VISUAL SCIENCES TRAINING PROGRAM

Summary

Principal Investigator: Eric Pearlman
Abstract: Form Approved Through 11/30/2010 PI: BRADY-KALNAY, SUSANN Council: 01/2010 [unreadable]'and Human Services 12155133 Ith Services 2T32EY007157-11 Dual: IRG: ZEY1 SRC(99) Do not exceed character length restriciims indicated. Received: 05/13/2009 1. TITLE OF PROJECT (Do not exceed 81 characters, including spaces and punctuation.) Visual Sciences Training Program 2. RESPONSE TO SPECIFIC REQUEST FOR APPLICATIONS OR PROGRAM ANNOUNCEMENT OR SOLICITATION D NO ^ YES (if "Yes," state number and title) Number: PA-08-226 Title: Kirschstein National Research Service Award Institutional Research Training Grants 3. PROGRAM DIRECTORyPRINCIPAL INVESTIGATOR New Investigator |^ No LJ Yes 3a. NAME (Last, first, middle) 3b. DEGREE(S) 3h. eRA Commons User Name Brady-Kalnay, Susann M. Ph.D. sbradykalnay 3c. POSITION TITLE 3d. MAILING ADDRESS (Street, city, state, zip code) Associate Professor Dept. of Molecular Biology and Microbiology 3e. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT Case Western Reserve University Dept. of Molecular Biology and Microbiology 10900 Euclid Avenue 3f. MAJOR SUBDIVISION Cleveland, OH 44106-4960 School of Medicine 3g. TELEPHONE AND FAX (Area code, number and extension) E-MAIL ADDRESS: TEL: 216-368-0330 FAX: 216-368-3055 susann.brady-kalnay@case.edu 4. HUMAN SUBJECTS RESEARCH 4a. Research Exempt If "Yes," Exemption No. IE No D Yes n No n Yes 4b. Federal-Wide Assurance No. 4c. Clinical Trial 4d. NIH-defined Phase III Clinical Trial lEl No D Yes 3 No n Yes 5. VERTEBRATE ANIMALS Q No S Yes 5a. Animal Welfare Assurance No. A3145-01 DATES OF PROPOSED PERIOD OF 7. COSTS REQUESTED FOR INITIAL 8. COSTS REQUESTED FOR PROPOSED SUPPORT (month, day. year-MM/DD/YY) BUDGET PERIOD PERIOD OF SUPPORT From Through 7a. Direct Costs (S) 7b. Total Costs (S) 8a. Direct Costs ($) 8b. Total Costs ($) 09/30/2010 09/29/15 $417,876 $438,382 $2,156,124 $2,259,998 9. APPLICANT ORGANIZATION 10. TYPE OF ORGANIZATION Name Case Western Reserve University Public: ->n Federal [unreadable] State [unreadable] Local Address g^^i^oQi ^f Medicine Private: ->H Private Nonprofit 10900 Euclid Avenue For-profit: -" CH General Q Small Business Cleveland, OH 44106-4960 I I Woman-owned dH Socially and Economically Disadvantaged 11. ENTITY IDENTIFICATION NUMBER 34-1018992 DUNS NO. 07-775-8407 Icong. District 11 12. ADMINISTRATIVE OFFICIAL TO BE NOTIFIED IF AWARD IS MADE 13. OFFICIAL SIGNING FOR APPLICANT ORGANIZATION Name Holly Lipkovich Name Robin Bissell Title Manager, Dept. Research Accouting &Budget Title Director, Research Accounting &Forecasting Address Qggg Western Reserve University Address Qggg Western Reserve University 10900 Euclid Avenue 10900 Euclid Avenue Cleveland, OH 44106 Cleveland, OH 44106 Tel: 216-368-4432 FAX: 216-368-0929 Tel: 216-368-4432 FAX: 216-368-0929 E-Mail: medres@case.edu E-Mail: medres@case.edu 14. APPLICANT ORGANIZATION CERTIFICATION AND ACCEPTANCE: I certify that SIGNATURE_OF OFFICIAL NAMED IN 13. the statements herein are true, complete and accurate to the best of my knowledge, and (In ink. "Per"'signaiuls not acceptable.) accept the obligation to comply with Public Health Services terms and conditions if a grant is awarded as a result of this application. I am aware that any false, fictitious, or fraudulent statements or claims may subject me to criminal, civil, or administrative penalties. PHS 398 (Rev. 11/07) Face Page Form Page 1 :;" Program Director/Principal Investigator (Last, First, Middle): Brady-Kalnay, SusanP M. PROJECT SUMMARY (See instructions): Twenty-three scientists in the Visual Sciences Research Center at Case Western Reserve University (CWRU) seek continued support for a Visual Sciences Training Program. The faculty comprise a multi- disciplinary vision sciences research community encompassing the Departments of Biomedical Engineering, Epidemiology &Biostatistics, Molecular Biology &Microbiology, Neurosciences, Ophthalmology &Visual Sciences, Pathology and Pharmacology. Expansion of capabilities and productivity in the field of vision research has led to its selection as a priority in strategic planning at CWRU. The momentum behind the expansion of the NEI Core grant-supported Visual Sciences Research Center has produced a dramatic increase in the number of vision scientists and extramural support for their research. This atmosphere affords an ideal training opportunity for vision scientists. The Visual Sciences Research Center and collaborative research of its participating faculty provides an overall framework for the Visual Sciences Training Program. In addition, as vision research has expanded at CWRU, there has been a natural evolution of five research/training groups that have distinct identities but also considerable overlap among participants. This Institutional Training Grant renewal application is organized around the five thematic (a) Retinal Development and Disease, (b) Phototransduction, (c) Aging and Diabetes in the Eye, (d) Ocular Inflammation and Infection, and (e) Translational Visual Sciences. Continued support is requested for six predoctoral student positions and two postdoctoral positions in all years. The demands of our program are such that only students of the highest potential are admitted. Students will receive training in department-specific, vision research theme-specific, and laboratory-based settings. Collectively, this approach will ensure that our trainees will be able to pose biologically and clinically relevant questions in visual science research without being restricted by either discipline or methodology. The training program is supported by the resources of the 23 vision scientists, 9 accessory faculty, the Core modules of the Visual Science Research Center, and the broader resources of Case Western Reserve University, University Hospitals of Cleveland and the VA Medical Center. RELEVANCE (See instructions): Twenty-three scientists in the Visual Sciences Research Center at CWRU seek continued support for a Visual Sciences Training Program. This Institutional Training Grant renewal application is organized around the five thematic (a) Retinal Development and Disease, (b) Phototransduction, (c) Aging and Diabetes in the Eye, (d) Ocular Inflammation and Infection, and (e) Translational Visual Sciences. Continued support is requested for six predoctoral student positions and two postdoctoral positions in all years. PROJECT/PERFORMANCE SITE(S) (if additional space is needed, use Project/Performance Site Format Page) Project/Performance Site Primary Location Organizational Name: Case Western Reserve University DUNS: 07-775-8407 street 1: 10900 Euclid Avenue street 2: School of Medicine City: Cleveland County: Cuyahoga state: OH Province: Country: USA Zip/Postal Code: 44106 Project/Performance Site Congressional Districts: 11 Additional Project/Performance Site Location Organizational Name: DUNS: street 1: street 2: City: County: state: Province: Country: Zip/Postal Code: Project/Performance Site Congressional Districts: PHS 398 (Rev. 11/07) Page 2 Form Page 2 Program Director/Principal Investigator (Last, First, Middle): Brady-Kalnay, Susann M. SENIOR/KEY PERSONNEL. See instructions. Use continuation pages as neededlo provide ttie required information in the format stiown below. Start witti Program Director(s)/Principal Investigator(s). List all ottier senior/key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Brady-Kalnay, Susann sbradykalnay Case Western Reserve PI Pearlman, Eric EPEARLMAN Case Western Reserve Associate Director VSTP Trainers listed in Table 2 OTHER SIGNIFICANT CONTRIBUTORS Name Organization Role on Project Human Embryonic Stem Cells ^ No [unreadable] Yes If the proposed project involves human embryonic stem cells, list below the registration number of the specific cell llne(s) from the following list: http://Stemcelis. nih.qov/research/reqistrv/. Use continuation pages as needed. If a specific line cannot be referenced at this time, include a statement that one from the Registry will be used. Cell Line PHS 398 (Rev. 11/07) Page 3 Form Page 2-continued Number the following pages consecutively throughout the application. Do not use suffixes such as 4a, 4b. Institutional Training TOO Substitute Page Program Director/Principal Investigator (Last, First, Middle): Brady-Kalnay, Susann M. Type the name of the program director/principal investigator at the top of each printed page and each continuation page. (For type specifications, see PHS 398 Instructions.) INSTITUTIONAL RESEARCH TRAINING INCLUDING RUTH L. KIRSCHSTEIN NATIONAL RESEARCH SERVICE AWARD TABLE OF CONTENTS (Substitute Page) Page Numbers Face Page (Form Page 1) 1 Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, and Human Embryonic Stem Cells {Form Page 2, Form Page 2-continued, and additional continuation page, if necessary) Table of Contents (tfiis Institutional Training Substitute Form Page 3) Detailed Budget for Initial Budget Period (Institutional Training Substitute Form Page 4) Budget for Entire Proposed Period of Support (Institutional Training Substitute Form Page 5) Biographical Sketch-Program Director/Principal Investigator (Not to exceed four pages) Resources 15 Research Training Program Plan 1. Introduction (Resubmission or Revision Application only) 2. Background 3. Program Plan a. Program Administration b. Program Faculty c. Proposed Training d. Training Program Evaluation e. Trainee Candidates 4. Recruitment and Retention Plan to Enhance Diversity 5. Plan for Instruction in the Responsible Conduct of Research 6. Progress Report (Renewal Applications Only) 7. Human Subjects 8. Vertebrate Animals 9. Select Agent Research 10. Literature Cited 11. Multiple PD Leadership Plan (if applicable) 12. Consortium/Contractual Arrangements 13. Participating Faculty Biosketches (not to exceed four pages each) 14. Data Tables 15. Letters of Support Checklist Appendix (Five identical CDs.) N/A [unreadable]\ 21 23 23 . (Items 2-5: not to exceed 25 pages, 26 ..excluding tables') <32 39 40 41 \. 45 46 69 69 N/A N/A N/A N/A 70 169 N/A 391 S CAphpeeckndifix i[unreadable]s included 'Font and margin requirements must conform to limits provided in PHS 398 Specific Instructions. PHS 398 (Rev. 11/07) Page 4 Institutional Training Substitute Form Page 3
Funding Period: 2000-09-30 - 2015-09-29
more information: NIH RePORT

Top Publications

  1. pmc Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite
    Luis Muniz-Feliciano
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS Pathog 9:e1003809. 2013
  2. pmc Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1
    Katherine E Trueblood
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Am J Physiol Cell Physiol 301:C1213-23. 2011
  3. pmc Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration
    Debarshi Mustafi
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    FASEB J 25:3157-76. 2011
  4. pmc Maternal-fetal transfer and metabolism of vitamin A and its precursor β-carotene in the developing tissues
    Elizabeth Spiegler
    Department of Food Sciences and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1821:88-98. 2012
  5. pmc Mammalian carotenoid-oxygenases: key players for carotenoid function and homeostasis
    Glenn P Lobo
    Case Western Reserve University, School of Medicine, Department of Pharmacology, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1821:78-87. 2012
  6. pmc Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1
    Casey Charvet
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 286:20413-22. 2011
  7. pmc Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology
    Debarshi Mustafi
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4965, USA
    J Neurosci Methods 198:70-6. 2011
  8. pmc Method for optical coherence elastography of the cornea
    Matthew R Ford
    Case Western Reserve University, Department of Biomedical Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Biomed Opt 16:016005. 2011
  9. pmc The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels
    Jose Andres C Portillo
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e14472. 2010
  10. pmc Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain
    Wei Li Liao
    Institute for Bioscience and Biotechnology Research, Rockville, Maryland 20850, USA
    J Proteome Res 10:241-8. 2011

Research Grants

  1. P30 - CORE GRANT FOR VISION RESEARCH
    Mahnaz Shahidi; Fiscal Year: 2013
  2. DETERMINANTS OF ROD AND CONE RESPONSE CHARACTERISTICS
    JAMES BRYANT HURLEY; Fiscal Year: 2013
  3. Core Support for Vision Research
    Michael E Goldberg; Fiscal Year: 2013
  4. RESEARCH TRAINING IN VISUAL SCIENCES
    Samuel M Wu; Fiscal Year: 2013
  5. Nanoparticle-based Photo-activator of Voltage-gated Sodium Channels
    David R Pepperberg; Fiscal Year: 2013
  6. MODEL-BASED IMAGE ENHANCEMENT FOR THE VISUALLY IMPAIRED
    Eli Peli; Fiscal Year: 2013
  7. Core Support for Vision Research at Indiana University
    Stephen A Burns; Fiscal Year: 2013
  8. CORE GRANT FOR VISION RESEARCH
    J Anthony Movshon; Fiscal Year: 2013
  9. Translational Vision Science Research at Oregon Health &Science University
    WILLIAM ROWLAND TAYLOR; Fiscal Year: 2013
  10. Watching Television and Movies with Low Vision
    RUSSELL LAURENCE WOODS; Fiscal Year: 2013

Detail Information

Publications63

  1. pmc Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite
    Luis Muniz-Feliciano
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS Pathog 9:e1003809. 2013
    ..gondii to maintain the non-fusogenic nature of the parasitophorous vacuole and suggest that EGF-MICs have a novel role in affecting signaling in host cells to promote parasite survival...
  2. pmc Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1
    Katherine E Trueblood
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Am J Physiol Cell Physiol 301:C1213-23. 2011
    ....
  3. pmc Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration
    Debarshi Mustafi
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    FASEB J 25:3157-76. 2011
    ..Overcoming the retinal phagocytosis defect could arrest the progressive degenerative component of this disease...
  4. pmc Maternal-fetal transfer and metabolism of vitamin A and its precursor β-carotene in the developing tissues
    Elizabeth Spiegler
    Department of Food Sciences and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1821:88-98. 2012
    ..The need for future research on the metabolism of these essential lipophilic nutrients during development is highlighted. This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism...
  5. pmc Mammalian carotenoid-oxygenases: key players for carotenoid function and homeostasis
    Glenn P Lobo
    Case Western Reserve University, School of Medicine, Department of Pharmacology, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1821:78-87. 2012
    ..This article is part of a Special Issue entitled Retinoid and Lipid Metabolism...
  6. pmc Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1
    Casey Charvet
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 286:20413-22. 2011
    ..The proteomic protocols developed in this study are generally applicable to characterization of lipid-derived oxidative protein modifications occurring in vivo, including proteins bound to membranes...
  7. pmc Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology
    Debarshi Mustafi
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4965, USA
    J Neurosci Methods 198:70-6. 2011
    ..Overall, this work presents a new method to study photoreceptor cells at high structural resolution that has a broad applicability to the visual neuroscience field...
  8. pmc Method for optical coherence elastography of the cornea
    Matthew R Ford
    Case Western Reserve University, Department of Biomedical Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Biomed Opt 16:016005. 2011
    ....
  9. pmc The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels
    Jose Andres C Portillo
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e14472. 2010
    ..In addition, they support that autophagy is a mechanism through which CD40-dependent immunity mediates in vivo protection and that the CD40-autophagic machinery is needed for host resistance despite IFN-γ...
  10. pmc Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain
    Wei Li Liao
    Institute for Bioscience and Biotechnology Research, Rockville, Maryland 20850, USA
    J Proteome Res 10:241-8. 2011
    ..The data obtained provide important insights into the mechanisms of cholesterol elimination from different neural tissues...
  11. pmc Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain
    Natalia Mast
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Invest Ophthalmol Vis Sci 52:594-603. 2011
    ..For comparison, they measured cholesterol oxidation products in two regions of the bovine and human brain and in the bovine liver and adrenal glands...
  12. pmc Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration
    L J Kopplin
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Genes Immun 11:609-21. 2010
    ..From these efforts, we report the identification of two novel protective factors for AMD and confirm the previously known associations at CFH, ARMS2 and C3...
  13. pmc Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain
    Natalia Mast
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:31783-95. 2010
    ..Co-complexes with tranylcypromine, thioperamide, and voriconazole represent the first structural characterization of the drug binding to a P450 enzyme...
  14. pmc Structural characterization of the rod cGMP phosphodiesterase 6
    Anna Goc
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    J Mol Biol 401:363-73. 2010
    ....
  15. pmc A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration
    Theru A Sivakumaran
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 6:e25598. 2011
    ..We conclude that causal variation in this region potentially encompasses both regulatory effects at single markers and copy number...
  16. pmc Spatial distribution of the pathways of cholesterol homeostasis in human retina
    Wenchao Zheng
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 7:e37926. 2012
    ..Challenges in studies of the retina include its complex multicellular and multilayered structure; unique cell types and functions; and specific physico-chemical environment...
  17. pmc Inflammatory priming predisposes mice to age-related retinal degeneration
    Debarshi Mustafi
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA
    J Clin Invest 122:2989-3001. 2012
    ....
  18. pmc Antagonism of CD11b with neutrophil inhibitory factor (NIF) inhibits vascular lesions in diabetic retinopathy
    Alexander A Veenstra
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 8:e78405. 2013
    ..We conclude that antagonism of CD11b (integrin αmβ2) by NIF is sufficient to inhibit early stages of diabetic retinopathy, while not compromising the basic immune response. ..
  19. pmc Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light
    Casey D Charvet
    From the Departments of Ophthalmology and Visual Sciences
    J Biol Chem 288:29267-80. 2013
    ..Our study demonstrates that preventing the damage to biomolecules by lipid peroxidation products, a novel concept in vision research, is a viable strategy to combat oxidative stress in the retina. ..
  20. pmc Photoreceptor phagocytosis is mediated by phosphoinositide signaling
    Debarshi Mustafi
    1Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4965, USA
    FASEB J 27:4585-95. 2013
    ..Our phenotypic and genotypic characterization reveals a complex global landscape of overlapping and temporally controlled networks driving the essential circadian process in the eye...
  21. pmc Atomic force microscopy: a multifaceted tool to study membrane proteins and their interactions with ligands
    Allison M Whited
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1838:56-68. 2014
    ..This article is part of a Special Issue entitled: Structural and biophysical characterization of membrane protein-ligand binding. ..
  22. pmc Evolutionarily conserved long intergenic non-coding RNAs in the eye
    Debarshi Mustafi
    Department of Pharmacology, Cleveland Clinic, Cleveland, OH 44106 4965, USA
    Hum Mol Genet 22:2992-3002. 2013
    ..This combined approach identified several lincRNAs that could be critical for retinal and visual maintenance in adults. ..
  23. pmc CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins
    Jennifer Van Grol
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Infect Immun 81:2002-11. 2013
    ..gondii were dependent on the autophagy proteins Beclin 1 and Atg7. Together, these studies revealed that CD40 induces toxoplasmacidal activity in various nonhematopoietic cells dependent on proteins of the autophagy machinery...
  24. pmc Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1
    Casey D Charvet
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Lipid Res 54:1421-9. 2013
    ....
  25. pmc Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization
    Ning Zhang
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44160, USA
    J Clin Invest 123:121-37. 2013
    ..Additionally, these results suggest that patients heterozygous for the E150K mutation should be periodically reevaluated for delayed-onset retinal degeneration...
  26. pmc Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1
    Mausita Karmakar
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 189:4231-5. 2012
    ..Together, these results demonstrate that during P. aeruginosa infection, neutrophils are the primary source of mature IL-1β and that IL-1β processing is dependent on serine proteases and not NLRC4 or caspase-1...
  27. pmc Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice
    Guangyuan Li
    Case Western Reserve University and Case Medical Center, Cleveland, Ohio, USA
    Diabetes 61:3294-303. 2012
    ..iNOS and PARP1 are known to play a role in inflammatory processes, and we conclude that proinflammatory processes within marrow-derived cells play a central role in the development of diabetes complications in the retina and nerve...
  28. pmc A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids
    Song Qi Gao
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Invest Ophthalmol Vis Sci 53:6314-23. 2012
    ....
  29. pmc Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis
    Saida Omarova
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Invest 122:3012-23. 2012
    ....
  30. pmc A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase mu
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    Neoplasia 12:305-16. 2010
    ..Such a tool has clear translational applications and may lead to improved surgical resections and prognosis for patients with this devastating disease...
  31. pmc Membrane-binding and enzymatic properties of RPE65
    Philip D Kiser
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland OH 44106 4965, USA
    Prog Retin Eye Res 29:428-42. 2010
    ....
  32. pmc Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin
    Samantha A Oblander
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Mol Cell Neurosci 44:78-93. 2010
    ..In summary, distinct PTPmicro-associated signaling proteins are required to promote neurite outgrowth on cadherins...
  33. pmc Molecular mechanisms and clinical implications of reversible protein S-glutathionylation
    John J Mieyal
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 10:1941-88. 2008
    ..Examples involving changes in S-glutathionylation of specific proteins are discussed in the context of diabetes, cardiovascular and lung diseases, cancer, and neurodegenerative diseases...
  34. pmc Impact of retinal disease-associated RPE65 mutations on retinoid isomerization
    Grzegorz Bereta
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Biochemistry 47:9856-65. 2008
    ....
  35. pmc Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases
    Melissa D Shelton
    Department of Pharmacology, School of Medicine, Case Western Reserve University, and Louis Stokes Cleveland Veterans Affairs Medical Research Center, Cleveland, Ohio 44106 4965, USA
    Mol Cells 25:332-46. 2008
    ....
  36. pmc Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina
    Marcin Golczak
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 283:9543-54. 2008
    ..Finally, we provide evidence for a crucial role of lecithin: retinol acyltransferase activity in mediating tissue specific absorption and long lasting therapeutic effects of retinoid-based visual cycle inhibitors...
  37. ncbi Activating transcription factor 3 induction in sympathetic neurons after axotomy: response to decreased neurotrophin availability
    H Hyatt Sachs
    Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4975, USA
    Neuroscience 150:887-97. 2007
    ....
  38. pmc Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes
    Paul S H Park
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Annu Rev Pharmacol Toxicol 48:107-41. 2008
    ..More recent studies indicate a need to move beyond these classical paradigms and to consider additional aspects of the molecular character of GPCRs, such as the oligomerization and dynamics of the receptor...
  39. pmc Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions
    Philip D Kiser
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:457-61. 2007
    ..In general, the structure is similar to the previously determined wild-type GroEL crystal structure with some differences in regard to temperature-factor distribution...
  40. ncbi Methylglyoxal inhibits glycation-mediated loss in chaperone function and synthesis of pentosidine in alpha-crystallin
    Shivaprakash Puttaiah
    Department of Ophthalmology, Case Western Reserve University, Cleveland, OH, USA
    Exp Eye Res 84:914-21. 2007
    ..Together, these data suggest that in the aging lens, MGO inhibits glycation-mediated pentosidine synthesis and the loss of chaperone function of alpha-crystallin...
  41. ncbi Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy
    Melissa D Shelton
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:12467-74. 2007
    ..Thus, GRx may represent a novel therapeutic target to inhibit diabetic retinopathy...
  42. pmc E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner
    Samantha A Oblander
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4960, USA
    Mol Cell Neurosci 34:481-92. 2007
    ..Taken together, these findings demonstrate that E-cadherin is an important adhesion molecule for chick RGC neurite outgrowth and suggest that PTPmu expression and catalytic activity are required for outgrowth on an E-cadherin substrate...
  43. pmc Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model
    Xingjun Fan
    Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106 7288, USA
    Proc Natl Acad Sci U S A 103:16912-7. 2006
    ..The hSVCT2 mouse is expected to facilitate the search for drugs that inhibit damage by vitamin C oxidation products...
  44. ncbi Reduction in nerve growth factor availability leads to a conditioning lesion-like effect in sympathetic neurons
    S E Shoemaker
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4975, USA
    J Neurobiol 66:1322-37. 2006
    ..While NGF administration did not prevent the conditioning lesion effect, this may be due to the markedly decreased ability of sympathetic neurons to accumulate the growth factor after axotomy...
  45. ncbi Relative suppression of the sodium-dependent Vitamin C transport in mouse versus human lens epithelial cells
    Mark E Obrenovich
    Department of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Mol Cell Biochem 293:53-62. 2006
    ..Acta Ophthalmol Scand 83: 228-223, 2005). Elucidation of the mechanism by which SCVT2 activity is suppressed in mouse lens may help unravel a major question of evolutionary significance for night vision in nocturnal animals...
  46. pmc Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene
    Bo Chang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 17:3929-41. 2008
    ..Analysis of a cohort of patients with age-related macular degeneration (AMD) wherein the susceptibility locus maps to chromosome 12q, a region bearing the human ortholog to MDM1, did not reveal association between human MDM1 and AMD...
  47. ncbi Differential regulation of high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation in Müller cells by IL-1beta and IL-6
    E CHEPCHUMBA K YEGO
    Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    Invest Ophthalmol Vis Sci 50:1920-8. 2009
    ....
  48. pmc Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells
    Melissa D Shelton
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4965, USA
    J Biol Chem 284:4760-6. 2009
    ..Hence Grx-mediated activation of IKK via deglutathionylation may play a central role in diabetic complications in vivo where Grx1 is increased...
  49. pmc The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision
    Johannes von Lintig
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Trends Biochem Sci 35:400-10. 2010
    ..These 'ancestral footprints' in animal genomes bear witness to the common origin of the chemistry of vision, and will further stimulate research across evolutionary boundaries...
  50. pmc Importance of membrane structural integrity for RPE65 retinoid isomerization activity
    Marcin Golczak
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:9667-82. 2010
    ..Thus, our results indicate that the enzymatic activity of native RPE65 strongly depends on its membrane binding and phospholipid environment...
  51. pmc siah-1 Protein is necessary for high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation and cell death in Muller cells
    E CHEPCHUMBA K YEGO
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 285:3181-90. 2010
    ..Therefore, inhibition of GAPDH nuclear translocation and accumulation by targeting siah-1 promotes Müller cell survival under hyperglycemic conditions...
  52. pmc Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 12:1339-53. 2010
    ..Taken together, these data indicate diminution of Grx1 in elderly animals contributes to increased apoptotic susceptibility via regulation of NFkappaB function...
  53. pmc A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1
    Grzegorz Bereta
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:1899-908. 2010
    ..However, evidence is presented that autophosphorylation does not regulate GC1 activity, in contrast to phosphorylation of other members of this cyclase family...
  54. pmc Use of thallium to identify monovalent cation binding sites in GroEL
    Philip D Kiser
    Case Western Reserve University, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:967-71. 2009
    ..These findings also demonstrate the general usefulness of Tl(+) for the identification of monovalent cation-binding sites in protein crystal structures, even when the quality and resolution of the diffraction data are relatively low...
  55. pmc Crystal structure of native RPE65, the retinoid isomerase of the visual cycle
    Philip D Kiser
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Proc Natl Acad Sci U S A 106:17325-30. 2009
    ....
  56. pmc Structural waters define a functional channel mediating activation of the GPCR, rhodopsin
    Thomas E Angel
    Department of Pharmacology, Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Proc Natl Acad Sci U S A 106:14367-72. 2009
    ..These results suggest both a possible general mechanism for water-dependent communication in family A GPCRs based on structural conservation, and a strategy for probing membrane protein structure...
  57. pmc Structure of cone photoreceptors
    Debarshi Mustafi
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Prog Retin Eye Res 28:289-302. 2009
    ....
  58. pmc Using the NAFX to measure the effectiveness over time of gene therapy in canine LCA
    Jonathan B Jacobs
    Daroff Dell Osso Ocular Motility Laboratory, Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Invest Ophthalmol Vis Sci 50:4685-92. 2009
    ....
  59. pmc Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors
    Thomas E Angel
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Proc Natl Acad Sci U S A 106:8555-60. 2009
    ....
  60. pmc Chemokine receptors and other G protein-coupled receptors
    David T Lodowski
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Curr Opin HIV AIDS 4:88-95. 2009
    ..CXCR4 and CCR5 are utilized as co-receptors during HIV viral entry and, therefore, crystal structures of GPCRs aid in the understanding of their function in viral entry...
  61. pmc Comparative analysis of GPCR crystal structures
    David T Lodowski
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Photochem Photobiol 85:425-30. 2009
    ..In this review we summarize recent progress on the structure and activation of rhodopsin in the context of other GPCR structures...
  62. ncbi Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals
    David Salom
    Novasite Pharmaceuticals, Inc, San Diego, CA 92121, USA
    J Struct Biol 156:497-504. 2006
    ..Importantly, these new crystals are stable upon photoactivation and the preliminary X-ray diffraction analysis of both photoactivated and ground state rhodopsin crystals are also reported...

Research Grants56

  1. P30 - CORE GRANT FOR VISION RESEARCH
    Mahnaz Shahidi; Fiscal Year: 2013
    ....
  2. DETERMINANTS OF ROD AND CONE RESPONSE CHARACTERISTICS
    JAMES BRYANT HURLEY; Fiscal Year: 2013
    ..Knowledge of how energy is produced and distributed is of fundamental importance for understanding how photoreceptors function and remain viable. ..
  3. Core Support for Vision Research
    Michael E Goldberg; Fiscal Year: 2013
    ..This core will also facilitate collaboration among members of the Columbia vision research community, and encourage scientists not currently engaged in vision research to use their expertise to solve problems related to vision. ..
  4. RESEARCH TRAINING IN VISUAL SCIENCES
    Samuel M Wu; Fiscal Year: 2013
    ..Our goal is to produce outstanding vision researchers to face the scientific and medical challenges in the 21st century. ..
  5. Nanoparticle-based Photo-activator of Voltage-gated Sodium Channels
    David R Pepperberg; Fiscal Year: 2013
    ..H. Kent, PhD (Depts. of Chemistry, Biochemistry and Molecular Biology, Univ. of Chicago);and Karol S. Bruzik, PhD (Dept. of Medicinal Chemistry and Pharmacognosy, UIC). ..
  6. MODEL-BASED IMAGE ENHANCEMENT FOR THE VISUALLY IMPAIRED
    Eli Peli; Fiscal Year: 2013
    ..We will continue our psychophysical studies, in an effort to understand the adaptations and changes that affect patients who lose their central retina. ..
  7. Core Support for Vision Research at Indiana University
    Stephen A Burns; Fiscal Year: 2013
    ..The local research environment has expanded to include seven new active laboratories during the past eight years and at least three more are anticipated in the next three years. ..
  8. CORE GRANT FOR VISION RESEARCH
    J Anthony Movshon; Fiscal Year: 2013
    ....
  9. Translational Vision Science Research at Oregon Health &Science University
    WILLIAM ROWLAND TAYLOR; Fiscal Year: 2013
    ..OHSU is a setting where rigorous training in basic and clinical research through this T32 program will provide a generation of young researchers with the tools to optimize translational vision research. ..
  10. Watching Television and Movies with Low Vision
    RUSSELL LAURENCE WOODS; Fiscal Year: 2013
    ..abstract_text> ..
  11. Blur, Accommodation, and Vision
    Martin S Banks; Fiscal Year: 2013
    ..A better understanding will aid the design of stereo displays and the content shown on such displays. ..
  12. TRAINING PROGRAM IN VISION SCIENCE
    DENNIS MICHAEL LEVI; Fiscal Year: 2013
    ..The training is augmented by the extensive resources of the Berkeley campus and the technical support provided to the Group in Vision Science in an NEI Core Grant. ..
  13. VISION RESEARCH CORE GRANT
    John S Werner; Fiscal Year: 2013
    ....
  14. VISION RESEARCH CORE
    William W Hauswirth; Fiscal Year: 2013
    ..Each module offers state-of-the art instruments, services and advice, and continues to evolve to best meet the changing needs of its users in this rapidly developing era of ocular research. ..
  15. Berkeley Clinical Scientist Development Program
    Kenneth A Polse; Fiscal Year: 2013
    ..Consequently, the number of well-trained clinician scientists available to fill these positions has seriously declined. ..
  16. VISION SCIENCE RESEARCH CENTER
    Steven J Pittler; Fiscal Year: 2013
    ..A part time histological technician provides consultation for experimental design, technical expertise, and training of laboratory personnel. ..
  17. Michigan Vision Clinician Scientist Development Program
    Paul P Lee; Fiscal Year: 2013
    ....
  18. TRAINING PROGRAM IN VISION SCIENCE
    John S Werner; Fiscal Year: 2013
    ..All trainees will be engaged in vision science research that will be presented at national meetings and submitted to peer-reviewed journals. ..
  19. CORE GRANT FOR VISION RESEARCH
    Robert L Hendricks; Fiscal Year: 2013
    ....
  20. CORE GRANT FOR VISION RESEARCH
    Stephen C Massey; Fiscal Year: 2013
    ..With the continued support of the Vision Core Grant, a further period of growth and innovative research may be expected for the Vision Research Consortium. ..
  21. Identification and Characterization of the Genetic Basis of PPCD
    ANTHONY JOHN ALDAVE; Fiscal Year: 2013
    ....
  22. Adaptive Evolution of Color Vision
    Shozo Yokoyama; Fiscal Year: 2013
    ..Hence, the results obtained from our mutagenesis experiments and chemical structural computations of visual pigments together provide the fundamental information on the genetic bases of color vision defects and ocular diseases. ..
  23. Jules Stein Eye Institute Core Grant for Vision Research
    Wayne L Hubbell; Fiscal Year: 2013
    ..Support in the form of the Core grant is requested to maintain these Modules through instrument service contracts, and to provide necessary personnel support to assist and train users and provide routine maintenance. ..
  24. Regulation of Ocular Neural Crest and its Implications in Congenital Eye Diseases
    BRENDA LYNN BOHNSACK; Fiscal Year: 2013
    ..In particular, I will benefit from thoughtful, "hands-on" mentoring by experienced scientists and clinicians who are deeply committed to my success. ..
  25. Evolution of Avian Photopigments: From Sequences to Color Vision
    NATASHA IVONNE BLOCH; Fiscal Year: 2013
    ..Here, "natural experiments" provided by evolution, give us the opportunity to study the mechanisms of spectral tuning in visual pigments. ..
  26. RESEARCH TRAINING IN VISION SCIENCE
    W Clay Smith; Fiscal Year: 2013
    ..These new scientists are expected to generate discoveries in the underlying mechanisms of vision and associated pathologies, and to help develop treatments for these diseases..
  27. Corneal Wound Healing, Ocular Optics, and Endothelial Keratoplasty
    HOLLY BUTLER HINDMAN; Fiscal Year: 2013
    ....
  28. Training Grant in Vision Science
    David C Knill; Fiscal Year: 2013
    ..abstract_text> ..
  29. Short-term Training Students in Health Professional Schools
    Kenneth Joseph Ciuffreda; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The program is intended to train optometry students in clinical research and to encourage them to seek a career involving clinical vision science and optometric research. ..
  30. The Old Westbury Neuroscience Inernational Program
    Fernando Emilio Nieto-Fernandez; Fiscal Year: 2013
    ..Attaining this goal will also help affect a reduction in the health disparities gap. ..
  31. Proteomic Biomarkers for AMD
    John W Crabb; Fiscal Year: 2013
    ..Other outstanding resources include the experience of the translational investigative team, and a world-class vision research environment. The overall impact will be high as effective biomarkers will transform AMD patient management. ..
  32. P-30 Core Grant for Vision Research
    Janey L Wiggs; Fiscal Year: 2013
    ....
  33. SHORT TERM TRAINING FOR OPTOMETRY STUDENTS
    CHRISTINE FRANCES WILDSOET; Fiscal Year: 2013
    ..The long term goal is to encourage clinicians to continue research training/involvement after completion of their professional training. ..
  34. SHORT TERM TRAINING IN HEALTH PROFESSIONAL SCHOOLS
    Laura J Frishman; Fiscal Year: 2013
    ....
  35. Visual Science Training Grant
    Z Jimmy Zhou; Fiscal Year: 2013
    ..PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
  36. Short-Term Research Training for Optometry Students
    T Rowan Candy; Fiscal Year: 2013
    ....
  37. CORE GRANT IN VISION RESEARCH
    Jeffrey D Schall; Fiscal Year: 2013
    ..The high level of performance of VVRC investigators, which depends on renewed Core grant support, synergizes with campus-wide initiatives in biomedical research and training at Vanderbilt. ..
  38. CORE GRANT FOR VISION RESEARCH
    Steven Bassnett; Fiscal Year: 2013
    ..Provision of these support services and resources will greatly enhance the research capabilities of investigators at Washington University and will facilitate collaboration among new and established vision scientists. ..
  39. Harvard-Vision Clinical Scientist Development Program
    Reza Dana; Fiscal Year: 2013
    ..Our aim is to build on our progress to date, and continue our training program for an additional 5 years. ..
  40. PENN Vision Clinical Scientist Program
    Maureen G Maguire; Fiscal Year: 2013
    ..Upon completion of the program, scholars are well-prepared to perform productive and successful independent research. ..
  41. Continuously Decoding Visual Perception and Working Memory
    Michael S Pratte; Fiscal Year: 2013
    ..abstract_text> ..
  42. Visual System Development Gordon Research Conference
    Monica L Vetter; Fiscal Year: 2013
    ..abstract_text> ..
  43. PERCEPTUAL ORGANIZATION OF TWO DIMENSIONAL PATTERNS
    Wilson S Geisler; Fiscal Year: 2013
    ..Many of the proposed studies will also be the first to measure performance in these fundamental tasks using natural stimuli. Promising pilot data has been obtained in many of the proposed studies. ..
  44. Control of Attention by Working Memory
    Steven J Luck; Fiscal Year: 2013
    ....