Yersinia pestis

Summary

Alias: "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900, "Bacterium pestis" Lehmann and Neumann 1896, "Pasteurella pestis" (Lehmann and Neumann 1896) Bergey et al. 1923, "Pestisella pestis" (Lehmann and Neumann 1896) Dorofeev 1947, Bacillus pestis, Bacterium pestis, Pasteurella pestis, Pestisella pestis, Yersinia pestis (Lehmann and Neumann 1896) van Loghem 1944 (Approved Lists 1980), nom. cons, Yersinia pseudotuberculosis subsp. pestis, Yersinia pseudotuberculosis subsp. pestis (Lehmann and Neumann 1896) Bercovier et al. 1981

Top Publications

  1. Dewoody R, Merritt P, Marketon M. YopK controls both rate and fidelity of Yop translocation. Mol Microbiol. 2013;87:301-17 pubmed publisher
    b>Yersinia pestis, the causative agent of plague, utilizes a type III secretion system (T3SS) to intoxicate host cells...
  2. Lilo S, Zheng Y, Bliska J. Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ. Infect Immun. 2008;76:3911-23 pubmed publisher
    ..Naïve murine macrophages were infected with a panel of different Yersinia pestis and Yersinia pseudotuberculosis strains to determine whether Yops of these species inhibit caspase-1 ..
  3. Seecharran T, Kalin Manttari L, Koskela K, Nikkari S, Dickins B, Corander J, et al. Phylogeographic separation and formation of sexually discrete lineages in a global population of Yersinia pseudotuberculosis. Microb Genom. 2017;3:e000133 pubmed publisher
    ..genomic studies have been performed on the other human pathogenic species of the genus Yersinia, Yersinia pestis and Yersinia enterocolitica allowing a high-resolution understanding of the ecology, evolution and ..
  4. Zapata Valdés C, Ávila Flores R, Gage K, Holmes J, Montenierri J, Kosoy M, et al. Mammalian Hosts, Vectors, and Bacterial Pathogens in Communities with and without Black-Tailed Prairie Dogs (Cynomys ludovicianus) in Northwestern Mexico. J Wildl Dis. 2017;: pubmed publisher
    ..of small mammals; 2) the prevalence, abundance, and intensity of arthropod vectors; and 3) the prevalence of Yersinia pestis, Francisella tularensis, and Bartonella spp...
  5. Fan Y, Zhou Y, Feng N, Wang Q, Tian G, Wu X, et al. Recombinant murine toxin from Yersinia pestis shows high toxicity and β-adrenergic blocking activity in mice. Microbes Infect. 2016;18:329-35 pubmed publisher
    b>Yersinia pestis murine toxin (Ymt) encoded on pMT1 is a 61-kDa protein, a member of the phospholipase D superfamily, which is found in all the domains of life...
  6. Zhang Y, Luo T, Yang C, Yue X, Guo R, Wang X, et al. Phenotypic and Molecular Genetic Characteristics of Yersinia pestis at an Emerging Natural Plague Focus, Junggar Basin, China. Am J Trop Med Hyg. 2017;: pubmed publisher
    ..To characterize the phenotypic and genetic diversity of the Yersinia pestis population in this newly established focus, we collected 25 Y...
  7. Salkeld D. Vaccines for Conservation: Plague, Prairie Dogs & Black-Footed Ferrets as a Case Study. Ecohealth. 2017;14:432-437 pubmed publisher
    The endangered black-footed ferret (Mustela nigripes) is affected by plague, caused by Yersinia pestis, both directly, as a cause of mortality, and indirectly, because of the impacts of plague on its prairie dog (Cynomys spp.) prey base...
  8. Hoffman J, Sullivan S, Wu E, Wilson E, Erickson D. Differential impact of lipopolysaccharide defects caused by loss of RfaH in Yersinia pseudotuberculosis and Yersinia pestis. Sci Rep. 2017;7:10915 pubmed publisher
    ..Despite enhanced sensitivity to host defense peptides, the Y. pseudotuberculosis ΔrfaH strain was not attenuated in mice, suggesting that rfaH is not required for acute infection. ..
  9. Rocke T, Tripp D, Russell R, Abbott R, Richgels K, Matchett M, et al. Sylvatic Plague Vaccine Partially Protects Prairie Dogs (Cynomys spp.) in Field Trials. Ecohealth. 2017;14:438-450 pubmed publisher
    Sylvatic plague, caused by Yersinia pestis, frequently afflicts prairie dogs (Cynomys spp.), causing population declines and local extirpations...
  10. Vogler A, Nottingham R, Busch J, Sahl J, Shuey M, Foster J, et al. VNTR diversity in Yersinia pestis isolates from an animal challenge study reveals the potential for in vitro mutations during laboratory cultivation. Infect Genet Evol. 2016;45:297-302 pubmed publisher
    ..Here, we investigated tissue samples and Yersinia pestis isolates from a rodent laboratory challenge with strain CO92 using whole genome sequencing and multi-locus ..

Detail Information

Publications65

  1. Dewoody R, Merritt P, Marketon M. YopK controls both rate and fidelity of Yop translocation. Mol Microbiol. 2013;87:301-17 pubmed publisher
    b>Yersinia pestis, the causative agent of plague, utilizes a type III secretion system (T3SS) to intoxicate host cells...
  2. Lilo S, Zheng Y, Bliska J. Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ. Infect Immun. 2008;76:3911-23 pubmed publisher
    ..Naïve murine macrophages were infected with a panel of different Yersinia pestis and Yersinia pseudotuberculosis strains to determine whether Yops of these species inhibit caspase-1 ..
  3. Seecharran T, Kalin Manttari L, Koskela K, Nikkari S, Dickins B, Corander J, et al. Phylogeographic separation and formation of sexually discrete lineages in a global population of Yersinia pseudotuberculosis. Microb Genom. 2017;3:e000133 pubmed publisher
    ..genomic studies have been performed on the other human pathogenic species of the genus Yersinia, Yersinia pestis and Yersinia enterocolitica allowing a high-resolution understanding of the ecology, evolution and ..
  4. Zapata Valdés C, Ávila Flores R, Gage K, Holmes J, Montenierri J, Kosoy M, et al. Mammalian Hosts, Vectors, and Bacterial Pathogens in Communities with and without Black-Tailed Prairie Dogs (Cynomys ludovicianus) in Northwestern Mexico. J Wildl Dis. 2017;: pubmed publisher
    ..of small mammals; 2) the prevalence, abundance, and intensity of arthropod vectors; and 3) the prevalence of Yersinia pestis, Francisella tularensis, and Bartonella spp...
  5. Fan Y, Zhou Y, Feng N, Wang Q, Tian G, Wu X, et al. Recombinant murine toxin from Yersinia pestis shows high toxicity and β-adrenergic blocking activity in mice. Microbes Infect. 2016;18:329-35 pubmed publisher
    b>Yersinia pestis murine toxin (Ymt) encoded on pMT1 is a 61-kDa protein, a member of the phospholipase D superfamily, which is found in all the domains of life...
  6. Zhang Y, Luo T, Yang C, Yue X, Guo R, Wang X, et al. Phenotypic and Molecular Genetic Characteristics of Yersinia pestis at an Emerging Natural Plague Focus, Junggar Basin, China. Am J Trop Med Hyg. 2017;: pubmed publisher
    ..To characterize the phenotypic and genetic diversity of the Yersinia pestis population in this newly established focus, we collected 25 Y...
  7. Salkeld D. Vaccines for Conservation: Plague, Prairie Dogs & Black-Footed Ferrets as a Case Study. Ecohealth. 2017;14:432-437 pubmed publisher
    The endangered black-footed ferret (Mustela nigripes) is affected by plague, caused by Yersinia pestis, both directly, as a cause of mortality, and indirectly, because of the impacts of plague on its prairie dog (Cynomys spp.) prey base...
  8. Hoffman J, Sullivan S, Wu E, Wilson E, Erickson D. Differential impact of lipopolysaccharide defects caused by loss of RfaH in Yersinia pseudotuberculosis and Yersinia pestis. Sci Rep. 2017;7:10915 pubmed publisher
    ..Despite enhanced sensitivity to host defense peptides, the Y. pseudotuberculosis ΔrfaH strain was not attenuated in mice, suggesting that rfaH is not required for acute infection. ..
  9. Rocke T, Tripp D, Russell R, Abbott R, Richgels K, Matchett M, et al. Sylvatic Plague Vaccine Partially Protects Prairie Dogs (Cynomys spp.) in Field Trials. Ecohealth. 2017;14:438-450 pubmed publisher
    Sylvatic plague, caused by Yersinia pestis, frequently afflicts prairie dogs (Cynomys spp.), causing population declines and local extirpations...
  10. Vogler A, Nottingham R, Busch J, Sahl J, Shuey M, Foster J, et al. VNTR diversity in Yersinia pestis isolates from an animal challenge study reveals the potential for in vitro mutations during laboratory cultivation. Infect Genet Evol. 2016;45:297-302 pubmed publisher
    ..Here, we investigated tissue samples and Yersinia pestis isolates from a rodent laboratory challenge with strain CO92 using whole genome sequencing and multi-locus ..
  11. Hinnebusch B, Chouikha I, Sun Y. Ecological Opportunity, Evolution, and the Emergence of Flea-Borne Plague. Infect Immun. 2016;84:1932-40 pubmed publisher
    The plague bacillus Yersinia pestis is unique among the pathogenic Enterobacteriaceae in utilizing an arthropod-borne transmission route. Transmission by fleabite is a recent evolutionary adaptation that followed the divergence of Y...
  12. Kumar R, Qi Y, Matsumura H, Lovell S, Yao H, Battaile K, et al. Replacing Arginine 33 for Alanine in the Hemophore HasA from Pseudomonas aeruginosa Causes Closure of the H32 Loop in the Apo-Protein. Biochemistry. 2016;55:2622-31 pubmed publisher
    Previous characterization of hemophores from Serratia marcescens (HasAs), Pseudomonas aeruginosa (HasAp), and Yersinia pestis (HasAyp) showed that hemin binds between two loops, where it is axially coordinated by H32 and Y75...
  13. Sebbane F, Jarrett C, Gardner D, Long D, Hinnebusch B. The Yersinia pestis caf1M1A1 fimbrial capsule operon promotes transmission by flea bite in a mouse model of bubonic plague. Infect Immun. 2009;77:1222-9 pubmed publisher
    Plague is a zoonosis transmitted by fleas and caused by the gram-negative bacterium Yersinia pestis. During infection, the plasmidic caf1M1A1 operon that encodes the Y...
  14. Vitagliano L, Ruggiero A, Pedone C, Berisio R. Conformational states and association mechanism of Yersinia pestis Caf1 subunits. Biochem Biophys Res Commun. 2008;372:804-10 pubmed publisher
    ..Here, we report molecular dynamics characterizations of Yersinia pestis Caf1 subunit in its monomeric-unbound and dimeric states...
  15. Shao F, Merritt P, Bao Z, Innes R, Dixon J. A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell. 2002;109:575-88 pubmed
    ..These findings provide new insights into mechanisms of animal and plant pathogenesis...
  16. Musson J, Morton M, Walker N, Harper H, McNeill H, Williamson E, et al. Sequential proteolytic processing of the capsular Caf1 antigen of Yersinia pestis for major histocompatibility complex class II-restricted presentation to T lymphocytes. J Biol Chem. 2006;281:26129-35 pubmed publisher
    We studied the mechanisms of antigen presentation of CD4 T cell epitopes of the capsular Caf1 antigen of Yersinia pestis using murine bone marrow macrophages as antigen presenting cells and T cell hybridomas specific for major ..
  17. Feng N, Zhou Y, Fan Y, Bi Y, Yang R, Zhou Y, et al. Yersinia pestis detection by loop-mediated isothermal amplification combined with magnetic bead capture of DNA. Braz J Microbiol. 2018;49:128-137 pubmed publisher
    ..LAMP has a higher sensitivity than PCR, and magnetic bead capture of DNAs could remarkably increase the sensitivity of LAMP. LAMP is a simple, rapid and sensitive assay suitable for application in the field or poverty areas. ..
  18. Boegler K, Atiku L, Enscore R, Apangu T, Mpanga J, Acayo S, et al. Rat Fall Surveillance Coupled with Vector Control and Community Education as a Plague Prevention Strategy in the West Nile Region, Uganda. Am J Trop Med Hyg. 2017;: pubmed publisher
    ..from 142 villages reported 580 small mammal deaths; 24 of these tested presumptive positive for Yersinia pestis by fluorescence microscopy...
  19. Uittenbogaard A, Chelvarajan R, Myers Morales T, Gorman A, Brickey W, Ye Z, et al. Toward a molecular pathogenic pathway for Yersinia pestis YopM. Front Cell Infect Microbiol. 2012;2:155 pubmed publisher
    ..These studies revealed novel early transcriptional effects of YopM but point to a time after 18 h of infection when critical transitional events lead to later major effects on cytokine gene transcription...
  20. Mega W, Doyle Eisele M, Cass R, Kostrub C, Sherwood R, Metz M, et al. Plazomicin is effective in a non-human primate pneumonic plague model. Bioorg Med Chem. 2016;24:6429-6439 pubmed publisher
    ..African Green monkeys challenged with a lethal aerosol of Yersinia pestis [median (range) of 98 (15-331) LD50s] received placebo (n=12) or 'humanized' dose regimens (6...
  21. Day J, Plano G. The Yersinia pestis YscY protein directly binds YscX, a secreted component of the type III secretion machinery. J Bacteriol. 2000;182:1834-43 pubmed
    ..b>Yersinia pestis mutants defective for production of YscX or YscY were unable to export the Yops and V antigen...
  22. Yang R. Plague: Recognition, Treatment, and Prevention. J Clin Microbiol. 2018;56: pubmed publisher
    Plague is caused by Yersinia pestis and is not commonly encountered in clinics, although natural plague foci are widely distributed around the world. Y. pestis has been listed as a category A bioterrorism agent...
  23. Sanapala S, Rahav H, Patel H, Sun W, Curtiss R. Multiple antigens of Yersinia pestis delivered by live recombinant attenuated Salmonella vaccine strains elicit protective immunity against plague. Vaccine. 2016;34:2410-2416 pubmed publisher
    ..we optimized the recombinant attenuated Salmonella typhimurium vaccine (RASV) χ12094 to deliver multiple Yersinia pestis antigens...
  24. Frey S, Lottenbach K, Graham I, Anderson E, Bajwa K, May R, et al. A phase I safety and immunogenicity dose escalation trial of plague vaccine, Flagellin/F1/V, in healthy adult volunteers (DMID 08-0066). Vaccine. 2017;35:6759-6765 pubmed publisher
    Intentional aerosolization of Yersinia pestis may result in pneumonic plague which is highly fatal if not treated early.
  25. Richgels K, Russell R, Bron G, Rocke T. Evaluation of Yersinia pestis Transmission Pathways for Sylvatic Plague in Prairie Dog Populations in the Western U.S. Ecohealth. 2016;13:415-27 pubmed publisher
    Sylvatic plague, caused by the bacterium Yersinia pestis, is periodically responsible for large die-offs in rodent populations that can spillover and cause human mortalities...
  26. Zavialov A, Knight S. A novel self-capping mechanism controls aggregation of periplasmic chaperone Caf1M. Mol Microbiol. 2007;64:153-64 pubmed publisher
    ..It assists in folding and transport of Caf1 subunits of the F1 capsular antigen of Yersinia pestis, the microbe causing bubonic plague...
  27. Dhariwala M, Olson R, Anderson D. Induction of Type I Interferon through a Noncanonical Toll-Like Receptor 7 Pathway during Yersinia pestis Infection. Infect Immun. 2017;85: pubmed publisher
    i>Yersinia pestis causes bubonic, pneumonic, and septicemic plague, diseases that are rapidly lethal to most mammals, including humans...
  28. McDonough K, Hare J. Homology with a repeated Yersinia pestis DNA sequence IS100 correlates with pesticin sensitivity in Yersinia pseudotuberculosis. J Bacteriol. 1997;179:2081-5 pubmed
    ..We propose that IS100 serves as a molecular marker that identifies a subset of Y. pseudotuberculosis isolates that have a particularly close evolutionary and/or ecological relationship with Y. pestis...
  29. Andrades Valtueña A, Mittnik A, Key F, Haak W, Allmäe R, Belinskij A, et al. The Stone Age Plague and Its Persistence in Eurasia. Curr Biol. 2017;: pubmed publisher
    b>Yersinia pestis, the etiologic agent of plague, is a bacterium associated with wild rodents and their fleas...
  30. Abbott R, Russell R, Richgels K, Tripp D, Matchett M, Biggins D, et al. Factors Influencing Uptake of Sylvatic Plague Vaccine Baits by Prairie Dogs. Ecohealth. 2017;: pubmed publisher
    Sylvatic plague vaccine (SPV) is a virally vectored bait-delivered vaccine expressing Yersinia pestis antigens that can protect prairie dogs (Cynomys spp.) from plague and has potential utility as a management tool...
  31. Day J, Plano G. A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis. Mol Microbiol. 1998;30:777-88 pubmed
    ..we characterize the role of the tyeA, sycN and yscB gene products in the regulation of Yop secretion in Yersinia pestis. Mutants specifically defective in the expression of TyeA, SycN or YscB were no longer able to block Yop ..
  32. Peters K, Dhariwala M, Hughes Hanks J, Brown C, Anderson D. Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague. PLoS Pathog. 2013;9:e1003324 pubmed publisher
    b>Yersinia pestis causes pneumonic plague, a disease characterized by inflammation, necrosis and rapid bacterial growth which together cause acute lung congestion and lethality...
  33. Sweet C, Conlon J, Golenbock D, Goguen J, Silverman N. YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction. Cell Microbiol. 2007;9:2700-15 pubmed publisher
    The Yersinia pestis virulence factor YopJ is a potent inhibitor of the NF-kappaB and MAPK signalling pathways, however, its molecular mechanism and relevance to pathogenesis are the subject of much debate...
  34. Dong X, Lindler L, Chu M. Complete DNA sequence and analysis of an emerging cryptic plasmid isolated from Yersinia pestis. Plasmid. 2000;43:144-8 pubmed publisher
    A 6-kb cryptic plasmid (pYC; 5919 bp) has been recovered from Yersinia pestis isolates originating from regions of Yunnan province in China...
  35. Leal E, Moreira J, Nunes F, Souza L, Martins J, Toledo V, et al. Humoral and cellular immune response of mice challenged with Yersinia pestis antigenic preparations. Braz J Infect Dis. 2017;21:620-626 pubmed publisher
    The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries...
  36. Wolkowicz T. The utility and perspectives of NGS-based methods in BSL-3 and BSL-4 laboratory - sequencing and analysis strategies. Brief Funct Genomics. 2017;: pubmed publisher
    ..into routine diagnostic of highly dangerous pathogens, like Bacillus anthracis, Francisella tularensis, Yersinia pestis, Ebola virus, MERS, Lassa virus etc. would be very helpful...
  37. Hinnebusch B, Jarrett C, Bland D. "Fleaing" the Plague: Adaptations of Yersinia pestis to Its Insect Vector That Lead to Transmission. Annu Rev Microbiol. 2017;71:215-232 pubmed publisher
    ..b>Yersinia pestis adopts a unique life stage in the digestive tract of its flea vector, characterized by rapid formation of a ..
  38. Dutta S, Yao Y, Marassi F. Structural Insights into the Yersinia pestis Outer Membrane Protein Ail in Lipid Bilayers. J Phys Chem B. 2017;121:7561-7570 pubmed publisher
    b>Yersinia pestis the causative agent of plague, is highly pathogenic and poses very high risk to public health. The outer membrane protein Ail (Adhesion invasion locus) is one of the most highly expressed proteins on the cell surface of Y...
  39. Eroshenko G, Nosov N, Krasnov Y, Oglodin Y, Kukleva L, Guseva N, et al. Yersinia pestis strains of ancient phylogenetic branch 0.ANT are widely spread in the high-mountain plague foci of Kyrgyzstan. PLoS ONE. 2017;12:e0187230 pubmed publisher
    Fifty six Yersinia pestis strains, isolated over the period of more than 50 years in three high-mountain foci of Kyrgyzstan (Tien Shan, Alai, and Talas), have been characterized by means of PCR and single nucleotide polymorphism (SNP) ..
  40. Zhou Y, Zhou J, Ji Y, Li L, Tan Y, Tian G, et al. Bioluminescent tracing of a Yersinia pestis pCD1+-mutant and Yersinia pseudotuberculosis in subcutaneously infected mice. Microbes Infect. 2017;: pubmed publisher
    b>Yersinia pestis has evolved from Y. pseudotuberculosis serotype O:1b. A typical Y. pestis contains three plasmids: pCD1, pMT1 and pPCP1. However, some isolates only harbor pCD1 (pCD1+-mutant). Y. pestis and Y...
  41. Nor M, Richards G, McGloughlin S, Amin P. Pneumonia in the tropics: Report from the Task Force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine. J Crit Care. 2017;: pubmed publisher
    ..of pneumonia including the viral causes such as influenza (seasonal and avian varieties), the coronaviruses and the Hantavirus as well as bacterial causes, specifically the pneumonic form of Yersinia pestis and melioidosis are discussed.
  42. Viitanen A, Toivanen P, Skurnik M. The lcrE gene is part of an operon in the lcr region of Yersinia enterocolitica O:3. J Bacteriol. 1990;172:3152-62 pubmed
    The low-calcium response (lcr) region of the virulence plasmid of Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica has been associated with calcium-dependent growth of bacteria...
  43. Yao Y, Dutta S, Park S, Rai R, Fujimoto L, Bobkov A, et al. High resolution solid-state NMR spectroscopy of the Yersinia pestis outer membrane protein Ail in lipid membranes. J Biomol NMR. 2017;67:179-190 pubmed publisher
    ..membrane protein Ail (Adhesion invasion locus) is one of the most abundant proteins on the cell surface of Yersinia pestis during human infection...
  44. Michiels T, Wattiau P, Brasseur R, Ruysschaert J, Cornelis G. Secretion of Yop proteins by Yersiniae. Infect Immun. 1990;58:2840-9 pubmed
    ..Protein Yop25 is very similar to YopE, the corresponding protein from Yersinia pestis, Y. pseudotuberculosis, and Y. enterocolitica O:8 (A. Forsberg and H. Wolf-Watz, J. Bacteriol...
  45. Achtman M. How old are bacterial pathogens?. Proc Biol Sci. 2016;283: pubmed publisher
    ..of genetic diversity and ancient DNA studies indicate that during the last 5000 years plague caused by Yersinia pestis has spread globally on multiple occasions from China and Central Asia...
  46. Tencati M, Tapping R. Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1. Infect Immun. 2016;84:2904-13 pubmed publisher
    b>Yersinia pestis is a Gram-negative bacterium that is the causative agent of bubonic and pneumonic plague. It is commonly acquired by mammals such as rodents and humans via the bite of an infected flea...
  47. Zhou D, Hardt W, Galan J. Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island. Infect Immun. 1999;67:1974-81 pubmed
    ..open reading frames which encode polypeptides with extensive homology to the yfe ABC iron transport system of Yersinia pestis, as well as other ABC transporters...
  48. Reimmann C, Patel H, Serino L, Barone M, Walsh C, Haas D. Essential PchG-dependent reduction in pyochelin biosynthesis of Pseudomonas aeruginosa. J Bacteriol. 2001;183:813-20 pubmed
    ..PchG is a homolog of the Yersinia pestis and Y. enterocolitica proteins YbtU and Irp3, which are involved in the biosynthesis of yersiniabactin...
  49. Runyen Janecky L, Reeves S, Gonzales E, Payne S. Contribution of the Shigella flexneri Sit, Iuc, and Feo iron acquisition systems to iron acquisition in vitro and in cultured cells. Infect Immun. 2003;71:1919-28 pubmed
    ..flexneri sit locus was homologous to the Salmonella enterica serovar Typhimurium Sit and Yersinia pestis Yfe systems, which mediate both manganese and iron transport. The S...
  50. Benavides Montano J, Vadyvaloo V. Yersinia pestis Resists Predation by Acanthamoeba castellanii and Exhibits Prolonged Intracellular Survival. Appl Environ Microbiol. 2017;83: pubmed publisher
    Plague is a flea-borne rodent-associated zoonotic disease caused by Yersinia pestis The disease is characterized by epizootics with high rodent mortalities, punctuated by interepizootic periods when the bacterium persists in an ..
  51. Straub M, Roy A, Martin A, Sholty K, Stephenson N, Foley J. Distribution and prevalence of vector-borne diseases in California chipmunks (Tamias spp.). PLoS ONE. 2017;12:e0189352 pubmed publisher
    ..Chipmunks host zoonotic pathogens including Yersinia pestis, Anaplasma phagocytophilum, relapsing fever (RF) Borrelia spp...
  52. Mills S, Boland A, Sory M, Van Der Smissen P, Kerbourch C, Finlay B, et al. Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein. Proc Natl Acad Sci U S A. 1997;94:12638-43 pubmed
    ..This indicates possible similarities between the strategies used by pathogenic bacteria to elicit programmed cell death in both plant and animal hosts...
  53. Bearden S, Staggs T, Perry R. An ABC transporter system of Yersinia pestis allows utilization of chelated iron by Escherichia coli SAB11. J Bacteriol. 1998;180:1135-47 pubmed
    The acquisition of iron is an essential component in the pathogenesis of Yersinia pestis, the agent of bubonic and pneumonic plague. A cosmid library derived from the genomic DNA of Y...
  54. Perry R, Mier I, Fetherston J. Roles of the Yfe and Feo transporters of Yersinia pestis in iron uptake and intracellular growth. Biometals. 2007;20:699-703 pubmed
    In Yersinia pestis, the Yfe and Feo systems likely function to transport ferrous iron. Both FeoA and FeoB are essential for iron acquisition activity while FeoC is not...
  55. Andersson J, Sha J, Erova T, Fitts E, Ponnusamy D, Kozlova E, et al. Identification of New Virulence Factors and Vaccine Candidates for Yersinia pestis. Front Cell Infect Microbiol. 2017;7:448 pubmed publisher
    Earlier, we reported the identification of new virulence factors/mechanisms of Yersinia pestis using an in vivo signature-tagged mutagenesis (STM) screening approach...
  56. Edinborough K, Porčić M, Martindale A, Brown T, Supernant K, Ames K. Radiocarbon test for demographic events in written and oral history. Proc Natl Acad Sci U S A. 2017;114:12436-12441 pubmed publisher
    ..using historically derived demographic data from the catastrophic European Black Death/bubonic plague (Yersinia pestis)...
  57. Zheng Y, Lilo S, Mena P, Bliska J. YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense. PLoS ONE. 2012;7:e36019 pubmed publisher
    Yersinia outer protein J (YopJ) is a type III secretion system (T3SS) effector of pathogenic Yersinia (Yersinia pestis, Yersinia enterocolitica and Yersinia pseudotuberculosis) that is secreted into host cells...
  58. Koh E, Hung C, Henderson J. The Yersiniabactin-Associated ATP Binding Cassette Proteins YbtP and YbtQ Enhance Escherichia coli Fitness during High-Titer Cystitis. Infect Immun. 2016;84:1312-9 pubmed publisher
    ..encoding distinctive ATP binding cassette (ABC) proteins associated with iron(III)-yersiniabactin import in Yersinia pestis In this study, we compared the impact of ybtPQ on a model E...
  59. Yang H, Wang T, Tian G, Zhang Q, Wu X, Xin Y, et al. Host transcriptomic responses to pneumonic plague reveal that Yersinia pestis inhibits both the initial adaptive and innate immune responses in mice. Int J Med Microbiol. 2017;307:64-74 pubmed publisher
    Pneumonic plague is the most deadly form of infection caused by Yersinia pestis and can progress extremely fast. However, our understanding on the host transcriptomic response to pneumonic plague is insufficient...
  60. Luhmann N, Doerr D, Chauve C. Comparative scaffolding and gap filling of ancient bacterial genomes applied to two ancient Yersinia pestis genomes. Microb Genom. 2017;3:e000123 pubmed publisher
    i>Yersinia pestis is the causative agent of the bubonic plague, a disease responsible for several dramatic historical pandemics...
  61. Radka C, Chen D, Delucas L, Aller S. The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metal. Acta Crystallogr D Struct Biol. 2017;73:921-939 pubmed publisher
    ..In Yersinia pestis, the causative agent of plague, the Yersinia iron-uptake (Yiu) ABC transporter has been shown to improve iron ..
  62. Rodriguez G, Smith I. Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis. J Bacteriol. 2006;188:424-30 pubmed
    ..genes (irtA and irtB) encoding an ABC transporter similar to the YbtPQ system involved in iron transport in Yersinia pestis. Inactivation of the irtAB system decreases the ability of M...
  63. Rahelinirina S, Rajerison M, Telfer S, Savin C, Carniel E, Duplantier J. The Asian house shrew Suncus murinus as a reservoir and source of human outbreaks of plague in Madagascar. PLoS Negl Trop Dis. 2017;11:e0006072 pubmed publisher
    ..murinus captures during the epidemics, their carriage of the flea vector and their infection with Yersinia pestis suggest they played an important role in the maintenance and transmission of plague. S...
  64. Rudrik J, Soehnlen M, Perry M, Sullivan M, Reiter Kintz W, Lee P, et al. Safety and Accuracy of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Highly Pathogenic Organisms. J Clin Microbiol. 2017;55:3513-3529 pubmed publisher
    ..Forty-six distinct strains of Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, Burkholderia pseudomallei, ..
  65. Qasem Abdullah H, Perach M, Livnat Levanon N, Lewinson O. ATP binding and hydrolysis disrupt the high-affinity interaction between the heme ABC transporter HmuUV and its cognate substrate-binding protein. J Biol Chem. 2017;292:14617-14624 pubmed publisher
    ..Here we studied the interaction between the Yersinia pestis ABC heme importer (HmuUV) and its partner substrate-binding protein (HmuT)...