UNMC EPPLEY CANCER CENTER SUPPORT GRANT

Summary

Principal Investigator: Kenneth H Cowan
Abstract: DESCRIPTION (provided by applicant): The UNMC Eppley Cancer Center is an NCI-designated matrix Cancer Center at the University of Nebraska Medical Center (UNMC) conducting a wide range of basic, clinical, translational and population science research. The Cancer Center Director reports directly to the Chancellor of UNMC, and also serves as Director of the Eppley Institute for Cancer Research, a multidisciplinary cancer research unit. NCI-defined peer-reviewed funding for the Cancer Center is currently over $40 M (annual direct costs), a 1.25 fold increase since 2004. In addition, NCI funding for the Cancer Center increased nearly $6 M (direct costs) since the last review and now accounts for almost 40% of peer-reviewed funding in the Cancer Center. The Cancer Center has been in a dynamic growth phase with recruitment of 39 members since the last review. The Cancer Center continues to enjoy outstanding support from the state of Nebraska. Over the past five years, the Cancer Center has received almost $43 M in state and institutional support and over $12 M in philanthropic support. State support provided resources for new facilities, faculty recruitment and enhanced shared resources, including the construction of a $20 M Cellular Good Manufacturing Practices (cGMP) facility and establishment of a high-throughput Genome-wide RNAi Screening Facility. The opening of the $76 M Durham Research Center II (DRC II) in 2009, the ECC was assigned 2 floors (64,000 gsf) of additional research space and now has a total of 270,000 gsf of laboratory space under the authority of the Director. A new multidisciplinary Cancer Clinic was opened in west Omaha in 2008, providing 60,000 gsf of new clinic and treatment facilities. Since the last review, 26 clinical faculty were recruited and the Cancer Center signed Affiliation Agreements with four hospitals across the state providing expanded access to Cancer Center clinical trials. The Cancer Center has three translationally oriented research programs: 1) Cancer Genes and Molecular Regulation;2) Molecular and Biochemical Etiology of Cancer;and 3) Lymphoma Research Program and a developing program in Cancer Control and Prevention. Translational research is also facilitated through disease-oriented research working groups including breast cancer, prostate cancer, and pancreatic cancer. The Cancer Center also supports ten shared resources: Bioinformatics, Biostatistics, Cell Analysis, Centralized Protocol Data Management Unit, Confocal Microscopy, Laboratory Support, Molecular Biology, Monoclonal Antibody, Pathology, and Structural Biology.
Funding Period: 1997-09-05 - 2016-07-31
more information: NIH RePORT

Top Publications

  1. pmc Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis
    Eugenie Carletti
    Laboratoire de Biophysique Moléculaire, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France
    Chem Res Toxicol 24:797-808. 2011
  2. pmc Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA
    Nigar D Babayeva
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA
    Cell Cycle 9:3054-62. 2010
  3. ncbi Tumor-stromal interactions in bone metastasis
    Kalyan C Nannuru
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE, 68198 5900, USA
    Curr Osteoporos Rep 8:105-13. 2010
  4. pmc Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response
    Y Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    Oncogene 29:4317-29. 2010
  5. pmc Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway
    S Senapati
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Oncogene 29:1293-302. 2010
  6. pmc Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose
    Bin Li
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    J Appl Toxicol 30:559-65. 2010
  7. pmc Crystal structure of HIV-1 Tat complexed with human P-TEFb
    Tahir H Tahirov
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Nature 465:747-51. 2010
  8. pmc Cathepsin G-mediated enhanced TGF-beta signaling promotes angiogenesis via upregulation of VEGF and MCP-1
    Thomas J Wilson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198 5845, United States
    Cancer Lett 288:162-9. 2010
  9. pmc Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture
    Lei Duan
    Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 285:1555-68. 2010
  10. pmc Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion
    Seema Singh
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198 5900, USA
    Int J Cancer 126:328-36. 2010

Detail Information

Publications282 found, 100 shown here

  1. pmc Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis
    Eugenie Carletti
    Laboratoire de Biophysique Moléculaire, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France
    Chem Res Toxicol 24:797-808. 2011
    ..The crystal structure of CBDP-inhibited BChE confirmed that the phosphate adduct is the ultimate aging product. CBDP is the first organophosphorus agent that leads to a fully dealkylated phospho-serine BChE adduct...
  2. pmc Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA
    Nigar D Babayeva
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA
    Cell Cycle 9:3054-62. 2010
    ..The proposed mechanism was verified both in vitro by surface plasmon resonance and in vivo by transcription-based assays...
  3. ncbi Tumor-stromal interactions in bone metastasis
    Kalyan C Nannuru
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE, 68198 5900, USA
    Curr Osteoporos Rep 8:105-13. 2010
    ..In this article, we review the important mechanisms of tumor-stromal interaction in the development of bone metastasis...
  4. pmc Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response
    Y Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    Oncogene 29:4317-29. 2010
    ..These results suggest an important regulation of PP2A on IR-induced G2/M checkpoint signaling response...
  5. pmc Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway
    S Senapati
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Oncogene 29:1293-302. 2010
    ..Activation of the FAK-RhoA signaling pathway is involved in MIC-1-mediated actin reorganization, and thus, leads to an increase in the motility of prostate cancer cells...
  6. pmc Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose
    Bin Li
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    J Appl Toxicol 30:559-65. 2010
    ..In conclusion, a mass spectrometry method for identification of exposure to live toxic pesticides has been developed, based on identification of pesticide adducts on the active site serine of human butyrylcholinesterase...
  7. pmc Crystal structure of HIV-1 Tat complexed with human P-TEFb
    Tahir H Tahirov
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Nature 465:747-51. 2010
    ..Importantly, Tat induces significant conformational changes in P-TEFb. This finding lays a foundation for the design of compounds that would specifically inhibit the Tat.P-TEFb complex and block HIV replication...
  8. pmc Cathepsin G-mediated enhanced TGF-beta signaling promotes angiogenesis via upregulation of VEGF and MCP-1
    Thomas J Wilson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198 5845, United States
    Cancer Lett 288:162-9. 2010
    ..Cathepsin G upregulation at the tumor-bone interface has been linked to increased TGF-beta signaling, and we also report that inhibition of Cathepsin G reduced tumor vascularity, as well as VEGF and MCP-1 expression...
  9. pmc Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture
    Lei Duan
    Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 285:1555-68. 2010
    ..These results indicate that RhoA plays an antagonistic role to Rac1/Cdc42 in the control of mammary epithelial acinar morphogenesis...
  10. pmc Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion
    Seema Singh
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198 5900, USA
    Int J Cancer 126:328-36. 2010
    ....
  11. pmc Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents
    Wei Jiang
    Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950, USA
    Toxicol Sci 115:183-93. 2010
    ..Covalent binding of CPO to tubulin and to tubulin-associated proteins is a potential mechanism of neurotoxicity...
  12. pmc AACR centennial series: the biology of cancer metastasis: historical perspective
    James E Talmadge
    The University of Nebraska Medical Center, Transplantation Immunology Laboratory, Omaha, Nebraska, USA
    Cancer Res 70:5649-69. 2010
    ....
  13. pmc Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells
    Mayumi Naramura
    Eppley Institute for Research in Cancer and Allied Diseases and Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Proc Natl Acad Sci U S A 107:16274-9. 2010
    ..Thus, Cbl and Cbl-b play redundant but essential roles in HSC regulation, whose breakdown leads to hematological abnormalities that phenocopy crucial aspects of mutant Cbl-driven human myeloid malignancies...
  14. pmc Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 48:318-24. 2010
    ..Reaction of catechol quinones of natural and synthetic estrogens, benzene, naphthalene, and dopamine with DNA to form depurinating adducts is a common feature that may lead to initiation of cancer or neurodegenerative disease...
  15. pmc Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system
    Andrea Gaydess
    College of Pharmacy and Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198 5830, United States
    Chem Biol Interact 187:295-8. 2010
    ..Activity assays showed that BChE remained active in the brain at 72-h post-injection. It was concluded that nanocomplexes can deliver the 340 kDa BChE tetramer to the brain...
  16. pmc Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates
    Lawrence M Schopfer
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1297-311. 2010
    ..Modified peptides are difficult to find when the OP bears no radiolabel and no tag. The characteristic MSMS fragment ions are valuable because they are identifiers for OP-tyrosine, independent of the peptide...
  17. pmc Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos
    Bin Li
    Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950, USA
    Toxicol Sci 116:23-31. 2010
    ..Identification of other OP-modified proteins may lead to an understanding of neurotoxic symptoms that appear long after the initial OP exposure...
  18. pmc Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545
    Mariya S Liyasova
    University of Nebraska Medical Center, Department of Environmental, Agricultural and Occupational Health, Omaha, NE 68198 6805, USA
    Biochem Pharmacol 79:784-91. 2010
    ..It was concluded that the aspirin esterase activity of albumin is a pseudo-esterase activity in which aspirin stably acetylates lysines and releases salicylate...
  19. pmc Quantitative analysis of glycation sites on human serum albumin using (16)O/(18)O-labeling and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Omar S Barnaby
    Department of Chemistry, University of Nebraska, Lincoln, NE, United States
    Clin Chim Acta 411:1102-10. 2010
    ....
  20. pmc Pathobiological implications of MUC16 expression in pancreatic cancer
    Dhanya Haridas
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e26839. 2011
    ..Altogether, our results reveal that MUC16 expression is significantly increased in PC and could play a potential role in the progression of this disease...
  21. pmc Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
    Srikumar M Raja
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, IL, USA
    Cancer Biol Ther 11:263-76. 2011
    ..These studies suggest the potential use of Michael acceptor-containing molecules as novel therapeutic modalities against ErbB2-driven breast cancer by targeting multiple biological attributes of the driver oncogene...
  22. ncbi Spirituality, patients' worry, and follow-up health-care utilization among cancer survivors
    Anthony J Cannon
    Department of Internal Medicine, Section of Oncology Hematology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7689, USA
    J Support Oncol 9:141-8. 2011
    ..Spirituality may aid cancer survivors as they attempt to interpret the meaning of their experience...
  23. pmc Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2
    Haley L Peters
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Immunol Res 51:39-44. 2011
    ..This review focuses on this recently revealed function of APLP2 relevant to tumor immunology: that it acts as a novel regulator of MHC class I molecule surface expression...
  24. pmc Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab
    Paul N Meyer
    University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Clin Oncol 29:200-7. 2011
    ..Various immunohistochemical algorithms have been developed to replicate these microarray results and/or stratify patients according to survival. This study compares some of those algorithms and also proposes some modifications...
  25. pmc A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling
    Anguraj Sadanandam
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5900, USA
    BMC Cancer 11:304. 2011
    ..Analysis of tumors from this model revealed that they exhibited strong bone resorption, induction of osteoclasts and intracranial penetration at the tumor bone (TB)-interface...
  26. pmc Virtual CGH: an integrative approach to predict genetic abnormalities from gene expression microarray data applied in lymphoma
    Huimin Geng
    Department of Computer Science, University of Nebraska at Omaha, Omaha, NE 68182, USA
    BMC Med Genomics 4:32. 2011
    ..In addition, the CNAs identified by GEP would be more functionally relevant CNAs in the disease pathogenesis since the functional effects of CNAs can be reflected by altered gene expression...
  27. pmc Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases
    Michelle L Varney
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, USA
    Cancer Lett 300:180-8. 2011
    ..These studies demonstrate the important role of CXCR2/1 in colon cancer metastasis and that inhibition of CXCR2 and CXCR1, small molecule antagonists provides a novel therapeutic strategy...
  28. pmc Crystal structure of the C-terminal domain of human DNA primase large subunit: implications for the mechanism of the primase-polymerase α switch
    Vinod B Agarkar
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    Cell Cycle 10:926-31. 2011
    ....
  29. pmc Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA
    Artem G Lada
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e24848. 2011
    ....
  30. pmc Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer
    Dali Huang
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, USA
    Int J Cancer 126:315-27. 2010
    ....
  31. pmc High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis
    Anguraj Sadanandam
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5900, USA
    Int J Cancer 127:1373-83. 2010
    ..Together, these data demonstrate that the expression of SEMA5A in pancreatic cancer cells regulates tumorigenesis, growth, invasion and metastasis, and it also suggests a novel target for diagnosis and treatment of pancreatic cancer...
  32. pmc Development of diagnostics in the search for an explanation of aerotoxic syndrome
    Lawrence M Schopfer
    Eppley Institute, University of Nebraska Medical Center, Omaha, 68198, USA
    Anal Biochem 404:64-74. 2010
    ..It is concluded that toxic gases or oil mists in cabin air may form adducts on plasma butyrylcholinesterase and albumin, detectable by mass spectrometry...
  33. pmc Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface
    Kalyan C Nannuru
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5900, USA
    Cancer Res 70:3494-504. 2010
    ..Together, our data indicate that upregulation of MMP13 at the TB interface is important in tumor-induced osteolysis and suggest that MMP13 is a potential therapeutic target for breast cancer bone metastasis...
  34. pmc Stimulating progress in regenerative medicine: improving the cloning and recovery of cryopreserved human pluripotent stem cells with ROCK inhibitors
    Angie Rizzino
    Eppley Institute for Research in Cancer and Allied Diseases and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Regen Med 5:799-807. 2010
    ....
  35. pmc Effect of a tapasin mutant on the assembly of the mouse MHC class I molecule H2-K(d)
    Laura C Simone
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    Immunol Cell Biol 88:57-62. 2010
    ....
  36. ncbi Association of number of follow-up providers with outcomes in survivors of hematologic malignancies
    Anthony J Cannon
    Section of Oncology Hematology, Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Leuk Lymphoma 51:1862-9. 2010
    ..48, p = 0.44) after adjusting for patient factors. Our study showed that among survivors of hematologic malignancies, outcomes were not different for survivors who were seen by single or multiple follow-up providers...
  37. pmc Influence of the tapasin C terminus on the assembly of MHC class I allotypes
    Laura C Simone
    Eppley Institute for Research in Cancer and Allied Diseases and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Immunogenetics 61:43-54. 2009
    ..Our findings indicate that the C terminus of mouse tapasin plays a vital role in enabling murine MHC class I molecules to be expressed at the surface of mouse cells...
  38. pmc Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis
    Seema Singh
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5845, USA
    Cancer Res 69:411-5. 2009
    ..Together, these studies show the importance of host CXCR2-dependent CXCL-8-mediated angiogenesis in the regulation of melanoma growth and metastasis...
  39. pmc Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: visualization and quantification of enzyme distribution in the brain
    Noel D Johnson
    Division of Comparative Medicine, University of Nebraska Medical Center, Omaha, NE 68198, United States
    Neurotoxicology 30:386-92. 2009
    ..This procedure proved to be an efficient, safe and rapid method to deliver BChE to the CNS of mice, providing a research tool for determining neural protection by BChE following OP exposure...
  40. pmc Mass spectrometry identifies multiple organophosphorylated sites on tubulin
    Hasmik Grigoryan
    University of Nebraska Medical Center, Eppley Institute for Cancer Research, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Toxicol Appl Pharmacol 240:149-58. 2009
    ..In conclusion seventeen tyrosines in tubulin have the potential to covalently bind chlorpyrifos oxon. These results will be useful when searching for OP-labeled tubulin in live animals...
  41. pmc Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains
    Denis Bouvier
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 284:34257-71. 2009
    ....
  42. ncbi Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras
    Phillip J Wilder
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68198 6805, USA
    Biochem Biophys Res Commun 381:706-11. 2009
    ..These findings support the hypothesis that the Ras/Raf/Mek/Erk pathway may be constitutively active even in pancreatic tumor cells that express wild-type K-ras...
  43. pmc Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity
    Hasmik Grigoryan
    University of Nebraska Medical Center, Eppley Institute for Cancer Research, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Toxicol Appl Pharmacol 240:143-8. 2009
    ..In conclusion, chlorpyrifos oxon binding to tubulin disrupts tubulin polymerization. These results may lead to an understanding of the neurotoxicity of organophosphorus agents...
  44. pmc Comparative analysis of the impact of a free cysteine in tapasin on the maturation and surface expression of murine MHC class I allotypes
    X Wang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Int J Immunogenet 36:183-7. 2009
    ....
  45. ncbi Lymphangiogenesis and anti-tumor immune responses
    Michelle L Varney
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5845, USA
    Curr Mol Med 9:694-701. 2009
    ....
  46. pmc Elevated expression of L-selectin ligand in lymph node-derived human prostate cancer cells correlates with increased tumorigenicity
    Prakash Radhakrishnan
    Department of Biochemistry and Molecular Biology, College of Medicine, 985870, Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Glycoconj J 26:75-81. 2009
    ..These results suggest that modulated expression of selective glycogenes correlates with altered tumorigenicity of cancer cells...
  47. ncbi Detection of chromosomal aberrations in renal tumors: a comparative study of conventional cytogenetics and virtual karyotyping with single-nucleotide polymorphism microarrays
    Federico A Monzon
    Department of Pathology, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, Texas 77030, USA
    Arch Pathol Lab Med 133:1917-22. 2009
    ....
  48. pmc Protein-protein interactions of tandem affinity purified protein kinases from rice
    Jai S Rohila
    Plant Science Initiative, University of Nebraska, Lincoln, NE, USA
    PLoS ONE 4:e6685. 2009
    ....
  49. pmc Survival disparities in patients with lymphoma according to place of residence and treatment provider: a population-based study
    Fausto R Loberiza
    Section of Oncology Hematology, Summer Undergraduate Research Program, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 7680, USA
    J Clin Oncol 27:5376-82. 2009
    ....
  50. pmc Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA
    Vinod B Agarkar
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:1261-3. 2009
    ..The crystals belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 42.66, b = 52, c = 99.78 A, and diffracted to a resolution of 2.2 A...
  51. pmc Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma
    Taketoshi Yasuda
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Mod Pathol 22:1499-506. 2009
    ..The latter could potentially be utilized as an adjunct in diagnostically challenging cases...
  52. ncbi A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy
    William W L Choi
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Clin Cancer Res 15:5494-502. 2009
    ..Since then, new antibodies specific to germinal center B-cells have been developed, which might improve the performance of an immunostain algorithm...
  53. pmc Mass spectral characterization of organophosphate-labeled lysine in peptides
    Hasmik Grigoryan
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Anal Biochem 394:92-100. 2009
    ..0, 181.2, and 83.8amu. This new OP-binding motif to lysine suggests new directions to search for mechanisms of long-term effects of OP exposure and in the search for biomarkers of OP exposure...
  54. pmc Regulation of the Nanog gene by both positive and negative cis-regulatory elements in embryonal carcinoma cells and embryonic stem cells
    Brian Boer
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Mol Reprod Dev 76:173-82. 2009
    ....
  55. pmc Optimizing the solution conditions to solve the structure of the Connexin43 carboxyl terminus attached to the 4(th) transmembrane domain in detergent micelles
    Rosslyn Grosely
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Cell Commun Adhes 17:23-33. 2010
    ..Additionally, the optimal solution conditions for solving the NMR solution structure include 10% 2,2,2 trifluoroethanol and removal of the 2nd extracellular loop (G178-V196)...
  56. ncbi Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Future Oncol 6:75-91. 2010
    ..Two antioxidants, N-acetylcysteine and resveratrol, are prime candidates to prevent breast and other human cancers because in various M in vitro and in vivo experiments, they reduce the formation of estrogen-DNA adducts...
  57. pmc Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 115:1026-36. 2010
    ..Oncogenic pathways and tumor-host interactions also were identified, and these findings may lead to better therapies and outcome in the future...
  58. pmc Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA
    Vinod B Agarkar
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Mol Biol 397:278-89. 2010
    ..In this study, we determined that Elf3 amino acid residues within this flanking region, including Trp361, are important for the structural integrity of the protein as well as for the Efl3 DNA binding and transactivation activity...
  59. pmc N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 49:392-400. 2010
    ..This finding suggests that NAcCys, a common dietary supplement, could be used as a potential chemopreventive agent to block the initial step in the genotoxicity caused by catechol estrogen quinones...
  60. pmc Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior
    Patrick Masson
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Arch Biochem Biophys 494:107-20. 2010
    ..It is proposed, but not yet proven, that low dose exposure involves OP modification of proteins that have no active site serine...
  61. pmc Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine
    Oksana Lockridge
    Eppley Institute, 985950 University of Nebraska Medical Center, Omaha, NE 68198 5950, United States
    Chem Biol Interact 187:344-8. 2010
    ..Treatment of neurodegenerative disorders could be developed by identifying methods to reverse OP binding to tyrosine...
  62. pmc Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry
    Ozden Tacal
    Department of Biochemistry, School of Pharmacy, University of Hacettepe 06100 Ankara, Turkey
    J Appl Toxicol 30:469-75. 2010
    ..MSMS spectra confirmed that each of the pesticides studied made a covalent bond with serine 198 of butyrylcholinesterase. These results can be used to identify the class of pesticides to which a patient was exposed...
  63. pmc C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma
    Dali Huang
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Genes Chromosomes Cancer 49:810-8. 2010
    ..The FISH and RT-PCR assays developed in this study can serve as diagnostic adjuncts for the identification of this novel C11orf95-MKL2 fusion oncogene in chondroid lipoma...
  64. pmc Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations
    Xiao Ming Wang
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Cell Biochem 109:818-27. 2010
    ..Furthermore, we propose that similar to de novo genetic mutations, the majority of de novo DNA methylation events observed in tumors are passengers not causally involved in tumorigenesis...
  65. pmc A transmembrane tail: interaction of tapasin with TAP and the MHC class I molecule
    Laura C Simone
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mol Immunol 46:2147-50. 2009
    ..Here we summarize our current understanding of functions involving the tapasin TMD and propose that, beyond stabilizing TAP, the tapasin TMD may also interact with the MHC class I heavy chain...
  66. ncbi Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation
    Mitsuru Futakuchi
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5845, USA
    Cancer Sci 100:71-81. 2009
    ..Together, these studies demonstrate that inhibition of TGF-betaRI signaling at the TB interface will be a therapeutic target in the treatment of breast cancer-induced osteolysis...
  67. pmc CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion
    S Singh
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5845, USA
    Br J Cancer 100:1638-46. 2009
    ..Together, these studies demonstrate that CXCR1 and CXCR2 play essential role in growth, survival, motility and invasion of human melanoma...
  68. pmc Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine
    Bin Li
    Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Toxicol Sci 107:144-55. 2009
    ..The extent to which tyrosine modification by OP can occur in vivo and the toxicological implications of such modifications require further investigation...
  69. pmc Mechanism of metabolic activation and DNA adduct formation by the human carcinogen diethylstilbestrol: the defining link to natural estrogens
    Muhammad Saeed
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Int J Cancer 124:1276-84. 2009
    ....
  70. pmc Novel biomarkers for risk of prostate cancer: results from a case-control study
    Li Yang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Prostate 69:41-8. 2009
    ..The goal of this case-control study was to detect and identify potential biomarkers of Pca...
  71. pmc Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
    Jinxuan Hou
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105, USA
    J Transl Med 9:64. 2011
    ..In this study, we investigated the role of c-Met in rhabdomyosarcoma (RMS) using its small molecule inhibitor SU11274, which has been hypothesized to be a potential therapeutic target for RMS...
  72. pmc Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness
    Mohammad Saeid Jami
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    BMC Cancer 14:194. 2014
    ..In the present study, we examined the functional significance of KIAA1199 expression in breast cancer growth, motility and invasiveness...
  73. pmc Protein tyrosine adduct in humans self-poisoned by chlorpyrifos
    Bin Li
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 5950 USA
    Toxicol Appl Pharmacol 269:215-25. 2013
    ..In conclusion, chlorpyrifos oxon makes a stable covalent adduct on the tyrosine residue of blood proteins in humans who ingested chlorpyrifos...
  74. ncbi Pharmacologic inhibition of epigenetic modification reveals targets of aberrant promoter methylation in Ewing sarcoma
    Shawnagay Nestheide
    Faculty of Medicine, Division of Bone Marrow Transplantation and Immune Deficiency, Blood and Cancer Research Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Pediatr Blood Cancer 60:1437-46. 2013
    ..Although genetic changes in ES have been extensively researched, our understanding of the role of epigenetic modifications in this neoplasm is limited...
  75. pmc Agonist-induced down-regulation of endogenous protein kinase c α through an endolysosomal mechanism
    Michelle A Lum
    The Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950, USA
    J Biol Chem 288:13093-109. 2013
    ..These studies define a novel and widespread mechanism of desensitization of PKCα signaling that involves endocytic trafficking and lysosome-mediated degradation of the mature, fully phosphorylated protein...
  76. pmc Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond
    Wei Jiang
    Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950, USA
    Toxicol Sci 132:390-8. 2013
    ..BChE inhibited by authentic, racemic tabun yielded both 902.2 and 874.2 m/z peptides, indicating that both stereoisomers reacted with BChE and aged either by deamination or dealkylation...
  77. pmc Targeting CXCR2 enhances chemotherapeutic response, inhibits mammary tumor growth, angiogenesis, and lung metastasis
    Bhawna Sharma
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Cancer Ther 12:799-808. 2013
    ..Our data suggest the novel role of CXCR2 and its ligands in maintaining chemotherapy resistance and provide evidence that targeting CXCR2 signaling in an adjuvant setting will help circumvent chemotherapy resistance...
  78. pmc Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase
    Kevser Biberoglu
    Department of Biochemistry, Hacettepe University, Ankara, Turkey
    Biochim Biophys Acta 1834:745-53. 2013
    ..To date, AChE and BChE are the only proteins known that include polyproline tetramer organizing peptides in their tetrameric structure...
  79. pmc Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer
    Stephanie K Bunt
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Cancer Immunol Immunother 62:225-36. 2013
    ....
  80. ncbi Cellular immunotherapy study of prostate cancer patients and resulting IgG responses to peptide epitopes predicted from prostate tumor-associated autoantigens
    George P Hemstreet
    Department of Urology, University of Nebraska Medical Center, Omaha, NE, USA
    J Immunother 36:57-65. 2013
    ..HAP represents a viable immunotherapy approach to induce immune responses against tumor cells and may provide clinical benefit with minimal toxicity...
  81. pmc Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase
    Mariya S Liyasova
    Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Chem Biol Interact 203:103-7. 2013
    ..Nevertheless, the nitrogen of the imidazole ring of free L-histidine formed a variety of adducts upon reaction with CBDP, including the o-hydroxybenzyl adduct, suggesting that histidine-CBDP adducts may form on other proteins...
  82. pmc Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5
    Beverly S Schaffer
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Prev Res (Phila) 6:59-69. 2013
    ..Cancer Prev Res; 6(1); 59-69. ©2012 AACR...
  83. pmc Genomic imbalances in benign metastasizing leiomyoma: characterization by conventional karyotypic, fluorescence in situ hybridization, and whole genome SNP array analysis
    Joslin M Bowen
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, USA
    Cancer Genet 205:249-54. 2012
    ..These findings suggest that both the deep soft tissue and pleuropulmonary lesions were derived from the same abnormal clone and are genetically related to uterine leiomyomata...
  84. ncbi Structural basis for profilin-mediated actin nucleotide exchange
    Jason C Porta
    Department of Biochemistry and Molecular Biology, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Mol Biol 418:103-16. 2012
    ..Reversal of the solvent exposure of Trp356 is also involved in cleft closure. In addition, secondary calcium binding sites were identified...
  85. pmc Analysis of major histocompatibility complex class I folding: novel insights into intermediate forms
    L C Simone
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Tissue Antigens 79:249-62. 2012
    ..Moreover, we show that an L(d) -specific peptide induced folding of the 34-1-2(+) L(d) intermediate. Altogether, these results yield novel insights into the nature of MHC class I molecules recognized by the 34-1-2 antibody...
  86. pmc Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells
    Haley L Peters
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Int J Oncol 41:1464-74. 2012
    ..Chiefly, our discoveries establish a role for APLP2 in the growth of pancreatic cancer cells and show that inhibitors preventing APLP2 cleavage reduce the viability of pancreatic cancer cells...
  87. pmc Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation
    A Sadanandam
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198 5900, USA
    Br J Cancer 107:501-7. 2012
    ....
  88. ncbi CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma
    Zdravko Mitrovic
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Br J Haematol 162:87-92. 2013
    ..The dismal outcome of CD43(+) cases in the non-GCB subgroup may be explained, at least in part, by a less favourable microenvironment...
  89. pmc The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides
    Eric A Kumar
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68022, United States
    Sci Rep 3:1639. 2013
    ..These results point to conformational flexibility at the interface, which have implications in the design of potent Cbl(TKB)-binding peptides...
  90. ncbi Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase
    Wei Jiang
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Anal Biochem 439:132-41. 2013
    ..0 buffer, the adducts were still detectable. It was concluded that TiO2 microcolumns can be used to enrich aged OP-modified BChE peptide...
  91. pmc Unbalanced estrogen metabolism in ovarian cancer
    Muhammad Zahid
    Department of Environmental Agricultural and Occupational Health College of Public Health, University of Nebraska Medical Center, Omaha, NE
    Int J Cancer 134:2414-23. 2014
    ..These findings indicate that estrogen metabolism is unbalanced in ovarian cancer and suggest that formation of estrogen-DNA adducts plays a critical role in the initiation of ovarian cancer. ..
  92. pmc Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis
    Xiang Liu
    Authors Affiliations Eppley Institute for Research in Cancer and Allied Disease Department of Oral Biology, University of Nebraska Medical Center, Omaha, Nebraska Department of Gynecologic Oncology and Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas and Department of Translational Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California
    Cancer Res 74:1609-20. 2014
    ..The results provide new insight into the dynamic interplay between cell adhesion and motility and the relationship of these to the metastatic process...
  93. pmc The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, 984388 Nebraska Medical Center, Omaha, NE 68198 4388, USA Electronic address
    Mol Aspects Med 36:1-55. 2014
    ..Therefore, resveratrol and N-acetylcysteine provide a widely applicable, inexpensive approach to preventing many of the prevalent types of human cancer. ..
  94. pmc Characterization of the connexin45 carboxyl-terminal domain structure and interactions with molecular partners
    Jennifer L Kopanic
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska
    Biophys J 106:2184-95. 2014
    ..This domain has similarities with other cardiac connexins, and we propose they constitute a master regulatory domain, which contains overlapping molecular partner binding, cis-trans proline isomerization, and phosphorylation sites...
  95. pmc Crystallization and preliminary X-ray diffraction analysis of human DNA primase
    Andrey G Baranovskiy
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Acta Crystallogr F Struct Biol Commun 70:206-10. 2014
    ..2, b = 88.9, c = 94.68 Å, α = 93.82, β = 96.57, γ = 111.72°, and contained two heterodimers of full-length p49 and p59 subunits in the asymmetric unit...
  96. pmc PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin
    Wei Jiang
    Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950, United States
    Chem Res Toxicol 26:1917-25. 2013
    ..43 μL of plasma. Enrichment of OP-modified albumin peptides by binding to Fe(3+) beads is a method with potential application to diagnosis of OP pesticide and nerve agent exposure in humans, mice, and guinea pigs. ..
  97. pmc ITPA (inosine triphosphate pyrophosphatase): from surveillance of nucleotide pools to human disease and pharmacogenetics
    Peter D Simone
    The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mutat Res 753:131-46. 2013
    ..The Pro32Thr allele is thought to cause the observed dominant negative effect because the resulting active enzyme monomer targets both homo- and heterodimers to degradation. ..
  98. pmc MUC1 regulates expression of multiple microRNAs involved in pancreatic tumor progression, including the miR-200c/141 cluster
    Ashley M Mohr
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 8:e73306. 2013
    ..These data indicate that signaling through MUC1 influences cancer progression by regulating transcription of microRNAs that are associated with the process of metastasis. ..
  99. pmc The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core
    Peter D Simone
    The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Struct Biol 182:197-208. 2013
    ..We propose that the dimer of P32T variant subunit with wild-type subunit is degraded in cells similarly to the P32T homodimer explaining the level of loss of ITPA activity in heterozygotes...
  100. pmc Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways
    Yu Wei Chou
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    PLoS ONE 8:e61934. 2013
    ..These results can lead to advanced PCa therapy via up-regulating the degradation pathways of Cdc25C protein...
  101. pmc Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C
    Michelle A Lum
    From The Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950
    J Biol Chem 288:27112-27. 2013
    ....