International Gap Junction Conference 2013

Summary

Principal Investigator: Robert G Gourdie
Abstract: DESCRIPTION (provided by applicant): Virtually all cells in the human body form gap junctions. These structures are membrane channels composed of proteins (connexins) that connect apposing cells and provide for the direct movement of small molecules between cells. Over 20 human diseases are linked to mutations in connexins. The most well-known role of cell communication is in synchronizing the beating of myocardial cells within the heart. Disruption of cell communication in the heart is strongly linked to arrhythmia and sudden death in a range of cardiac diseases. More recently, a structurally related group of proteins called pannexins have been found to be critical to the vasculature in health and disease. With the rapid developments in the field, investigators have found recurring targeted scientific meetings to be especially valuable forums for the exchange of ideas and techniques that pave the way for scientific discovery. This application requests funds for the 2013 International Gap Junction Conference, to be held in Charleston, South Carolina July 13- 18. This conference represents the 14th in a unique series of biennial interdisciplinary meetings focused on gap junctions and allied signaling mechanisms. The NHLBI funded an R13 in support of the International Gap Junction Conference the last time it was convened in the USA in 2009. The overall goals of this meeting are to achieve a better understanding of connexins, pannexins, and gap junctions in both normal and diseased states, with the overarching goal of identifying novel pharmacological approaches to target these proteins. The cardiovascular system will be a particular emphasis of the meeting. The meeting organizers Drs. Gourdie, Koval, Isakson and Mauldin have a strong track record in conference organization. Drs Gourdie, Koval and Isakson are established investigators in the area of connexin, innexin and/or pannexin biology. The meeting will place particular emphasis on innovative developments in the field and uses a number of novel approaches in promoting the IGJC meeting. A majority of the requested funds are in support of student and trainee participation. Additionally the meeting will provide a continuing forum for the fostering of productive collaborations and attracting students and postdoctoral trainees from diverse backgrounds to the gap junction field.
Funding Period: 2013-05-01 - 2014-03-31
more information: NIH RePORT

Research Grants

  1. DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM
    Reese T Jones; Fiscal Year: 2013
  2. INNATE AND ADAPTIVE IMMUNE RESPONSES IN TH2-HIGH ASTHMA
    John V Fahy; Fiscal Year: 2013
  3. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth H Cowan; Fiscal Year: 2013
  4. Modulation of MG53 Function in Cardiac Membrane Repair
    Jianjie Ma; Fiscal Year: 2013
  5. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
  6. JHU-UMD Diabetes Research Center
    Fredric E Wondisford; Fiscal Year: 2013
  7. Northeast Biodefense Center
    W Ian Lipkin; Fiscal Year: 2013
  8. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
  9. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
  10. Superfund Metal Mixtures, Biomarkers and Neurodevelopment
    David C Bellinger; Fiscal Year: 2013

Detail Information

Research Grants30

  1. DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM
    Reese T Jones; Fiscal Year: 2013
    ..abstract_text> ..
  2. INNATE AND ADAPTIVE IMMUNE RESPONSES IN TH2-HIGH ASTHMA
    John V Fahy; Fiscal Year: 2013
    ..Including studies in human biospecimens in a PPG that promises to advance understanding of airway TH2 inflammation in ways that are highly relevant to patients with asthma. ..
  3. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth H Cowan; Fiscal Year: 2013
    ....
  4. Modulation of MG53 Function in Cardiac Membrane Repair
    Jianjie Ma; Fiscal Year: 2013
    ..Our studies will have broader impact on the basic biology of cell membrane repair and tissue regeneration, and have potential translational value for treatment of cardiovascular diseases. ..
  5. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
    ..S. public health. ..
  6. JHU-UMD Diabetes Research Center
    Fredric E Wondisford; Fiscal Year: 2013
    ..The Enrichment Program will facilitate the interaction within and between Johns Hopkins University and the University of Maryland. ..
  7. Northeast Biodefense Center
    W Ian Lipkin; Fiscal Year: 2013
    ..As a Center based in a School of Public Health and a State Department of Health, the NBC has a firm commitment to and practical understanding of Emergency Preparedness. ..
  8. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
    ..This project seeks to understand the pathophysiology of lipotoxic cardiomyopathy that leads to arrhythmias and sudden death by using animal models. ..
  9. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
    ..This Program is highly relevant to Superfund by addressing high-priority chemicals and by focusing on mechanisms underlying health effects, exposure assessment, and remediation to mitigate exposure and toxicity. ..
  10. Superfund Metal Mixtures, Biomarkers and Neurodevelopment
    David C Bellinger; Fiscal Year: 2013
    ..Aim 4- To promote rapid dissemination of significant research findings;and Aim 5- Compliance- To ensure compliance with NIH requirements for data and resource-sharing and the human and animal institutional review board requirements ..
  11. 2013/2015 Glycobiology Gordon Research Conference &Gordon Research Seminar
    Kelley W Moremen; Fiscal Year: 2013
    ..The meeting will focus on the latest hot-topic research areas at the frontiers of biomedical research and bring together the leading and developing scientists in the field. ..
  12. STUDIES OF JOINT AGING AND OSTEOARTHRITIS
    Martin K Lotz; Fiscal Year: 2013
    ..Sah) will analyze biomechanical mechanisms of early and advanced cartilage degeneration and determine consequences for chondrocyte function and survival. ..