common platanna

Summary

Alias: platanna, African clawed frog, clawed frog, Xenopus laevis, Xenopus leavis, Bufo laevis, Xenopus laevis (Daudin, 1802)

Top Publications

  1. Loughlin R, Wilbur J, McNally F, N d lec F, Heald R. Katanin contributes to interspecies spindle length scaling in Xenopus. Cell. 2011;147:1397-407 pubmed publisher
    ..Thus, mechanisms have evolved in different species to scale spindle size and coordinate regulation of multiple MT populations in order to generate a robust steady-state structure...
  2. Revinski D, Paganelli A, Carrasco A, López S. Delta-Notch signaling is involved in the segregation of the three germ layers in Xenopus laevis. Dev Biol. 2010;339:477-92 pubmed publisher
    ..Moreover, Notch activity must be modulated at appropriate levels during this process in order to keep normal morphogenetic movements during gastrulation...
  3. Klos Dehring D, Vladar E, Werner M, Mitchell J, Hwang P, Mitchell B. Deuterosome-mediated centriole biogenesis. Dev Cell. 2013;27:103-12 pubmed publisher
    ..However, in CCDC78 morphants, Cep152 fails to localize to the deuterosome and centriole biogenesis is impaired, indicating that CCDC78-mediated recruitment of Cep152 is required for deuterosome-mediated centriole biogenesis. ..
  4. Elkouby Y, Elias S, Casey E, Blythe S, Tsabar N, Klein P, et al. Mesodermal Wnt signaling organizes the neural plate via Meis3. Development. 2010;137:1531-41 pubmed publisher
    ..This suggests a new model for neural anteroposterior patterning, in which Wnt3a from the paraxial mesoderm induces posterior cell fates via direct activation of a crucial transcription factor in the overlying neural plate...
  5. Knipscheer P, Raschle M, Smogorzewska A, Enoiu M, Ho T, SCHARER O, et al. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science. 2009;326:1698-701 pubmed publisher
    ..Reversal of these defects requires ubiquitylated FANCI-FANCD2. Our results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is compromised...
  6. Levy D, Heald R. Nuclear size is regulated by importin α and Ntf2 in Xenopus. Cell. 2010;143:288-98 pubmed publisher
    ..We investigated nuclear scaling in the pseudotetraploid frog Xenopus laevis and its smaller diploid relative Xenopus tropicalis, which contains smaller cells and nuclei...
  7. Hao H, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012;485:195-200 pubmed publisher
    ..These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3. Our study provides new mechanistic insights into the regulation of Wnt receptor turnover, and reveals ZNRF3 as a tractable target for therapeutic exploration...
  8. Cousin H, Abbruzzese G, McCusker C, Alfandari D. ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis. Dev Biol. 2012;368:335-44 pubmed publisher
    ..Together our results suggest that ADAM13 changes CNC interaction with the extracellular environment and that this change is necessary for their migration in vivo...
  9. Kim K, Lake B, Haremaki T, Weinstein D, Sokol S. Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis. Dev Dyn. 2012;241:1385-95 pubmed publisher
    ..As Rab11-dependent vesicle trafficking has been implicated in ciliary membrane assembly and in apical domain formation in epithelial cells, we assessed the involvement of Rab11 in MCC development...
  10. Wen L, Yang Y, Wang Y, Xu A, Wu D, Chen Y. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Dev Dyn. 2010;239:2198-207 pubmed publisher
    ..Together, our data suggest that appl1-akt signaling is specifically required for the survival of pancreas and SD progenitor cells in Xenopus laevis embryos.

Detail Information

Publications87

  1. Loughlin R, Wilbur J, McNally F, N d lec F, Heald R. Katanin contributes to interspecies spindle length scaling in Xenopus. Cell. 2011;147:1397-407 pubmed publisher
    ..Thus, mechanisms have evolved in different species to scale spindle size and coordinate regulation of multiple MT populations in order to generate a robust steady-state structure...
  2. Revinski D, Paganelli A, Carrasco A, López S. Delta-Notch signaling is involved in the segregation of the three germ layers in Xenopus laevis. Dev Biol. 2010;339:477-92 pubmed publisher
    ..Moreover, Notch activity must be modulated at appropriate levels during this process in order to keep normal morphogenetic movements during gastrulation...
  3. Klos Dehring D, Vladar E, Werner M, Mitchell J, Hwang P, Mitchell B. Deuterosome-mediated centriole biogenesis. Dev Cell. 2013;27:103-12 pubmed publisher
    ..However, in CCDC78 morphants, Cep152 fails to localize to the deuterosome and centriole biogenesis is impaired, indicating that CCDC78-mediated recruitment of Cep152 is required for deuterosome-mediated centriole biogenesis. ..
  4. Elkouby Y, Elias S, Casey E, Blythe S, Tsabar N, Klein P, et al. Mesodermal Wnt signaling organizes the neural plate via Meis3. Development. 2010;137:1531-41 pubmed publisher
    ..This suggests a new model for neural anteroposterior patterning, in which Wnt3a from the paraxial mesoderm induces posterior cell fates via direct activation of a crucial transcription factor in the overlying neural plate...
  5. Knipscheer P, Raschle M, Smogorzewska A, Enoiu M, Ho T, SCHARER O, et al. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science. 2009;326:1698-701 pubmed publisher
    ..Reversal of these defects requires ubiquitylated FANCI-FANCD2. Our results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is compromised...
  6. Levy D, Heald R. Nuclear size is regulated by importin α and Ntf2 in Xenopus. Cell. 2010;143:288-98 pubmed publisher
    ..We investigated nuclear scaling in the pseudotetraploid frog Xenopus laevis and its smaller diploid relative Xenopus tropicalis, which contains smaller cells and nuclei...
  7. Hao H, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012;485:195-200 pubmed publisher
    ..These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3. Our study provides new mechanistic insights into the regulation of Wnt receptor turnover, and reveals ZNRF3 as a tractable target for therapeutic exploration...
  8. Cousin H, Abbruzzese G, McCusker C, Alfandari D. ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis. Dev Biol. 2012;368:335-44 pubmed publisher
    ..Together our results suggest that ADAM13 changes CNC interaction with the extracellular environment and that this change is necessary for their migration in vivo...
  9. Kim K, Lake B, Haremaki T, Weinstein D, Sokol S. Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis. Dev Dyn. 2012;241:1385-95 pubmed publisher
    ..As Rab11-dependent vesicle trafficking has been implicated in ciliary membrane assembly and in apical domain formation in epithelial cells, we assessed the involvement of Rab11 in MCC development...
  10. Wen L, Yang Y, Wang Y, Xu A, Wu D, Chen Y. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Dev Dyn. 2010;239:2198-207 pubmed publisher
    ..Together, our data suggest that appl1-akt signaling is specifically required for the survival of pancreas and SD progenitor cells in Xenopus laevis embryos.
  11. Kerstein P, Jacques Fricke B, Rengifo J, Mogen B, Williams J, Gottlieb P, et al. Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci. 2013;33:273-85 pubmed publisher
    ..Together our results suggest that Ca(2+) influx through MS TRPC1 on filopodia activates calpain to control growth cone turning during development...
  12. Konno N, Fujii Y, Imae H, Kaiya H, Mukuda T, Miyazato M, et al. Urotensin II receptor (UTR) exists in hyaline chondrocytes: a study of peripheral distribution of UTR in the African clawed frog, Xenopus laevis. Gen Comp Endocrinol. 2013;185:44-56 pubmed publisher
    ..elucidating the actions of UII and URP in amphibians, we cloned and characterized URP and UTR from the African clawed frog Xenopus laevis...
  13. Lander R, Nasr T, Ochoa S, Nordin K, Prasad M, LaBonne C. Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation. Nat Commun. 2013;4:1542 pubmed publisher
    ..Together, these findings elucidate a mechanism for coordinated control of a group of structurally diverse factors that function as a regulatory unit in both developmental and pathological epithelial-mesenchymal transitions...
  14. Reber S, Baumgart J, Widlund P, Pozniakovsky A, Howard J, Hyman A, et al. XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules. Nat Cell Biol. 2013;15:1116-22 pubmed publisher
    ..engineering the enzymatic activity of XMAP215, a processive microtubule polymerase, we show that Xenopus laevis spindle length increases linearly with microtubule growth velocity, whereas other parameters of spindle ..
  15. Drinjakovic J, Jung H, Campbell D, Strochlic L, Dwivedy A, Holt C. E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron. 2010;65:341-57 pubmed publisher
    ..Together our data suggest that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo...
  16. Moore R, Theveneau E, Pozzi S, Alexandre P, Richardson J, Merks A, et al. Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion. Development. 2013;140:4763-75 pubmed publisher
    ..Our results demonstrate a novel role of Par3 during neural crest migration, which is likely to be conserved in other processes that involve CIL such as cancer invasion or cell dispersion...
  17. Ouyang M, Lu S, Kim T, Chen C, Seong J, Leckband D, et al. N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways. Nat Commun. 2013;4:1589 pubmed publisher
    ..We hence conclude that N-cadherin couples with distinct effectors to polarize phosphoinositide 3-kinase/Rac and myosin II light chain/actin filaments in migrating cells...
  18. Barriga E, Maxwell P, Reyes A, Mayor R. The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition. J Cell Biol. 2013;201:759-76 pubmed publisher
    ..Inhibition of Hif-1α by antisense morpholinos in Xenopus laevis or zebrafish embryos led to complete inhibition of neural crest migration...
  19. Law A, Vehlow A, Kotini M, Dodgson L, Soong D, Theveneau E, et al. Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J Cell Biol. 2013;203:673-89 pubmed publisher
    ..Consistently, Lpd regulates mesenchymal neural crest cell migration cell autonomously in Xenopus laevis via the Scar/WAVE complex...
  20. Park B, Saint Jeannet J. Expression analysis of Runx3 and other Runx family members during Xenopus development. Gene Expr Patterns. 2010;10:159-66 pubmed publisher
    ..These observations suggest a critical role for Runx3 in the development of cranial sensory neurons, while in other tissues its co-expression with Runx1 or Runx2 may signify functional redundancy between these family members. ..
  21. Zyłkiewicz E, Kijanska M, Choi W, Derewenda U, Derewenda Z, Stukenberg P. The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein. J Cell Biol. 2011;192:433-45 pubmed publisher
    ..Together, our results provide important insights into how Ndel1 acts as a regulated scaffold to temporally and spatially regulate dynein. ..
  22. Gutkovich Y, Ofir R, Elkouby Y, Dibner C, Gefen A, Elias S, et al. Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development. Dev Biol. 2010;338:50-62 pubmed publisher
    ..Thus, XMeis3 protein is positioned at a key regulatory point, simultaneously regulating multiple neural cell fates during early vertebrate nervous system development. ..
  23. Pearl E, Jarikji Z, Horb M. Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes. Dev Biol. 2011;351:135-45 pubmed publisher
    ..In early development Rfx6 plays a broad role, being essential for development of most anterior endodermal organs. At later stages however, Rfx6 function is restricted to endocrine cells. ..
  24. Tandon P, Miteva Y, Kuchenbrod L, Cristea I, Conlon F. Tcf21 regulates the specification and maturation of proepicardial cells. Development. 2013;140:2409-21 pubmed publisher
    ..Collectively, these studies lead us to propose that Tcf21 functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium. ..
  25. Lowery L, Stout A, Faris A, Ding L, Baird M, Davidson M, et al. Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth. Neural Dev. 2013;8:22 pubmed publisher
    ..we use quantitative analysis of high-resolution live imaging to examine the function of XMAP215 in embryonic Xenopus laevis neurons...
  26. Fujimoto K, Matsuura K, Hu Wang E, Lu R, Shi Y. Thyroid hormone activates protein arginine methyltransferase 1 expression by directly inducing c-Myc transcription during Xenopus intestinal stem cell development. J Biol Chem. 2012;287:10039-50 pubmed publisher
    ..These results suggest that T3 induces c-Myc transcription directly in the intestine, that c-Myc, in turn, activates PRMT1 expression, and that this is an important gene regulation cascade controlling intestinal stem cell development. ..
  27. Wang S, Zheng Y. Identification of a novel dynein binding domain in nudel essential for spindle pole organization in Xenopus egg extract. J Biol Chem. 2011;286:587-93 pubmed publisher
    ..Together, our findings open up new avenues to further decipher the mechanism of dynein regulation by Nudel and Lis1. ..
  28. Wilczek C, Chitta R, Woo E, Shabanowitz J, Chait B, Hunt D, et al. Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs. J Biol Chem. 2011;286:42221-31 pubmed publisher
    ..In the maturing oocytes and eggs of the frog Xenopus laevis, histones are synthesized in bulk in preparation for deposition during the rapid early developmental cell ..
  29. Labit H, Fujimitsu K, Bayin N, Takaki T, Gannon J, Yamano H. Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C. EMBO J. 2012;31:3351-62 pubmed publisher
    ..Furthermore, we show that the 'activation domain' of Cdc20 associates with the Apc6 and Apc8 core subunits. Our data suggest that dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase. ..
  30. Lorca T, Bernis C, Vigneron S, Burgess A, Brioudes E, Labbé J, et al. Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle. J Cell Sci. 2010;123:2281-91 pubmed publisher
    ....
  31. Leblanc J, Zhang X, McKee D, Wang Z, Li R, Ma C, et al. The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization. Mol Hum Reprod. 2011;17:305-16 pubmed publisher
    ..Therefore, Cdc42 activation likely promotes membrane protrusion during polar body emission in widespread systems. ..
  32. Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, et al. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development. 2014;141:2216-24 pubmed publisher
    ....
  33. Jung B, Köhler A, Schambony A, Wedlich D. PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus. BMC Dev Biol. 2011;11:36 pubmed publisher
    ....
  34. Ramirez Gordillo D, Trujillo Provencio C, Knight V, Serrano E. Optimization of gene delivery methods in Xenopus laevis kidney (A6) and Chinese hamster ovary (CHO) cell lines for heterologous expression of Xenopus inner ear genes. In Vitro Cell Dev Biol Anim. 2011;47:640-52 pubmed publisher
    ..Our findings demonstrate the need to improve gene delivery methods for amphibian cells and underscore the necessity for a greater understanding of amphibian cell biology. ..
  35. Kuriyama S, Theveneau E, Benedetto A, Parsons M, Tanaka M, Charras G, et al. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. J Cell Biol. 2014;206:113-27 pubmed publisher
    ..This change of plasticity allows cells to migrate under physical constraints without abolishing cell cooperation required for collectiveness. ..
  36. Suzuki M, Hara Y, Takagi C, Yamamoto T, Ueno N. MID1 and MID2 are required for Xenopus neural tube closure through the regulation of microtubule organization. Development. 2010;137:2329-39 pubmed publisher
    ..We propose that similar MID-governed mechanisms underlie the normal morphogenesis of epithelial tissues and organs, including the tissues affected in patients with Opitz G/BBB syndrome. ..
  37. Wawrousek K, Fortini B, Polaczek P, Chen L, Liu Q, Dunphy W, et al. Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. Cell Cycle. 2010;9:1156-66 pubmed
    We have used the Xenopus laevis egg extract system to study the roles of vertebrate Dna2 in DNA replication and double-strand-break (DSB) repair.  We first establish that Xenopus Dna2 is a helicase, as well as a nuclease...
  38. Poh W, Chadha G, Gillespie P, Kaldis P, Blow J. Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol. 2014;4:130138 pubmed publisher
    ....
  39. Hashimoto Y, Puddu F, Costanzo V. RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol. 2011;19:17-24 pubmed publisher
    ..These results show that, in higher eukaryotes, replisomes are partially dismantled after fork collapse and fully re-established by a recombination-mediated process. ..
  40. Schweickert A, Vick P, Getwan M, Weber T, Schneider I, Eberhardt M, et al. The nodal inhibitor Coco is a critical target of leftward flow in Xenopus. Curr Biol. 2010;20:738-43 pubmed publisher
    ..Coco thus acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline. ..
  41. Ryu H, Al Ani G, Deckert K, Kirkpatrick D, Gygi S, Dasso M, et al. PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes. J Biol Chem. 2010;285:14415-23 pubmed publisher
    ..However, loss of SUMOylation increased PARP1-dependent PARylation on isolated chromosomes, indicating SUMOylation controls the capacity of PARP1 to modify other chromatin-associated proteins. ..
  42. Tadjuidje E, Cha S, Louza M, Wylie C, Heasman J. The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo. Dev Dyn. 2011;240:1727-36 pubmed publisher
    Of the three Dishevelled (Dvl) genes, only Dvl2 and Dvl3 are maternally encoded in the frog, Xenopus laevis. We show here by loss of function analysis that single depletion of either Dvl2 or Dvl3 from the oocyte causes the same embryonic ..
  43. Tam J, Lau K, Lee L, Chu J, Ng K, Fournier A, et al. Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin. PLoS ONE. 2011;6:e19384 pubmed publisher
    ..We therefore hypothesize that secretin and orexin are of different ancestral origins early in the vertebrate lineage. ..
  44. Fonar Y, Gutkovich Y, Root H, Malyarova A, Aamar E, Golubovskaya V, et al. Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate. Mol Biol Cell. 2011;22:2409-21 pubmed publisher
    ..However, little is known about its normal embryonic function. FAK protein knockdown during early Xenopus laevis development anteriorizes the embryo...
  45. Miyamoto K, Pasque V, Jullien J, Gurdon J. Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Genes Dev. 2011;25:946-58 pubmed publisher
    ..This is the first report showing that naturally stored actin in an oocyte nucleus helps transcriptional reprogramming in a polymerization-dependent manner. ..
  46. Becker S, Mayor R, Kashef J. Cadherin-11 mediates contact inhibition of locomotion during Xenopus neural crest cell migration. PLoS ONE. 2013;8:e85717 pubmed publisher
    ..Blocking Wnt/PCP signaling led to similar results underlining the importance of Xcad-11 in the mechanism of CIL and directional migration of CNC. ..
  47. Lee J, Dunphy W. Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks. Mol Biol Cell. 2010;21:926-35 pubmed publisher
    ..First, Rad17 loads 9-1-1 onto DNA. Second, TopBP1 accumulates on chromatin in a manner that depends on both Rad17 and 9-1-1. Finally, 9-1-1 and TopBP1 dock in a Rad17-dependent manner before activation of Chk1. ..
  48. Wang Y, Mukhopadhyay D, Mathew S, Hasebe T, Heimeier R, Azuma Y, et al. Identification and developmental expression of Xenopus laevis SUMO proteases. PLoS ONE. 2009;4:e8462 pubmed publisher
    ..how Ulp/SENPs are regulated in a developmental context, we isolated and characterized all Ulp/SENPs in Xenopus laevis. Xenopus possess homologues of mammalian SENP3, 5, 6 and 7...
  49. Wilbur J, Heald R. Mitotic spindle scaling during Xenopus development by kif2a and importin α. elife. 2013;2:e00290 pubmed publisher
    ..To identify mechanisms that scale the spindle during Xenopus laevis embryogenesis, we established an in vitro system using cytoplasmic extracts prepared from embryos that ..
  50. Leung L, Urbancic V, Baudet M, Dwivedy A, Bayley T, Lee A, et al. Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation. Nat Neurosci. 2013;16:166-73 pubmed publisher
    ..in the mid-dorsal optic tract neuroepithelium and in the axons of developing retinal ganglion cells (RGC) in Xenopus laevis. Here we report that targeted disruption of NFPC function in RGC axons or the optic tract neuroepithelium ..
  51. Kim S, Shindo A, Park T, Oh E, Ghosh S, Gray R, et al. Planar cell polarity acts through septins to control collective cell movement and ciliogenesis. Science. 2010;329:1337-40 pubmed publisher
    ..These findings shed light on the mechanisms by which fundamental cellular machinery, such as the cytoskeleton, is regulated during embryonic development and human disease. ..
  52. Wilmes J, Haddad Tóvolli R, Alesutan I, Munoz C, Sopjani M, Pelzl L, et al. Regulation of KCNQ1/KCNE1 by β-catenin. Mol Membr Biol. 2012;29:87-94 pubmed publisher
    ..In conclusion, β-catenin enhances I(Ks) by increasing the KCNE1/KCNQ1 protein abundance in the cell membrane, an effect requiring vesicle insertion into the cell membrane. ..
  53. Goodman B, Channels W, Qiu M, Iglesias P, Yang G, Zheng Y. Lamin B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly. J Biol Chem. 2010;285:35238-44 pubmed publisher
    ..Without lamin B, increased microtubule assembly caused by the released SAFs would lead to excessive microtubule sliding that results in formation of elongated and multipolar spindles. ..
  54. Park B, Hong C, Weaver J, Rosocha E, Saint Jeannet J. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus. Dev Biol. 2012;362:65-75 pubmed publisher
    ..We propose that Runx1 function is critically required for the generation of RB sensory neurons, an activity reminiscent of that of Runx1 in the development of the mammalian dorsal root ganglion nociceptive sensory neurons. ..
  55. Hindley C, Ali F, McDowell G, Cheng K, Jones A, Guillemot F, et al. Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation. Development. 2012;139:1718-23 pubmed publisher
    ..These observations explain how Ngn2 post-translational modification in response to changes in the cell cycle kinase environment results in enhanced neuronal differentiation upon cell cycle lengthening. ..
  56. Carlstrom L, Hines J, Henle S, Henley J. Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth. BMC Biol. 2011;9:82 pubmed publisher
    ..Techniques for manipulating integrin internalization and activation state may be important for overcoming local inhibitory factors after traumatic injury or neurodegenerative disease to enhance regenerative nerve growth. ..
  57. Li P, Chen C, Lee C, Madhavan R, Peng H. Axonal filopodial asymmetry induced by synaptic target. Mol Biol Cell. 2011;22:2480-90 pubmed publisher
    ..These results suggest that bFGF activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment. ..
  58. Drews C, Senkel S, Ryffel G. The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps. BMC Dev Biol. 2011;11:5 pubmed publisher
    ..Significantly, HNF1B activates the lhx1 promoter directly, thus extending the known activin A regulation of the lhx1 gene via an activin A responsive element. ..
  59. Shen W, McKeown C, Demas J, Cline H. Inhibition to excitation ratio regulates visual system responses and behavior in vivo. J Neurophysiol. 2011;106:2285-302 pubmed publisher
    ....
  60. Myers J, Gomez T. Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones. J Neurosci. 2011;31:13585-95 pubmed publisher
    ..We also show that growth cone turning depends on both signaling cascades tested here. Finally, we provide the first evidence that growth cone point contacts are asymmetrically regulated during turning to an attractive guidance cue. ..
  61. Armache K, Garlick J, Canzio D, Narlikar G, Kingston R. Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science. 2011;334:977-82 pubmed publisher
    ..The structure explains how covalent modifications on H4K16 and H3K79 regulate formation of a silencing complex that contains the nucleosome as a central component. ..
  62. Hong J, Park J, Cho K, Gu D, Ji H, Artandi S, et al. Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. J Cell Sci. 2010;123:4351-65 pubmed publisher
    ....
  63. Carmona Fontaine C, Theveneau E, Tzekou A, Tada M, Woods M, Page K, et al. Complement fragment C3a controls mutual cell attraction during collective cell migration. Dev Cell. 2011;21:1026-37 pubmed publisher
    ..We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents. ..
  64. Ciau Uitz A, Pinheiro P, Kirmizitas A, Zuo J, Patient R. VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus. Development. 2013;140:2632-42 pubmed publisher
    ..Thus, detailed temporal, epistatic measurements of key TFs and VEGFA plus its receptor have enabled us to build a Xenopus adult haemangioblast GRN. ..
  65. Gambus A, Khoudoli G, Jones R, Blow J. MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem. 2011;286:11855-64 pubmed publisher
    ..The CMG proteins also associate less strongly with other replication proteins, consistent with the idea that a single CMG complex forms the core of the replisome. ..
  66. Bugner V, Tecza A, Gessert S, Kuhl M. Peter Pan functions independently of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis. Development. 2011;138:2369-78 pubmed publisher
    ..that PPan is expressed maternally as well as in the eye and cranial neural crest cells (NCCs) during early Xenopus laevis development...
  67. You Z, Shi L, Zhu Q, Wu P, Zhang Y, Basilio A, et al. CtIP links DNA double-strand break sensing to resection. Mol Cell. 2009;36:954-69 pubmed publisher
    ..Thus, CtIP facilitates the transition from DSB sensing to processing: it does so by binding to the DNA at DSBs after DSB sensing and ATM activation and then promoting DNA resection, leading to checkpoint activation and HR. ..
  68. Callery E, Thomsen G, Smith J. A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus. Dev Biol. 2010;340:75-87 pubmed publisher
    ..Our data thus identify an important new function for this key developmental regulator. ..
  69. Chung M, Peyrot S, Leboeuf S, Park T, McGary K, Marcotte E, et al. RFX2 is broadly required for ciliogenesis during vertebrate development. Dev Biol. 2012;363:155-65 pubmed publisher
    ..Furthermore, we show that Rfx2 is essential for expression of several ciliogenic genes, including TTC25, which we show here is required for ciliogenesis, HH signaling, and left-right patterning. ..
  70. Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell. 2010;140:349-59 pubmed publisher
    ..Taken together, these results indicate that Treslin and TopBP1 collaborate in the Cdk2-mediated loading of Cdc45 onto replication origins. Thus, Treslin regulates a pivotal step in the initiation of DNA replication in vertebrates. ..
  71. Al Bassam J, Chang F. Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP. Trends Cell Biol. 2011;21:604-14 pubmed publisher
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