Puerto Rico Testsite for Exploring Contamination Threats (PRoTECT)

Summary

Principal Investigator: Akram N Alshawabkeh
Abstract: Preterm birth is a major health problem in the United States. In Puerto Rico, the preterm birth rate has increased to nearly 20% of live births and there is sufficient evidence that exposure to Superfund and related contaminants is a contributing factor. The theme of the PRoTECT Program is to use Puerto Rico as a testsite with dynamic exposure pathways through karstic aquifers to study Superfund and related contaminants and their contribution to preterm birth. The two goals of the Program are to: (1) Define the relationship between exposure to Superfund and related contaminants and preterm birth;and (2) Develop new technology for discovery, transport characterization, and green remediation of Superfund and related contaminants in karstic aquifers. To achieve these goals, the PRoTECT program will use a comprehensive, multidisciplinary approach that will ultimately lead to a better understanding of causal relationships between the exposures and preterm births, and will allow development of innovative remediation strategies to reduce short-term contaminant exposures, and long-term public health impacts. The five objectives of the Program are to: (1) Increase the evidence that Superfund and related contaminants contribute to preterm birth, identify the causative chemicals, and learn how to remediate these chemicals in karstic aquifers by a green process;(2) Build a better understanding of the potential role, mechanisms and relevance of pollution induced oxidative stress in preterm birth, (3) Discover and understand risk factors and their interactions for preterm birth by developing and mining an integrated, centralized, indexed data repository for Puerto Rico that includes epidemiological, hydrogeophysical, environmental fate and transport, and environmental exposure data, (4) Determine the effect of episodic transport on patterns of exposure through highly mobile karstic aquifers and develop adaptable remedial actions, and (5) Improve and apply nontargeted chemical analysis including bioassay-directed chemical analysis to biological samples and environmental samples. The PROTECT Program will conduct targeted and nontargeted studies to evaluate the contribution of exposure to Superfund and related contaminants to preterm birth. The targeted studies focus on chlorinated solvents and phthalates because they are suspect and model contaminants and because they are found in many Superfund sites in the US and Puerto Rico. The cross-disciplinary approach will employ the data-rich centralized data repository and integrated modeling/analysis capabilities to better understand complex interrelationships between multiple risk factors.
Funding Period: 2010-04-12 - 2014-03-31
more information: NIH RePORT

Top Publications

  1. pmc Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry
    Yuanyuan Yao
    Department of Pharmaceutical Sciences and Barnett Institute, Bouve College, Northeastern University, Boston, MA, 02115, USA
    Rapid Commun Mass Spectrom 28:653-61. 2014
  2. pmc Environmental contaminant exposures and preterm birth: a comprehensive review
    Kelly K Ferguson
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    J Toxicol Environ Health B Crit Rev 16:69-113. 2013
  3. pmc Antimicrobial peptide response to group B Streptococcus in human extraplacental membranes in culture
    E Boldenow
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Placenta 34:480-5. 2013
  4. pmc Distribution, variability, and predictors of urinary concentrations of phenols and parabens among pregnant women in Puerto Rico
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, United States
    Environ Sci Technol 47:3439-47. 2013
  5. pmc Malondialdehyde-deoxyguanosine and bulky DNA adducts in schoolchildren resident in the proximity of the Sarroch industrial estate on Sardinia Island, Italy
    Marco Peluso
    Cancer Risk Factor Branch, Cancer Prevention and Research Institute, Via il Vecchio 2, 50139 Florence, Italy
    Mutagenesis 28:315-21. 2013
  6. pmc Troubleshooting the dichlorofluorescein assay to avoid artifacts in measurement of toxicant-stimulated cellular production of reactive oxidant species
    Lauren M Tetz
    Environmental Health Sciences Department, University of Michigan School of Public Health, Ann Arbor, MI 48109 2029, USA
    J Pharmacol Toxicol Methods 67:56-60. 2013
  7. ncbi Exposure to environmental endocrine disruptors and child development
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Arch Pediatr Adolesc Med 166:952-8. 2012
  8. pmc Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro
    Lauren M Tetz
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Toxicol Appl Pharmacol 268:47-54. 2013
  9. pmc Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008
    Erika S Koeppe
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Sci Total Environ 445:299-305. 2013
  10. ncbi Electrocatalytic activity of Pd-loaded Ti/TiO2 nanotubes cathode for TCE reduction in groundwater
    Wenjing Xie
    State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, PR China
    Water Res 47:3573-82. 2013

Research Grants

  1. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
  2. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013

Detail Information

Publications54

  1. pmc Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry
    Yuanyuan Yao
    Department of Pharmaceutical Sciences and Barnett Institute, Bouve College, Northeastern University, Boston, MA, 02115, USA
    Rapid Commun Mass Spectrom 28:653-61. 2014
    ..We chose SBA for this purpose since it is commercially available, inexpensive, and forms an anionic derivative...
  2. pmc Environmental contaminant exposures and preterm birth: a comprehensive review
    Kelly K Ferguson
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    J Toxicol Environ Health B Crit Rev 16:69-113. 2013
    ..By identifying limitations and addressing the gaps that may have impeded the ability to identify true associations thus far, this review can guide future epidemiologic studies of environmental exposures and preterm birth...
  3. pmc Antimicrobial peptide response to group B Streptococcus in human extraplacental membranes in culture
    E Boldenow
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Placenta 34:480-5. 2013
    ..This study characterizes GBS colonization and stimulation of antimicrobial responses in human extraplacental membranes using an ex vivo transwell two-compartment system of full-thickness membranes and live GBS...
  4. pmc Distribution, variability, and predictors of urinary concentrations of phenols and parabens among pregnant women in Puerto Rico
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, United States
    Environ Sci Technol 47:3439-47. 2013
    ..Our results can inform future epidemiology studies and strategies to reduce exposure to these chemicals or their precursors...
  5. pmc Malondialdehyde-deoxyguanosine and bulky DNA adducts in schoolchildren resident in the proximity of the Sarroch industrial estate on Sardinia Island, Italy
    Marco Peluso
    Cancer Risk Factor Branch, Cancer Prevention and Research Institute, Via il Vecchio 2, 50139 Florence, Italy
    Mutagenesis 28:315-21. 2013
    ..The means ratio was 1.90, 95% CI: 1.25-2.89, P = 0.003 versus rural controls. Our study indicates that children residing near the industrial estate have a significant increment of DNA damage...
  6. pmc Troubleshooting the dichlorofluorescein assay to avoid artifacts in measurement of toxicant-stimulated cellular production of reactive oxidant species
    Lauren M Tetz
    Environmental Health Sciences Department, University of Michigan School of Public Health, Ann Arbor, MI 48109 2029, USA
    J Pharmacol Toxicol Methods 67:56-60. 2013
    ..We evaluated the utility of the DCF assay for measuring ROS generation by the toxicants mono-(2-ethylhexyl) phthalate (MEHP), and tetrabromobisphenol A (TBBPA)...
  7. ncbi Exposure to environmental endocrine disruptors and child development
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Arch Pediatr Adolesc Med 166:952-8. 2012
    ....
  8. pmc Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro
    Lauren M Tetz
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Toxicol Appl Pharmacol 268:47-54. 2013
    ..The findings from the current study warrant future mechanistic studies of oxidative stress, apoptosis, and prostaglandins as molecular mediators of DEHP/MEHP-associated adverse pregnancy outcomes...
  9. pmc Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008
    Erika S Koeppe
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Sci Total Environ 445:299-305. 2013
    ..Further research is needed for confirmation and to determine the potential clinical and public health significance of these findings...
  10. ncbi Electrocatalytic activity of Pd-loaded Ti/TiO2 nanotubes cathode for TCE reduction in groundwater
    Wenjing Xie
    State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, PR China
    Water Res 47:3573-82. 2013
    ..Compared with other common cathodes, i.e., Ti-based mixed metal oxides, graphite and Pd/Ti, Pd-Ti/TiO2NTs cathode shows superior performance for TCE reduction...
  11. pmc Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age
    Martha M Téllez-Rojo
    Division of Statistics, Center for Evaluation Research and Surveys, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    Sci Total Environ 461:386-90. 2013
    ..Previous studies suggest that prenatal phthalate exposure affects neurodevelopment and behavior during the first years of life...
  12. pmc Electrolytic manipulation of persulfate reactivity by iron electrodes for trichloroethylene degradation in groundwater
    Songhu Yuan
    State Key Lab of Biogeology and Environmental Geology, China University of Geosciences, 388 Lumo Road, Wuhan, Hubei 430074, P R China
    Environ Sci Technol 48:656-63. 2014
    ....
  13. pmc Environmental phthalate exposure and preterm birth
    Kelly K Ferguson
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor
    JAMA Pediatr 168:61-7. 2014
    ..Phthalate diesters are used extensively in a variety of consumer products worldwide. Consequently, exposure in pregnant women is highly prevalent...
  14. pmc Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: distribution, temporal variability, and predictors
    David E Cantonwine
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, United States Electronic address
    Environ Int 62:1-11. 2014
    ..The objective of this study was to determine concentrations and predictors of urinary phthalate biomarkers measured at multiple times during pregnancy among women living in the Northern karst area of Puerto Rico...
  15. pmc Aberrant methylation of hypermethylated-in-cancer-1 and exocyclic DNA adducts in tobacco smokers
    Marco E M Peluso
    Cancer Risk Factor Branch, Cancer Prevention and Research Institute, Florence, Italy
    Toxicol Sci 137:47-54. 2014
    ....
  16. pmc Statistical strategies for constructing health risk models with multiple pollutants and their interactions: possible choices and comparisons
    Zhichao Sun
    Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI USA
    Environ Health 12:85. 2013
    ....
  17. pmc Predictors of urinary bisphenol A and phthalate metabolite concentrations in Mexican children
    Ryan C Lewis
    University of Michigan, School of Public Health, Department of Environmental Health Sciences, Ann Arbor, MI, USA
    Chemosphere 93:2390-8. 2013
    ..Due to rapid development, children may be susceptible to impacts from exposure to endocrine disrupting chemicals; thus, reduced or delayed use of certain personal care products among children may be warranted...
  18. ncbi Iron anode mediated transformation of selenate in sand columns
    Kitae Baek
    Department of Environmental Engineering, Chonbuk National University, 567 Baekje daero, Deokjin gu, Jeonju, Republic of Korea Electronic address
    Water Res 47:6538-45. 2013
    ..A sequence of cathode-anode was ineffective in removing selenate because of the lack of reducing agent in the column. The results indicate that the electrochemical system might be effective in removing selenate in a single well...
  19. pmc Nuclear magnetic resonance at the picomole level of a DNA adduct
    Roger Kautz
    Barnett Institute of Chemical and Biological Analysis, Department of Pharmaceutical Sciences in the Bouve College of Health Sciences, and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States
    Chem Res Toxicol 26:1424-9. 2013
    ..6 μg in 18 h. This work helps to define the utility of NMR in combination with other analytical methods for the structural characterization of a small amount of a DNA adduct...
  20. pmc Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: distribution, temporal variability, and relationship with child attention and hyperactivity
    Gamola Z Fortenberry
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Int J Hyg Environ Health 217:405-12. 2014
    ....
  21. pmc Effects of reduced sulfur compounds on Pd-catalytic hydrodechlorination of trichloroethylene in groundwater by cathodic H2 under electrochemically induced oxidizing conditions
    Songhu Yuan
    State Key Lab of Biogeology and Environmental Geology, China University of Geosciences, 388 Lumo Road, Wuhan, Hubei, 430074, P R China
    Environ Sci Technol 47:10502-9. 2013
    ..This study reveals a distinct mechanism of effect of sulfite on TCE hydrodechlorination by Pd and H2 in oxic groundwater and presents an alternative approach to increasing resistance of Pd to RSCs poisoning. ..
  22. pmc Optimization of electrochemical dechlorination of trichloroethylene in reducing electrolytes
    Xuhui Mao
    Civil and Environmental Engineering Department, Northeastern University, Boston, MA 02115, USA
    Water Res 46:1847-57. 2012
    ....
  23. pmc A generalized model for transport of contaminants in soil by electric fields
    Juan Manuel Paz-Garcia
    Department of Civil Engineering, Technical University of Denmark, Copenhagen, Denmark
    J Environ Sci Health A Tox Hazard Subst Environ Eng 47:308-18. 2012
    ..The model showed that kinetics of geochemical reactions, such as metals dissolution/leaching and redox reactions, may be significant for realistic prediction of enhanced electrokinetic extraction of metals in real-world applications...
  24. pmc Exploration of oxidative stress and inflammatory markers in relation to urinary phthalate metabolites: NHANES 1999-2006
    Kelly K Ferguson
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, Michigan 48109 2029, United States
    Environ Sci Technol 46:477-85. 2012
    ..These markers may be useful in other studies of low-dose exposure to environmental contaminants...
  25. pmc Fruit and vegetable and fried food consumption and 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α] purin-10(3H)-one deoxyguanosine adduct formation
    Marco Peluso
    Cancer Risk Factor Branch, ISPO Cancer Prevention and Research Institute, Florence, Italy
    Free Radic Res 46:85-92. 2012
    ..88, CI 1.14-3.10, p < 0.05), but not in workers. M(1)dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practices should be recommended...
  26. pmc Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 119:1396-402. 2011
    ..Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling...
  27. pmc Redox control for electrochemical dechlorination of trichloroethylene in bicarbonate aqueous media
    Xuhui Mao
    Civil and Environmental Engineering Department, Northeastern University, Boston, Massachusetts 02115, United States
    Environ Sci Technol 45:6517-23. 2011
    ..Enhanced reaction rates in this investigation indicate that the electrochemical reduction using copper foam and iron anode may be a promising process for remediation of groundwater contaminated with chlorinated organic compounds...
  28. pmc Urinary phthalate metabolites in relation to biomarkers of inflammation and oxidative stress: NHANES 1999-2006
    Kelly K Ferguson
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Environ Res 111:718-26. 2011
    ..On the other hand, several oxidized phthalate metabolites were inversely associated with these markers. These relationships deserve further exploration in both experimental and observational studies...
  29. pmc Breast fine-needle aspiration malondialdehyde deoxyguanosine adduct in breast cancer
    Marco Peluso
    Cancer Risk Factor Branch, ISPO Cancer Prevention and Research Institute, Florence, Italy
    Free Radic Res 45:477-82. 2011
    ..58, 95% CI = 0.92-2.72 and MR = 1.68, 95% CI 0.88-3.20, respectively). An increment over the background frequency of M₁dG can contribute to breast cancer development. Increasing severity of breast tumour can influence DNA damage level...
  30. pmc Bisphenol a exposure in Mexico City and risk of prematurity: a pilot nested case control study
    David Cantonwine
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health 9:62. 2010
    ....
  31. pmc Tissue-specific induction of COX-2 and prostaglandins in lipopolysaccharide-stimulated extraplacental human gestational membranes in a 2-chamber transwell culture system
    Natalie W Thiex
    Department of Environmental Health Sciences, School of Public Health, The University of Michigan, Ann Arbor, MI, USA
    Reprod Sci 17:1120-9. 2010
    ....
  32. pmc Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure
    Roberto Bono
    Department of Public Health and Microbiology, University of Turin, Italy, Via Santena 5 bis, Turin, Italy
    Chem Res Toxicol 23:1342-8. 2010
    ..075, Pearson correlation) in the formation of M(1)-dG, only in nonsmokers. Working in the reduction rooms and exposure to air-formaldehyde concentrations higher than 66 microg/m(3) are associated with increased levels of M(1)-dG adducts...
  33. pmc Efficient degradation of TCE in groundwater using Pd and electro-generated H2 and O2: a shift in pathway from hydrodechlorination to oxidation in the presence of ferrous ions
    Songhu Yuan
    State Key Lab of Biogeology and Environmental Geology, China University of Geosciences, 388 Lumo Road, Wuhan 430074, PR China
    Environ Sci Technol 46:3398-405. 2012
    ..A novel Pd-based electrochemical process is proposed for groundwater remediation...
  34. pmc Urinary phthalate metabolites and their biotransformation products: predictors and temporal variability among men and women
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Expo Sci Environ Epidemiol 22:376-85. 2012
    ..Conversely, the proportion of DEHP metabolites contributed to by MEHP was more stable within individuals over time and may be a promising indicator of susceptibility if time of day of sample collection is carefully considered...
  35. pmc Electrokinetic-enhanced bioaugmentation for remediation of chlorinated solvents contaminated clay
    Xuhui Mao
    Civil and Environmental Engineering Department, Northeastern University, Boston, MA 02115, USA
    J Hazard Mater 213:311-7. 2012
    ..Compared with conventional advection-based delivery, EK injection is significantly more effective for establishing microbial reductive dechlorination capacity in low-permeability soils...
  36. pmc A three-electrode column for Pd-catalytic oxidation of TCE in groundwater with automatic pH-regulation and resistance to reduced sulfur compound foiling
    Songhu Yuan
    State Key Lab of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, PR China
    Water Res 47:269-78. 2013
    ..e., O(2), H(2)O(2) and OH, can oxidize RSCs to some extent. In particular, sulfite at concentrations less than 1 mM even greatly increases TCE oxidation by the production of SO(4)(•-), a strong oxidizing radical, and more OH...
  37. pmc Nontargeted analysis of DNA adducts by mass-tag MS: reaction of p-benzoquinone with DNA
    Poguang Wang
    Department of Pharmaceutical Sciences and Barnett Institute, Northeastern University, Boston, Massachusetts 02115, United States
    Chem Res Toxicol 25:2737-43. 2012
    ..Because the calf thymus DNA (used as received) was contaminated with RNA, we also detected the ribonucleotide adduct, BQ-CMP...
  38. pmc Electrochemically induced dual reactive barriers for transformation of TCE and mixture of contaminants in groundwater
    Xuhui Mao
    School of Resources and Environmental Science, Wuhan University, Wuhan 430079, PR China
    Environ Sci Technol 46:12003-11. 2012
    ..The overall system, comprising the electrode-based and electrolyte-based barriers, can be engineered as a versatile and integrated remedial method for a relatively wide spectrum of contaminants and their mixtures...
  39. pmc Isolation and molecular identification of landfill bacteria capable of growing on di-(2-ethylhexyl) phthalate and deteriorating PVC materials
    Isomar Latorre
    Department of Civil Engineering, University of Puerto Rico, Mayaguez, Puerto Rico 00681
    J Environ Sci Health A Tox Hazard Subst Environ Eng 47:2254-62. 2012
    ..When augmented to the reactors with PVC shower curtains containing DEHP, strains LHM1 and LHM2 developed greater optical densities in the solution phase and thicker biofilm on the surfaces of the shower curtains...
  40. pmc Reduced birth weight in relation to pesticide mixtures detected in cord blood of full-term infants
    Erin L Wickerham
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Environ Int 47:80-5. 2012
    ..Additional research is needed to establish causality and to understand the function and impact of fungicides and pesticide mixtures on fetal development...
  41. pmc Serum concentrations of p, p'-DDE, HCB, PCBs and reproductive hormones among men of reproductive age
    Kelly K Ferguson
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109 2029, United States
    Reprod Toxicol 34:429-35. 2012
    ..These results suggest a minimal relationship between PCB exposures at low background levels similar to those observed in the general population of the US and circulating reproductive hormones...
  42. pmc Association between urinary 3, 5, 6-trichloro-2-pyridinol, a metabolite of chlorpyrifos and chlorpyrifos-methyl, and serum T4 and TSH in NHANES 1999-2002
    Gamola Z Fortenberry
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Sci Total Environ 424:351-5. 2012
    ..Further research to confirm these findings, elucidate mechanisms of action, and explore the clinical and public health significance of such alterations in thyroid hormones is needed...
  43. pmc Electrode effects on temporal changes in electrolyte pH and redox potential for water treatment
    Ali Ciblak
    Department of Civil and Environmental Engineering, Northeastern University, Boston, Massachusetts 02115, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 47:718-26. 2012
    ..The study shows that a highly reducing environment could be achieved using iron anodes in divided or mixed electrolytes and the pH and redox potential could be optimized using appropriate current and polarity reversal...
  44. pmc Nontargeted nucleotide analysis based on benzoylhistamine labeling-MALDI-TOF/TOF-MS: discovery of putative 6-oxo-thymine in DNA
    Poguang Wang
    Pharmaceutical Science and Barnett Institute, Northeastern University, Boston, Massachusetts 02115, United States
    Anal Chem 84:3811-9. 2012
    ..The method provides deoxynucleotide-specific detection, accurate measurement of molecular ions, high sensitivity, semiquantitation, and, to the extent studied to date, normalization of response within a factor of <3...
  45. pmc Urinary phthalate metabolites in relation to preterm birth in Mexico city
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 117:1587-92. 2009
    ..Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role...

Research Grants30

  1. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
    ..We plan to build research capacity in the Center and other organizations, enhance careers of new investigators, and make key findings accessible to researchers, policy makers, practitioners, and the public. ..
  2. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
    ..This Program is highly relevant to Superfund by addressing high-priority chemicals and by focusing on mechanisms underlying health effects, exposure assessment, and remediation to mitigate exposure and toxicity. ..