Babesia bovis T2Bo

Summary

Alias:

Top Publications

  1. pmc Identification, expression and characterisation of a Babesia bovis hexose transporter
    Elvira T Derbyshire
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Mol Biochem Parasitol 161:124-9. 2008
  2. doi Secretion of a new spherical body protein of Babesia bovis into the cytoplasm of infected erythrocytes
    Mohamad Alaa Terkawi
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Mol Biochem Parasitol 178:40-5. 2011
  3. doi Farsenyl pyrophosphate synthase is a potential molecular drug target of risedronate in Babesia bovis
    Akio Ueno
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, 2 13 Inada cho, Obihiro, Hokkaido, Japan
    Parasitol Int 62:189-92. 2013
  4. doi Biochemical characterization of thioredoxin reductase from Babesia bovis
    Erika L Regner
    Instituto de Agrobiotecnología del Litoral UNL CONICET, Facultad de Bioquimica y Ciencias Biologicas, Paraje El Pozo CC 242, S3000ZAA Santa Fe, Argentina
    Biochimie 99:44-53. 2014
  5. pmc Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
    Darren W Begley
    Seattle Structural Genomics Center for Infectious Disease http www ssgcid org, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1070-7. 2011
  6. pmc Characterization of the unusual bidirectional ves promoters driving VESA1 expression and associated with antigenic variation in Babesia bovis
    Xinyi Wang
    Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL, USA
    Eukaryot Cell 11:260-9. 2012

Patents

  1. CONDITIONAL KNOCKOUT MUTANTS OF SORTILIN-LIKE RECEPTOR IN APICOMPLEXAN PARASITES AND USES THEREOF

Scientific Experts

  • Darren W Begley
  • Mohamad Alaa Terkawi
  • Erika L Regner
  • Akio Ueno
  • Mahmoud Aboulaila
  • Xinyi Wang
  • Naoaki Yokoyama
  • Ikuo Igarashi
  • Xuenan Xuan
  • Elvira T Derbyshire
  • Alberto A Iglesias
  • Sergio A Guerrero
  • Carolina S Thompson
  • Diego G Arias
  • Miki Yokoyama
  • Yoshifumi Nishikawa
  • Gabriel Aboge
  • Shinuo Cao
  • Basima Al-Khedery
  • David R Allred
  • HongBin Wang
  • Yu Ping Xiao
  • Anne Bouchut
  • Yuka Minoda
  • Nguyen Xuan Huyen
  • Satoru Kawai
  • Faasoa Junior Seuseu
  • Putut Eko-Wibowo
  • Henry M Staines
  • Sanjeev Krishna
  • Charles J Woodrow
  • Frits J Franssen
  • Erik de Vries
  • Christophe Morin

Detail Information

Publications6

  1. pmc Identification, expression and characterisation of a Babesia bovis hexose transporter
    Elvira T Derbyshire
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Mol Biochem Parasitol 161:124-9. 2008
    ..Taken together with results of inhibition studies with cytochalasin B and beta-glucogallin, these data provide new insights into glucose metabolism of erythrocytic-stage Babesia infections...
  2. doi Secretion of a new spherical body protein of Babesia bovis into the cytoplasm of infected erythrocytes
    Mohamad Alaa Terkawi
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Mol Biochem Parasitol 178:40-5. 2011
    ..Taken together, BbSBP-4 might play an important role as a secreted protein in the intracellular development and/or survival of B. bovis...
  3. doi Farsenyl pyrophosphate synthase is a potential molecular drug target of risedronate in Babesia bovis
    Akio Ueno
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, 2 13 Inada cho, Obihiro, Hokkaido, Japan
    Parasitol Int 62:189-92. 2013
    ..91μM). No regrowth of B. bovis was observed at 10μM of risedronate in the subsequent viability test. These results demonstrate that BbFPPS is the molecular target of risedronate, which could inhibit the in vitro growth of B. bovis...
  4. doi Biochemical characterization of thioredoxin reductase from Babesia bovis
    Erika L Regner
    Instituto de Agrobiotecnología del Litoral UNL CONICET, Facultad de Bioquimica y Ciencias Biologicas, Paraje El Pozo CC 242, S3000ZAA Santa Fe, Argentina
    Biochimie 99:44-53. 2014
    ..We have performed an enzymatic characterization, searching for targets for rational design of inhibitors. This work contributes to the better understanding of the redox biochemistry occurring in the parasite. ..
  5. pmc Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
    Darren W Begley
    Seattle Structural Genomics Center for Infectious Disease http www ssgcid org, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1070-7. 2011
    ..The complexes reveal modes of binding similar to that seen in drug-resistant malaria strains and point to the utility of applying structural studies with proven cancer chemotherapies towards infectious disease research...
  6. pmc Characterization of the unusual bidirectional ves promoters driving VESA1 expression and associated with antigenic variation in Babesia bovis
    Xinyi Wang
    Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL, USA
    Eukaryot Cell 11:260-9. 2012
    ..These results provide a framework to help us begin to understand gene regulation during antigenic variation in B. bovis...

Patents1

  1. CONDITIONAL KNOCKOUT MUTANTS OF SORTILIN-LIKE RECEPTOR IN APICOMPLEXAN PARASITES AND USES THEREOF
    Patent Number: WO2012175410-A1; Date:2012-12-27