Saccharomyces

Summary

Alias: Pachytichospora

Top Publications

  1. Yoshida S, Anraku Y. Characterization of staurosporine-sensitive mutants of Saccharomyces cerevisiae: vacuolar functions affect staurosporine sensitivity. Mol Gen Genet. 2000;263:877-88 pubmed
    Mutations at several loci affect the sensitivity of the yeast Saccharomyces cerevisiae to staurosporine. We report here the characterization of novel staurosporine- and temperature-sensitive mutants (stt)...
  2. Saito K, Fujimura Kamada K, Furuta N, Kato U, Umeda M, Tanaka K. Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae. Mol Biol Cell. 2004;15:3418-32 pubmed
    ..Thus, phospholipid asymmetry plays an important role in the establishment of cell polarity; the Cdc50p/Lem3p family likely constitute potential subunits specific to unique P-type ATPases of the APT subfamily...
  3. Anderson J, Ricker N, Sirjusingh C. Antagonism between two mechanisms of antifungal drug resistance. Eukaryot Cell. 2006;5:1243-51 pubmed
    This study tested for interaction between two independently evolved mechanisms of fluconazole resistance in Saccharomyces cerevisiae...
  4. Mollapour M, Piper P. Activity of the yeast zinc-finger transcription factor War1 is lost with alanine mutation of two putative phosphorylation sites in the activation domain. Yeast. 2012;29:39-44 pubmed publisher
    b>Saccharomyces cerevisiae acquires its resistance to carboxylate weak organic acids by inducing a plasma membrane ABC transporter, Pdr12...
  5. Paumi C, Pickin K, Jarrar R, Herren C, Cowley S. Ycf1p attenuates basal level oxidative stress response in Saccharomyces cerevisiae. FEBS Lett. 2012;586:847-53 pubmed publisher
    ..Our results suggest that during acute salt stress increased Sod1p, Sod2p and Ctt1p activity is the main compensatory for the loss in Ycf1p function that results from reduced Ycf1p-dependent recycling of cellular GSH levels...
  6. Lee S, Oh M. Improved production of N-acetylglucosamine in Saccharomyces cerevisiae by reducing glycolytic flux. Biotechnol Bioeng. 2016;113:2524-8 pubmed publisher
    ..We previously demonstrated production of N-acetylglucosamine (GlcNAc) in Saccharomyces cerevisiae by overexpressing an allosteric regulation-free Gfa1p mutant and the haloacid dehalogenase-like ..
  7. Pyne M, Narcross L, Fossati E, Bourgeois L, Burton E, Gold N, et al. Reconstituting Plant Secondary Metabolism in Saccharomyces cerevisiae for Production of High-Value Benzylisoquinoline Alkaloids. Methods Enzymol. 2016;575:195-224 pubmed publisher
    ..Here, we provide a technical basis for reconstituting BIA biosynthetic pathways in the common yeast Saccharomyces cerevisiae...
  8. Rosenwald A, Arora G, Ferrandino R, Gerace E, Mohammednetej M, Nosair W, et al. Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor. G3 (Bethesda). 2016;6:2893-907 pubmed publisher
    ..Four of the genes identified as causing sensitivity are orthologs of Saccharomyces cerevisiae genes encoding proteins important for the cell wall integrity (CWI) pathway...
  9. Golovko A, Kojukhov A, Guan B, Morpurgo B, Merrick W, Mazumder B, et al. The eIF2A knockout mouse. Cell Cycle. 2016;15:3115-3120 pubmed
    ..The yeast Saccharomyces cerevisae eIF2A null mutant revealed no apparent phenotype, however, it was found that in yeast eIF2A ..
  10. Mónico A, Nim S, Duarte N, Rawal M, Prasad R, Di Pietro A, et al. Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model. Bioorg Med Chem. 2017;25:3278-3284 pubmed publisher
    ..The transport assay was performed by monitoring Nile Red (NR) efflux in a Saccharomyces cerevisiae strain overexpressing the referred efflux pumps from C. albicans...

Detail Information

Publications170 found, 100 shown here

  1. Yoshida S, Anraku Y. Characterization of staurosporine-sensitive mutants of Saccharomyces cerevisiae: vacuolar functions affect staurosporine sensitivity. Mol Gen Genet. 2000;263:877-88 pubmed
    Mutations at several loci affect the sensitivity of the yeast Saccharomyces cerevisiae to staurosporine. We report here the characterization of novel staurosporine- and temperature-sensitive mutants (stt)...
  2. Saito K, Fujimura Kamada K, Furuta N, Kato U, Umeda M, Tanaka K. Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae. Mol Biol Cell. 2004;15:3418-32 pubmed
    ..Thus, phospholipid asymmetry plays an important role in the establishment of cell polarity; the Cdc50p/Lem3p family likely constitute potential subunits specific to unique P-type ATPases of the APT subfamily...
  3. Anderson J, Ricker N, Sirjusingh C. Antagonism between two mechanisms of antifungal drug resistance. Eukaryot Cell. 2006;5:1243-51 pubmed
    This study tested for interaction between two independently evolved mechanisms of fluconazole resistance in Saccharomyces cerevisiae...
  4. Mollapour M, Piper P. Activity of the yeast zinc-finger transcription factor War1 is lost with alanine mutation of two putative phosphorylation sites in the activation domain. Yeast. 2012;29:39-44 pubmed publisher
    b>Saccharomyces cerevisiae acquires its resistance to carboxylate weak organic acids by inducing a plasma membrane ABC transporter, Pdr12...
  5. Paumi C, Pickin K, Jarrar R, Herren C, Cowley S. Ycf1p attenuates basal level oxidative stress response in Saccharomyces cerevisiae. FEBS Lett. 2012;586:847-53 pubmed publisher
    ..Our results suggest that during acute salt stress increased Sod1p, Sod2p and Ctt1p activity is the main compensatory for the loss in Ycf1p function that results from reduced Ycf1p-dependent recycling of cellular GSH levels...
  6. Lee S, Oh M. Improved production of N-acetylglucosamine in Saccharomyces cerevisiae by reducing glycolytic flux. Biotechnol Bioeng. 2016;113:2524-8 pubmed publisher
    ..We previously demonstrated production of N-acetylglucosamine (GlcNAc) in Saccharomyces cerevisiae by overexpressing an allosteric regulation-free Gfa1p mutant and the haloacid dehalogenase-like ..
  7. Pyne M, Narcross L, Fossati E, Bourgeois L, Burton E, Gold N, et al. Reconstituting Plant Secondary Metabolism in Saccharomyces cerevisiae for Production of High-Value Benzylisoquinoline Alkaloids. Methods Enzymol. 2016;575:195-224 pubmed publisher
    ..Here, we provide a technical basis for reconstituting BIA biosynthetic pathways in the common yeast Saccharomyces cerevisiae...
  8. Rosenwald A, Arora G, Ferrandino R, Gerace E, Mohammednetej M, Nosair W, et al. Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor. G3 (Bethesda). 2016;6:2893-907 pubmed publisher
    ..Four of the genes identified as causing sensitivity are orthologs of Saccharomyces cerevisiae genes encoding proteins important for the cell wall integrity (CWI) pathway...
  9. Golovko A, Kojukhov A, Guan B, Morpurgo B, Merrick W, Mazumder B, et al. The eIF2A knockout mouse. Cell Cycle. 2016;15:3115-3120 pubmed
    ..The yeast Saccharomyces cerevisae eIF2A null mutant revealed no apparent phenotype, however, it was found that in yeast eIF2A ..
  10. Mónico A, Nim S, Duarte N, Rawal M, Prasad R, Di Pietro A, et al. Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model. Bioorg Med Chem. 2017;25:3278-3284 pubmed publisher
    ..The transport assay was performed by monitoring Nile Red (NR) efflux in a Saccharomyces cerevisiae strain overexpressing the referred efflux pumps from C. albicans...
  11. Lan W, Lin Y, Men Z, Yan L. Surface-decorated S. cerevisiae for flow cytometric array immunoassay. Anal Bioanal Chem. 2017;409:5259-5267 pubmed publisher
    ..This study describes a surface-decorated Saccharomyces cerevisiae for flow cytometric array immunoassay. S...
  12. De La Torre M, Martín Sampedro R, Fillat U, Eugenio M, Blánquez A, Hernandez M, et al. Comparison of the efficiency of bacterial and fungal laccases in delignification and detoxification of steam-pretreated lignocellulosic biomass for bioethanol production. J Ind Microbiol Biotechnol. 2017;44:1561-1573 pubmed publisher
    ..The phenols reduction resulted in an improved performance of Saccharomyces cerevisiae during a simultaneous saccharification and fermentation (SSF) process, improving ethanol production ..
  13. Becker B, Schmitt M. Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing. Toxins (Basel). 2017;9: pubmed publisher
    The initial discovery of killer toxin-secreting brewery strains of Saccharomyces cerevisiae (S. cerevisiae) in the mid-sixties of the last century marked the beginning of intensive research in the yeast virology field...
  14. Michel C, Ngoune V, Poch O, Ripp R, Thompson J. Enrichment of Circular Code Motifs in the Genes of the Yeast Saccharomyces cerevisiae. Life (Basel). 2017;7: pubmed publisher
    ..e., motifs from the circular code X, in the complete genome of the yeast Saccharomyces cerevisiae...
  15. Gaskova D, Cadek R, Chaloupka R, Vacata V, Gebel J, Sigler K. Monitoring the kinetics and performance of yeast membrane ABC transporters by diS-C3(3) fluorescence. Int J Biochem Cell Biol. 2002;34:931-7 pubmed
    ..The monitoring was done with Saccharomyces cerevisiae mutants AD1-8 and AD1-3 deleted in different ABC pumps, and in their pump-competent parent strain ..
  16. Wawrzycka D. [The ABC transporters of Saccharomyces cerevisiae]. Postepy Biochem. 2011;57:324-32 pubmed
    ..The ABC superfamily contains transporters, canals, receptors. Analysis of the Saccharomyces cerevisiae genome allowed to distinguish 30 potential ABC proteins which are classified into 6 subfamilies...
  17. Dolch L, Rak C, Perin G, Tourcier G, Broughton R, Leterrier M, et al. A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis. Plant Physiol. 2017;173:742-759 pubmed publisher
    ..in this pathway, we characterized the highly expressed isoform Δ0-ELO1 Heterologous expression in yeast (Saccharomyces cerevisiae) showed that NgΔ0-ELO1 could elongate palmitic acid...
  18. Pan T, Liu C, Zeng X, Xin Q, Xu M, Deng Y, et al. Biotoxicity and bioavailability of hydrophobic organic compounds solubilized in nonionic surfactant micelle phase and cloud point system. Environ Sci Pollut Res Int. 2017;24:14795-14801 pubmed publisher
    ..b>Saccharomyces cerevisiae, unable to degrade these compounds, was used for the biotoxicity experiments...
  19. Liu J, Li J, Shin H, Du G, Chen J, Liu L. Metabolic engineering of Aspergillus oryzae for efficient production of l-malate directly from corn starch. J Biotechnol. 2017;262:40-46 pubmed publisher
    ..In addition, to reduce the concentration of byproducts succinate and fumarate, a fumarase from Saccharomyces cerevisiae, which facilitated the transformation of fumarate to l-malate, was overexpressed...
  20. Reyes L, Kao K. Growth-Coupled Carotenoids Production Using Adaptive Laboratory Evolution. Methods Mol Biol. 2018;1671:319-330 pubmed publisher
    ..In this book chapter, we describe an effective adaptive laboratory evolution strategy for improving product formation of carotenoids, a class of compounds with antioxidant potential, in the yeast Saccharomyces cerevisiae.
  21. Maciaszczyk Dziubinska E, Migdal I, Migocka M, Bocer T, Wysocki R. The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channel. FEBS Lett. 2010;584:726-32 pubmed publisher
    ..kinase Hog1p mediates arsenic tolerance by decreasing arsenite influx through the aquaglyceroporin Fps1p in Saccharomyces cerevisiae...
  22. Noble J, Tsai H, Suffis S, Su Q, Myers T, Bennett J. STB5 is a negative regulator of azole resistance in Candida glabrata. Antimicrob Agents Chemother. 2013;57:959-67 pubmed publisher
    ..Studies in the related yeast Saccharomyces cerevisiae have shown that Pdr1p forms a heterodimer with another transcription factor, Stb5p. In C...
  23. Zhu S, Wang J, Cai M, Zhang H, Wu F, Xu Y, et al. The OsHAPL1-DTH8-Hd1 complex functions as the transcription regulator to repress heading date in rice. J Exp Bot. 2017;68:553-568 pubmed publisher
    ..DTH8, and Hd1 physically interact with the HAP complex, and also with general transcription factors in yeast (Saccharomyces cerevisiae)...
  24. Boudoures A, Pfeil J, Steenkiste E, Hoffman R, Bailey E, Wilkes S, et al. A Novel Histone Crosstalk Pathway Important for Regulation of UV-Induced DNA Damage Repair in Saccharomyces cerevisiae. Genetics. 2017;206:1389-1402 pubmed publisher
    ..Here, we report that H3K79 methylation is reduced in response to UV exposure in Saccharomyces cerevisiae This reduction is specific to the dimethylated state, as trimethylation levels are minimally ..
  25. Shedlovskiy D, Shcherbik N, Pestov D. One-step hot formamide extraction of RNA from Saccharomyces cerevisiae. RNA Biol. 2017;14:1722-1726 pubmed publisher
    ..The formamide-EDTA extraction of yeast RNA is faster, safer, and more economical than conventional methods, outperforms them in terms of total yield, and greatly increases throughput...
  26. Li B, Liao B. Protein Complexes Prediction Method Based on Core-Attachment Structure and Functional Annotations. Int J Mol Sci. 2017;18: pubmed publisher
    ..and three sets of real complexes including the Munich Information Center for Protein Sequences (MIPS), the Saccharomyces Genome Database (SGD) and the Catalogues of Yeast protein Complexes (CYC2008) are selected as benchmark sets, ..
  27. Cardarelli S, Giorgi M, Naro F, Malatesta F, Biagioni S, Saliola M. Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis. Microb Cell Fact. 2017;16:159 pubmed publisher
    ..Kluyveromyces lactis, one of the few yeasts capable of utilizing lactose, is an attractive host alternative to Saccharomyces cerevisiae for heterologous protein production. Here we established K...
  28. Ohashi K, Chaleckis R, Takaine M, Wheelock C, Yoshida S. Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae. Sci Rep. 2017;7:12180 pubmed publisher
    ..In conclusion, we propose that KAT activity is required for detoxification of Trp by converting it to the less toxic KA. ..
  29. Karuppasamy M, Kusmider B, Oliveira T, Gaubitz C, Prouteau M, Loewith R, et al. Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2. Nat Commun. 2017;8:1729 pubmed publisher
    ..Here, we present the structure of Saccharomyces cerevisiae TORC2 determined by electron cryo-microscopy. TORC2 contains six subunits assembling into a 1...
  30. Molon M, Woźnicka O, Zebrowski J. Cell wall biosynthesis impairment affects the budding lifespan of the Saccharomyces cerevisiae yeast. Biogerontology. 2018;19:67-79 pubmed publisher
    The Saccharomyces cerevisiae yeast is one of the most widely used model in studies of cellular and organismal biology, including as aging and proliferation...
  31. Bjørkskov F, Krabbe S, Nurup C, Missel J, Spulber M, Bomholt J, et al. Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization. Sci Rep. 2017;7:16899 pubmed publisher
    ..In conclusion, our S. cerevisiae platform emerges as a powerful tool for isolation of functional, difficult-to-express human membrane proteins suitable for biophysical characterization. ..
  32. Rozbeský D, Rosulek M, Kukačka Z, Chmelik J, Man P, Novak P. Impact of Chemical Cross-Linking on Protein Structure and Function. Anal Chem. 2017;: pubmed publisher
    ..impact of cross-linking on structure and function of human carbonic anhydrase and alcohol dehydrogenase 1 from Saccharomyces cerevisiae...
  33. Trcek T, Rahman S, Zenklusen D. Measuring mRNA Decay in Budding Yeast Using Single Molecule FISH. Methods Mol Biol. 2018;1720:35-54 pubmed publisher
    ..Here, we provide a step-by-step protocol that allows quantification of mRNA decay in single Saccharomyces cerevisiae using smFISH...
  34. Bonnefoy N, Kermorgant M, Brivet Chevillotte P, Dujardin G. Cloning by functional complementation, and inactivation, of the Schizosaccharomyces pombe homologue of the Saccharomyces cerevisiae gene ABC1. Mol Gen Genet. 1996;251:204-10 pubmed
    The Saccharomyces cerevisiae gene ABC1 is required for the correct functioning of the bc1 complex of the mitochondrial respiratory chain. By functional complementation of a S...
  35. Tsujimoto Y, Takase D, Okano H, Tomari N, Watanabe K, Matsui H. Functional roles of YPT31 and YPT32 in clotrimazole resistance of Saccharomyces cerevisiae through effects on vacuoles and ATP-binding cassette transporter(s). J Biosci Bioeng. 2013;115:4-11 pubmed publisher
    ..These results indicated that Ypt31p and Ypt32p played minor but compensatory roles in cellular resistance to CTZ through vacuoles and specific ABC transporter(s) other than Pdr5p...
  36. Yamamoto N, Kudo T, Fujiwara S, Takatsuka Y, Hirokawa Y, Tsuzuki M, et al. Pleurochrysome: A Web Database of Pleurochrysis Transcripts and Orthologs Among Heterogeneous Algae. Plant Cell Physiol. 2016;57:e6 pubmed publisher
    ..frames and orthologous relationship with genes of 10 other algal species, a cyanobacterium and the yeast Saccharomyces cerevisiae. This sequence and annotation information can be easily accessed via several search functions...
  37. Maillet J, Ottaviani S, Tubach F, Roy C, Nicaise Rolland P, Palazzo E, et al. Anti-Saccharomyces cerevisiae antibodies (ASCA) in spondyloarthritis: Prevalence and associated phenotype. Joint Bone Spine. 2016;83:665-668 pubmed publisher
    ..The aim of the study was to compare the prevalence of ASCA in spondyloarthrites (SpA) patients and to investigate the association between ASCA status and disease phenotype...
  38. Wei Y, Xia X. The Role of +4U as an Extended Translation Termination Signal in Bacteria. Genetics. 2017;205:539-549 pubmed publisher
    ..In both Escherichia coli and Saccharomyces cerevisiae, termination read-through is reduced in the presence of +4U; however, the molecular mechanism ..
  39. Gates S, Yokom A, Lin J, Jackrel M, Rizo A, Kendsersky N, et al. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 2017;357:273-279 pubmed publisher
    ..The Hsp104 disaggregase from Saccharomyces cerevisiae solubilizes stress-induced amorphous aggregates and amyloids...
  40. Hoffman R, Grabinska K, Guan Z, Sessa W, Neiman A. Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae. Genetics. 2017;: pubmed publisher
    ..In Saccharomyces cerevisiae, there are two cis-prenyltransferases that synthesize polyprenol, an essential precursor ..
  41. Ishibashi K, Matsumoto Yokoyama E, Ishikawa M. A Tomato Spotted Wilt Virus S RNA-based Replicon System in Yeast. Sci Rep. 2017;7:12647 pubmed publisher
    ..Here, we report that RNA synthesis by TSWV RNA polymerase occurs in the yeast Saccharomyces cerevisiae using a segment of the TSWV genome, S RNA expressed from cloned cDNA, as a template...
  42. Howe F, Russell A, Lamstaes A, El Sagheer A, Nair A, Brown T, et al. CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape. elife. 2017;6: pubmed publisher
    ..At HMS2 in Saccharomyces cerevisiae, sgRNA/dCas9 targeting to the non-template strand for antisense transcription results in ..
  43. Han L, Peng Y, Zhang Y, Chen W, Lin Y, Wang Q. Designing and Creating a Synthetic Omega Oxidation Pathway in Saccharomyces cerevisiae Enables Production of Medium-Chain α, ω-Dicarboxylic Acids. Front Microbiol. 2017;8:2184 pubmed publisher
    ..Here, we designed and created a synthetic omega oxidation pathway in Saccharomyces cerevisiae to produce C10 and C12 α, ω-DCAs from renewable sugars and fatty acids by introducing a ..
  44. Kita R, Venkataram S, Zhou Y, Fraser H. High-resolution mapping of cis-regulatory variation in budding yeast. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
    ..Here we report RNA-seq and full genome sequences for 85 diverse isolates of the yeast Saccharomyces cerevisiae-including wild, domesticated, and human clinical strains-which allowed us to perform eQTL ..
  45. Saka K, Takahashi A, Sasaki M, Kobayashi T. More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance. Nucleic Acids Res. 2016;44:4211-21 pubmed publisher
    ..identify eukaryotic factors that connect reduced genome stability to senescence we screened 4,876 strains of a Saccharomyces cerevisiae deletion library for aberrant rDNA and found 708 genes that contribute to its upkeep...
  46. Jin M, Sarks C, Bals B, Posawatz N, Gunawan C, Dale B, et al. Toward high solids loading process for lignocellulosic biofuel production at a low cost. Biotechnol Bioeng. 2017;114:980-989 pubmed publisher
    ..ammonia fiber expansion) pretreated corn stover for ethanol production using a xylose fermenting strain Saccharomyces cerevisiae 424A(LNH-ST)...
  47. Kurdzo E, Obeso D, Chuong H, Dawson D. Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae. Genetics. 2017;205:657-671 pubmed publisher
    ..In the budding yeast, Saccharomyces cerevisiae, in early meiotic prophase, centromeres are observed to associate in pairs in a homology-..
  48. Portela R, Vogl T, Kniely C, Fischer J, Oliveira R, Glieder A. Synthetic Core Promoters as Universal Parts for Fine-Tuning Expression in Different Yeast Species. ACS Synth Biol. 2017;6:471-484 pubmed publisher
    ..pastoris and three in Saccharomyces cerevisiae)...
  49. Ko J, Lee S. Advances in cellulosic conversion to fuels: engineering yeasts for cellulosic bioethanol and biodiesel production. Curr Opin Biotechnol. 2017;50:72-80 pubmed publisher
    ..This review highlights recent trends in the metabolic engineering of microbial platforms, such as the industrial yeasts Saccharomyces cerevisiae and Yarrowia lipolytica, for the production of renewable fuels.
  50. Kim S, Na J, Hampsey M, Reinberg D. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc Natl Acad Sci U S A. 1997;94:820-5 pubmed
    ..To elucidate the function of Dr1 and DRAP1 in vivo, the yeast Saccharomyces cerevisiae Dr1/DRAP1 repressor complex was identified...
  51. Stevens H, Malone L, Nichols J. The putative aminophospholipid translocases, DNF1 and DNF2, are not required for 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine flip across the plasma membrane of Saccharomyces cerevisiae. J Biol Chem. 2008;283:35060-9 pubmed publisher
    ....
  52. Beato F, Bergdahl B, Rosa C, Forster J, Gombert A. Physiology of Saccharomyces cerevisiae strains isolated from Brazilian biomes: new insights into biodiversity and industrial applications. FEMS Yeast Res. 2016;16: pubmed
    Fourteen indigenous Saccharomyces cerevisiae strains isolated from the barks of three tree species located in the Atlantic Rain Forest and Cerrado biomes in Brazil were genetically and physiologically compared to laboratory strains and ..
  53. Janas E, Hofacker M, Chen M, Gompf S, van der Does C, Tampe R. The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p. J Biol Chem. 2003;278:26862-9 pubmed
    ..processing (TAP) plays an important role in intracellular peptide transport from the mitochondrial matrix of Saccharomyces cerevisiae...
  54. Srikanth C, Chakraborti A, Bachhawat A. Acetaminophen toxicity and resistance in the yeast Saccharomyces cerevisiae. Microbiology. 2005;151:99-111 pubmed
    ..In contrast, resistance mediated by Pdr1p/Pdr3p did not require a functional Yap1p, and revealed a distinct hierarchy in the resistance to acetaminophen...
  55. Castanys Muñoz E, Alder Baerens N, Pomorski T, Gamarro F, Castanys S. A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids. Mol Microbiol. 2007;64:1141-53 pubmed
    ..Likewise, when expressed in Saccharomyces cerevisiae, the protein localized to the yeast plasma membrane and conferred resistance to alkyl-phospholipids...
  56. Baker A, Carrier D, Schaedler T, Waterham H, Van Roermund C, Theodoulou F. Peroxisomal ABC transporters: functions and mechanism. Biochem Soc Trans. 2015;43:959-65 pubmed publisher
    ..are half transporters that homodimerize and have distinct but partially overlapping substrate specificity; Saccharomyces cerevisiae has two half transporters that heterodimerize and plants have a single peroxisomal ABC transporter ..
  57. Guo Z, Olsson L. Physiological responses to acid stress by Saccharomyces cerevisiae when applying high initial cell density. FEMS Yeast Res. 2016;16: pubmed
    ..Comparison of physiological parameters in high initial cell density cultivation of Saccharomyces cerevisiae in the presence of acetic, formic, levulinic and cinnamic acids demonstrated general and acid-..
  58. Shekhar Guturja T, Tebung W, Mount H, Liu N, Köhler J, Whiteway M, et al. Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29. Antimicrob Agents Chemother. 2016;60:7468-7480 pubmed
    ..As observed in Saccharomyces cerevisiae, we determined that beauvericin inhibits TOR signaling in Candida albicans To further characterize ..
  59. Kliewe F, Kumme J, Grigat M, Hintze S, Schüller H. Opi1 mediates repression of phospholipid biosynthesis by phosphate limitation in the yeast Saccharomyces cerevisiae. Yeast. 2017;34:67-81 pubmed publisher
    Structural genes of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae are transcribed when precursor molecules inositol and choline (IC) are limiting...
  60. Thouvenot P, Fourrière L, Dardillac E, Ben Yamin B, Lescure A, Lejour V, et al. Yeast cells reveal the misfolding and the cellular mislocalization of the human BRCA1 protein. J Cell Sci. 2016;129:4366-4378 pubmed
    ..The yeast Saccharomyces cerevisiae model has held attention for its capacity to monitor the functional impact of missense mutations ..
  61. Chernova T, Kiktev D, Romanyuk A, Shanks J, Laur O, Ali M, et al. Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress. Cell Rep. 2017;18:751-761 pubmed publisher
    ..by Lsb2 is traced to a single amino acid change, coinciding with the acquisition of thermotolerance in the Saccharomyces yeast lineage...
  62. Park Y, Kim T, Yun C. Functional characterization of the copper transcription factor AfMac1 from Aspergillus fumigatus. Biochem J. 2017;474:2365-2378 pubmed publisher
    ..fumigatus AfMac1 has domains homologous to the DNA-binding and copper-binding domains of Mac1 from Saccharomyces cerevisiae, and AfMac1 efficiently complemented Mac1 in S...
  63. Vu P, Unpaprom Y, Ramaraj R. Impact and significance of alkaline-oxidant pretreatment on the enzymatic digestibility of Sphenoclea zeylanica for bioethanol production. Bioresour Technol. 2017;247:125-130 pubmed publisher
    ..at 50°C for 24-72h with enzyme cellulase (β-glucosidase) while the fermentation process was carried using Saccharomyces cerevisiae TISTR 5020 at 33°C for nine days...
  64. Takeda E, Jin N, Itakura E, Kira S, Kamada Y, Weisman L, et al. Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress. Mol Biol Cell. 2017;: pubmed publisher
    ..In the budding yeast, Saccharomyces cerevisiae, TORC1 senses nitrogen and various stressors, and modulates proteosynthesis, nitrogen uptake ..
  65. Fuellen G, Spitzer M, Cullen P, Lorkowski S. Correspondence of function and phylogeny of ABC proteins based on an automated analysis of 20 model protein data sets. Proteins. 2005;61:888-99 pubmed
    ..All but 11 sequences from Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, and Saccharomyces cerevisiae were placed into the correct subtree/subfamily, reproducing published classifications of the ..
  66. Khakhina S, Johnson S, Manoharlal R, Russo S, Blugeon C, Lemoine S, et al. Control of Plasma Membrane Permeability by ABC Transporters. Eukaryot Cell. 2015;14:442-53 pubmed publisher
    ATP-binding cassette transporters Pdr5 and Yor1 from Saccharomyces cerevisiae control the asymmetric distribution of phospholipids across the plasma membrane as well as serving as ATP-dependent drug efflux pumps...
  67. Sáez Jiménez V, Acebes S, García Ruiz E, Romero A, Guallar V, Alcalde M, et al. Unveiling the basis of alkaline stability of an evolved versatile peroxidase. Biochem J. 2016;473:1917-28 pubmed publisher
    ..2-1B) was obtained by directed evolution of the Pleurotus eryngii VP (versatile peroxidase) expressed in Saccharomyces cerevisiae [García-Ruiz, González-Pérez, Ruiz-Dueñas, Martínez and Alcalde (2012) Biochem. J...
  68. Ianiri G, Boyce K, Idnurm A. Isolation of conditional mutations in genes essential for viability of Cryptococcus neoformans. Curr Genet. 2017;63:519-530 pubmed publisher
    ..in the homologs of IDI1, MRPL37, NOC3, NOP56, PRE3 and RPL17, all of which are essential in ascomycete yeasts Saccharomyces cerevisiae or Schizosaccharomyces pombe...
  69. Goldstein E, Johnson S, Maziade P, Evans C, Sniffen J, Millette M, et al. Probiotics and prevention of Clostridium difficile infection. Anaerobe. 2017;45:114-119 pubmed publisher
    ..of action, the value and cost effectiveness of probiotics are addressed with a focus on three agents, Saccharomyces boulardii, Lactobacillus rhamnosus GG and the combination of Lactobacillus acidophilus CL1285, Lactobacillus ..
  70. Ghosal A, Köhrer C, Babu V, Yamanaka K, Davies B, Jacob A, et al. C21orf57 is a human homologue of bacterial YbeY proteins. Biochem Biophys Res Commun. 2017;484:612-617 pubmed publisher
    ..Expression of HuYbeY in Saccharomyces cerevisiae, which lacks a YbeY homologue, results in a severe growth phenotype...
  71. Santas J, Lazaro E, Cuñé J. Effect of a polysaccharide-rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double-blind, placebo-controlled clinical trial in overweight and obese adults. J Sci Food Agric. 2017;97:4250-4257 pubmed publisher
    ..of a polysaccharide-rich food supplement, LipiGo®, comprising a specific β-glucan-chitin-chitosan fraction (BGCC) obtained from the chemical hydrolysis of Saccharomyces cerevisiae, resulting as a by-product of the brewing process.
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    ..accumulation/pausing of RNA polymerase II (Pol II) independently of its capping activity in Saccharomyces cerevisiae to control transcription. However, it is still unknown how Pol II pausing is regulated by Cet1...
  73. Lawrence M, Coutin N, Choi J, Martin B, Irwin N, Young B, et al. Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae. Genetics. 2017;207:347-355 pubmed publisher
    ..of genetic and genomic approaches to explore the regulation of linker histone binding in the yeast, Saccharomyces cerevisiae We found that increased expression of Hho1, the yeast linker histone, resulted in a severe ..
  74. Zacchi L, Dittmar J, Mihalevic M, Shewan A, Schulz B, Brodsky J, et al. Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE. Dis Model Mech. 2017;10:1129-1140 pubmed publisher
    ..protein levels, we designed a new high-throughput, automated, genome-wide screen utilizing our validated Saccharomyces cerevisiae torsinA expression system...
  75. Rong Mullins X, Winans M, Lee J, Lonergan Z, Pilolli V, Weatherly L, et al. Proteomic and genetic analysis of the response of S. cerevisiae to soluble copper leads to improvement of the antimicrobial function of cellulosic copper nanoparticles. Metallomics. 2017;9:1304-1315 pubmed publisher
    ..We challenged strains of Saccharomyces cerevisiae with soluble Cu and c-CuNPs to evaluate the potential of c-CuNPs as antifungal agents...
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    The Asc1 protein of Saccharomyces cerevisiae is a scaffold protein at the head region of ribosomal 40S that links mRNA translation to cellular signaling...
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    ..Pyrosequencing results showed that the most common genera were Malassezia (44%), followed by Candida (19%) and Saccharomyces (12%). Yeast cells were observed by fluorescence microscopy...
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    STE6 gene product is required for secretion of the lipopeptide mating pheromone a-factor by Saccharomyces cerevisiae MATa cells...
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    ..polymerase chain reaction to amplify 10 DNA fragments homologous to members of the ABC family from the yeast Saccharomyces cerevisiae...
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    Hcs77 is a putative cell surface sensor for cell integrity signaling in Saccharomyces cerevisiae. Its loss of function results in cell lysis during growth at elevated temperatures (e.g...
  82. St Georgiev V. Membrane transporters and antifungal drug resistance. Curr Drug Targets. 2000;1:261-84 pubmed
    ..overexpression of multidrug efflux transporter genes, significant advances have been achieved primarily with Saccharomyces cerevisiae and Candida albicans...
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    ..Although in Saccharomyces cerevisiae GIN4-related kinases influence septin ring organization and septin rings influence the localization ..
  84. Kolaczkowska A, Kolaczkowski M, Goffeau A, Moye Rowley W. Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae. FEBS Lett. 2008;582:977-83 pubmed publisher
    In Saccharomyces cerevisiae, the transcription factors Pdr1p and Pdr3p activate the expression of several genes, including PDR5, SNQ2, and YOR1, which encode ATP-binding cassette transporters that extrude dozens of antifungals with ..
  85. Krasowska A, Łukaszewicz M, Bartosiewicz D, Sigler K. Cell ATP level of Saccharomyces cerevisiae sensitively responds to culture growth and drug-inflicted variations in membrane integrity and PDR pump activity. Biochem Biophys Res Commun. 2010;395:51-5 pubmed publisher
    Cellular ATP level in Saccharomyces cerevisiae was measured during culture growth of strain US50-18C overproducing all major PDR pumps and its isogenic mutants variously deleted in these pumps...
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    ..To unravel the mechanism of peroxisomal VLCFA transport, we use Saccharomyces cerevisiae as a model organism...
  87. Paul S, Bair T, Moye Rowley W. Identification of genomic binding sites for Candida glabrata Pdr1 transcription factor in wild-type and ρ0 cells. Antimicrob Agents Chemother. 2014;58:6904-12 pubmed publisher
    ..These genes include many that are shared with the yeast Saccharomyces cerevisiae but others that are unique to C...
  88. Huang D, Piening B, Kennedy J, Lin C, Jones Weinert C, Yan P, et al. DNA Replication Stress Phosphoproteome Profiles Reveal Novel Functional Phosphorylation Sites on Xrs2 in Saccharomyces cerevisiae. Genetics. 2016;203:353-68 pubmed publisher
    ..In particular, we identified MMS-induced phosphorylation sites on Xrs2 that are required for MMS resistance in the absence of the MRX activator, Sae2, and that affect telomere maintenance...
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    Sirtuins are a family of protein deacylases related by amino acid sequence and cellular function to the yeast Saccharomyces cerevisiae protein Sir2 (Silent Information Regulator-2), the first of this class of enzymes to be identified and ..
  90. Kirby J, Dietzel K, Wichmann G, Chan R, Antipov E, Moss N, et al. Engineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in Saccharomyces cerevisiae. Metab Eng. 2016;38:494-503 pubmed publisher
    ..b>Saccharomyces cerevisiae exclusively utilizes the mevalonate pathway to synthesize native isoprenoids and in fact the ..
  91. Konikkat S, Woolford J. Principles of 60S ribosomal subunit assembly emerging from recent studies in yeast. Biochem J. 2017;474:195-214 pubmed publisher
    ..assembly that have emerged from recent studies of biogenesis of the large ribosomal subunit in the yeast Saccharomyces cerevisiae We describe tools that have empowered investigations of ribosome biogenesis, and then summarize ..
  92. Kramer M, Farre J, Mitra K, Yu M, Ono K, Demchak B, et al. Active Interaction Mapping Reveals the Hierarchical Organization of Autophagy. Mol Cell. 2017;65:761-774.e5 pubmed publisher
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    To identify cellular conditions that significantly alter susceptibility of Saccharomyces cerevisiae, Candida albicans and Candida glabrata to the antimicrobial peptide, occidiofungin.
  94. Belda I, Ruiz J, Beisert B, Navascués E, Marquina D, Calderon F, et al. Influence of Torulaspora delbrueckii in varietal thiol (3-SH and 4-MSP) release in wine sequential fermentations. Int J Food Microbiol. 2017;257:183-191 pubmed publisher
    In last years, non-Saccharomyces yeasts have emerged as innovative tools to improve wine quality, being able to modify the concentration of sensory-impact compounds...
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    ..The yeast Saccharomyces cerevisiae Isw1 partners with several non-essential alternative subunits - Ioc2, Ioc3, or Ioc4 - to form ..
  96. Alonso Del Real J, Contreras Ruiz A, Castiglioni G, Barrio E, Querol A. The Use of Mixed Populations of Saccharomyces cerevisiae and S. kudriavzevii to Reduce Ethanol Content in Wine: Limited Aeration, Inoculum Proportions, and Sequential Inoculation. Front Microbiol. 2017;8:2087 pubmed publisher
    i>Saccharomyces cerevisiae is the most widespread microorganism responsible for wine alcoholic fermentation...
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    ..In face of these results we raised the hypothesis that Cd-GS(2) complex controls cadmium uptake through the Zrt1 protein...
  98. Hiraga K, Yamamoto S, Fukuda H, Hamanaka N, Oda K. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2005;328:1119-25 pubmed
    Pdr5p is one of the major multidrug efflux pumps whose overexpression confers multidrug resistance (MDR) in Saccharomyces cerevisiae...
  99. Tsujimoto Y, Shimizu Y, Otake K, Nakamura T, Okada R, Miyazaki T, et al. Multidrug resistance transporters Snq2p and Pdr5p mediate caffeine efflux in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2015;79:1103-10 pubmed publisher
    SNQ2 was identified as a caffeine-resistance gene by screening a genomic library of Saccharomyces cerevisiae in a multicopy vector YEp24. SNQ2 encodes an ATP-binding cassette transporter and is highly homologous to PDR5...
  100. Young J, Marcotte E. Predictability of Genetic Interactions from Functional Gene Modules. G3 (Bethesda). 2017;7:617-624 pubmed publisher
    ..approach to predict genetic interactions in Homo sapiens, Drosophila melanogaster, and Saccharomyces cerevisiae By leveraging knowledge of functional relationships between genes, we cross-validate ..
  101. Bui D, Friedrich A, Al Sweel N, Liti G, Schacherer J, Aquadro C, et al. Mismatch Repair Incompatibilities in Diverse Yeast Populations. Genetics. 2017;205:1459-1471 pubmed publisher
    ..involving naturally occurring variants in the MLH1 and PMS1 mismatch repair (MMR) genes of Saccharomyces cerevisiae We hypothesized that this MMR incompatibility, created through mating between divergent S...