Micronutrients, stroke and cognition in aging

Summary

Principal Investigator: I H Rosenberg
Abstract: A major determinant of the quality of life for elderly individuals is the efficiency of their mental processes. Loss of neurocognitive functioning has been noted in elderly individuals; the severity of this loss ranges from simple memory deficits to profound dementia of the Alzheimer's variety. It is important to discover to what extent such functional decline is preventable and reversible. Specific to this project is the possibility that nutritional factors are important. Since estimates of the incidence of micronutrient deficiency in the elderly is quite large, intervention could significantly reduce the public health burden. The aim of this multidisciplinary study is to determine the prevalence of elevated homocysteine, brain disease, and cognitive decline in the homebound elderly. From 7500 homebound elderly, representative of all registered cases from a specified geographical area, a cohort of 1600 elders will be assessed. The assessment will include dietary history and serum nutrient levels, as well as comprehensive neuropsychological testing. Clinical examination and MRI scans will be performed on a subset of 400 subjects. Known risks for cognitive impairment such as diagnosed depression, anxiety, hypertension, diabetes, atrial fibrillation, medications, APOE, saturated fat intake, and mutations of MTHFR will be measured and included in analyses as covariates and effect modifiers.
Funding Period: 2002-06-15 - 2008-05-31
more information: NIH RePORT

Top Publications

  1. ncbi High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 82:627-35. 2005
  2. ncbi Association between linear measurements of corpus callosum and gait in the elderly
    Harald Brodoefel
    Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Eur Radiol 23:2252-7. 2013
  3. ncbi Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study
    Xiang Feng
    Departmennt of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, China
    Asia Pac J Clin Nutr 22:150-9. 2013
  4. pmc Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults
    Denish Moorthy
    Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 142:1554-60. 2012
  5. pmc Diffusion tensor imaging, white matter lesions, the corpus callosum, and gait in the elderly
    Refeeque A Bhadelia
    Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Stroke 40:3816-20. 2009
  6. pmc MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1377-86. 2010
  7. pmc Depression and glycemic intake in the homebound elderly
    D Mkaya Mwamburi
    Department of Public Health and Family Medicine, Tufts University, United States
    J Affect Disord 132:94-8. 2011
  8. ncbi The relationship between plasma amyloid-β peptides and the medial temporal lobe in the homebound elderly
    Xiaoyan Sun
    Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, MA, USA
    Int J Geriatr Psychiatry 26:593-601. 2011
  9. ncbi Clinical prediction of fall risk and white matter abnormalities: a diffusion tensor imaging study
    Bang Bon Koo
    Departments of Anatomy and Neurobiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Arch Neurol 69:733-8. 2012
  10. pmc 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services
    J S Buell
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Neurology 74:18-26. 2010

Scientific Experts

  • Chao Qiang Lai
  • Refeeque A Bhadelia
  • Sami H Erbay
  • Tammy Maria Scott
  • D E Weiner
  • Wei Qiao Qiu
  • Katherine Tucker
  • Marshal Folstein
  • Xiaoyan Sun
  • D Mkaya Mwamburi
  • Irwin Rosenberg
  • Jennifer S Buell
  • Peter Bergethon
  • Elizabeth Liebson
  • Harald Brodoefel
  • Xiang Feng
  • Laurence D Parnell
  • Jose M Ordovas
  • Bang Bon Koo
  • Denish Moorthy
  • Inga Peter
  • Irwin H Rosenberg
  • J S Buell
  • Kathleen Bungay
  • Lisa N Arsenault
  • Bess Dawson-Hughes
  • Jacqueline Yee
  • Paul Summergrad
  • Marius Horger
  • Gustavo Pantol
  • Ramesh Ramachandran
  • Wen Hua Ling
  • Rafael Rojas
  • Jian Shen
  • Yu Chi Lee
  • Jimmy W Crott
  • Louis R Caplan
  • John Griffith
  • Jacob Selhub
  • Mohammed Hussain
  • Aron M Troen
  • Jay Jiguang Zhu
  • Samuel Patz
  • G E Dallal
  • W Q Qui
  • P Bergethon
  • I H Rosenberg
  • B Dawson-Hughes
  • S Patz
  • Joshua Claunch
  • Natalia A Crivello
  • Alice H Lichtenstein
  • Lixia Wang
  • Gerard Dallal
  • Gerard E Dallal
  • Nirupa Matthan
  • Chi Chia Chiu
  • David C Steffens
  • Rhoda Au
  • Jasmin Prasad
  • Yu Min Lin
  • Timothy C Liu

Detail Information

Publications23

  1. ncbi High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 82:627-35. 2005
    ..It is not clear whether the observed associations between homocysteine and cognitive measures are causal or whether they are due to homocysteine, to independent actions of the B vitamins, or to both...
  2. ncbi Association between linear measurements of corpus callosum and gait in the elderly
    Harald Brodoefel
    Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Eur Radiol 23:2252-7. 2013
    ..However, such measurements are impracticable in clinical routine. The purpose of this study was to evaluate the association between simple linear measurements of CC thickness with gait...
  3. ncbi Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study
    Xiang Feng
    Departmennt of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, China
    Asia Pac J Clin Nutr 22:150-9. 2013
    ..We examined the relationship between common variants in IRS1, type 2 diabetes, and related traits including insulin resistance, hyperglycemia and DNA damage in the Boston Puerto Rican Health Study...
  4. pmc Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults
    Denish Moorthy
    Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 142:1554-60. 2012
    ..The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression...
  5. pmc Diffusion tensor imaging, white matter lesions, the corpus callosum, and gait in the elderly
    Refeeque A Bhadelia
    Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Stroke 40:3816-20. 2009
    ..Our purpose was to investigate the relationship between the integrity of white matter in the corpus callosum as determined by DTI and quantitative measures of gait in the elderly...
  6. pmc MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1377-86. 2010
    ..The S-adenosylmethionine synthetase type 1 (MAT1A) gene encodes a key enzyme in one-carbon nutrient metabolism...
  7. pmc Depression and glycemic intake in the homebound elderly
    D Mkaya Mwamburi
    Department of Public Health and Family Medicine, Tufts University, United States
    J Affect Disord 132:94-8. 2011
    ..We aimed to study the relationship between depression and glycemic intake in the elderly, and examine whether antidepressant use modified this relationship...
  8. ncbi The relationship between plasma amyloid-β peptides and the medial temporal lobe in the homebound elderly
    Xiaoyan Sun
    Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, MA, USA
    Int J Geriatr Psychiatry 26:593-601. 2011
    ..We thus examined the relationship between plasma Aβ levels and brain volumes...
  9. ncbi Clinical prediction of fall risk and white matter abnormalities: a diffusion tensor imaging study
    Bang Bon Koo
    Departments of Anatomy and Neurobiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Arch Neurol 69:733-8. 2012
    ..The Tinetti scale is a simple clinical tool designed to predict risk of falling by focusing on gait and stance impairment in elderly persons. Gait impairment is also associated with white matter (WM) abnormalities...
  10. pmc 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services
    J S Buell
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Neurology 74:18-26. 2010
    ..However, no studies have examined the association between vitamin D status, dementia, and cranial MRI indicators of cerebrovascular disease (CVD)...
  11. pmc Depression and plasma amyloid beta peptides in the elderly with and without the apolipoprotein E4 allele
    Xiaoyan Sun
    Department of Psychiatry, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
    Alzheimer Dis Assoc Disord 23:238-44. 2009
    ....
  12. pmc Validity of estimated dietary eicosapentaenoic acid and docosahexaenoic acid intakes determined by interviewer-administered food frequency questionnaire among older adults with mild-to-moderate cognitive impairment or dementia
    Lisa N Arsenault
    Tufts University, Boston, Massachusetts 02124, USA
    Am J Epidemiol 170:95-103. 2009
    ..This frequency was consistently high across all cognitive categories. With interviewer administration, this FFQ seems to be a valid method of assessing dietary EPA + DHA intake in older adults with mild-to-moderate cognitive impairment...
  13. pmc Vitamin D is associated with cognitive function in elders receiving home health services
    Jennifer S Buell
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 64:888-95. 2009
    ..The objective of this study was to examine the association between 25-hydroxyvitamin D, 25(OH)D, and cognitive function...
  14. pmc Albuminuria, cognitive functioning, and white matter hyperintensities in homebound elders
    Daniel E Weiner
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 53:438-47. 2009
    ..Albuminuria, a kidney marker of microvascular disease, may herald microvascular disease elsewhere, including in the brain...
  15. ncbi Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis
    Wei Qiao Qiu
    Department of Psychiatry, New England Medical Center and Tufts University School of Medicine, 150 Harrison Avenue, Rm 234, Boston, MA 02111, USA
    Neurobiol Aging 27:190-8. 2006
    ..Further studies of the role of IDE in the pathogenesis of AD, which may uncover potential treatment target, are much needed...
  16. ncbi Nerve atrophy in severe trigeminal neuralgia: noninvasive confirmation at MR imaging--initial experience
    Sami H Erbay
    Department of Radiology, Tufts New England Medical Center, 750 Washington St, Boston, MA 02467, USA
    Radiology 238:689-92. 2006
    ..To retrospectively evaluate the size of the trigeminal nerve on magnetic resonance (MR) images of patients with unilateral trigeminal neuralgia...
  17. ncbi Executive dysfunction in homebound older people with diabetes mellitus
    Wei Qiao Qiu
    Friedman School of Nutrition Science and Policy, Department of Psychiatry, Clinical Research Center, Tufts University, Boston, Massachusetts 02111, USA
    J Am Geriatr Soc 54:496-501. 2006
    ..To describe patterns of cognitive deficits and activities of daily living (ADLs) in older people with diabetes mellitus...
  18. ncbi The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population
    Tammy M Scott
    Tufts New England Medical Center, Boston, MA 02111, USA
    Int J Geriatr Psychiatry 21:519-28. 2006
    ..Understanding mediating factors by which micronutrient status affects cognitive function would contribute to elders' quality of life and their ability to remain in the home...
  19. ncbi Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly
    Wei Qiao Qiu
    Department of Psychiatry, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Int J Geriatr Psychiatry 22:536-42. 2007
    ..Plasma Amyloid-beta peptide 42 (Abeta42) declines before and soon after the onset of AD, yet the relationship between plasma Abeta42 and depression is unclear...
  20. ncbi The homocysteine hypothesis of depression
    Marshal Folstein
    Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
    Am J Psychiatry 164:861-7. 2007
    ..Longitudinal studies and clinical trials should be designed to challenge the hypothesis...
  21. ncbi Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular disease
    Xiaoyan Sun
    Department of Psychiatry, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Biol Psychiatry 62:1413-7. 2007
    ..Low plasma amyloid-beta peptide 42 (Abeta42) is associated with depressive symptoms independently of cardiovascular disease (CVD) in the elderly. It is critical to investigate whether antidepressants modify this relationship...
  22. pmc Amyloid-associated depression: a prodromal depression of Alzheimer disease?
    Xiaoyan Sun
    Department of Psychiatry, Tufts New England Medical Center, Campus Box 1007, 750 Washington St, Boston, MA 02111, USA
    Arch Gen Psychiatry 65:542-50. 2008
    ..In a previous study, we reported that depression is also associated with low plasma Abeta(42) levels in the elderly population...
  23. pmc Vitamin D and neurocognitive dysfunction: preventing "D"ecline?
    Jennifer S Buell
    Friedman School of Nutrition Science and Policy at Tufts University, USA
    Mol Aspects Med 29:415-22. 2008
    ..These findings potentially implicate vitamin D in neurocognitive function...