Prospective studies of cancer etiology and prevention in Shanghai and Singapore

Summary

Principal Investigator: Jian Min Yuan
Abstract: DESCRIPTION (provided by applicant): This proposal seeks funding to continue the observational follow-up of the 81,501 middle-aged and older Chinese men and women participants of the Shanghai and Singapore cohort studies for another 5 five years, to accrue and validate a substantially increased number of cancer endpoints in order to evaluate important questions related to lifestyle, biochemical markers, genetic markers, and gene-environment interactions on cancer risk. The Shanghai cohort was assembled in 1986-1989 and the Singapore cohort in 1993-1998. In addition to data collected at baseline and follow-up interviews, blood and urine samples were collected from more than 50,000 subjects at baseline and stored in ultra-low temperature condition since their collection. The vigorous and effective follow-up procedures kept the loss of follow-up to be minimal;to date, only approximately 880 (1%) original cohort participants have been lost to follow-up over the past 20 years. These databases have been serving unique resources for a large number of projects for research on cancer etiology and prevention. In the next 5 five years, we also propose to conduct a series of nested case-control studies within the two cohorts to elucidate the role of environmental exposure, genetic variants and DNA methylation in the development of lung or liver cancer. The primary scientific aims are: (1) to assess the independent role of polycyclic aromatic hydrocarbons (PAH), 1,3-butadiene, acrolein, benzene, and ethylene oxide in the development of lung cancer among smokers;(2) to assess independent role of PAH, 1,3-butadiene, acrolein, benzene, and ethylene oxide in the development of lung cancer among lifelong nonsmokers;(3) to assess the role of methyl groups - S-adenosylmethionine, S-adenosylhomocysteine, methionine, choline, homocysteine, folate, vitamins B6 and B12 in the development of liver cancer;(4) to assess the role of genetic polymorphisms influencing methyl group metabolism in the development of liver cancer, and their modifying effect on the associations between methyl groups and liver cancer risk;and (5) to assess the role of global DNA hypomethylation in the development of liver cancer. The proposed studies with prospective study design, available pre-diagnostic blood and urine samples, and large sample sizes will provide novel and definitive data to accomplish these scientific aims. Furthermore, findings of the proposed studies will provide insights for the understanding of the role of methyl groups, the donor of DNA methylation, in human hepatocarcinogenesis. The ultimate goal of the proposed research is the development of an effective set of non-invasive, predictive markers that allow for the identification of the relatively small fraction of individuals who are at very high risk for lung or liver cancer. People with high risk could take primary preventive measures to reduce their risk, or undergo regular screening for early detection of the malignancies when clinical treatment is more effective. PUBLIC HEALTH RELEVANCE: The Shanghai and Singapore cohort studies are ongoing observational follow-up investigation of environmental and genetic factors on human cancers in 81,501 middle-aged and older Chinese men and women beginning in 1986 and 1993, respectively. The proposed studies within these two cohorts will identify a set of non-invasive, predictive markers of lung and liver cancer development. People with high risk could take primary preventive measures to reduce their risk, or undergo regular screening for early detection of the malignancies when clinical treatment is more effective. The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans.
Funding Period: 2010-01-15 - 2014-12-31
more information: NIH RePORT

Top Publications

  1. pmc Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the Shanghai Cohort Study
    Jian Min Yuan
    Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Carcinogenesis 35:339-45. 2014
  2. pmc Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites
    Irina Stepanov
    Division of Environmental Health Sciences, University of Minnesota, Minneapolis, MN Masonic Cancer Center, University of Minnesota, Minneapolis, MN
    Int J Cancer 134:2278-83. 2014
  3. pmc Mitochondrial DNA copy number is associated with breast cancer risk
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 8:e65968. 2013
  4. ncbi Smoking cessation and mortality among middle-aged and elderly Chinese in Singapore: the Singapore Chinese Health Study
    Sin How Lim
    Saw Swee Hock School of Public Health, National University of Singapore, 16 Medical Drive, Singapore, Singapore
    Tob Control 22:235-40. 2013
  5. pmc Protective effects of dietary carotenoids on risk of hip fracture in men: the Singapore Chinese Health Study
    Zhaoli Dai
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    J Bone Miner Res 29:408-17. 2014
  6. ncbi Dietary fiber intake modifies the association between secondhand smoke exposure and coronary heart disease mortality among Chinese non-smokers in Singapore
    Maggie L Clark
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA Electronic address
    Nutrition 29:1304-9. 2013
  7. pmc Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma
    Lesley M Butler
    Authors Affiliations Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute and Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California and Department of Epidemiology, Shanghai Cancer Institute, Shanghai, PR China
    Cancer Epidemiol Biomarkers Prev 22:1884-93. 2013
  8. pmc Smoking and risk of kidney failure in the Singapore Chinese health study
    Aizhen Jin
    National Registry of Diseases Office, Health Promotion Board, Singapore, Singapore
    PLoS ONE 8:e62962. 2013
  9. pmc Higher parity is associated with an increased risk of type-II diabetes in Chinese women: the Singapore Chinese Health Study
    N T Mueller
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
    BJOG 120:1483-9. 2013
  10. pmc Serum urate levels and consumption of common beverages and alcohol among Chinese in Singapore
    Gim Gee Teng
    University Medicine Cluster, National University Health System, and Yong Loo School of Medicine, National University of Singapore, Singapore, Singapore
    Arthritis Care Res (Hoboken) 65:1432-40. 2013

Detail Information

Publications74

  1. pmc Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the Shanghai Cohort Study
    Jian Min Yuan
    Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Carcinogenesis 35:339-45. 2014
    ..This study demonstrates a potentially important role of exposure to PAH in the development of lung cancer among lifelong never smokers. ..
  2. pmc Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites
    Irina Stepanov
    Division of Environmental Health Sciences, University of Minnesota, Minneapolis, MN Masonic Cancer Center, University of Minnesota, Minneapolis, MN
    Int J Cancer 134:2278-83. 2014
    ....
  3. pmc Mitochondrial DNA copy number is associated with breast cancer risk
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 8:e65968. 2013
    ..Future studies are warranted to confirm these findings and to elucidate the biological role of mtDNA copy number in breast cancer risk...
  4. ncbi Smoking cessation and mortality among middle-aged and elderly Chinese in Singapore: the Singapore Chinese Health Study
    Sin How Lim
    Saw Swee Hock School of Public Health, National University of Singapore, 16 Medical Drive, Singapore, Singapore
    Tob Control 22:235-40. 2013
    ..This study determines if recent smoking cessation, compared with long-term cessation, can reduce mortality risk associated with smoking...
  5. pmc Protective effects of dietary carotenoids on risk of hip fracture in men: the Singapore Chinese Health Study
    Zhaoli Dai
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    J Bone Miner Res 29:408-17. 2014
    ..This study suggests that adequate intake of vegetables may reduce risk of osteoporotic fractures among elderly men and that the antioxidant effects of carotenoids may counteract the mechanism of osteoporosis related to leanness...
  6. ncbi Dietary fiber intake modifies the association between secondhand smoke exposure and coronary heart disease mortality among Chinese non-smokers in Singapore
    Maggie L Clark
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA Electronic address
    Nutrition 29:1304-9. 2013
    ..The aim of this study was to evaluate the hypothesized modifying role of nutrients with known antioxidant and/or anti-inflammatory properties on the relationship between SHS exposure and CHD mortality...
  7. pmc Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma
    Lesley M Butler
    Authors Affiliations Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute and Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California and Department of Epidemiology, Shanghai Cancer Institute, Shanghai, PR China
    Cancer Epidemiol Biomarkers Prev 22:1884-93. 2013
    ..Prospective studies in humans on circulating choline and other one-carbon metabolites and hepatocellular carcinoma risk have been lacking...
  8. pmc Smoking and risk of kidney failure in the Singapore Chinese health study
    Aizhen Jin
    National Registry of Diseases Office, Health Promotion Board, Singapore, Singapore
    PLoS ONE 8:e62962. 2013
    ..The relationship between smoking and risk of kidney failure, especially in people of Chinese origin, is not clear. We analyzed data from the Singapore Chinese Health Study to investigate whether smoking increases the risk of kidney failure...
  9. pmc Higher parity is associated with an increased risk of type-II diabetes in Chinese women: the Singapore Chinese Health Study
    N T Mueller
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
    BJOG 120:1483-9. 2013
    ..Here, we examine whether parity was positively associated with incident type-II diabetes in Singaporean Chinese women...
  10. pmc Serum urate levels and consumption of common beverages and alcohol among Chinese in Singapore
    Gim Gee Teng
    University Medicine Cluster, National University Health System, and Yong Loo School of Medicine, National University of Singapore, Singapore, Singapore
    Arthritis Care Res (Hoboken) 65:1432-40. 2013
    ..Western studies suggest that beverages may affect serum urate (SU) levels, but data from Asian populations are scarce. We evaluated the associations between beverages and SU levels in Singaporean Chinese...
  11. pmc Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study
    Li Tao
    Cancer Prevention Institute of California, Fremont, CA, USA
    Cancer Epidemiol Biomarkers Prev 22:937-45. 2013
    ..Other arylamine compounds, including 2,6-dimethylaniline (2,6-DMA), have been implicated as possible human bladder carcinogens. Hemoglobin adducts of 4-ABP and 2,6-DMA are validated biomarkers of exposure to those compounds in humans...
  12. pmc Hormone metabolism genes and mammographic density in Singapore Chinese women
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cancer Epidemiol Biomarkers Prev 22:984-6. 2013
    ..We investigated the association between genetic variation in the hormone metabolism and signaling pathway and mammographic density, a strong predictor of breast cancer risk...
  13. pmc Combined lifestyle factors and risk of incident colorectal cancer in a Chinese population
    Andrew O Odegaard
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA
    Cancer Prev Res (Phila) 6:360-7. 2013
    ..Conversely, there was no association with rectal cancer risk. An increasing protective lifestyle factor index score is associated with a marked decreased risk of developing colon cancer in Chinese men and women...
  14. pmc Asthma and the risk of type 2 diabetes in the Singapore Chinese Health Study
    Noel T Mueller
    University of Minnesota School of Public Health, Division of Epidemiology and Community Health, 1300 S 2nd St, Suite 300, Minneapolis MN 55454, United States
    Diabetes Res Clin Pract 99:192-9. 2013
    ..In the present study, we investigated the hypothesis that asthma is associated with an increased risk of incident type 2 diabetes in Chinese adults...
  15. pmc Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Res 73:1876-82. 2013
    ..Our data support that TGFB1 genetic variation may be an important genetic determinant of mammographic density measure that predicts breast cancer risk, particularly in nulliparous women...
  16. pmc Genetic polymorphisms of epidermal growth factor in relation to risk of hepatocellular carcinoma: two case-control studies
    Jian Min Yuan
    Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, Suite 4C, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    BMC Gastroenterol 13:32. 2013
    ..A polymorphism in the EGF gene (61A > G) results in elevation of EGF in liver tissues and blood. Epidemiological data are sparse on the possible association between EGF genetic polymorphism and HCC risk...
  17. pmc Calcium intake is not related to breast cancer risk among Singapore Chinese women
    Jingmei Li
    Human Genetics, Genome Institute of Singapore, Singapore, Singapore
    Int J Cancer 133:680-6. 2013
    ..Our findings do not support a hypothesis for calcium in breast cancer chemoprevention, contrary to findings from previous studies among Western populations with higher calcium intake primarily from dairy products and supplements...
  18. ncbi All-cause and cause-specific mortality after hip fracture among Chinese women and men: the Singapore Chinese Health Study
    G C H Koh
    Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Block MD3, 03 20, 16 Medical Drive, 117597 Singapore, Singapore
    Osteoporos Int 24:1981-9. 2013
    ..All-cause mortality risk persisted for 5 years after hip fractures in both men and women. There may be gender-specific differences in effect and duration of excess risk for cause-specific mortality after hip fracture...
  19. ncbi Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study
    Z Dai
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    Osteoporos Int 24:2049-59. 2013
    ..These findings suggest that maintaining sufficient pyridoxine intake may be beneficial in preserving bone health in postmenopausal women...
  20. pmc Fried meat intake is a risk factor for lung adenocarcinoma in a prospective cohort of Chinese men and women in Singapore
    Lesley M Butler
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Carcinogenesis 34:1794-9. 2013
    ..Our prospective results for fried meat intake support consumption as an important route of exposure to compounds from Chinese-style high-temperature cooking for the development of lung adenocarcinoma. ..
  21. pmc Coffee intake and gastric cancer risk: the Singapore Chinese health study
    Cheryl E Ainslie-Waldman
    Authors Affiliations Division of Epidemiology and Community Health, University of Minnesota, Minneapolis Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minnesota Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania Duke NUS Graduate Medical School Singapore, Singapore Saw Swee Hock School of Public Health and Department of Medicine, National University of Singapore, Singapore National Registry of Diseases Office, Health Promotion Board and Department of Gastroenterology and Hepatology, National University Health System, Singapore
    Cancer Epidemiol Biomarkers Prev 23:638-47. 2014
    ..Observational data are lacking among high-risk populations with sufficient regular coffee consumption...
  22. pmc Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer
    Jian Min Yuan
    Authors Affiliations Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
    Cancer Res 74:401-11. 2014
    ....
  23. pmc Serum estrogen receptor bioactivity and breast cancer risk among postmenopausal women
    Vanessa W Lim
    Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore National Registry of Diseases Office, Ministry of Health, Singapore 168937, Singapore Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, USA Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15232, USA Duke NUS Graduate Medical School Singapore, 8 College Road, Singapore 169857, Singapore Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore
    Endocr Relat Cancer 21:263-73. 2014
    ..Factor(s) contributing to increased ERα-mediated estrogenic bioactivity in serum and its role as a predictor for breast cancer risk need to be validated in future studies. ..
  24. pmc Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study
    Zhanghua Chen
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 9:e87762. 2014
    ..We tested whether previously identified T2D-associated single nucleotide polymorphisms (SNPs) replicate and whether SNPs in regions near known T2D SNPs were associated with T2D within the Singapore Chinese Health Study...
  25. pmc Body mass index and risk of pancreatic cancer in a Chinese population
    Seema Untawale
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America Tacoma Pierce County Health Department, Tacoma, Washington, United States of America
    PLoS ONE 9:e85149. 2014
    ..3). In conclusion, Singaporean Chinese who were underweight with a history of smoking had an increased risk of developing pancreatic cancer, whereas there was no significant association between BMI and pancreatic cancer in never smokers...
  26. pmc Dietary soy intake is not associated with risk of cardiovascular disease mortality in Singapore Chinese adults
    Mohammad Talaei
    Saw Swee Hock School of Public Health and
    J Nutr 144:921-8. 2014
    ..However, a slightly increased risk associated with high soy protein intake in men cannot be excluded and requires further investigation. ..
  27. pmc Cigarette smoking and risk of total knee replacement for severe osteoarthritis among Chinese in Singapore--the Singapore Chinese health study
    Y Y Leung
    Duke NUS Graduate Medical School Singapore, Singapore Department of Rheumatology and Immunology, Singapore General Hospital, Singapore Electronic address
    Osteoarthritis Cartilage 22:764-70. 2014
    ..We examined smoking status, duration, dosage and cessation in association with risk of total knee replacement (TKR) for severe knee OA among elderly Chinese in Singapore...
  28. pmc Adherence to a vegetable-fruit-soy dietary pattern or the Alternative Healthy Eating Index is associated with lower hip fracture risk among Singapore Chinese
    Zhaoli Dai
    Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
    J Nutr 144:511-8. 2014
    ..68; 95% CI: 0.58, 0.79) for the AHEI 2010. The MDS pattern score was not associated with hip fracture risk. An Asian diet rich in plant-based foods, namely vegetables, fruit, and legumes such as soy, may reduce the risk of hip fracture. ..
  29. ncbi Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population
    Karol Estrada
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston3Department of Medicine, Harvard Medical School, Boston, Massachusetts
    JAMA 311:2305-14. 2014
    ..Latino populations have one of the highest prevalences of type 2 diabetes worldwide...
  30. pmc Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia: a pooled analysis of 21 cohorts
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS Med 11:e1001631. 2014
    ..Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest...
  31. pmc Coffee, alcohol and other beverages in relation to cirrhosis mortality: the Singapore Chinese Health Study
    George Boon Bee Goh
    Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore
    Hepatology 60:661-9. 2014
    ..The consumption of black tea, green tea, fruit juices, or soft drinks was not associated with risk of cirrhosis death...
  32. pmc Sleep duration and risk of stroke mortality among Chinese adults: Singapore Chinese health study
    An Pan
    From the Saw Swee Hock School of Public Health A P, W P K and Yong Loo Lin School of Medicine A P, National University of Singapore and National University Health System, Singapore, Singapore Duke NUS Graduate Medical School, Singapore, Singapore W P K Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore D A D S Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, PA J M Y and Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, PA J M Y
    Stroke 45:1620-5. 2014
    ..Prospective relation between sleep duration and stroke risk is less studied, particularly in Asians. We examined the association between sleep duration and stroke mortality among Chinese adults...
  33. pmc Impact of postdiagnosis smoking on long-term survival of cancer patients: the Shanghai cohort study
    Li Tao
    Authors Affiliations Cancer Prevention Institute of California, Fremont, California Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania and Department of Epidemiology, Shanghai Cancer Institute and Cancer Institute of Shanghai Jiaotong University, XuHui, Shanghai, China
    Cancer Epidemiol Biomarkers Prev 22:2404-11. 2013
    ..Cancer is the number one cause of death among men in China. Cigarette smoking is the most preventable cause of cancer. Data on the impact of continued smoking after cancer diagnosis on survival of patients with cancer are sparse...
  34. pmc Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York, NY, USA
    BMJ 347:f5446. 2013
    ..To evaluate the association between body mass index and mortality from overall cardiovascular disease and specific subtypes of cardiovascular disease in east and south Asians...
  35. pmc Cancer prevention by green tea: evidence from epidemiologic studies
    Jian Min Yuan
    University of Pittsburgh Cancer Institute and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
    Am J Clin Nutr 98:1676S-1681S. 2013
    ..Large randomized intervention trials on the efficacy of green tea polyphenols or extracts are required before a recommendation for green tea consumption for cancer prevention should be made. ..
  36. pmc Diabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study
    W P Koh
    Duke NUS Graduate Medical School Singapore, Singapore
    Br J Cancer 108:1182-8. 2013
    ..Data from prospective studies on diabetes and risk of HCC in at-risk populations due to high prevalence of viral hepatitis in southeast Asia are sparse...
  37. pmc Knowledge and behaviors toward hepatitis B and the hepatitis B vaccine in the Laotian community in Minnesota
    Ma Xiong
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S 2nd Street, Suite 300, Minneapolis, MN 55454, USA
    J Immigr Minor Health 15:771-8. 2013
    ..8 %) of those individuals received all three doses. This study outlines gaps in knowledge and resources that could address the staggering HBV disparity in this community. ..
  38. pmc Green and black tea in relation to gynecologic cancers
    Lesley M Butler
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523 1681, USA
    Mol Nutr Food Res 55:931-40. 2011
    ....
  39. pmc Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers
    Jian Min Yuan
    Masonic Cancer Center, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Res 71:6749-57. 2011
    ..023) after adjustment for self-reported smoking intensity and duration and urinary total NNAL and total cotinine. This study also confirmed that urinary total NNAL and total cotinine are independently related to lung cancer risk...
  40. pmc Dietary patterns and incident type 2 diabetes in chinese men and women: the singapore chinese health study
    Andrew O Odegaard
    Division of Epidemiology and CommunityHealth, University ofMinnesota, Minneapolis, Minnesota, USA
    Diabetes Care 34:880-5. 2011
    ..To empirically derive dietary patterns and examine their association with incident type 2 diabetes...
  41. pmc Tea and cancer prevention: epidemiological studies
    Jian Min Yuan
    The Masonic Cancer Center, and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 425 East River Road, 554 MCRB, Minneapolis, MN 55455, USA
    Pharmacol Res 64:123-35. 2011
    ..Future prospective observational studies with biomarkers of exposure and phase III clinical trials are required to provide definitive evidence for the hypothesized beneficial effect of tea consumption on cancer formation in humans...
  42. pmc Green tea and breast cancer
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Mol Nutr Food Res 55:921-30. 2011
    ..Results from these biomarker studies are also inconclusive. Limitations of observational studies and areas of further investigations are discussed...
  43. pmc Omega-3 fatty acids and incident type 2 diabetes: the Singapore Chinese Health Study
    Diana P Brostow
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
    Am J Clin Nutr 94:520-6. 2011
    ..The role of omega-3 (n-3) fatty acids (FAs) in the development of type 2 diabetes is uncertain, especially with regard to any differential influence of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)...
  44. pmc Soy intake and risk of type 2 diabetes in Chinese Singaporeans [corrected]
    Noel T Mueller
    Division of Epidemiology and Community Health, University of Minnesota, 1300 South 2nd St, Suite 300, Minneapolis, MN 55454, USA
    Eur J Nutr 51:1033-40. 2012
    ..To examine the association between soy products and their components, isoflavones and protein, and incident type 2 diabetes in a population with varied soy intake and high rates of diabetes...
  45. pmc Green tea and prevention of esophageal and lung cancers
    Jian Min Yuan
    University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA
    Mol Nutr Food Res 55:886-904. 2011
    ....
  46. pmc Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers
    Jian Min Yuan
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 32:1366-71. 2011
    ..These findings along with results of previous studies in laboratory animals support a significant and unique role of NNN in esophageal carcinogenesis in humans...
  47. pmc Glutathione S-transferase (GST) gene polymorphisms, cigarette smoking and colorectal cancer risk among Chinese in Singapore
    Woon Puay Koh
    Department of Epidemiology and Public Health, National University of Singapore, Singapore
    Carcinogenesis 32:1507-11. 2011
    ..Our data indicate an important role for GST enzymes in the detoxification of colorectal carcinogens in tobacco smoke...
  48. pmc Body mass index and risk of colorectal cancer in Chinese Singaporeans: the Singapore Chinese Health Study
    Andrew O Odegaard
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Cancer 117:3841-9. 2011
    ..5 kg/m(2)) in any population...
  49. pmc Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium
    Paolo Boffetta
    Mount Sinai School of Medicine, The Tisch Cancer Institute, New York, New York, United States of America
    PLoS ONE 6:e19930. 2011
    ..The shape of the association of overweight and obesity with diabetes risk and its overall impact have not been adequately studied in Asia...
  50. pmc Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer risk among Chinese women in Singapore
    Woon Puay Koh
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore
    Breast Cancer Res Treat 130:1011-9. 2011
    ....
  51. ncbi Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
    Li Dong Wang
    Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China
    Nat Genet 42:759-63. 2010
    ..PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA...
  52. pmc Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China
    Kristin A Moy
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Epidemiol Biomarkers Prev 19:2287-97. 2010
    ..Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship are sparse...
  53. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
    ..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China...
  54. pmc DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes
    Gwendoline Nauwelaers
    Institut de Recherche en Santé Environnement Travail, EA4427 SeRAIC, Université Rennes 1, IFR 140, 2 Avenue du Pr L Bernard, 35043 Rennes, France
    Chem Res Toxicol 24:913-25. 2011
    ..The possible causal role of AαC in tobacco-associated cancers warrants investigation...
  55. pmc Combined lifestyle factors and cardiovascular disease mortality in Chinese men and women: the Singapore Chinese health study
    Andrew O Odegaard
    MPH, University of Minnesota, School of Public Health, Division of Epidemiology and Community Health, 1300 S 2nd St, Ste 300, Minneapolis MN, 55454, USA
    Circulation 124:2847-54. 2011
    ..Lifestyle factors directly influence cardiovascular disease (CVD) risk, yet little research has examined the association of combined lifestyle factors with CVD mortality, especially in Asian populations...
  56. pmc Plasma vitamin E and coenzyme Q10 are not associated with a lower risk of acute myocardial infarction in Singapore Chinese adults
    Nasheen Naidoo
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    J Nutr 142:1046-52. 2012
    ..In contrast, plasma δ-tocopherol concentrations were associated with a higher risk of AMI. Our findings do not support a role of higher vitamin E or CoQ10 intakes in the prevention of AMI...
  57. pmc Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Int J Cancer 132:891-6. 2013
    ..Melatonin levels derived from randomly timed spot urine are unrelated to breast cancer. Randomly timed, spot urine-derived melatonin levels are noninformative as surrogates of nocturnal melatonin production...
  58. pmc Serum free estradiol and estrogen receptor-α mediated activity are related to decreased incident hip fractures in older women
    Vanessa W Lim
    Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Bone 50:1311-6. 2012
    ..High levels of free estradiol and ERα-mediated estrogen activity in sera were associated with reduced hip fracture risk in Chinese postmenopausal women...
  59. pmc Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Hum Mol Genet 21:2132-41. 2012
    ..Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants...
  60. pmc Cytochrome P4501A2 phenotype and bladder cancer risk: The Shanghai bladder cancer study
    Li Tao
    Masonic Cancer Center, University of Minnesota, MN, USA
    Int J Cancer 130:1174-83. 2012
    ..The findings of our study demonstrate that CYP1A2 phenotype may be an important contributing factor in the development of smoking-related bladder cancer in humans...
  61. pmc Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers
    Jian Min Yuan
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Carcinogenesis 33:804-9. 2012
    ....
  62. pmc Mitochondrial copy number is associated with colorectal cancer risk
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 21:1574-81. 2012
    ..Quantitative changes in human mitochondrial DNA (mtDNA) copy number have been implicated in various cancer types. Data from prospective cohort studies on mtDNA copy number and colorectal cancer risk have been lacking...
  63. pmc Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Norris Cancer Center, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 21:635-44. 2012
    ..We investigated the interrelations of soy, PPARγ, and mammographic density, a biomarker of breast cancer risk in a cross-sectional study of 2,038 women who were members of the population-based Singapore Chinese Health Study Cohort...
  64. pmc Green and black tea intake in relation to prostate cancer risk among Singapore Chinese
    Julia A Montague
    Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA
    Cancer Causes Control 23:1635-41. 2012
    ..In a population-based, prospective cohort study of Chinese men in Singapore, we investigated the relationship between green and black tea intake and prostate cancer risk...
  65. pmc Age at menarche and cardiovascular disease mortality in Singaporean Chinese women: the Singapore Chinese Health Study
    Noel T Mueller
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA
    Ann Epidemiol 22:717-22. 2012
    ..To examine whether age at menarche was inversely associated with cardiovascular disease (CVD) mortality in Singaporean Chinese women...
  66. pmc Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine--a pooled analysis of over 500,000 subjects in the Asia Cohort Consortium
    P Boffetta
    The Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Oncol 23:1894-8. 2012
    ..The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States...
  67. pmc Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore
    Kim Robien
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55455, USA
    Br J Nutr 109:493-502. 2013
    ..Dietary vitamin D intake, hours spent indoors at work and genetic variation in CYP2R1, CYP3A4 and GC are significant predictors of 25(OH)D concentrations among Singapore Chinese...
  68. ncbi Tobacco smoke biomarkers and cancer risk among male smokers in the Shanghai cohort study
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States Electronic address
    Cancer Lett 334:34-8. 2013
    ..Therefore, these biomarkers have the potential to become part of a cancer risk prediction algorithm for smokers. ..
  69. pmc Association of Caucasian-identified variants with colorectal cancer risk in Singapore Chinese
    Lai Fun Thean
    Department of Colorectal Surgery, Singapore General Hospital, Singapore
    PLoS ONE 7:e42407. 2012
    ..Genome-wide association studies (GWAS) in Caucasians have identified fourteen index single nucleotide polymorphisms (iSNPs) that influence colorectal cancer (CRC) risk...
  70. pmc Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium
    Brenda M Birmann
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 120:4929-37. 2012
    ....
  71. pmc Western-style fast food intake and cardiometabolic risk in an Eastern country
    Andrew O Odegaard
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, 55454, USA
    Circulation 126:182-8. 2012
    ..Western-style fast food contributes to a dietary pattern portending poor cardiometabolic health in the United States. With globalization, this way of eating is becoming more common in developing and recently developed populations...
  72. pmc Calcium intake increases risk of prostate cancer among Singapore Chinese
    Lesley M Butler
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1681, USA
    Cancer Res 70:4941-8. 2010
    ..03; 95% confidence interval, 1.23-3.34; P for trend = 0.01) for men with a below median body mass index (22.9 kg/m(2)). Dietary calcium might be a risk factor for prostate cancer even at relatively low intake...