FASEB SRC on Ion Channel Regulation

Summary

Principal Investigator: Geoffrey W Abbott
Abstract: DESCRIPTION (provided by applicant): Ion channels and transporters are ought to account for 1% of human genes, and their disruption by inherited mutations is intensively studied as a means not only to learn more about their physiology, but also to develop therapeutic strategies to treat inherited 'channelopathies'and also to treat or avoid more widespread disorders in which channels are causative and/or potential therapeutic targets, e.g., drug- induced cardiac arrhythmias, and epilepsy. Study of mutant ion channels has permitted an unprecedented understanding of the molecular basis of disease, as single mutant proteins can be studied using single channel patch-clamp techniques to determine the precise molecular etiology of channelopathies and created a platform for the treatment of channel disorders through the judicious application in new ways of clinically available drugs targeting ion channels. A major and ongoing step forward in our understanding of channelopathies has been the discovery of a number of regulatory proteins, which modulate ion channel function and which, when mutated in inherited disorders, also disrupt native ionic currents and underlies a range of pathologies. This conference, with its theme of ion channel regulation, encompasses this relatively new aspect of inherited channelopathies. This theme provides outstanding opportunities for collaboration, cross-disciplinary interactions, and interdisciplinary and multidisciplinary research training. Ths is an application for partial support of the 6th biennial FASEB Summer Research Conference on Ion Channel Regulation. The conference will be held June 23-28, 2013 at the Sheraton Resort, Nassau, Bahamas. Funds from this grant will be used exclusively to support registration fees, lodging, meals and travel to the conference for 20 trainees (graduate students, postdoctoral fellows). This meeting is designed to highlight the latest discoveries related to ion channel regulation and introduce novel conceptual and technological approaches. The goal of the meeting is to promote new collaborations and directions for research on channel regulation and to foster the development of junior investigators by offering them the chance to learn from, and develop relationships with, leading researchers in the field. This conference has previously fostered new cross-discipline collaborations among scientific groups and has stimulated more rapid advances because of synergistic interactions that occurred during and after the meeting. The Co-chairs of the 2013 conference will be Dr. Geoffrey W. Abbott (University of California, Irvine) and Dr. Geoffrey S. Pitt (Duke University), both recognized leaders in ion channel biology with an emphasis on channel regulation. The Program consists of nine scientific sessions, 1 keynote address, and a panel session titled "Challenges and Opportunities for Women in Science". Most sessions were organized around general themes rather than ion channel subtype, to foster crosstalk between fields typically kept separate in traditional conferences. Several of the planned talks focus upon the molecular and cellular basis of rare diseases (channelopathies). Of the thirty-seven speakers giving full talks, 11 are women, (30% of speakers;5 of 9 session chairs are also women), and 2 are members of groups underrepresented in science. Eight short talks will be selected from submitted abstracts and invited early stage investigators, with an emphasis on inviting women, minorities underrepresented in science and trainees;we will also work with institutions within the Caribbean to encourage their participation, thereby encouraging novel collaborations. The conference venue has appropriate facilities for disabled attendees.
Funding Period: 2013-06-01 - 2014-05-31
more information: NIH RePORT

Research Grants

  1. DIABETES AND ENDOCRINOLOGY RESEARCH CENTER
    Domenico Accili; Fiscal Year: 2013
  2. TOXIC SUBSTANCES IN THE ENVIRONMENT
    Martyn T Smith; Fiscal Year: 2013
  3. Endocannabinoid Metabolic Enzymes: Structure, Function, In Vivo Inhibition
    Benjamin F Cravatt; Fiscal Year: 2013
  4. Massachusetts Alzheimer's Disease Research Center
    Bradley T Hyman; Fiscal Year: 2013
  5. Pacific NorthWest Regional Center of Excellence (PNWRCE)
    Jay A Nelson; Fiscal Year: 2013
  6. Molecular motors in cell biology
    Yale E Goldman; Fiscal Year: 2013
  7. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
  8. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
  9. Strategies for Improved Shock Wave Lithotripsy
    JAMES ALEXANDER MCATEER; Fiscal Year: 2013

Detail Information

Research Grants30

  1. DIABETES AND ENDOCRINOLOGY RESEARCH CENTER
    Domenico Accili; Fiscal Year: 2013
    ....
  2. TOXIC SUBSTANCES IN THE ENVIRONMENT
    Martyn T Smith; Fiscal Year: 2013
    ..The program will be overseen and coordinated by an Administration core (A). ..
  3. Endocannabinoid Metabolic Enzymes: Structure, Function, In Vivo Inhibition
    Benjamin F Cravatt; Fiscal Year: 2013
    ..abstract_text> ..
  4. Massachusetts Alzheimer's Disease Research Center
    Bradley T Hyman; Fiscal Year: 2013
    ..Going forward, the MADRC will continue to expand its clinical and neuropathological resources, its innovative training and scientific programs directed toward AD research. ..
  5. Pacific NorthWest Regional Center of Excellence (PNWRCE)
    Jay A Nelson; Fiscal Year: 2013
    ..pseudomallei host pathogen response during both the septicemic as well as the intracellular phases of the disease. ..
  6. Molecular motors in cell biology
    Yale E Goldman; Fiscal Year: 2013
    ..We anticipate that the proposed work will take us significantly further toward our goal of understanding motility in the normal and pathological function of cells. ..
  7. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..These data and dietary studies in the last Aim will provide a scientific basis for risk assessment and advice for stakeholders with the ultimate goal to protect highly-exposed individuals and populations. ..
  8. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
    ..S. public health. ..
  9. Strategies for Improved Shock Wave Lithotripsy
    JAMES ALEXANDER MCATEER; Fiscal Year: 2013
    ..and the session can be ended * Determine the mechanism by which cavitation within a vessel causes hemorrhage * Develop numerical models to understand the role of cavitation and non-cavitational mechanisms in causing tissue damage ..