Genomes and Genes
Alias: zebra danio, zebra fish, Danio rerio, Brachydanio rerio, Brachidanio rerio, leopard danio, Brachydanio rerio frankei, Cyprinus rerio, Cyprinus rerio Hamilton, 1822, Danio frankei, Danio rerio (Hamilton, 1822), Danio rerio frankei
Publications942 found, 100 shown here
- Targeted gene inactivation in zebrafish using engineered zinc-finger nucleasesXiangdong Meng
Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 6th Floor, 364 Plantation St, Worcester, Massachusetts 01605, USA
Nat Biotechnol 26:695-701. 2008..Here we adapt this technology to create targeted mutations in the zebrafish germ line...
- Targeted gene disruption in somatic zebrafish cells using engineered TALENsJeffry D Sander
Nat Biotechnol 29:697-8. 2011
- In vivo imaging of embryonic vascular development using transgenic zebrafishNathan D Lawson
Laboratory of Molecular Genetics, NICHD NIH, Building 6B, 6 Center Drive, Bethesda, MD 20892, USA
Dev Biol 248:307-18. 2002..We find that the zebrafish fli1 promoter is able to drive expression of enhanced green fluorescent protein (EGFP) in all blood vessels ..
- p53 activation by knockdown technologiesMara E Robu
University of Minnesota, Minneapolis, Minnesota, United States of America
PLoS Genet 3:e78. 2007..We have used several model genes to study these effects in detail in the zebrafish, Danio rerio. Using the zebrafish embryo as a template, correct and mistargeting effects are readily discernible through ..
- Genome editing with RNA-guided Cas9 nuclease in zebrafish embryosNannan Chang
Institute of Molecular Medicine, Peking University, Beijing 100871, China
Cell Res 23:465-72. 2013..However, the applicability and efficiency of this system in model organisms, such as zebrafish, are little studied...
- Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genomeTimothy J Dahlem
Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America
PLoS Genet 8:e1002861. 2012The zebrafish is a powerful experimental system for uncovering gene function in vertebrate organisms. Nevertheless, studies in the zebrafish have been limited by the approaches available for eliminating gene function...
- The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructsKristen M Kwan
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, USA
Dev Dyn 236:3088-99. 2007Transgenesis is an important tool for assessing gene function. In zebrafish, transgenesis has suffered from three problems: the labor of building complex expression constructs using conventional subcloning; low transgenesis efficiency, ..
- Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENsLindsay Cade
Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA
Nucleic Acids Res 40:8001-10. 2012..Recent work has shown that TALENs can induce mutations in endogenous zebrafish genes, but to date only four genes have been altered, and larger-scale tests of the success rate, mutation ..
- Haematopoietic stem cells derive directly from aortic endothelium during developmentJulien Y Bertrand
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0380, USA
Nature 464:108-11. 2010..We previously showed that haematopoiesis occurs through four distinct waves during zebrafish development, with HSCs arising in the final wave in close association with the dorsal aorta...
- Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs)Finola E Moore
Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
PLoS ONE 7:e37877. 2012..Effector Nucleases (TALENs) provide robust and user-friendly technologies for efficiently inactivating genes in zebrafish. These designer nucleases bind to and cleave DNA at particular target sites, inducing error-prone repair that ..
- Evaluation and application of modularly assembled zinc-finger nucleases in zebrafishCong Zhu
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
Development 138:4555-64. 2011..we evaluate a straightforward modular assembly-based approach for ZFN construction and gene inactivation in zebrafish. From an archive of 27 different zinc-finger modules, we assembled more than 70 different zinc-finger cassettes ..
- Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancerBaozhi Chen
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Nat Chem Biol 5:100-7. 2009..The signal transduction mechanisms shown here to be chemically tractable additionally contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals...
- Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolismPaul B Yu
Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
Nat Chem Biol 4:33-41. 2008..which we identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish. We found that dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks ..
- Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferationChris Jopling
Center of Regenerative Medicine in Barcelona, Spain
Nature 464:606-9. 2010..contrast to mammals, several non-mammalian vertebrate species are able to regenerate their hearts, including the zebrafish, which can fully regenerate its heart after amputation of up to 20% of the ventricle...
- In vivo genome editing using a high-efficiency TALEN systemVictoria M Bedell
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
Nature 491:114-8. 2012The zebrafish (Danio rerio) is increasingly being used to study basic vertebrate biology and human disease with a rich array of in vivo genetic and molecular tools...
- A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesisMaxence V Nachury
Genentech, Inc, South San Francisco, CA 94080, USA
Cell 129:1201-13. 2007..Conversely, preventing Rab8(GTP) production blocks ciliation in cells and yields characteristic BBS phenotypes in zebrafish. Our data reveal that BBS may be caused by defects in vesicular transport to the cilium.
- MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesisStefania Nicoli
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 464:1196-200. 2010..By using two-photon imaging of live zebrafish embryos, we observe that flow is essential for angiogenesis during AA development...
- A transgenic zebrafish model of neutrophilic inflammationStephen A Renshaw
MRC Centre for Developmental and Biomedical Genetics, Acadamic Unit of Respiratory Medicine, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
Blood 108:3976-8. 2006We have established an in vivo model for genetic analysis of the inflammatory response by generating a transgenic zebrafish line that expresses GFP under the neutrophil-specific myeloperoxidase promoter...
- mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafishFelix Ellett
Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Blood 117:e49-56. 2011..Functional analyses of the cellular innate immune response in zebrafish infection/inflammation models have been aided by transgenic lines with fluorophore-marked neutrophils...
- Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutantsDavid Traver
Children s Hospital Boston and the Howard Hughes Medical Institute, 320 Longwood Avenue, Enders 720, Boston, Massachusetts 02115, USA
Nat Immunol 4:1238-46. 2003The zebrafish is firmly established as a genetic model for the study of vertebrate blood development. Here we have characterized the blood-forming system of adult zebrafish...
- miR-126 regulates angiogenic signaling and vascular integrityJason E Fish
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Dev Cell 15:272-84. 2008..Additionally, knockdown of miR-126 in zebrafish resulted in loss of vascular integrity and hemorrhage during embryonic development...
- Optogenetic dissection of a behavioural module in the vertebrate spinal cordClaire Wyart
Helen Wills Neuroscience Institute and Department of Molecular and Cell Biology, University of California in Berkeley, Berkeley, California 94720, USA
Nature 461:407-10. 2009..CPG that drives spontaneous locomotion using a combination of intersectional gene expression and optogenetics in zebrafish larvae...
- Blood stem cells emerge from aortic endothelium by a novel type of cell transitionKarima Kissa
Institut Pasteur, Unité Macrophages et Développement de l Immunité and CNRS URA2578, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
Nature 464:112-5. 2010..Here we show by non-invasive, high-resolution imaging of live zebrafish embryos, that HSCs emerge directly from the aortic floor, through a stereotyped process that does not involve ..
- Filtering of visual information in the tectum by an identified neural circuitFilippo Del Bene
Department of Physiology, University of California, San Francisco, CA 94158, USA
Science 330:669-73. 2010The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects...
- In vivo drug discovery in the zebrafishLeonard I Zon
Howard Hughes Medical Institute, Division of Hematology Oncology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Drug Discov 4:35-44. 2005The zebrafish has become a widely used model organism because of its fecundity, its morphological and physiological similarity to mammals, the existence of many genomic tools and the ease with which large, phenotype-based screens can be ..
- Whole-brain functional imaging at cellular resolution using light-sheet microscopyMisha B Ahrens
Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
Nat Methods 10:413-20. 2013..through the genetically encoded calcium indicator GCaMP5G, from the entire volume of the brain of the larval zebrafish in vivo at 0.8 Hz, capturing more than 80% of all neurons at single-cell resolution...
- FGF signalling during embryo development regulates cilia length in diverse epitheliaJudith M Neugebauer
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
Nature 458:651-4. 2009..that fibroblast growth factor (FGF) signalling regulates cilia length and function in diverse epithelia during zebrafish and Xenopus development...
- A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathiesHemant Khanna
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
Nat Genet 41:739-45. 2009..Our data represent an example of modification of a discrete phenotype of syndromic disease and highlight the importance of a multifaceted approach for the discovery of modifier alleles of intermediate frequency and effect...
- nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fateJ A Lister
Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
Development 126:3757-67. 1999We report the isolation and identification of a new mutation affecting pigment cell fate in the zebrafish neural crest. Homozygous nacre (nac(w2)) mutants lack melanophores throughout development but have increased numbers of iridophores...
- Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without ciliaPeng Huang
Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 136:3089-98. 2009..To determine whether the role of cilia is conserved in zebrafish, we generated maternal-zygotic (MZ) oval (ovl; ift88) mutants that lack all cilia...
- RNA-binding protein Dnd1 inhibits microRNA access to target mRNAMartijn Kedde
The Netherlands Cancer Institute, Division of Tumor Biology, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands
Cell 131:1273-86. 2007..protein (RBP), counteracts the function of several miRNAs in human cells and in primordial germ cells of zebrafish by binding mRNAs and prohibiting miRNAs from associating with their target sites...
- Acute inflammation initiates the regenerative response in the adult zebrafish brainNikos Kyritsis
Deutsche Forshungsgemeinschaft Center for Regenerative Therapies Dresden Cluster of Excellence, Technische Universitat Dresden, Fetscherstraße 105, 01307 Dresden, Germany
Science 338:1353-6. 2012The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals...
- A systematic genome-wide analysis of zebrafish protein-coding gene functionRoss N W Kettleborough
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Nature 496:494-7. 2013..Similarly, in zebrafish genetics, one-by-one gene studies using positional cloning, insertional mutagenesis, antisense morpholino ..
- Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiotaJohn F Rawls
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63108, USA
Proc Natl Acad Sci U S A 101:4596-601. 2004..The zebrafish (Danio rerio) provides an opportunity to investigate the molecular mechanisms underlying these interactions through genetic ..
- Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tractMichelle Kanther
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, USA
Gastroenterology 141:197-207. 2011..We used in vivo imaging and molecular approaches to analyze NF-κB activation in response to the commensal microbiota in transparent gnotobiotic zebrafish.
- Bone regenerates via dedifferentiation of osteoblasts in the zebrafish finFranziska Knopf
Biotechnology Center and Center for Regenerative Therapies, University of Technology Dresden, Tatzberg 47 49, 01307 Dresden, Germany
Dev Cell 20:713-24. 2011While mammals have a limited capacity to repair bone defects, zebrafish can completely regenerate amputated bony structures of their fins...
- Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7Fan Sun
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Wuhan 430072, China
J Immunol 187:2531-9. 2011..Further characterization of distinct IFN gene activation reveals that zebrafish IFN1 and IFN3 are induced by the MITA pathway but are dependent on distinct transcription factors...
- Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitorsVolker Kroehne
Biotechnology Center and DFG Research Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Tatzberg 47 49, 01307 Dresden, Germany
Development 138:4831-41. 2011..By contrast, several non-mammalian vertebrate species, including adult zebrafish, have a remarkable ability to regenerate injured organs, including the CNS...
- Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeletonCourtney Alexander
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
Development 138:5135-46. 2011..Here, we use transgenic zebrafish to monitor and perturb BMP signaling during arch formation...
- Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein familyNadia Danilova
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, UCLA, USA
Blood 112:5228-37. 2008..Ribosomal stress syndromes represent a broader spectrum of human congenital diseases caused by genotoxic stress; therefore, imbalance of p53 family members may become a new target for therapeutics...
- Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infectionsDavid M Tobin
Department of Microbiology, University of Washington, Seattle, WA 98195, USA
Cell 148:434-46. 2012..In zebrafish, we find that susceptibility to Mycobacterium marinum can result from either inadequate or excessive acute ..
- BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanomaE Elizabeth Patton
Howard Hughes Medical Institute, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Curr Biol 15:249-54. 2005..To directly test the role of activated BRAF in nevus and melanoma development, we have generated transgenic zebrafish expressing the most common BRAF mutant form (V600E) under the control of the melanocyte mitfa promoter...
- Preservation of duplicate genes by complementary, degenerative mutationsA Force
Department of Biology, University of Oregon, Eugene, Oregon 97403, USA
Genetics 151:1531-45. 1999..We present several examples (including analysis of a new engrailed gene in zebrafish) that appear to be consistent with the DDC model, and we suggest several analytical and experimental approaches ..
- MicroRNA-directed cleavage of HOXB8 mRNASoraya Yekta
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 304:594-6. 2004....
- Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafishSa Kan Yoo
Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, WI 53706, USA
Dev Cell 18:226-36. 2010..The dynamics of PI(3)K products PI(3,4,5)P(3)-PI(3,4)P(2) during neutrophil migration were visualized in living zebrafish, revealing that PI(3)K activation at the leading edge is critical for neutrophil motility in intact tissues...
- Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movementsMichael T Veeman
Department of Pharmacology, Center for Developmental Biology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
Curr Biol 13:680-5. 2003..To further test this hypothesis, we have identified two zebrafish homologs of the Drosophila PCP gene prickle (pk) , both of which show discrete and dynamic expression ..
- The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humansDavid M Tobin
Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195, USA
Cell 140:717-30. 2010..Here we report results from a forward genetic screen in zebrafish larvae that identify multiple mutant classes with distinct patterns of innate susceptibility to Mycobacterium ..
- Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiotaJennifer M Bates
Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
Cell Host Microbe 2:371-82. 2007..Here, we show that expression of the zebrafish intestinal alkaline phosphatase (Iap), localized to the intestinal lumen brush border, is induced during ..
- Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafishJon M Davison
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Dev Biol 304:811-24. 2007Prior studies with transgenic zebrafish confirmed the functionality of the transcription factor Gal4 to drive expression of other genes under the regulation of upstream activator sequences (UAS)...
- SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humansRebecca L Lamason
Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Science 310:1782-6. 2005..Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (..
- Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleasesAnkit Gupta
Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Nucleic Acids Res 39:381-92. 2011..influencing the functional specificity of ZFNs, we compared the in vivo activity of ZFN variants targeting the zebrafish kdrl locus, which display both high on-target activity and dose-dependent toxicity...
- Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafishJennifer Rhodes
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Dev Cell 8:97-108. 2005The zebrafish is a powerful model system for investigating embryonic vertebrate hematopoiesis, allowing for the critical in vivo analysis of cell lineage determination...
- Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafishJonathan R Mathias
University of Wisconsin Madison, 2715 Medical Sciences Center, 1300 University Ave, Madison, WI 53706, USA
J Leukoc Biol 80:1281-8. 2006..the mechanisms that regulate neutrophil-mediated inflammation in vivo, we have developed a novel transgenic zebrafish in which the neutrophils express GFP under control of the myeloperoxidase promoter (zMPO:GFP)...
- Hematopoietic stem cell development is dependent on blood flowTrista E North
Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 137:736-48. 2009..We report here that blood flow is a conserved regulator of HSC formation. In zebrafish, chemical blood flow modulators regulated HSC development, and silent heart (sih) embryos, lacking a heartbeat ..
- Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesisYong Zhao
Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
Nature 436:214-20. 2005..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis...
- Structures of SAS-6 suggest its organization in centriolesMark van Breugel
Medical Research Council Laboratory of Molecular Biology MRC LMB, Hills Road, Cambridge, UK
Science 331:1196-9. 2011..We determined the x-ray structure of the amino-terminal domain of SAS-6 from zebrafish, and we show that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers...
- Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulationC P Heisenberg
Department of Anatomy and Developmental Biology, University College, London, UK
Nature 405:76-81. 2000..Here we show that the zebrafish silberblick (slb) locus encodes Wnt11 and that Slb/Wnt11 activity is required for cells to undergo correct ..
- Regulation of embryonic cell adhesion by the prion proteinEdward Malaga-Trillo
Department of Biology, University of Konstanz, Konstanz, Germany
PLoS Biol 7:e55. 2009..We report a strong PrP loss-of-function phenotype in zebrafish embryos, characterized by the loss of embryonic cell adhesion and arrested gastrulation...
- Notch signalling limits angiogenic cell behaviour in developing zebrafish arteriesArndt F Siekmann
Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nature 445:781-4. 2007..is necessary to restrict angiogenic cell behaviour to tip cells in developing segmental arteries in the zebrafish embryo...
- Distinct Wnt signaling pathways have opposing roles in appendage regenerationCristi L Stoick-Cooper
Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
Development 134:479-89. 2007..Using transgenic fish lines, we show that Wnt/beta-catenin signaling is activated in the regenerating zebrafish tail fin and is required for formation and subsequent proliferation of the progenitor cells of the blastema...
- The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fishChris Hall
Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
BMC Dev Biol 7:42. 2007..Recently, the zebrafish has been exploited to model aspects of human disease and to study specific immune cell compartments using ..
- Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasisTrista E North
Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 447:1007-11. 2007..and homeostasis, a panel of biologically active compounds was screened for effects on stem cell induction in the zebrafish aorta-gonad-mesonephros region...
- Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypesMika Asai-Coakwell
Department of Ophthalmology, University of Alberta, Edmonton, Canada
Hum Mol Genet 18:1110-21. 2009..We observed a spectrum of ocular and skeletal anomalies in morphant zebrafish, the latter encompassing defective tail formation and altered expression of somite markers noggin1 and noggin2...
- Activated ALK collaborates with MYCN in neuroblastoma pathogenesisShizhen Zhu
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 21:362-73. 2012..We generated a transgenic zebrafish model of neuroblastoma in which MYCN-induced tumors arise from a subpopulation of neuroblasts that migrate into ..
- Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2Jun Dae Kim
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, CT 06511, USA
Dev Cell 23:441-8. 2012..We have recently shown that BMP2 signaling promotes venous-specific angiogenesis in zebrafish embryos...
- Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophagesChao Tsung Yang
Department of Microbiology, University of Washington, Seattle, WA 98195, USA
Cell Host Microbe 12:301-12. 2012..Here we exploit the genetic tractability and optical transparency of zebrafish to monitor neutrophil behavior and its consequences during infection with Mycobacterium marinum, a natural fish ..
- Physical interaction between TBX5 and MEF2C is required for early heart developmentTushar K Ghosh
Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
Mol Cell Biol 29:2205-18. 2009..Morpholino-mediated knockdowns of Tbx5 and Mef2c in zebrafish suggest that the genetic interaction of these proteins is not only required for MYH6 expression but also ..
- A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreceptionNicola Cavallari
Department of Biology and Evolution, University of Ferrara, Ferrara, Italy
PLoS Biol 9:e1001142. 2011..Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness...
- The zebrafish transcriptome during early developmentLiselotte Vesterlund
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
BMC Dev Biol 11:30. 2011..In this study RNA-Seq is used to compare the transcription profiles of four early developmental stages in zebrafish (Danio rerio) on a global scale.
- A genetic screen for mutations affecting embryogenesis in zebrafishW Driever
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:37-46. 1996..Male zebrafish were mutagenized with N-ethyl N-nitrosourea to induce mutations in spermatogonial cells at an average specific ..
- Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializationsHeather Flanagan-Steet
Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
Development 132:4471-81. 2005..Here, we used neuromuscular junctions (NMJs) of the zebrafish primary motor system to test this model...
- Validation of zebrafish (Danio rerio) reference genes for quantitative real-time RT-PCR normalizationRongying Tang
School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
Acta Biochim Biophys Sin (Shanghai) 39:384-90. 2007..qRT-PCR has only recently been used in terms of zebrafish gene expression studies and there is no validated set of reference genes...
- Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulationTakamasa Mizoguchi
Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama 1 3 1, Higashi Hiroshima, Hiroshima, Japan
Development 135:2521-9. 2008..In zebrafish, the internalized mesodermal cells move towards the dorsal side of the gastrula and, at the same time, they ..
- Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heartEmma de Pater
Hubrecht Institute and University Medical Centre Utrecht, 3584 CT, Utrecht, The Netherlands
Development 136:1633-41. 2009..for the evolutionary adaptation of heart size, we studied how growth of the simple two-chambered heart in zebrafish is regulated...
- Chromatin signature of embryonic pluripotency is established during genome activationNadine L Vastenhouw
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nature 464:922-6. 2010..H3 molecules bearing lysine trimethylation modifications before and after the maternal-zygotic transition in zebrafish. Histone H3 lysine 27 trimethylation (H3K27me3), which is repressive, and H3K4me3, which is activating, were not ..
- The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletionJinhu Wang
Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Development 138:3421-30. 2011Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in size...
- Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regenerationWolfram Goessling
Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Cell 136:1136-47. 2009..Here, we show that wnt reporter activity in zebrafish HSCs is responsive to PGE2 modulation, demonstrating a direct interaction in vivo...
- The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryoS Schulte-Merker
Abteilung Genetik, Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
Development 116:1021-32. 1992..We report the cloning and sequencing of the T gene in the zebrafish (Brachydanio rerio) and show the nuclear localization of the protein product...
- Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesisLisa M Baye
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurosci 27:10143-52. 2007..Using time-lapse imaging in zebrafish, we show that various parameters of interkinetic nuclear migration are significantly heterogeneous among retinal ..
- Control of chemokine-guided cell migration by ligand sequestrationBijan Boldajipour
Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
Cell 132:463-73. 2008Primordial germ cell (PGC) migration in zebrafish is directed by the chemokine SDF-1a that activates its receptor CXCR4b. Little is known about the molecular mechanisms controlling the distribution of this chemoattractant in vivo...
- Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cellsNikolaus Obholzer
Howard Hughes Medical Institute, Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurosci 28:2110-8. 2008..Here we report that asteroid, a gene identified in an ethylnitrosourea mutagenesis screen of zebrafish larvae for auditory/vestibular mutants, encodes vesicular glutamate transporter 3 (Vglut3)...
- Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafishJose Bessa
Centro Andaluz de Biologia del Desarrollo, CSIC Universidad Pablo de Olavide, Campus UPO, Seville, Spain
Dev Dyn 238:2409-17. 2009..Here, we describe a novel Tol2 transposon-based vector for assessing enhancer activity in the zebrafish (Danio rerio)...
- Effective targeted gene 'knockdown' in zebrafishA Nasevicius
Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA
Nat Genet 26:216-20. 2000The sequencing of the zebrafish genome should be completed by the end of 2002...
- Phylogenetic timing of the fish-specific genome duplication correlates with the diversification of teleost fishSimone Hoegg
Department of Biology, University of Konstanz, 78457 Konstanz, Germany
J Mol Evol 59:190-203. 2004..The discovery of an additional, almost-complete set of Hox clusters in teleosts (zebrafish, pufferfish, medaka, and cichlid) but not in basal actinopterygian lineages ( Polypterus) led to the formulation ..
- Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivoFrancesca Peri
Max Planck Institute for Developmental Biology, Spemannstr 35, 72076 Tubingen, Germany
Cell 133:916-27. 2008..Here, we exploit a microglial population in the zebrafish to study this process in intact living brains...
- Crowding induces live cell extrusion to maintain homeostatic cell numbers in epitheliaGeorge T Eisenhoffer
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA
Nature 484:546-9. 2012..However, it is not clear what drives cell death during normal homeostasis. Here we show in human, canine and zebrafish cells that overcrowding due to proliferation and migration induces extrusion of live cells to control epithelial ..
- Extensive alternative polyadenylation during zebrafish developmentIgor Ulitsky
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genome Res 22:2054-66. 2012..profiling by sequencing (3P-seq) to map poly(A) sites at eight developmental stages and tissues in the zebrafish. Analysis of over 60 million 3P-seq reads substantially increased and improved existing 3' UTR annotations, ..
- Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryosLan Jiang
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
Cell 153:773-84. 2013..We generated nine single-base resolution DNA methylomes, including zebrafish gametes and early embryos. The oocyte methylome is significantly hypomethylated compared to sperm...
- Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesisAnnie N Y Ng
Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Dev Biol 286:114-35. 2005Recent analysis of a novel strain of transgenic zebrafish (gutGFP) has provided a detailed description of the early morphological events that occur during the development of the liver and pancreas...
- Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA virusesStephane Biacchesi
INRA, CRJ, Jouy en Josas, France
J Virol 83:7815-27. 2009..In this study, we cloned MAVS cDNAs from several fish species (including salmon and zebrafish) and showed that they were orthologs of mammalian MAVS...
- Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalonMartin März
Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe in the Helmholtz Association, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
Glia 58:870-88. 2010The zebrafish has become a new model for adult neurogenesis, owing to its abundant neurogenic areas in most brain subdivisions...
- Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gutJeffrey J Essner
Huntsman Cancer Institute, Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
Development 132:1247-60. 2005..In zebrafish, dorsal forerunner cells (DFCs) express a conserved ciliary dynein gene (left-right dynein-related1, lrdr1) and ..
- Her6 regulates the neurogenetic gradient and neuronal identity in the thalamusSteffen Scholpp
MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, United Kingdom
Proc Natl Acad Sci U S A 106:19895-900. 2009..Here we describe the existence of a neurogenetic gradient in the zebrafish thalamus and show that the progression of neurogenesis is controlled by dynamic expression of the bHLH repressor ..
- Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromesEnza Maria Valente
Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Nat Genet 42:619-25. 2010..Disruption of tmem216 expression in zebrafish caused gastrulation defects similar to those in other ciliary morphants...
- Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retinaJeffrey M Gross
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 102:4371-6. 2005..the development of this retinal axis, we have characterized a T-box family transcription factor, Tbx2b, during zebrafish retinogenesis...
- Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafishJun Chen
Laboratory of Functional Genomics, Laboratory of Molecular and Developmental Immunology, Laboratory of Control of p53 Pathway, Institute of Molecular and Cell Biology, Proteos, Singapore 138673
Genes Dev 19:2900-11. 2005..Here we present evidence to show that the zebrafish def (digestive-organ expansion factor) gene encodes a novel pan-endoderm-specific factor...
- Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAsAntonio J Giraldez
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Science 312:75-9. 2006..b>Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development...
- N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafishElim Hong
Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
Development 133:3895-905. 2006..analysis of cell behaviors, we address the mechanisms underlying anterior neural tube morphogenesis in the zebrafish and the role of the cell adhesion molecule N-cadherin (N-cad) in this process...
- Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cellsRebecca L Bernardos
Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
J Neurosci 27:7028-40. 2007..To examine the neurogenic capacity of retinal glial cells, we used lineage tracing in transgenic zebrafish with a glial-specific promoter (gfap, for glial fibrillary acid protein) driving green fluorescent protein in ..
- C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesisJie Mei
State Key Laboratory of Freshwater Ecology and Biotechnology, Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, China
Dev Biol 319:273-84. 2008..Here we describe zebrafish C1q-like, whose transcription and translation display a uniform distribution in early embryos, and are ..
- miR-129-3p controls cilia assembly by regulating CP110 and actin dynamicsJingli Cao
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Nat Cell Biol 14:697-706. 2012..Moreover, miR-129-3p inhibition in zebrafish embryos suppressed ciliation in Kupffer's vesicle and the pronephros, and induced developmental abnormalities ..
Research Grants128 found, 100 shown here
- Characterization of diverse melanopsin-expressing cells in zebrafishVANESSA MATOSCRUZ; Fiscal Year: 2011..I have identified five opn4-related genes in the zebrafish that show unique and non-overlapping patterns in the retina...
- Trans-Cellular Activation of Transcription to Analyze Dopaminergic Axon ReorganizJOSH LEITCH BONKOWSKY; Fiscal Year: 2012..elegans to prevent cross-reactivity with the endogenous zebrafish proteins...
- Jenean O'Brien; Fiscal Year: 2015..In zebrafish there are two SIX1 homologs, six1a and six1b, with little known about the role of six1a...
- Dissection of SREBP/ATF6 crosstalk in alcohol-induced steatosisDeanna L Howarth; Fiscal Year: 2013..data that suggests depletion of a key mediator of the UPR, ATF6, reduces alcoholic steatosis in larval zebrafish, a novel tool for studying ALD...
- KRISTIN EMILY NOACK WATT; Fiscal Year: 2015..blot analysis that p53-dependent apoptosis contributes to craniofacial anomalies in polr1c and polr1d mutant zebrafish. We hypothesize that genetic inhibition of p53 in polr1c and polr1d zebrafish will prevent the pathogenesis of ..
- Holly Richendrfer; Fiscal Year: 2014..the impact of small doses of Chlorpyrifos and Malathion on brain development and anxiety-related behavior using zebrafish embryos...
- SULT4A1 Function in Zebrafish DevelopmentCharles N Falany; Fiscal Year: 2013..is to establish the regulation and function of sulfotransferase (SULT) 4A1 in the developing zebrafish (Danio rerio) embryo/larval model system...
- SARAH KELLY MCMENAMIN; Fiscal Year: 2014..This research utilizes the zebrafish, which undergoes extensive post-embryonic development involving modifications and maturation in many different ..
- CHRISTIE ANNE CIARLO; Fiscal Year: 2015..A previous screen of 2000 compounds for suppressors of the neural crest lineage in zebrafish embryos pointed to inhibitors of dihydroorotate dehydrogenase (DHODH)...
- CHRISTOPHER VYVIAN ERIC WRIGHT; Fiscal Year: 2016..model systems, relying on the 20-year foundation built in expertise in yeast, nematode worms, fruit flies, zebrafish, chicken, and mouse...
- Grigorios Oikonomou; Fiscal Year: 2015..b>Danio rerio (zebrafish) larvae are optically transparent and have only ~10 Hcrt and ~6 LC neurons per hemisphere...
- Genes required for lipid processing and digestive organ function in larval zebrafSteven A Farber; Fiscal Year: 2011..metabolism that can track FAs from their site of absorption at the intestinal brush border of 6-day old zebrafish larvae, through the circulatory system, and ultimately to lipid drops within a variety of organs...
- JESSICA OTIS; Fiscal Year: 2014..As a first step in exploring CAV1, drCav1-GFP zebrafish were created that show in vivo drCav1 localization to the basolateral and lateral plasma membranes of ..
- GARY WILLIAM LITMAN; Fiscal Year: 2014..VCBPs will be examined through direct study of meiotic variants as well as by plasmid- and BAC-transgenesis in zebrafish as a high throughput readout system...
- The role of GABAB signaling during axon guidance in the developing zebrafishALEMJI TAKU; Fiscal Year: 2011..The role of GABAB receptors in axon guidance will be explored in vivo using the zebrafish retinal projection as a model and in vitro using primary neuronal cultures derived from embryonic chick retinal ..
- The Role of Phosphorylation in Photoreceptor Cell BiologyELLEN RUTH WEISS; Fiscal Year: 2010..mice are not an appropriate model for studying the role of these 2 kinases in human vision, we propose to use zebrafish larvae as a model to define the functional consequences of GRK1 and GRK7 phosphorylation by PKA...
- Structure-function analysis of zebrafish encoded 3-OST enzyme for HSV-1 EntryVaibhav Tiwari; Fiscal Year: 2011..My current research demonstrates that expression of zebrafish (ZF) encoded 3-OST-3 allow HSV-1 entry in resistant CHO-K1 cells, while pre-treatment of ZF embryos with ..
- Molecular Genetics of Otolith Formation in the ZebrafishRichard Kollmar; Fiscal Year: 2009..of this proposal are, therefore, first to determine the sequence of the about two dozen constituent proteins of zebrafish otoliths;second, to examine the proteins'expression patterns;and third, to test whether these proteins are ..
- Niles A Pierce; Fiscal Year: 2014..performance was achieved when imaging five target mRNAs simultaneously in fixed whole-mount and cross-sectioned zebrafish embryos...
- Function and Regulation of PKA-mediated GRK Phosphorylation in PhotoreceptorsJARED DAVID CHRISPELL; Fiscal Year: 2013..an appropriate model for studying the role of these two kinases in regards to human vision, we propose to use zebrafish larvae as a model to define the functional consequences of Grk1 and Grk7 phosphorylation by PKA...
- Charles B Kimmel; Fiscal Year: 2014..It utilizes zebrafish as a model system...
- wnt Signaling in Liver Development and DiseaseWolfram Goessling; Fiscal Year: 2009..The zebrafish is an excellent model to study early vertebrate development because of its translucency during development and ..
- Rebecca G Wells; Fiscal Year: 2014..glomulifera from the Australian pasture affected by the most recent epidemic and have employed a zebrafish bioassay to successively subfractionate the plant and identify active fractions...
- Steven A Farber; Fiscal Year: 2016..methods to image lipid uptake, transport and storage, within complex organs composed of many cell types in live zebrafish. The Farber lab has established tools to visualize the cellular dynamics of dietary FA in zebrafish larvae, ..
- MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL REGULATIONMichael R Green; Fiscal Year: 2013..During the past funding period we have found that Trf3-depleted zebrafish embryos exhibit multiple developmental defects and, in particular, fail to undergo hematopoiesis...
- Mary C Mullins; Fiscal Year: 2015..The zebrafish has provided a valuable vertebrate model for human development and disease...
- Iain A Drummond; Fiscal Year: 2014..We have modeled polycystic kidney disease in the zebrafish by disrupting the function of polycystin1 and polycystin2...
- ONTOGENY AND PHYLOGENY OF THE MHCMartin Flajnik; Fiscal Year: 2009..g. zebrafish)...
- Scott T Laughlin; Fiscal Year: 2015..to study the neural circuiry underlying olfaction in a system that is at least 10 times simpler than mice, the zebrafish larvae...
- BMP signaling in vertebrate developmentKen W Y Cho; Fiscal Year: 2013..a core BMP-responsive element (BRE) that responds specifically to BMP signaling from Drosophila to Xenopus, zebrafish and mouse. 2...
- Yury Miller; Fiscal Year: 2014..In this application, we propose to develop new zebrafish (Danio rerio) models to study mechanisms and pathologic effects of lipoprotein oxidation, new imaging techniques targeting ..
- The role of carboxypeptidase A6 in developmentPETER JONATHAN LYONS; Fiscal Year: 2010..The distribution of CPA6 will be characterized in detail throughout the development of the zebrafish using in situ hybridization, while the distribution of CPA6 in the mouse will be pursued by a collaborator...
- Establishing zebrafish as a model for rai1 gene dosageJames A Lister; Fiscal Year: 2010..The studies proposed seek to develop zebrafish as model for studying gene dosage requirements for rai1...
- Signaling pathways and expansion of hematopoietic stem cells in zebrafishJILL L DE JONG; Fiscal Year: 2010..The zebrafish mutant kugelig (kgg) has a severe defect in hematopoiesis, as well as altered anterior-posterior patterning and ..
- Oral Clefts: Moving from Genome Wide Studies Toward Functional GenomicsTerri H Beaty; Fiscal Year: 2013..1) and to conduct functional genomic studies of these same genes to understand how they act in vivo using the zebrafish model (Aim 2)...
- Gene Discovery in Human Anopthalmia/MicropthalmiaAnne M Slavotinek; Fiscal Year: 2013..We will use our previous methodology of in-situ hybridization in mouse and morpholino or mRNA injections in Danio rerio to examine the effects of loss or gain of candidate gene function on eye development, respectively, to ..
- Wnt targets in hypothalamic neurogenesisRichard I Dorsky; Fiscal Year: 2010..We have identified a specific role for Wnt signaling, acting through Lef1, in the development of zebrafish GABAergic hypothalamic neurons...
- KIRSTEN C SADLER EDEPLI; Fiscal Year: 2016..Moreover, in vivo models are needed to test candidate drugs. We use zebrafish larvae to study the genes and pathways that lead to steatosis...
- Alex Nechiporuk; Fiscal Year: 2016..basis of the cellular and molecular mechanisms, which regulate axon transport and microtubule dynamics using the zebrafish as an in vivo model system...
- Genetic Analysis of Acoustic Startle Behavior and CircuitsKurt C Marsden; Fiscal Year: 2013..Here I propose to use the powerful zebrafish model system to investigate the mechanisms of startle regulation...
- Lalita Ramakrishnan; Fiscal Year: 2014..Adult zebrafish develop caseating granulomatous tuberculosis similar to active human tuberculosis...
- EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENESGARY LITMAN; Fiscal Year: 2009..VCBPs will be examined through direct study of meiotic variants as well as by plasmid- and BAC-transgenesis in zebrafish as a high throughput readout system...
- EDWARD ALAN BURTON; Fiscal Year: 2014..in developing drugs to target Tau accumulation and its consequences in neurons in vivo, we propose to develop zebrafish Tauopathy models that are optimized for drug discovery efforts, rapid comparative testing of putative ..
- Roles of the microbiota and Notch signaling in specifying cell fateJoshua V Troll; Fiscal Year: 2011..My sponsor's lab has demonstrated that the microbiota of the zebrafish, Danio rerio, influences cell-fate specification in the intestinal epithelium...
- Hang Lu; Fiscal Year: 2016..applicable to areas such as developmental cell biology, and to other small organisms such as fly larvae and zebrafish embryos...
- Ontogeny of the Phase II cytosolic sulfotransferases and adverse drug reactionsMing Cheh Liu; Fiscal Year: 2013..In our recent studies using the zebrafish as a model, we demonstrated that different SULTs exhibited distinct patterns of expression at different stages ..
- Genetic and Genomic Approaches to Study Hair Cell Regeneration in ZebrafishMartine Behra; Fiscal Year: 2013..As an entry point, we are using a zebrafish mutant line (phoenix), which we have characterized...
- Scott A Holley; Fiscal Year: 2014..Within the zebrafish segmentation clock, six members of the her/hes family form both hetero- and homodimers and negatively regulate ..
- Michael Granato; Fiscal Year: 2014..In humans, habituation deficits are a central feature of cognitive disorders, including schizophrenia. Zebrafish larvae display a remarkable repertoire of behaviors and we find that larvae exhibit non-associative learning (..
- DANIEL ALLEN LEE; Fiscal Year: 2015..I will exploit the relatively simple yet conserved neural circuits of the zebrafish, a diurnal vertebrate, to test several hypotheses regarding the role of transforming growth factor alpha (TGF-..
- KIMBERLY MCARTHUR; Fiscal Year: 2015..By applying a unique combination of state-of-the-art techniques and available resources in the larval zebrafish model, I hope to shed light on the complex roles of migration in circuit formation, by studying the effect of ..
- Determining the molecular mechanism by which prdm1a regulates neural crest specifDAVALYN RENEE POWELL; Fiscal Year: 2013DESCRIPTION (provided by applicant): The zebrafish mutant, narrowminded (nrd), is a mutation in the gene encoding the Prdm1a (or Blimp1) transcription factor which results in a reduction in neural crest cells and downregulation of ..
- Zebrafish Based Model for Gastrointenstinal PhysiologyADAM J RICH; Fiscal Year: 2010..The specific objective of this AREA proposal is to establish the zebrafish as a model system to study the role of ICC in GI motility...
- Richard I Dorsky; Fiscal Year: 2014..The zebrafish larva is an excellent system to study circuits: it has well-established behaviors, can be manipulated ..
- Identifying colon cancer modifier genes with zebrafishMichael A Pack; Fiscal Year: 2010..a strategy to identify genes that regulate cancer cell invasion, an early step in cancer metastasis, using the zebrafish. We have shown that zebrafish meltdown (mlt) mutants develop a cancer-like phenotype as a result of stromal ..
- Building a Gene Regulatory Network for prdm1a During Zebrafish Craniofacial DevelKRISTI A LAMONICA; Fiscal Year: 2013..morpholinos, will be used to perturb gene function to determine if target knockdown phenocopies prdm1a mutant zebrafish. Rescue experiments will be performed using mRNA injection into prdm1a mutant zebrafish to determine if target ..
- The Vertebrate Translocon Sec61alpha is Required for Habenular AsymmetryCALEB ANDREW DOLL; Fiscal Year: 2012..We have implicated a secretory pathway gene as a contributing factor to developing asymmetry in the zebrafish. This gene, sec61alpha1, is the major subunit of the vertebrate translocon, a pore on the endoplasmic reticulum ..
- Z Jimmy Zhou; Fiscal Year: 2016..and theoretical neuroscience, as well as from the range of experimental models used in these studies, spanning zebrafish, rodents, and primates...
- High-Throughput Screen For FDA Approved Drugs That Amplify Beta-Cell Mass In VivoMICHAEL contact PARSONS; Fiscal Year: 2010..in the molecular mechanisms that control vertebrate pancreas development;therefore, we have turned to the zebrafish as an alternative model system to study [unreadable]-cell biology...
- Kara E Powder; Fiscal Year: 2015..this proposal is evaluate the role of a largely uncharacterized gene, limb bud and heart homolog (lbh), during zebrafish craniofacial development...
- Genetic Analyst of Early Conduction System DevelopmentRima Arnaout; Fiscal Year: 2012..First, we will establish molecular markers of the specialized ventricular cardiac conduction system in zebrafish. We will test the hypotheses that the location of the first cells of the conduction system are located in the ..
- ANATOMICAL AND BIOCHEMICAL ORGANIZATION OF THE RETINAJohn E Dowling; Fiscal Year: 2010The zebrafish is an ideal model system in which to study the effects of genetic mutations on eye development and function...
- ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2016..elegans, Drosophila, planarians, ascidians, sea urchins, zebrafish, amphibians, chick and mouse...
- Center for in Toto Genomic Analysis of Vertebrate DevelopmentScott E Fraser; Fiscal Year: 2011..Initially, key technologies will be developed and tested in the zebrafish embryo due to its transparency and the ability to obtain rapid feedback...
- Large scale generation of anti-zebrafish monoclonal antibodiesGAVIN JAMES WRIGHT; Fiscal Year: 2012This proposal outlines how a unique resource of zebrafish cell surface and secreted proteins will be used in conjunction with a novel method of antibody selection to create a resource of 200 new zebrafish monoclonal antibody reagents...
- Embryonic Expression and Roles of Neuronal Connexin 35 in Zebrafish Spinal CordTara Martin; Fiscal Year: 2013..This study takes advantage of the Danio rerio (zebrafish) model to determine whether the neuronal specific connexin 35 (Cx35) plays a fundamental role in the ..
- Genetics 2012: Model Organism to Human CancerPAUL WARREN STERNBERG; Fiscal Year: 2012..g., yeast, worms, flies, zebrafish, mouse)...
- Targeted Manipulation of the Zebrafish Genome through Homologous RecombinationBrian Ciruna; Fiscal Year: 2010DESCRIPTION (provided by applicant): In many respects, the zebrafish surpasses the mouse in utility as a model organism for understanding human embryonic development and disease...
- WILSON KENDRICK CLEMENTS; Fiscal Year: 2014..Using zebrafish, which are transparent during embryonic development and uniquely receptive to transgenesis, allowing direct ..
- FLORENCE LOUISE MARLOW; Fiscal Year: 2016..Studies of the genetic and molecular control of axis formation in zebrafish will clarify the mechanisms establishing these earliest oocyte asymmetries, which are conserved...
- Michel Bagnat; Fiscal Year: 2016..Recent work in zebrafish from our laboratory has shown that notochord vacuoles are specialized lysosome-related organelles...
- Jenna L Galloway; Fiscal Year: 2015..To accomplish this, we will use the zebrafish, a powerful genetic and developmental vertebrate model system'...
- Scot A Wolfe; Fiscal Year: 2016DESCRIPTION (provided by applicant): The zebrafish has characteristics that make it an ideal model organism for studying genetic determinants that participate in development and disease...
- Jonathan A Raper; Fiscal Year: 2016..takes advantage of the relative simplicity, rapid development, and experimental accessibility of the embryonic zebrafish to study the guidance of sensory neurons...
- David M Parichy; Fiscal Year: 2014..This work exploits the post-embryonic development of zebrafish melanophores, homologues of mammalian melanocytes, as an especially tractable system for studying stem and ..
- Iswar K Hariharan; Fiscal Year: 2016..Remarkably, these same tissues can regenerate in animals such as the zebrafish and the newt...
- David M Parichy; Fiscal Year: 2016..tractable example of boundary formation, the development and maintenance of adult pigment stripes in the zebrafish. Previous efforts demonstrated that interactions between different classes of pigment cells are essential for ..
- LILIANNA SOLNICAKREZEL; Fiscal Year: 2015..Motivated by these findings, we identified and analyzed the expression of 32 zebrafish genes encoding chemokine GPCRs and discovered that more than half of them are expressed, and several have ..
- Michael J Parsons; Fiscal Year: 2016..in the molecular mechanisms that control vertebrate pancreas development and function, we have turned to the zebrafish as an alternative model system to study beta-cell biology and regeneration...
- Lauren Brilli Skvarca; Fiscal Year: 2016..m4PTB), enhances tubular cell proliferation and renal regeneration when administered post-injury in both zebrafish and mouse AKI models...
- Lalita Ramakrishnan; Fiscal Year: 2014..My laboratory has developed zebrafish infection by Mycobacterium marinum as a powerful surrogate model for exploring tuberculosis pathogenesis...
- Alberto E Pereda; Fiscal Year: 2014..will take this unique model mixed synapse to a new level of analysis by investigating their properties in larval zebrafish, whose transparency will make it possible to track individual molecules within living cells, in vivo...
- TERESA A NICOLSON; Fiscal Year: 2016..greatly aided in our understanding of biological processes and disease, and we aim to expand the ability of the zebrafish community to screen for components critical to development and function...
- Novel System for Automation of Zebrafish Lipid AssaysANTHONY FERRANTE; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): The zebrafish, Danio rerio, has become widely accepted as a useful model for vertebrate development...
- Genetic Analysis of Primary Immunodeficiency using Transgenic ZebrafishNikolaus Trede; Fiscal Year: 2009The zebrafish represents a powerful model for the study of vertebrate diseases, particularly those of the hematopoietic and immune systems...
- Whole organism transcriptional profiling of innate immune responseJeffrey Yoder; Fiscal Year: 2009..The zebrafish larva provides a unique model for overcoming this obstacle as the larva successfully defends itself from ..
- Novel System to Automate Zebrafish Angiogenesis AssaysANTHONY FERRANTE; Fiscal Year: 2005The zebrafish, Danio rerio, has become widely accepted as a model for human disease. There is strong interest in developing zebrafish as a model organism for use in high throughput drug discovery assays...
- Priyabrata Mukherjee; Fiscal Year: 2016..Furthermore, silencing of CBS by siRNA leads to increased ROS production in HUVECs;c) Knockdown of CBS in zebra fish exhibits defects in notochord development and vascular defects...
- Ellen Merrick Schill; Fiscal Year: 2015..a non-steroidal anti-inflammatory drug (NSAID) commonly used in pregnancy, inhibited ENCC migration in a zebrafish drug screen, causing a HSCR-like distal bowel aganglionosis in affected fish...
- DHVANIT INDRAVADAN SHAH; Fiscal Year: 2014..The zebrafish, with its close synteny to the human genome and its conserved molecular pathways regulating the development of ..
- The Molecular Genetics of Early NeurogenesisEthan Bier; Fiscal Year: 2013..and analyze vertebrate CRMs driving differential expression of neural identity genes in the neural plate/tube of zebrafish embryos. In collaboration with Shannon Fisher's group (Univ...
- Development and Functional Analysis of Components of the Zebrafish Serotonin SignKenneth N Wallace; Fiscal Year: 2012..We will investigate the role of the serotonin signaling system to determine how it functions within the zebrafish digestive system...
- Weibin Zhou; Fiscal Year: 2015..To address these questions, I propose to establish zebrafish mesonephros as a new model system for nephrotic syndrome by: (1) utilizing the transgenic zebrafish models that ..
- Adam C Miller; Fiscal Year: 2014..This proposal utilizes the zebrafish Mauthner (M) circuit to investigate the genetics of electrical synapse formation...
- Todd R Miller; Fiscal Year: 2016..In addition, a zebrafish assay will be used to detect unknown toxins and overall water toxicity...
- Joseph G Gleeson; Fiscal Year: 2015..We will utilize both traditional and conditional knockout technologies in mouse, genetic modeling in zebrafish, and advanced live-cell imaging capability that will synergize to help advance our understanding of the ..
- Dale Warren Hailey; Fiscal Year: 2014..I will use zebrafish lateral line hair cells because we can easily image these cells in their native context while exposing them to ..
- The role of the kimble gene in regulating craniofacial morphogenesisDaniel S Levic; Fiscal Year: 2013..By investigating a zebrafish mutant with a malformed head skeleton, this project has identified impaired exocytosis as a potentially novel ..
- Stuart H Orkin; Fiscal Year: 2015..was based on the premise that parallel genetic investigation of the major vertebrate model organisms, mice and zebrafish, would advance our understanding of fundamental aspects of blood cell formation, provide a platform for new ..
Patents219 found, 100 shown here
- METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124Patent Number: JP2016507218-A; Date:2016-03-10
- Nucleic acids sequence of a cell death-inducible vector, and the transgenic silkmoth strains carrying the DNA fragment inducing tissue-specific cell deathPatent Number: JP2016144416-A; Date:2016-08-12
- AGENT FOR PROMOTING RETINA REGENERATIONPatent Number: WO2016125330-A; Date:2016-08-11
- Nucleic acids sequence of a cell death-inducible vector, and the transgenic silkmoth strains carrying the DNA fragment inducing tissue-specific cell deathPatent Number: WO2016125885-A; Date:2016-08-11
- Dyrk1aa mutant zebrafish model for vascular disease and screening method of vascular disease treatment agent using the samePatent Number: KR1020160012735-A; Date:2016-02-03
- PROTEIN COMPRISING A COLLAGEN DOMAIN OF CCBE1 AND USES THEREOFPatent Number: WO2016043591-A1; Date:2016-03-24
- METHOD OF PRODUCING INFERTILE FISH AND EGG-PRODUCING AQUATIC ANIMALS AND OF DELIVERING COMPOUNDS INTO EGGS AND EMBRYOSPatent Number: EP3068216-A1; Date:2016-09-21
- POLYPEPTIDES, NUCLEIC ACIDS AND USES THEREOFPatent Number: EP3077413-A1; Date:2016-10-12
- Differentiation marker and differentiation control of ocular cellsPatent Number: WO2014007402-A; Date:2014-01-09
- Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferasesPatent Number: JP2014036669-A; Date:2014-02-27
- IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAINPatent Number: JP2014001243-A; Date:2014-01-09
- AGENT FOR INDUCING CARDIOMYOCYTE PROLIFERATION, PHRMACEUTICAL COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING CARDIOMYOCYTEPatent Number: WO2015045333-A; Date:2015-04-02
- PROCESSES FOR PRODUCING LIPIDSPatent Number: JP2015511118-A; Date:2015-04-16
- New application of acetylated enzyme competitive inhibitor Gm16515Patent Number: JP2015134723-A; Date:2015-07-27
- Archease as rna ligase complex memberPatent Number: JP2015515485-A; Date:2015-05-28
- DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIESPatent Number: JP2014131515-A; Date:2014-07-17
- Method of identifying eukaryotic speciesPatent Number: JP2014155500-A; Date:2014-08-28
- YEAST STRAIN FOR THE PRODUCTION OF PROTEINS WITH MODIFIED O-GLYCOSYLATIONPatent Number: EP2678440-A2; Date:2014-01-01
- C1Q/TNF-RELATED PROTEIN 12 AND COMPOSITIONS AND METHODS OF USING SAMEPatent Number: EP2696886-A2; Date:2014-02-19
- PROCESSES FOR PRODUCING LIPIDSPatent Number: EP2798066-A1; Date:2014-11-05
- NEUROCALCIN DELTA INHIBITORS AND THERAPEUTIC AND NON-THERAPEUTIC USES THEREOFPatent Number: WO2015014838-A1; Date:2015-02-05
- Interaction of Draxin and y-NetrinsPatent Number: EP2899205-A1; Date:2015-07-29
- METHOD, PROBE AND KIT FOR DNA IN SITU HYBRIDATION AND USE THEREOFPatent Number: JP2014509862-A; Date:2014-04-24
- Polypeptide VaccinePatent Number: JP2014526462-A; Date:2014-10-06
- TIKI INHIBITORSPatent Number: EP2836514-A1; Date:2015-02-18
- MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS BY EXPRESSION OF NON-MAMMALIAN GLYCOSYLTRANSFERASESPatent Number: KR1020140059871-A; Date:2014-05-16
- YEAST STRAIN FOR THE PRODUCTION OF PROTEINS WITH MODIFIED O-GLYCOSYLATIONPatent Number: KR1020140114278-A; Date:2014-09-26
- Process for the production of fine chemicalsPatent Number: EP2194140-A2; Date:2010-06-09
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