self-reported diabetes by ethnicity...
- Risk factors associated with methamphetamine use and heart failure among native Hawaiians and other Pacific Island peoplesMarjorie K Mau
Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai i at Manoa, USA
Vasc Health Risk Manag 5:45-52. 2009..Data were analyzed by odds ratios (OR), 95% confidence intervals (CI), and multiple logistic regression analysis...
- Bamboo extract reduces interleukin 6 (IL-6) overproduction under lipotoxic conditions through inhibiting the activation of NF-κB and AP-1 pathwaysJason K Higa
Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street BSB 222, Honolulu, HI 96813, USA
Cytokine 55:18-23. 2011....
- Association between perceived racism and physiological stress indices in Native HawaiiansJoseph Keawe aimoku Kaholokula
Department of Native Hawaiian Health, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA
J Behav Med 35:27-37. 2012..Racism appears to be a chronic stressor that can "get under the skin" of Native Hawaiians by affecting their physical health and risk for stress-related diseases, possibly, through mechanisms of cortisol dysregulation...
- Quality assessment of human mitochondrial DNA quantification: MITONAUTS, an international multicentre surveyHelene C F Cote
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
Mitochondrion 11:520-7. 2011..However, within laboratory and relative mtDNA/nDNA comparisons between laboratories should be reliable...
- Diabetes bingo: research prioritization with the Filipino communityAnne R Leake
School of Nursing and Dental Hygiene, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
Hawaii Med J 69:237-41. 2010..The multi-voting technique was readily accepted and enjoyed by participants...
- Mortality patterns of Native Hawaiians across their lifespan: 1990-2000Sela V Panapasa
Institute for Social Research, University of Michigan, Ann Arbor, MI 48106, USA
Am J Public Health 100:2304-10. 2010..We examined mortality patterns across the lifespan of Native Hawaiians and compared mortality disparities across races...
- The effect of bamboo extract on hepatic biotransforming enzymes--findings from an obese-diabetic mouse modelCheryl L K Koide
Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
J Ethnopharmacol 133:37-45. 2011....
- Diabetes care in a predominantly Native Hawaiian and Pacific Islander outpatient populationRachel Lee
Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
Hawaii Med J 69:28-30. 2010....
- Detecting cardiometabolic syndrome using World Health Organization public health action points for Asians and Pacific IslandersAndrew Grandinetti
University of Hawai i at Manoa, John A Burns School of Medicine, Department of Public Health Sciences, Honolulu, HI 96822, USA
Ethn Dis 20:123-8. 2010..To assess the screening characteristics of World Health Organization (WHO) body mass index action points for cardiometabolic syndrome (CMS) in Native Hawaiians and people of Asian ancestry (ie, Filipino and Japanese)...
- All-cause and CVD mortality in Native HawaiiansN Emmett Aluli
Moloka i General Hospital, Kaunakakai, Moloka i, HI, USA
Diabetes Res Clin Pract 89:65-71. 2010..Cardiovascular disease (CVD) is the leading cause of death among Native Hawaiians. In this article, all-cause and cardiovascular mortality rates among Native Hawaiians are examined, along with associated CVD risk factors...
- Translating diabetes prevention into native Hawaiian and Pacific Islander communities: the PILI 'Ohana Pilot projectMarjorie K Mau
University of Hawai i, Center for Native and Pacific Health Disparities Research, Department of Native Hawaiian Health, John A Burns School of Medicine
Prog Community Health Partnersh 4:7-16. 2010..Community-based participatory research (CBPR) is an approach that engages the community in the research process and has recently been proposed as a means to improve the translation of research into community practice...
- Diabetes and cardiovascular risk factors in Native HawaiiansN Emmett Aluli
Moloka i General Hospital, Kaunakakai, HI 96748, USA
Hawaii Med J 68:152-7. 2009..Diabetes is a risk factor for cardiovascular disease (CVD), the leading cause of death among Native Hawaiians. In this article, the prevalence of diabetes is reported and associations with CVD risk factors are examined...
- Cardiometabolic health disparities in native Hawaiians and other Pacific IslandersMarjorie K Mau
Center for Native and Pacific Health Disparities Research, Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai i at Manoa, Honolulu, HI 96813, USA
Epidemiol Rev 31:113-29. 2009..More experimental intervention studies are needed to examine promising approaches to reversing the rising tide of cardiometabolic health disparities in NHOPI...
- Ethnic differences in perinatal outcome of gestational diabetes mellitusJana Kaida Silva
Native Hawaiian Health, John A Burns School of Medicine, University of Hawai i, 677 Ala Moana Blvd, Suite 1016B, Honolulu, HI 96813, USA
Diabetes Care 29:2058-63. 2006..S., little is known about the risk for adverse perinatal outcomes in these populations. We sought to examine ethnic differences in perinatal outcome among Asian and Pacific-Islander women with GDM...