Anaplasma marginale str. St. Maries

Summary

Alias: Anaplasma marginale 'St. Maries', Anaplasma marginale strain St. Maries

Top Publications

  1. pmc The twin-arginine translocation pathway in α-proteobacteria is functionally preserved irrespective of genomic and regulatory divergence
    Pablo A Nuñez
    Instituto de Biotecnologia, Instituto Nacional de Tecnologia Agropecuaria, CICVyA INTA, Buenos Aires, Argentina
    PLoS ONE 7:e33605. 2012
  2. ncbi Demonstration of Anaplasma (Ehrlichia) platys inclusions in peripheral blood platelets of a dog in Japan
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Parasitol 110:145-52. 2002
  3. pmc Experimental transmission of bovine anaplasmosis (caused by Anaplasma marginale) by means of Dermacentor variabilis and D. andersoni (Ixodidae) collected in western Canada
    Murray W Lankester
    Canadian Food Inspection Agency CFIA, Saskatoon Laboratory, Centre for Food borne and Animal Parasitology, 116 Veterinary Road, Saskatoon, Saskatchewan S7N 2R3
    Can J Vet Res 71:271-7. 2007
  4. pmc Differential expression and sequence conservation of the Anaplasma marginale msp2 gene superfamily outer membrane proteins
    Susan M Noh
    Program in Vector borne Diseas, Department of Microbiology and Pathology, Washington State University, Pullman, WA 99164 6630, USA
    Infect Immun 74:3471-9. 2006
  5. ncbi Evidence of tick-borne organisms in mule deer (Odocoileus hemionus) from the western United States
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    Vector Borne Zoonotic Dis 5:351-62. 2005
  6. ncbi Serologic and molecular characterization of Anaplasma species infection in farm animals and ticks from Sicily
    Jose De La Fuente
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 250 McElory Hall, Stillwater, OK 74078, USA
    Vet Parasitol 133:357-62. 2005
  7. ncbi Anaplasma infection in free-ranging Iberian red deer in the region of Castilla-La Mancha, Spain
    Jose De La Fuente
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13005 Ciudad Real, Spain
    Vet Microbiol 100:163-73. 2004
  8. ncbi Genetic diversity and molecular phylogeny of Anaplasma marginale isolates from Minas Gerais, Brazil
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA
    Vet Parasitol 121:307-16. 2004
  9. ncbi A novel antigen from Anaplasma marginale: characterization, expression and preliminary evaluation of the recombinant protein
    Michelle Hope
    Cooperative Research Center for Vaccine Technology and CSIRO Livestock Industries, Queensland Biosciences Precinct, 306 Carmody Road, QLD 4067, St Lucia, Australia
    Vaccine 22:407-15. 2004
  10. pmc Characterization of Anaplasma marginale isolated from North American bison
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Stillwater, Oklahoma 74078, USA
    Appl Environ Microbiol 69:5001-5. 2003

Research Grants

Patents

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
  2. Plants with increased yield
  3. Plants with increased yield
  4. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
  5. Process for the production of a fine chemical
  6. Process for the production of lutein
  7. Plants with increased yield (nue)
  8. Process for the production of fine chemicals
  9. Process for the control of production of fine chemicals
  10. Proteins associated with abiotic stress response and homologs

Scientific Experts

  • Jose De La Fuente
  • Guy Palmer
  • Hisashi Inokuma
  • WENDY CATHERINE BROWN
  • Michael V Bowie
  • Michael J Yabsley
  • Susan M Noh
  • Ala Lew-Tabor
  • Michelle Hope
  • A F Barbet
  • PATRICK F MEEUS
  • Pablo A Nuñez
  • Murray W Lankester
  • Ala E Lew
  • Anne Véronique Taillardat-Bisch
  • F D Von Loewenich
  • J S Dumler
  • Marcelo Soria
  • Marisa D Farber
  • M Camacho-Nuez
  • J S Chae
  • Neil C Chilton
  • Alvin A Gajadhar
  • W Brad Scandrett
  • Elizabeth J Golsteyn-Thomas
  • C P Kolbert
  • M Rollinghoff
  • D Theo de Waal
  • Catherine M Minchin
  • C Bogdan
  • Didier Raoult
  • G Stumpf
  • Varda Shkap
  • Kevin R Gale
  • Michel Drancourt
  • B U Baumgarten
  • G Eid
  • T C McGuire
  • J E Foley
  • J E Madigan
  • M De Lourdes Munoz
  • C E Suarez
  • J Adams-Stich
  • D H Persing
  • S R Telford
  • T F McElwain
  • P D Mitchell
  • E K Hofmeister
  • E S Bruinsma
  • R B Tompkins
  • A S Abdulkarim
  • D M French
  • A M Lundgren
  • S M Oberle
  • J M Peters
  • W K Jorgensen
  • D R Allred
  • B P Dalrymple
  • S R Leib
  • T M Harkins

Detail Information

Publications32

  1. pmc The twin-arginine translocation pathway in α-proteobacteria is functionally preserved irrespective of genomic and regulatory divergence
    Pablo A Nuñez
    Instituto de Biotecnologia, Instituto Nacional de Tecnologia Agropecuaria, CICVyA INTA, Buenos Aires, Argentina
    PLoS ONE 7:e33605. 2012
    ..In addition, the predicted substrates might be the evidence of role of the Tat translocation system in the transition process from a free-living to a parasitic lifestyle in these α-proteobacteria...
  2. ncbi Demonstration of Anaplasma (Ehrlichia) platys inclusions in peripheral blood platelets of a dog in Japan
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Vet Parasitol 110:145-52. 2002
    ..The sequence analysis of the 16S rRNA, citrate synthase and heat shock protein genes of DNA from the infected platelets confirmed that the inclusions were A. platys. This is the first detection of A. platys inclusions in dogs in Japan...
  3. pmc Experimental transmission of bovine anaplasmosis (caused by Anaplasma marginale) by means of Dermacentor variabilis and D. andersoni (Ixodidae) collected in western Canada
    Murray W Lankester
    Canadian Food Inspection Agency CFIA, Saskatoon Laboratory, Centre for Food borne and Animal Parasitology, 116 Veterinary Road, Saskatoon, Saskatchewan S7N 2R3
    Can J Vet Res 71:271-7. 2007
    ..Potential barriers, including climate, must be considered in developing strategies to prevent A. marginale from becoming established in anaplasmosis-free regions...
  4. pmc Differential expression and sequence conservation of the Anaplasma marginale msp2 gene superfamily outer membrane proteins
    Susan M Noh
    Program in Vector borne Diseas, Department of Microbiology and Pathology, Washington State University, Pullman, WA 99164 6630, USA
    Infect Immun 74:3471-9. 2006
    ..Maries strain and Florida strain genomes...
  5. ncbi Evidence of tick-borne organisms in mule deer (Odocoileus hemionus) from the western United States
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    Vector Borne Zoonotic Dis 5:351-62. 2005
    ..Together, these data suggest that MD in northern Arizona and eastern California are exposed to several pathogens of human and veterinary importance...
  6. ncbi Serologic and molecular characterization of Anaplasma species infection in farm animals and ticks from Sicily
    Jose De La Fuente
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 250 McElory Hall, Stillwater, OK 74078, USA
    Vet Parasitol 133:357-62. 2005
    ..Definition of the diversity of Anaplasma spp. in Sicily reported, herein is fundamental to development of control strategies for A. marginale, A. ovis and A. phagocytophilum in Sicily...
  7. ncbi Anaplasma infection in free-ranging Iberian red deer in the region of Castilla-La Mancha, Spain
    Jose De La Fuente
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13005 Ciudad Real, Spain
    Vet Microbiol 100:163-73. 2004
    ..marginatum and Rhipicephalus bursa were identified as potential biological vectors for A. marginale in this region and may effect transmission of A. marginale between deer and cattle populations...
  8. ncbi Genetic diversity and molecular phylogeny of Anaplasma marginale isolates from Minas Gerais, Brazil
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA
    Vet Parasitol 121:307-16. 2004
    ..marginale isolates, while MSP1a was found not to be a useful marker for phylogeographic characterization of A. marginale isolates...
  9. ncbi A novel antigen from Anaplasma marginale: characterization, expression and preliminary evaluation of the recombinant protein
    Michelle Hope
    Cooperative Research Center for Vaccine Technology and CSIRO Livestock Industries, Queensland Biosciences Precinct, 306 Carmody Road, QLD 4067, St Lucia, Australia
    Vaccine 22:407-15. 2004
    ..Preliminary data suggests a good correlation between the induction of an IgG2 response and protection...
  10. pmc Characterization of Anaplasma marginale isolated from North American bison
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Stillwater, Oklahoma 74078, USA
    Appl Environ Microbiol 69:5001-5. 2003
    ..marginale bison isolate for cattle. The results of this study showed that these A. marginale isolates obtained from bison were similar to ones from naturally infected cattle...
  11. ncbi A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic anaplasma phagocytophilum (HGE agent) in Germany
    F D Von Loewenich
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3 5, 91054, Erlangen, Germany
    Eur J Clin Microbiol Infect Dis 22:303-5. 2003
    ..Thus, the current lack of clinical cases of HGE in Germany is unlikely to result from the absence of pathogenic granulocytic ehrlichiae strains in German ticks...
  12. ncbi RNA polymerase beta-subunit-based phylogeny of Ehrlichia spp., Anaplasma spp., Neorickettsia spp. and Wolbachia pipientis
    Anne Véronique Taillardat-Bisch
    Unite des Rickettsies, CNRS UPRES A 6020, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille 5, France
    Int J Syst Evol Microbiol 53:455-8. 2003
    ..The rpoB nucleotide sequences were more variable than the 16S rRNA gene and groESL sequences at the species level...
  13. pmc Anaplasma marginale msp1alpha genotypes evolved under positive selection pressure but are not markers for geographic isolates
    Jose De La Fuente
    Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, Oklahoma 74708, USA
    J Clin Microbiol 41:1609-16. 2003
    ..marginale within Oklahoma could be explained by cattle movement and the maintenance of different genotypes by independent transmission events...
  14. ncbi The hypervariable region of Anaplasma marginale major surface protein 2 (MSP2) contains multiple immunodominant CD4+ T lymphocyte epitopes that elicit variant-specific proliferative and IFN-gamma responses in MSP2 vaccinates
    Wendy C Brown
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    J Immunol 170:3790-8. 2003
    ..Antigenic variation in MSP2 Th cell and B cell epitopes may contribute to immune evasion that allows long-term persistence of A. marginale in the mammalian reservoir...
  15. ncbi Conservation of a gene conversion mechanism in two distantly related paralogues of Anaplasma marginale
    Patrick F M Meeus
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32611 0880, USA
    Mol Microbiol 47:633-43. 2003
    ..A. marginale thus maintains two large, separate systems within its small genome to generate antigenic variation of its surface proteins, while analogous structural elements indicate a common mechanism...
  16. ncbi Phylogenetic analysis of the erythrocytic Anaplasma species based on 16S rDNA and GroEL (HSP60) sequences of A. marginale, A. centrale, and A. ovis and the specific detection of A. centrale vaccine strain
    Ala E Lew
    Department of Primary Industries, Agency for Food and Fibre Sciences, c o Animal Research Institute, 665 Fairfield Rd, Locked Mail Bag No 4, Yeerongpilly, Moorooka, Queensland 4105, Australia
    Vet Microbiol 92:145-60. 2003
    ..centrale vaccine (Theiler, 1911) specifically. This study confirms the suitability of 16S rDNA sequences to define genera and demonstrates the usefulness of GroEL sequences for defining species of erythrocytic Anaplasma...
  17. ncbi Sequence of a putative glutathione synthetase II gene and flanking regions from Anaplasma centrale
    J M Peters
    Commonwealth Scientific and Industrial Research Organisation, Division of Tropical Animal Production, Indooroopilly, QLD, Australia
    Biochem Biophys Res Commun 182:1040-6. 1992
    ..3.2.4). The predicted partial amino acid sequence is 33% identical to the amino acid sequence of the protein encoded by the E. coli ddl gene...
  18. pmc Determination of the nucleotide sequences of heat shock operon groESL and the citrate synthase gene (gltA) of Anaplasma (Ehrlichia) platys for phylogenetic and diagnostic studies
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 753 8515 Yamaguchi, Japan
    Clin Diagn Lab Immunol 9:1132-6. 2002
    ..The topology of the groEL- and gltA-based phylogenetic tree was similar to that derived from 16S rRNA gene analyses with distances. Both groESL- and gltA-based PCRs specific to A. platys were also developed based upon the alignment data...
  19. ncbi Phylogeography of New World isolates of Anaplasma marginale based on major surface protein sequences
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA
    Vet Microbiol 88:275-85. 2002
    ..marginale isolates. In contrast MSP1a sequences appeared to be rapidly evolving and these sequences may provide phylogeographic information only when numerous isolate MSP1a sequences are analyzed from a geographic area...
  20. pmc Infection of tick cells and bovine erythrocytes with one genotype of the intracellular ehrlichia Anaplasma marginale excludes infection with other genotypes
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Clin Diagn Lab Immunol 9:658-68. 2002
    ..marginale in bovine erythrocytes and tick cells, resulting in the establishment of only one genotype, and appears to be the first report of infection exclusion for Anaplasma and Ehrlichia species...
  21. ncbi Conservation of major surface protein 1 genes of Anaplasma marginale during cyclic transmission between ticks and cattle
    Michael V Bowie
    Department of Pathobiology, University of Florida, PO Box 110880, Gainesville, FL 32611 0880, USA
    Gene 282:95-102. 2002
    ..Several isolate-specific sequences were also observed. Based on the information obtained in this study, the MSP1 protein appears to be fairly well conserved and a potential vaccine candidate...
  22. pmc Citrate synthase gene sequence: a new tool for phylogenetic analysis and identification of Ehrlichia
    H Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 753 8515 Yamaguchi, Japan
    J Clin Microbiol 39:3031-9. 2001
    ..Similarly, Neorickettsia genogroup Ehrlichia species were specifically identified by RFLP patterns of RcaI digestion. If confirmed this technique will be useful in rapidly identifying Ehrlichia spp...
  23. ncbi Molecular phylogeny and biogeography of North American isolates of Anaplasma marginale (Rickettsiaceae: Ehrlichieae)
    J de la Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    Vet Parasitol 97:65-76. 2001
    ..variabilis. These phylogenetic analyses provide information that may be important to consider when developing control strategies for anaplasmosis in the United States...
  24. pmc Strain composition of the ehrlichia Anaplasma marginale within persistently infected cattle, a mammalian reservoir for tick transmission
    G H Palmer
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Clin Microbiol 39:631-5. 2001
    ..The results show that mammalian reservoirs harbor genetically heterogeneous A. marginale and suggest that different genotypes are maintained by transmission within the reservoir population...
  25. pmc Antigenic variation of Anaplasma marginale by expression of MSP2 mosaics
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611 0880, USA
    Infect Immun 68:6133-8. 2000
    ..marginale. A potential mechanism for persistence is segmental gene conversion of the expression site to link hypervariable msp2 sequences to the promoter and polycistron...
  26. pmc Comparison of the nucleotide sequences of 16S rRNA, 444 Ep-ank, and groESL heat shock operon genes in naturally occurring Ehrlichia equi and human granulocytic ehrlichiosis agent isolates from Northern California
    J S Chae
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Clin Microbiol 38:1364-9. 2000
    ..equi isolates from northern California. These results suggest that E. equi and the HGE agent found in California are similar or identical but may differ from the isolates of equine and human origin found in the eastern United States...
  27. pmc Expression of polymorphic msp1beta genes during acute anaplasma Marginale rickettsemia
    M Camacho-Nuez
    Departamento de Genetica y Biologia Molecular, CINVESTAV IPN, D F 07000, Mexico
    Infect Immun 68:1946-52. 2000
    ..These data support testing recombinant vaccines composed of the multiple antigenically and structurally unique MSP1b proteins combined with MSP1a in order to mimic the efficacy of native MSP1 immunization...
  28. pmc Characterization of an immunoreactive protein from the agent of human granulocytic ehrlichiosis
    C P Kolbert
    Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Microbiol 35:1172-8. 1997
    ..Further characterization of the sensitivity and specificity of immune responses to this protein will be facilitated by the use of recombinant fusion proteins or peptides based on the HGE agent-specific groEL homolog...
  29. pmc Expression of major surface protein 2 antigenic variants during acute Anaplasma marginale rickettsemia
    G Eid
    Department of Infectious Diseases, University of Florida, Gainesville, USA
    Infect Immun 64:836-41. 1996
    ..These results support the hypothesis that the large msp-2 gene family, which constitutes a minimum of 1% of the genome, encodes antigenic variants critical to evasion of protective immune response directed against surface MSP-2 epitopes...
  30. ncbi Derivation of the complete msp4 gene sequence of Anaplasma marginale without cloning
    S M Oberle
    Department of Infectious Diseases, University of Florida, Gainesville 32611 0880
    Gene 136:291-4. 1993
    ..This method of sequencing a gene without previously obtaining a clone for that gene could be beneficial in situations where conventional cloning and screening strategies are inefficient or ineffective...
  31. pmc Molecular basis for surface antigen size polymorphisms and conservation of a neutralization-sensitive epitope in Anaplasma marginale
    D R Allred
    Department of Infectious Diseases, University of Florida, Gainesville 32610
    Proc Natl Acad Sci U S A 87:3220-4. 1990
    ..These results identify a basis for size polymorphisms of the surface polypeptide antigen concomitant with B-cell epitope conservation in rickettsiae...
  32. pmc The msp1 beta multigene family of Anaplasma marginale: nucleotide sequence analysis of an expressed copy
    A F Barbet
    Department of Infectious Diseases, College of Veterinary Medicine, University of Florida, Gainesville 32611 0633
    Infect Immun 59:971-6. 1991
    ..The availability of the sequence will allow use of the polymerase chain reaction in diagnostic assays and the preparation and testing of different vaccine constructs in cattle...

Research Grants3

  1. Antigenic variation of Anaplasma marginale
    PATRICK MEEUS; Fiscal Year: 2003
    ..The program provides an excellent framework for the proposed training. ..
  2. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..The sponsor has an active research program in vector borne disease has successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
  3. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2008
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..

Patents12

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  2. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  3. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  4. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
    Patent Number: WO2009077611-A2; Date:2009-06-25
  5. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  6. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  7. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  8. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  9. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  10. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  11. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  12. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27