TOXIC SUBSTANCES IN THE ENVIRONMENT

Summary

Principal Investigator: Martyn T Smith
Abstract: DESCRIPTION (provided by applicant): The overall theme of the Berkeley Superfund Research Program (SRP) is using state-of-the-art technology, including 'omics'and nanotechnology, to (1) develop biological markers and apply them in human population studies, especially those involving susceptible populations such as children and pregnant women;(2) to improve chemical detection;and, (3) facilitate and lower the cost of waste site remediation. The proposed program builds on the strengths of UC Berkeley and Lawrence Berkeley National Laboratory in engineering, chemistry, and molecular epidemiology. The highly integrated program consists of six interrelated projects (three with a biomedical research focus and three with a non-biomedical research focus) and four cores. Our research team will focus on environmental exposures currently encountered at hazardous waste sites and several contaminants of emerging human health concern. All SRP mandates will be addressed. Projects 1, 2, 3 and 6 specifically aim to develop advanced techniques for the detection, assessment, and evaluation of the effect of hazardous substances on human health and improve methods to assess the risks to human health presented by benzene, arsenic, trichloroethylene and other hazardous substances. Project 5 will use nanotechnology to develop methods to detect hazardous substances in the environment in a simple, inexpensive fashion. Projects 4 and 6 will develop biological, chemical, and physical methods to remediate waste sites and reduce the amount and toxicity of hazardous substances. A Genomics and Analytical Chemistry core (C) and a Quantitative Biology core (D) will assist project researchers in meeting their goals. A Research Translation core (B) will facilitate intensive discussions between investigators and government audiences, and generate new initiatives to increase understanding of the significance and applicability of research to public health protection. The overall goal is to enhance understanding of the relationship between exposure and disease;provide usable tools to improve human health risk assessments;and, develop a range of prevention and remediation strategies to improve and protect public health and the environment. The program will be overseen and coordinated by an Administration core (A).
Funding Period: 1997-04-01 - 2016-03-31
more information: NIH RePORT

Top Publications

  1. pmc Reliability of maternal-reports regarding the use of household pesticides: experience from a case-control study of childhood leukemia
    Danna A Slusky
    School of Public Health, University of California, Berkeley, CA 94704, USA
    Cancer Epidemiol 36:375-80. 2012
  2. pmc Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics NCI, NIH, DHHS, Bethesda MD 20892, U S A
    Exp Mol Med 43:374-8. 2011
  3. pmc Exposure to electrical contact currents and the risk of childhood leukemia
    Monique Does
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Radiat Res 175:390-6. 2011
  4. pmc Benzene, the exposome and future investigations of leukemia etiology
    Martyn T Smith
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 192:155-9. 2011
  5. pmc Early life exposure to infections and risk of childhood acute lymphoblastic leukemia
    Kevin Y Urayama
    School of Public Health, University of California, Berkeley, CA, USA
    Int J Cancer 128:1632-43. 2011
  6. pmc Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells
    Xuefeng Ren
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e14546. 2011
  7. pmc Comparative genomics of two newly isolated Dehalococcoides strains and an enrichment using a genus microarray
    Patrick K H Lee
    Department of Civil and Environmental Engineering, University of California, Berkeley, USA
    ISME J 5:1014-24. 2011
  8. pmc Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 32:605-12. 2011
  9. pmc Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity
    Xuefeng Ren
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:771-7. 2011
  10. pmc Evidence from Chile that arsenic in drinking water may increase mortality from pulmonary tuberculosis
    Allan H Smith
    Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, USA
    Am J Epidemiol 173:414-20. 2011

Research Grants

  1. DETECTION AND MODELS OF TOXICANT EXPOSURE
    Robert H Tukey; Fiscal Year: 2013
  2. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
  3. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
  4. BIOMARKERS OF EXPOSURE TO HAZARDOUS SUBSTANCES
    Bruce D Hammock; Fiscal Year: 2013
  5. Superfund Metal Mixtures, Biomarkers and Neurodevelopment
    David C Bellinger; Fiscal Year: 2013
  6. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
  7. PAHs: New Technologies and Emerging Health Risks
    David E Williams; Fiscal Year: 2013

Detail Information

Publications202 found, 100 shown here

  1. pmc Reliability of maternal-reports regarding the use of household pesticides: experience from a case-control study of childhood leukemia
    Danna A Slusky
    School of Public Health, University of California, Berkeley, CA 94704, USA
    Cancer Epidemiol 36:375-80. 2012
    ..The aim of this study is to assess the reliability of self-reported household use of pesticides and potential differences in reliability by case-control status, and by socio-demographic characteristics...
  2. pmc Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics NCI, NIH, DHHS, Bethesda MD 20892, U S A
    Exp Mol Med 43:374-8. 2011
    ..0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary...
  3. pmc Exposure to electrical contact currents and the risk of childhood leukemia
    Monique Does
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Radiat Res 175:390-6. 2011
    ....
  4. pmc Benzene, the exposome and future investigations of leukemia etiology
    Martyn T Smith
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 192:155-9. 2011
    ..We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology...
  5. pmc Early life exposure to infections and risk of childhood acute lymphoblastic leukemia
    Kevin Y Urayama
    School of Public Health, University of California, Berkeley, CA, USA
    Int J Cancer 128:1632-43. 2011
    ..45, 95% CI: 0.25-0.79). Evidence of a protective role for infection-related exposures early in life is supported by findings in both the non-Hispanic white and Hispanic populations within the NCCLS...
  6. pmc Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells
    Xuefeng Ren
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e14546. 2011
    ..The aim of the present study was to examine the effects of silencing WRN in p53 deficient HL60 and p53 wild-type TK6 hematopoietic cells, in order to further the understanding of WRN-associated tumorigenesis...
  7. pmc Comparative genomics of two newly isolated Dehalococcoides strains and an enrichment using a genus microarray
    Patrick K H Lee
    Department of Civil and Environmental Engineering, University of California, Berkeley, USA
    ISME J 5:1014-24. 2011
    ..Overall, the microarrays are a valuable high-throughput tool for comparative genomics of unsequenced Dehalococcoides-containing samples to provide insights into their gene content and dechlorination functions...
  8. pmc Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 32:605-12. 2011
    ..Together, these findings confirm that benzene exposure is associated with specific chromosomal aneuploidies in hematopoietic cells, which suggests that such aneuploidies may play roles in benzene-induced leukemogenesis...
  9. pmc Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity
    Xuefeng Ren
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:771-7. 2011
    ..We found that yeast deletion mutants lacking MTQ2 were highly resistant to iAs exposure. The human ortholog of the yeast MTQ2 is N-6 adenine-specific DNA methyltransferase 1 (N6AMT1), encoding a putative methyltransferase...
  10. pmc Evidence from Chile that arsenic in drinking water may increase mortality from pulmonary tuberculosis
    Allan H Smith
    Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, USA
    Am J Epidemiol 173:414-20. 2011
    ..Finding weaker associations in women is unsurprising, because this is true of most arsenic-caused health effects. Confirmatory evidence is needed from other arsenic-exposed populations...
  11. pmc Global gene expression profiling of a population exposed to a range of benzene levels
    Cliona M McHale
    School of Public Health, University of California Berkeley, Berkeley, California 64720, USA
    Environ Health Perspect 119:628-34. 2011
    ..Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers...
  12. pmc Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India
    Arin Basu
    Arsenic Health Effects Research Group, School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Health Perspect 119:1308-13. 2011
    ..Methylation may have an important role in arsenic toxicity, because the monomethylated trivalent metabolite [MMA(III)] is highly toxic...
  13. pmc Profound deficit of IL10 at birth in children who develop childhood acute lymphoblastic leukemia
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143 0520, USA
    Cancer Epidemiol Biomarkers Prev 20:1736-40. 2011
    ..The current study examines the association between neonatal cytokine profiles, a proxy measure for a child's prenatal immune development, and childhood ALL...
  14. pmc Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia
    Catherine Metayer
    School of Public Health, University of California, Berkeley, 1995 University Avenue, Suite 460, Berkeley, CA 94704 7392, USA
    Cancer Causes Control 22:1243-58. 2011
    ..We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk...
  15. pmc Global transcriptomic and proteomic responses of Dehalococcoides ethenogenes strain 195 to fixed nitrogen limitation
    Patrick K H Lee
    Department of Civil and Environmental Engineering, University of California, Berkeley, CA, USA
    Appl Environ Microbiol 78:1424-36. 2012
    ..Overall, this study elucidates the molecular responses of strain 195 to FNL and identifies differentially expressed genes that are potential biomarkers to evaluate environmental cellular nitrogen status...
  16. pmc Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment
    Cliona M McHale
    Division of Environmental Health Sciences, Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Carcinogenesis 33:240-52. 2012
    ..These approaches will inform our understanding of the mechanisms of benzene toxicity and identify additional biomarkers of exposure, early effect and susceptibility useful for risk assessment...
  17. pmc Inhibitory effect of dissolved silica on H₂O₂ decomposition by iron(III) and manganese(IV) oxides: implications for H₂O₂-based in situ chemical oxidation
    Anh Le Tuan Pham
    Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, California 94720, United States
    Environ Sci Technol 46:1055-62. 2012
    ..The presence of dissolved SiO(2) results in greater persistence of H(2)O(2) in groundwater and lower H(2)O(2) utilization efficiency and should be considered in the design of H(2)O(2)-based treatment systems...
  18. pmc Phylogenetic microarray analysis of a microbial community performing reductive dechlorination at a TCE-contaminated site
    Patrick K H Lee
    Department of Civil and Environmental Engineering, University of California Berkeley, Berkeley, California, United States of America
    Environ Sci Technol 46:1044-54. 2012
    ..Overall, the PhyloChip analyses in this study have provided insights into the microbial ecology and population dynamics at the TCE-contaminated field site useful for understanding the in situ reductive dechlorination processes...
  19. pmc Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men
    Francesco Marchetti
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Environ Health Perspect 120:229-34. 2012
    ..We previously reported that occupational exposures near the U.S. Occupational Safety and Health Administration permissible exposure limit (8 hr) of 1 ppm was associated with sperm aneuploidy...
  20. ncbi Comparison of racial differences in childhood cancer risk in case-control studies and population-based cancer registries
    Danna A Slusky
    School of Public Health, University of California, Berkeley, CA 94704, USA
    Cancer Epidemiol 36:36-44. 2012
    ....
  21. pmc Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia
    Anand P Chokkalingam
    Division of Epidemiology, School of Public Health, University of California Berkeley, 1995 University Avenue, Berkeley, CA 94704, USA
    Cancer Causes Control 22:1721-30. 2011
    ..These abnormalities may be influenced by altered DNA repair and cell cycle control processes...
  22. pmc Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast
    Matthew North
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e24205. 2011
    ..Many of the yeast genes identified have human orthologs that may modulate human benzene toxicity in a similar manner and could play a role in benzene exposure-related disease...
  23. pmc Multilocus fragment typing and genetic structure of Cryptosporidium parvum Isolates from diarrheic preweaned calves in Spain
    Joaquin Quilez
    Department of Animal Pathology, Faculty of Veterinary Sciences, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
    Appl Environ Microbiol 77:7779-86. 2011
    ..Bayesian structure analysis based on combined data for both satellite and GP60 loci suggested the presence of two major clusters among the C. parvum isolates from cattle farms in this geographical area...
  24. pmc Selective utilization of exogenous amino acids by Dehalococcoides ethenogenes strain 195 and its effects on growth and dechlorination activity
    Wei Qin Zhuang
    Department of Civil and Environmental Engineering, University of California, Berkeley, California 94720, USA
    Appl Environ Microbiol 77:7797-803. 2011
    ..This study also demonstrates that using isotopomer-based metabolite analysis can be an efficient strategy for optimizing nutritional conditions for slow-growing microorganisms...
  25. ncbi Quantitative mass spectrometry reveals the epigenome as a target of arsenic
    Feixia Chu
    Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA
    Chem Biol Interact 192:113-7. 2011
    ..Furthermore, MYST1 was shown to be the major histone acetyltransferase for H4 Lys16 and protect UROtsa cells from arsenic toxicity...
  26. ncbi A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide
    Z Ji
    Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720 7360, USA
    Leukemia 24:986-91. 2010
    ..In addition to cytogenetic changes, global DNA hypomethylation may be another mechanism underlying the leukemogenicity of benzene...
  27. pmc A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia
    Kevin Y Urayama
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Int J Epidemiol 39:718-32. 2010
    ..A meta-analysis was conducted to examine the relationship between day-care attendance and risk of childhood ALL, specifically to address whether early-life exposure to infection is protective against ALL...
  28. ncbi Advances in understanding benzene health effects and susceptibility
    Martyn T Smith
    Superfund Research Program, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Annu Rev Public Health 31:133-48 2 p following 148. 2010
    ..There is probably no safe level of exposure to benzene, and all exposures constitute some risk in a linear, if not supralinear, and additive fashion...
  29. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
    ....
  30. pmc Determinants of polycyclic aromatic hydrocarbon levels in house dust
    Todd Whitehead
    School of Public Health, University of California, Berkeley, California 94720, USA
    J Expo Sci Environ Epidemiol 21:123-32. 2011
    ..As self-reported data and outdoor PAH sources were only marginally predictive of observed PAH levels, we recommend that PAH concentrations be measured directly in dust samples for use in epidemiological studies...
  31. pmc Human benzene metabolism following occupational and environmental exposures
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:189-95. 2010
    ..1 ppm, 20 and 58% at 1 ppm, and 2.7 and 17% at 10 ppm. This indicates that the putative high-affinity enzyme was active primarily below 1 ppm and favored the ring-opening pathway...
  32. pmc Systems biology of human benzene exposure
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:86-93. 2010
    ....
  33. ncbi Kidney cancer mortality: fifty-year latency patterns related to arsenic exposure
    Yan Yuan
    Arsenic Health Effects Research Program, University of California, Berkeley, CA 94720 7360, USA
    Epidemiology 21:103-8. 2010
    ..Beginning in 1958, a region of Chile experienced a rapid onset of high arsenic exposure in drinking water, followed by sharp declines when water treatment plants were installed in 1971...
  34. pmc A silica-supported iron oxide catalyst capable of activating hydrogen peroxide at neutral pH values
    Anh Le Tuan Pham
    Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, California 94720, USA
    Environ Sci Technol 43:8930-5. 2009
    ....
  35. pmc Toxicogenomic profiling of chemically exposed humans in risk assessment
    Cliona M McHale
    School of Public Health, Divisions of Environmental Health Sciences, and Biostatistics, University of California, Berkeley, CA 94720, USA
    Mutat Res 705:172-83. 2010
    ....
  36. pmc Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy
    Caihong Xing
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Environ Health Perspect 118:833-9. 2010
    ..Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Occupational Safety and Health Administration...
  37. pmc Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 31:1592-6. 2010
    ..Given that altered immunity is an established risk factor for NHL, these results add to the biologic plausibility that TCE is a possible lymphomagen...
  38. pmc Lung function in adults following in utero and childhood exposure to arsenic in drinking water: preliminary findings
    David C Dauphiné
    Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Int Arch Occup Environ Health 84:591-600. 2011
    ..We conducted a pilot study on early-life arsenic exposure and long-term lung function. We present these preliminary findings because of the magnitude of the effects observed...
  39. pmc Diagnostic X-rays and risk of childhood leukaemia
    Karen Bartley
    School of Public Health, University of California, Berkeley, CA, USA
    Int J Epidemiol 39:1628-37. 2010
    ..The association between diagnostic X-ray exposures early in life and increased risk of childhood leukaemia remains unclear...
  40. ncbi Selected technologies for measuring acquired genetic damage in humans
    Joe Shuga
    School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Mol Mutagen 51:851-70. 2010
    ..The technologies discussed in this review will significantly expand our knowledge of acquired genetic mutations and causative mechanisms...
  41. ncbi Biphenyl and ethylbenzene dioxygenases of Rhodococcus jostii RHA1 transform PBDEs
    Kristin R Robrock
    Department of Civil and Environmental Engineering, University of California, Berkeley, USA
    Biotechnol Bioeng 108:313-21. 2011
    ..The availability of substrates or inducing compounds can markedly affect total PBDE removal as well as patterns of removal of individual congeners...
  42. pmc Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
    Cancer Epidemiol Biomarkers Prev 19:2152-63. 2010
    ..The lack of immune priming in early childhood may result in abnormal immune responses to infections later in life and increase ALL risk...
  43. pmc Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, and Helen Diller Comprehensive Cancer Center, University of California San Francisco, CA 94158, USA
    Blood Cells Mol Dis 45:186-91. 2010
    ..We posit a natural history for hyperdiploid leukemia in which prenatal mitotic catastrophe is followed by a postnatal RAS mutation to produce the leukemic cell phenotype...
  44. pmc An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:11-9. 2011
    ..Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure...
  45. pmc Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism
    Kristin E Porter
    School of Public Health, 237A Hildebrand Hall, University of California, Berkeley, CA 94720 7356, USA
    Environ Res 110:580-7. 2010
    ..No other genetic associations were found. These findings are the first to suggest that CBS polymorphisms may influence arsenic metabolism in humans and susceptibility to arsenic-related disease...
  46. pmc Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
    Craig Steinmaus
    Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, USA
    Toxicol Appl Pharmacol 247:138-45. 2010
    ..These results add to the increasing body of evidence that variation in arsenic metabolism plays an important role in arsenic-disease susceptibility...
  47. pmc Application of OMICS technologies in occupational and environmental health research; current status and projections
    J Vlaanderen
    Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, University Utrecht, PO Box 80178, 3508 TD, Utrecht, The Netherlands
    Occup Environ Med 67:136-43. 2010
    ..To illustrate the current status of the application of OMICS in OEH research, we will provide examples of studies that used OMICS technologies to investigate human health effects of two well-known toxicants, benzene and arsenic...
  48. ncbi Comparison of aneuploidies of chromosomes 21, X, and Y in the blood lymphocytes and sperm of workers exposed to benzene
    Zhiying Ji
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    Environ Mol Mutagen 53:218-26. 2012
    ..The findings suggest that benzene exposure induces aneuploidies in both blood cells and sperm within the same individuals, but selectively affects chromosome 21 in blood lymphocytes and the sex chromosomes in sperm...
  49. pmc Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure
    Reuben Thomas
    Superfund Research Program, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 9:e91828. 2014
    ..Studies with extensive exposure assessment of subjects exposed in the low-dose range between 10 ppb and 1 ppm are needed to confirm these findings. ..
  50. ncbi Arsenic, tobacco smoke, and occupation: associations of multiple agents with lung and bladder cancer
    Catterina Ferreccio
    From the aDepartamento de Salud Pública, Universidad Catolica de Chile, Santiago, Chile bArsenic Research Group, School of Public Health, University of California, Berkeley, CA and cHospital de Antofagasta, Antofagasta, Chile
    Epidemiology 24:898-905. 2013
    ..Millions of people worldwide are exposed to arsenic in drinking water, and many are likely coexposed to other agents that could substantially increase their risks of arsenic-related cancer...
  51. pmc Arsenic immunotoxicity: a review
    Nygerma L Dangleben
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Environ Health 12:73. 2013
    ....
  52. ncbi Global gene expression response of a population exposed to benzene: a pilot study exploring the use of RNA-sequencing technology
    Reuben Thomas
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Environ Mol Mutagen 54:566-73. 2013
    ..Overall, this pilot study shows that RNA-seq can complement the information obtained by microarray in the analysis of changes in transcript expression from chemical exposures...
  53. ncbi Analysis of the transcriptome in molecular epidemiology studies
    Cliona M McHale
    Division of Environmental Health Sciences, Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Mol Mutagen 54:500-17. 2013
    ..Analysis of datasets at the pathway level can compensate for some of the limitations of RNA-Seq and, as more datasets become available, will increasingly elucidate the exposure-disease continuum...
  54. pmc Single molecule quantitation and sequencing of rare translocations using microfluidic nested digital PCR
    Joe Shuga
    School of Public Health, University of California, Berkeley, CA 94720, USA, Department of Chemistry, University of California, Berkeley, CA 94720, USA, Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA, UC San Francisco UC Berkeley Graduate Program in Bioengineering, University of California, Berkeley, CA 94720, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20852, USA, Guangdong Poison Control Center, Guangzhou 510300, China and Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, NL 3508, The Netherlands
    Nucleic Acids Res 41:e159. 2013
    ..In this manner, we created a quantitative map for this carcinogenic mutation in this healthy population and identified the positions on chromosomes 14 and 18 where the vast majority of these t(14;18) events occur...
  55. pmc Tobacco smoke exposure and the risk of childhood acute lymphoblastic and myeloid leukemias by cytogenetic subtype
    Catherine Metayer
    School of Public Health, University of California, 1995 University Avenue, Suite 460, Berkeley, CA94704 7392, USA
    Cancer Epidemiol Biomarkers Prev 22:1600-11. 2013
    ....
  56. pmc Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics
    Anand P Chokkalingam
    Division of Epidemiology, School of Public Health, University of California, 1995 University Ave, Ste 460, Berkeley, CA, 94704, USA
    Cancer Causes Control 24:1789-95. 2013
    ..Future studies should examine whether the observed effects vary by environmental, immunological, or lifestyle factors...
  57. pmc Case-control study of arsenic in drinking water and kidney cancer in uniquely exposed Northern Chile
    Catterina Ferreccio
    Departamento de Salud Publica, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Epidemiol 178:813-8. 2013
    ..Odds ratios were not elevated for renal cell cancer. With these new findings, including evidence of dose-response, we believe there is now sufficient evidence in humans that drinking-water arsenic causes renal pelvis and ureter cancer. ..
  58. pmc Fetal growth and childhood acute lymphoblastic leukemia: findings from the childhood leukemia international consortium
    Elizabeth Milne
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, WA, Australia, On behalf of the Aus ALL Consortium Australia
    Int J Cancer 133:2968-79. 2013
    ..The evidence that accelerated fetal growth is associated with a modest increased risk of childhood ALL is strong and consistent with known biological mechanisms involving insulin-like growth factors. © 2013 UICC. ..
  59. ncbi Characterization of four TCE-dechlorinating microbial enrichments grown with different cobalamin stress and methanogenic conditions
    Yujie Men
    Department of Civil and Environmental Engineering, University of California, 207 O Brien Hall, Berkeley, CA 94720 1710, USA
    Appl Microbiol Biotechnol 97:6439-50. 2013
    ..In contrast, acetogenic bacteria that were abundant in the enrichments, such as PDS and Clostridium sp., may be potential corrinoid providers for Dhc...
  60. pmc Chronic respiratory symptoms in children following in utero and early life exposure to arsenic in drinking water in Bangladesh
    Allan H Smith
    Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, USA, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh, Department of Medicine, University of California, San Francisco, CA, USA, Department of Community Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA, USA, Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA and Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, USA
    Int J Epidemiol 42:1077-86. 2013
    ..Arsenic exposure via drinking water increases the risk of chronic respiratory disease in adults. However, information on pulmonary health effects in children after early life exposure is limited...
  61. pmc Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides
    Daniel Medina-Cleghorn
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 127 Morgan Hall, Berkeley, California 94720, United States
    ACS Chem Biol 9:423-32. 2014
    ....
  62. pmc A genome-wide screen identifies yeast genes required for tolerance to technical toxaphene, an organochlorinated pesticide mixture
    Brandon D Gaytán
    Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California, United States of America
    PLoS ONE 8:e81253. 2013
    ..Many of the yeast genes identified in this study have human homologs, warranting further investigations into the potentially conserved mechanisms of toxaphene toxicity. ..
  63. ncbi Are urinary PAHs biomarkers of controlled exposure to diesel exhaust?
    Sixin S Lu
    College of Natural Resources, University of California, Berkeley, CA, USA
    Biomarkers 19:332-9. 2014
    ..DE exposures did not significantly alter urinary PAH levels. We conclude that urinary PAHs are not promising biomarkers of short-term exposures to DE in the range of 106-276 µg/m(3)...
  64. pmc Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi
    Wei Qin Zhuang
    Department of Civil and Environmental Engineering, University of California, Berkeley, CA 94720 1710
    Proc Natl Acad Sci U S A 111:6419-24. 2014
    ..mccartyi indicates a unique bacterial C1 metabolism that is critical for D. mccartyi growth and interactions in dechlorinating communities and may play a role in other anaerobic communities. ..
  65. pmc Potential role of selection bias in the association between childhood leukemia and residential magnetic fields exposure: a population-based assessment
    Danna A Slusky
    School of Public Health, University of California, Berkeley, CA, United States Electronic address
    Cancer Epidemiol 38:307-13. 2014
    ....
  66. pmc Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia
    Patrick J Morris
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 127 Morgan Hall, Berkeley, California 94720, United States
    ACS Chem Biol 9:1097-103. 2014
    ..Our findings suggest novel toxicities that may arise from OPFR exposure and highlight the utility of chemoproteomic and metabolomic platforms in the toxicological characterization of environmental chemicals. ..
  67. pmc Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human
    Cliona M McHale
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California
    Ann N Y Acad Sci 1310:74-83. 2014
    ..In this review, we describe our comprehensive toxicogenomic approach and the potential mechanisms of toxicity and susceptibility genes identified for benzene and formaldehyde, as well as related studies conducted by other researchers. ..
  68. pmc The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia
    Adam J de Smith
    Department of Epidemiology and Biostatistics and
    Blood 123:2497-503. 2014
    ..93; 95% CI, 1.44-12.64). Our findings suggest a role for KIR genes and their HLA ligands in childhood ALL etiology that may vary among ethnic groups. ..
  69. pmc Sustainable growth of Dehalococcoides mccartyi 195 by corrinoid salvaging and remodeling in defined lactate-fermenting consortia
    Yujie Men
    Department of Civil and Environmental Engineering, University of California, Berkeley, California, USA
    Appl Environ Microbiol 80:2133-41. 2014
    ..These findings provide insights into both the gene regulation of corrinoid salvaging and remodeling in Dhc195 when it is grown without exogenous cobalamin and microbe-to-microbe interactions in dechlorinating microbial communities. ..
  70. pmc Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke
    Matthew North
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720, USA
    BMC Cancer 14:6. 2014
    ..Increased Ras signaling is implicated as a causal factor in the increased pre-disposition to leukemia of individuals with mutations in NF1...
  71. pmc Isotope effect of mercury diffusion in air
    Paul G Koster van Groos
    Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, California, 94720 United States of America
    Environ Sci Technol 48:227-33. 2014
    ..The measured relative atomic diffusivities among mercury isotopes in air are large and in agreement with kinetic gas theory. Mercury diffusion in air offers a reasonable explanation of recent field results reported in the literature. ..
  72. pmc Polychlorinated biphenyls in residential dust: sources of variability
    Todd P Whitehead
    University of California, Berkeley, School of Public Health, 50 University Hall MC 7360, Berkeley, California 94720, United States
    Environ Sci Technol 48:157-64. 2014
    ..Our findings suggest that it may be feasible to use residential dust for retrospective assessment of PCB exposures in studies of children's health. ..
  73. pmc Blood levels of folate at birth and risk of childhood leukemia
    Anand P Chokkalingam
    UC Berkeley School of Public Health, 1995 University Ave, Ste 460, Berkeley CA 94704, USA
    Cancer Epidemiol Biomarkers Prev 22:1088-94. 2013
    ..Previous case-control studies examining the association between risk of childhood acute lymphoblastic leukemia (ALL) and mothers' self-reported folate intake and supplementation have been inconclusive...
  74. ncbi Occurrence of trivalent monomethyl arsenic and other urinary arsenic species in a highly exposed juvenile population in Bangladesh
    David A Kalman
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA
    J Expo Sci Environ Epidemiol 24:113-20. 2014
    ..The low urinary concentrations in highly exposed individuals and known difficulties in preserving sample oxidation state indicate that urinary MMA(III) is not suitable for use as an epidemiological biomarker. ..
  75. pmc HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk
    Kevin Y Urayama
    School of Public Health, University of California, Berkeley, CA 94704, USA
    Blood 120:3039-47. 2012
    ..These findings support an immune mechanism in the etiology of childhood ALL involving the HLA-DPB1 gene in the context of an insufficiently modulated immune system...
  76. pmc Versatility in corrinoid salvaging and remodeling pathways supports corrinoid-dependent metabolism in Dehalococcoides mccartyi
    Shan Yi
    Department of Civil and Environmental Engineering, University of California, Berkeley, California, USA
    Appl Environ Microbiol 78:7745-52. 2012
    ..This study of corrinoid utilization and modification by D. mccartyi provides insight into the array of strategies that microorganisms employ in acquiring essential nutrients from the environment...
  77. pmc Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemia
    Anand P Chokkalingam
    School of Public Health, University of California Berkeley, Berkeley, CA, USA
    Cancer Causes Control 23:1577-85. 2012
    ..Additional studies are needed to confirm these findings and identify specific causal variants...
  78. pmc Gold nanoparticle films as sensitive and reusable elemental mercury sensors
    Jay Z James
    Department of Mechanical Engineering, University of California at Berkeley, Berkeley, California 94720, United States
    Environ Sci Technol 46:9557-62. 2012
    ..Regeneration of the sensing films, done by heating to 160 °C, allows for repeatable measurements on the same film...
  79. pmc Occupational exposure to formaldehyde and alterations in lymphocyte subsets
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Am J Ind Med 56:252-7. 2013
    ..Formaldehyde is used in many occupational settings, most notably in manufacturing, health care, and embalming. Formaldehyde has been classified as a human carcinogen, but its mechanism of action remains uncertain...
  80. ncbi Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate
    Michele Fromowitz
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Environ Mol Mutagen 53:488-91. 2012
    ..In vitro assays, such as the in vitro micronucleus assay, will be essential as international chemical policy is increasingly utilizing green chemistry principles that require more toxicological testing...
  81. pmc Genome-wide functional profiling identifies genes and processes important for zinc-limited growth of Saccharomyces cerevisiae
    Matthew North
    Department of Nutritional Science and Toxicology, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 8:e1002699. 2012
    ..Thus, functional profiling has provided many new insights into genes and processes that are needed for cells to thrive under the stress of zinc deficiency...
  82. pmc Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia
    Anand P Chokkalingam
    Division of Epidemiology, UC Berkeley School of Public Health, University of California Berkeley, 1995 University Ave, Berkeley, CA 94704, USA
    Cancer Causes Control 23:1367-75. 2012
    ..We sought to evaluate the role of genes involved in xenobiotic transport and metabolism in childhood ALL risk, both alone and in conjunction with household chemical exposures previously found to be associated with childhood ALL risk...
  83. pmc Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene
    Roel Vermeulen
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Carcinogenesis 33:1538-41. 2012
    ..The findings suggest that at relatively low occupational exposure levels a toxic effect on the kidneys can be observed. This finding supports the biological plausibility of linking TCE exposure and renal cancer...
  84. ncbi Micronutrients intake is associated with improved sperm DNA quality in older men
    Thomas E Schmid
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Fertil Steril 98:1130-7.e1. 2012
    ..To investigate whether lifestyle factors such as increased dietary intake of micronutrients reduce the risks of sperm DNA damage, and whether older men benefit more than younger men...
  85. pmc Mortality in young adults following in utero and childhood exposure to arsenic in drinking water
    Allan H Smith
    Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, Berkeley, California 94720 7360, USA
    Environ Health Perspect 120:1527-31. 2012
    ..Evidence of increased mortality from lung cancer, bronchiectasis, myocardial infarction, and kidney cancer has been reported among young adults who were in utero or children during the high-exposure period...
  86. pmc Elemental composition of human semen is associated with motility and genomic sperm defects among older men
    Thomas E Schmid
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Hum Reprod 28:274-82. 2013
    ..Older men tend to have poorer semen quality and are generally at higher risks for infertility and abnormal reproductive outcomes...
  87. ncbi Isolation of two new Dehalococcoides mccartyi strains with dissimilar dechlorination functions and their characterization by comparative genomics via microarray analysis
    Patrick K H Lee
    Department of Civil and Environmental Engineering, University of California, Berkeley, CA 94720, USA
    Environ Microbiol 15:2293-305. 2013
    ....
  88. pmc Functional profiling discovers the dieldrin organochlorinated pesticide affects leucine availability in yeast
    Brandon D Gaytán
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720, USA
    Toxicol Sci 132:347-58. 2013
    ..Many yeast genes described in this study have human orthologs that may modulate dieldrin toxicity in humans...
  89. pmc Drinking water arsenic in northern chile: high cancer risks 40 years after exposure cessation
    Craig M Steinmaus
    University of California, Berkeley, School of Public Health, 50 University Hall, MC7360, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 22:623-30. 2013
    ..Because of its unique geology, limited water sources, and good historical records, lifetime exposure and long-term latency patterns can be assessed in this area with better accuracy than in other arsenic-exposed areas worldwide...
  90. ncbi Exposure to herbicides in house dust and risk of childhood acute lymphoblastic leukemia
    Catherine Metayer
    School of Public Health, University of California, Berkeley, California, USA
    J Expo Sci Environ Epidemiol 23:363-70. 2013
    ..No other herbicides were identified as risk factors of childhood ALL. The data suggest that home dust levels of chlorthal, and possibly alachlor, are associated with increased risks of childhood ALL...
  91. pmc BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis
    N Sermondade
    Service d Histologie Embryologie Cytogénétique CECOS, Hopital Jean Verdier AP HP, Bondy, France
    Hum Reprod Update 19:221-31. 2013
    ..The main limitation of this report is that studied populations varied, with men recruited from both the general population and infertile couples. Whether weight normalization could improve sperm parameters should be evaluated further...
  92. pmc Low-dose metabolism of benzene in humans: science and obfuscation
    Stephen M Rappaport
    Superfund Research Program and Center for Exposure Biology, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 34:2-9. 2013
    ..In addressing these criticisms, we show that the methods and arguments presented by Price et al. are scientifically unsound and that their results are unreliable...
  93. pmc Characterization of residential pesticide use and chemical formulations through self-report and household inventory: the Northern California Childhood Leukemia study
    Neela Guha
    School of Public Health, University of California at Berkeley, Berkeley, California, USA
    Environ Health Perspect 121:276-82. 2013
    ..Exposure has generally been self-reported, so the assessment is potentially limited by recall bias and lack of information on specific chemicals...
  94. pmc Kinetics and efficiency of H2O2 activation by iron-containing minerals and aquifer materials
    Anh Le Tuan Pham
    Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, CA 94720 1710, USA
    Water Res 46:6454-62. 2012
    ..In addition, the presence of 2 mM of dissolved SiO(2) slowed the rate of H(2)O(2) decomposition on aquifer materials by over 80% without affecting the stoichiometric efficiency...
  95. pmc Metagenomic analysis of a stable trichloroethene-degrading microbial community
    Vanessa L Brisson
    Department of Civil and Environmental Engineering, University of California Berkeley, CA 94720, USA
    ISME J 6:1702-14. 2012
    ..Genes for hydrogenase components (271 in total) were widespread, highlighting the importance of hydrogen metabolism in this community. PhyloChip analysis confirmed the stability of this microbial community...

Research Grants30

  1. DETECTION AND MODELS OF TOXICANT EXPOSURE
    Robert H Tukey; Fiscal Year: 2013
    ..Our combined efforts are anticipated to provide new insights into the molecular mechanisms that lead to environmental illness, and improve our understanding of the consequences of exposure to Superfund site contaminants. ..
  2. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
    ..We plan to build research capacity in the Center and other organizations, enhance careers of new investigators, and make key findings accessible to researchers, policy makers, practitioners, and the public. ..
  3. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
    ..This Program is highly relevant to Superfund by addressing high-priority chemicals and by focusing on mechanisms underlying health effects, exposure assessment, and remediation to mitigate exposure and toxicity. ..
  4. BIOMARKERS OF EXPOSURE TO HAZARDOUS SUBSTANCES
    Bruce D Hammock; Fiscal Year: 2013
    ..abstract_text> ..
  5. Superfund Metal Mixtures, Biomarkers and Neurodevelopment
    David C Bellinger; Fiscal Year: 2013
    ..Aim 4- To promote rapid dissemination of significant research findings;and Aim 5- Compliance- To ensure compliance with NIH requirements for data and resource-sharing and the human and animal institutional review board requirements ..
  6. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..These data and dietary studies in the last Aim will provide a scientific basis for risk assessment and advice for stakeholders with the ultimate goal to protect highly-exposed individuals and populations. ..
  7. PAHs: New Technologies and Emerging Health Risks
    David E Williams; Fiscal Year: 2013
    ..Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities. ..