zebrafish

Summary

Alias: zebra danio, zebra fish, Danio rerio, Brachydanio rerio, Brachidanio rerio, leopard danio, Brachydanio rerio frankei, Cyprinus rerio, Cyprinus rerio Hamilton, 1822, Danio frankei, Danio rerio (Hamilton, 1822), Danio rerio frankei

Top Publications

  1. Fang L, Choi S, Baek J, Liu C, Almazan F, Ulrich F, et al. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 2013;498:118-22 pubmed publisher
    ..Notably, Aibp, a zebrafish homologue of human AIBP, regulates the membrane lipid order in embryonic zebrafish vasculature and functions as ..
  2. Fleming A, Diekmann H, Goldsmith P. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS ONE. 2013;8:e77548 pubmed publisher
    b>Zebrafish are becoming increasingly popular as an organism in which to model human disease and to study the effects of small molecules on complex physiological and pathological processes...
  3. Satou C, Kimura Y, Hirata H, Suster M, Kawakami K, Higashijima S. Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development. 2013;140:3927-31 pubmed publisher
    ..We generated a wide variety of transgenic zebrafish that expressed reporter genes in specific classes of neurons or neuronal progenitors...
  4. Hong E, Santhakumar K, Akitake C, Ahn S, Thisse C, Thisse B, et al. Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. Proc Natl Acad Sci U S A. 2013;110:21171-6 pubmed publisher
    ..In larval zebrafish, the bilaterally paired dorsal habenular nuclei (dHb) exhibit prominent left-right differences in their ..
  5. Nikolaev A, Leung K, Odermatt B, Lagnado L. Synaptic mechanisms of adaptation and sensitization in the retina. Nat Neurosci. 2013;16:934-41 pubmed publisher
    ..What are the circuit mechanisms underlying this plasticity? We investigated how synapses in the retina of zebrafish adjust to changes in the temporal contrast of a visual stimulus by imaging activity in vivo...
  6. MacDonald R, Pollack J, Debiais Thibaud M, Heude E, Talbot J, Ekker M. The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon. Dev Biol. 2013;381:276-85 pubmed publisher
    ..Here, we have examined the regulatory relationships between the ascl1a, dlx, and gad1b genes in the zebrafish forebrain...
  7. Yue H, Li Z, Wu N, Liu Z, Wang Y, Gui J. Oocyte-specific H2A variant H2af1o is required for cell synchrony before midblastula transition in early zebrafish embryos. Biol Reprod. 2013;89:82 pubmed publisher
    ..H2af1o, an oocyte-specific H2A variant, is required for cell synchrony before midblastula transition in early zebrafish embryos. The H2A variant is oocyte specific, peaks in mature eggs, and is supplied to early embryos...
  8. Palha N, Guivel Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, et al. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013;9:e1003619 pubmed publisher
    ..Herein we describe a novel CHIKV infection model in zebrafish, where viral spread was live-imaged in the whole body up to cellular resolution...
  9. Colombo A, Palma K, Armijo L, Mione M, Signore I, Morales C, et al. Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development. 2013;140:3997-4007 pubmed publisher
    ..as an asymmetric component of the signalling pathways leading to asymmetric morphogenesis of the habenulae in zebrafish. Daam1a is a member of the Formin family of actin-binding proteins and the extent of Daam1a expression in ..
  10. Venkiteswaran G, Lewellis S, Wang J, Reynolds E, Nicholson C, Knaut H. Generation and dynamics of an endogenous, self-generated signaling gradient across a migrating tissue. Cell. 2013;155:674-87 pubmed publisher
    ..and a signaling sensor, we analyzed the distribution of the attractant chemokine Sdf1 during migration of the zebrafish posterior lateral line primordium, a cohort of about 200 cells that migrates over a stripe of cells uniformly ..

Detail Information

Publications136 found, 100 shown here

  1. Fang L, Choi S, Baek J, Liu C, Almazan F, Ulrich F, et al. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 2013;498:118-22 pubmed publisher
    ..Notably, Aibp, a zebrafish homologue of human AIBP, regulates the membrane lipid order in embryonic zebrafish vasculature and functions as ..
  2. Fleming A, Diekmann H, Goldsmith P. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS ONE. 2013;8:e77548 pubmed publisher
    b>Zebrafish are becoming increasingly popular as an organism in which to model human disease and to study the effects of small molecules on complex physiological and pathological processes...
  3. Satou C, Kimura Y, Hirata H, Suster M, Kawakami K, Higashijima S. Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development. 2013;140:3927-31 pubmed publisher
    ..We generated a wide variety of transgenic zebrafish that expressed reporter genes in specific classes of neurons or neuronal progenitors...
  4. Hong E, Santhakumar K, Akitake C, Ahn S, Thisse C, Thisse B, et al. Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. Proc Natl Acad Sci U S A. 2013;110:21171-6 pubmed publisher
    ..In larval zebrafish, the bilaterally paired dorsal habenular nuclei (dHb) exhibit prominent left-right differences in their ..
  5. Nikolaev A, Leung K, Odermatt B, Lagnado L. Synaptic mechanisms of adaptation and sensitization in the retina. Nat Neurosci. 2013;16:934-41 pubmed publisher
    ..What are the circuit mechanisms underlying this plasticity? We investigated how synapses in the retina of zebrafish adjust to changes in the temporal contrast of a visual stimulus by imaging activity in vivo...
  6. MacDonald R, Pollack J, Debiais Thibaud M, Heude E, Talbot J, Ekker M. The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon. Dev Biol. 2013;381:276-85 pubmed publisher
    ..Here, we have examined the regulatory relationships between the ascl1a, dlx, and gad1b genes in the zebrafish forebrain...
  7. Yue H, Li Z, Wu N, Liu Z, Wang Y, Gui J. Oocyte-specific H2A variant H2af1o is required for cell synchrony before midblastula transition in early zebrafish embryos. Biol Reprod. 2013;89:82 pubmed publisher
    ..H2af1o, an oocyte-specific H2A variant, is required for cell synchrony before midblastula transition in early zebrafish embryos. The H2A variant is oocyte specific, peaks in mature eggs, and is supplied to early embryos...
  8. Palha N, Guivel Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, et al. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013;9:e1003619 pubmed publisher
    ..Herein we describe a novel CHIKV infection model in zebrafish, where viral spread was live-imaged in the whole body up to cellular resolution...
  9. Colombo A, Palma K, Armijo L, Mione M, Signore I, Morales C, et al. Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development. 2013;140:3997-4007 pubmed publisher
    ..as an asymmetric component of the signalling pathways leading to asymmetric morphogenesis of the habenulae in zebrafish. Daam1a is a member of the Formin family of actin-binding proteins and the extent of Daam1a expression in ..
  10. Venkiteswaran G, Lewellis S, Wang J, Reynolds E, Nicholson C, Knaut H. Generation and dynamics of an endogenous, self-generated signaling gradient across a migrating tissue. Cell. 2013;155:674-87 pubmed publisher
    ..and a signaling sensor, we analyzed the distribution of the attractant chemokine Sdf1 during migration of the zebrafish posterior lateral line primordium, a cohort of about 200 cells that migrates over a stripe of cells uniformly ..
  11. Weger M, Weger B, Diotel N, Rastegar S, Hirota T, Kay S, et al. Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Dev Biol. 2013;380:259-73 pubmed publisher
    ..b>Zebrafish are promising models for biomedical research due to their high regenerative capacity and suitability for in vivo ..
  12. Howarth D, Yin C, Yeh K, Sadler K. Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. Zebrafish. 2013;10:199-210 pubmed publisher
    ..We developed a series of straightforward assays to determine whether zebrafish larvae with either tunicamycin- or ethanol-induced steatosis develop hepatic dysfunction...
  13. Clemens D, Németh Cahalan K, Trinh L, Zhang T, Schilling T, Hall J. In vivo analysis of aquaporin 0 function in zebrafish: permeability regulation is required for lens transparency. Invest Ophthalmol Vis Sci. 2013;54:5136-43 pubmed publisher
    The zebrafish lens is well suited for studies of physiology and development due to its rapid formation in the embryo and genetic accessibility. Aquaporin 0 (AQP0), a lens-specific membrane protein, is required for lens clarity...
  14. Malafoglia V, Colasanti M, Raffaeli W, Balciunas D, Giordano A, Bellipanni G. Extreme thermal noxious stimuli induce pain responses in zebrafish larvae. J Cell Physiol. 2014;229:300-8 pubmed publisher
    ..We have developed a methodology in the zebrafish aimed to produce a new animal model for the study of pain induced by burns...
  15. Neugebauer J, Cadwallader A, Amack J, Bisgrove B, Yost H. Differential roles for 3-OSTs in the regulation of cilia length and motility. Development. 2013;140:3892-902 pubmed publisher
    ..We propose that individual 3-OST isozymes create distinct modified domains or 'glycocodes' on cell surface proteoglycans, which in turn regulate the response to diverse cell signaling pathways. ..
  16. Pistocchi A, Fazio G, Cereda A, Ferrari L, Bettini L, Messina G, et al. Cornelia de Lange Syndrome: NIPBL haploinsufficiency downregulates canonical Wnt pathway in zebrafish embryos and patients fibroblasts. Cell Death Dis. 2013;4:e866 pubmed publisher
    ..The present study focuses on the role of the zebrafish nipblb paralog during neural development, examining its expression in the central nervous system, and analyzing ..
  17. Lam P, Harvie E, Huttenlocher A. Heat shock modulates neutrophil motility in zebrafish. PLoS ONE. 2013;8:e84436 pubmed publisher
    ..In this study, we analyzed the impact of short-term heat shock on neutrophil function using zebrafish (Danio rerio) as an animal model...
  18. Zhang C, Frazier J, Chen H, Liu Y, Lee J, Cole G. Molecular and morphological changes in zebrafish following transient ethanol exposure during defined developmental stages. Neurotoxicol Teratol. 2014;44:70-80 pubmed publisher
    ..b>Zebrafish embryos were exposed to a range of ethanol concentrations (0.5-5...
  19. Asakawa K, Abe G, Kawakami K. Cellular dissection of the spinal cord motor column by BAC transgenesis and gene trapping in zebrafish. Front Neural Circuits. 2013;7:100 pubmed publisher
    ..Here, we applied these techniques to zebrafish (Danio rerio) in order to obtain insights into the cellular architecture of the axial motor column in vertebrates...
  20. Hunter P, Lowe A, Thompson I, Meyer M. Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity. J Neurosci. 2013;33:13940-5 pubmed publisher
    ..Using population functional calcium imaging, we aim to describe how local circuits within the zebrafish optic tectum process visual information...
  21. Schmid B, Haass C. Genomic editing opens new avenues for zebrafish as a model for neurodegeneration. J Neurochem. 2013;127:461-70 pubmed publisher
    b>Zebrafish has become a popular model organism to study human diseases...
  22. Kim J, Kang Y, Kim J, Papangeli I, Kang H, Wu J, et al. Essential role of Apelin signaling during lymphatic development in zebrafish. Arterioscler Thromb Vasc Biol. 2014;34:338-45 pubmed publisher
    ..We investigated the functions of Apelin signaling during lymphatic development using zebrafish embryos and found that attenuation of Apelin signaling substantially decreased the formation of the parachordal ..
  23. Cambier C, Takaki K, Larson R, Hernandez R, Tobin D, Urdahl K, et al. Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature. 2014;505:218-22 pubmed publisher
    ..How mycobacteria survive in these broadly microbicidal cells is an important question. Here we show in mice and zebrafish that M...
  24. Zhai G, Gu Q, He J, Lou Q, Chen X, Jin X, et al. Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development. Mol Cell Biol. 2014;34:1310-21 pubmed publisher
    ..However, the role of septins in vertebrate development remains relatively obscure. Here, we show that zebrafish septin 6 (sept6) is first expressed in the notochord and then in nearly all of the ciliary organs, including ..
  25. Kimura Y, Hisano Y, Kawahara A, Higashijima S. Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering. Sci Rep. 2014;4:6545 pubmed publisher
    ..Recently, targeted knock-in of a long DNA fragment via homology-independent DNA repair has been achieved in zebrafish using CRISPR/Cas9 system...
  26. Choorapoikayil S, Weijts B, Kers R, de Bruin A, den Hertog J. Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish. Dis Model Mech. 2013;6:1159-66 pubmed publisher
    ..tumor suppressor and has been linked to the progression of many types of tumors, including hemangiosarcomas in zebrafish. Here, we report that mutant zebrafish embryos lacking functional Pten exhibit enhanced angiogenesis, ..
  27. Lee R, Knapik E, Thiery J, Carney T. An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme. Development. 2013;140:2923-32 pubmed publisher
    ..Using genetics-based lineage tracing in zebrafish, we find that these fin mesenchyme cells derive entirely from the mesoderm and that neural crest makes no ..
  28. Hedrera M, Galdames J, Jimenez Reyes M, Reyes A, Avendaño Herrera R, Romero J, et al. Soybean meal induces intestinal inflammation in zebrafish larvae. PLoS ONE. 2013;8:e69983 pubmed publisher
    ..analyzed the effects of the ingestion of soybean meal and two of its components, soy protein and soy saponin, on zebrafish to establish the basis for using zebrafish larvae as a model for fish nutrition...
  29. Demir K, Kirsch N, Beretta C, Erdmann G, Ingelfinger D, Moro E, et al. RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Rep. 2013;4:1224-34 pubmed publisher
    ..In Xenopus laevis and Danio rerio, RAB8B morphants show lower Wnt activity during embryonic development...
  30. Kumari P, Gilligan P, Lim S, Tran L, Winkler S, Philp R, et al. An essential role for maternal control of Nodal signaling. elife. 2013;2:e00683 pubmed publisher
    ..Maternal transcripts of the zebrafish Nodal factor, Squint (Sqt), are localized to future embryonic dorsal...
  31. Ogryzko N, Hoggett E, Solaymani Kohal S, Tazzyman S, Chico T, Renshaw S, et al. Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response. Dis Model Mech. 2014;7:259-64 pubmed publisher
    ..We therefore investigated whether zebrafish embryos provide a suitable in vivo model for studying IL-1-mediated inflammation...
  32. Wang Y, Pan L, Moens C, Appel B. Notch3 establishes brain vascular integrity by regulating pericyte number. Development. 2014;141:307-17 pubmed publisher
    ..Here, we report an investigation of the Notch3 receptor using zebrafish as a model system...
  33. Duval M, Gilbert M, Watson D, Zerulla T, Tierney K, Allison W. Growth differentiation factor 6 as a putative risk factor in neuromuscular degeneration. PLoS ONE. 2014;9:e89183 pubmed publisher
    ..b>Zebrafish mutants harboring homozygous null mutations in the BMP-family gene gdf6a were raised to adulthood and assessed ..
  34. Giustiniani J, Chambraud B, Sardin E, Dounane O, Guillemeau K, Nakatani H, et al. Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy. Proc Natl Acad Sci U S A. 2014;111:4584-9 pubmed publisher
    ..EM analysis shows that Tau-P301L oligomers, induced by FKBP52, can assemble into filaments. In the transgenic zebrafish expressing the human Tau-P301L mutant, FKBP52 knockdown is sufficient to redrive defective axonal outgrowth and ..
  35. Nawaz S, Schweitzer J, Jahn O, Werner H. Molecular evolution of myelin basic protein, an abundant structural myelin component. Glia. 2013;61:1364-77 pubmed
    ..b>Zebrafish mbpb is organized in a complex transcription unit together with the unrelated gene-of-the-oligodendrocyte-..
  36. Choorapoikayil S, Kers R, Herbomel P, Kissa K, den Hertog J. Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. Blood. 2014;123:184-90 pubmed publisher
    ..We set out to investigate whether Pten is required for hematopoiesis. Analysis of zebrafish mutants lacking functional Pten revealed that HSPCs colonized the caudal hematopoietic tissue normally...
  37. Flasse L, Pirson J, Stern D, Von Berg V, Manfroid I, Peers B, et al. Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biol. 2013;11:78 pubmed publisher
    ..It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state...
  38. Karanth S, Tran V, Kuberan B, Schlegel A. Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Dis Model Mech. 2013;6:1365-77 pubmed publisher
    ..Previously we discovered that mutation of the hepatocyte β-hydroxybutyrate transporter Slc16a6a in zebrafish causes hepatic steatosis during fasting, marked by increased hepatic triacylglycerol, but not cholesterol...
  39. Austin Tse C, Halbritter J, Zariwala M, Gilberti R, Gee H, Hellman N, et al. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Am J Hum Genet. 2013;93:672-86 pubmed publisher
    ..By using zebrafish morpholino knockdown of PCD candidate genes as an in vivo screening platform, we identified c21orf59, ccdc65, ..
  40. Wong T, Tesfamichael A, Collodi P. Identification of promoter elements responsible for gonad-specific expression of zebrafish Deadend and its application to ovarian germ cell derivation. Int J Dev Biol. 2013;57:767-72 pubmed publisher
    We discovered that a 150-bp region of zebrafish deadend (dnd) spanning the translation start codon, exon 1 and part of intron 1 is required to direct heterologous neomycin-resistance gene (neo) expression specifically in the gonad, ..
  41. Subtelny A, Eichhorn S, Chen G, Sive H, Bartel D. Poly(A)-tail profiling reveals an embryonic switch in translational control. Nature. 2014;508:66-71 pubmed publisher
    ..of millions of individual RNAs isolated from yeasts, cell lines, Arabidopsis thaliana leaves, mouse liver, and zebrafish and frog embryos...
  42. Revenu C, Streichan S, Donà E, Lecaudey V, Hufnagel L, Gilmour D. Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation. Development. 2014;141:1282-91 pubmed publisher
    ..to investigate epithelial cell state transitions during collective migration and organogenesis, using the zebrafish lateral line primordium as an in vivo model...
  43. Bernut A, Herrmann J, Kissa K, Dubremetz J, Gaillard J, Lutfalla G, et al. Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation. Proc Natl Acad Sci U S A. 2014;111:E943-52 pubmed publisher
    ..Exploiting the optical transparency of zebrafish embryos, we observed that the increased virulence of the M...
  44. Wong T, Tesfamichael A, Collodi P. Production of zebrafish offspring from cultured female germline stem cells. PLoS ONE. 2013;8:e62660 pubmed publisher
    b>Zebrafish female germline stem cell (FGSC) cultures were generated from a transgenic line of fish that expresses Neo and DsRed under the control of the germ cell specific promoter, ziwi [Tg(ziwi:neo);Tg(ziwi:DsRed)]...
  45. Harvey S, Sealy I, Kettleborough R, Fényes F, White R, STEMPLE D, et al. Identification of the zebrafish maternal and paternal transcriptomes. Development. 2013;140:2703-10 pubmed publisher
    ..Although the early zebrafish embryo is competent to transcribe exogenous DNA, factors present in the embryo maintain genomic DNA in a state ..
  46. Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin Y, et al. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 2013;498:497-501 pubmed publisher
    ..Here we have developed, in the zebrafish (Danio rerio), a combination of fluorescent reporter transgenes, genetic fate-mapping strategies and a ventricle-specific ..
  47. O Donnell K, Vargas M, Sagasti A. WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury. J Neurosci. 2013;33:14778-90 pubmed publisher
    ..Using cutaneous sensory neurons of living larval zebrafish as a model, we examined the role of mitochondria in axon degeneration by monitoring mitochondrial morphology, ..
  48. Shiau C, Monk K, Joo W, Talbot W. An anti-inflammatory NOD-like receptor is required for microglia development. Cell Rep. 2013;5:1342-52 pubmed publisher
    ..Starting with a genetic screen in zebrafish, we show that the noncanonical NOD-like receptor (NLR) nlrc3-like is essential for microglial formation...
  49. Yadav G, Chakraborty A, Uechi T, Kenmochi N. Ribosomal protein deficiency causes Tp53-independent erythropoiesis failure in zebrafish. Int J Biochem Cell Biol. 2014;49:1-7 pubmed publisher
    ..down five RP genes (two Diamond-Blackfan anemia-associated and three non-Diamond-Blackfan anemia-associated) in zebrafish and analyzed the effects on the developmental and erythroid phenotypes in the presence and absence of Tp53...
  50. Dreosti E, Vendrell Llopis N, Carl M, Yaksi E, Wilson S. Left-right asymmetry is required for the habenulae to respond to both visual and olfactory stimuli. Curr Biol. 2014;24:440-5 pubmed publisher
    ..Here we show that sensory responses to light and odor are lateralized in larval zebrafish habenulae and that loss of brain asymmetry leads to concomitant loss of responsiveness to either visual or ..
  51. Sacilotto N, Monteiro R, Fritzsche M, Becker P, Sánchez del Campo L, Liu K, et al. Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development. Proc Natl Acad Sci U S A. 2013;110:11893-8 pubmed publisher
    ..Using both mouse and zebrafish models, we demonstrate here that arterial specification is regulated combinatorially by Notch signaling and SoxF ..
  52. Wythe J, Dang L, Devine W, Boudreau E, Artap S, He D, et al. ETS factors regulate Vegf-dependent arterial specification. Dev Cell. 2013;26:45-58 pubmed publisher
    ....
  53. Iglesias A, Springelkamp H, van der Linde H, Severijnen L, Amin N, Oostra B, et al. Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Hum Mol Genet. 2014;23:1320-32 pubmed publisher
    ..Functional characterization of SIX6 in zebrafish revealed that knockdown of six6b led to a small eye phenotype...
  54. Elks P, Brizee S, van der Vaart M, Walmsley S, van Eeden F, Renshaw S, et al. Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog. 2013;9:e1003789 pubmed publisher
    ..We sought to manipulate Hif-α signaling in a well-established Mycobacterium marinum (Mm) zebrafish model of TB to investigate effects on the host's ability to combat mycobacterial infection...
  55. Kanther M, Tomkovich S, Xiaolun S, Grosser M, Koo J, Flynn E, et al. Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. Cell Microbiol. 2014;16:1053-67 pubmed publisher
    ..Here we utilized in vivo imaging in gnotobiotic zebrafish to reveal diverse effects of microbiota colonization on systemic neutrophil development and function...
  56. Soroldoni D, Jörg D, Morelli L, Richmond D, Schindelin J, Jülicher F, et al. Genetic oscillations. A Doppler effect in embryonic pattern formation. Science. 2014;345:222-5 pubmed publisher
    ..However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation...
  57. deCarvalho T, Akitake C, Thisse C, Thisse B, Halpern M. Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish. Front Neural Circuits. 2013;7:98 pubmed publisher
    The dorsal habenular nuclei of the zebrafish epithalamus have become a valuable model for studying the development of left-right (L-R) asymmetry and its function in the vertebrate brain...
  58. Kamel G, Hoyos T, Rochard L, Dougherty M, Kong Y, Tse W, et al. Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis. Dev Biol. 2013;381:423-33 pubmed publisher
    ..lower jaw structures, and integration of wnt-frizzled with endothelin signaling to coordinate shaping of the facial form. ..
  59. Hogstrand C, Kille P, Ackland M, Hiscox S, Taylor K. A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3). Biochem J. 2013;455:229-37 pubmed publisher
    ..ZIP6 [SLC39A6; solute carrier family 39 (zinc transporter), member 6; also known as LIV-1) was linked to EMT in zebrafish gastrulation through a STAT3 (signal transducer and activator of transcription 3) mechanism, resulting in ..
  60. Balow S, Pierce L, Zentner G, Conrad P, Davis S, Sabaawy H, et al. Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome. Dev Biol. 2013;382:57-69 pubmed publisher
    ..To examine the role of Chd7 in development, a zebrafish model was generated through morpholino (MO)-mediated targeting of the zebrafish chd7 transcript...
  61. Suzuki S, Bleckert A, Williams P, Takechi M, Kawamura S, Wong R. Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors. Proc Natl Acad Sci U S A. 2013;110:15109-14 pubmed publisher
    ..The modes of cell division generating distinct cone types are unknown. We report here a mechanism whereby zebrafish cone photoreceptors of the same type are produced by symmetric division of dedicated precursors...
  62. Hamada H, Watanabe M, Lau H, Nishida T, Hasegawa T, Parichy D, et al. Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. Development. 2014;141:318-24 pubmed publisher
    The skin pigment pattern of zebrafish is a good model system in which to study the mechanism of biological pattern formation...
  63. Zhao L, Borikova A, Ben Yair R, Guner Ataman B, Macrae C, Lee R, et al. Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2014;111:1403-8 pubmed publisher
    ..Remarkably, certain vertebrate species, including the zebrafish, achieve complete regeneration of amputated or injured myocardium through the proliferation of spared ..
  64. Ou Z, Yin L, Chang C, Peng J, Chen J. Protein interaction between p53 and Δ113p53 is required for the anti-apoptotic function of Δ113p53. J Genet Genomics. 2014;41:53-62 pubmed publisher
    b>Zebrafish Δ113p53, an N-terminal truncated p53 isoform, is a p53-target gene that antagonises p53-mediated apoptotic activity...
  65. Maharana J, Patra M, De B, Sahoo B, Behera B, De S, et al. Structural insights into the MDP binding and CARD-CARD interaction in zebrafish (Danio rerio) NOD2: a molecular dynamics approach. J Mol Recognit. 2014;27:260-75 pubmed publisher
    ..Herein, we have predicted the probable MDP and CARD-CARD binding surfaces in zebrafish NOD2 (zNOD2) using various in silico methodologies...
  66. Maharana J, Sahoo B, Bej A, Patra M, Dehury B, Bhoi G, et al. Structural and functional investigation of zebrafish (Danio rerio) NOD1 leucine rich repeat domain and its interaction with iE-DAP. Mol Biosyst. 2014;10:2942-53 pubmed publisher
    ..Herein, we modeled 3D structure of zebrafish NOD1-LRR (zNOD1-LRR) through a protein-threading approach and structural integrity of the model was assessed ..
  67. Mahalwar P, Walderich B, Singh A, NUSSLEIN VOLHARD C. Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish. Science. 2014;345:1362-4 pubmed publisher
    The pattern of alternating blue and golden stripes displayed by adult zebrafish is composed of three kinds of pigment cells: black melanophores, yellow xanthophores, and silvery-blue iridophores...
  68. Weicksel S, Xu J, SAGERSTROM C. Dynamic nucleosome organization at hox promoters during zebrafish embryogenesis. PLoS ONE. 2013;8:e63175 pubmed publisher
    ..Using four stages of early embryonic zebrafish development, we map nucleosome positions at the promoter region of 37 zebrafish hox genes...
  69. Aoki T, Kinoshita M, Aoki R, Agetsuma M, Aizawa H, Yamazaki M, et al. Imaging of neural ensemble for the retrieval of a learned behavioral program. Neuron. 2013;78:881-94 pubmed publisher
    ..We trained zebrafish in aversive reinforcement learning and measured calcium signals across their entire brain during retrieval of ..
  70. Liu Y, Xu X, Chen Q, Wang T, Deng C, Song B, et al. Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Nat Commun. 2013;4:2005 pubmed publisher
    ..Furthermore, the MYO5B-Rab10 system is required for axon development of vertebrate neocortical neurons or zebrafish retinal ganglion cells in vivo...
  71. zhan G, Sezgin E, Wehner D, Pfister A, K hl S, Kagermeier Schenk B, et al. Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev Cell. 2013;26:331-45 pubmed publisher
    ..lypd6 enhances Wnt signaling in zebrafish and Xenopus embryos and in mammalian cells, and it is required for wnt8-mediated patterning of the mesoderm and ..
  72. Moore R, Theveneau E, Pozzi S, Alexandre P, Richardson J, Merks A, et al. Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion. Development. 2013;140:4763-75 pubmed publisher
    ..We show in Xenopus and zebrafish that Par3 is localised to the cell-cell contact in neural crest cells and is essential for CIL...
  73. Ivanovitch K, Cavodeassi F, Wilson S. Precocious acquisition of neuroepithelial character in the eye field underlies the onset of eye morphogenesis. Dev Cell. 2013;27:293-305 pubmed publisher
    Using high-resolution live imaging in zebrafish, we show that presumptive eye cells acquire apicobasal polarity and adopt neuroepithelial character prior to other regions of the neural plate...
  74. Bräutigam L, Jensen L, Poschmann G, Nyström S, Bannenberg S, Dreij K, et al. Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Proc Natl Acad Sci U S A. 2013;110:20057-62 pubmed publisher
    ..time-lapse studies based on two-photon microscopy revealed that morpholino-based knockdown of glutaredoxin 2 in zebrafish, a model organism to study vertebrate embryogenesis, resulted in a delayed and disordered blood vessel network...
  75. Perathoner S, Daane J, Henrion U, Seebohm G, Higdon C, Johnson S, et al. Bioelectric signaling regulates size in zebrafish fins. PLoS Genet. 2014;10:e1004080 pubmed publisher
    ..The zebrafish another longfin (alf) mutant shows allometric growth resulting in proportionally enlarged fins and barbels...
  76. Flentke G, Klingler R, Tanguay R, Carvan M, Smith S. An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. Alcohol Clin Exp Res. 2014;38:1255-65 pubmed publisher
    ..Nonhuman animal models offer novel insights into its underlying mechanisms. Although the developing zebrafish has great promise for FASD research, a significant challenge to its wider adoption is the paucity of clear, ..
  77. Patterson L, Parichy D. Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. PLoS Genet. 2013;9:e1003561 pubmed publisher
    ..fundamental mechanisms of morphogenesis, differentiation, and pattern formation, and recent studies of zebrafish have started to elucidate the cellular interactions and molecular mechanisms underlying these processes...
  78. Li X, Ma J, Fang Q, Li Y. Transcription alterations of microRNAs, cytochrome P4501A1 and 3A65, and AhR and PXR in the liver of zebrafish exposed to crude microcystins. Toxicon. 2013;73:17-22 pubmed publisher
    ..aryl hydrocarbon receptor (AhR, for CYP1A1) and pregnane X receptor (PXR, for CYP3A65), in the liver of zebrafish were evaluated after 24 h of 50, 200, or 800 μg/L of crude MCs exposure by using the quantitative real-time ..
  79. Liu X, Wang H, Li G, Huang H, Wang Y. The function of DrPax1b gene in the embryonic development of zebrafish. Genes Genet Syst. 2013;88:261-9 pubmed
    ..In zebrafish, the genome contains two Pax1 paralogs, DrPax1a and DrPax1b, which share high sequence similarity with other ..
  80. Potok M, Nix D, Parnell T, Cairns B. Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern. Cell. 2013;153:759-72 pubmed publisher
    ..To understand this process, we determined the DNA methylation (DNAme) profiles of zebrafish gametes, embryos at different stages, and somatic muscle and compared them to gene activity and histone ..
  81. Peterson S, Zhang J, Freeman J. Developmental reelin expression and time point-specific alterations from lead exposure in zebrafish. Neurotoxicol Teratol. 2013;38:53-60 pubmed publisher
    ..In a previous study utilizing developing zebrafish, the RELN ortholog was in a subset of genes associated with neuronal function that was altered following ..
  82. Kou I, Takahashi Y, Johnson T, Takahashi A, Guo L, Dai J, et al. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis. Nat Genet. 2013;45:676-9 pubmed publisher
    ..27 × 10(-14); OR = 1.27). GPR126 was highly expressed in cartilage, and the knockdown of gpr126 in zebrafish caused delayed ossification of the developing spine...
  83. Kishimoto N, Asakawa K, Madelaine R, Blader P, Kawakami K, Sawamoto K. Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain. Nat Neurosci. 2013;16:884-8 pubmed publisher
    ..We performed gene-trap screens in adult zebrafish to identify genes that are differentially expressed in the two hemispheres and found that adult-born neurons ..
  84. Filipek Gorniok B, Holmborn K, Haitina T, Habicher J, Oliveira M, Hellgren C, et al. Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development. Dev Dyn. 2013;242:964-75 pubmed publisher
    ..Here we show that one of these genes, chpf, is represented by two copies in the zebrafish genome, chpfa and chpfb, while the other five human CS/DS glycosyltransferases csgalnact1, csgalnact2, chpf2, ..
  85. Banjo T, Grajcarek J, Yoshino D, Osada H, Miyasaka K, Kida Y, et al. Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21. Nat Commun. 2013;4:1978 pubmed publisher
    ..Here we use a zebrafish model to show that the microRNA, miR-21, is crucial for regulation of heart valve formation...
  86. Ninov N, Hesselson D, Gut P, Zhou A, Fidelin K, Stainier D. Metabolic regulation of cellular plasticity in the pancreas. Curr Biol. 2013;23:1242-50 pubmed publisher
    ..Furthermore, using a new zebrafish line where β cells are constitutively ablated, we show that β cell loss and high nutrient intake ..
  87. Watson O, Novodvorsky P, Gray C, Rothman A, Lawrie A, Crossman D, et al. Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling. Cardiovasc Res. 2013;100:252-61 pubmed publisher
    ..Developing zebrafish (Danio rerio) embryos survive via diffusion in the absence of circulation induced by knockdown of cardiac troponin T2 or ..
  88. De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong B, Cantelmo A, et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013;154:651-63 pubmed publisher
    ....
  89. Nachtrab G, Kikuchi K, Tornini V, Poss K. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development. 2013;140:3754-64 pubmed publisher
    ..Here, we investigated potential regulators of anteroposterior (AP) pattern during fin regeneration in adult zebrafish. Sequence-based profiling from tissues along the AP axis of uninjured pectoral fins identified many genes with ..
  90. Mostowy S, Boucontet L, Mazon Moya M, Sirianni A, Boudinot P, Hollinshead M, et al. The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy. PLoS Pathog. 2013;9:e1003588 pubmed publisher
    ..However, the role of bacterial autophagy in vivo remains poorly understood. The zebrafish (Danio rerio) has emerged as a vertebrate model for the study of infections because it is optically accessible at the larval ..
  91. Brothers K, Gratacap R, Barker S, Newman Z, Norum A, Wheeler R. NADPH oxidase-driven phagocyte recruitment controls Candida albicans filamentous growth and prevents mortality. PLoS Pathog. 2013;9:e1003634 pubmed publisher
    ..and clinically important fungal pathogen that grows as both yeast and hyphal forms during human, mouse and zebrafish infection...
  92. Choi T, Ninov N, Stainier D, Shin D. Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. Gastroenterology. 2014;146:776-88 pubmed publisher
    ..To investigate this issue, we established a zebrafish model of liver regeneration in which the extent of hepatocyte ablation can be controlled.
  93. Wang X, Robertson A, Li J, Chai R, Haishan W, Sadiku P, et al. Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Dis Model Mech. 2014;7:163-9 pubmed publisher
    ..Here we describe the use of an in vivo model - the Tg(mpx:GFP)(i114) zebrafish line, in which neutrophils are labelled by green fluorescent protein (GFP) - to screen a natural product library ..
  94. Miyares R, Stein C, Renisch B, Anderson J, Hammerschmidt M, Farber S. Long-chain Acyl-CoA synthetase 4A regulates Smad activity and dorsoventral patterning in the zebrafish embryo. Dev Cell. 2013;27:635-47 pubmed publisher
    ..acyl-CoA synthetase 4a (Acsl4a), an LC-PUFA activating enzyme, is essential for proper patterning of the zebrafish dorsoventral axis...
  95. Mathias J, Zhang Z, Saxena M, Mumm J. Enhanced cell-specific ablation in zebrafish using a triple mutant of Escherichia coli nitroreductase. Zebrafish. 2014;11:85-97 pubmed publisher
    ..In zebrafish, the NTR system enables studies of cell function and cellular regeneration...
  96. Wang T, Holzhausen L, Kramer R. Imaging an optogenetic pH sensor reveals that protons mediate lateral inhibition in the retina. Nat Neurosci. 2014;17:262-8 pubmed publisher
    ..Using zebrafish retinas, we show that light elicits a change in synaptic proton concentration with the correct magnitude, ..
  97. Calzolari S, Terriente J, Pujades C. Cell segregation in the vertebrate hindbrain relies on actomyosin cables located at the interhombomeric boundaries. EMBO J. 2014;33:686-701 pubmed publisher
    ..Here, we demonstrate that in the hindbrain of zebrafish embryos cell sorting sharpens the molecular boundaries and, once borders are straight, actomyosin barriers are ..
  98. Garric L, Ronsin B, Roussigne M, Booton S, Gamse J, Dufourcq P, et al. Pitx2c ensures habenular asymmetry by restricting parapineal cell number. Development. 2014;141:1572-9 pubmed publisher
    ..Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus...
  99. Wasfy M, Matsui J, Miller J, Dowling J, Perkins B. myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses. Exp Eye Res. 2014;122:65-76 pubmed publisher
    ..Previous studies of the zebrafish mariner mutant, which also carries a mutation in myo7aa, revealed balance and hearing defects in the mutants but ..
  100. Eno C, Pelegri F. Gradual recruitment and selective clearing generate germ plasm aggregates in the zebrafish embryo. Bioarchitecture. 2013;3:125-32 pubmed publisher
    ..In many species, PGCs are determined through maternally-inherited germ plasm ribonucleoparticles (RNPs). In zebrafish, these are transmitted during oogenesis as dispersed RNPs, which after fertilization multimerize and become ..
  101. Gagnon J, Valen E, Thyme S, Huang P, Akhmetova L, Ahkmetova L, et al. Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs. PLoS ONE. 2014;9:e98186 pubmed publisher
    ..To uncover the rules that govern effective Cas9-mediated mutagenesis in zebrafish, we targeted over a hundred genomic loci for mutagenesis using a streamlined and cloning-free method...