IRON STATUS AND RISK OF CHD AND COLON CANCER

Summary

Principal Investigator: J Ma
Abstract: DESCRIPTION: (Adapted from Investigator's Abstract) The investigators propose to examine prospectively the relation between iron status (intake, body stores, and genetic susceptibility for hemochromatosis) and risk of myocardial infarction (MI) and colorectal cancer in three large cohorts. Iron intake was assessed by semiquantitative food frequency questionnaire (SFFQ) in 1980 in the Nurses' Health Study (NHS, n=121,700 women) and in 1986 in the NHS and in the Health Professionals Follow-up Study (HPFS, n=51,529 men). Blood samples were collected in both of these cohorts: from the NHS in 1989-90 (n=32,825 women), and the HPFS in 1993-94 (n=18,000 men). In addition, samples also were collected from participants in the Physicians' Health Study in 1982 (PHS, n=14,916 men). These men and women initially free of cardiovascular disease and cancer and have been followed prospectively for the occurrence of cardiovascular disease and cancer. The investigators plan to assay the samples, in a nested case-control design, for biomarkers of body iron stores (iron, total iron binding capacity, ferritin) and genetic marker of hemochromatosis, an inherited disease of iron overload (C282Y, a missense mutation in HLA-H gene). The iron-CHD/cancer hypotheses have been supported by laboratory and animal studies, but findings from small, less comprehensive epidemiologic studies are inconsistent. They propose to evaluate the individual associations of intake, biomarker levels, and genotype with risk of MI and colorectal cancer, as well as the combined effects. Further, they will evaluate other dietary and lifestyle factors that may account for or modify the association between iron and MI/colorectal cancer. The ongoing three cohorts will provide high yield follow-up participation and high quality end-point verification in addition to information on important variables (e.g., smoking, vitamin supplement use, dietary factors) for the proposed study. These analyses will take advantage of existing blood banks of these well-characterized cohorts, and part of the plasma ferritin measurements (the NHS and PHS) are funded through other sources. The investigators state that hence, this application provides a well-focused, efficient cost-effective, and comprehensive approach to evaluate the hypothesized but unproven role of iron as a risk factor for future cardiovascular disease and cancer.
Funding Period: 1998-01-01 - 2003-12-31
more information: NIH RePORT

Top Publications

  1. pmc Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Lancet Oncol 9:1039-47. 2008
  2. ncbi High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status
    Ling Hao
    Institute of Reproductive and Child Health, Peking University, Beijing 100083, China, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Nutr 137:407-13. 2007
  3. ncbi Vitamin B-12 deficiency is prevalent in 35- to 64-year-old Chinese adults
    Ling Hao
    Institute of Reproductive and Child Health, Peking University, Beijing, 100083, China
    J Nutr 137:1278-85. 2007
  4. pmc Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Arch Intern Med 168:861-6. 2008
  5. pmc Excessive body iron stores are not associated with risk of coronary heart disease in women
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 138:2436-41. 2008

Scientific Experts

  • Francine Grodstein
  • Qi Sun
  • Jing Ma
  • Ling Hao
  • Meir J Stampfer
  • Walter C Willett
  • JiangHui Zhu
  • Yihua Tian
  • Zhu Li
  • Ed Giovannucci
  • Lorelei Mucci
  • Michael Pollak
  • Paul L Nguyen
  • Haojie Li
  • Weiliang Qiu
  • J Michael Gaziano

Detail Information

Publications5

  1. pmc Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Lancet Oncol 9:1039-47. 2008
    ..We assessed the effect of prediagnostic BMI and plasma C-peptide concentration (reflecting insulin secretion) on prostate cancer-specific mortality after diagnosis...
  2. ncbi High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status
    Ling Hao
    Institute of Reproductive and Child Health, Peking University, Beijing 100083, China, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Nutr 137:407-13. 2007
    ..Low plasma concentrations of folate, vitamins B-12 and B-6, older age, being male, and living in urban areas were all independently associated with elevated tHcy, with low folate as the strongest determinant...
  3. ncbi Vitamin B-12 deficiency is prevalent in 35- to 64-year-old Chinese adults
    Ling Hao
    Institute of Reproductive and Child Health, Peking University, Beijing, 100083, China
    J Nutr 137:1278-85. 2007
    ..Further studies are needed to evaluate the health effects and possible intervention strategies in areas where B-12 vitamin deficiency is common...
  4. pmc Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Arch Intern Med 168:861-6. 2008
    ..We evaluated stroke risk associated with hormone therapy (HT) in younger women, in recently menopausal women, and in older women...
  5. pmc Excessive body iron stores are not associated with risk of coronary heart disease in women
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 138:2436-41. 2008
    ..05 (0.62, 1.77), 1.19 (0.69, 2.03), and 1.05 (0.60, 1.85; P-trend = 0.90) across quartiles. Our data do not support the hypothesis that excessive body iron stores are associated with risk of CHD...