Neural Correlates and Modifiers of Cognitive Aging

Summary

Principal Investigator: Naftali Raz
Abstract: The goals of this continuing project are 1. Aim 1. To describe the course of differential brain aging vyith a focus on the best-case-scenario naturalistic study of successful aging. With that focus, the study will complement existing large-scale longitudinal investigations of typical geriatric samples. Our objective is to examine the closest approximation to successful physiological aging to be found in an unselected human population. 2. Aim 2, To gain insights into mechanisms of age-related differential brain shrinkage by examining changes in microstructure of the white matter and indirect indices of regional brain iron content. 3. Aim 3. To evaluate the links between age-related regional brain changes (volume, diffusion and magnetization properties, and iron content) and performance in three cognitive domains with known vulnerability to aging: episodic memory, executive functions, and speed of processing. 4. Aim 4. To examine the effect of vascular risk factors (physiological and genetic) as modifiers of brain and cognitive aging. We will continue our investigation into the effects of sub-clinical levels of vascular risk conveyed by elevated blood pressure, circulating cardiac risk factors (homocysteine, C-reactive protein), elevated insulin, and genetic variants associated with vascular and metabolic risk (MTHFR C677T, IL1-p C511T, BDNF Val66Met, ACE l/D, ApoEpound4, diabetes risk genes, and polymorphisms related to specific neurotransmitters - acetylcholine, serotonin, dopamine). Aim 5. Common to all listed aims is a longitudinal approach to study of biological and cognitive change with Latent Growth Curves models that allow estimation of the shape of the trajectories of aging. Aim 6. Methodological contributions. During the proposed extension award period, we plan to initiate several methodological investigations, in which we will compared manual volumetry and ROI-based evaluation of white matter integrity with various semi-automated methods, with a hope to improve those methods to the level comparable with the "golden standard."
Funding Period: 1993-09-30 - 2015-05-31
more information: NIH RePORT

Top Publications

  1. pmc Decreased physical activity predicts cognitive dysfunction and reduced cerebral blood flow in heart failure
    Michael L Alosco
    Department of Psychology, Kent State University, Kent, OH, USA
    J Neurol Sci 339:169-75. 2014
  2. pmc Does variability in cognitive performance correlate with frontal brain volume?
    Martin Lövdén
    Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
    Neuroimage 64:209-15. 2013
  3. pmc The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory
    Karen M Rodrigue
    School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, Dallas, TX, USA
    Cereb Cortex 23:1533-41. 2013
  4. ncbi Age-related differences in episodic memory: a synergistic contribution of genetic and physiological vascular risk factors
    Andrew R Bender
    Department of Psychology, Wayne State University, Detroit, Michigan, USA
    Neuropsychology 26:442-50. 2012
  5. pmc Age-related differences in recognition memory for items and associations: contribution of individual differences in working memory and metamemory
    Andrew R Bender
    Department of Psychology and Institute of Gerontology, Wayne State University
    Psychol Aging 27:691-700. 2012
  6. pmc Age-related differences in memory and executive functions in healthy APOE ɛ4 carriers: the contribution of individual differences in prefrontal volumes and systolic blood pressure
    Andrew R Bender
    Department of Psychology and Institute of Gerontology, Wayne State University, United States
    Neuropsychologia 50:704-14. 2012
  7. pmc Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Biochim Biophys Acta 1822:361-9. 2012
  8. pmc Only time will tell: cross-sectional studies offer no solution to the age-brain-cognition triangle: comment on Salthouse (2011)
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, 87 East Ferry Street, Detroit, MI 48202, USA
    Psychol Bull 137:790-5. 2011
  9. pmc Hippocampal subfield volumes: age, vascular risk, and correlation with associative memory
    Yee Lee Shing
    Center for Lifespan Psychology, Max Planck Institute for Human Development Berlin, Germany
    Front Aging Neurosci 3:2. 2011
  10. pmc Age differences in speed of processing are partially mediated by differences in axonal integrity
    S Burgmans
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuroimage 55:1287-97. 2011

Research Grants

  1. CARDIOVASCULAR DYNAMICS AND THEIR CONTROL
    John E Hall; Fiscal Year: 2013
  2. IL-13 and IL-17 dynamics in the asthmatic airway
    Dean Sheppard; Fiscal Year: 2013
  3. Emory Alzheimer's Disease Center
    Allan I Levey; Fiscal Year: 2013
  4. Alzheimer's Disease Research Center
    Thomas J Montine; Fiscal Year: 2013
  5. Defining and Treating Written Language Disabilities
    VIRGINIA WISE BERNINGER; Fiscal Year: 2013
  6. HEALTHY AGING AND SENILE DEMENTIA
    John Morris; Fiscal Year: 2013
  7. EARLY EVENTS IN ALZHEIMER PATHOGENESIS
    SUE TILTON GRIFFIN; Fiscal Year: 2013
  8. Inflammatory responses of vascular cells
    Paul L Fox; Fiscal Year: 2013
  9. Massachusetts Alzheimer's Disease Research Center
    Bradley T Hyman; Fiscal Year: 2013
  10. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013

Detail Information

Publications60

  1. pmc Decreased physical activity predicts cognitive dysfunction and reduced cerebral blood flow in heart failure
    Michael L Alosco
    Department of Psychology, Kent State University, Kent, OH, USA
    J Neurol Sci 339:169-75. 2014
    ..The current study examined whether reduced physical activity increases risk for cognitive impairment and brain hypoperfusion over time in HF...
  2. pmc Does variability in cognitive performance correlate with frontal brain volume?
    Martin Lövdén
    Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
    Neuroimage 64:209-15. 2013
    ....
  3. pmc The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory
    Karen M Rodrigue
    School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, Dallas, TX, USA
    Cereb Cortex 23:1533-41. 2013
    ..Longitudinal follow-up is needed to test whether altered iron homeostasis in the HC is an early marker for age-related cognitive decline...
  4. ncbi Age-related differences in episodic memory: a synergistic contribution of genetic and physiological vascular risk factors
    Andrew R Bender
    Department of Psychology, Wayne State University, Detroit, Michigan, USA
    Neuropsychology 26:442-50. 2012
    ....
  5. pmc Age-related differences in recognition memory for items and associations: contribution of individual differences in working memory and metamemory
    Andrew R Bender
    Department of Psychology and Institute of Gerontology, Wayne State University
    Psychol Aging 27:691-700. 2012
    ..Thus, maladaptive beliefs about memory in conjunction with reduced cognitive resources account in part for differences in associative memory commonly attributed to aging...
  6. pmc Age-related differences in memory and executive functions in healthy APOE ɛ4 carriers: the contribution of individual differences in prefrontal volumes and systolic blood pressure
    Andrew R Bender
    Department of Psychology and Institute of Gerontology, Wayne State University, United States
    Neuropsychologia 50:704-14. 2012
    ..Thus, even in healthy older carriers of the APOE ɛ4 allele, clinically unremarkable increase in vascular risk may be associated with reduced frontal volumes and impaired cognitive functions...
  7. pmc Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Biochim Biophys Acta 1822:361-9. 2012
    ..This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease...
  8. pmc Only time will tell: cross-sectional studies offer no solution to the age-brain-cognition triangle: comment on Salthouse (2011)
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, 87 East Ferry Street, Detroit, MI 48202, USA
    Psychol Bull 137:790-5. 2011
    ..Mediation models of cross-sectional data represent age-related differences in target variables but fail to approximate time-dependent relations; thus, they do not elucidate the dimensions and dynamics of cognitive aging...
  9. pmc Hippocampal subfield volumes: age, vascular risk, and correlation with associative memory
    Yee Lee Shing
    Center for Lifespan Psychology, Max Planck Institute for Human Development Berlin, Germany
    Front Aging Neurosci 3:2. 2011
    ..We discuss the role of the DG in pattern separation and the formation of discrete memory representations...
  10. pmc Age differences in speed of processing are partially mediated by differences in axonal integrity
    S Burgmans
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuroimage 55:1287-97. 2011
    ..The presence of hypertensive participants did not affect the results. We conclude that in healthy adults, deterioration of axonal integrity and ensuing breech of connectivity may underpin age-related slowing of information processing...
  11. pmc White matter deterioration in 15 months: latent growth curve models in healthy adults
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neurobiol Aging 33:429.e1-5. 2012
    ..Thus, white matter of healthy middle-aged and older adults undergoes significant regional deterioration in a relatively short period, and is negatively affected by vascular risk and lower educational level...
  12. pmc Differential effects of age and history of hypertension on regional brain volumes and iron
    Karen M Rodrigue
    School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA
    Neuroimage 54:750-9. 2011
    ..Thus, iron content as measured by T2* may be a sensitive index of regional brain aging and may reveal declines that are more prominent than gross anatomical shrinkage...
  13. pmc Associative deficit in recognition memory in a lifespan sample of healthy adults
    Andrew R Bender
    Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Psychol Aging 25:940-8. 2010
    ..Sex differences and health factors may modify the associative deficit regardless of age...
  14. pmc Age-related differences in iron content of subcortical nuclei observed in vivo: a meta-analysis
    Ana Daugherty
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neuroimage 70:113-21. 2013
    ..The magnitude of age differences in estimated iron content of the caudate nucleus and putamen partially depended on the method of estimation, but not on the type of design (continuous age vs. extreme age groups)...
  15. ncbi Depressive symptomatology, exercise adherence, and fitness are associated with reduced cognitive performance in heart failure
    Michael L Alosco
    Kent State University, Kent, OH 44242, USA
    J Aging Health 25:459-77. 2013
    ..The current study used structrual equation modeling to examine whether depression adversely impacts cognitive function in HF through its adverse affects on exercise adherence and cardiovascular fitness...
  16. pmc Prefrontal cortex and executive functions in healthy adults: a meta-analysis of structural neuroimaging studies
    Peng Yuan
    Institute of Gerontology and Department of Psychology, Wayne State University, 87 East Ferry St, 226 Knapp Bldg, Detroit, MI 48202, United States
    Neurosci Biobehav Rev 42:180-92. 2014
    ..The results support the "bigger is better" hypothesis of brain-behavior relation in healthy adults and suggest different neural correlates across the neuropsychological tests used to assess executive functions. ..
  17. pmc Turning bias in virtual spatial navigation: age-related differences and neuroanatomical correlates
    Peng Yuan
    Institute of Gerontology and Department of Psychology, Wayne State University, 87 East Ferry Street, 226 Knapp Building, Detroit, MI 48202, United States
    Biol Psychol 96:8-19. 2014
    ..Advanced age was associated with greater rightward turning preference. Men showed greater leftward preference whereas women exhibited stronger rightward bias. ..
  18. ncbi Life-span plasticity of the brain and cognition: from questions to evidence and back
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry Street, Detroit, MI 48202, United States Electronic address
    Neurosci Biobehav Rev 37:2195-200. 2013
    ..The conference honored Margret M. and Paul B. Baltes, the pioneers of life-span developmental psychology who initiated some of the first studies on experience- and training-related changes in cognition across the life span. ..
  19. pmc Cognitive performance in older adults with stable heart failure: longitudinal evidence for stability and improvement
    Michael L Alosco
    a Department of Psychology, Kent State University, Kent, OH, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 21:239-56. 2014
    ....
  20. pmc APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis
    Sabrina Schilling
    Department of Epidemiology, Raymond Poincare Hospital, University of Versailles St Quentin en Yvelines, Versailles, France
    Neurology 81:292-300. 2013
    ..We aimed to examine the association of APOE ε genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds...
  21. ncbi Vascular risk moderates associations between hippocampal subfield volumes and memory
    Andrew R Bender
    Wayne State University, Detroit, MI
    J Cogn Neurosci 25:1851-62. 2013
    ..These findings suggest that relatively small regions of the HC may play a role in age-related memory declines and that vascular risk factors associated with advanced age may modify that relationship. ..
  22. pmc Independent and interactive effects of blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure
    Michael L Alosco
    Department of Psychology, Kent State University, Kent, OH
    J Am Soc Hypertens 7:336-43. 2013
    ..However, the independent and interactive effects of blood pressure and systemic perfusion on brain structure in HF have yet to be investigated...
  23. pmc Differential brain shrinkage over 6 months shows limited association with cognitive practice
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI, USA
    Brain Cogn 82:171-80. 2013
    ..Thus, in healthy adults, differential brain shrinkage can be observed in a narrow time window, vascular risk may aggravate it, and intensive cognitive activity may have a limited effect on it...
  24. ncbi Executive dysfunction is independently associated with reduced functional independence in heart failure
    Michael L Alosco
    Department of Psychology, Kent State University, Kent, OH, USA
    J Clin Nurs 23:829-36. 2014
    ..To examine the independent association between executive function with instrumental activities of daily living and health behaviours in older adults with heart failure...
  25. pmc Critical ages in the life course of the adult brain: nonlinear subcortical aging
    Anders M Fjell
    Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neurobiol Aging 34:2239-47. 2013
    ..91). The main conclusions are that most brain structures do not follow a simple path throughout adult life and that accelerated decline in high age is not the norm of healthy brain aging. ..
  26. pmc Cardiovascular fitness associated with cognitive performance in heart failure patients enrolled in cardiac rehabilitation
    Sarah Garcia
    Department of Psychology, Kent State University, Kent, OH 44242, USA
    BMC Cardiovasc Disord 13:29. 2013
    ....
  27. pmc Poorer physical fitness is associated with reduced structural brain integrity in heart failure
    Michael L Alosco
    Department of Psychology, Kent State University, Kent, OH 44242, USA
    J Neurol Sci 328:51-7. 2013
    ..In heart failure (HF) patients, poor physical fitness may contribute to cognitive dysfunction and we examined the unique contribution of physical fitness to brain structural integrity among patients with HF...
  28. pmc The adverse impact of type 2 diabetes on brain volume in heart failure
    Michael L Alosco
    Department of Psychology, Kent State University, Kent, OH 44242, USA
    J Clin Exp Neuropsychol 35:309-18. 2013
    ..The current study examined whether comorbid T2DM exacerbates brain atrophy in older adults with HF...
  29. pmc Trajectories of brain aging in middle-aged and older adults: regional and individual differences
    Naftali Raz
    Institute of Gerontology, Wayne State University, USA
    Neuroimage 51:501-11. 2010
    ..In corpus callosum, shrinkage rate was greater in persons with hypertension, and in the pons, women and carriers of the ApoEepsilon4 allele exhibited declines not noted in the whole sample...
  30. pmc Biological changes associated with healthy versus pathological aging: a symposium review
    M N Rajah
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada
    Ageing Res Rev 8:140-6. 2009
    ....
  31. pmc Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 23:105-16. 2009
    ..The findings indicate that age-related cognitive performance is differentially affected by distinct genetic factors and their interactions with vascular health status...
  32. pmc Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI, USA
    Neuropsychologia 47:916-27. 2009
    ..The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause...
  33. pmc Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test
    Denise Head
    Department of Psychology, Washington University, St Louis, USA
    Neuropsychologia 47:1200-3. 2009
    ..We conclude that age-related increase in perseveration is indeed differentially dependent on the integrity of prefrontal cortex and on declines in selected cognitive processes dependent on this region...
  34. pmc High consistency of regional cortical thinning in aging across multiple samples
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Olso 0317, Norway
    Cereb Cortex 19:2001-12. 2009
    ..The inferior temporal lobe and anterior cingulate cortices were relatively less affected by age. The results are discussed in relation to leading theories of cognitive aging...
  35. pmc Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation
    Awantika Deshmukh
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, United States
    Biol Psychol 80:240-5. 2009
    ..These findings indicate that hypertension combined with a genetic vascular risk factor may significantly increase risk for cognitive impairment...
  36. pmc Neuroanatomical and cognitive mediators of age-related differences in episodic memory
    Denise Head
    Department of Psychology, Division of Biology and Biomedical Sciences, Washington University in St Louis, MO 63130, USA
    Neuropsychology 22:491-507. 2008
    ..No direct effects of age on episodic memory remained once these factors were taken into account. These analyses highlight the value of a multivariate approach with the understanding of complex relationships in cognitive and brain aging...
  37. pmc Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry
    Kristen M Kennedy
    Institute of Gerontology, Department of Psychology, Wayne State University, Detroit, MI, USA
    Neurobiol Aging 30:1657-76. 2009
    ..It may be beneficial to use VBM as a first-pass strategy, followed by manual measurement of anatomically defined regions...
  38. ncbi Age-related differences in acquisition of perceptual-motor skills: working memory as a mediator
    Kristen M Kennedy
    Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:165-83. 2008
    ..The third model provided the best fit to the data, indicating age differences in simple perceptual-motor skill are partially mediated by more complex abilities...
  39. pmc Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factors
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Cereb Cortex 18:718-26. 2008
    ..VR was independently associated with smaller prefrontal volumes and lower fluid intelligence. Thus, prefrontal and medial-temporal systems may play different roles in age-related differences and changes in cognitive performance...
  40. pmc Brain aging and its modifiers: insights from in vivo neuromorphometry and susceptibility weighted imaging
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
    Ann N Y Acad Sci 1097:84-93. 2007
    ..Future research on brain aging would benefit from combining structural and metabolic techniques in a longitudinal design, as such studies will allow examination of leading-trailing effects of those factors...
  41. ncbi Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, US
    Neuropsychology 21:149-57. 2007
    ..Thus, poor vascular health contributes to age-related declines in brain and cognition, and some of the age-related declines may be limited to persons with elevated vascular risk...
  42. ncbi Fragmented pictures revisited: long-term changes in repetition priming, relation to skill learning, and the role of cognitive resources
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Gerontology 53:148-58. 2007
    ..The common assumption, based on cross-sectional studies, is that these processes are only mildly (if at all) affected by age...
  43. pmc Life span adult faces: norms for age, familiarity, memorability, mood, and picture quality
    Kristen M Kennedy
    Department of Psychology and Institute of Gerontology, Wayne State University, Detroit, Michigan 48202, USA
    Exp Aging Res 35:268-75. 2009
    ..Because the pictures did not differ in any of the measured attributes, the authors provide three balanced sets of face stimuli to researchers desiring normed face stimuli free from age confounds...
  44. pmc Aging, vascular risk, and cognition: blood glucose, pulse pressure, and cognitive performance in healthy adults
    Cheryl L Dahle
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Psychol Aging 24:154-62. 2009
    ....
  45. pmc Cortical gray matter atrophy in healthy aging cannot be explained by undetected incipient cognitive disorders: a comment on Burgmans et al. (2009)
    Anders M Fjell
    Department of Psychology, University of Oslo, Norway, P B 1094 Blindern, 0317 Oslo, Norway
    Neuropsychology 24:258-63; discussion 264-266. 2010
    ..Longitudinally, 1-year atrophy was identified in all tested regions. It is likely that cortical brain atrophy is manifested in cognitively normal elderly without subclinical cognitive disorders...
  46. pmc News of cognitive cure for age-related brain shrinkage is premature: a comment on Burgmans et al. (2009)
    Naftali Raz
    Wayne State University
    Neuropsychology 24:255-7. 2010
    ..In this comment accompanied by reanalysis of previously published data, we argue that these claims are incorrect on logical, methodological, and empirical grounds...
  47. pmc Episodic memory and organizational strategy in free recall in unipolar depression: the role of cognitive support and executive functions
    Laurence Taconnat
    UMR CNRS 6234 Centre de Recherches sur la Cognition et l Apprentissage, Universite de Tours, Tours, France
    J Clin Exp Neuropsychol 32:719-27. 2010
    ..These findings support the view that the decrement in executive function due to depression may lead to impairment in organization when this mnemonic strategy has to be self-initiated...
  48. pmc Adult age differences and the role of cognitive resources in perceptual-motor skill acquisition: application of a multilevel negative exponential model
    Paolo Ghisletta
    Faculty of Psychology and Educational Sciences, University of Geneva, 4136 UniMail, Boulevard du Pont d Arve 40, 1211 Geneve 4, Switzerland
    J Gerontol B Psychol Sci Soc Sci 65:163-73. 2010
    ....
  49. pmc Decline and compensation in aging brain and cognition: promises and constraints. Preface
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychol Rev 19:411-4. 2009
    ..We also need to understand the sources of profound individual variability in aging trajectories, and to learn to tailor interventions to specific individual profiles of decline...
  50. pmc Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension
    S Burgmans
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuroimage 49:2083-93. 2010
    ..These findings indicate that of all examined measures, diffusion-based indices of white matter integrity may be the most sensitive indicators of global and regional declines and vascular damage in the aging brain...
  51. pmc BDNF Val66Met Polymorphism Influences Age Differences in Microstructure of the Corpus Callosum
    Kristen M Kennedy
    Center for Brain Health, School of Behavioral and Brain Sciences, The University of Texas at Dallas Dallas, TX, USA
    Front Hum Neurosci 3:19. 2009
    ..Those individuals with a genetic predisposition for decreased BDNF expression may not be able to fully benefit from BDNF-based plasticity and repair mechanisms...
  52. pmc Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk
    Kristen M Kennedy
    Center for Brain Health, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA
    Brain Res 1297:41-56. 2009
    ..Although the causal role of vascular risk in brain aging is unclear, the observed pattern of effects suggests that vascular risk may drive the expansion of age-related white matter damage from anterior to posterior regions...
  53. pmc Minute effects of sex on the aging brain: a multisample magnetic resonance imaging study of healthy aging and Alzheimer's disease
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    J Neurosci 29:8774-83. 2009
    ..Analyses of the AD sample showed no interactions between sex and age for any brain region. We conclude that sex has negligible effects on the age slope of brain volumes both in healthy participants and in AD...
  54. pmc Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 23:475-91. 2009
    ..The results indicate that age-related differences in perceptual priming and skill learning have dissociable cognitive and neural correlates...
  55. pmc Consistent neuroanatomical age-related volume differences across multiple samples
    Kristine B Walhovd
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
    Neurobiol Aging 32:916-32. 2011
    ..Healthy aging appears associated with more widespread and consistent age-related neuroanatomical volume differences than previously believed...
  56. pmc Effects of age, genes, and pulse pressure on executive functions in healthy adults
    Naftali Raz
    Institute of Gerontology, Wayne State University, 87 E Ferry St, Detroit, MI 48202, USA
    Neurobiol Aging 32:1124-37. 2011
    ..These findings suggest that in healthy adults, the effects of genetic risk factors significantly modulate the course of cognitive aging...
  57. pmc Increased sensitivity to effects of normal aging and Alzheimer's disease on cortical thickness by adjustment for local variability in gray/white contrast: a multi-sample MRI study
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neuroimage 47:1545-57. 2009
    ..In sum, the findings indicate that adjusting for contrast can increase the sensitivity of MR morphometry to variables of interest...
  58. ncbi Differential aging of the brain: patterns, cognitive correlates and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Neurosci Biobehav Rev 30:730-48. 2006
    ..Lastly, we speculate on several proposed mechanisms of differential brain aging, including neurotransmitter systems, stress and corticosteroids, microvascular changes, calcium homeostasis, and demyelination...

Research Grants30

  1. CARDIOVASCULAR DYNAMICS AND THEIR CONTROL
    John E Hall; Fiscal Year: 2013
    ..End of Abstract) ..
  2. IL-13 and IL-17 dynamics in the asthmatic airway
    Dean Sheppard; Fiscal Year: 2013
    ..RELEVANCE: Epithelial cells line the airways and play an important role in asthma. Micro-RNAs regulate gene expression. We will identify the nature, causes and consequences of changes in airway epithelial cell micro-RNAs in asthma. ..
  3. Emory Alzheimer's Disease Center
    Allan I Levey; Fiscal Year: 2013
    ..abstract_text> ..
  4. Alzheimer's Disease Research Center
    Thomas J Montine; Fiscal Year: 2013
    ..Montine;Project 2: Therapeutic Effects of Intra-Nasal Insulin Detemir, Dr. Suzanne Craft;Project 3: Modulation of A peptide accumulation and neuron damage in vivo with adult bone marrow transplants, Dr. C. Dirk Keene. ..
  5. Defining and Treating Written Language Disabilities
    VIRGINIA WISE BERNINGER; Fiscal Year: 2013
    ..The proposed multidisciplinary research has practical significance for improving diagnosis and providing more effective services which may lower such risks. ..
  6. HEALTHY AGING AND SENILE DEMENTIA
    John Morris; Fiscal Year: 2013
    ..Together, these projects and their supporting cores will focus on preclinical DAT in comparison with healthy brain aging and address the issue of detecting preclinical disease. ..
  7. EARLY EVENTS IN ALZHEIMER PATHOGENESIS
    SUE TILTON GRIFFIN; Fiscal Year: 2013
    ..The synergy between our aims, approaches, and measures will enable us to meet our goal of defining early cellular interactions toward development of rational interventions in AD. ..
  8. Inflammatory responses of vascular cells
    Paul L Fox; Fiscal Year: 2013
    ..abstract_text> ..
  9. Massachusetts Alzheimer's Disease Research Center
    Bradley T Hyman; Fiscal Year: 2013
    ..Going forward, the MADRC will continue to expand its clinical and neuropathological resources, its innovative training and scientific programs directed toward AD research. ..
  10. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..abstract_text> ..
  11. Arterial Aging, Brain Perfusion &Exercise: Impact on Brain Structure &Function.
    Rong Zhang; Fiscal Year: 2013
    ..Practically, the new findings are potentially important for developing new strategies to maintain cognitive vitality with age. ..
  12. ALZHEIMER DISEASE RESEARCH CENTER
    HELENA CHANG CHUI; Fiscal Year: 2013
    ..abstract_text> ..
  13. Alzheimer's Disease Research Center
    Douglas R Galasko; Fiscal Year: 2013
    ..It will provide an environment and core resources to enhance research, foster professional and community training, and coordinate interdisciplinary research. ..