Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior

Summary

Principal Investigator: Kimberly Yolton
Abstract: DESCRIPTION (provided by applicant): Polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl chemicals (PFCs, including perfluorooctane sulfonic acid [PFOS] and perfluorooctanoic acid [PFOA]) are persistent organic chemicals that were introduced several decades ago. Animal studies and limited human studies of PBDEs and PFCs have found evidence for developmental neurotoxicity in children, including thyroid hormone disruption, hyperactivity, delay in neuromotor maturation, and impaired cognition. Although these chemicals are being phased out, humans will still be exposed to PBDEs and PFCs in the environment for decades because these compounds were widely used as flame retardants and surfactants in consumer products. To address the potential adverse health risks of PBDEs and PFCs on fetal, infant, and child neurobehavioral development, the investigators will systematically examine their associations with thyroid function, cognition, learning and memory, motor skills, attention and executive function, and behavior from age 1 to 8 years. The long-term goal is to quantify the roles of PBDE and PFC exposures on child neurobehavior and to inform future prevention efforts. The three specific aims are to: 1) investigate the associations between prenatal and postnatal exposures to PBDEs and thyroid hormones and child neurobehavior;2) examine the associations between prenatal and postnatal exposures to PFCs and thyroid hormones and child neurobehavior;and 3) assess the environmental exposure to PBDEs through transplacental and lactational routes and indoor dust in children. The investigators will test these associations in the Health Outcomes and Measures of the Environment (HOME) Study, an ongoing NIEHS-funded longitudinal birth cohort of 398 women and their children with current follow-up to 5 years. The investigators will extend the cohort to include an age 8 follow-up clinical visit with comprehensive neurobehavior assessments. The investigators will examine the PBDE and PFC exposures at different developmental stages (in utero at 16 weeks of gestation, ages 3, 5, and 8 years) and child neurobehavior measured at 1, 2, 3, 4, 5, and 8 years using stored serum samples. This longitudinal study will allow the investigators to determine the dose response, windows of susceptibility, and persistence of the association. We will also examine the contribution of PBDE exposures from house dust in a subset of children who have complete sample collection of maternal serum and child serum at 1, 2, and 3 years, along with extensive measures of mouthing behaviors. This research is closely related to the NIH mission to investigate prevalent environmental toxicants and children's neurodevelopment.
Funding Period: 2011-08-23 - 2016-04-30
more information: NIH RePORT

Top Publications

  1. pmc Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study
    Joseph M Braun
    Department of Epidemiology, Brown University, Providence, Rhode Island, USA
    Environ Health Perspect 122:513-20. 2014
  2. ncbi Brief report: are autistic-behaviors in children related to prenatal vitamin use and maternal whole blood folate concentrations?
    Joseph M Braun
    Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, 02912, USA
    J Autism Dev Disord 44:2602-7. 2014
  3. pmc Serum cotinine and whole blood folate concentrations in pregnancy
    Adila Prasodjo
    Department of Epidemiology, Brown University School of Public Health, Providence, RI
    Ann Epidemiol 24:498-503.e1. 2014

Detail Information

Publications3

  1. pmc Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study
    Joseph M Braun
    Department of Epidemiology, Brown University, Providence, Rhode Island, USA
    Environ Health Perspect 122:513-20. 2014
    ..Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult...
  2. ncbi Brief report: are autistic-behaviors in children related to prenatal vitamin use and maternal whole blood folate concentrations?
    Joseph M Braun
    Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, 02912, USA
    J Autism Dev Disord 44:2602-7. 2014
    ..The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors...
  3. pmc Serum cotinine and whole blood folate concentrations in pregnancy
    Adila Prasodjo
    Department of Epidemiology, Brown University School of Public Health, Providence, RI
    Ann Epidemiol 24:498-503.e1. 2014
    ..Prenatal tobacco smoke exposure may be associated with low maternal folate levels that increase the risk of adverse infant and child health outcomes by reducing folate availability during fetal development...

Research Grants31

  1. Beryllium: Exposure Immune and Genetic Mechanisms
    Lee S Newman; Fiscal Year: 2013
    ..The productivity and continuance demonstrate quality, commitment and ability to work together. PROGRAM AS INTERGRATED EFFORT ..
  2. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
    ..We plan to build research capacity in the Center and other organizations, enhance careers of new investigators, and make key findings accessible to researchers, policy makers, practitioners, and the public. ..
  3. Early-life phthalate exposure, thyroid function and child cognitive development
    ROBIN MARJORIE WHYATT; Fiscal Year: 2013
    ....
  4. Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic Markers
    Isaac N Pessah; Fiscal Year: 2013
    ....
  5. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..These data and dietary studies in the last Aim will provide a scientific basis for risk assessment and advice for stakeholders with the ultimate goal to protect highly-exposed individuals and populations. ..
  6. TOXIC SUBSTANCES IN THE ENVIRONMENT
    Martyn T Smith; Fiscal Year: 2013
    ..The program will be overseen and coordinated by an Administration core (A). ..
  7. DDT &PBDE exposure, puberty onset and neurodevelopment in Mexican-American girls
    Brenda Eskenazi; Fiscal Year: 2013
    ..abstract_text> ..