Prevalence of environmental and genetic risk factors for gastric cancer in a popu

Summary

Principal Investigator: LOVELL ALLAN JONES
Abstract: Gastric cancer (GC) can be considered an indicator of health disparity since it is more prevalent in developing countries, where the mortality is higher. In Mexico GC is the 3rd leading cause of mortality after CVD and lung cancer, and in the US, GC incidence is also higher in Hispanics than in white Americans. The etiologic factors for GC include Helicobacter Pylori infection, dietary factors and genetic susceptibility. Due to the large number of MA children residing in Texas, and the high prevalence of gastric disorders observed in our on-going study "Biomarkers of Genetic Susceptibility in Environmentally Exposed Migrant/Seasonal Farmworker Children (MSF Study), we propose to use a molecular and environmental epidemiologic approach to assess the prevalence of the aforementioned GC risk factors among this minority population. In addition, we will develop and validate a FFQ to assess the folate and vitamin B-12 intake of MA children residing in Texas. Our short-term goal is to estimate the magnitude of the prevalence of the social, environmental and genetic factors that have been associated with GC risk among MA children, with the long-term goal of reducing the risk that can be modified through preventive interventions. The specific aims of the study are to: 1. Generate epidemiological and dietary GC risk data from 500 MA children ages 5 to 18. We will obtain socioeconomic and dietary information, family history of GC and gastric disorders (GD), children's medical history and symptoms of GD via a structured bilingual questionnaire using indirect interviewing techniques with the mother and child participants. 2: Genotype a key gene involved in folate-DNA methylation as an intermediate biomarker for GC risk. We will genotype the children for polymorphisms in the methylenetetrahydrofolate reductase (MTHFR gene at position 677C>T since variability in this gene can critically influence the distribution and availability of folate, which in turn can increase the risk for GC. 3: Determine the folate, vitamin B-12 and homocysteine levels of the children. We will analyze the levels of folate in the erythrocytes and the homocysteine in the plasma of the children participants as intermediate biomarkers for GC risk since folate deficiency can lead to an accumulation of homocysteine, which in turn reduces the availability of methyl groups needed for DNA methylation 4. Determine the seroprevalence of antibodies against HP. We will analyze the serum of the children participants for the presence of IgG antibody against HP, which is an indicator of HP exposure, and a risk factor for GC. The ability to identify children are risk for GC, due to either genetic predisposition or environmental factors has substantial implication for cancer prevention. Findings from our study may also serve to reduce existent GC health disparities worldwide and in the U.S.
Funding Period: -------------------- - --------------------
more information: NIH RePORT

Top Publications

  1. ncbi Detection of chromosomal aberrations by fluorescence in situ hybridization in cervicovaginal biopsies from women exposed to diethylstilbestrol in utero
    R A Hajek
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Gynecol Cancer 16:318-24. 2006
  2. ncbi Higher risk for obesity among Mexican-American and Mexican immigrant children and adolescents than among peers in Mexico
    Mariá A Hernández-Valero
    Center for Research on Minority Health, Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA
    J Immigr Minor Health 14:517-22. 2012
  3. pmc Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands
    Jie Tian
    Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, Texas 78957, USA
    Mol Carcinog 51:973-83. 2012
  4. pmc Impact of race and ethnicity on features and outcome of ductal carcinoma in situ of the breast
    Adele A Bailes
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Cancer 119:150-7. 2013
  5. pmc Perception of generic prescription drugs and utilization of generic drug discount programs
    Anthony Omojasola
    Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Ethn Dis 22:479-85. 2012
  6. pmc Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis
    Celia Garcia-Prieto
    Department of Translational Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 288:3240-50. 2013
  7. pmc Associations between body size and serum estradiol and sex hormone-binding globulin levels in premenopausal African American women
    Raheem J Paxton
    The Dorothy I Height Center for Health Equity and Evaluation Research CHEER, University of Houston and The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1440, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 98:E485-90. 2013
  8. ncbi Cytokinesis-blocked micronucleus cytome assay and spectral karyotyping as methods for identifying chromosome damage in a lung cancer case-control population
    Stacy M Lloyd
    Dorothy I Height Center for Health Equity and Evaluation Research, Division of Cancer Prevention and Population Science, The UT MD Anderson Cancer Center, Houston, TX, USA
    Genes Chromosomes Cancer 52:694-707. 2013
  9. pmc Prenatal exposure to phthalates is associated with decreased anogenital distance and penile size in male newborns
    L P Bustamante-Montes
    1 Unidad de Investigación con Enfoque Ecosistémico, Facultad de Medicina, Universidad Autonoma del Estado de Mexico, Paseo Tollocan esq Jesús Carranza, Toluca, C P 50180, Edo de Mexico, Mexico
    J Dev Orig Health Dis 4:300-6. 2013
  10. pmc The influence of discrimination on smoking cessation among Latinos
    Darla E Kendzor
    The University of Texas Health Science Center, School of Public Health, United States The UT Southwestern Harold C Simmons Comprehensive Cancer Center, United States Electronic address
    Drug Alcohol Depend 136:143-8. 2014

Scientific Experts

  • Denae King
  • Beverly Jean Gor
  • Shedra Amy Snipes
  • Angelica P Herrera
  • Patricia Y Miranda
  • Raheem J Paxton
  • Mariá A Hernández-Valero
  • Lovell A Jones
  • Beverly J Gor
  • Richard A Hajek
  • M A Hernández-Valero
  • Mike Hernandez
  • Darla E Kendzor
  • Stacy M Lloyd
  • L P Bustamante-Montes
  • Adele A Bailes
  • Celia Garcia-Prieto
  • Anthony Omojasola
  • Jie Tian
  • Melissa L Bondy
  • Anna V Wilkinson
  • María del Rosario Rodríguez-Guillén
  • Janice A Chilton
  • Cayla R Teal
  • L Du Xianglin
  • María R Schettino
  • R A Hajek
  • Janice Allen Chilton
  • Michael S Businelle
  • Claire E Adams
  • Jennifer I Vidrine
  • Paul M Cinciripini
  • Cho Y Lam
  • David W Wetter
  • Carlos A Mazas
  • Yessenia Castro
  • Virmarie Correa-Fernández
  • Lorraine R Reitzel
  • Miguel Ángel Cano
  • Changgang Lou
  • I Gorlov
  • A Amaya-Chávez
  • V H Borja-Aburto
  • Abenaa M Brewster
  • Peng Huang
  • J Rother
  • M García-Fabila
  • D Flores-Pimentel
  • M Frazier
  • Yan Zhou
  • Zhendong Jin
  • Zhao Chen
  • Henry M Kuerer
  • Kausar Begam Riaz Ahmed
  • Randa El-Zein
  • Mirtha Lopez
  • Ying Kang
  • Yan Mei
  • O Gorlova
  • Naima Hammoudi
  • Sara A Lari
  • D B Barr
  • Isabel Lambertz
  • Thomas R Berton
  • Norma Olvera
  • Robin Fuchs-Young
  • L Patricia Bustamante-Montes
  • Susan M Fischer
  • Sujit Sansgiry
  • Kaoru Kiguchi
  • Stephanie H Shirley
  • Lovell Jones
  • John DiGiovanni
  • Joyce E Rundhaug
  • Claudio J Conti
  • Elizabeth Halley-Castillo
  • Pamela T Camingue
  • Marcia Galván-Portillo
  • Jia Chen
  • Irma Silva-Zolezzi
  • Lizbeth Lopez-Carrillo
  • Luisa Torres-Sanchez
  • Julia Blanco-Munoz
  • Miriam Aracely Anaya
  • Cynthia A Thomson
  • Andrea J Shelton
  • Angelina Esparza
  • Shirley W Flatt
  • Truongson V Hoang
  • John P Pierce

Detail Information

Publications30

  1. ncbi Detection of chromosomal aberrations by fluorescence in situ hybridization in cervicovaginal biopsies from women exposed to diethylstilbestrol in utero
    R A Hajek
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Gynecol Cancer 16:318-24. 2006
    ..These data suggest that DES-induced chromosomal trisomy may be an early event in the development of cervicovaginal neoplasia in humans...
  2. ncbi Higher risk for obesity among Mexican-American and Mexican immigrant children and adolescents than among peers in Mexico
    Mariá A Hernández-Valero
    Center for Research on Minority Health, Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA
    J Immigr Minor Health 14:517-22. 2012
    ..In addition, future obesity research should take into consideration the country of origin of the study population to develop more culturally specific obesity interventions...
  3. pmc Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands
    Jie Tian
    Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, Texas 78957, USA
    Mol Carcinog 51:973-83. 2012
    ..2011 Wiley Periodicals, Inc...
  4. pmc Impact of race and ethnicity on features and outcome of ductal carcinoma in situ of the breast
    Adele A Bailes
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Cancer 119:150-7. 2013
    ..The impact of race and ethnicity on the biologic features and outcome variables of women who are diagnosed with preinvasive breast cancer-ductal carcinoma in situ (DCIS)-has not been addressed widely in the published literature...
  5. pmc Perception of generic prescription drugs and utilization of generic drug discount programs
    Anthony Omojasola
    Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Ethn Dis 22:479-85. 2012
    ..Our study aimed to assess patient's perceptions of generic drugs and utilization of generic drug discount programs...
  6. pmc Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis
    Celia Garcia-Prieto
    Department of Translational Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 288:3240-50. 2013
    ..The extremely potent activity of OSW-1 against leukemia cells and its unique mechanism of action suggest that this compound may be potentially useful in the treatment of leukemia...
  7. pmc Associations between body size and serum estradiol and sex hormone-binding globulin levels in premenopausal African American women
    Raheem J Paxton
    The Dorothy I Height Center for Health Equity and Evaluation Research CHEER, University of Houston and The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1440, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 98:E485-90. 2013
    ..African American (AA) women have the highest rates of premenopausal breast cancer; however, it is unclear whether body size contributes to the hormonal patterns potentially associated with increased breast cancer risk in these women...
  8. ncbi Cytokinesis-blocked micronucleus cytome assay and spectral karyotyping as methods for identifying chromosome damage in a lung cancer case-control population
    Stacy M Lloyd
    Dorothy I Height Center for Health Equity and Evaluation Research, Division of Cancer Prevention and Population Science, The UT MD Anderson Cancer Center, Houston, TX, USA
    Genes Chromosomes Cancer 52:694-707. 2013
    ....
  9. pmc Prenatal exposure to phthalates is associated with decreased anogenital distance and penile size in male newborns
    L P Bustamante-Montes
    1 Unidad de Investigación con Enfoque Ecosistémico, Facultad de Medicina, Universidad Autonoma del Estado de Mexico, Paseo Tollocan esq Jesús Carranza, Toluca, C P 50180, Edo de Mexico, Mexico
    J Dev Orig Health Dis 4:300-6. 2013
    ..2604, P = 0.050). Human exposure to phthalates is a public health concern, and the system most vulnerable to its potential effects seems to be the immature male reproductive tract. ..
  10. pmc The influence of discrimination on smoking cessation among Latinos
    Darla E Kendzor
    The University of Texas Health Science Center, School of Public Health, United States The UT Southwestern Harold C Simmons Comprehensive Cancer Center, United States Electronic address
    Drug Alcohol Depend 136:143-8. 2014
    ..Thus, the purpose of the current study was to determine the influence of everyday and major discrimination on smoking cessation among Latinos making a quit attempt...
  11. pmc Interplay between polymorphisms and methylation in the H19/IGF2 gene region may contribute to obesity in Mexican-American children
    M A Hernández-Valero
    1 Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Dev Orig Health Dis 4:499-506. 2013
    ..04). Our results suggest that CpG4 methylation status may be associated with childhood obesity in Mexican-American children in a sex-specific manner. ..
  12. pmc Comparison of baseline dietary intake of Hispanic and matched non-Hispanic white breast cancer survivors enrolled in the Women's Healthy Eating and Living study
    Mariá A Hernández-Valero
    Center for Research on Minority Health, Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Diet Assoc 108:1323-9. 2008
    ..To assess the reported baseline dietary intake of Hispanic and non-Hispanic white breast cancer survivors in the Women's Healthy Eating and Living study, a randomized plant-based dietary intervention clinical trial...
  13. ncbi Development of a health risk factors questionnaire for Chinese and Vietnamese residents of the Houston, Texas area
    Beverly J Gor
    Department of Health Disparities Research, Center for Research on Minority Health, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 639, Houston, TX 77030, USA
    J Immigr Minor Health 10:373-7. 2008
    ..This report describes the steps used in adapting, modifying and developing the survey instrument, and provides insights, which may assist other investigators conducting similar research...
  14. ncbi Maternal BMI and country of birth as indicators of childhood obesity in children of Mexican origin
    Mariá A Hernández-Valero
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Obesity (Silver Spring) 15:2512-9. 2007
    ....
  15. ncbi Is the MEDFICTS rapid dietary fat screener valid for premenopausal African-American women?
    Cayla R Teal
    Houston Center for Quality of Care and Utilization Studies, Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Diet Assoc 107:773-81. 2007
    ....
  16. pmc Racial disparities and trends in radiation therapy after breast-conserving surgery for early-stage breast cancer in women, 1992 to 2002
    L Du Xianglin
    School of Public Health, Division of Epidemiology, University of Texas Health Science Center, Houston 77030, USA
    Ethn Dis 17:122-8. 2007
    ..We do not know whether racial/ethnic disparities in this therapy exist and how disparities may have changed over time...
  17. ncbi Bioethics and health disparity: Adding diversity to the debate
    Janice Allen Chilton
    Department of Health Disparities Research, Center for Research on Minority Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Cancer Educ 21:S101-4. 2006
    ..Ethicists are needed from diverse populations who can enhance moral debate by offering cultural insight as choices are made as to how society should approach the expanding medical and biological possibilities...
  18. ncbi Assessing breast cancer knowledge, beliefs, and misconceptions among Latinas in Houston, Texas
    María R Schettino
    Center for Research on Minority Health, Department of Health Disparities Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Cancer Educ 21:S42-6. 2006
    ..Limited breast cancer knowledge and beliefs, risk factors, screening procedures, and cultural barriers may keep Latinas from seeking health care...
  19. ncbi Between and within: international perspectives on cancer and health disparities
    Lovell A Jones
    Center for Research on Minority Health, The University of Texas M D Anderson Cancer Cen, Houston, TX 77030, USA
    J Clin Oncol 24:2204-8. 2006
    ..To address these problems, it will be necessary to focus attention on what can be done locally-within countries, not only between countries...
  20. pmc A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors
    Raheem J Paxton
    Dorothy I Height Center for Health Equity and Evaluation Research, University of Houston and University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Gynecol Oncol 124:410-6. 2012
    ..Few studies have examined the dietary habits of ovarian cancer survivors. Therefore, we conducted a study to assess the feasibility and impact of two dietary interventions for ovarian cancer survivors...
  21. pmc Maternal MTHFR polymorphisms and risk of spontaneous abortion
    María del Rosario Rodríguez-Guillén
    National Institute of Public Health, Morelos, Mexico
    Salud Publica Mex 51:19-25. 2009
    ..To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C)...
  22. pmc Health and healthcare perspectives of African American residents of an unincorporated community: a qualitative assessment
    Denae W King
    Department of Health Disparities Research, Center for Research on Minority Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 639, Houston, TX 77071, USA
    Health Place 15:420-8. 2009
    ..Our findings suggest a need to begin to examine health outcomes for minority residents in other unincorporated communities...
  23. pmc Policy implications of early onset breast cancer among Mexican-origin women
    Patricia Y Miranda
    Department of Health Disparities Research, The University of Texas M D Anderson Cancer Center, PO Box 301402 Unit 639, Houston, TX 77230 1402, USA
    Cancer 117:390-7. 2011
    ..An additional 3700 lives could be saved if 90% of women aged ≥40 years were recently screened for breast cancer...
  24. ncbi Young Asian Americans' knowledge and perceptions of cervical cancer and the human papillomavirus
    Beverly J Gor
    Department of Health Disparities Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immigr Minor Health 13:81-6. 2011
    ..Culturally relevant education materials that consider specific Asian ethnicity and language are needed to increase awareness of cervical cancer, Pap testing, and HPV among Asian American young adults...
  25. pmc Strategies for Recruitment of Healthy Premenopausal Women into the African American Nutrition for Life (A NULIFE) Study
    Denae W King
    The University of Texas, MD Anderson Cancer Center, Center for Research on Minority Health, Houston, Texas 77230, USA
    J Womens Health (Larchmt) 19:855-62. 2010
    ..However, the strategies needed to recruit younger African American women have not been well defined...
  26. pmc Addressing cancer health disparities using a global biopsychosocial approach
    Denae King
    Department of Health Disparities Research, Center for Research on Minority Health, PO Box 301402, Unit 639, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Cancer 116:264-9. 2010
    ..Examples and recommendations for implementation of the biopsychosocial approach as it applies to cancer health disparities research are described...
  27. pmc "Pesticides protect the fruit, but not the people": using community-based ethnography to understand farmworker pesticide-exposure risks
    Shedra Amy Snipes
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Public Health 99:S616-21. 2009
    ..We used community-based ethnography and public health risk assessment to assess beliefs about pesticide exposure risks among farmworkers in the Lower Yakima Valley of Washington State...
  28. pmc Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change
    Angelica P Herrera
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Am J Public Health 100:S105-12. 2010
    ....