A CHEMICALLY SYNTHETIC ANTI-TOXIC VACCINE AGAINST MALARI

Summary

Principal Investigator: L Schofield
Abstract: DESCRIPTION (Adapted from the Applicant's Abstract): Plasmodium falciparum is a global health problem because of the morbidity and mortality associated with infection. Much of this morbidity and mortality is believed to arise from the actions of a malaria toxin. The toxin initiates a systemic inflammatory cascade involving cytokine excess, which may result in disseminated intravascular coagulation, hepatic dysfunction, acute renal failure, multi-organ inflammation, hypoglycemia, lactic acidosis and death. The toxin may further contribute to organ-specific and cerebral disease syndromes by hyperactivation of the vascular endothelium. Clinical immunity to malaria is acquired considerably earlier than anti-parasite immunity, and it is possible that this is mediated by anti-toxin mechanisms.
Funding Period: 2000-09-15 - 2003-08-31
more information: NIH RePORT

Top Publications

  1. ncbi gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria
    Diana S Hansen
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Eur J Immunol 37:1864-73. 2007
  2. ncbi The role of leukocytes bearing Natural Killer Complex receptors and Killer Immunoglobulin-like Receptors in the immunology of malaria
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville 3050, Victoria, Australia
    Curr Opin Immunol 19:416-23. 2007

Detail Information

Publications2

  1. ncbi gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria
    Diana S Hansen
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Eur J Immunol 37:1864-73. 2007
    ..Applied to longitudinal cohort studies in endemic regions, similar comparative phenotyping should allow assessment of the contribution of diverse cell populations and regulatory receptors to risk of infection and disease...
  2. ncbi The role of leukocytes bearing Natural Killer Complex receptors and Killer Immunoglobulin-like Receptors in the immunology of malaria
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville 3050, Victoria, Australia
    Curr Opin Immunol 19:416-23. 2007
    ..Population-based immunogenetic analyses should allow the identification of NKC and KIR loci controlling innate and adaptive immune responses to malaria and associated with altered risk of infection and disease...