Saccharomyces cerevisiae S288c

Summary

Alias:

Top Publications

  1. Arnaudo N, Fern ndez I, McLaughlin S, Peak Chew S, Rhodes D, Martino F. The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle. Nat Struct Mol Biol. 2013;20:1119-21 pubmed publisher
    ..Additionally, we present a new method for the production of protein-nucleosome complexes for structural analysis...
  2. Albert B, Colleran C, L ger Silvestre I, Berger A, Dez C, Normand C, et al. Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human. Nucleic Acids Res. 2013;41:10135-49 pubmed publisher
    ..We propose that Hmo1 has acquired species-specific functions and shares with UBF1 and Sp-Hmo1 an ancestral function to stimulate rDNA transcription...
  3. Pierce J, van der Merwe G, Mangroo D. Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p. Eukaryot Cell. 2014;13:209-30 pubmed publisher
    ..A PKA-independent mechanism was also found to regulate nuclear tRNA export in response to glucose availability. This mechanism, however, does not regulate nuclear reimport of the tRNA export receptors...
  4. Dav A, Cooley C, Garg M, Bianchi A. Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity. Cell Rep. 2014;7:53-61 pubmed publisher
    ..These findings elucidate the mechanism of action of Rif1 in the control of DNA replication and demonstrate a role of PP1 phosphatases in the regulation of origin firing...
  5. Harris J, Nguyen P, Patel M, Sporn Z, Hines J. Functional diversification of hsp40: distinct j-protein functional requirements for two prions allow for chaperone-dependent prion selection. PLoS Genet. 2014;10:e1004510 pubmed publisher
    ..This conservation of function is also prion-variant dependent, indicating that only one of the two Sis1-prion functions may have been maintained in eukaryotic chaperone evolution...
  6. Hyde S, Rao B, Eckenroth B, Jackman J, Doubli S. Structural studies of a bacterial tRNA(HIS) guanylyltransferase (Thg1)-like protein, with nucleotide in the activation and nucleotidyl transfer sites. PLoS ONE. 2013;8:e67465 pubmed publisher
    ..The BtTLP structural data, combined with kinetic analysis of selected variants, provide new insight into the role of key residues in the activation step...
  7. Beznosková P, Cuchalová L, Wagner S, Shoemaker C, Gunisova S, von der Haar T, et al. Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells. PLoS Genet. 2013;9:e1003962 pubmed publisher
    ..Together our work characterizes novel roles of eIF3 and HCR1 in stop codon recognition, defining a communication bridge between the initiation and termination/recycling phases of translation. ..
  8. Desantis M, Sweeny E, Snead D, Leung E, Go M, Gupta K, et al. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. J Biol Chem. 2014;289:848-67 pubmed publisher
    ..Thus, we reveal key differences in how Hsp104 and ClpB coordinate polypeptide handover with Hsp70, which likely reflects differential tuning for yeast and bacterial proteostasis...
  9. Cohen Y, Megyeri M, Chen O, Condomitti G, Riezman I, Loizides Mangold U, et al. The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum. PLoS ONE. 2013;8:e85519 pubmed publisher
    ..Since ATP13A1 is highly expressed in developing neuronal tissues and in the brain, this should help in the study of Mn(2+)-dependent neurological disorders. ..
  10. Srinivasan V, Pierik A, Lill R. Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science. 2014;343:1137-40 pubmed publisher
    ..The resulting protein stabilization may be a common structural feature of all ABC exporters. ..

Detail Information

Publications146 found, 100 shown here

  1. Arnaudo N, Fern ndez I, McLaughlin S, Peak Chew S, Rhodes D, Martino F. The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle. Nat Struct Mol Biol. 2013;20:1119-21 pubmed publisher
    ..Additionally, we present a new method for the production of protein-nucleosome complexes for structural analysis...
  2. Albert B, Colleran C, L ger Silvestre I, Berger A, Dez C, Normand C, et al. Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human. Nucleic Acids Res. 2013;41:10135-49 pubmed publisher
    ..We propose that Hmo1 has acquired species-specific functions and shares with UBF1 and Sp-Hmo1 an ancestral function to stimulate rDNA transcription...
  3. Pierce J, van der Merwe G, Mangroo D. Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p. Eukaryot Cell. 2014;13:209-30 pubmed publisher
    ..A PKA-independent mechanism was also found to regulate nuclear tRNA export in response to glucose availability. This mechanism, however, does not regulate nuclear reimport of the tRNA export receptors...
  4. Dav A, Cooley C, Garg M, Bianchi A. Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity. Cell Rep. 2014;7:53-61 pubmed publisher
    ..These findings elucidate the mechanism of action of Rif1 in the control of DNA replication and demonstrate a role of PP1 phosphatases in the regulation of origin firing...
  5. Harris J, Nguyen P, Patel M, Sporn Z, Hines J. Functional diversification of hsp40: distinct j-protein functional requirements for two prions allow for chaperone-dependent prion selection. PLoS Genet. 2014;10:e1004510 pubmed publisher
    ..This conservation of function is also prion-variant dependent, indicating that only one of the two Sis1-prion functions may have been maintained in eukaryotic chaperone evolution...
  6. Hyde S, Rao B, Eckenroth B, Jackman J, Doubli S. Structural studies of a bacterial tRNA(HIS) guanylyltransferase (Thg1)-like protein, with nucleotide in the activation and nucleotidyl transfer sites. PLoS ONE. 2013;8:e67465 pubmed publisher
    ..The BtTLP structural data, combined with kinetic analysis of selected variants, provide new insight into the role of key residues in the activation step...
  7. Beznosková P, Cuchalová L, Wagner S, Shoemaker C, Gunisova S, von der Haar T, et al. Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells. PLoS Genet. 2013;9:e1003962 pubmed publisher
    ..Together our work characterizes novel roles of eIF3 and HCR1 in stop codon recognition, defining a communication bridge between the initiation and termination/recycling phases of translation. ..
  8. Desantis M, Sweeny E, Snead D, Leung E, Go M, Gupta K, et al. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. J Biol Chem. 2014;289:848-67 pubmed publisher
    ..Thus, we reveal key differences in how Hsp104 and ClpB coordinate polypeptide handover with Hsp70, which likely reflects differential tuning for yeast and bacterial proteostasis...
  9. Cohen Y, Megyeri M, Chen O, Condomitti G, Riezman I, Loizides Mangold U, et al. The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum. PLoS ONE. 2013;8:e85519 pubmed publisher
    ..Since ATP13A1 is highly expressed in developing neuronal tissues and in the brain, this should help in the study of Mn(2+)-dependent neurological disorders. ..
  10. Srinivasan V, Pierik A, Lill R. Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science. 2014;343:1137-40 pubmed publisher
    ..The resulting protein stabilization may be a common structural feature of all ABC exporters. ..
  11. Cheng Y, Chuang C, Shen H, Lin F, Wang T. Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis. Mol Cell Biol. 2013;33:3365-76 pubmed publisher
    ..These results reveal how DNA replication, DSB repair, and chromosome synapsis are differentially monitored by the meiotic checkpoint network. ..
  12. Tsuchiya D, Lacefield S. Cdk1 modulation ensures the coordination of cell-cycle events during the switch from meiotic prophase to mitosis. Curr Biol. 2013;23:1505-13 pubmed publisher
    ..Our study uncovers the essential requirement of Swe1 to modulate CDK activity to coordinate cell-cycle events and maintain genome integrity during the transition from meiotic prophase to mitosis. ..
  13. Oling D, Eisele F, Kvint K, Nystrom T. Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance. EMBO J. 2014;33:747-61 pubmed publisher
    ..We discuss the data in view of how heat stress and aging might elicit differential damage and challenges on the protein homeostasis network. ..
  14. Varabyova A, Topf U, Kwiatkowska P, Wrobel L, Kaus Drobek M, Chacinska A. Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1. FEBS J. 2013;280:4943-59 pubmed publisher
    ..Thus, we identified novel mitochondrial players that are possibly involved in pathological conditions caused by changes in the biogenesis of Sod1. ..
  15. Matos J, Blanco M, West S. Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation. Cell Rep. 2013;4:76-86 pubmed publisher
    ..Therefore, temporal restriction of JM resolution, imposed by Cdk/Cdc5, minimizes the potential for loss of heterozygosity while preventing chromosome missegregation and aneuploidy. ..
  16. Sutter B, Wu X, Laxman S, Tu B. Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A. Cell. 2013;154:403-15 pubmed publisher
    ..Thus, methionine and SAM levels represent a critical gauge of amino acid availability that is sensed via the methylation of PP2A to reciprocally regulate cell growth and autophagy. ..
  17. Yang D, Fang Q, Wang M, Ren R, Wang H, He M, et al. Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat Struct Mol Biol. 2013;20:1116-8 pubmed publisher
    ..By X-ray crystallography, we show here that the acetylated N terminus of Sir3 does not interact with the nucleosome directly. Instead, it stabilizes a nucleosome-binding loop in the BAH domain. ..
  18. Al Husini N, Kudla P, Ansari A. A role for CF1A 3' end processing complex in promoter-associated transcription. PLoS Genet. 2013;9:e1003722 pubmed publisher
    ....
  19. Heo D, Yoo I, Kong J, Lidschreiber M, Mayer A, Choi B, et al. The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome. J Biol Chem. 2013;288:36676-90 pubmed publisher
    ..Thus, the Nrd1 CID couples Ser(P)-5 CTD not only to termination, but also to RNA processing by the nuclear exosome. ..
  20. Lee J, Reiter W, Dohnal I, Gregori C, Beese Sims S, Kuchler K, et al. MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators. Genes Dev. 2013;27:2590-601 pubmed publisher
    ..Thus, these results reveal the mechanism by which Hog1 regulates Fps1 in response to hyperosmotic shock. ..
  21. Khoshnevis S, Gunisova S, Vlčková V, Kouba T, Neumann P, Beznosková P, et al. Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes. Nucleic Acids Res. 2014;42:4123-39 pubmed publisher
    ..Their substitutions with alanines severely impair the mRNA recruitment step in vivo suggesting that a/TIF32-PCI represents one of the key domains ensuring stable and efficient mRNA delivery to the PICs. ..
  22. Ranjha L, Anand R, Cejka P. The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions. J Biol Chem. 2014;289:5674-86 pubmed publisher
    ..This further supports the model where MutLγ is part of a complex acting on joint molecules to generate crossovers in meiosis. ..
  23. Furukawa N, Mima J. Multiple and distinct strategies of yeast SNAREs to confer the specificity of membrane fusion. Sci Rep. 2014;4:4277 pubmed publisher
    ..Thus, our findings uncover multiple and distinct strategies of SNAREs to directly mediate fusion specificity. ..
  24. Lin T, Neuner A, Schlosser Y, Scharf A, Weber L, Schiebel E. Cell-cycle dependent phosphorylation of yeast pericentrin regulates γ-TuSC-mediated microtubule nucleation. elife. 2014;3:e02208 pubmed publisher
    ..The two types of γ-TuCRs contain distinct but conserved C-terminal MTOC targeting domains.DOI: http://dx.doi.org/10.7554/eLife.02208.001. ..
  25. Porrúa O, Libri D. A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast. Nat Struct Mol Biol. 2013;20:884-91 pubmed publisher
    ..We also show that termination is inhibited by RNA-DNA hybrids. Our results elucidate the role of Sen1p in controlling pervasive transcription. ..
  26. Mishra P, Ottmann A, Basrai M. Structural integrity of centromeric chromatin and faithful chromosome segregation requires Pat1. Genetics. 2013;195:369-79 pubmed publisher
    ..Taken together, our data have uncovered a novel role for Pat1 in maintaining the structural integrity of centromeric chromatin to facilitate faithful chromosome segregation and proper kinetochore function. ..
  27. Shestakova A, Curtiss M, Davies B, Katzmann D, Babst M. The linker region plays a regulatory role in assembly and activity of the Vps4 AAA ATPase. J Biol Chem. 2013;288:26810-9 pubmed publisher
    ..This structure would allow the Vps4 complex to engage ESCRT-III subunits with both the pore and the MIT domain simultaneously, which might be essential for the ATP-driven disassembly of ESCRT-III. ..
  28. Hinshaw S, Harrison S. An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation. Cell Rep. 2013;5:29-36 pubmed publisher
    ..We propose that at the core centromere, the Chl4-Iml3 complex participates in recruiting factors, such as Sgo1, that influence sister chromatid cohesion and encourage sister kinetochore biorientation. ..
  29. Rodríguez Peña J, Diez Muñiz S, Bermejo C, Nombela C, Arroyo J. Activation of the yeast cell wall integrity MAPK pathway by zymolyase depends on protease and glucanase activities and requires the mucin-like protein Hkr1 but not Msb2. FEBS Lett. 2013;587:3675-80 pubmed publisher
    ..Moreover, we show that the osmosensor Hkr1 is required for signaling, being the most upstream element identified to date. ..
  30. Bhaskar V, Roudko V, Basquin J, Sharma K, Urlaub H, Seraphin B, et al. Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex. Nat Struct Mol Biol. 2013;20:1281-8 pubmed publisher
    ..The ternary complex forms a composite surface that binds poly(U) RNA in vitro, with a site at the Not5 Not box. The results suggest that the Not module forms a versatile platform for macromolecular interactions. ..
  31. Babazadeh R, Adiels C, Smedh M, Petelenz Kurdziel E, Goksör M, Hohmann S. Osmostress-induced cell volume loss delays yeast Hog1 signaling by limiting diffusion processes and by Hog1-specific effects. PLoS ONE. 2013;8:e80901 pubmed publisher
    ..In addition, there may be mechanisms slowing down especially Hog1 nuclear translocation under severe stress in order to prioritize Hog1 cytosolic targets. ..
  32. Sharma S, Yang J, Düttmann S, Watzinger P, Kötter P, Entian K. Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae. Nucleic Acids Res. 2014;42:3246-60 pubmed publisher
    ..With Bmt5 and Bmt6, all base methyltransferases of the 25S rRNA have been identified. This will facilitate the analyses of the significance of these modifications in ribosome function and cellular physiology. ..
  33. Wilkins B, Rall N, Ostwal Y, Kruitwagen T, Hiragami Hamada K, Winkler M, et al. A cascade of histone modifications induces chromatin condensation in mitosis. Science. 2014;343:77-80 pubmed publisher
    ..This cascade of events provides a condensin-independent driving force of chromatin hypercondensation during mitosis. ..
  34. Takeda M, Yamagami K, Tanaka K. Role of phosphatidylserine in phospholipid flippase-mediated vesicle transport in Saccharomyces cerevisiae. Eukaryot Cell. 2014;13:363-75 pubmed publisher
    ..These results suggest that flippase-dependent vesicle formation is mediated by phospholipid flipping, not by flipped phospholipids. ..
  35. Pathare G, Nagy I, Sledź P, Anderson D, Zhou H, Pardon E, et al. Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11. Proc Natl Acad Sci U S A. 2014;111:2984-9 pubmed publisher
    ..The narrow space around the Rpn11 active site at the entrance to the ATPase ring pore is likely to prevent erroneous deubiquitylation of folded proteins. ..
  36. Kuo C, Savage N, Chen H, Wu C, Zyla T, Lew D. Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuit. Curr Biol. 2014;24:753-9 pubmed publisher
    ..These findings reveal a mechanism for negative feedback and suggest that the function of negative feedback via GEF inhibition is to buffer the level of Cdc42 at the polarity site. ..
  37. Mattarocci S, Shyian M, Lemmens L, Damay P, Altintas D, Shi T, et al. Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7. Cell Rep. 2014;7:62-9 pubmed publisher
    ..Our data thus link Rif1 to negative regulation of replication origin firing through recruitment of the Glc7 phosphatase. ..
  38. Liang Y, Lavoie M, Comeau M, Abou Elela S, Ji X. Structure of a eukaryotic RNase III postcleavage complex reveals a double-ruler mechanism for substrate selection. Mol Cell. 2014;54:431-44 pubmed publisher
    ..These findings provide a framework for understanding eukaryotic RNase IIIs. ..
  39. Simon A, Zhou J, Perera R, van Deursen F, Evrin C, Ivanova M, et al. A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome. Nature. 2014;510:293-297 pubmed publisher
    ..The ability of Ctf4 to act as a platform for multivalent interactions illustrates a mechanism for the concurrent recruitment of factors that act together at the fork. ..
  40. Caydasi A, Micoogullari Y, Kurtulmus B, Palani S, Pereira G. The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes. Mol Biol Cell. 2014;25:2143-51 pubmed publisher
    ..Consistently, BMH1-null cells are SPOC deficient. Our work thus identifies Bmh1 as a new SPOC component and refines the molecular mechanism that breaks Bfa1 centrosome asymmetry upon SPOC activation. ..
  41. Eng T, Guacci V, Koshland D. ROCC, a conserved region in cohesin's Mcd1 subunit, is essential for the proper regulation of the maintenance of cohesion and establishment of condensation. Mol Biol Cell. 2014;25:2351-64 pubmed publisher
    ..We provide evidence that ROCC controls cohesion maintenance and condensation establishment through differential functional interactions with Pds5p and Wpl1p. ..
  42. Tudek A, Porrúa O, Kabzinski T, Lidschreiber M, Kubicek K, Fortova A, et al. Molecular basis for coordinating transcription termination with noncoding RNA degradation. Mol Cell. 2014;55:467-81 pubmed publisher
    ..We propose that transcription termination and RNA degradation are coordinated by switching between two alternative partners of the NNS complex. ..
  43. Hoch N, Chen E, Buckland R, Wang S, Fazio A, Hammet A, et al. Molecular basis of the essential s phase function of the rad53 checkpoint kinase. Mol Cell Biol. 2013;33:3202-13 pubmed publisher
    ..Our findings indicate that the essential S phase function of Rad53 is comprised by the combination of its role in regulating basal dNTP levels and its compensatory kinase function if dNTP levels are perturbed. ..
  44. Chen Y, Szakal B, Castellucci F, Branzei D, Zhao X. DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants. Mol Biol Cell. 2013;24:2431-41 pubmed publisher
    ....
  45. Swinehart W, Henderson J, Jackman J. Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10. RNA. 2013;19:1137-46 pubmed publisher
    ....
  46. Sharma S, Yang J, Watzinger P, Kötter P, Entian K. Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. Nucleic Acids Res. 2013;41:9062-76 pubmed publisher
    ....
  47. London N, Biggins S. Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint. Genes Dev. 2014;28:140-52 pubmed publisher
    ..The Mad1 interaction with Bub1 and kinetochores can be reconstituted in the presence of Mps1 and Mad2. Together, this work reveals a critical mechanism that determines kinetochore activation of the spindle checkpoint. ..
  48. Pimentel C, Caetano S, Menezes R, Figueira I, Santos C, Ferreira R, et al. Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2014;1840:1977-86 pubmed publisher
    ..Cobalt has a rare occurrence in nature, but may accumulate in cells to toxic levels. In the present study, we have investigated how the transcription factor Yap1 mediates tolerance to cobalt toxicity...
  49. Schwer B, Shuman S. Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28. Nucleic Acids Res. 2014;42:4697-711 pubmed publisher
    ..YHC1-(1-170) was synthetically lethal with mutations of all components interrogated, with the exception of Nam8. ..
  50. Park S, Kukushkin Y, Gupta R, Chen T, Konagai A, Hipp M, et al. PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone. Cell. 2013;154:134-45 pubmed publisher
    ..Upon depletion of Sis1p by polyQ aggregation, misfolded proteins are barred from entering the nucleus and form cytoplasmic inclusions. ..
  51. Back R, Dominguez C, Rothé B, Bobo C, Beaufils C, Morera S, et al. High-resolution structural analysis shows how Tah1 tethers Hsp90 to the R2TP complex. Structure. 2013;21:1834-47 pubmed publisher
    ..The Tah1 C-terminal region is unfolded, and we demonstrate that it is essential for the recruitment of the Pih1 C-terminal domain and folds upon binding...
  52. Harris B, Bose T, Lee K, Wang F, Lu S, Ross R, et al. Cohesion promotes nucleolar structure and function. Mol Biol Cell. 2014;25:337-46 pubmed publisher
    ..Our results strongly suggest that organization of the rDNA provided by cohesion is critical for formation and function of the nucleolus. ..
  53. Watanabe T, Irokawa H, Ogasawara A, Iwai K, Kuge S. Requirement of peroxiredoxin on the stationary phase of yeast cell growth. J Toxicol Sci. 2014;39:51-8 pubmed
    ..Our results suggest that ROS levels are not responsible for the growth phenotype. Tsa1 might have a specific function that could not be replaced by Ahp1. ..
  54. Roig M, Lowe J, Chan K, Beckouët F, Metson J, Nasmyth K. Structure and function of cohesin's Scc3/SA regulatory subunit. FEBS Lett. 2014;588:3692-702 pubmed publisher
    ..Scc3 turns over in G2/M while maintaining cohesin's association with chromosomes and it promotes de-acetylation of Smc3 upon Scc1 cleavage. ..
  55. Schroeder E, Raimundo N, Shadel G. Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab. 2013;17:954-64 pubmed publisher
    ..These results demonstrate the existence of conserved mitochondria-to-nucleus stress-signaling pathways that regulate aging through epigenetic modulation of nuclear gene expression. ..
  56. Platt J, Ryvkin P, Wanat J, Donahue G, Ricketts M, Barrett S, et al. Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence. Genes Dev. 2013;27:1406-20 pubmed publisher
    ..Rap1 relocalization is thus a novel mechanism connecting DNA damage responses (DDRs) at telomeres to global changes in chromatin and gene expression while driving the pace of senescence. ..
  57. Nasuno R, Hirano Y, Itoh T, Hakoshima T, Hibi T, Takagi H. Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism. Proc Natl Acad Sci U S A. 2013;110:11821-6 pubmed publisher
    ..These studies provide some benefits of Mpr1 applications, such as the breeding of industrial yeasts and the development of antifungal drugs. ..
  58. Su X, Arellano Santoyo H, Portran D, Gaillard J, Vantard M, Thery M, et al. Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control. Nat Cell Biol. 2013;15:948-57 pubmed publisher
    ..This facilitates normal spindle assembly. However, the destabilizing activity of Kip3 dominates in late anaphase, inhibiting spindle elongation and ultimately promoting spindle disassembly. ..
  59. Ma W, Westmoreland J, Resnick M. Homologous recombination rescues ssDNA gaps generated by nucleotide excision repair and reduced translesion DNA synthesis in yeast G2 cells. Proc Natl Acad Sci U S A. 2013;110:E2895-904 pubmed publisher
    ..These findings suggest that ssDNA that might originate during the repair of closely opposed lesions or of ssDNA-containing lesions or from uncoupled replication may drive recombination directly in various species, including humans. ..
  60. McStay G, Su C, Thomas S, Xu J, Tzagoloff A. Characterization of assembly intermediates containing subunit 1 of yeast cytochrome oxidase. J Biol Chem. 2013;288:26546-56 pubmed publisher
    ....
  61. Knoblach B, Sun X, Coquelle N, Fagarasanu A, Poirier R, Rachubinski R. An ER-peroxisome tether exerts peroxisome population control in yeast. EMBO J. 2013;32:2439-53 pubmed publisher
    ..Peroxisomes are thus stably maintained over generations of cells through their continued interaction with tethers. ..
  62. Papic D, Elbaz Alon Y, Koerdt S, Leopold K, Worm D, Jung M, et al. The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein. Mol Cell Biol. 2013;33:4083-94 pubmed publisher
    ..Taking our results together, we identified Tom70 and Djp1 as crucial players in the biogenesis of Mim1. Moreover, the involvement of Djp1 provides a unique case of specificity between a cochaperone and its substrate protein. ..
  63. Saka K, Ide S, Ganley A, Kobayashi T. Cellular senescence in yeast is regulated by rDNA noncoding transcription. Curr Biol. 2013;23:1794-8 pubmed publisher
    ..The observation of rDNA instability in other organisms, including humans, suggests that this may be a conserved aging pathway. ..
  64. Wilson M, Kwon Y, Xu Y, Chung W, Chi P, Niu H, et al. Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration. Nature. 2013;502:393-6 pubmed publisher
    ..Our results uncover a novel function of Pif1 and provide insights into the mechanism of HR. ..
  65. Smith S, Rubinstein B, Mendes Pinto I, Slaughter B, Unruh J, Li R. Independence of symmetry breaking on Bem1-mediated autocatalytic activation of Cdc42. J Cell Biol. 2013;202:1091-106 pubmed publisher
    ..The model predicts a nonmonotonic dependence of cell polarization on the concentration of Rdi1 relative to that of Cdc42. ..
  66. Herndon J, Claypool S, Koehler C. The Taz1p transacylase is imported and sorted into the outer mitochondrial membrane via a membrane anchor domain. Eukaryot Cell. 2013;12:1600-8 pubmed publisher
    ..These studies suggest that altering the mitochondrial import pathway of Taz1p may be important in understanding the molecular basis of Barth syndrome. ..
  67. Furniss K, Tsai H, Byl J, Lane A, Vas A, Hsu W, et al. Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. PLoS Genet. 2013;9:e1003832 pubmed publisher
    ..In contrast, we have described the first example of a distinct category of checkpoint mechanism that monitors the catalytic cycle of a single specific enzyme in order to determine when chromosome segregation can proceed faithfully. ..
  68. Colombi P, Webster B, Fröhlich F, Lusk C. The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1. J Cell Biol. 2013;203:215-32 pubmed publisher
    ..It further supports the finding that NPC inheritance, not de novo NPC assembly, is primarily responsible for controlling NPC number in daughter cells. ..
  69. Kõivomägi M, Ord M, Iofik A, Valk E, Venta R, Faustova I, et al. Multisite phosphorylation networks as signal processors for Cdk1. Nat Struct Mol Biol. 2013;20:1415-24 pubmed publisher
    ....
  70. Romanova N, Crouse G. Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast. PLoS Genet. 2013;9:e1003920 pubmed publisher
    ..MutSβ is present in many eukaryotic organisms, but not in prokaryotes. We suggest that the biased repair of deletion mispairs may reflect a critical eukaryotic function of MutSβ in mismatch repair. ..
  71. De Silva D, Fontanesi F, Barrientos A. The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit. Cell Metab. 2013;18:712-25 pubmed publisher
    ..We conclude that Mrh4 plays an essential role during the late stages of mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. ..
  72. Cooper K, Khakhina S, Kim S, Strich R. Stress-induced nuclear-to-cytoplasmic translocation of cyclin C promotes mitochondrial fission in yeast. Dev Cell. 2014;28:161-73 pubmed publisher
    ..This study provides a mechanism by which stress-induced gene induction and mitochondrial fission are coordinated through translocation of cyclin C. ..
  73. Eissler C, Mazon G, Powers B, Savinov S, Symington L, Hall M. The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability. Mol Cell. 2014;54:80-93 pubmed publisher
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