Center for Interdisciplinary Research on Nicotine Addiction (CIRNA)

Summary

Principal Investigator: Caryn Lerman
Abstract: Abstinence from smoking produces aversive symptoms that prompt relapse, often within the first week following a quit attempt. Clarifying the neurobiological and behavioral underpinnings of these early abstinence symptoms is, therefore, critical to develop more efficacious treatments. The proposed Center for Interdisciplinary Research on Nicotine Addiction (CIRNA) extends nine years of research conducted in the Transdisciplinary Tobacco Use Research Center (TTURC) at UPENN. Spanning from preclinical to clinical studies, CIRNA includes a highly interactive set of projects and cores that seek to: (1) discover the cellular, molecular, neural, and behavioral basis of early nicotine abstinence effects that contribute to relapse;(2) identify brain and behavioral mechanisms through which efficacious therapies modulate these processes;and (3) validate novel medication screening approaches. Project 1 uses neurobiology and pharmacology to elucidate the molecular and behavioral basis of emotional and cognitive symptoms of nicotine abstinence and re-exposure in a mouse model. Project 2 uses electrophysiology and pharmacology to explore the effects of nicotine abstinence and re-exposure on sensory processing in key brain regions in mice. Project 3 uses human neuroimaging to examine the neural substrates of early abstinence symptoms and medication response. Project 4 extends this work by validating novel approaches to improve the sensitivity of early human medication screening paradigms for nicotine dependence. Shared resources, including an Administrative Core, a Data Management and Biostatistics Core, and a Biospecimen Core provide value-added, as well as support for a comprehensive data sharing plan. A Career Development Core promotes involvement of post-doctoral fellows and junior investigators in these projects, and supports pilot projects to facilitate career development. Thus, the CIRNA addresses the clinically important problem of nicotine dependence using innovative multidisciplinary approaches, with the ultimate goal of developing more efficacious medications for tobacco dependence and prevention of tobacco-related disease. The CIRNA is proposed to replace the TTURC, since this NIH initiative is ending.
Funding Period: 2009-08-01 - 2014-07-31
more information: NIH RePORT

Top Publications

  1. ncbi Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal
    Rebecca L Ashare
    University of Pennsylvania, Perelman School of Medicine, Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, 3535 Market St, Suite 4100, Philadelphia, PA 19104, USA 1 215 746 5789
    Expert Opin Drug Discov 9:579-94. 2014
  2. pmc Optimal carbon monoxide criteria to confirm 24-hr smoking abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 15:978-82. 2013
  3. pmc Possible reinforcement enhancing effects of bupropion during initial smoking abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 15:1141-5. 2013
  4. pmc Effects of chronic low- and high-dose nicotine on cognitive flexibility in C57BL/6J mice
    Leonardo A Ortega
    Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA 19122, United States
    Behav Brain Res 238:134-45. 2013
  5. pmc Assessing the fit of parametric cure models
    E Paul Wileyto
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biostatistics 14:340-50. 2013
  6. pmc The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence
    Andrew W Bergen
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Nicotine Tob Res 15:1190-200. 2013
  7. pmc Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats
    Blake A Kimmey
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Addict Biol 19:539-51. 2014
  8. pmc APOE ɛ4, an Alzheimer's disease susceptibility allele, and smoking cessation
    R L Ashare
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Pharmacogenomics J 13:538-43. 2013
  9. pmc The effect of menthol on cigarette smoking behaviors, biomarkers and subjective responses
    Andrew A Strasser
    Corresponding Author Andrew A Strasser, Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Cancer Epidemiol Biomarkers Prev 22:382-9. 2013
  10. pmc Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain
    G Patrick Hussmann
    Department of Pharmacology and Physiology, Georgetown University School of Medicine, 3900 Reservoir Road, NW, Washington, DC 20057, USA
    J Pharmacol Exp Ther 343:441-50. 2012

Research Grants

  1. UAB / UMN SPORE in Pancreatic Cancer
    Donald J Buchsbaum; Fiscal Year: 2013
  2. Signaling in Inflammation, Stress, and Tumorigenesis
    GEORGE ROBERT STARK; Fiscal Year: 2013

Detail Information

Publications81

  1. ncbi Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal
    Rebecca L Ashare
    University of Pennsylvania, Perelman School of Medicine, Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, 3535 Market St, Suite 4100, Philadelphia, PA 19104, USA 1 215 746 5789
    Expert Opin Drug Discov 9:579-94. 2014
    ..Thus, pharmacotherapies that increase cognitive performance during nicotine withdrawal may represent potential smoking cessation agents...
  2. pmc Optimal carbon monoxide criteria to confirm 24-hr smoking abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 15:978-82. 2013
    ..Smoking cessation is typically verified biochemically by expired-air carbon monoxide (CO) levels below 9 ppm (i.e., ≤8 ppm), but this CO criterion may lead many who have smoked within 24hr to be misclassified as abstinent...
  3. pmc Possible reinforcement enhancing effects of bupropion during initial smoking abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 15:1141-5. 2013
    ..Recent rodent research suggests that bupropion may reverse this attenuation, perhaps helping explain its efficacy in aiding cessation...
  4. pmc Effects of chronic low- and high-dose nicotine on cognitive flexibility in C57BL/6J mice
    Leonardo A Ortega
    Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA 19122, United States
    Behav Brain Res 238:134-45. 2013
    ..Moreover, striatal BDNF may play a critical role in nicotine-induced alterations in cognitive flexibility...
  5. pmc Assessing the fit of parametric cure models
    E Paul Wileyto
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biostatistics 14:340-50. 2013
    ..We derive the asymptotic distribution of the residuals and evaluate their performance by simulation in a range of parametric models. We apply our approach to data from a smoking cessation drug trial...
  6. pmc The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence
    Andrew W Bergen
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Nicotine Tob Res 15:1190-200. 2013
    ....
  7. pmc Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats
    Blake A Kimmey
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Addict Biol 19:539-51. 2014
    ..Collectively, these results indicate that increased extracellular acetylcholine levels are sufficient to attenuate nicotine taking and seeking in rats and that these effects are not due to adverse malaise symptoms such as nausea. ..
  8. pmc APOE ɛ4, an Alzheimer's disease susceptibility allele, and smoking cessation
    R L Ashare
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Pharmacogenomics J 13:538-43. 2013
    ..An increased understanding of the underlying pathophysiological mechanisms of this association could facilitate the development of targeted therapies for smokers with increased risk for cognitive decline. ..
  9. pmc The effect of menthol on cigarette smoking behaviors, biomarkers and subjective responses
    Andrew A Strasser
    Corresponding Author Andrew A Strasser, Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Cancer Epidemiol Biomarkers Prev 22:382-9. 2013
    ....
  10. pmc Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain
    G Patrick Hussmann
    Department of Pharmacology and Physiology, Georgetown University School of Medicine, 3900 Reservoir Road, NW, Washington, DC 20057, USA
    J Pharmacol Exp Ther 343:441-50. 2012
    ....
  11. pmc Cue reactivity as a predictor of successful abstinence initiation among adult smokers
    Cynthia A Conklin
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 20:473-8. 2012
    ..Implications of these seemingly counterintuitive findings are discussed...
  12. pmc Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: a pilot feasibility study
    Rebecca L Ashare
    University of Pennsylvania Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 126:263-7. 2012
    ..This pilot feasibility study tested whether an AChEI, donepezil, enhanced cognitive performance among healthy smokers...
  13. pmc Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats
    Thomas J Hopkins
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 37:2310-21. 2012
    ....
  14. pmc Effects of 21 days of varenicline versus placebo on smoking behaviors and urges among non-treatment seeking smokers
    Rebecca L Ashare
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    J Psychopharmacol 26:1383-90. 2012
    ..Results have important treatment implications because changes in CPD and craving did not occur until after the typical one-week run-up period. This suggests that a longer duration of pre-treatment may be beneficial for some smokers...
  15. pmc Graphic warning labels in cigarette advertisements: recall and viewing patterns
    Andrew A Strasser
    Center for Interdisciplinary Research on Nicotine Addiction, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3309, USA
    Am J Prev Med 43:41-7. 2012
    ..The FDA requires that these graphic warning labels be embedded into cigarette advertising and packaging by September 2012...
  16. pmc Negative mood effects on craving to smoke in women versus men
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 152123, USA
    Addict Behav 38:1527-31. 2013
    ..These results suggest that very acute negative mood situations (e.g. just a few minutes in Study 2), and perhaps overnight abstinence, may increase craving to smoke to a greater extent in women relative to men...
  17. pmc Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus
    Justin W Kenney
    Department of Psychology, Temple University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e39939. 2012
    ....
  18. pmc Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice
    MONICA R F HILARIO
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuropsychopharmacology 37:2661-70. 2012
    ..Together, these data suggest that a continuing increase in brain reward function and enhanced sensitivity to nicotine reward following repeated withdrawal periods may be one reason why smokers relapse frequently...
  19. pmc Genetic background influences the effects of withdrawal from chronic nicotine on learning and high-affinity nicotinic acetylcholine receptor binding in the dorsal and ventral hippocampus
    Derek S Wilkinson
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, Philadelphia, PA 19122, USA
    Psychopharmacology (Berl) 225:201-8. 2013
    ..If nAChR upregulation underlies withdrawal deficits in learning, then strains of mice exhibiting withdrawal deficits in hippocampus-dependent learning should also show upregulation of hippocampal nAChRs...
  20. pmc Translational research in nicotine dependence
    Jill R Turner
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cold Spring Harb Perspect Med 3:a012153. 2013
    ..This article reviews translational studies targeting manipulations of the cholinergic system as a viable therapeutic target for nicotine addiction...
  21. pmc Age-related differences in working memory deficits during nicotine withdrawal
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Addict Biol 19:907-17. 2014
    ....
  22. pmc Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
    Thomas J Gould
    Temple University Department of Psychology, Neuroscience Program, Temple University, Philadelphia, PA 19122, United States Electronic address
    Neurobiol Learn Mem 107:108-32. 2014
    ..e., adolescence) in these effects. ..
  23. pmc Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence
    J R Turner
    Department of Pharmacology, Translational Research Laboratories, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Mol Psychiatry 19:801-10. 2014
    ..Although the function of the SNP in NRG3 in humans is not known, these data suggest that Nrg3/ErbB4 signaling may be an important factor in nicotine dependence. ..
  24. pmc An efficient early phase 2 procedure to screen medications for efficacy in smoking cessation
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA, 15213, USA
    Psychopharmacology (Berl) 231:1-11. 2014
    ..e., Food and Drug Administration (FDA) early phase 2), such as in aiding smoking cessation, should be efficient in identifying which drugs do, or do not, warrant more extensive (and expensive) clinical testing...
  25. pmc Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear
    Thomas J Gould
    Department of Psychology, Weiss Hall, Neuroscience Program, Temple University, Philadelphia, PA 19122, USA Electronic address
    Brain Res 1559:1-10. 2014
    ..These findings are discussed in terms of implications for development of therapeutics that target symptoms of nicotine addiction and for theories of addiction...
  26. pmc The association between changes in alternative reinforcers and short-term smoking cessation
    Patricia M Goelz
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States Electronic address
    Drug Alcohol Depend 138:67-74. 2014
    ..This study examined the behavioral economics of smoking cessation within a smoking cessation clinical trial and evaluated how depressive symptoms and behavioral economic variables are associated with smoking cessation...
  27. pmc Large-scale brain network coupling predicts acute nicotine abstinence effects on craving and cognitive function
    Caryn Lerman
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia
    JAMA Psychiatry 71:523-30. 2014
    ..Interactions of large-scale brain networks may underlie cognitive dysfunctions in psychiatric and addictive disorders...
  28. pmc Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors
    Nicole L Yohn
    Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    J Pharmacol Exp Ther 349:348-54. 2014
    ..Together, these studies identify additional nAChR partial agonists that may aid in the rational development of smoking cessation aids. ..
  29. pmc A double-blind placebo-controlled randomized trial of varenicline for smokeless tobacco dependence in India
    Raka Jain
    National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India
    Nicotine Tob Res 16:50-7. 2014
    ..This trial evaluated varenicline for treating smokeless tobacco dependence in India...
  30. pmc Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls
    Mary Falcone
    1 Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA 2 Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 38:2327-37. 2013
    ..Future studies that pre-screen participants for genetic variants selected a priori based on drug metabolism and targets have the greatest potential to advance the science and practice of psychiatric treatment. ..
  31. pmc The effects of acute nicotine, chronic nicotine, and withdrawal from chronic nicotine on performance of a cued appetitive response
    Prescott T Leach
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, PA 19122, USA
    Behav Neurosci 127:303-10. 2013
    ..The findings may provide an explanation for higher rates of smoking in patients with impulse control issues, as the smoking may represent an initial attempt at self-medication...
  32. pmc Biomarkers for smoking cessation
    K J Bough
    Division of Pharmacotherapies and Medical Consequences, National Institute on Drug Abuse, Bethesda, Maryland, USA
    Clin Pharmacol Ther 93:526-38. 2013
    ..A preclinical viewpoint is also offered, as are analytical considerations and a regulatory perspective summarizing a pathway toward biomarker qualification...
  33. pmc Divergent functional effects of sazetidine-a and varenicline during nicotine withdrawal
    Jill R Turner
    Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 38:2035-47. 2013
    ..These findings highlight the importance of drug history in understanding the mechanisms through which nicotinic compounds may be aiding smoking cessation in individuals experiencing withdrawal-associated anxiety...
  34. pmc Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment
    Rebecca L Ashare
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA Electronic address
    Neuropharmacology 76:581-91. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  35. pmc The first 7 days of a quit attempt predicts relapse: validation of a measure for screening medications for nicotine dependence
    Rebecca L Ashare
    From the Department of Psychiatry RLA and RAS, University of Pennsylvania Perelman School of Medicine, Philadelphia Department of Biostatistics and Epidemiology EPW and Abramson Cancer Center RAS, University of Pennsylvania, Philadelphia and Department of Psychiatry KAP, University of Pittsburgh, Pittsburgh, PA
    J Addict Med 7:249-54. 2013
    ..We tested the number of days of abstinence during the first week after the target quit date (TQD) as a predictor of point prevalence abstinence in 3 independent pharmacotherapy trials for nicotine dependence...
  36. pmc Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine self-administration
    Pavel I Ortinski
    Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:9451-61. 2013
    ..These findings outline a pattern of adaptive interactions between D1DRs and NMDARs in the nucleus accumbens shell and demonstrate upregulation of extrasynaptic NMDAR signaling as a novel consequence of cocaine self-administration...
  37. pmc Effects of bupropion on cognitive performance during initial tobacco abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA Electronic address
    Drug Alcohol Depend 133:283-6. 2013
    ..We examined whether bupropion would attenuate abstinence-induced cognitive deficits on the first day of a brief quit attempt, when smokers are most likely to relapse...
  38. pmc Sensitivity and specificity of a procedure for early human screening of novel smoking cessation medications
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Addiction 108:1962-8. 2013
    ..A method has been developed that detects efficacy of varenicline and nicotine patch. This study aimed to evaluate whether the method would detect the efficacy of bupropion and identify correctly the lack of efficacy of modafinil...
  39. pmc High dose transdermal nicotine for fast metabolizers of nicotine: a proof of concept placebo-controlled trial
    Robert A Schnoll
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nicotine Tob Res 15:348-54. 2013
    ..Thus, faster metabolizers of nicotine may require a higher nicotine patch dose to achieve cessation...
  40. pmc Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 97:482-94. 2012
    ....
  41. pmc Running-induced anxiety is dependent on increases in hippocampal neurogenesis
    J L Onksen
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Genes Brain Behav 11:529-38. 2012
    ..However, both the neurogenic and anxiogenic effects of wheel running were attenuated following hippocampal ATR deletion, suggesting that increased neurogenesis is an important mediator of exercise-induced anxiety...
  42. pmc The role of nicotinic acetylcholine receptors in the medial prefrontal cortex and hippocampus in trace fear conditioning
    J D Raybuck
    Department of Behavioral Neuroscience, L470, 3181 Sam Jackson RD, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neurobiol Learn Mem 94:353-63. 2010
    ....
  43. pmc Increased self-efficacy to quit and perceived control over withdrawal symptoms predict smoking cessation following nicotine dependence treatment
    Robert A Schnoll
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Addict Behav 36:144-7. 2011
    ....
  44. pmc Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline
    Jill R Turner
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 13:41-6. 2011
    ..Clinical and preclinical studies suggest that regulation of nicotinic acetylcholine receptors (nAChR) maybe involved in the etiology of withdrawal symptoms...
  45. pmc Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus
    Jessica M Andre
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neuropharmacology 60:617-25. 2011
    ....
  46. pmc Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level
    Andrew A Strasser
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104 3309, USA
    Cancer Epidemiol Biomarkers Prev 20:234-8. 2011
    ..We hypothesized that faster NMR would be associated with greater cigarette puff volume and higher levels of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a carcinogen biomarker...
  47. pmc Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect
    Jennifer L Onksen
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuropsychopharmacology 36:960-9. 2011
    ..Furthermore, attenuated capacity for synaptic remodeling may underlie these behaviors. ATR deletion may serve as a valuable model to study the various proposed roles of newborn neurons in the hippocampus...
  48. ncbi Cross-validation of a new procedure for early screening of smoking cessation medications in humans
    K A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 88:109-14. 2010
    ..These data confirm the feasibility of a brief, sensitive test of the efficacy of cessation medications in smokers with high quit interest...
  49. pmc Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior
    Jill R Turner
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Pharmacol Exp Ther 334:665-72. 2010
    ..These results suggest that the partial agonists varenicline and sazetidine-A may have diverse therapeutic benefits in affective disorders...
  50. pmc Nicotine patch vs. nicotine lozenge for smoking cessation: an effectiveness trial coordinated by the Community Clinical Oncology Program
    Robert A Schnoll
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, 4th Floor, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 107:237-43. 2010
    ..This study compared the effectiveness of transdermal nicotine vs. nicotine lozenge for smoking cessation and identified predictors of treatment response...
  51. pmc OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models
    Stephen D Mague
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, TRL, PA 19104, USA
    Drug Alcohol Depend 108:172-82. 2010
    ..Evaluation of models that incorporate known human genetic variants into a tractable system, like the mouse, will facilitate the understanding of discrete contributions of SNPs to human disease...
  52. pmc Effectiveness of extended-duration transdermal nicotine therapy: a randomized trial
    Robert A Schnoll
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Ann Intern Med 152:144-51. 2010
    ..Tobacco dependence is a chronic, relapsing condition that may require extended treatment...
  53. pmc Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence
    Riju Ray
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 35:1374-82. 2010
    ..Additional sequencing and characterization of ChAT may reveal functional variants that contribute to nicotine dependence and smoking cessation...
  54. ncbi Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 67:715-21. 2010
    ..In rodents and humans, cognitive deficits can be reversed by treatment with the alpha4beta2 nicotinic receptor partial agonist varenicline. This neuroimaging study examined the neural mechanisms that underlie these effects...
  55. pmc Varenicline's effects on acute smoking behavior and reward and their association with subsequent abstinence
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 210:45-51. 2010
    ..We compared the effects of varenicline versus placebo on smoking behavior and reward, assessed both prospectively and retrospectively, and related these effects to subsequent success in a brief simulated quit attempt with medication...
  56. pmc Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy
    C Lerman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 87:553-7. 2010
    ..RMs of nicotine are candidates for extended transdermal nicotine therapy, whereas an alternative therapeutic approach may be needed for those with normal rates of nicotine metabolism...
  57. pmc Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 13:498-503. 2011
    ..We tested the potential interacting effects of these two risk factors on CPD...
  58. pmc Graphic-enhanced information improves perceived risks of cigar smoking
    Andrew A Strasser
    Center for Interdisciplinary Research on Nicotine Addiction, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
    Addict Behav 36:865-9. 2011
    ..Utilizing graphics on health information internet pages can increase knowledge and perceived risks of cigar smoking...
  59. pmc Subjective reactivity to smoking cues as a predictor of quitting success
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 14:383-7. 2012
    ..e., "cue reactivity") is often believed to identify those less able to later quit smoking. Although absolute craving level can predict smoking behavior, smoking cue reactivity per se may not predict cessation outcome...
  60. pmc Extended duration therapy with transdermal nicotine may attenuate weight gain following smoking cessation
    Robert A Schnoll
    Department of Psychiatry, Abramson Cancer Center, and Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA 19104, United States
    Addict Behav 37:565-8. 2012
    ..This study evaluated whether extended vs. standard duration treatment with nicotine patch helps those able to quit smoking to reduce cessation-induced weight gain and explored nicotine patch adherence as a mediator of treatment effects...
  61. pmc Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning
    Justin W Kenney
    Department of Psychology, Temple University, Weiss Hall, Philadelphia, Pennsylvania 19122, USA
    Hippocampus 22:1681-90. 2012
    ..These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning...
  62. pmc The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, 6th Floor, Philadelphia, PA 19122, USA
    Neuropharmacology 62:2118-25. 2012
    ..Thus, nicotine withdrawal-related deficits in contextual learning are time-limited changes that are associated with temporal changes in upregulation of high-affinity nAChR binding...
  63. pmc Comparison of the performance of DBA/2 and C57BL/6 mice in transitive inference and foreground and background contextual fear conditioning
    Jessica M Andre
    Department of Psychology, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Behav Neurosci 126:249-57. 2012
    ..These results demonstrate that the DBA/2 mice have deficits in higher-cognitive processes and suggest that similar substrates may underlie deficits in contextual learning and transitive inference...
  64. pmc Comparative dynamics of four smoking withdrawal symptom scales
    Harold S Javitz
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Addiction 107:1501-11. 2012
    ....
  65. pmc Pharmacogenetic association of the galanin receptor (GALR1) SNP rs2717162 with smoking cessation
    Allison B Gold
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 37:1683-8. 2012
    ..04). In the bupropion trial, smokers carrying the C allele also reported more severe TQD cravings. Further research to identify functional variants in GALR1 and to replicate pharmacogenetic associations is warranted...
  66. pmc μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 222:701-8. 2012
    ..The perception that smoking relieves negative affect contributes to smoking persistence. Endogenous opioid neurotransmission, and the μ-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine...
  67. pmc Biomarkers to optimize the treatment of nicotine dependence
    Robert A Schnoll
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Presbyterian Medical Center 1 PHI, 51 N 39th Street, Philadelphia, PA 19104, USA
    Biomark Med 5:745-61. 2011
    ..Barriers to the translation of this research to clinical practice are discussed, as are directions for future research...
  68. pmc Addiction and cognition
    Thomas J Gould
    Department of Psychology and Center for Substance Abuse Research, Temple University, Philadelphia, Pennsylvania 19122, USA
    Addict Sci Clin Pract 5:4-14. 2010
    ..Patients with mental illness are at high risk for substance abuse, and the adverse impact on cognition may be particularly deleterious in combination with cognitive problems related to their mental disorders...
  69. pmc The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J mice
    Justin W Kenney
    Department of Psychology, Temple University, Weiss Hall, 1701 N 13th St, Philadelphia, PA 19122, USA
    Psychopharmacology (Berl) 217:353-65. 2011
    ..While this type of learning occurs on a daily basis, little is known about how nicotine administration affects it...
  70. ncbi The dynamics of the urge-to-smoke following smoking cessation via pharmacotherapy
    Harold S Javitz
    SRI International, Menlo Park, CA 94025, USA
    Addiction 106:1835-45. 2011
    ..To examine person-specific urge-to-smoke trajectories during the first 7 days of abstinence and the relationship of trajectory parameters to continuous abstinence, demographics, medication and smoking history...
  71. pmc Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers
    Riju Ray
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:9268-73. 2011
    ..Future translational investigations can elucidate the role of MORs in nicotine addiction, which may lead to development of novel therapeutics...
  72. pmc A novel recruitment message to increase enrollment into a smoking cessation treatment program: preliminary results from a randomized trial
    Robert A Schnoll
    Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104, USA
    Health Commun 26:735-42. 2011
    ..A larger clinical trial to evaluate a genetic prime message for improving recruitment into smoking cessation programs is warranted...
  73. pmc Strain-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, Philadelphia, PA 19122, USA
    Behav Genet 42:133-50. 2012
    ..The identification of genetic factors that may alter the effects of nicotine on cognition may lead to more efficacious treatments for nicotine addiction...
  74. pmc Is self-efficacy for smoking abstinence a cause of, or a reflection on, smoking behavior change?
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Clin Psychopharmacol 20:56-62. 2012
    ....
  75. pmc Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch
    Kenneth A Perkins
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cancer Epidemiol Biomarkers Prev 18:2608-12. 2009
    ....

Research Grants30

  1. UAB / UMN SPORE in Pancreatic Cancer
    Donald J Buchsbaum; Fiscal Year: 2013
    ..The application has strong institutional support from UAB and UMN, excellent pancreatic cancer populations and concurrence with federal guidelines. ..
  2. Signaling in Inflammation, Stress, and Tumorigenesis
    GEORGE ROBERT STARK; Fiscal Year: 2013
    ..abstract_text> ..